双官能团Brønsted碱催化级联反应合成1,7-环茚唑衍生物

IF 5.5 1区化学 Q2 CHEMISTRY, MULTIDISCIPLINARY

Chinese Journal of Chemistry Pub Date : 2025-03-22 DOI:10.1002/cjoc.70010

Pengcheng Shao, Weiwu Ren

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引用次数: 0

摘要

采用双官能团Brønsted碱催化级联反应，建立了一种不对称合成1,7环茚唑的新方法。该工艺可形成多个手性中心，包括一个季碳中心，收率高，具有优异的非对映选择性和对映选择性。该反应具有广泛的官能团耐受性和温和的反应条件。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

查看原文本刊更多论文

Synthesis of 1,7-Annulated Indazole Derivatives via Bifunctional Brønsted Base Catalyzed Cascade Reaction

A novel method for the asymmetric synthesis of 1,7-annulated indazoles has been developed via bifunctional Brønsted base catalyzed cascade reaction. This process enabled the formation of multiple chiral centers including a quaternary carbon center in high yields with excellent diastereoselectivities and enantioselectivities. The reaction exhibited broad functional group tolerance and mild reaction conditions.

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来源期刊

Chinese Journal of Chemistry 化学-化学综合

CiteScore

8.80

自引率

14.80%

发文量

422

审稿时长

1.7 months

期刊介绍： The Chinese Journal of Chemistry is an international forum for peer-reviewed original research results in all fields of chemistry. Founded in 1983 under the name Acta Chimica Sinica English Edition and renamed in 1990 as Chinese Journal of Chemistry, the journal publishes a stimulating mixture of Accounts, Full Papers, Notes and Communications in English.