Journal of Cardiovascular Development and Disease最新文献

{"title":"Effect of Peri-Interventional Blood Loss on In-Stent Thrombosis After Percutaneous Coronary Intervention in Patients with Acute Myocardial Infarction.","authors":"Akram Youssef, Ahmed Mashaly, Usama Alkomi, Marian Christoph, Ahmed Abdelsamad, Silvio Quick, Nesma Elzanaty, Adrian Mahlmann, Karim Ibrahim, Tamer Ghazy","doi":"10.3390/jcdd12020067","DOIUrl":"10.3390/jcdd12020067","url":null,"abstract":"<p><p>This paper evaluates the effect of blood loss on in-stent stenosis after percutaneous coronary intervention (PCI) in patients with acute myocardial infarction (AMI). Nine hundred and ninety-seven patients who underwent PCI for AMI as well as follow-up coronary angiography at 6-12 months from two centers were categorized into three groups based on peri-interventional blood loss at the primary intervention (mild, <1 mmol/L moderate, 1-2 mmol/L; severe > 2 mmol/L). The endpoint was to evaluate the incidence and severity of in-stent stenosis at follow-up angiography and the revascularization rate. The incidence of in-stent stenosis and revascularization in mild, moderate, and severe groups was 19.3%, 33.1%, and 61.1%, respectively (<i>p</i> = 0.001), with HR: 1.35 (95% CI; 1.10-1.65), <i>p</i> < 0.001. Peri-interventional blood loss was associated with a higher incidence of in-stent stenosis and revascularization 6-12 months after successful PCI in patients with AMI.</p>","PeriodicalId":15197,"journal":{"name":"Journal of Cardiovascular Development and Disease","volume":"12 2","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-02-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11856059/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143492157","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cardiological Aspects of Feeding and Eating Disorders in Children and Adolescents and Associations with Refeeding Syndrome, Purging Behaviors, and Psychoactive Drugs.","authors":"Chiara Letizia, Jacopo Pruccoli, Umberto Pannacci, Tania Napolitano, Marianna Fabi, Antonia Parmeggiani","doi":"10.3390/jcdd12020066","DOIUrl":"10.3390/jcdd12020066","url":null,"abstract":"<p><p>Feeding and Eating Disorders (FEDs) constitute a complex spectrum of psychiatric conditions, impacting physical and psychosocial well-being. This retrospective observational study aimed to dissect the electrocardiographic (ECG) alterations in pediatric patients with FEDs, correlating them with clinical factors, treatment modalities, Refeeding Syndrome (RS) and the reversibility of ECG abnormalities post-treatment. Analyzing records from a third level Italian Regional Center for FEDs in children and adolescents, the study encompassed 150 patients meeting the inclusion criteria. Sinus bradycardia was the prevalent ECG alteration, notably in Anorexia Nervosa (AN) restrictive type. Association analyses revealed links between the severity of AN, hormonal imbalances, and amenorrhea and ECG abnormalities. Pharmacological interventions, particularly antipsychotics, exhibited associations with a QT interval prolongation. RS demonstrated significant correlations with potassium and magnesium imbalances, which were linked to specific ECG changes. This study highlighted the reversibility of ECG abnormalities, concomitant with Body Mass Index improvement. This analysis underscores the critical cardiac implications of FEDs, advocating for multidisciplinary interventions and close cardiac monitoring. Early detection and holistic care are imperative in managing patients with FEDs in the developmental age, offering potential reversibility of cardiac alterations post-treatment. These findings underscore the need for prospective studies to validate these observations and delve deeper into cardiac involvement in FEDs.</p>","PeriodicalId":15197,"journal":{"name":"Journal of Cardiovascular Development and Disease","volume":"12 2","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-02-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11856957/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143491978","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Transfemoral Transcatheter Aortic Valve Implantation at Hospitals Without On-Site Cardiac Surgery (TAVI at Home): A Multicenter Prospective Interventional Study.","authors":"Miriam Compagnone, Gianni Dall'Ara, Simone Grotti, Greta Mambelli, Elisabetta Fabbri, Carlo Savini, Marco Balducelli, Andrea Santarelli, Elia Iorio, Beatriz Vaquerizo, Alfredo Marchese, Giuseppe Tarantini, Francesco Saia, Chiara Zingaretti, Carolina Moretti, Caterina Cavazza, Bernadette Vertogen, Filippo Ottani, Andrea Rubboli, Oriana Nanni, Carmine Pizzi, Marcello Galvani, Fabio Felice Tarantino","doi":"10.3390/jcdd12020063","DOIUrl":"10.3390/jcdd12020063","url":null,"abstract":"<p><p>Transcatheter aortic valve implantation (TAVI) has become the standard of care for elderly patients with aortic stenosis. International guidelines recommend that TAVI should be performed only in centers with on-site cardiac surgery (CS). However, rapidly evolving TAVI technology and increasing operator expertise have significantly reduced peri-procedural complications, including those requiring rescue surgery, which occur in less than 0.5% of cases. Furthermore, only a minority of major complications are treated with CS, and the outcomes remain unfavorable. TAVI in centers without CS could represent a solution to reduce waiting times and ensure continuity of care for fragile patients. \"TAVI at Home\" is a single-arm prospective interventional study. According to sample size calculations based on literature data, the study aims to enroll a total of 200 patients, beginning with a run-in phase of 20 patients to establish safety. The primary endpoint is 30-day all-cause mortality. Secondary endpoints include technical success and the evaluation of single complications 30 days after the procedure. Hospitals without CS that are eligible to perform TAVI must have a high volume of coronary percutaneous interventions, operators with established TAVI experience, collaboration with vascular surgeons, and regular Heart Team meetings to ensure rigorous patient selection.</p>","PeriodicalId":15197,"journal":{"name":"Journal of Cardiovascular Development and Disease","volume":"12 2","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-02-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11856494/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143492013","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"ANOCA, INOCA, MINOCA: The New Frontier of Coronary Syndromes.","authors":"Antonio L M Parlati, Ermanno Nardi, Vincenzo Sucato, Cristina Madaudo, Giulio Leo, Tanisha Rajah, Federica Marzano, Maria Prastaro, Paola Gargiulo, Stefania Paolillo, Giuseppe Vadalà, Alfredo Ruggero Galassi, Pasquale Perrone Filardi","doi":"10.3390/jcdd12020064","DOIUrl":"10.3390/jcdd12020064","url":null,"abstract":"<p><p>The growing prevalence in the diagnosis of INOCA (Ischemia with Non-Obstructive Coronary Arteries), ANOCA (Angina with Non-Obstructive Coronary Arteries), and MINOCA (Myocardial Infarction with Non-Obstructive Coronary Arteries) highlights the need to reassess their clinical relevance. Historically regarded as benign syndromes, emerging evidence suggests that these conditions may cause serious cardiovascular events and considerable long-term disability. Additionally, emerging studies suggest that non-obstructive coronary artery disease (CAD) may have a higher prevalence compared to traditional obstructive forms of CAD. This leads to the need to better clarify the underlying pathogenic mechanisms as well as the risk factors associated with these syndromes. This is precisely the aim of this review, which focuses on the complex and heterogeneous mechanisms underlying these syndromes as well as the associated risk factors. This review also sums up the diagnostic steps necessary to achieve an accurate diagnosis, along with the interventional and pharmacological approaches to be implemented in light of the latest evidence.</p>","PeriodicalId":15197,"journal":{"name":"Journal of Cardiovascular Development and Disease","volume":"12 2","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-02-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11856364/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143491967","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Paroxysmal, Persistent, and Permanent Type-1 Brugada Pattern: Does Burden Matter?","authors":"Thanaboon Yinadsawaphan, Pattara Rattanawong, Narathorn Kulthamrongsri, Win-Kuang Shen, Dan Sorajja","doi":"10.3390/jcdd12020065","DOIUrl":"10.3390/jcdd12020065","url":null,"abstract":"<p><p>Spontaneous type-1 Brugada patterns are associated with an elevated risk of major arrhythmic events, yet the relationship between varying degrees of pattern burden and the occurrence of a first major arrhythmic event remains unclear. This retrospective cohort study included 64 adult patients with a spontaneous type-1 Brugada pattern, who were identified at Mayo Clinic sites and followed for ≥12 months after the initial diagnosis. All patients underwent at least three 12-lead electrocardiograms (ECGs) within the first year. Individuals with prior major arrhythmic events were excluded. The percentage of ECGs showing a type-1 pattern was calculated and categorized as paroxysmal (<50%), persistent (50-99%), or permanent (100%). During a median follow-up of 92 months, seven patients (11%) experienced their first major arrhythmic event. Of these, one had paroxysmal, four had persistent, and two had permanent spontaneous type-1 Brugada patterns. Although statistical significance was not reached, the hazard ratios suggested a trend toward increased risk with persistent and permanent patterns compared to paroxysmal patterns. No sudden cardiac deaths occurred during follow-up. These findings suggest that a higher burden of spontaneous type-1 Brugada patterns may be associated with increased arrhythmic risk.</p>","PeriodicalId":15197,"journal":{"name":"Journal of Cardiovascular Development and Disease","volume":"12 2","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-02-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11855952/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143492220","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prothrombotic States in Transcatheter Heart Valve Leaflet Thrombosis (PROSTHESIS): Rationale and Early Results of the Observational Cohort Study.","authors":"Kajetan Grodecki, Katarzyna Pawlak, Matylda Grodecka, Bartosz Rymuza, Piotr Scislo, Olga Ciepiela, Janusz Kochman, Zenon Huczek","doi":"10.3390/jcdd12020062","DOIUrl":"10.3390/jcdd12020062","url":null,"abstract":"<p><p>Subclinical leaflet thrombosis is an imaging phenomenon observed after transcatheter aortic valve implantation (TAVI) and characterized by hypoattenuating leaflet thickening (HALT) on computed tomography angiography. The clinical implications and underlying causes remain uncertain. Hypercoagulability, a component of Virchow's triad, may contribute to thrombus formation on bioprosthetic leaflets, but data on hypercoagulable disorders in TAVI patients and their impact on HALT are limited. The PROSTHESIS study (Prothrombotic States in Transcatheter Heart Valve Subclinical Leaflet Thrombosis) is a single-center observational cohort study aiming to include 130 TAVI patients. This pilot study aimed to (i) assess the effect of hypercoagulable disorders on HALT prevalence and (ii) evaluate their impact on the natural history of HALT. Patients were screened for common hypercoagulable disorders using genetic and functional assays and underwent multimodal imaging one year after TAVI to detect HALT. In patients with HALT, post-implant imaging was repeated after three months to assess its progression. Early results comparing 52 TAVI patients with 52 matched controls undergoing coronary angiography showed similar thrombophilia prevalence between the groups (16% vs. 12%, <i>p</i> = 0.565). HALT occurred in 15% of TAVI patients, more extensively in those with thrombophilia (712 mm³ vs. 135 mm³, <i>p</i> = 0.036). However, thrombophilia was not an independent predictor of HALT. One-year follow-up CTA revealed spontaneous HALT resolution in 63%, stability in 25%, and progression in 12%. This study aims to provide insights into HALT and its mechanisms, which may help prevent complications and improve bioprosthesis durability.</p>","PeriodicalId":15197,"journal":{"name":"Journal of Cardiovascular Development and Disease","volume":"12 2","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-02-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11856029/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143491549","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical Decision Support for Patient Cases with Asymptomatic Carotid Artery Stenosis Using AI Models and Electronic Medical Records.","authors":"Mackenzie Madison, Xiao Luo, Jackson Silvey, Robert Brenner, Kartik Gannamaneni, Alan P Sawchuk","doi":"10.3390/jcdd12020061","DOIUrl":"10.3390/jcdd12020061","url":null,"abstract":"<p><p>An artificial intelligence (AI) analysis of electronic medical records (EMRs) was performed to analyze the differences between patients with carotid stenosis who developed symptomatic disease and those who remained asymptomatic. The EMRs of 872 patients who underwent a carotid endarterectomy between 2009 and 2022 were analyzed with AI. This included 408 patients who had carotid intervention for symptomatic carotid disease and 464 patients for asymptomatic, >70% stenosis. By analyzing the EMRs, the Support Vector Machine achieved the highest sensitivity at 0.626 for predicting which of these patients would go on to develop a stroke or TIA. Random Forest had the highest specificity at 0.906. The risk for stroke in patients with carotid stenosis was a balance between optimum medical treatment and the underlying disease processes. Risk factors for developing symptomatic carotid disease included elevated glucose, chronic kidney disease, hyperlipidemia, and current or recent smoking, while protective factors included cardiovascular agents, antihypertensives, and beta blockers. An AI review of EMRs can help determine which patients with carotid stenosis are more likely to develop a stroke to assist with decision making as to whether to proceed with intervention or to demonstrate and encourage reduced stroke risk with risk factor modification.</p>","PeriodicalId":15197,"journal":{"name":"Journal of Cardiovascular Development and Disease","volume":"12 2","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-02-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11856081/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143492135","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Stroke in Bangladesh: A Narrative Review of Epidemiology, Risk Factors and Acute Stroke Services.","authors":"Mudasar Aziz, Naznin Bipasha, Udit Gupta, Isabela V P Ramnarine, Jessica Redgrave, Ali N Ali, Arshad Majid, Simon M Bell","doi":"10.3390/jcdd12020058","DOIUrl":"10.3390/jcdd12020058","url":null,"abstract":"<p><strong>Introduction: </strong>Stroke is a major cause of mortality and disability worldwide. It is one of the foremost non-communicable diseases and the third leading cause of death in Bangladesh. Bangladesh is a developing country and as such, the prevalence, risk factors and management of the condition has some differences with more Westernised populations. In this review, we look at the epidemiology of stroke in Bangladesh and what barriers exist to improving stroke care in this country.</p><p><strong>Methods: </strong>A systematic search of the PubMed database, Mymensingh Medical Journal, Bangladesh Journal of Neuroscience and Google Scholar was conducted for articles relating to stroke in Bangladesh.</p><p><strong>Results: </strong>The incidence of stroke in Bangladesh is 3 strokes per 1000 people. The prevalence of haemorrhagic stroke is higher than in Western populations, and novel risk factors such as sitting in a squatting position and betel nut chewing increase a Bangladeshi's stroke risk. A lack of education on stroke symptoms and a poor internal infrastructure are the main barriers to improving stroke care in this country.</p><p><strong>Conclusions: </strong>Stroke in Bangladesh is associated with traditional risk factors and non-traditional risk factors that are behaviourally ingrained into the local culture. Improved outcomes for these patients will rely on education programmes for the population, a regard for these risk factors and improving the availability of evidence-based treatments. Innovative approaches from policy decision makers to enhance equitable access to stroke services may help in providing stroke care in Bangladesh.</p>","PeriodicalId":15197,"journal":{"name":"Journal of Cardiovascular Development and Disease","volume":"12 2","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-02-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11856431/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143492006","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical Significance of Serum Omega-3 Fatty Acids on Endothelial Function in Patients with Coronary Artery Disease Under Statin Therapy.","authors":"Kei Yunoki, Hiroaki Matsumi, Toru Miyoshi, Motoki Kubo, Yoshiki Hata, Shinsuke Yuasa","doi":"10.3390/jcdd12020060","DOIUrl":"10.3390/jcdd12020060","url":null,"abstract":"<p><p>Vascular endothelial function plays an important role in the pathogenesis of atherosclerosis. The reduction in low-density lipoprotein cholesterol (LDL-C) is a key therapy for preventing coronary artery disease (CAD), but the role of omega-3 fatty acids as residual risk factors of CAD remains controversial. We studied the correlation between serum omega-3 fatty acid levels and endothelial function in patients with CAD receiving statin therapy and examined the effect of eicosapentaenoic acid (EPA) therapy on endothelial function.</p><p><strong>Methods: </strong>A total of 150 consecutive patients with CAD receiving statin therapy (LDL-C levels < 100 mg/dL) were enrolled. Serum omega-3 fatty acid levels were measured, and endothelial function was assessed by flow-mediated dilation (FMD) of the brachial artery. Subsequently, 65 patients with impaired FMD (<6%) and low EPA/arachidonic acid (AA) (<0.3) were administered EPA, and FMD was reassessed after 3 months.</p><p><strong>Results: </strong>A multivariate linear regression analysis demonstrated that serum docosahexaenoic acid (DHA) and EPA plus DHA levels were independent determinants of %FMD (β = 0.214 and 0.163, <i>p</i> < 0.05, respectively). The EPA therapy significantly improved %FMD (from 3.7 ± 1.0% to 4.1 ± 1.0%, <i>p</i> < 0.05) in patients with low EPA/AA, and especially in patients with low EPA/AA and high triglyceride levels (from 3.4 ± 1.0% to 4.0 ± 1.1%, <i>p</i> < 0.01).</p><p><strong>Conclusions: </strong>Serum omega-3 fatty acid levels were associated with endothelial dysfunction in patients with CAD receiving statin therapy. EPA therapy improves endothelial function in patients with low EPA/AA, especially those with low EPA/AA and high triglycerides.</p>","PeriodicalId":15197,"journal":{"name":"Journal of Cardiovascular Development and Disease","volume":"12 2","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-02-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11856868/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143492072","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessment of Paclitaxel Drug-Coated Balloon-Only Angioplasty for Stent Thrombosis: SPARTAN-ST Study.","authors":"Ioannis Merinopoulos, Bhalraam U, Tharusha Gunawardena, Natasha Corballis, Rajkumar Natarajan, Upul Wickramarachchi, Clint Maart, Sulfi Sreekumar, Chris Sawh, Johannes Reinhold, Trevor Wistow, Alisdair Ryding, Timothy Gilbert, Vassilios S Vassiliou, Simon C Eccleshall","doi":"10.3390/jcdd12020059","DOIUrl":"10.3390/jcdd12020059","url":null,"abstract":"<p><strong>Background: </strong>There are no data regarding the outcomes of patients with stent thrombosis (ST) being treated with drug-coated balloon (DCB) angioplasty. Our aim was to compare the outcomes of patients with ST treated with DCB vs. a drug eluting stent (DES).</p><p><strong>Methods: </strong>In this registry analysis, we identified all patients treated for ST in our institution from June 2011 until November 2019. We excluded patients who died in the cath lab, patients with uncrossable lesions, and patients treated with thrombectomy only. Patient outcomes were obtained from Hospital Episodes Statistics from NHS England. The primary endpoint of this study was the composite of cardiovascular mortality, acute coronary syndrome, or target lesion revascularisation. The data were analysed with Cox regression and Kaplan-Meier estimator plots.</p><p><strong>Results: </strong>A total of 173 patients were identified; 92 treated with DCB-only, 36 with balloon angioplasty (BA), 26 with DES, and 19 with a combination of DES and DCB. We compared the outcomes of 92 patients with DCB versus 20 patients with DES, all of which had presented with late or very late ST. There was no difference between DCB and DES in terms of the primary endpoint (<i>p</i> = 0.06). Multivariate analysis identified diabetes (adverse) and the use of GPIIbIIIa inhibitor (favourable) as the only independent predictors of the primary endpoint. Implantation of a DES was independently associated with worse cardiovascular mortality.</p><p><strong>Conclusions: </strong>This is the first study assessing the outcomes of patients with ST treated with DCB only. It has demonstrated that DCBs are an attractive therapeutic option with a tendency towards favourable outcomes when compared to DESs.</p>","PeriodicalId":15197,"journal":{"name":"Journal of Cardiovascular Development and Disease","volume":"12 2","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-02-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11856968/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143491895","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}