{"title":"正常人和房颤患者肺静脉口的括约肌样功能。","authors":"Stefano Bonapace, Matteo Falanga, Carmelo Cicciò, Cristiana Corsi, Giulio Molon","doi":"10.3390/jcdd12060203","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Early anatomical study suggested that the pulmonary vein (PVs) junction may have putative sphincter-like activity. The aim of this study was to evaluate this activity in normal and paroxysmal/persistent atrial fibrillation subjects.</p><p><strong>Methods: </strong>The Cardiac Computed Tomography (CCT) scans of 45 subjects [15 normal controls, 15 patients with paroxysmal atrial fibrillation (PAR-AF), and 15 with persistent AF (PER-AF)] were retrospectively analyzed. All subjects were in sinus rhythm during the CCT scan. A 3D anatomical model was developed, enabling us to identify the PV ostia and to measure their area dynamic changes during the cardiac cycle.</p><p><strong>Results: </strong>The area changes in the superior PVs within the three groups were significantly higher compared to the inferior (control <i>p</i> = 0.007, PAR-AF <i>p</i> = 0.0003, PER-AF <i>p</i> = 0.04). Moreover, these variations were significantly reduced in PAR-AF and PER-AF compared to the control in all PVs (LSPV (<i>p</i> < 0.001), RSPV (<i>p</i> < 0.001), RIPV (<i>p</i> = 0.037), and LIPV (<i>p</i> < 0.001)).</p><p><strong>Conclusions: </strong>This sphincter-like activity, most prominent in superior PVs, is progressively impaired in patients with paroxysmal and persistent AF.</p>","PeriodicalId":15197,"journal":{"name":"Journal of Cardiovascular Development and Disease","volume":"12 6","pages":""},"PeriodicalIF":2.4000,"publicationDate":"2025-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12194796/pdf/","citationCount":"0","resultStr":"{\"title\":\"A Sphincter-like Function of Pulmonary Vein Ostia in Normal and Atrial Fibrillation Subjects.\",\"authors\":\"Stefano Bonapace, Matteo Falanga, Carmelo Cicciò, Cristiana Corsi, Giulio Molon\",\"doi\":\"10.3390/jcdd12060203\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background: </strong>Early anatomical study suggested that the pulmonary vein (PVs) junction may have putative sphincter-like activity. The aim of this study was to evaluate this activity in normal and paroxysmal/persistent atrial fibrillation subjects.</p><p><strong>Methods: </strong>The Cardiac Computed Tomography (CCT) scans of 45 subjects [15 normal controls, 15 patients with paroxysmal atrial fibrillation (PAR-AF), and 15 with persistent AF (PER-AF)] were retrospectively analyzed. All subjects were in sinus rhythm during the CCT scan. A 3D anatomical model was developed, enabling us to identify the PV ostia and to measure their area dynamic changes during the cardiac cycle.</p><p><strong>Results: </strong>The area changes in the superior PVs within the three groups were significantly higher compared to the inferior (control <i>p</i> = 0.007, PAR-AF <i>p</i> = 0.0003, PER-AF <i>p</i> = 0.04). Moreover, these variations were significantly reduced in PAR-AF and PER-AF compared to the control in all PVs (LSPV (<i>p</i> < 0.001), RSPV (<i>p</i> < 0.001), RIPV (<i>p</i> = 0.037), and LIPV (<i>p</i> < 0.001)).</p><p><strong>Conclusions: </strong>This sphincter-like activity, most prominent in superior PVs, is progressively impaired in patients with paroxysmal and persistent AF.</p>\",\"PeriodicalId\":15197,\"journal\":{\"name\":\"Journal of Cardiovascular Development and Disease\",\"volume\":\"12 6\",\"pages\":\"\"},\"PeriodicalIF\":2.4000,\"publicationDate\":\"2025-05-28\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12194796/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of Cardiovascular Development and Disease\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.3390/jcdd12060203\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"CARDIAC & CARDIOVASCULAR SYSTEMS\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Cardiovascular Development and Disease","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.3390/jcdd12060203","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"CARDIAC & CARDIOVASCULAR SYSTEMS","Score":null,"Total":0}
引用次数: 0
摘要
背景：早期解剖研究提示肺静脉（pv）连接处可能有类似括约肌的活动。本研究的目的是评估正常和阵发性/持续性心房颤动受试者的这种活动。方法：回顾性分析45例患者（15例正常对照，15例阵发性心房颤动（PAR-AF）， 15例持续性心房颤动（PER-AF））的心脏计算机断层扫描（CCT）。所有受试者在CCT扫描时均处于窦性心律。建立了三维解剖模型，使我们能够识别PV口并测量其在心脏周期内的面积动态变化。结果：三组上侧pv面积变化均显著高于下侧pv （control p = 0.007, PAR-AF p = 0.0003, PER-AF p = 0.04）。此外，与对照组相比，所有pv (LSPV (p < 0.001), RSPV （p < 0.001), RIPV （p = 0.037）和LIPV (p < 0.001)）的PAR-AF和PER-AF的这些变异显著减少。结论：在阵发性和持续性房颤患者中，这种约括肌样活动（在上pv中最为突出）逐渐受损。
A Sphincter-like Function of Pulmonary Vein Ostia in Normal and Atrial Fibrillation Subjects.
Background: Early anatomical study suggested that the pulmonary vein (PVs) junction may have putative sphincter-like activity. The aim of this study was to evaluate this activity in normal and paroxysmal/persistent atrial fibrillation subjects.
Methods: The Cardiac Computed Tomography (CCT) scans of 45 subjects [15 normal controls, 15 patients with paroxysmal atrial fibrillation (PAR-AF), and 15 with persistent AF (PER-AF)] were retrospectively analyzed. All subjects were in sinus rhythm during the CCT scan. A 3D anatomical model was developed, enabling us to identify the PV ostia and to measure their area dynamic changes during the cardiac cycle.
Results: The area changes in the superior PVs within the three groups were significantly higher compared to the inferior (control p = 0.007, PAR-AF p = 0.0003, PER-AF p = 0.04). Moreover, these variations were significantly reduced in PAR-AF and PER-AF compared to the control in all PVs (LSPV (p < 0.001), RSPV (p < 0.001), RIPV (p = 0.037), and LIPV (p < 0.001)).
Conclusions: This sphincter-like activity, most prominent in superior PVs, is progressively impaired in patients with paroxysmal and persistent AF.
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