Journal of Cardiovascular Development and Disease最新文献

{"title":"Catheter Ablation of Septal Accessory Pathways in Children: A 12-Year Experience at a Tertiary Care Center.","authors":"Ozlem Turan, Celal Akdeniz, Volkan Tuzcu","doi":"10.3390/jcdd12040111","DOIUrl":"https://doi.org/10.3390/jcdd12040111","url":null,"abstract":"<p><p><b>Background</b>: Septal accessory pathways (APs) are challenging ablation targets. This study aims to contribute to the pediatric literature by presenting our long-term experience of septal AP ablations with limited fluoroscopy. <b>Methods</b>: This is a retrospective study of all patients who underwent septal AP ablations from July 2012 to July 2023 at a single center. <b>Results</b>: We identified 298 septal AP connections in 291 (11.8 ± 4.9 years) patients. Seventy-nine (27%) cases were diagnosed with supraventricular tachycardia, and 212 (73%) cases were diagnosed with Wolff-Parkinson-White (WPW). The AP locations were posteroseptal (<i>n</i> = 159; 54%), anteroseptal (<i>n</i> = 86; 30%), and midseptal (<i>n</i> = 46; 16%). Of those diagnosed with WPW, 61 (28%) had high-risk AP, and 90 (40%) were adenosine-responsive. Cryoablation was used in 190 (66%), radiofrequency ablation (RFA) was used in 36 (12.5%), and both were used in 62 (21.5%) patients. The overall acute success rate of initial procedures was 89.6% (the acute success rate of cryoablation = 86.6%, and of RFA = 94.1%). No statistically significant difference was observed between cryoablation and RFA (<i>p</i> = 0.617). During a mean follow-up of 88.5 ± 33.0 months, the overall recurrence rate was 11.3% (cryoablation vs. RFA; <i>p</i> = 0.834), with the highest at the right-posteroseptal location. An irrigated-tip RFA was preferred during redo procedures in 20 (45%) cases. The long-term success rate was 99% when the repeat procedures were considered. No complications were observed. <b>Conclusions</b>: Due to the higher recurrence rates in septal AP ablations compared to other locations, repeated procedures might be needed to achieve definitive long-term success. This study indicates that similar acute and long-term success rates can be achieved with cryoablation compared to RFA, with the significant benefit of increased safety.</p>","PeriodicalId":15197,"journal":{"name":"Journal of Cardiovascular Development and Disease","volume":"12 4","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-03-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12028273/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143985180","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Long-Term Outcomes of Mitral Valve Repair Versus Replacement in Patients with Ischemic Mitral Regurgitation: A Retrospective Propensity-Matched Analysis.","authors":"Ismail M Elnagar, Rawan Alghamdi, Murtadha H Alawami, Ahmad Alshammari, Abdulmalik A Almedimigh, Monirah A Albabtain, Alaa AlGhamdi, Huda H Ismail, Mostafa A Shalaby, Khaled A Alotaibi, Amr A Arafat","doi":"10.3390/jcdd12040109","DOIUrl":"https://doi.org/10.3390/jcdd12040109","url":null,"abstract":"<p><strong>Background: </strong>The optimal surgical management of ischemic mitral regurgitation (IMR)-mitral valve repair (MVr) versus mitral valve replacement (MVR)-remains controversial, with limited evidence on long-term outcomes. This study aimed to compare the outcomes of MVr and MVR in patients with IMR, focusing on survival and recurrence of mitral regurgitation. Additionally, survival was compared based on preoperative characteristics.</p><p><strong>Methods: </strong>A retrospective cohort analysis was conducted at a tertiary referral center and included 759 patients who underwent surgery for IMR between 2009 and 2021. Propensity score matching identified 140 matched pairs. The outcomes assessed included hospital mortality, long-term survival, recurrence of mitral regurgitation, mitral valve reintervention rates, and echocardiographic changes over time.</p><p><strong>Results: </strong>In the matched cohort, no significant differences were observed in hospital mortality (10% for MVr vs. 10.7% for MVR, <i>p</i> > 0.99) or long-term survival (<i>p</i> = 0.534). However, MVr was associated with a higher rate of recurrent moderate or higher mitral regurgitation (29.04% vs. 10.37%, <i>p</i> < 0.001) compared to MVR. The mitral valve reintervention rates did not differ significantly between the groups. Echocardiographic follow-up revealed significant improvements in left ventricular function and dimensions, with no significant differences between the groups. A subgroup analysis revealed no difference in survival according to the age, gender, ejection fraction, EuroSCORE category, or right ventricular function between the MVr and MVR patients.</p><p><strong>Conclusions: </strong>MVr and MVR for IMR yielded comparable survival rates, but MVr was associated with a higher risk of recurrent MR. The efficacy of both surgical approaches across diverse patient populations was comparable, reinforcing the need for individualized decision-making based on other clinical and anatomical considerations.</p>","PeriodicalId":15197,"journal":{"name":"Journal of Cardiovascular Development and Disease","volume":"12 4","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-03-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12027820/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144005522","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Possibilities and Importance of Assessing the Left Atrioventricular Coupling Index Using Various Diagnostic Imaging Methods in an Adult Population: A Comprehensive Review.","authors":"Małgorzata Poręba, Krzysztof Kraik, Igor Zasoński, Oskar Ratajczyk, Łukasz Paździerz, Angelika Chachaj, Rafał Poręba, Paweł Gać","doi":"10.3390/jcdd12040110","DOIUrl":"https://doi.org/10.3390/jcdd12040110","url":null,"abstract":"<p><p>Cardiovascular diseases are a leading cause of death worldwide, and they are becoming even more frequent due to the aging of society. Due to this fact, new parameters that are useful in diagnosing, as well as in assessing, the risk of cardiovascular events, and in future prognosis estimation, should be developed. The left atrioventricular coupling index (LACI) has been recently introduced as the one parameter meeting these criteria. The current review aims to collect all available data and assess whether the LACI may be a valuable tool in daily clinical practice, and, simultaneously, to direct future research on the subject. The LACI is a parameter that can be calculated based on echocardiographic, cardiac CT and CMR examinations. It appears to be of use in several cardiovascular diseases, especially heart failure and atrial fibrillation, both in diagnostics and as a prognostic marker. Moreover, the LACI is a useful marker in cardiomyopathies, myocardial infarction, beta-thalassemia major and light-chain amyloidosis. However, the number of studies on the subject of LACI is limited, and some of these studies are based on the same cohort of patients. Future studies should take up the subject of the LACI, especially when it comes to the value of calculating the LACI based on various imaging techniques, including echocardiography.</p>","PeriodicalId":15197,"journal":{"name":"Journal of Cardiovascular Development and Disease","volume":"12 4","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-03-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12027538/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144009402","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence of Patent Foramen Ovale in Patients with Non-Obstructive Coronary Artery Disease (PROVA) Study.","authors":"Abdelhak El Bouziani, Lars S Witte, Rutger G T Feenstra, Mick P L Renkens, Janneke Woudstra, Jan G P Tijssen, Arja S Vink, Yolande Appelman, Maik J D Grundeken, Bart Straver, Jan J Piek, Berto J Bouma, Robbert J de Winter, Marcel A M Beijk","doi":"10.3390/jcdd12040108","DOIUrl":"https://doi.org/10.3390/jcdd12040108","url":null,"abstract":"<p><p>(1) Background: Prevalence of patent foramen ovale (PFO) in the general population is estimated at around 24%. We hypothesized that right-to-left shunting (RLS) resulting from PFO might contribute to angina symptoms in patients with coronary artery spasm (CAS), potentially triggered by vasoactive metabolites. Therefore, the aim of this study was to investigate the prevalence of PFO-related RLS in patients with documented CAS. (2) Methods: This single-center prospective cohort study included patients with documented CAS undergoing transthoracic echocardiography (TTE), including a contrast bubble study between 2021 and 2023. The Seattle Angina Questionnaire (SAQ) and Migraine Disability Assessment (MIDAS) were used to survey patients. (3) Results: RLS (PFO group) was observed in 11 of the 48 patients included (23%). In the PFO group, 64% had epicardial spasm and 36% microvascular spasm. Furthermore, RLS was more prevalent in patients with CAS and concomitant migraine (29%). Remarkably, the density plot of the SAQ summary score showed a worse score for patients with RLS (median of 38 [Q1-Q3: 31-49]) than patients without RLS (median of 49 [Q1-Q3: 41-55]) (<i>p</i> = 0.0282). (4) Conclusions: The prevalence of RLS due to PFO in patients with CAS was in line with the PFO prevalence in the general population, and patients with RLS are more symptomatic according to the SAQ summary score. Whether PFO closure could be beneficial to patients with CAS and concomitant migraine requires further investigation.</p>","PeriodicalId":15197,"journal":{"name":"Journal of Cardiovascular Development and Disease","volume":"12 4","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12028130/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144001733","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Myocardial Viability: Evolving Insights and Challenges in Revascularization and Functional Recovery.","authors":"Kristoffer Ken Ralota, Jamie Layland, Kyi Thar Han Win, Nay M Htun","doi":"10.3390/jcdd12030106","DOIUrl":"10.3390/jcdd12030106","url":null,"abstract":"<p><p>The prevalence of heart failure, driven significantly by ischemic heart disease, continues to rise globally. Myocardial viability-the potential ability of dysfunctional myocardium to recover contractile function after revascularization-remains an ongoing key area of research in managing ischemic cardiomyopathy. Advances in imaging modalities, including PET/SPECT, cardiac MRI, and dobutamine stress echocardiography, have enabled identification of viable myocardium that can potentially predict their functional recovery following revascularization. Despite these advances, recent evidence from major trials questions the routine reliance on viability testing for revascularization guidance. These studies found a limited correlation between myocardial viability and improved outcomes in key metrics including mortality. Furthermore, they highlighted the effectiveness of guideline-directed medical therapy in improving left ventricular function independent of revascularization. This narrative review explores the concept of myocardial viability, its assessment through contemporary imaging techniques, its clinical utility in decision making for revascularization, and future directions.</p>","PeriodicalId":15197,"journal":{"name":"Journal of Cardiovascular Development and Disease","volume":"12 3","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11943439/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143709861","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comprehensive Self-Management of Heart Failure.","authors":"Shunsuke Kiuchi, Shigeto Tsukamoto, Rie Sato, Keisuke Hosono, Jun Okuda, Makoto Natsumeda, Mitsuharu Kawamura, Hideaki Tachibana, Takashi Okada, Takuro Takagi, Yasushi Taniguchi, Jiro Ando, Yutaka Koyama, Toshiro Shinke, Takanori Ikeda","doi":"10.3390/jcdd12030107","DOIUrl":"10.3390/jcdd12030107","url":null,"abstract":"<p><p>In response to the heart failure (HF) pandemic, it is important to introduce appropriate pharmacological and non-pharmacological treatments for HF patients. In addition, self-management of HF, including the continuation of appropriate pharmacological treatment, is also important. There have been many reports on self-management of HF. However, the effectiveness of patient education of HF is not consistent. One of the reasons may be whether the tools used are common or not. Moreover, unified systems of HF patient education and disease management in metropolitan areas are rare. We began joint HF patient education and disease management in the Tokyo southern medical district (JONAN Heart Failure Medical Collaboration: JHFeC). Patients undergo a multidisciplinary HF education program at JHFeC member hospitals to ensure that they are able to adequately record information on the self-management sheet. After discharge, the continuity of self-management will be evaluated, and further education will be provided if necessary. HF patient education is important even in severe HF requiring a left ventricular assist device, and such patient education needs to be provided appropriately in all manner of HF patients with stage A to D.</p>","PeriodicalId":15197,"journal":{"name":"Journal of Cardiovascular Development and Disease","volume":"12 3","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11942665/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143709895","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Gastrointestinal Bleeding During Long-Term Left Ventricular Assist Device Support: External Validation of UTAH Bleeding Risk Score.","authors":"Giuseppe Vadalà, Cristina Madaudo, Alessandra Fontana, Vincenzo Sucato, Gioele Bicelli, Laura Maniscalco, Antonio Luca Maria Parlati, Giovanna Panarello, Sergio Sciacca, Michele Pilato, Manlio Cipriani, Alfredo Ruggero Galassi","doi":"10.3390/jcdd12030105","DOIUrl":"10.3390/jcdd12030105","url":null,"abstract":"<p><strong>Background: </strong>Gastrointestinal bleeding (GIB) is a common complication of left ventricular assist device (LVAD) support. The UTAH bleeding risk score (UBRS) is the only dedicated GIB prediction model, but its efficacy has not been confirmed in an external validation cohort. Furthermore, the reliability of other bleeding risk scores, such as ARC-HBR and HASBLED, has never been tested in this specific population. This study aims to validate the UBRS and compare its accuracy with the ARC-HBR and HASBLED scores.</p><p><strong>Methods: </strong>Major adverse events (MAEs) and bleeding events of 75 consecutive patients who had undergone LVAD implantation between 2010 and 2021 at a referral hospital for a heart transplant were retrospectively analyzed. The accuracy of the UBRS, ARC-HBR and HASBLED scores was evaluated using a ROC curve model.</p><p><strong>Results: </strong>At a mean follow-up of 905.9 ± 724 days, 58 (77.3%) patients had an MAE and 28 (37.3%) had a major bleeding event. Out of the 39 major bleeding events, the majority were GI (43%) and intracranial bleeding (33.3%). Compared with patients without major bleeding, those who experienced major bleeding showed a lower survival probability, regardless of the nature of the bleeding (GIB vs. other bleeding events). The UBRS effectively stratified the bleeding risk with an AUC of 0.86. In contrast, the ARC-HBR and HASBLED scores demonstrated lower discriminatory power, with AUCs of 0.61 and 0.52, respectively.</p><p><strong>Conclusions: </strong>UBRS accuracy was confirmed in our study population. Gastrointestinal bleeding is a common life-threatening complication and one of the main causes of re-hospitalization during VAD support, leading to a lower patient survival probability.</p>","PeriodicalId":15197,"journal":{"name":"Journal of Cardiovascular Development and Disease","volume":"12 3","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11943341/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143709568","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Transition to Advanced Heart Failure: From Identification to Improving Prognosis.","authors":"Nikolaos-Iason Tepetes, Christos Kourek, Adamantia Papamichail, Andrew Xanthopoulos, Peggy Kostakou, Ioannis Paraskevaidis, Alexandros Briasoulis","doi":"10.3390/jcdd12030104","DOIUrl":"10.3390/jcdd12030104","url":null,"abstract":"<p><p>Advanced heart failure (AHF) represents the terminal stage of heart failure (HF), characterized by persistent symptoms and functional limitations despite optimal guideline-directed medical therapy (GDMT). This review explores the clinical definition, pathophysiology, and therapeutic approaches for AHF. Characterized by severe symptoms, New York Heart Association (NYHA) class III-IV, significant cardiac dysfunction, and frequent hospitalizations, AHF presents substantial challenges in prognosis and management. Pathophysiological mechanisms include neurohormonal activation, ventricular remodeling, and systemic inflammation, leading to reduced cardiac output and organ dysfunction. Therapeutic strategies for AHF involve a multidisciplinary approach, including pharmacological treatments, device-based interventions like ventricular assisted devices, and advanced options such as heart transplantation. Despite progress, AHF management faces limitations, including disparities in access to care and the need for personalized approaches. Novel therapies, artificial intelligence, and remote monitoring technologies offer future opportunities to improve outcomes. Palliative care, which focuses on symptom relief and quality of life, remains crucial for patients ineligible for invasive interventions. Early identification and timely intervention are pivotal for enhancing survival and functional outcomes in this vulnerable population. This review underscores the necessity of integrating innovative technologies, personalized medicine, and robust palliative strategies into AHF management to address its high morbidity and mortality.</p>","PeriodicalId":15197,"journal":{"name":"Journal of Cardiovascular Development and Disease","volume":"12 3","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11943400/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143709900","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence and Correlates of Dilated and Non-Dilated Left Ventricular Cardiomyopathy in Transfusion-Dependent Thalassemia: Data from a National, Multicenter, Observational Registry.","authors":"Antonella Meloni, Laura Pistoia, Anna Spasiano, Francesco Sorrentino, Giuseppe Messina, Michele Santodirocco, Zelia Borsellino, Valerio Cecinati, Vincenzo Positano, Gennaro Restaino, Nicolò Schicchi, Emanuele Grassedonio, Antonino Vallone, Michele Emdin, Alberto Clemente, Andrea Barison","doi":"10.3390/jcdd12030103","DOIUrl":"10.3390/jcdd12030103","url":null,"abstract":"<p><p>We investigated the prevalence, clinical characteristics, and prognostic role of dilated cardiomyopathy (DCM) and non-dilated left ventricular cardiomyopathy (NDLVC) in patients with transfusion-dependent β-thalassemia (β-TDT). We retrospectively included 415 β-TDT patients who underwent cardiovascular magnetic resonance to quantify myocardial iron overload (MIO) and biventricular function parameters and to detect replacement myocardial fibrosis. Demographic and laboratory parameters were comparable among patients with no overt cardiomyopathy (NOCM; <i>n</i> = 294), DCM (<i>n</i> = 12), and NDLVC (<i>n</i> = 109), while cardiac size and systolic function were significantly different. Compared to NOCM patients, DCM and NDLVC patients had a higher prevalence of MIO and replacement myocardial fibrosis. During a mean follow-up of 57.03 ± 18.01 months, cardiac complications occurred in 32 (7.7%) patients: 15 heart failures, 15 supraventricular arrhythmias, and 2 pulmonary hypertensions. Compared to the NOCM group, both the NDLVC and the DCM groups were associated with a significantly increased risk of cardiac complications (hazard ratio = 4.26 and 8.81, respectively). In the multivariate analysis, the independent predictive factors were age, MIO, and the presence of DCM and NDLVC versus the NOCM phenotype. In β-TDT, the detection of NDLVC and DCM phenotypes may hold value in predicting cardiac outcomes.</p>","PeriodicalId":15197,"journal":{"name":"Journal of Cardiovascular Development and Disease","volume":"12 3","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-03-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11943376/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143709877","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Does Long-Term Sport Practice Facilitate the Development of Idiopathic Bradycardia Requiring Early Pacemaker Implantation During the Course of Life?","authors":"Sergei Bondarev, Leonardo Brotto, Francesca Graziano, Alberto Cipriani, Domenico Corrado, Alessandro Zorzi","doi":"10.3390/jcdd12030102","DOIUrl":"10.3390/jcdd12030102","url":null,"abstract":"<p><p><i>Background</i>: Sinus bradycardia and first-/second-degree atrioventricular (AV) block in athletes are traditionally considered secondary to increased vagal tone and therefore reversible. However, recent studies have suggested that they may persist even after the cessation of physical activity, and combined with the effects of aging, lead to the earlier onset of clinically significant bradyarrhythmias. <i>Methods:</i> We evaluated the correlation between lifetime sport practice and the age of the onset of premature (≤70 years old) idiopathic sinoatrial node or AV node dysfunction requiring pacemaker (PM) implantation. <i>Results</i>: Of the 1316 patients followed up with at our PM clinic in 2024, we included 79 (6%) who received a PM when they were ≤70 years old for bradyarrhythmias in the absence of secondary causes. Nineteen (24%) had engaged in at least 6 h of sports/week for ≥20 years and were classified as former athletes. For comparison, former athletes who received a PM for idiopathic bradycardia at >70 years old were 6% (<i>p</i> < 0.001). In the group ≤70 years old, the average age of PM implantation was 62.8 years in non-athletes versus 57.9 years in former athletes (<i>p</i> = 0.03). The main reason for PM implantation was AV block in both subgroups. Among former athletes, the correlation between the lifetime volume of sports activity and the age of PM implantation reached borderline statistical significance (<i>p</i> = 0.08). Echocardiography at the time of implant did not reveal significant differences between former athletes and non-athletes. <i>Conclusions:</i> In a cohort of patients who received a PM for bradyarrhythmia before the age of 70 years old in the absence of secondary causes, former athletes were implanted on average ≈5 years before non-athletes. This may suggest a contributing role of cumulative sports activity volume in the development of idiopathic sinus/AV node dysfunction.</p>","PeriodicalId":15197,"journal":{"name":"Journal of Cardiovascular Development and Disease","volume":"12 3","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11942681/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143709942","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}