Journal of Cardiovascular Development and Disease最新文献

{"title":"Higher Physical Activity Is Associated with Improved Ventricular-Arterial Coupling: Assessment Using the cfPWV/GLS Ratio in Primary Care-A Pilot Study.","authors":"Paula-Anca Sulea, Ioan Tilea, Florin Stoica, Liviu Cristescu, Diana-Andreea Moldovan, Radu Tatar, Raluca-Maria Tilinca, Razvan Gheorghita Mares, Andreea Varga","doi":"10.3390/jcdd12060208","DOIUrl":"10.3390/jcdd12060208","url":null,"abstract":"<p><strong>Background: </strong>Age-related vascular stiffening increases cardiovascular risk by altering ventricular-arterial coupling (VAC). Physical activity, a modifiable factor, may improve cardiovascular health. This pilot study evaluated the relationship between physical activity evaluation and VAC, measured by the carotid-femoral pulse wave velocity to global longitudinal strain (cfPWV/GLS) ratio, in a Romanian primary care cohort.</p><p><strong>Methods: </strong>The prospective cohort analysis was performed on 81 adults (49 females, mean age 50.27 ± 12.93 years). Physical activity was quantified through anamnesis using metabolic equivalents (METs) according with Compendium of Physical Activities, and patients were stratified into four groups: G1 (METs < 1.5, <i>n</i> = 39), G2 (METs = 1.5-2.9, <i>n</i> = 2), G3 (METs = 3-5.9, <i>n</i> = 23), and G4 (METs ≥ 6, <i>n</i> = 17). Demographic and echocardiographic data were recorded to explore associations between physical activity and VAC.</p><p><strong>Results: </strong>The cfPWV/GLS ratio differed significantly across groups (<i>p</i> = 0.012), with the lowest values present in the moderate-intensity group (G3). VAC ≥ 0.391 can predict sedentary lifestyles (AUC = 0.730; CI: 0.617-0.833, <i>p</i> > 0.001). Multivariate analysis revealed that age, arterial age, and hypertension independently predict VAC.</p><p><strong>Conclusions: </strong>Higher physical activity is inversely associated with VAC (cfPWV/GLS ratio) and can predict sedentary lifestyles. Encouraging moderate-to-vigorous exercise in primary care may improve cardiovascular function and aid prevention.</p>","PeriodicalId":15197,"journal":{"name":"Journal of Cardiovascular Development and Disease","volume":"12 6","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12193474/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144484435","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Doxorubicin-Induced Cardiotoxicity: A Comprehensive Update.","authors":"Vasvi Bhutani, Fahimeh Varzideh, Scott Wilson, Urna Kansakar, Stanislovas S Jankauskas, Gaetano Santulli","doi":"10.3390/jcdd12060207","DOIUrl":"10.3390/jcdd12060207","url":null,"abstract":"<p><p>Doxorubicin is an anthracycline chemotherapeutic that is widely used for treating various malignancies, including breast cancer, lymphomas, and sarcomas. Despite its efficacy, its clinical utility is limited by a well-documented risk of cardiotoxicity, which may manifest acutely or chronically. Doxorubicin works by intercalating DNA and inhibiting topoisomerase II, leading to DNA damage and cell death. However, this mechanism is not selective to cancer cells and can adversely affect cardiac myocytes. The introduction of doxorubicin into oncologic practice has revolutionized cancer treatment, but its cardiotoxic effects remain a significant concern. This systematic review aims to comprehensively examine the multifaceted impact of doxorubicin on cardiac structure and function through both preclinical and clinical lenses.</p>","PeriodicalId":15197,"journal":{"name":"Journal of Cardiovascular Development and Disease","volume":"12 6","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12193598/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144484430","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of Primary Diagnosis on the Outcome of Heart Transplantation in Children.","authors":"Csaba Vilmányi, Zsolt L Nagy, György S Reusz, László Ablonczy","doi":"10.3390/jcdd12060205","DOIUrl":"10.3390/jcdd12060205","url":null,"abstract":"<p><strong>Introduction: </strong>Pediatric heart transplantation (HTX) remains the only therapeutic option for end-stage heart failure not amenable to conventional surgical or catheter interventions. We reviewed our pediatric HTX outcomes according to primary diagnosis.</p><p><strong>Patients and methods: </strong>Sixty-two patients underwent HTX between 01/2007 and 12/2022. Patients were divided into congenital heart disease (CHD, n = 20) and cardiomyopathy (CMP, n = 42) groups. All potential variables relevant to patient recovery and long-term survival with endpoints of retransplantation or death were analyzed.</p><p><strong>Results: </strong>CHD patients underwent HTX after significantly more multiple major cardiac surgeries per patient (2.5 [0-5]) than CMP patients (0.5 [0-2], <i>p</i> < 0.01), without notable allosensitization. Post-HTX recovery was longer in CHD (mean mechanical ventilation 7 vs. 3 days, <i>p</i> = 0.001), likely due to longer surgical time (468 vs. 375 min, <i>p</i> = 0.037). There were no significant differences in the frequency of rejections between the two groups (4/20 vs. 9/42). Midterm survival was slightly better (85/70% <i>p</i> = NS) in CMP (median follow-up 44.5 [0-177] months).</p><p><strong>Conclusion: </strong>Our study confirmed good short- and long-term outcomes of pediatric HTX in both CMP and CHD. The longer postoperative recovery in CHD did not lead to higher mortality. No higher pretransplant hypersensitization was observed, possibly explaining the lack of difference in the number and severity of rejections.</p>","PeriodicalId":15197,"journal":{"name":"Journal of Cardiovascular Development and Disease","volume":"12 6","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-05-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12194210/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144484451","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Considerations on the Development of Therapeutics in Vascular Calcification.","authors":"Ana M Valentin Cabrera, Sophie K Ashbrook, Joshua D Hutcheson","doi":"10.3390/jcdd12060206","DOIUrl":"10.3390/jcdd12060206","url":null,"abstract":"<p><p>Cardiovascular disease is the leading cause of death worldwide. Vascular calcification, the deposition of calcium phosphate mineral in the arterial wall, is the most significant predictor of morbidity and mortality. Vascular calcification can present as either medial or intimal calcification. Medial calcification is most prevalent among patients with chronic kidney disease. Intimal calcification is associated with atherosclerosis and chronic inflammation. In both cases, vascular smooth muscle cells undergo osteogenic differentiation, leading to mineral deposition and associated wall stiffening; however, the effects on cardiovascular function and morbidity vary depending on mineral morphology and location. This review investigates vascular calcification, the mechanisms leading to calcium deposition, and what to consider when developing therapeutics for vascular calcification.</p>","PeriodicalId":15197,"journal":{"name":"Journal of Cardiovascular Development and Disease","volume":"12 6","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-05-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12193968/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144484428","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Role of Serum Uric Acid and Serum Creatinine Ratio as Possible Markers of Autonomic Dysfunction and Left Ventricular Mass Index in Atherosclerotic Renal Artery Stenosis.","authors":"Antonietta Gigante, Rosa Cascone, Chiara Pellicano, Francesco Iannazzo, Francesca Romana Gadaleta, Edoardo Rosato, Rosario Cianci","doi":"10.3390/jcdd12060202","DOIUrl":"10.3390/jcdd12060202","url":null,"abstract":"<p><strong>Background: </strong>Serum uric acid and serum creatinine ratio (SUA/sCr) is strongly linked to increased cardiovascular risk. Atherosclerotic renal artery stenosis (ARAS) is a secondary cause of hypertension and is associated with ischemic nephropathy, congestive heart failure, accelerated cardiovascular disease, and autonomic dysfunction. The aim of this study was to investigate whether SUA levels and SUA/sCr could represent markers of autonomic dysfunction and increased left ventricular mass index (LVMI) in patients with ARAS.</p><p><strong>Methods: </strong>Patients diagnosed with ARAS were enrolled in the study. All patients underwent clinical evaluation, biochemical analysis, 24 h electrocardiogram (ECG), and Renal Doppler Ultrasound with renal resistive index parameters. Heart rate variability for global autonomic dysfunction was assessed through the analysis of a 24 h ECG to detect the standard deviation of normal-to-normal RR intervals (SDNN). Echocardiographic measurement of LVMI was performed.</p><p><strong>Results: </strong>A total of 27 patients (F = 16 (59%), median age 67 years (IQR 60-77)) diagnosed with ARAS were enrolled in the study. We found a statistically significant negative linear correlation between SUA/sCr and SDNN (r = -0.519, <i>p</i> < 0.01). We found a statistically significant positive linear correlation between SUA/sCr and LVMI (r = 0.413, <i>p</i> < 0.05). Median SDNN was significantly lower in patients with SUA ≥ 5.6 mg/dL than in patients with SUA < 5.6 mg/dL (94.2 (IQR 86.8-108.1) vs. 112.8 (IQR 108.9-114.7), <i>p</i> < 0.01). Median LVMI was significantly higher in patients with SUA ≥ 5.6 mg/dL compared to patients with SUA < 5.6 mg/dL (133 g/m² (IQR 120-149) vs. 111 g/m² (IQR 99-129), <i>p</i> < 0.05).</p><p><strong>Conclusion: </strong>In patients with ARAS, SUA/sCr is associated with autonomic dysfunction and LVMI in ARAS patients. The ratio and related cut-off value of SUA/sCr could represent a useful biomarker to evaluate cardiovascular risk in ARAS patients.</p>","PeriodicalId":15197,"journal":{"name":"Journal of Cardiovascular Development and Disease","volume":"12 6","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12194173/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144484490","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessment of Age and Sex Difference in Cardiopulmonary Function of Children and Adolescents with Ventricular Septal Defect.","authors":"Chao-Ruei Lin, Ya-Fen Liu, I-Ching Huang, Yi-Jen Chen, Chia-Hsin Chen, Ko-Long Lin","doi":"10.3390/jcdd12060204","DOIUrl":"10.3390/jcdd12060204","url":null,"abstract":"<p><p>In the past, an isolated ventricular septal defect (VSD) was categorized as a simple lesion with assumed negligible long-term risks when treated correctly in childhood; however, evidence has suggested that patients with isolated congenital VSDs carry a substantial burden of cardiovascular morbidity throughout life. This study aimed to investigate the cardiopulmonary function (CPF) in isolated VSD patients of a young age and the relationship of CPF with age, sex and body mass index (BMI). This retrospective cohort study was conducted at a tertiary medical center in southern Taiwan. We recruited children and adolescents (aged 5 to 18 years) with isolated VSDs who underwent the symptom-limited treadmill exercise test. Data from 289 children and adolescents (157 males, 132 females) were included in the analysis. The participants were stratified into three groups according to age. The male patients had a significantly higher oxygen uptake at the anaerobic threshold (AT VO₂) and a higher peak oxygen uptake (peak VO₂) (all <i>p</i> < 0.05). Normalized AT VO₂ (mL/kg/min) and normalized peak VO₂ (mL/kg/min) were significantly negatively associated with BMI. In conclusion, male patients with isolated VSDs had similar or better CPF compared with female patients. BMI had a negative association with CPF in young VSD patients.</p>","PeriodicalId":15197,"journal":{"name":"Journal of Cardiovascular Development and Disease","volume":"12 6","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12194454/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144484392","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Rare Case of Hypercalcemia from Mediastinal Ectopic Hyperparathyroidism.","authors":"Nasrin Dhapa, Lamar Alocozy, Rumana Khan","doi":"10.3390/jcdd12060201","DOIUrl":"10.3390/jcdd12060201","url":null,"abstract":"<p><p>Hypercalcemia is frequently attributed to primary hyperparathyroidism, commonly a result of parathyroid adenomas. Ectopic hyperparathyroidism is characterized by hyperfunctioning parathyroid tissue located outside of expected anatomical locations of endocrine tissue. In this report, we present a rare case of hypercalcemia secondary to a mediastinal ectopic parathyroid adenoma, located between the left atrium and pulmonary artery. Given the unique location of the ectopic gland, diagnosis was delayed with additional complications that followed due to difficulty accessing the gland surgically. Despite this, urgent surgical removal of the ectopic gland allowed for remarkable improvement in presenting symptoms. This clinical case highlights diagnostic and therapeutic challenges that present a unique situation worthy of clinical discussion.</p>","PeriodicalId":15197,"journal":{"name":"Journal of Cardiovascular Development and Disease","volume":"12 6","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12193956/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144484389","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Sphincter-like Function of Pulmonary Vein Ostia in Normal and Atrial Fibrillation Subjects.","authors":"Stefano Bonapace, Matteo Falanga, Carmelo Cicciò, Cristiana Corsi, Giulio Molon","doi":"10.3390/jcdd12060203","DOIUrl":"10.3390/jcdd12060203","url":null,"abstract":"<p><strong>Background: </strong>Early anatomical study suggested that the pulmonary vein (PVs) junction may have putative sphincter-like activity. The aim of this study was to evaluate this activity in normal and paroxysmal/persistent atrial fibrillation subjects.</p><p><strong>Methods: </strong>The Cardiac Computed Tomography (CCT) scans of 45 subjects [15 normal controls, 15 patients with paroxysmal atrial fibrillation (PAR-AF), and 15 with persistent AF (PER-AF)] were retrospectively analyzed. All subjects were in sinus rhythm during the CCT scan. A 3D anatomical model was developed, enabling us to identify the PV ostia and to measure their area dynamic changes during the cardiac cycle.</p><p><strong>Results: </strong>The area changes in the superior PVs within the three groups were significantly higher compared to the inferior (control <i>p</i> = 0.007, PAR-AF <i>p</i> = 0.0003, PER-AF <i>p</i> = 0.04). Moreover, these variations were significantly reduced in PAR-AF and PER-AF compared to the control in all PVs (LSPV (<i>p</i> < 0.001), RSPV (<i>p</i> < 0.001), RIPV (<i>p</i> = 0.037), and LIPV (<i>p</i> < 0.001)).</p><p><strong>Conclusions: </strong>This sphincter-like activity, most prominent in superior PVs, is progressively impaired in patients with paroxysmal and persistent AF.</p>","PeriodicalId":15197,"journal":{"name":"Journal of Cardiovascular Development and Disease","volume":"12 6","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12194796/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144484390","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Stroke: Risk Factors, Mechanisms, Outcomes and Ethnicity.","authors":"Narayanaswamy Venketasubramanian","doi":"10.3390/jcdd12060199","DOIUrl":"10.3390/jcdd12060199","url":null,"abstract":"<p><p>Stroke remains a leading cause of death and disability globally [...].</p>","PeriodicalId":15197,"journal":{"name":"Journal of Cardiovascular Development and Disease","volume":"12 6","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12193595/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144484485","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cardiac Magnetic Resonance in Heart Failure: Diagnostic and Prognostic Assessments.","authors":"Sara Pezzini, Francesca Daus, Giorgia Galli, Andrea Farina, Gabriele Fragasso, Roberto Spoladore","doi":"10.3390/jcdd12060200","DOIUrl":"10.3390/jcdd12060200","url":null,"abstract":"<p><p>With its high spatial resolution and tissue contrast, cardiac magnetic resonance (CMR) is an extremely flexible imaging technique that enables a thorough morphological and functional evaluation of the heart and vascular system. From diagnosis to treatment planning and risk assessment, CMR is being utilized more and more in the evaluation of patients with heart failure (HF). CMR offers a variety of techniques for characterizing myocardial tissue, aiding in identifying the cause of HF, as well as whole-heart cine imaging for precise measurement of biventricular dimensions and function. The aim of this review is to the describe the role of CMR in chronic heart failure, in particular for diagnostic workups, differential diagnosis, and information on how CMR influences treatment planning choices.</p>","PeriodicalId":15197,"journal":{"name":"Journal of Cardiovascular Development and Disease","volume":"12 6","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12193542/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144484424","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}