Journal of Cardiovascular Development and Disease最新文献

{"title":"Time-Dependent ECG-AI Prediction of Fatal Coronary Heart Disease: A Retrospective Study.","authors":"Liam Butler, Alexander Ivanov, Turgay Celik, Ibrahim Karabayir, Lokesh Chinthala, Mohammad S Tootooni, Byron C Jaeger, Luke T Patterson, Adam J Doerr, David D McManus, Robert L Davis, David Herrington, Oguz Akbilgic","doi":"10.3390/jcdd11120395","DOIUrl":"10.3390/jcdd11120395","url":null,"abstract":"<p><p><b>Background</b>: Fatal coronary heart disease (FCHD) affects ~650,000 people yearly in the US. Electrocardiographic artificial intelligence (ECG-AI) models can predict adverse coronary events, yet their application to FCHD is understudied. <b>Objectives</b>: The study aimed to develop ECG-AI models predicting FCHD risk from ECGs. <b>Methods (Retrospective)</b>: Data from 10 s 12-lead ECGs and demographic/clinical data from University of Tennessee Health Science Center (UTHSC) were used for model development. Of this dataset, 80% was used for training and 20% as holdout. Data from Atrium Health Wake Forest Baptist (AHWFB) were used for external validation. We developed two separate convolutional neural network models using 12-lead and Lead I ECGs as inputs, and time-dependent Cox proportional hazard models using demographic/clinical data with ECG-AI outputs. Correlation of the predictions from the 12- and 1-lead ECG-AI models was assessed. <b>Results</b>: The UTHSC cohort included data from 50,132 patients with a mean age (SD) of 62.50 (14.80) years, of whom 53.4% were males and 48.5% African American. The AHWFB cohort included data from 2305 patients with a mean age (SD) of 63.04 (16.89) years, of whom 51.0% were males and 18.8% African American. The 12-lead and Lead I ECG-AI models resulted in validation AUCs of 0.84 and 0.85, respectively. The best overall model was the Cox model using simple demographics with Lead I ECG-AI output (D1-ECG-AI-Cox), with the following results: AUC = 0.87 (0.85-0.89), accuracy = 83%, sensitivity = 69%, specificity = 89%, negative predicted value (NPV) = 92% and positive predicted value (PPV) = 55% on the AHWFB validation cohort. For this, the 2-year FCHD risk prediction accuracy was AUC = 0.91 (0.90-0.92). The 12-lead versus Lead I ECG FCHD risk prediction showed strong correlation (R = 0.74). <b>Conclusions</b>: The 2-year FCHD risk can be predicted with high accuracy from single-lead ECGs, further improving when combined with demographic information.</p>","PeriodicalId":15197,"journal":{"name":"Journal of Cardiovascular Development and Disease","volume":"11 12","pages":""},"PeriodicalIF":2.4,"publicationDate":"2024-12-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11678222/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142894709","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Introduction of a New Mobile Driving Unit for a Ventricular Assist Device in a Pediatric Patient (EXCOR Active).","authors":"Nuri Ünesen, Christian Balmer, Martin Schweiger","doi":"10.3390/jcdd11120392","DOIUrl":"10.3390/jcdd11120392","url":null,"abstract":"<p><p>Pediatric patients supported by extracorporeal ventricular assist devices traditionally require long-term stationary inpatient settings. Limited mobility and permanent hospitalization significantly reduce their quality of life. Berlin Heart address this with their novel mobile driving unit, EXCOR^® Active. This case report presents its first application outside of Germany, where it was developed, focusing on staff education and safety measures leading to a successful switch of driving units.</p>","PeriodicalId":15197,"journal":{"name":"Journal of Cardiovascular Development and Disease","volume":"11 12","pages":""},"PeriodicalIF":2.4,"publicationDate":"2024-12-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11677815/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142894705","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Percutaneous Embolization of No Ligated Vertical Veins After Total Anomalous Pulmonary Vein Return Operation and Risk Factors for Its Persistence.","authors":"Stasa Krasic, Sofija Popovic, Vesna Topic, Mila Stajevic, Ivan Dizdarevic, Sasa Popovic, Dejan Nesic, Vladislav Vukomanovic","doi":"10.3390/jcdd11120393","DOIUrl":"10.3390/jcdd11120393","url":null,"abstract":"<p><strong>Background: </strong>The vertical vein (VV) ligation during the total anomalous pulmonary venous return (TAPVR) correction is still controversial. Our study aimed to define the potential risk factors for VV persistence and their percutaneous occlusion.</p><p><strong>Methods: </strong>The retrospective cohort study included 40 patients (26 males) with TAPVR treated at the tertiary referral center from 2005 to 2024.</p><p><strong>Results: </strong>The average days of age at diagnosis was two (IQR 1-8). Complex congenital heart disease with TAPVR was diagnosed in eight patients. A supracardiac type of TAPVR was found in 47% of them. The patients underwent the operation on their eighth day of life (IQR 5-57). The follow-up period was 32 months (IQR 8-99). The early postoperative mortality rate was 17.5%, significantly frequent in the patients' group with combined CHD (<i>p</i> = 0.002). Four were reoperated on-three due to a postoperative obstruction between the pulmonary venous confluence and the left atrium (LA), while in one patient, a redirection of the VCI was performed. Four patients, aged 12.3 on average (IQR 8.9-14.7), underwent vertical vein embolization. All patients achieved complete occlusion with AVP2. The LA diameter Z score was lower than -4, an increased risk for VV persistence of almost 19 times (OR 18.6, 95% CI 1.6-216.0).</p><p><strong>Conclusions: </strong>We found that an LA diameter Z score of lower than -4 was a major risk factor for VV persistence. Percutaneous VV embolization is a safe and effective procedure in adolescents.</p>","PeriodicalId":15197,"journal":{"name":"Journal of Cardiovascular Development and Disease","volume":"11 12","pages":""},"PeriodicalIF":2.4,"publicationDate":"2024-12-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11676295/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142894648","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Emotional Distress and Cardiovascular Health in Young Adults with Type 1 Diabetes.","authors":"Bethany L Armentrout, Bootan H Ahmed, Sineenat Waraphok, Johnathan Huynh, Stephanie Griggs","doi":"10.3390/jcdd11120391","DOIUrl":"10.3390/jcdd11120391","url":null,"abstract":"<p><p>Type 1 diabetes (T1D) is a complex chronic condition that places young adults aged 18-31 years at high risk for general and diabetes-related distress and poor cardiovascular health. Both general and diabetes distress are linked to higher A1C, a known risk factor for cardiovascular disease (CVD). The purpose of this cross-sectional quantitative descriptive study was to examine the associations between distress symptoms (general and diabetes) and cardiovascular health while considering covariates in young adults ages 18-31 years with T1D. One-hundred and sixty-five young adults with T1D, recruited from specialty clinics through two major health systems and online platforms, completed a demographic and clinical survey along with the 8-item PROMIS Emotional Distress Scale and 17-item Diabetes Distress Scale. Higher diabetes distress and higher general emotional distress were associated with lower cardiovascular health scores. Associations remained statistically significant after adjusting for age, T1D duration, sex at birth, race, and continuous subcutaneous insulin infusion. In young adults with type 1 diabetes, addressing both diabetes and general emotional distress may be important to improve cardiovascular health. However, longitudinal and experimental studies are needed to clarify underlying mechanisms and evaluate the effectiveness of interventions like cognitive behavioral therapy.</p>","PeriodicalId":15197,"journal":{"name":"Journal of Cardiovascular Development and Disease","volume":"11 12","pages":""},"PeriodicalIF":2.4,"publicationDate":"2024-12-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11676757/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142893697","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"International Cardiovascular Development, Anatomy, and Regeneration (ICDAR) Community Meeting: Prague 2024.","authors":"David Sedmera, Antonio Baldini, Maurice van den Hoff, Bill Chaudhry","doi":"10.3390/jcdd11120390","DOIUrl":"10.3390/jcdd11120390","url":null,"abstract":"<p><p>The International Cardiovascular Anatomy, Development, and Regeneration meeting was held from 18-20 September 2024, in Prague, Czech Republic, supported by the European Society of Cardiology's Working Group on Development, Anatomy, and Pathology. Hosted at the Institute of Anatomy, First Faculty of Medicine, the event began with a hands-on workshop on normal and malformed human hearts, covering morphology, echocardiographic imaging, and rare congenital cases. The session allowed participants to examine and image both normal and malformed hearts. The main conference featured nine platform sessions on topics including pediatric cardiology, cardiac progenitors biology, congenital heart disease mechanisms, and cardiac regeneration. Highlights included two keynote lectures on cardiac genetics and development. In keeping with an established, decades-long tradition, the conference is a well-attended event, marking significant engagement in the latest cardiovascular research. The next appointment will be in Granada, Spain, 15-17 October 2025.</p>","PeriodicalId":15197,"journal":{"name":"Journal of Cardiovascular Development and Disease","volume":"11 12","pages":""},"PeriodicalIF":2.4,"publicationDate":"2024-12-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11678715/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142894623","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prognostic Value of Strain by Speckle Tracking Echocardiography in Patients with Arrhythmogenic Right Ventricular Cardiomyopathy.","authors":"Areej Aljehani, Kyaw Zaw Win, Shanat Baig, Manish Kalla, Bode Ensam, Larissa Fabritz, Richard P Steeds","doi":"10.3390/jcdd11120388","DOIUrl":"10.3390/jcdd11120388","url":null,"abstract":"<p><p>Background Arrhythmogenic right ventricular cardiomyopathy (ARVC) is a rare genetic disorder associated with an elevated risk of life-threatening arrhythmias and progressive ventricular impairment. Risk stratification is essential to prevent major adverse cardiac events (MACE). Our study aimed to investigate the incremental value of strain measured by two-dimensional speckle-tracking echocardiography in predicting MACE in ARVC patients compared to conventional echocardiographic parameters. Methods and Results This was a retrospective, single-centre cohort study of 83 patients with ARVC (51% males, median age 37 years (IQR: 23, 53)) under the care of the Inherited Cardiac Conditions clinic at University Hospital Birmingham. MACE was defined as one of the following: sustained ventricular tachycardia (Sus VT), ventricular fibrillation (VF), appropriate implantable cardio-defibrillator (ICD) therapy [shock/anti-tachycardia pacing (ATP)], heart failure (defined as decompensated heart failure, cardiac index by heart catheter, HF medication, and symptoms), cardiac transplantation, or cardiac death. Echocardiography images were analysed by a single observer for right ventricle (RV) and left ventricular (LV) global longitudinal strain (GLS). Multivariable Cox regression was performed in combination with RV fractional area change and tricuspid annular plane systolic excursion. During three years of follow-up, 12% of patients suffered a MACE. ARVC patients with MACE had significantly reduced RV GLS (-13 ± 6% vs. -23 ± 6%, <i>p</i> < 0.001) and RV free wall longitudinal strain (-15 ± 5% vs. -25 ± 7%, <i>p</i> < 0.001) compared to those without MACE. Conclusions Right ventricular free wall longitudinal strain (RVFWLS) may be a more sensitive predictor of MACE than conventional echocardiographic parameters of RV function. Moreover, RV-free wall longitudinal strain may have superior predictive value compared to RV GLS.</p>","PeriodicalId":15197,"journal":{"name":"Journal of Cardiovascular Development and Disease","volume":"11 12","pages":""},"PeriodicalIF":2.4,"publicationDate":"2024-12-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11678278/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142894671","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of the Efficacy and Accuracy of Super-Flexible Three-Dimensional Heart Models of Congenital Heart Disease Made via Stereolithography Printing and Vacuum Casting: A Multicenter Clinical Trial.","authors":"Isao Shiraishi, Masaaki Yamagishi, Takaya Hoashi, Yoshiaki Kato, Shigemitsu Iwai, Hajime Ichikawa, Tatsuya Nishii, Hiroyuki Yamagishi, Satoshi Yasukochi, Masaaki Kawada, Takaaki Suzuki, Takeshi Shinkawa, Naoki Yoshimura, Ryo Inuzuka, Yasutaka Hirata, Keiichi Hirose, Akio Ikai, Kisaburo Sakamoto, Yasuhiro Kotani, Shingo Kasahara, Toshiaki Hisada, Kenichi Kurosaki","doi":"10.3390/jcdd11120387","DOIUrl":"10.3390/jcdd11120387","url":null,"abstract":"<p><p>Three-dimensional (3D) printing is an advanced technology for accurately understanding anatomy and supporting the successful surgical management of complex congenital heart disease (CHD). We aimed to evaluate whether our super-flexible 3D heart models could facilitate preoperative decision-making and surgical simulation for complex CHD. The super-flexible heart models were fabricated by stereolithography 3D printing of the internal and external contours of the heart from cardiac computed tomography (CT) data, followed by vacuum casting with a polyurethane material similar in elasticity to a child's heart. Nineteen pediatric patients with complex CHD were enrolled (median age, 10 months). The primary endpoint was defined as the percentage of patients rated as \"essential\" on the surgeons' postoperative 5-point Likert scale. The accuracy of the models was validated by a non-destructive method using industrial CT. The super-flexible heart models allowed detailed anatomical diagnosis and simulated surgery with incisions and sutures. Thirteen patients (68.4%) were classified as \"essential\" by the primary surgeons after surgery, with a 95% confidence interval of 43.4-87.4%, meeting the primary endpoint. The product error within 90% of the total external and internal surfaces was 0.54 ± 0.21 mm. The super-flexible 3D heart models are accurate, reliable, and useful tools to assist surgeons in decision-making and allow for preoperative simulation in CHD.</p>","PeriodicalId":15197,"journal":{"name":"Journal of Cardiovascular Development and Disease","volume":"11 12","pages":""},"PeriodicalIF":2.4,"publicationDate":"2024-12-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11677195/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142894635","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Retrospective Study on Short-Term Reverse Cardiac Remodeling in Obese Patients Undergoing Sleeve Gastrectomy.","authors":"Carmine Izzo, Valeria Visco, Alessandra Cirillo, Davide Bonadies, Giuseppe Caliendo, Maria Rosaria Rusciano, Nicola Virtuoso, Francesco Loria, Alessia Bramanti, Eleonora Venturini, Paola Di Pietro, Vincenzo Pilone, Luigi Schiavo, Albino Carrizzo, Carmine Vecchione, Michele Ciccarelli","doi":"10.3390/jcdd11120389","DOIUrl":"10.3390/jcdd11120389","url":null,"abstract":"<p><p>Severe obesity is closely associated with an increased risk of comorbidities and alterations in cardiac structure and function. The primary objective of this study was to investigate cardiovascular (CV) risk factors and ventricular remodeling in individuals from an obese population eligible for bariatric surgery. The secondary objective was to evaluate changes in anthropometric, clinical laboratory, and echocardiographic measurements 12 weeks after surgery compared to baseline values. This retrospective observational cohort study involved patients from a single specialized bariatric surgery center. A total of 35 patients were included (mean age 41.5 ± 10.3 years; BMI 43.4 ± 6.6 kg/m²), of whom 34.2% had a family history of coronary artery disease (CAD), 5.7% had a prior history of CAD, 8 had essential hypertension, 11.4% had dyslipidemia, 20% were smokers, and 8.6% were former smokers. Approximately 57% of the patients exhibited concentric left ventricular remodeling, and 14% had grade I diastolic dysfunction. At 12 weeks post-surgery, with an average weight loss of 25 kg and a mean BMI reduction of 8.5 kg/m², 14% of the patients still exhibited concentric left ventricular remodeling, and about 11% had grade I diastolic dysfunction. Bariatric surgery contributes to the improvement of cardiac function and structure over time as a result of significant weight loss.</p>","PeriodicalId":15197,"journal":{"name":"Journal of Cardiovascular Development and Disease","volume":"11 12","pages":""},"PeriodicalIF":2.4,"publicationDate":"2024-12-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11676178/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142894712","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Arrhythmia Detection in Atrioventricular, Single-Lead, Floating Atrial Dipole ICD Systems Compared with Conventional Single- and Dual-Chamber Defibrillators.","authors":"Flora Diana Gausz, Kom Nangob Manuela Lena, Paul Emmanuel Gedeon, Marton Miklos, Attila Benak, Gabor Bencsik, Attila Makai, Dora Kranyak, Rita Beata Gagyi, Robert Pap, Laszlo Saghy, Tamas Szili-Torok, Mate Vamos","doi":"10.3390/jcdd11120386","DOIUrl":"10.3390/jcdd11120386","url":null,"abstract":"<p><strong>Background: </strong>An atrioventricular defibrillator system with a floating atrial dipole (VDD ICD) can provide atrial sensing by a single lead. Our aim was to compare the arrhythmia detection efficacy of VDD ICDs with conventional single- (VVI) and dual-chamber (DDD) defibrillators.</p><p><strong>Methods: </strong>Data from consecutive patients undergoing ICD implantation were retrospectively analyzed. The primary endpoint was the incidence of device-detected, new-onset atrial arrhythmias, while secondary endpoints were sensing parameters, complication rates, incidence of appropriate/inappropriate ICD therapy, arrhythmic/heart failure-related hospitalizations, and all-cause mortality.</p><p><strong>Results: </strong>A total of 256 patients (mean age 64 ± 12 years, male 75%, primary prophylaxis 28%, mean follow-up 3.7 ± 2.4 years) were included (VVI: 93, VDD: 94, DDD: 69). Atrial arrhythmia episodes were detected more frequently by VDD systems compared to VVI ICDs (aHR 7.087; 95% CI 2.371-21.183; <i>p</i> < 0.001), and at a rate similar to that of DDD ICDs (aHR 1.781; 95% CI 0.737-4.301; <i>p</i> = 0.200). The rate of inappropriate shocks was not different among the three ICD systems.</p><p><strong>Conclusion: </strong>VDD devices revealed an advantage in atrial arrhythmia detection compared to VVI ICDs and were non-inferior to DDD systems. Their main indication may be closer monitoring in high-risk patients with atrial arrhythmias to help therapy optimization and not the improvement of tachycardia discrimination.</p>","PeriodicalId":15197,"journal":{"name":"Journal of Cardiovascular Development and Disease","volume":"11 12","pages":""},"PeriodicalIF":2.4,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11677019/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142894799","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Long-Term Patient-Reported Outcomes After Radiofrequency Ablation and Cryoballoon Ablation for Paroxysmal Atrial Fibrillation: The Effect of Additional Ablations.","authors":"Ibrahim Antoun, Ahmed I Kotb, Zakkariya Vali, Ahmed Abdelrazik, Ivelin Koev, Kassem Safwan, Edward Y M Lau, Riyaz Somani, Ghulam André Ng","doi":"10.3390/jcdd11120385","DOIUrl":"10.3390/jcdd11120385","url":null,"abstract":"<p><strong>Background: </strong>pulmonary vein isolation (PVI) for paroxysmal atrial fibrillation (PAF) improves health-related quality of life (QoL). This study compares QoL improvement after radiofrequency ablation (RF) and cryoballoon ablation (cryo) and assesses additional ablations' role in QoL improvement.</p><p><strong>Methods: </strong>we evaluated the QoL of consecutive patients with first-time RF and cryo for PAF between January 2017 and June 2019. A combined EQ-VAS, AFEQT, and EQ-5D-3L paper questionnaire was sent to patients at baseline, 12, and 30 months after the procedure. Procedure and patient details were collected from medical notes.</p><p><strong>Results: </strong>the analysis included 207 patients, of which 127 (61%) had RF and 144 (70%) were males. RF patients had more additional ablations (52 [41%] versus 22 [28%], <i>p</i> = 0.01). There was a significant improvement from baseline to 12 months post-RF in AFEQT (43 ± 9 to 83 ± 7.8, <i>p</i> < 0.001), EQ-5D-3L (-0.01 ± 0.01 to 1.1 ± 0.02, <i>p</i> < 0.001), and EQ-VAS (51 ± 8 to 77 ± 13, <i>p</i> = 0.01). Similarly, an improvement at 12 months was observed after cryo in AFEQT (55 ± 11 to 77 ± 9, <i>p</i> < 0.001), EQ-5D-3L (-0.04 ± 0.03 to 1.3 ± 0.03, <i>p</i> < 0.001), and EQ-VAS (56 ± 7 to 85 ± 9, <i>p</i> = 0.01). QoL improvement was similar between RF and cryo. Additional ablations provided no additional QoL improvement compared to patients with PVI alone.</p><p><strong>Conclusions: </strong>Patients undergoing first-time PVI for PAF, RF, and cryo showed similar QoL improvement at 12 months, which was sustained at 30 months. Additional ablations did not provide further QoL benefits.</p>","PeriodicalId":15197,"journal":{"name":"Journal of Cardiovascular Development and Disease","volume":"11 12","pages":""},"PeriodicalIF":2.4,"publicationDate":"2024-11-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11676108/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142894643","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}