Journal of Cardiovascular Development and Disease最新文献_第7页

Echocardiographic Assessment of Pulmonary Hemodynamics and Right Ventricular Performance in Neonatal Murine Hypoxia. 新生儿缺氧小鼠肺血流动力学和右心室功能的超声心动图评价。

IF 2.3 4区医学

Journal of Cardiovascular Development and Disease Pub Date : 2025-08-19 DOI: 10.3390/jcdd12080316

Kel Vin Woo, Philip T Levy, Carla J Weinheimer, Amanda L Hauck, Aaron Hamvas, David M Ornitz, Attila Kovacs, Gautam K Singh

{"title":"Echocardiographic Assessment of Pulmonary Hemodynamics and Right Ventricular Performance in Neonatal Murine Hypoxia.","authors":"Kel Vin Woo, Philip T Levy, Carla J Weinheimer, Amanda L Hauck, Aaron Hamvas, David M Ornitz, Attila Kovacs, Gautam K Singh","doi":"10.3390/jcdd12080316","DOIUrl":"10.3390/jcdd12080316","url":null,"abstract":"Background: Right heart catheterization (RHC) is the gold-standard for diagnosis of pulmonary hypertension (PH) but is a terminal procedure in neonatal mice. The objective was to validate echocardiographic measures of PH to establish the diagnostic capability against pulmonary vascular histology in neonatal mice. Methods: Adult mice, exposed to hypoxia or normoxia, were assessed by echocardiography and RHC to evaluate right ventricle (RV) morphometry and function. Echocardiographic measures identified in adult mice were then used to evaluate PH characteristics in hypoxia-exposed neonatal mice. Physiological parameters were compared to histopathology in all mice. Results: Hypoxia-challenged adult mice developed PH with RHC, demonstrating confirmed elevated RV systolic pressure (RVSP), RV hypertrophy, and increased cross-sectional area and neomuscularization of pulmonary vessels. Echocardiography-derived RV free wall (RVFW) thickness correlated with RV mass. Tricuspid valve annulus tissue Doppler imaging (TV TDI), tricuspid annular plane systolic excursion (TAPSE), pulmonary artery acceleration measures (PAAT), and TAPSE × PAAT (a measure of RV work) all correlated with RVSP determined by RHC. In neonatal mice exposed to hypoxia, PAAT, TV TDI, TAPSE, and TAPSE × PAAT were decreased and RVFW thickness was increased, correlating with the histologic phenotype of PH. Conclusions: Echocardiographic indices of RV morphology and function provide reliable estimates of invasive RV hemodynamics in hypoxia-induced PH.","PeriodicalId":15197,"journal":{"name":"Journal of Cardiovascular Development and Disease","volume":"12 8","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-08-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12386579/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144955310","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Mitral Annular Disjunction: Epidemiology, Diagnostic Methods, Prognosis, and Novel Implications. 二尖瓣环分离：流行病学、诊断方法、预后和新意义。

IF 2.3 4区医学

Journal of Cardiovascular Development and Disease Pub Date : 2025-08-18 DOI: 10.3390/jcdd12080311

Vasileios Tsimpiris, Georgia Kousourna, Aristi Boulmpou, Magdalini Petridou, Chalil Tsavousoglou, Dimitrios Kotzadamis, Christodoulos Papadopoulos, Dimitrios Ntelios, Theodoros Moysiadis, Vassilios Vassilikos, Efstathios Pagourelias

{"title":"Mitral Annular Disjunction: Epidemiology, Diagnostic Methods, Prognosis, and Novel Implications.","authors":"Vasileios Tsimpiris, Georgia Kousourna, Aristi Boulmpou, Magdalini Petridou, Chalil Tsavousoglou, Dimitrios Kotzadamis, Christodoulos Papadopoulos, Dimitrios Ntelios, Theodoros Moysiadis, Vassilios Vassilikos, Efstathios Pagourelias","doi":"10.3390/jcdd12080311","DOIUrl":"10.3390/jcdd12080311","url":null,"abstract":"Mitral annular disjunction (MAD) is an increasingly recognized structural abnormality of the mitral valve apparatus, often associated with mitral valve prolapse and a heightened risk of ventricular arrhythmias and sudden cardiac death. It is defined by a separation between the mitral annulus and the left ventricular myocardium, best visualized during systole. In this review, we present an updated and comprehensive overview of MAD, drawing from recent large-scale imaging studies, expert consensus documents, and newly proposed classifications such as true versus pseudo-MAD. We discuss its prevalence, anatomical features, and diagnostic challenges across multiple imaging modalities, including transthoracic and transesophageal echocardiography, cardiovascular magnetic resonance, and computed tomography. We also explore its pathophysiological role in arrhythmogenesis, its prognostic implications, and current management strategies. Special attention is given to risk stratification based on imaging and cardiac rhythm findings, and we propose a practical clinical framework to guide decision-making. This review aims to support clinicians in recognizing MAD as a potentially arrhythmogenic condition that requires systematic evaluation and follow-up.","PeriodicalId":15197,"journal":{"name":"Journal of Cardiovascular Development and Disease","volume":"12 8","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-08-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12387043/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144955559","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Late Gadolinium Enhancement Variation in Asymptomatic Individuals: Comparison with Dilated Cardiomyopathy. 无症状个体的晚期钆增强变化：与扩张型心肌病的比较。

IF 2.3 4区医学

Journal of Cardiovascular Development and Disease Pub Date : 2025-08-18 DOI: 10.3390/jcdd12080312

Seoyeon Park, Soo Jin Cho, Sung Mok Kim, Moon Young Kim, Yeon Hyeon Choe

{"title":"Late Gadolinium Enhancement Variation in Asymptomatic Individuals: Comparison with Dilated Cardiomyopathy.","authors":"Seoyeon Park, Soo Jin Cho, Sung Mok Kim, Moon Young Kim, Yeon Hyeon Choe","doi":"10.3390/jcdd12080312","DOIUrl":"10.3390/jcdd12080312","url":null,"abstract":"Late gadolinium enhancements (LGEs) appear in asymptomatic individuals as septal stripes, which mimic abnormal LGEs in patients with dilated cardiomyopathy (DCM). We aimed to evaluate the frequency and extent of LGE variation in asymptomatic individuals and to compare it with those of DCM group. This retrospective study included asymptomatic and DCM groups who underwent CMR imaging. LGE was defined as a myocardial signal intensity higher than five standard-deviations of normal myocardium. LGE was evaluated in right ventricular insertion points (RVIPs) and mid-interventricular septum. A total of 273 asymptomatic individuals (age, 54.3 ± 5.8 years, 209 males) and 100 patients with DCM (age, 55.3 ± 4.9 years, 73 males) were included. LGE was observed in 99.3% of asymptomatic and 100% of DCM groups. The average number of myocardial segments with LGE was distinguishable between asymptomatic and DCM groups (5.5 ± 1.7 vs. 7.6 ± 2.2; p < 0.001). The thickness of LGE differed between two groups in mid-septum (4.5 ± 1.3 mm vs. 5.7 ± 1.8 mm; p < 0.001), upper RVIP (6.1 ± 1.9 mm vs. 8.7 ± 2.7 mm; p < 0.001), and lower RVIP (6.4 ± 2.3 mm vs. 8.6 ± 2.8 mm; p < 0.001). Considerable overlap was observed in LGE between asymptomatic and DCM groups despite different LGE characteristics between them. LGEs within normal range should not be interpreted as abnormal findings in the evaluation of myocardial diseases including DCM.","PeriodicalId":15197,"journal":{"name":"Journal of Cardiovascular Development and Disease","volume":"12 8","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-08-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12386344/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144955389","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Feature Review Papers in Stroke and Cerebrovascular Disease. 脑卒中与脑血管病特刊综述。

IF 2.3 4区医学

Journal of Cardiovascular Development and Disease Pub Date : 2025-08-15 DOI: 10.3390/jcdd12080309

Narayanaswamy Venketasubramanian

引用次数: 0

Atrioventricular Node Dysfunction in Heart Failure: New Horizons from Pathophysiology to Therapeutic Perspectives. 心衰的房室结功能障碍：从病理生理学到治疗角度的新视野。

IF 2.3 4区医学

Journal of Cardiovascular Development and Disease Pub Date : 2025-08-15 DOI: 10.3390/jcdd12080310

Isabella Fumarulo, Elia Nunzio Maria Salerno, Andrea De Prisco, Salvatore Emanuele Ravenna, Maria Chiara Grimaldi, Francesco Burzotta, Nadia Aspromonte

引用次数: 0

Perinatal Socioeconomic Disadvantage and Cardiovascular Comorbidities: National and State-Level Results of a Novel Cardio-Obstetrics Program. 围产期社会经济劣势和心血管合并症：一项新的心产科学计划的国家和州级结果。

IF 2.3 4区医学

Journal of Cardiovascular Development and Disease Pub Date : 2025-08-13 DOI: 10.3390/jcdd12080307

Sakshi Sehgal, Elinita Pollard, Toscha Charles, Marquetta Thomas, Marlo Vernon, Gyanendra Sharma, Chadburn Ray

{"title":"Perinatal Socioeconomic Disadvantage and Cardiovascular Comorbidities: National and State-Level Results of a Novel Cardio-Obstetrics Program.","authors":"Sakshi Sehgal, Elinita Pollard, Toscha Charles, Marquetta Thomas, Marlo Vernon, Gyanendra Sharma, Chadburn Ray","doi":"10.3390/jcdd12080307","DOIUrl":"10.3390/jcdd12080307","url":null,"abstract":"Perinatal cardiovascular disease accounts for nearly one-third of pregnancy-related deaths, with nearly 70% of these deaths preventable with appropriate cardio-obstetric care. The objective is to assess whether socioeconomic disadvantage, utilizing area deprivation index national and state rankings as a proxy, contributes to a higher risk of CV disease during the perinatal period. A single-site retrospective cohort study of 388 electronic health records patients seen at a novel cardio-obstetrics program between June 2022 and May 2024 was conducted. The main exposure was ADI state rankings, and the primary outcome of interest was diagnosis of perinatal CV disease, with secondary measures including preeclampsia, hypertension, and peripartum cardiomyopathy. Multivariable logistic regression models were utilized to examine the association between ADI and perinatal CV disease. National ADI ranking was associated with an increased odds of developing preeclampsia (OR: 2.56, 95% CI: 1.12-5.89) and HTN (OR: 2.37, 95% CI: 1.19-4.72). Socioeconomic disadvantage during the perinatal period is associated with a statistically significant risk of CV disease, including preeclampsia, hypertension, and peripartum cardiomyopathy, as well as any CV diagnosis in general.","PeriodicalId":15197,"journal":{"name":"Journal of Cardiovascular Development and Disease","volume":"12 8","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-08-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12386495/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144955512","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Comparison of Surgical Treatment Outcomes in Patients with Symptomatic Severe Aortic Valve Stenosis Using the Perceval Sutureless Bioprosthesis Versus a Conventional Biological Valve. 无缝线生物假体与传统生物瓣膜在重度症状性主动脉瓣狭窄患者手术治疗效果的比较。

IF 2.3 4区医学

Journal of Cardiovascular Development and Disease Pub Date : 2025-08-13 DOI: 10.3390/jcdd12080308

Dejan M Lazović, Milica Karadžić, Filip Vučićević, Gorica Marić, Miloš Grujić, Ivana Đurošev, Mladen J Kočica, Svetozar Putnik, Dragan Cvetković

{"title":"Comparison of Surgical Treatment Outcomes in Patients with Symptomatic Severe Aortic Valve Stenosis Using the Perceval Sutureless Bioprosthesis Versus a Conventional Biological Valve.","authors":"Dejan M Lazović, Milica Karadžić, Filip Vučićević, Gorica Marić, Miloš Grujić, Ivana Đurošev, Mladen J Kočica, Svetozar Putnik, Dragan Cvetković","doi":"10.3390/jcdd12080308","DOIUrl":"10.3390/jcdd12080308","url":null,"abstract":"Objectives: This single-center retrospective comparative cohort study aimed to compare the outcomes of aortic valve replacement using a Perceval sutureless bioprosthesis versus a conventional stented bioprosthesis in patients with symptomatic severe aortic valve stenosis. Methods: A total of 233 consecutive elective patients undergoing aortic valve replacement (AVR) at the University Clinical Center of Serbia (July 2017-March 2021) were analyzed: 74 received a Perceval sutureless valve, and 159 received a conventional stented valve. Results: The baseline characteristics were similar between the groups, with most patients being male (54.1% vs. 56.6%), with a mean age of 72.6 years. Combined aortic valve replacement and coronary artery bypass grafting were performed in 19.3% of the patients. Mean aortic cross-clamp (ACC) time was significantly shorter in the Perceval group for combined procedures (104.5 ± 29.6 min, p < 0.05) but similar in isolated AVR, likely reflecting the early institutional learning curve. Thirty-day mortality was comparable (5.9% vs. 6.3%). Importantly, at 36 months, survival was higher in the Perceval group (88.3% vs. 76.8%, p = 0.048). Longer echocardiographic follow-up (up to 58 months) was available for the Perceval group. Conclusions: Perceval sutureless bioprostheses are a safe and effective option for elderly high-risk patients. The extended echocardiographic follow-up represents a novel contribution to the literature, although further data on long-term durability are needed.","PeriodicalId":15197,"journal":{"name":"Journal of Cardiovascular Development and Disease","volume":"12 8","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-08-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12387097/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144955363","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Implications of Myocardial Fibrosis Burden on Left Ventricular Systolic Function in Sepsis Survivors: Insights from a Retrospective Cohort Study Using Quantitative Late Gadolinium Enhancement Cardiovascular Magnetic Resonance. 心肌纤维化负担对脓毒症幸存者左心室收缩功能的影响：一项使用定量晚期钆增强心血管磁共振的回顾性队列研究的启示

IF 2.3 4区医学

Journal of Cardiovascular Development and Disease Pub Date : 2025-08-13 DOI: 10.3390/jcdd12080306

Shayan Datta, Samuel Malomo, Thomas Oswald, Claire Phillips, Barbara Philips, Joon Lee, David Hildick-Smith, Victoria Parish, Alexander Liu

{"title":"Implications of Myocardial Fibrosis Burden on Left Ventricular Systolic Function in Sepsis Survivors: Insights from a Retrospective Cohort Study Using Quantitative Late Gadolinium Enhancement Cardiovascular Magnetic Resonance.","authors":"Shayan Datta, Samuel Malomo, Thomas Oswald, Claire Phillips, Barbara Philips, Joon Lee, David Hildick-Smith, Victoria Parish, Alexander Liu","doi":"10.3390/jcdd12080306","DOIUrl":"10.3390/jcdd12080306","url":null,"abstract":"Background: After recovery from acute sepsis, patients can exhibit left ventricular systolic dysfunction (LVSD) and non-ischaemic myocardial fibrosis. The relationship between myocardial fibrosis and LVSD remains poorly defined. This study sought to fill this knowledge gap using quantitative late gadolinium enhancement (LGE) cardiovascular magnetic resonance (CMR). Methods: Twenty-eight sepsis survivors underwent CMR at 1.5-Tesla for the assessment of cardiac volumes, systolic function and LGE. Myocardial fibrosis burden was derived quantitatively by LGE, expressed as a percentage of LV mass. Results: Study patients (age 51 ± 16 years; 57% males) had a median LVEF of 59% (IQR: 43-64) of whom 43% had LVSD (LV ejection fraction [LVEF] < 50%). LGE was found in 64% of the study patients by visual assessment, mostly in non-ischaemic patterns. The overall myocardial fibrosis burden was 3.3% (IQR: 0.9-7.1) of LV mass. Myocardial fibrosis burden was inversely correlated to LVEF in sepsis survivors (Rho = -0.385; p = 0.043). Patients with LVSD had greater myocardial fibrosis burden than patients without LVSD (7.3 ± 6.0% vs. 3.1 ± 2.5%; p = 0.041). Myocardial fibrosis burden was not significantly influenced by the presence of major co-morbidities. Conclusions: Myocardial fibrosis burden may play a role in LV dysfunction in sepsis survivors. Further work is needed to better understand its prognostic value.","PeriodicalId":15197,"journal":{"name":"Journal of Cardiovascular Development and Disease","volume":"12 8","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-08-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12386489/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144955465","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Sex Differences in Stroke Risk Factors and Mechanisms in a Multi-Ethnic Asian Population. 亚洲多种族人群脑卒中危险因素及机制的性别差异。

IF 2.3 4区医学

Journal of Cardiovascular Development and Disease Pub Date : 2025-08-12 DOI: 10.3390/jcdd12080304

Narayanaswamy Venketasubramanian

{"title":"Sex Differences in Stroke Risk Factors and Mechanisms in a Multi-Ethnic Asian Population.","authors":"Narayanaswamy Venketasubramanian","doi":"10.3390/jcdd12080304","DOIUrl":"10.3390/jcdd12080304","url":null,"abstract":"Introduction: Previous studies have reported sex differences in stroke. There are few Asian studies. This study was performed to investigate sex differences in stroke risk factors and mechanisms in a multi-ethnic Asian population.Methods: Data on patients admitted to Raffles Hospital for stroke were analysed. Data were extracted on sex, age, hypertension, diabetes mellitus (DM), hyperlipidaemia, smoking, heart disease, and prior cerebrovascular events (pCeVD). Stroke was subtyped into haemorrhagic stroke (HS) or ischaemic stroke (IS) based on brain scan. IS mechanism was categorised using Trial of Org 10172 in Acute Stroke Treatment (TOAST) classification, while the clinical syndrome by Oxfordshire Community Stroke Project (OCSP) classification.Results: Data were collected on 1165 patients, mean age 65.6 ± 12.9 yr; 47.4% female, 83.0% Chinese, with hypertension (63.5%) and hyperlipidaemia (60.3%) being the most common risk factors. HS comprised 23.5%. On regression analysis, compared to males, females had older age (OR 1.03, 95%CI 1.02-10.4) and DM (OR 1.60, 95%CI 1.11-2.30), but less smoking (OR 0.09, 95%CI 0.07-0.13), pCeVD (OR 0.67, 95%CI 0.49-0.93), and HS (OR 0.71, 95%CI 0.51-0.98). There were no differences in HS mechanisms, or IS mechanisms or syndromes. Sex-ethnic differences were found (p < 0.001), with more Chinese and fewer Indians among females compared to males.Conclusions: This study corroborates previous studies of significantly older age and more diabetes mellitus, but less smoking and haemorrhagic stroke among female stroke patients compared to males; differences in HS and IS mechanisms were not found. Novel in this study is that sex-ethnicity differences were found. Future studies should prospectively validate these sex/ethnic differences.","PeriodicalId":15197,"journal":{"name":"Journal of Cardiovascular Development and Disease","volume":"12 8","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-08-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12386609/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144955578","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Coronary Artery Calcification in Patients with Radiographic Axial Spondyloarthritis: A Comparative Study with Matched Controls in Southwestern Sweden. 放射状轴性脊柱炎患者冠状动脉钙化：瑞典西南部与匹配对照的比较研究。

IF 2.3 4区医学

Journal of Cardiovascular Development and Disease Pub Date : 2025-08-12 DOI: 10.3390/jcdd12080305

Erik Hulander, Anna Deminger, Sofia Enegren, Magnus Hallström, Caroline Feldthusen, Erika Fagman, Oskar Angerås, Tatiana Zverkova Sandström, Mats Geijer, Helena Forsblad-d'Elia

{"title":"Coronary Artery Calcification in Patients with Radiographic Axial Spondyloarthritis: A Comparative Study with Matched Controls in Southwestern Sweden.","authors":"Erik Hulander, Anna Deminger, Sofia Enegren, Magnus Hallström, Caroline Feldthusen, Erika Fagman, Oskar Angerås, Tatiana Zverkova Sandström, Mats Geijer, Helena Forsblad-d'Elia","doi":"10.3390/jcdd12080305","DOIUrl":"10.3390/jcdd12080305","url":null,"abstract":"Radiographic axial spondyloarthritis (r-axSpA) is associated with increased cardiovascular disease (CVD) risk. The coronary artery calcification (CAC) score, an atherosclerosis burden indicator that predicts CVD risk, is not well studied in r-axSpA. This study investigates CAC scores in patients with r-axSpA compared to controls without rheumatic disease and factors associated with CAC scores in r-axSpA patients. Fifty-eight r-axSpA patients from southwestern Sweden were assessed cross-sectionally using clinical disease measures, physical function, spinal mobility, lipid profiles, inflammation markers, and long-term time-averaged C-reactive protein (CRP). Four controls per patient were selected from the Swedish CArdioPulmonary bioImage Study (SCAPIS). CAC was scored on cardiac computed tomography (CT) using the Agatston method. The presence of CAC in the right coronary artery (RCA) was higher in patients compared to controls. However, no significant difference in total CAC scores was observed between r-axSpA patients and controls, despite numerically higher total CAC scores in patients. In r-axSpA patients, CAC scores correlated positively with time-averaged CRP, reduced physical function, and impaired spinal mobility. These findings suggest that chronic inflammation may contribute to coronary calcification and CVD risk in r-axSpA, highlighting the need for effective anti-inflammatory treatments. Further research is warranted to explore the association between coronary calcification, spinal immobility, and limitations in physical function.","PeriodicalId":15197,"journal":{"name":"Journal of Cardiovascular Development and Disease","volume":"12 8","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-08-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12387049/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144955319","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0