Journal of Cardiovascular Development and Disease最新文献

{"title":"Virtual Stenting Based on Fractional Flow Reserve Derived from Computed Tomography in Predicting Post-Percutaneous Coronary Intervention Functional Outcomes: A Retrospective Cohort Study.","authors":"Han Zhao, Yanlong Ren, Jiang Li, Mingduo Zhang, Lijun Zhang, Rongliang Chen, Jia Liu, Zhengzheng Yan, Xiantao Song","doi":"10.3390/jcdd12090373","DOIUrl":"10.3390/jcdd12090373","url":null,"abstract":"<p><p>With the advancement of fractional flow reserve (FFR) derived from computed tomography (FFR_CT), virtual stenting technology has gradually developed. This study investigated the performance of virtual stenting based on FFR_CT in predicting post-percutaneous coronary intervention (PCI) FFR. Data from 75 patients (78 blood vessels) was collected retrospectively. We randomly allocated the participants to discovery (<i>n</i> = 26) and validation (<i>n</i> = 52) cohorts. The FFR_CT was calculated using pre-PCI coronary computed tomography angiography images. Virtual stent implantation was simulated using blinded and non-blinded virtual stenting methods to obtain post-virtual stenting FFR_CT. The median FFR_CT before PCI and invasive FFR were 0.70 (0.60-0.77) and 0.69 (0.63-0.76), respectively. The median FFR_CT were 0.91 (0.86-0.95) and 0.91 (0.87-0.94) in the blinded and non-blinded groups, respectively; the invasive post-PCI FFR was 0.90 (0.88-0.93). The difference between the FFR_CT after using the blinded/non-blinded method and the invasive post-PCI FFR were 0.010 (95% limits of agreement: -0.064 to 0.084) and 0.009 (-0.050 to 0.068) in the discovery cohort and -0.005 (-0.075 to 0.064) and -0.0002 (-0.064 to 0.064) in the validation cohort, respectively. Virtual stenting technology based on FFR_CT can effectively predict functional outcomes after PCI and could be a reliable tool for PCI procedural planning.</p>","PeriodicalId":15197,"journal":{"name":"Journal of Cardiovascular Development and Disease","volume":"12 9","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-09-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12470931/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145149100","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impaired Left Atrial Strain as an Early Marker of Cardiac Involvement in Type 2 Diabetes Mellitus: A Cross-Sectional Study.","authors":"Laura-Cătălina Benchea, Larisa Anghel, Nicoleta Dubei, Răzvan-Liviu Zanfirescu, Gavril-Silviu Bîrgoan, Radu Andy Sascău, Cristian Stătescu","doi":"10.3390/jcdd12090369","DOIUrl":"10.3390/jcdd12090369","url":null,"abstract":"<p><p><b>Background:</b> Diabetic cardiomyopathy is a major contributor to cardiovascular morbidity, often progressing silently before overt heart failure. Left atrial (LA) strain, assessed via speckle-tracking echocardiography, could serve as an early indicator of subclinical myocardial dysfunction in patients with type 2 diabetes mellitus (T2DM). <b>Objectives:</b> The objectives of this study were to evaluate LA strain parameters in patients with T2DM versus non-diabetic controls and investigate their association with glycemic control and diabetes duration. <b>Methods:</b> This cross-sectional study, designed according to STROBE reporting guidelines, included 47 participants (25 with T2DM and 22 controls) undergoing comprehensive echocardiographic and biochemical evaluation. LA reservoir (LASr), conduit (LAScd), and booster-pump (LASbp) strain values were measured. Associations with glycosylated hemoglobin (HbA1c) and diabetes duration were assessed via multivariate analysis. ROC curves were used to evaluate predictive performance. <b>Results:</b> Diabetic patients had significantly lower LASr (20.4 ± 7.25% vs. 26.7 ± 8.0%, <i>p</i> = 0.007), LAScd (-10.9 ± 5.4% vs. -15.6 ± 6.5%, <i>p</i> = 0.010), and LASbp (-9.9 ± 4.2% vs. -12.9 ± 5.0%, <i>p</i> = 0.034). LASr and LAScd remained independent predictors in multivariate models. ROC analysis showed good discrimination (AUC: LAScd = 0.78; LASr = 0.73). <b>Conclusions:</b> This study demonstrates that LASr and LAScd are independently associated with type 2 diabetes mellitus and can reliably identify subclinical atrial dysfunction before the onset of structural or symptomatic heart disease.</p>","PeriodicalId":15197,"journal":{"name":"Journal of Cardiovascular Development and Disease","volume":"12 9","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12470892/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145149157","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Extracellular Volume Fraction Analysis on Cardiac Computed Tomography Is Useful for Predicting the Prognosis of Hypertrophic Cardiomyopathy.","authors":"Shuhei Aoki, Hiroyuki Takaoka, Tomonori Kanaeda, Kazunari Asada, Joji Ota, Yoshitada Noguchi, Moe Matsumoto, Yusei Nishikawa, Katsuya Suzuki, Satomi Yashima, Makiko Kinoshita, Noriko Suzuki-Eguchi, Haruka Sasaki, Kohei Takahashi, Yoshihito Ozawa, Yosuke Inaba, Yoshio Kobayashi","doi":"10.3390/jcdd12090372","DOIUrl":"10.3390/jcdd12090372","url":null,"abstract":"<p><p>Extracellular volume fraction (ECV) analysis on computed tomography (CT) is now available. The purpose of this study was to assess the usefulness of CT-derived ECV analysis for predicting outcomes in patients with hypertrophic cardiomyopathy (HCM). One hundred and one HCM patients (67 males, 66 ± 11 years old) who received cardiac CT between January 2009 and December 2021 were included. We measured left ventricular (LV) ECV (LV-ECV) on CT and investigated the relationship between LV-ECV and the major adverse cardiac events (MACE) after CT. Fifteen patients (15%) experienced MACE. The patients with MACE had a significantly higher LV-ECV, left atrial diameter, LV end-systolic diameter, and lower LVEF than those without MACE. The proportion of dilated phase HCM was significantly higher in the patients with MACE than those without MACE. LV-ECV and LVEF were significant predictors of MACE based on the multivariate analysis by Cox proportional hazards model. The optimal threshold of LV-ECV to predict MACE was 37.6% based on the receiver operating characteristic analysis. The patients with LV-ECV ≥ 37.6% (30 patients) experienced significantly higher MACE than those with LV-ECV < 37.6% (<i>p</i> < 0.001). CT-derived ECV analysis suggested potential usefulness for predicting MACE in patients with HCM.</p>","PeriodicalId":15197,"journal":{"name":"Journal of Cardiovascular Development and Disease","volume":"12 9","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12471191/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145149173","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"ADAMTS5 Orchestrates Cell Lineage Specific Patterning and Extracellular Matrix Organization During Semilunar Valve Development.","authors":"Loren E Dupuis, Joshua J Mifflin, Amy L Marston, Jeremy P Laxner, Christine B Kern","doi":"10.3390/jcdd12090371","DOIUrl":"10.3390/jcdd12090371","url":null,"abstract":"<p><p>Aortic valve (AV) disease affects about 5% of the aging population, with AV replacement as the only treatment option. Histopathology indicates that accumulation of extracellular matrix (ECM) proteoglycans correlates with dysfunctional AVs. Proteoglycan content is controlled by ECM proteolytic cleavage, with the cleaved and intact forms of the proteoglycan Versican (VCAN) occupying different cell lineage-specific regions throughout AV development. To test the hypothesis that VCAN cleavage is required for lineage specific cell behaviors and ECM stratification, the cardiac neural crest (CNC) lineage was traced in mice with global inactivation of the proteoglycan protease <i>Adamts5</i>. By mid-gestation, <i>Adamts5^-/-</i> mice exhibited disorganized CNC patterning with excess VCAN and enlarged semilunar valve (SLV) morphology. Use of the <i>Adamts5</i> floxed mice indicated that <i>Adamts5</i> was required in the endothelial cells and their mesenchymal derivatives (EndoMT lineage) to prevent VCAN accumulation, initiate ECM stratification, and promote normal SLV morphology. These data suggest that the ECM remodeling event of VCAN cleavage may orchestrate cell lineage distinct behaviors and interactions to control proteoglycan levels throughout AV development and to prevent disease. Understanding mechanisms that regulate VCAN content may lead to the discovery of effective pharmacological targets for the treatment of AV disease.</p>","PeriodicalId":15197,"journal":{"name":"Journal of Cardiovascular Development and Disease","volume":"12 9","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12470463/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145149086","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Differences in the Early <i>In Vitro</i> Development of Preimplantation Human IVF Embryos Which Go on to Develop Congenital Heart Disease.","authors":"Sophie Markham, Alison Campbell, Sue Montgomery, Iain M Dykes","doi":"10.3390/jcdd12090370","DOIUrl":"10.3390/jcdd12090370","url":null,"abstract":"<p><p>There is a clinical need for improved antenatal diagnosis of congenital heart disease (CHD). Increasing numbers of children are born to parents undergoing fertility treatment. We asked whether time-lapse imaging of <i>in vitro</i> preimplantation development provides diagnostic information. We performed a retrospective multicentre analysis of morphokinetic data from patients undergoing fertility treatment. A total of 96/18,799 CHD cases were identified (rate: 0.51%). Thirty-two were included in the analysis and stratified into three cohorts: complex CHD (n = 7), mild CHD (n = 11) and murmur only (n = 14). Comparison to a large unmatched control group (n = 352) revealed no differences in time of preimplantation developmental events but suggested an increase in cleavage synchronicity during the third cell cycle of mild CHD embryos. Pairwise comparison to matched controls revealed a delay in mild CHD embryos relative to controls in reaching the morphokinetic timepoints fading of pronuclei, 2-cell stage and 4-cell stage together with a possible increase in duration of blastulation in complex CHD. Our data raises the possibility that screening of preimplantation embryos at fertility clinics could reduce the rate of CHD. However, these results are preliminary, and further work is required to confirm the findings in a larger study.</p>","PeriodicalId":15197,"journal":{"name":"Journal of Cardiovascular Development and Disease","volume":"12 9","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12471073/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145149198","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sjogren's Disease and Elevated Cardiovascular Risk: Mechanisms and Treatment.","authors":"Jennifer Behbodikhah, Billy Ding, Belin Jacob, Nuzhat Batool, Elise Belilos, Joshua De Leon, Steven E Carsons, Allison B Reiss","doi":"10.3390/jcdd12090367","DOIUrl":"10.3390/jcdd12090367","url":null,"abstract":"<p><p>Autoimmune disorders are known to accelerate atherosclerosis, increasing the rate of cardiovascular disease. As the number one cause of morbidity and mortality in the general population, this risk is only enhanced in inflammatory conditions. Substantial evidence links increased cardiovascular disease to systemic lupus erythematosus and rheumatoid arthritis. However, Sjogren's Disease (SjD) tends to follow a more indolent disease course, and its chronic inflammatory burden is often underrecognized. Pharmacologic agents are also limited and symptom management is often the mainstay of treatment. The majority of studies investigating cardiovascular disease in SjD show conflicting results. In this review, we shed some light on the association of SjD and cardiovascular disease. Furthermore, we also explore potential risk factors and mechanisms through which SjD may accelerate cardiovascular disease. We address the impact of standard CVD and SjD treatments on heart health and highlight clinically relevant tools for monitoring subclinical atherosclerosis in the SjD patient population.</p>","PeriodicalId":15197,"journal":{"name":"Journal of Cardiovascular Development and Disease","volume":"12 9","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12470849/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145149099","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Between Air and Artery: A History of Cardiopulmonary Bypass and the Rise of Modern Cardiac Surgery.","authors":"Vasileios Leivaditis, Andreas Maniatopoulos, Francesk Mulita, Paraskevi Katsakiori, Nikolaos G Baikoussis, Sofoklis Mitsos, Elias Liolis, Vasiliki Garantzioti, Konstantinos Tasios, Panagiotis Leventis, Nikolaos Kornaros, Andreas Antzoulas, Dimitrios Litsas, Levan Tchabashvili, Konstantinos Nikolakopoulos, Manfred Dahm","doi":"10.3390/jcdd12090365","DOIUrl":"10.3390/jcdd12090365","url":null,"abstract":"<p><p>Cardiopulmonary bypass (CPB) is one of the most groundbreaking medical innovations in history, enabling safe and effective heart surgery by temporarily replacing the function of the heart and lungs. This review starts with ancient concepts of cardiopulmonary function and then traces the evolution of CPB through important physiological and anatomical discoveries, culminating in the development of the modern heart-lung machine. In addition to examining the contributions of significant figures like Galen, Ibn al-Nafis, William Harvey, and John Gibbon, we also examine the ethical and technical challenges faced in the early days of open heart surgery. Modern developments are also discussed, such as miniature extracorporeal systems, off-pump surgical techniques, and the increasing importance of extracorporeal membrane oxygenation (ECMO) and extracorporeal life support (ECLS), while the evolving role of perfusionists in diverse cardiac teams and the variations in global access to CPB technology are also given special attention. We look at recent advancements in CPB, including customized methods, nanotechnology, artificial intelligence-guided perfusion, and organ-on-chip testing, emphasizing CPB's enduring significance as a technological milestone and a living example of the cooperation of science, medicine, and human inventiveness because it bridges the gap between the past and the future.</p>","PeriodicalId":15197,"journal":{"name":"Journal of Cardiovascular Development and Disease","volume":"12 9","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12471178/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145149074","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Right Ventricular Phenotyping Can Lead to Pulmonary Vascular Therapy Response in Those with Pulmonary Hypertension with COPD: A Single-Center Cohort Study.","authors":"Oluwafeyijimi Salako, Abhishek Singh","doi":"10.3390/jcdd12090366","DOIUrl":"10.3390/jcdd12090366","url":null,"abstract":"<p><p>Pulmonary hypertension (PH) with chronic obstructive pulmonary disease (COPD) is associated with poor survival with no approved therapies. We report on the response to inhaled treprostinil (iTRE) of a small retrospective cohort of PH-COPD patients with a baseline \"PH-right ventricular (RV) phenotype\", defined by a RV-dependent circulatory limitation derived from a combination of echocardiographic and hemodynamic criteria. Patients were started on inhaled treprostinil with significant improvement in six-minute walk distance, NT-proBNP, and improved RV metrics by echocardiography. The preliminary findings of this cohort provide evidence for the importance of precision phenotyping of PH-COPD.</p>","PeriodicalId":15197,"journal":{"name":"Journal of Cardiovascular Development and Disease","volume":"12 9","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12470605/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145149096","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Early and 3-Year Outcomes of Frozen Elephant Trunk Procedure with Evolving E-vita Hybrid Grafts: A Retrospective Single-Centre Cohort Study over 11 Years.","authors":"Isabelle Doll, Christoph Salewski, Luise Vöhringer, Michael Baumgaertner, Attila Nemeth, Christian Schlensak, Medhat Radwan","doi":"10.3390/jcdd12090368","DOIUrl":"10.3390/jcdd12090368","url":null,"abstract":"<p><strong>Background/objectives: </strong>The frozen elephant trunk (FET) technique is a cornerstone procedure for complex thoracic aortic pathologies. This single-center retrospective study evaluates early and midterm outcomes of total arch replacement (TAR) using three generations of the E-vita Open hybrid prosthesis over 11 years.</p><p><strong>Methods: </strong>From January 2013 to June 2024, 51 patients underwent TAR with the FET technique using the E-vita Open prostheses. Exclusion criteria were isolated ascending or descending aortic replacement, partial arch replacement, TAR without FET, and use of other stent grafts. We analyzed outcomes including in-hospital mortality, survival, stroke, spinal cord injury, and renal complications across three prosthesis generations.</p><p><strong>Results: </strong>The cohort included 52.9% males, with a mean age of 61.5 ± 10.51 years. FET as reoperation was performed in 52.9% patients. In-hospital mortality was 7.8% and, unexpectedly, only occurred with the newest E-vita Open Neo (23.5%), despite this being the latest generation. Overall survival was 72.5% at one year, 60.8% at two years, and 54.9% at three years. Stroke occurred in 17.6% with marked variation by pathology: 0% in dissection, 31.6% in aneurysm, and 13.6% in combined disease. Spinal cord injury occurred in 7.8%. Re-operation was a significant risk factor for complications and was strongly associated with renal complications (85.7% of dialysis patients) but not mortality. Secondary endovascular procedures were required in 49% of patients.</p><p><strong>Conclusions: </strong>The FET technique with E-vita Open prostheses demonstrates acceptable outcomes in high-risk patients with complex aortic pathologies. While perioperative morbidity is significant, particularly in reoperative cases, it varies significantly by underlying pathology and prosthesis generation, with unexpected trends suggesting that technological advancement does not automatically translate into improved outcomes. Despite this, the procedure enables comprehensive management of extensive aortic disease through a staged approach.</p>","PeriodicalId":15197,"journal":{"name":"Journal of Cardiovascular Development and Disease","volume":"12 9","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12471099/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145149205","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of Pan-Immune-Inflammation Value with All-Cause and Cardiovascular Mortality in Survivors of Myocardial Infarction: NHANES 2001-2018 Analysis.","authors":"Qingyi Liu, Wenling Yang, Ruiyu Zhang, Xiaopeng Guo, Yumiao Wei","doi":"10.3390/jcdd12090363","DOIUrl":"10.3390/jcdd12090363","url":null,"abstract":"<p><strong>Background: </strong>Inflammatory responses critically impact long-term outcomes in myocardial infarction (MI) survivors, yet few biomarkers comprehensively evaluate systemic immune-inflammatory status. This study assessed the prognostic utility of a novel marker-the pan-immune-inflammation value (PIV)-for predicting all-cause and cardiovascular mortality post-MI.</p><p><strong>Methods: </strong>Using the National Health and Nutrition Examination Survey data (2001-2018), 1559 MI survivors were included. PIV was calculated as (neutrophils × platelets × monocytes)/lymphocytes. Weighted Cox models assessed the association between log-transformed PIV (LnPIV) and mortality. Restricted cubic spline (RCS) models explored non-linear dose-response relationships, and predictive performance was evaluated via time-dependent ROC analysis.</p><p><strong>Results: </strong>Over a median 75-month follow-up, 675 deaths occurred. LnPIV showed significant non-linear associations with all-cause (<i>p</i> < 0.0001) and cardiovascular mortality (<i>p</i> = 0.0471). When LnPIV ≥ 5.59, each unit increase was associated with an 85% (HR = 1.85, 95% CI: 1.49-2.28) higher all-cause mortality risk; for cardiovascular mortality, the risk increased by 77% (HR = 1.77, 95% CI: 1.20-2.63) when LnPIV ≥ 5.68. Time-dependent ROC analysis confirmed strong prediction above these thresholds.</p><p><strong>Conclusion: </strong>PIV demonstrates threshold-dependent mortality risk stratification in MI patients, particularly effective in high-inflammatory subgroups, offering a potential tool for personalized risk stratification.</p>","PeriodicalId":15197,"journal":{"name":"Journal of Cardiovascular Development and Disease","volume":"12 9","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12470339/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145149122","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}