Journal of Cardiovascular Development and Disease最新文献

{"title":"Intraoperative Hemoadsorption in Heart Transplant Surgery: A 5-Year Experience.","authors":"Nikola Sliskovic, Gloria Sestan, Savica Gjorgjievska, Davor Baric, Daniel Unic, Josip Varvodic, Marko Kusurin, Dubravka Susnjar, Sarah Singer, Igor Rudez","doi":"10.3390/jcdd12040119","DOIUrl":"https://doi.org/10.3390/jcdd12040119","url":null,"abstract":"<p><strong>Background: </strong>Hyperimmune response and cytokine release post-reperfusion might occur after orthotopic heart transplantation (HTx). Intraoperative hemoadsorption (HA) has been introduced to remove such elevated cytokines. We aimed to analyze the effect of intraoperative HA in patients undergoing orthotopic HTx.</p><p><strong>Methods: </strong>Between 2018 and 2022, 40 consecutive orthotopic HTx patients who underwent intraoperative hemoadsorption HA integrated into the cardiopulmonary bypass were compared to 41 historical controls. Primary outcome measures included postoperative hemodynamic stability and blood product requirements, while secondary outcomes were the incidence of acute kidney injury requiring dialysis (AKI-d) and 30-day mortality.</p><p><strong>Results: </strong>Postoperatively, the vasoactive-inotropic score (VIS) did not significantly differ between the groups. However, the use duration for milrinone and dobutamine was shortened by one day compared to controls. The HA group had fewer red blood cell transfusions (765 vs. 1330 mL, <i>p</i> = 0.01) and lower fresh frozen plasma requirements (945 vs. 1200 mL, <i>p</i> = 0.04). Mechanical ventilation duration was reduced (22 vs. 28 h, <i>p</i> = 0.02). AKI-d rates were similar, and 30-day mortality favored non-significantly the HA group (5% vs. 14.6%, <i>p</i> = ns). No device-related adverse events were observed.</p><p><strong>Conclusion: </strong>These findings suggest that intraoperative HA might improve immediate postoperative outcomes; however, further validation in larger randomized controlled trials is warranted.</p>","PeriodicalId":15197,"journal":{"name":"Journal of Cardiovascular Development and Disease","volume":"12 4","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12028209/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144012652","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dilated Cardiomyopathy: A Novel <i>BAG3</i> Mutation Associated with Aggressive Disease Progression and Ventricular Arrhythmias.","authors":"Paolo Pastori, Cristina Balla, Marta Rasia, Emilia Lo Jacono, Clelia Guerra, Roberta Schininà, Francesca Gualandi, Matteo Bertini, Giovanni Tortorella","doi":"10.3390/jcdd12040121","DOIUrl":"https://doi.org/10.3390/jcdd12040121","url":null,"abstract":"<p><p>We present the case of a 46-year-old man with a history of complex ventricular arrhythmias preceding the development of asymptomatic mild left ventricular dysfunction, who presented with acute-onset heart failure and was ultimately diagnosed with dilated cardiomyopathy. Genetic testing identified a novel, likely pathogenic mutation in exon 4 of the <i>BAG3</i> gene (NM_004281, c.1128del, (p.(Ser377AlafsTer47)), not previously reported in the literature. Given the presence of multiple clinical features indicative of a poor prognosis, he underwent prophylactic placement of a subcutaneous implantable cardioverter-defibrillator. The clinical presentation of this novel <i>BAG3</i> mutation suggests that it may be associated with a significant arrhythmic phenotype. This case underscores the importance of close follow-up and genetic testing in patients presenting with mild left ventricular dysfunction and ventricular arrhythmias.</p>","PeriodicalId":15197,"journal":{"name":"Journal of Cardiovascular Development and Disease","volume":"12 4","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12027914/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143965698","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bradycardias in Patients with Pulmonary Hypertension-Prevalence, Pathophysiology and Clinical Relevance.","authors":"Paul Ole Behrendt, Lukas Ley, Hossein Ardeschir Ghofrani, Dirk Bandorski","doi":"10.3390/jcdd12040120","DOIUrl":"https://doi.org/10.3390/jcdd12040120","url":null,"abstract":"<p><strong>Introduction: </strong>Arrhythmias are a frequent complication of pulmonary hypertension (PH). Supraventricular tachycardias (SVT) are predominantly reported and are associated with clinical deterioration and an increased mortality. In contrast, the prevalence and clinical relevance of bradycardias is largely unclear. Therefore, the aim of the present study was to determine a prevalence of bradycardias in PH patients and to outline their clinical relevance.</p><p><strong>Material and methods: </strong>Between January 2000 and June 2013, consecutive PH patients were pro- and retrospectively enrolled in two cohorts. Patients received either a 24 h or 72 h Holter ECG.</p><p><strong>Results: </strong>A total of 314 patients (58% female, mean age: 63 years) from PH groups 1-5 (39%, 11%, 19%, 28%, 3%) were included. Basic heart rhythm was sinus rhythm in 87% of patients (9% atrial fibrillation, 2% atrial flutter and 2% paced rhythm). Further arrhythmias were detected in 34% of patients (SVT: 12%, non-sustained ventricular tachycardia: 16%) with a 6% prevalence of relevant bradycardias. Atrioventricular block was revealed in 5% of patients (seven first-degree, one and three second-degree Wenckebach and Mobitz type, respectively, four third-degree), and 1% revealed sinoatrial block (one second-degree, third-degree and unspecified each).</p><p><strong>Conclusions: </strong>The prevalence of bradycardias appears to be about 5-10% in PH patients. Most of them are short and self-limiting. However, some patients experience syncope or clinical deterioration and, therefore, need specific treatment. To find these patients, long-term ECG monitoring combined with ECG-symptom correlation may be useful. Bradycardic medication should be excluded as a cause.</p>","PeriodicalId":15197,"journal":{"name":"Journal of Cardiovascular Development and Disease","volume":"12 4","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12027764/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144016224","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of 30-Day Readmission Between Early and Late Catheter Directed Thrombolysis for Acute Pulmonary Embolism in the United States.","authors":"Kwabena Sefah Nketiah Sarpong, Sun-Joo Jang, Mary Quien, Karthik Muralidharan, Abhinav Aggarwal, Ilhwan Yeo, Kavitha Gopalratnam","doi":"10.3390/jcdd12040118","DOIUrl":"https://doi.org/10.3390/jcdd12040118","url":null,"abstract":"<p><strong>Background: </strong>Pulmonary embolism (PE) is a major cause of morbidity and mortality accounting for 100,000 deaths per year in the United States and 5-10% of in-hospital deaths. There is sparse comparative data on readmission patterns in patients who undergo early versus late catheter directed thrombolysis (CDT) for acute PE.</p><p><strong>Research question: </strong>Is the procedure day for acute PE associated with a difference in 30-day readmission rates?</p><p><strong>Study design and method: </strong>This study was performed by using the Nationwide Readmissions Database between 2016 and 2019. Patients with acute PE who underwent CDT were identified using codes from the International Classification of Diseases, 10th Edition (ICD 10).</p><p><strong>Results: </strong>The 30-day readmission rates were higher for patients who underwent CDT on Day 2 or afterwards compared to Day 1 and Day 0 (7.1% vs. 5.7% vs. 5.2%). Patients who had CDT on Day 2 or later had a higher rate of 30-day readmission mortality compared to those who had CDT on Day 1 or 0 (0.6% vs. 0.3% vs. 0.2%. The 30-day readmission rates for heart failure were higher among patients who had CDT on Day 2 compared to those who had CDT on Day 0 of admission (2% vs. 1.0% vs. 0.9%).</p><p><strong>Interpretation: </strong>Delayed CDT for acute PE was associated with increased rates of 30-day readmission, readmission mortality, and readmission for heart failure. These findings emphasize the need for earlier CDT for the treatment of acute PE.</p>","PeriodicalId":15197,"journal":{"name":"Journal of Cardiovascular Development and Disease","volume":"12 4","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12027995/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143970556","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of Revascularization on Major Adverse Cardiovascular Events in Patients Without ST-Elevation Myocardial Infarction in the Arabian Gulf.","authors":"Ibrahim Al-Zakwani, Fahad AlKindi, Wael Almahmeed, Mohammad Zubaid","doi":"10.3390/jcdd12040117","DOIUrl":"https://doi.org/10.3390/jcdd12040117","url":null,"abstract":"<p><p><b>Objectives</b>: The study evaluated the impact of revascularization procedures, including percutaneous coronary intervention (PCI) and coronary artery bypass graft (CABG), during the index hospitalization on major adverse cardiovascular events (MACE) in patients with non-ST-elevation myocardial infarction (NSTEMI) in the Arabian Gulf. <b>Methods</b>: Data were analyzed from 1820 consecutive patients diagnosed with NSTEMI, admitted to 29 hospitals in four Arabian Gulf countries from January 2012 to January 2013, and who were discharged alive. <b>Results</b>: Of the patients, 29.1% (n = 529) underwent either PCI (89.8%; n = 475) or CABG (10.2%; n = 54). The matching method (288 PCI/CABG patients were matched with 762 controls that did not undergo PCI/CABG) revealed significant reductions in MACE events among patients who had undergone PCI/CABG (25% vs. 43%; <i>p</i> < 0.001). This decrease was consistent across individual MACE components, including stroke/transient ischemic attack (TIA) (2.4% vs. 7.0%; <i>p</i> = 0.005), all-cause mortality (4.5% vs. 7.0%; <i>p</i> < 0.001) and cardiac-related readmissions (20% vs. 31%; <i>p</i> = 0.001) but not reinfarction (1.7% vs. 1.4%; <i>p</i> = 0.73). <b>Conclusions</b>: The revascularization procedures, PCI/CABG, were associated with significant reductions in annual MACE event rates, specifically lower stroke/TIA, all-cause mortality and cardiac-related readmissions.</p>","PeriodicalId":15197,"journal":{"name":"Journal of Cardiovascular Development and Disease","volume":"12 4","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12028046/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144036309","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Readmissions for Cardiac Disease Within 30 Days of Hospitalization for Cerebral Infarction: An Evaluation of the Stroke-Heart Syndrome Using the Nationwide Readmission Database.","authors":"Chun Shing Kwok, Adnan I Qureshi, Josip Andelo Borovac, Maximilian Will, Konstantin Schwarz, Mark Hall, Paul Mann, Eric Holroyd, Gregory Y H Lip","doi":"10.3390/jcdd12040116","DOIUrl":"https://doi.org/10.3390/jcdd12040116","url":null,"abstract":"<p><strong>Background: </strong>The stroke-heart syndrome refers to incident cardiac complications post stroke. This study aims to evaluate the stroke-heart syndrome by determining the rate and predictors of readmission for cardiac disease within 30 days of hospitalization for cerebral infarction.</p><p><strong>Methods: </strong>Data from the United States Nationwide Readmissions Database (2018 to 2020) were analyzed to identify rates and factors associated with 30-day readmissions for heart disease following cerebral infarction, excluding patients with atrial fibrillation, heart failure and myocardial infarction during admission with cerebral infarction.</p><p><strong>Results: </strong>There were 3,115,850 hospital admissions for cerebral infarction, and 75,440 admissions (2.4%) were readmitted with new onset cardiac events within 30 days of discharge. This included 36,310 (1.4%) readmissions for heart failure, 35,900 (1.1%) readmissions for atrial fibrillation, 17,465 (0.5%) readmissions for acute myocardial infarction, 810 (0.03%) readmissions for ventricular arrhythmias and 700 (0.02%) readmissions for Takotsubo syndrome. Readmitted patients were older (median age of 73 years vs. 68 years, <i>p</i> < 0.001) and had a longer length of stay for initial admission (median of 4 days vs. 3 days, <i>p</i> < 0.001). The most significant predictors of readmission were elective admission (OR 2.00, 95%CI 1.89-2.13, <i>p</i> < 0.001), cancer (OR 1.91, 95%CI 1.81-2.01, <i>p</i> < 0.001), chronic kidney disease (OR 1.80, 95%CI 1.73-1.87, <i>p</i> < 0.001), previous myocardial infarction (OR 1.59, 95%CI 1.50-1.69, <i>p</i> < 0.001) and liver failure (OR 1.34, 95%CI 1.06-1.68, <i>p</i> = 0.013). Palliative care was linked to a reduced odds of readmission (OR 0.36, 95%CI 0.31-0.41, <i>p</i> < 0.001).</p><p><strong>Conclusions: </strong>New cardiac-related hospital readmissions within 30 days after ischemic stroke occur in 2.4% of patients, with elective admission and cancer being a strong predictor of readmissions.</p>","PeriodicalId":15197,"journal":{"name":"Journal of Cardiovascular Development and Disease","volume":"12 4","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12027694/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144003113","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Global Analysis of Nutritional Factors and Cardiovascular Risk: Insights from Worldwide Data and a Case Study in Mexican Children.","authors":"Karmina Sánchez-Meza, Gustavo A Hernández-Fuentes, Estibaliz Sánchez-Meza, Ivan Delgado-Enciso, Carmen A Sánchez-Ramírez, Roberto Muñiz-Valencia, José Guzmán-Esquivel, Idalia Garza-Veloz, Margarita L Martinez-Fierro, Iram P Rodriguez-Sanchez, Janet Diaz-Martinez, Joel Cerna-Cortés, Oscar F Beas-Guzmán, Mario Ramírez-Flores","doi":"10.3390/jcdd12040115","DOIUrl":"https://doi.org/10.3390/jcdd12040115","url":null,"abstract":"<p><p>Cardiovascular diseases (CVDs) are the leading cause of mortality worldwide, with growing concerns about the impact of omega-6 polyunsaturated fatty acids (n-6 PUFAs) on cardiovascular health. This study aims to evaluate the relationship between serum linoleic acid (LA) levels and waist-to-height ratio (WHtR), a recognized cardiovascular risk marker, in children. The research was conducted in two parts. First, a global analysis of publicly available data (2019-2021) explored the association between nutritional factors and CVD prevalence across 183 countries. Second, a cross-sectional study involving 67 children (33 with obesity and 34 with healthy weight, classified using BMI Z-scores) examined the correlation between serum LA levels and WHtR. Global analysis revealed a moderate correlation between low seafood omega-3 fatty acid intake and CVD incidence (rho = 0.341), while low polyunsaturated fatty acid consumption showed a weak correlation (rho = 0.228). In children, a significant positive correlation was observed between serum LA levels and WHtR (rho = 0.716, <i>p</i> < 0.001), with similar correlations found when stratified by sex (girls: rho = 0.690; boys: rho = 0.709). Serum LA levels also correlated positively with weight (rho = 0.684). These findings are consistent with the existing literature, that high serum LA levels may contribute to early cardiometabolic risk in children, emphasizing the need for dietary interventions to mitigate cardiovascular risks in early life.</p>","PeriodicalId":15197,"journal":{"name":"Journal of Cardiovascular Development and Disease","volume":"12 4","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12027729/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144025959","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Role of Cardiac Magnetic Resonance in Characterizing Atrial Cardiomyopathy and Guiding Substrate Ablation in Atrial Fibrillation: A Narrative Review.","authors":"Jean Pierre Jabbour, Marta Palombi, Michela Bonanni, Andrea Matteucci, Luca Arcari, Nicola Pierucci, Vincenzo Mirco La Fazia, Carlo Lavalle, Marco Valerio Mariani","doi":"10.3390/jcdd12040114","DOIUrl":"https://doi.org/10.3390/jcdd12040114","url":null,"abstract":"<p><p>Cardiac magnetic resonance imaging (MRI) is increasingly recognized as a promising tool for tissue characterization in atrial fibrillation (AF), providing detailed insights into anatomy, fibrosis, and scarring. While MRI cannot directly guide ablation lesions, its ability to identify arrhythmogenic substrates could improve patient stratification and procedural planning. Despite these theoretical advantages, the clinical utility of MRI in guiding substrate-based ablation strategies remains a matter of debate. Methods: Our review evaluates the current evidence supporting the integration of MRI into the workflow of AF ablation. Specifically, we examine findings from randomized trials and prospective studies that have investigated the predictive value of MRI-derived fibrosis quantification for procedural outcomes and arrhythmia recurrence. We aim to assess whether MRI can enhance the personalization of ablation strategies and predict treatment success. Challenges such as variability in imaging protocols, lack of standardization in fibrosis quantification, and limited large-scale validation are also addressed. This review provides a comprehensive overview of the current status and potential of MRI in the evolving field of AF ablation.</p>","PeriodicalId":15197,"journal":{"name":"Journal of Cardiovascular Development and Disease","volume":"12 4","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12027483/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143997458","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pre-Workout Supplements and Their Effects on Cardiovascular Health: An Integrative Review.","authors":"Yanesko Fernandes Bella, Samantha Rodrigues Silva Cupido, Pedro Augusto Querido Inacio, Marcelo Luiz Peixoto Sobral, Rodolfo P Vieira","doi":"10.3390/jcdd12040112","DOIUrl":"https://doi.org/10.3390/jcdd12040112","url":null,"abstract":"<p><strong>Introduction: </strong>Dietary supplements have become a popular aid for improving training performance. Pre-workout supplements contain a mixture of ingredients used to boost physical performance, with some components having been associated with the promotion of cardiovascular health. However, there is insufficient scientific literature on the effects of pre-workout supplements, and the studies often have conflicting results.</p><p><strong>Objective: </strong>The aim of this review was to analyze the impact of multi-ingredient pre-workout supplements on cardiovascular health, in order to identify the main adverse effects and the roles of the most common substances in these supplements.</p><p><strong>Methodology: </strong>A systematic search was carried out in the Web of Science and PubMed databases by three independent researchers between January 2010 and August 2024. The inclusion criteria were available articles published in English. Articles that did not evaluate cardiovascular outcomes and the use of pre-workout supplements were excluded.</p><p><strong>Results: </strong>The 24 studies analyzed demonstrated an overall increase in supplement intake. Pre-workout supplements were associated with improved physical performance and possible cardiovascular changes, with these effects being classified as adverse or cardioprotective. This discrepancy in the results may be due to the different dosages and populations investigated (including active and non-active participants, and healthy participants or those with a history of cardiovascular diseases), as well as other factors that correlate with deleterious cardiac conditions.</p><p><strong>Conclusions: </strong>Multi-ingredient pre-workout supplements may offer physical and cardiovascular benefits, including increased energy, focus, endurance, and strength during exercise, as well as having potential positive impacts on blood pressure and triglyceride, low-density lipoprotein (LDL), and homocysteine levels. However, due to the conflicting results of the analyzed studies, additional studies are necessary to fill in the knowledge gaps and establish clearer guidelines for the safe and effective use of these supplements.</p>","PeriodicalId":15197,"journal":{"name":"Journal of Cardiovascular Development and Disease","volume":"12 4","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12028264/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144063949","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Narrative Review of the Evidence for Transcatheter Aortic Valve Implants.","authors":"Leonard Lee, Brendan Min-Wei Chan, Melinda Spencer, Jovi Leung, Danny Liew, Hansoo Kim","doi":"10.3390/jcdd12040113","DOIUrl":"https://doi.org/10.3390/jcdd12040113","url":null,"abstract":"<p><p>Currently, multiple transcatheter aortic valves exist in clinical use, with varying efficacy and safety rates. This review aims to evaluate the evidence base for current transcatheter valves used in the management of aortic stenosis in Australia to improve informed decision making for both clinicians and patients. The evidence base included published peer-reviewed human studies of aortic valves with approval for use in Australia through the Therapeutic Goods Administration (TGA). Embase was utilised on the 17 September 2024, and one hundred ninety-seven publications met the inclusion criteria, including six from citation searching. The Sapien series led with the largest number of patients reported in the literature (<i>n</i> = 91,614) and publications (<i>n</i> = 147), followed by the CoreValve/Evolut series with 65,459 patients and 125 publications. Evidence for both of these transcatheter aortic valve series were also published in high impact journals, with the greatest H-index journal being The New England Journal of Medicine. In conclusion, the evidence base for the safety and efficacy of the Sapien and CoreValve/Evolut series currently leads in both quantity and quality. This review also summarises the Australian medical device regulatory and funding process in the context of transcatheter aortic valves.</p>","PeriodicalId":15197,"journal":{"name":"Journal of Cardiovascular Development and Disease","volume":"12 4","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12027517/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144008325","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}