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The rapid and efficient construction of C—C, C—N, and C—O bonds is a prominent research area in organic synthesis. A biomass derived Cu/Chitosan-800 catalyst is prepared for carbenoid insertion reactions to form C—X (X = C, N, O) bond. The substrate scope is well-demonstrated by C—H bond insertion of arenes, heteroarenes, and 1,3-diketones; N—H bond insertion of alkylamines and aromatic amines; and O—H bond insertion of carboxylic acids and diphenylphosphinic acids. Notably, the late-stage functionalization of drug molecules using this approach is also feasible. More details are discussed in the article by Tang et al. on pages 916—924.