镍催化的不对称还原1,4-和1,5-二碳官能化†

IF 5.5 1区化学 Q2 CHEMISTRY, MULTIDISCIPLINARY

Chinese Journal of Chemistry Pub Date : 2025-03-08 DOI:10.1002/cjoc.202500074

Yutong Xiang, Chang Zhang, Chuan Wang

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引用次数: 0

摘要

本文首次提出了1,3-二烯的1,4-二碳不对称还原官能化和乙烯基环丙烷的1,5-二碳官能化，这是在手性镍/双咪唑啉配合物的催化下进行的，这些配合物使用烷基卤化物和芳基碘化物或烯基溴作为亲电偶联伙伴。在这些高对映选择性转化中，C(sp3)-和C（sp2）型碳基团分别被安装在末端和内部位置上，具有高e选择性的新形成的烯烃单元。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Nickel-Catalyzed Asymmetric Reductive 1,4- and 1,5-Dicarbofunctionalization†

Herein, we present the first examples of asymmetric reductive 1,4-dicarbofunctionalization of 1,3-dienes and 1,5-dicarbofunctionalization of vinylcyclopropanes, which proceed under the catalysis of a chiral nickel/bis-imidazoline complex using alkyl halides and aryl iodides or alkenyl bromides as the electrophilic coupling partners. In these highly enantioselective transformations operating in a radical relay mechanism, the C(sp³)- and C(sp²)-type carbo-moieties are respectively installed on the terminal and internal position with a newly formed olefinic unit in high E-selectivity.

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来源期刊

Chinese Journal of Chemistry 化学-化学综合

CiteScore

8.80

自引率

14.80%

发文量

422

审稿时长

1.7 months

期刊介绍： The Chinese Journal of Chemistry is an international forum for peer-reviewed original research results in all fields of chemistry. Founded in 1983 under the name Acta Chimica Sinica English Edition and renamed in 1990 as Chinese Journal of Chemistry, the journal publishes a stimulating mixture of Accounts, Full Papers, Notes and Communications in English.