Chinese Journal of Chemistry最新文献

{"title":"Built-in Electric Field Enables Relay Catalysis in Ni4Mo/MoO2 Mott-Schottky Heterojunction for Selective Methanol-to-Formate Electrooxidation","authors":"Shuai He,&nbsp;Man Zhao,&nbsp;Ze Wang,&nbsp;Shili Fang,&nbsp;Yuhong Chang,&nbsp;Junming Zhang,&nbsp;Li Zhang,&nbsp;Haishun Wu,&nbsp;He Xiao,&nbsp;JianFeng Jia","doi":"10.1002/cjoc.70693","DOIUrl":"https://doi.org/10.1002/cjoc.70693","url":null,"abstract":"<div>\u0000 \u0000 <p>The selective electrooxidation of methanol to formate is a kinetically complex process involving multiple intermediates (<i>e.g</i>., *CH₃O, *CHO, *OH), whose adsorption energies are difficult to regulate simultaneously. Here, we report a conceptually new electric-field-directed relay catalysis strategy based on a Ni₄Mo/MoO₂ Mott-Schottky heterojunction. Using a combination of UPS, XPS, and XAFS, we demonstrate that the built-in electric field (BIEF) drives directional electron transfer from metallic Ni₄Mo to semiconducting MoO₂, creating spatially separated electron-deficient Ni sites and electron-rich MoO₂ interfaces. Operando FTIR and Raman spectroscopy directly visualize the dynamic evolution of intermediates, revealing a relay mechanism: Ni sites promote *CH₃O adsorption and C–H/O–H bond cleavage, while MoO₂ enhances *OH supply to accelerate *CHO oxidation. DFT calculations confirm that this BIEF-mediated spatial decoupling lowers the energy barrier of the potential-determining step (*CHO → *HCOOH) from 1.96 eV (Ni₄Mo) to only 0.76 eV. Consequently, the obtained catalyst achieves a peak current density of 345.2 mA·cm^–2 with &gt;97% Faradaic efficiency for formate. This work establishes a new paradigm for designing heterojunction electrocatalysts that leverage interfacial electric fields to orchestrate multi-step reaction pathways with high selectivity.</p>\u0000 <p></p>\u0000 </div>","PeriodicalId":151,"journal":{"name":"Chinese Journal of Chemistry","volume":"44 18","pages":"3043-3054"},"PeriodicalIF":5.7,"publicationDate":"2026-08-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148753777","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Chiral Amide Chain End Directed Asymmetric Crystallization-Driven Self-Assembly of Oligo(p-phenylenevinylene) Oligomers: Influence of Structure of Amide Chain Ends†","authors":"Huazhang Wang,&nbsp;Jialing Dong,&nbsp;Hongqing Zhang,&nbsp;Longgang Xia,&nbsp;Xinghao Du,&nbsp;Chun Feng","doi":"10.1002/cjoc.70701","DOIUrl":"https://doi.org/10.1002/cjoc.70701","url":null,"abstract":"<div>\u0000 \u0000 <p>Asymmetric crystallization-driven self-assembly (CDSA) of π-conjugated units has emerged as an efficient strategy to generate chiroptical nanostructures. Although the chiral chain end directed asymmetric CDSA is considered as an efficient and economical route, the reports on this subject are rare and our understanding on how the structure of chiral chain ends affects the asymmetric CDSA behavior remains limited. Herein, a series of oligo(<i>p-</i>phenylenevinylene) pentamer (OPV₅) derivatives with comparable compositions but varying chain end structures, including OPV₅-(<i>R</i>,<i>R</i>)-NH₂ and OPV₅-(<i>S</i>,<i>S</i>)-NH₂ with a chiral amide chain end, OPV₅-(1<i>R</i>,2<i>S</i>)-NH₂ with a mesomeric amide chain end, and OPV₅-L-NH₂ with an achiral linear amide chain end, respectively, were synthesized. OPV₅-(<i>R</i>,<i>R</i>)-NH₂ and OPV₅-(<i>S</i>,<i>S</i>)-NH₂ gave helical ribbon-like micelles with a preferred handedness, whereas OPV₅-(1<i>R</i>,2<i>S</i>)-NH₂ and OPV₅-L-NH₂ afforded equal amounts of racemic isomers of helical ribbon-like micelles. By taking advantage of electrostatic interactions, functional units of tetrakis(4-sulfophenyl)porphyrin can co-CDSA with OPV₅-(<i>R</i>,<i>R</i>)-NH₂ or OPV₅-(<i>S</i>,<i>S</i>)-NH₂ to give helical ribbon-like micelles with enhanced Cotton effect, which was dependent on both the content and structure of SO₃H-containing species. This work not only provides some deeper insights into chiral chain end directed asymmetric CDSA behaviors, but also offers a new strategy to generate π-conjugated chiroptical nanostructures.</p>\u0000 <p></p>\u0000 </div>","PeriodicalId":151,"journal":{"name":"Chinese Journal of Chemistry","volume":"44 18","pages":"2978-2988"},"PeriodicalIF":5.7,"publicationDate":"2026-08-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148753778","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Radiocatalytic Conversion Platform Enables Upcycling of CHF3 Waste to Fluorochemical","authors":"Yugang Zhang,&nbsp;Bo-Shuai Mu,&nbsp;Minghao Tan,&nbsp;Rui Wang,&nbsp;Zhibo Liu","doi":"10.1002/cjoc.70667","DOIUrl":"https://doi.org/10.1002/cjoc.70667","url":null,"abstract":"<div>\u0000 \u0000 <p>Fluoroform (CHF₃), a potent greenhouse gas produced by fluorochemicals production, has garnered attention as a valuable feedstock for synthesizing fluorochemicals, benefiting from its high-value trifluoromethyl group. A common approach to activating CHF₃ is C–H heterolysis using a base to deprotonate CHF₃, followed by a combination with a Lewis acid (LA) to form (LA)-CF₃ adduct. However, restricted by the poor compatibility of the reaction mixture, only elaborately designed pairs of LAs and bases can meet the requirement of promoting the formation of a Lewis acid (LA)-CF₃ adduct. Herein, we report a C–H homolysis strategy that utilizes the ·OH generated by water radiolysis to activate CHF₃, forming ·CF₃. Notably, as a proof-of-concept, an ideal route to produce trifluoroacetic acid (CF₃COOH, TFA) using CHF₃ and CO₂ as the starting materials was conducted via the ·CF₃ radical pathway. A radiation-synthesized Cu/ZnO with bifunctional properties was used as a catalyst, enhancing reaction efficiency and product selectivity by improving water radiolysis efficiency and regulating radical selectivity. This study proposes a novel strategy for upcycling CHF₃ through water radiolysis-mediated C–H homolysis, supported by an alternative pathway that converts CHF₃ into valuable fluorinated compounds using CHF₃ and CO₂ as feedstocks.</p>\u0000 <p></p>\u0000 </div>","PeriodicalId":151,"journal":{"name":"Chinese Journal of Chemistry","volume":"44 18","pages":"3005-3011"},"PeriodicalIF":5.7,"publicationDate":"2026-08-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148753984","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nickel-Catalyzed Hydroamination of Olefins Utilizing Isoxazole as an NH3 Surrogate for the Synthesis of Aliphatic Primary Amines","authors":"Xiongwei Zhong,&nbsp;Changshu Wu,&nbsp;Yanping Huo,&nbsp;Xianwei Li,&nbsp;Qian Chen,&nbsp;Yang Gao","doi":"10.1002/cjoc.70700","DOIUrl":"https://doi.org/10.1002/cjoc.70700","url":null,"abstract":"<div>\u0000 \u0000 <p>Aliphatic primary amines widely occur in pharmaceuticals, natural products, and bioactive compounds and serve as indispensable building blocks in organic synthesis. Alkene hydroamination enables the straightforward synthesis of amines from inexpensive and readily available alkene feedstocks; however, the efficient and selective construction of aliphatic primary amines via this strategy remains a formidable challenge. Herein, we developed a nickel-catalyzed umpolung hydroamination of olefins using 5-methoxy-3-phenylisoxazole as a sustainable and recyclable NH₃ surrogate for the convenient synthesis of aliphatic primary amines. This earth-abundant metal-catalyzed protocol displays broad substrate scope and good functional group tolerance, accommodating aryl alkenes, cyclic alkenes, unactivated aliphatic alkenes and internal alkenes under mild reaction conditions. The enamine intermediates undergo mild hydrolysis to afford aliphatic primary amines, with the released phenylacetoacetate to be recyclable to regenerate the isoxazole reagent. Additionally, asymmetric catalytic hydroamination of alkenes has also been achieved to afford chiral amine derivatives with moderate to good enantioselectivities (up to 96% ee). Mechanistic studies support a NiH-catalyzed umpolung three-component hydroamination pathway.</p>\u0000 <p></p>\u0000 </div>","PeriodicalId":151,"journal":{"name":"Chinese Journal of Chemistry","volume":"44 18","pages":"3077-3082"},"PeriodicalIF":5.7,"publicationDate":"2026-08-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148754207","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cobalt-Catalyzed anti-Markovnikov Hydroamidation of Allenes","authors":"Yumeng Liu,&nbsp;Weisheng Li,&nbsp;Jing Wang,&nbsp;Bingxue Liu","doi":"10.1002/cjoc.70699","DOIUrl":"https://doi.org/10.1002/cjoc.70699","url":null,"abstract":"<div>\u0000 \u0000 <p>Allene hydroamidation represents a highly valuable strategy for the synthesis of allylic amides, which are important synthetic intermediates and widely found in pharmaceuticals and bioactive compounds. Despite the considerable progress achieved in allene hydroamination, the corresponding hydroamidation remains largely underdeveloped. Herein, we report a cobalt-catalyzed <i>anti</i>-Markovnikov hydroamidation of allenes using dioxazolones as readily available amidating reagents. This method proceeds under mild reaction conditions and delivers a broad range of structurally diverse <i>E</i>-allylic amides with excellent regioselectivity and stereoselectivity, generally affording products with &gt;20 : 1 rr and &gt;20 : 1 <i>E</i>/<i>Z</i>. The reaction exhibits broad substrate scope and excellent functional-group tolerance, accommodating a variety of electronically diverse allenes and dioxazolones. Beyond its generality, the practical utility of this method is further demonstrated by the late-stage functionalization of complex bioactive molecules, highlighting its potential for application in the rapid diversification of medicinally relevant scaffolds. Notably, the concise synthesis of the NMDA receptor antagonist and its analogues further underscore the synthetic value of this protocol and its promise for the preparation of structurally complex allylic amides-containing compounds. Preliminary mechanistic studies support a catalytic pathway involving allyl-cobalt and cobalt-nitrenoid intermediates, offering mechanistic insights into the transformation.</p>\u0000 <p></p>\u0000 </div>","PeriodicalId":151,"journal":{"name":"Chinese Journal of Chemistry","volume":"44 18","pages":"3063-3069"},"PeriodicalIF":5.7,"publicationDate":"2026-08-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148754205","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Recent Zeolite Modifications in Bifunctional Catalysts for Carbon Dioxide Hydrogenation to Aromatics: A Minireview†","authors":"Weilin Wang,&nbsp;Qinghua Li,&nbsp;Tsz-Woon Benedict Lo,&nbsp;Ka-Fu Yung,&nbsp;Cong Lin","doi":"10.1002/cjoc.70649","DOIUrl":"https://doi.org/10.1002/cjoc.70649","url":null,"abstract":"<div>\u0000 \u0000 <section>\u0000 \u0000 <h3> Comprehensive Summary</h3>\u0000 \u0000 <p>Catalytic hydrogenation of carbon dioxide (CO₂) into aromatic hydrocarbons has emerged as a promising route for the high-value CO₂ utilization and sustainable aromatics production to alleviate fossil resource dependence under the carbon-neutrality goals. By integrating CO₂ activation/hydrogenation with the downstream C–C coupling and aromatization, bifunctional catalytic systems, typically comprising metal or metal oxide components coupled with acidic zeolites, enable the direct synthesis of valuable aromatics (<i>e.g.</i>, benzene, toluene, and xylene) from CO₂. Recently, significant progress has been made in the rational design of such catalysts, particularly through the precise tailoring of the zeolite component for regulating the reaction pathways, product selectivity, and catalyst stability. This minireview summarizes recent advances in CO₂ hydrogenation to aromatics achieved by bifunctional catalysts, with a specific focus on the decisive role of the zeolite properties in governing the aromatization behaviors. Various zeolite modification strategies, such as acidity regulation, metal and non-metal functionalization, pore-structure engineering, and morphology control, are systematically discussed in relation to their effects on the intermediate transformation and aromatic selectivity. Finally, perspectives on future research are presented, emphasizing the importance of advanced characterization techniques and theoretical modeling for the rational design of more efficient, selective, and stable CO₂-to-aromatics catalysts and technologies.</p>\u0000 \u0000 <p></p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Key Scientists</h3>\u0000 \u0000 <p></p>\u0000 </section>\u0000 </div>","PeriodicalId":151,"journal":{"name":"Chinese Journal of Chemistry","volume":"44 17","pages":"2933-2949"},"PeriodicalIF":5.7,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/cjoc.70649","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148652418","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Programming Aggregation-Induced Emission Luminogens into Vinyl Polymer Backbones via Macrocyclic Radical Ring-Opening Copolymerization","authors":"Ping Yi,&nbsp;Zhuofeng Ke,&nbsp;Derong Cao,&nbsp;Hanchu Huang","doi":"10.1002/cjoc.70681","DOIUrl":"https://doi.org/10.1002/cjoc.70681","url":null,"abstract":"<div>\u0000 \u0000 <p>The incorporation of fluorophores into vinyl polymer backbones is highly desirable for developing advanced functional materials, yet remains a significant challenge due to the inert nature of the all-carbon backbone. In this work, we present a versatile strategy to overcome this architectural limitation by directly integrating fluorophores into the vinyl polymer backbones. This is accomplished through the design and efficient synthesis of a novel macrocyclic monomer that incorporates tetraphenylethene (TPE), a well-known aggregation-induced emission (AIE) luminogen. Using photoinduced electron transfer–reversible addition–fragmentation chain transfer (PET-RAFT) polymerization, we successfully demonstrated, for the first time, the effective incorporation of AIE units into vinyl polymer backbones. The polymerization proceeds in a controlled manner, as evidenced by first-order kinetics and a linear increase in molecular weight with monomer conversion. This strategy is easily adaptable to a wide range of commercial vinyl monomers. The resulting polymers exhibit pronounced AIE behavior and can degrade under basic conditions. This methodology not only expands the synthetic toolbox for main-chain functionalization but also provides a versatile platform for designing next-generation vinyl polymers with inherent luminescent properties.</p>\u0000 <p></p>\u0000 </div>","PeriodicalId":151,"journal":{"name":"Chinese Journal of Chemistry","volume":"44 17","pages":"2897-2904"},"PeriodicalIF":5.7,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148652508","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Electrohydrogenative Coupling of Thioamides with Olefins by Cobalt Catalysis","authors":"Wei Jiang,&nbsp;Cong Xie,&nbsp;Jie Liu","doi":"10.1002/cjoc.70666","DOIUrl":"https://doi.org/10.1002/cjoc.70666","url":null,"abstract":"<div>\u0000 \u0000 <p>Catalytic reduction of unsaturated substrates provides a powerful tool for bulk and fine chemical synthesis. However, very few examples have been reported on the reductive transformation of thioamides, presumably because of the poisoning of catalysts by sulfur-containing molecules. Herein, we describe an efficient and sustainable hydrogenative coupling of thioamides with olefins under electrocatalytic conditions. The key to success for this reductive process is the application of an earth-abundant cobalt complex as the cost-effective and robust molecular electrocatalyst. As only protons (H⁺) and electrons (e^–) as the hydrogen source and redox equivalent, this polarity-reversed electrochemical protocol is showcased by highly selective and straightforward synthesis of a wide range of α-branched amines, as well as deuterium isotope labeling applications. Over 60 α-branched amines, including 12 deuterated analogues, have been successfully synthesized. Notably, a variety of functional groups, including aryl halides, esters, and nitriles, are well tolerated under the mild electrochemical conditions. Furthermore, late-stage modification of complex molecules has also been achieved. Mechanistic studies indicate that the <i>in-situ</i> generated imines and α-amino radicals by cobalt-electrocatalytic desulfurization of thioamides are identified as the key intermediates in this transformation. This work provides an alternative and versatile method for the synthesis of structurally diverse α-branched amines, with advantages including sustainability, high selectivity, and compatibility with isotope labeling and complex molecular functionalization.</p>\u0000 <p></p>\u0000 </div>","PeriodicalId":151,"journal":{"name":"Chinese Journal of Chemistry","volume":"44 17","pages":"2847-2854"},"PeriodicalIF":5.7,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148652507","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Controllable Chemodivergent Synthesis of α-Trifluoromethyl Boronates and gem-Difluoroalkenyl Boronates via Photoredox 1,2-Boron Migratory Carbonylation","authors":"Xiao-Fan Cui,&nbsp;Le-Cheng Wang,&nbsp;Xiao-Feng Wu","doi":"10.1002/cjoc.70684","DOIUrl":"https://doi.org/10.1002/cjoc.70684","url":null,"abstract":"<p>Fluorinated organoborons are highly valuable building blocks in drug discovery and materials science. However, the direct and step-economic synthesis of these complex structures remains a major challenge. Herein, we report a visible-light-driven, transition-metal-free chemodivergent borocarbonylation of <i>α</i>-trifluoromethyl styrenes. This multicomponent platform precisely controls the ultimate fate of the transient <i>α</i>-CF₃ benzylic radical. Under catalyst-free conditions, an electron donor-acceptor (EDA) complex with Hantzsch ester drives the radical cascade and a subsequent hydrogen atom transfer (HAT) to yield <i>α</i>-trifluoromethyl boronates. Alternatively, an Eosin Y/PMP photoredox system promotes a single-electron transfer (SET) and subsequent <i>β</i>-fluoride elimination to afford <i>gem</i>-difluoroalkenyl boronates. Overall, this strategy successfully manages the kinetic challenges of multi-step radical trapping, providing a practical and programmable platform to construct densely functionalized fluorinated organoborons.</p><p></p>","PeriodicalId":151,"journal":{"name":"Chinese Journal of Chemistry","volume":"44 17","pages":"2918-2926"},"PeriodicalIF":5.7,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/cjoc.70684","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148652512","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Photo-mediated One-Pot Glycosylation-Deprotection-Glycosylation Strategy for Synthesis of Histo-blood Group Antigens","authors":"Lvfeng Zhang,&nbsp;Huagen Chen,&nbsp;Youling Liang,&nbsp;Mengying Ru,&nbsp;Rurong Yu,&nbsp;Jiahao Fan,&nbsp;Xianchao Zhu,&nbsp;Liming Zhao,&nbsp;You Yang","doi":"10.1002/cjoc.70670","DOIUrl":"https://doi.org/10.1002/cjoc.70670","url":null,"abstract":"<div>\u0000 \u0000 <p>Glycans that are widely distributed in nature possess diverse biological activities. However, the inherent structural microheterogeneity of natural glycans impedes their functional evaluation. Chemical glycosylation serves as a powerful approach to access well-defined complex glycans for structure-activity relationship studies. In particular, one-pot multistep glycosylation enables the efficient assembly of complex glycans by eliminating intermediate purification and minimizing protecting-group manipulations. Nevertheless, a key limitation of this traditional approach is its inefficient late-stage coupling, which might result in the loss of valuable advanced donors. Here, we developed a photolabile ester-mediated one-pot glycosylation–deprotection–glycosylation strategy for the rapid assembly of both linear and branched oligosaccharides. Based on the photolabile <i>ortho</i>-nitro-benzyloxycarbonyl (<i>o</i>NBC) ester-mediated one-pot strategy from the reducing end to non-reducing end, efficient and stereoselective synthesis of oligomannoside, oligofucoside, and five types of HBGAs including A_tri, B_tri, H1, H3 and Le^b antigens was achieved. Various glycosyl leaving groups including ynenoates, trichloroacetimidates, <i>N</i>-phenyl trifluoroacetimidates, and thioglycosides were successfully employed in these photo-mediated one-pot reactions, with solvent and temperature identified as critical factors for stereoselective glycosidic bond formation. In contrast to the photolabile <i>o</i>-nitrobenzyl (<i>o</i>NB) group, the photolabile <i>o</i>NBC group could be readily introduced on the primary and secondary hydroxyls of sugar building blocks under mild basic conditions, which were fully compatible with common ester protecting groups. When installed at the C-2 position of glycosyl donors, the <i>o</i>NBC group typically favored the formation of β-glycosidic bonds. The binding results indicated that the H1 receptor exhibited superior binding to norovirus-like particles relative to the H3 receptor, thereby serving as a valuable tool for assessing norovirus vaccine-elicited antibodies. The photolabile ester-mediated one-pot strategy provides a versatile platform for the streamlined assembly of architecturally complex and branched glycans.</p>\u0000 <p></p>\u0000 </div>","PeriodicalId":151,"journal":{"name":"Chinese Journal of Chemistry","volume":"44 17","pages":"2887-2896"},"PeriodicalIF":5.7,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148652420","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}