{"title":"Narrative Review of High-Intensity Interval Training: Positive Impacts on Cardiovascular Health and Disease Prevention.","authors":"Jae-Myun Ko, Wi-Young So, Sung-Eun Park","doi":"10.3390/jcdd12040158","DOIUrl":"https://doi.org/10.3390/jcdd12040158","url":null,"abstract":"<p><strong>Background: </strong>High-intensity interval training (HIIT) has gained recognition for its positive impacts on cardiovascular (CV) health, metabolic outcomes, mental health, and quality of life (QoL). This narrative review aims to comprehensively evaluate the efficacy of HIIT in enhancing CV health and preventing CV disease (CVD).</p><p><strong>Methods: </strong>A comprehensive search of PubMed identified 257 articles, of which 39 studies met predefined inclusion and exclusion criteria for quality assessment. Key metrics evaluated included blood pressure, vascular function, lipid profiles, body composition, and CRF.</p><p><strong>Results: </strong>HIIT significantly improved vascular function, evidenced by reductions in systolic and diastolic blood pressure and enhanced flow-mediated dilation. Improvements in cardiac function were observed through increased cardiac output and heart rate variability. Additionally, HIIT positively influenced lipid profiles, decreasing low-density lipoprotein and triglycerides while increasing high-density lipoprotein. Significant reductions in body fat and improvements in VO<sub>2</sub>peak were noted, contributing to enhanced CRF. HIIT also positively impacted mental health and QoL, reducing anxiety and depressive symptoms. Importantly, HIIT was safely and effectively applied to high-risk populations-individuals with obesity, metabolic syndrome, CVD, and cancer survivors-with a low incidence of adverse effects.</p><p><strong>Conclusions: </strong>This review highlights HIIT as an effective and safe exercise modality for improving CV health, metabolic indicators, mental health, and QoL. Future research should focus on developing tailored HIIT protocols to optimize adherence and efficacy across diverse populations, considering variations in age, sex, health status, and underlying medical conditions.</p>","PeriodicalId":15197,"journal":{"name":"Journal of Cardiovascular Development and Disease","volume":"12 4","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12027975/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144002172","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Ioannis Kyriakoulis, Sriram S Kumar, Georgios D Lianos, Dimitrios Schizas, Damianos G Kokkinidis
{"title":"Coronary Computed Angiography and Coronary Artery Calcium Score for Preoperative Cardiovascular Risk Stratification in Patients Undergoing Noncardiac Surgery.","authors":"Ioannis Kyriakoulis, Sriram S Kumar, Georgios D Lianos, Dimitrios Schizas, Damianos G Kokkinidis","doi":"10.3390/jcdd12040159","DOIUrl":"https://doi.org/10.3390/jcdd12040159","url":null,"abstract":"<p><p>Perioperative and long-term postoperative major adverse cardiovascular events (MACE) are a leading cause of morbidity and mortality in patients undergoing noncardiac surgery. In selected high-risk patients, when information about cardiovascular status may influence surgical decisions, preoperative risk stratification is reasonable, with stress imaging being the preferred method. Coronary computed angiography (CCTA) and coronary artery calcium score (CACS) offer direct anatomical assessment of atherosclerotic coronary arteries and help gauge the extent and severity of coronary artery disease. Strong evidence supports that CCTA and CACS, either alone or in combination, are reliable methods for assessing the risk of both perioperative and long-term postoperative MACE, often demonstrating equal or superior prognostic performance compared to traditional imaging tools. Moreover, integrating CCTA or CACS into standard preoperative imaging protocols further enhances perioperative risk prediction and improves the ability to accurately stratify patients. Future research is needed to better define the role of CCTA and CACS in preoperative cardiovascular risk evaluation of patients undergoing noncardiac surgery.</p>","PeriodicalId":15197,"journal":{"name":"Journal of Cardiovascular Development and Disease","volume":"12 4","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12027494/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144003202","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Velimir Perić, Mlađan Golubović, Marija Stošić, Dragan Milić, Lela Lazović, Dalibor Stojanović, Milan Lazarević, Dejan Marković, Dragana Unić-Stojanović
{"title":"Echocardiographic Predictors of Postoperative Atrial Fibrillation After Cardiac Surgery: Assessing Atrial Mechanics for Risk Stratification.","authors":"Velimir Perić, Mlađan Golubović, Marija Stošić, Dragan Milić, Lela Lazović, Dalibor Stojanović, Milan Lazarević, Dejan Marković, Dragana Unić-Stojanović","doi":"10.3390/jcdd12040160","DOIUrl":"https://doi.org/10.3390/jcdd12040160","url":null,"abstract":"<p><p>Postoperative atrial fibrillation (POAF) is a common complication after cardiac surgery, increasing morbidity and healthcare costs. This study aimed to identify echocardiographic predictors of POAF to improve risk stratification. A total of 131 patients undergoing cardiac surgery were analyzed and divided into two groups based on POAF occurrence. Echocardiographic analysis showed that patients with POAF had larger left and right atrial dimensions and impaired atrial function. Prolonged total atrial conduction time (TACT), reduced atrial emptying volumes, and contractile function were more common in the POAF group. Univariable analysis identified LAEF (χ<sup>2</sup> = 71.8, <i>p</i> < 0.001), LAKE (χ<sup>2</sup> = 70.1, <i>p</i> < 0.001), RATEF (χ<sup>2</sup> = 65.7, <i>p</i> < 0.001), and RAAEF (χ<sup>2</sup> = 66.8, <i>p</i> < 0.001) as significant predictors of POAF, each with an area under the curve (AUC) greater than 0.89. In multivariable analysis, LAKE (OR = 0.27, <i>p</i> < 0.001), hypertension (OR = 11.87, <i>p</i> = 0.035), left ventricular ejection fraction (OR = 1.08, <i>p</i> = 0.020), and peripheral vascular disease (OR = 40.28, <i>p</i> = 0.002) were independent predictors. The final model showed a significant discriminatory ability (AUC = 0.94). LAKE and clinical factors remained independent predictors after adjustment.</p>","PeriodicalId":15197,"journal":{"name":"Journal of Cardiovascular Development and Disease","volume":"12 4","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12027934/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144003110","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Chayakrit Krittanawong, Song Peng Ang, Neil Sagar Maitra, Zhen Wang, Mahboob Alam, Hani Jneid, Samin Sharma
{"title":"Intravascular Imaging-Guided Versus Angiography-Guided Percutaneous Coronary Intervention in Patients with Non-ST-Segment Elevation Myocardial Infarction in the United States: Results from Big Data Analysis.","authors":"Chayakrit Krittanawong, Song Peng Ang, Neil Sagar Maitra, Zhen Wang, Mahboob Alam, Hani Jneid, Samin Sharma","doi":"10.3390/jcdd12040161","DOIUrl":"https://doi.org/10.3390/jcdd12040161","url":null,"abstract":"<p><p>Non-ST-segment elevation myocardial infarction (NSTEMI) can be managed by ischemia guide strategies or early invasive strategies. Here, we present the findings of an updated contemporary analysis regarding the use of intracoronary imaging (ICI)-guided PCI versus angiography-guided PCI and in-hospital mortality in patients with NSTEMI in the United States using the NIS database from 2016 to 2021. ICI use increased by nearly threefold between 2016 and 2021, without a significant difference in in-hospital mortality, though interestingly, mortality rates compared with angiography guidance were similar and relatively low. In this study, the use of ICI was associated with lower adjusted odds of in-hospital mortality, cardiogenic shock, and cardiac arrest, but with a longer length of stay and cost of hospitalization.</p>","PeriodicalId":15197,"journal":{"name":"Journal of Cardiovascular Development and Disease","volume":"12 4","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12027885/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144023333","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Jared B Hinton, Jalal S Jwayyed, Sonum Jagetia, Hunter J Landwehr, John D Scrocco
{"title":"Non-ST-Elevation Myocardial Infarction as the Initial Manifestation of Calreticulin-Positive Essential Thrombocythemia: A Case Report.","authors":"Jared B Hinton, Jalal S Jwayyed, Sonum Jagetia, Hunter J Landwehr, John D Scrocco","doi":"10.3390/jcdd12040157","DOIUrl":"https://doi.org/10.3390/jcdd12040157","url":null,"abstract":"<p><p>Essential thrombocythemia (ET) is a rare myeloproliferative neoplasm characterized by excessive platelet production and a predisposition to thrombotic or hemorrhagic complications. We report a case of a 62-year-old male with no conventional cardiovascular risk factors who presented with a non-ST-segment elevation myocardial infarction (NSTEMI). Initial coronary angiography showed isolated proximal LAD stenosis. Laboratory tests revealed marked thrombocytosis (>1,000,000/μL) and a CALR mutation, confirming a diagnosis of ET. The patient was treated with percutaneous coronary intervention (PCI), dual antiplatelet therapy, and cytoreductive therapy with hydroxyurea, leading to a favorable outcome. This case illustrates how ET, particularly CALR-mutated subtypes, can manifest as acute coronary syndrome in the absence of atherosclerosis and underscores the need to consider hematologic malignancies in atypical presentations of myocardial infarction.</p>","PeriodicalId":15197,"journal":{"name":"Journal of Cardiovascular Development and Disease","volume":"12 4","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12027719/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144010937","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Stefani Samples, Sara Cherny, Nitin Madan, Jeff Hong, Sheena A Mansukhani, Janette F Strasburger, Michael R Carr, Sheetal R Patel
{"title":"The Prenatal Diagnosis and Perinatal Management of Congenital Long QT Syndrome: A Comprehensive Literature Review and Recent Updates.","authors":"Stefani Samples, Sara Cherny, Nitin Madan, Jeff Hong, Sheena A Mansukhani, Janette F Strasburger, Michael R Carr, Sheetal R Patel","doi":"10.3390/jcdd12040156","DOIUrl":"https://doi.org/10.3390/jcdd12040156","url":null,"abstract":"<p><p>Congenital long QT syndrome (LQTS) is a group of heritable conditions that are associated with cardiac repolarization abnormalities characterized by QT prolongation on electrocardiogram and the risk of life-threatening arrhythmias. The prenatal detection of LQTS presents significant challenges for clinicians, and a multidisciplinary approach is required for optimal prenatal and postnatal management. In this comprehensive literature review, we describe strategies for the fetal diagnosis of LQTS with variable initial presentation, genetic testing in suspected fetal LQTS, the utility of fetal magnetocardiography as an additional diagnostic tool, prenatal management, and postnatal treatment. We focus on a multidisciplinary team approach including fetal cardiology, adult and pediatric electrophysiology, neonatology, maternal-fetal medicine, and genetic counselors, all playing vital roles in the comprehensive prenatal management and orchestration of postnatal treatment to optimize neonatal outcomes.</p>","PeriodicalId":15197,"journal":{"name":"Journal of Cardiovascular Development and Disease","volume":"12 4","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-04-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12027825/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144019327","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Marco Zuin, Chiara Tognola, Alessandro Maloberti, Gianfranco Parati, Stefania Angela Di Fusco, Vered Gil Ad, Donatella Armata, Chiara Dalla Valle, Furio Colivicchi, Claudio Bilato, Massimo Grimaldi, Fabrizio Oliva, Pier Luigi Temporelli
{"title":"Advances in Hypertension Management: Insights from the Latest European Guidelines.","authors":"Marco Zuin, Chiara Tognola, Alessandro Maloberti, Gianfranco Parati, Stefania Angela Di Fusco, Vered Gil Ad, Donatella Armata, Chiara Dalla Valle, Furio Colivicchi, Claudio Bilato, Massimo Grimaldi, Fabrizio Oliva, Pier Luigi Temporelli","doi":"10.3390/jcdd12040155","DOIUrl":"https://doi.org/10.3390/jcdd12040155","url":null,"abstract":"<p><p>Arterial hypertension is one of the most common and preventable risk factors for cardiovascular disease and its related mortality. Currently, the prevalence of hypertension in different European countries appears to be around 30-45% of the general population, with a steep increase with ageing. Recent European guidelines have introduced novel recommendations for the management and treatment of hypertensive patients, with direct implications in daily clinical practice. Therefore, in this focused review, we will provide answers to the most common questions regarding the diagnosis, management and treatment of arterial hypertension according to the latest available European guidelines.</p>","PeriodicalId":15197,"journal":{"name":"Journal of Cardiovascular Development and Disease","volume":"12 4","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-04-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12027560/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143967208","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Merna Hussien, Francisca Bermudez, Patrick T Bering, Gaby Weissman, Allison G Hays, Farooq H Sheikh
{"title":"Cardiac Magnetic Resonance Imaging in the Evaluation and Prognosis of Infiltrative Cardiomyopathies.","authors":"Merna Hussien, Francisca Bermudez, Patrick T Bering, Gaby Weissman, Allison G Hays, Farooq H Sheikh","doi":"10.3390/jcdd12040154","DOIUrl":"https://doi.org/10.3390/jcdd12040154","url":null,"abstract":"<p><p>Advancements in cardiac magnetic resonance (CMR) imaging quality and availability have made it an essential tool in the care of individuals living with cardiomyopathies. CMR complements clinical suspicion, electrocardiogram patterns, and echocardiographic findings to help elucidate the etiology of cardiomyopathies and can also be used to prognosticate and follow treatment responses. In this review, we highlight the common CMR findings in cardiac amyloidosis, cardiac sarcoidosis, iron overload cardiomyopathy, and Fabry disease. We also summarize prognostic findings and additional potential roles for CMR in the management of infiltrative cardiomyopathies.</p>","PeriodicalId":15197,"journal":{"name":"Journal of Cardiovascular Development and Disease","volume":"12 4","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-04-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12028063/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144009399","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Shing Ching, Jeffrey Ji-Peng Li, Stefanie Maria Werhahn, Rebecca Elisabeth Beyer, Misael Estepa, Christian Stehning, Djawid Hashemi, Natalia Solowjowa, Christoph Klein, Henryk Dreger, Sebastian Kelle, Patrick Doeblin
{"title":"Right Ventricular and Left Atrial Strain Predict Volumetric Response to Cardiac Resynchronization Therapy.","authors":"Shing Ching, Jeffrey Ji-Peng Li, Stefanie Maria Werhahn, Rebecca Elisabeth Beyer, Misael Estepa, Christian Stehning, Djawid Hashemi, Natalia Solowjowa, Christoph Klein, Henryk Dreger, Sebastian Kelle, Patrick Doeblin","doi":"10.3390/jcdd12040152","DOIUrl":"https://doi.org/10.3390/jcdd12040152","url":null,"abstract":"<p><strong>Background: </strong>While left-bundle-branch-block-related contraction patterns as well as echocardiography-derived strain are variably associated with the volumetric response to cardiac resynchronization therapy (CRT), the role of CMR-derived strain parameters is unexplored.</p><p><strong>Methods: </strong>A total of 50 patients receiving CRT implantation were retrospectively analyzed, all of whom had undergone CMR imaging within one year before, and echocardiography within 6 months before and 6-12 months after CRT implantation. We assessed CMR-derived morphological and functional parameters with regard to the echocardiographic response, defined as a reduction in the left ventricular end-systolic volume of ≥15%.</p><p><strong>Results: </strong>Among the standard CMR parameters, the indexed right ventricular volumes in end-diastole (RVEDVi) (74.5 ± 19.5 vs. 94.8 ± 30.2 mL/m<sup>2</sup>, <i>p</i> = 0.006) and end-systole (RVESVi) (43.2 ± 13.3 vs. 61.6 ± 28.8 mL/m<sup>2</sup>, <i>p</i> = 0.003), as well as the left atrial (LA) area (24.8 ± 3.5 vs. 30.4 ± 9.5 cm<sup>2</sup>, <i>p</i> = 0.020), differed significantly between CRT responders and non-responders. In strain analysis, CRT responders showed a significantly better LA global longitudinal strain (GLS) (25.1 ± 10.4 vs. 15.3 ± 10.5, <i>p</i> = 0.002), LA global circumferential strain (GCS) (27.9 ± 14.7 vs. 17.1 ± 13.1%, <i>p</i> = 0.012), RV GLS (-25.0 ± 6.5 vs. -18.9 ± 7.6%, <i>p</i> = 0.004) and RV free wall strain (-31.1 ± 7.9 vs. -24.9 ± 9.5, <i>p</i> = 0.017).</p><p><strong>Conclusions: </strong>CMR-derived peak septal circumferential strain and RVEDVi correlated with the echocardiographic volumetric response to CRT at 6-12 months.</p>","PeriodicalId":15197,"journal":{"name":"Journal of Cardiovascular Development and Disease","volume":"12 4","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-04-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12027857/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144016608","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Michele D'Alonzo, Lorenzo Di Bacco, Antonio Fiore, Massimo Baudo, Francesca Zanin, Chiara Baldelli, Cyrus Moini, Thierry Folliguet, Claudio Muneretto
{"title":"The Dilemma of Surgical Timing in Acute Aortic Valve Endocarditis: Does Early Surgery Improve Risks or Prognosis?","authors":"Michele D'Alonzo, Lorenzo Di Bacco, Antonio Fiore, Massimo Baudo, Francesca Zanin, Chiara Baldelli, Cyrus Moini, Thierry Folliguet, Claudio Muneretto","doi":"10.3390/jcdd12040153","DOIUrl":"https://doi.org/10.3390/jcdd12040153","url":null,"abstract":"<p><strong>Background: </strong>Acute aortic valve infective endocarditis (IE) presents a critical surgical timing dilemma. This study investigates whether early surgical intervention (within seven days of targeted antibiotic therapy initiation) affects mortality and clinical outcomes compared to delayed/conventional surgery.</p><p><strong>Methods: </strong>A retrospective, multicenter analysis of 204 patients with aortic IE was conducted, excluding emergency cases requiring immediate intervention. Patients were stratified into EARLY (≤7 days) and LATE (>7 days) surgical groups. Primary endpoints included in-hospital mortality and major adverse events, while secondary endpoints assessed long-term survival, recurrence, and reintervention rates.</p><p><strong>Results: </strong>No significant differences in in-hospital mortality were observed between groups (16% in both). The LATE group exhibited a trend toward increased permanent pacemaker implantation (16% vs. 8.2%; <i>p</i> = 0.100) and a higher incidence of postoperative atrial fibrillation (36% vs. 24%, <i>p</i> = 0.048). Infective endocarditis recurrence and long-term survival did not significantly differ between groups. Predictors of one-year mortality included chronic kidney disease, annular abscess, extracorporeal membrane oxygenation (ECMO) use, and prolonged mechanical ventilation.</p><p><strong>Conclusions: </strong>These findings suggest that early surgery, following a short course of antibiotics, does not compromise outcomes nor increase recurrence risk, challenging the conventional preference for delayed intervention in non-emergency IE cases.</p>","PeriodicalId":15197,"journal":{"name":"Journal of Cardiovascular Development and Disease","volume":"12 4","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-04-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12028007/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143967948","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}