A Sphincter-like Function of Pulmonary Vein Ostia in Normal and Atrial Fibrillation Subjects.

IF 2.4 4区医学 Q2 CARDIAC & CARDIOVASCULAR SYSTEMS

Journal of Cardiovascular Development and Disease Pub Date : 2025-05-28 DOI:10.3390/jcdd12060203

Stefano Bonapace, Matteo Falanga, Carmelo Cicciò, Cristiana Corsi, Giulio Molon

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引用次数: 0

Abstract

Background: Early anatomical study suggested that the pulmonary vein (PVs) junction may have putative sphincter-like activity. The aim of this study was to evaluate this activity in normal and paroxysmal/persistent atrial fibrillation subjects.

Methods: The Cardiac Computed Tomography (CCT) scans of 45 subjects [15 normal controls, 15 patients with paroxysmal atrial fibrillation (PAR-AF), and 15 with persistent AF (PER-AF)] were retrospectively analyzed. All subjects were in sinus rhythm during the CCT scan. A 3D anatomical model was developed, enabling us to identify the PV ostia and to measure their area dynamic changes during the cardiac cycle.

Results: The area changes in the superior PVs within the three groups were significantly higher compared to the inferior (control p = 0.007, PAR-AF p = 0.0003, PER-AF p = 0.04). Moreover, these variations were significantly reduced in PAR-AF and PER-AF compared to the control in all PVs (LSPV (p < 0.001), RSPV (p < 0.001), RIPV (p = 0.037), and LIPV (p < 0.001)).

Conclusions: This sphincter-like activity, most prominent in superior PVs, is progressively impaired in patients with paroxysmal and persistent AF.

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正常人和房颤患者肺静脉口的括约肌样功能。

背景：早期解剖研究提示肺静脉（pv）连接处可能有类似括约肌的活动。本研究的目的是评估正常和阵发性/持续性心房颤动受试者的这种活动。方法：回顾性分析45例患者（15例正常对照，15例阵发性心房颤动（PAR-AF）， 15例持续性心房颤动（PER-AF））的心脏计算机断层扫描（CCT）。所有受试者在CCT扫描时均处于窦性心律。建立了三维解剖模型，使我们能够识别PV口并测量其在心脏周期内的面积动态变化。结果：三组上侧pv面积变化均显著高于下侧pv （control p = 0.007, PAR-AF p = 0.0003, PER-AF p = 0.04）。此外，与对照组相比，所有pv (LSPV (p < 0.001), RSPV （p < 0.001), RIPV （p = 0.037）和LIPV (p < 0.001)）的PAR-AF和PER-AF的这些变异显著减少。结论：在阵发性和持续性房颤患者中，这种约括肌样活动（在上pv中最为突出）逐渐受损。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Cardiovascular Development and Disease CARDIAC & CARDIOVASCULAR SYSTEMS-

CiteScore

2.60

自引率

12.50%

发文量

381