{"title":"Numerical modelling of airflow and aerosol particle delivery in cats with bronchial and non-bronchial disease","authors":"Carla Zamora-Perarnau , Mauro Malvè , Rocío Fernández-Parra","doi":"10.1016/j.jbiomech.2026.113233","DOIUrl":"10.1016/j.jbiomech.2026.113233","url":null,"abstract":"<div><div>Feline lower airway disease comprises a spectrum of inflammatory conditions, including asthma, which is commonly treated with inhaled glucocorticoids. This study employs computed tomography (CT)–based computational fluid dynamics (CFD) models to characterize airflow dynamics in feline lower airways with and without bronchial disease (BD and NBD), evaluating velocity, pressure, wall shear stress, and airway resistance under different flow conditions. In addition, deposition patterns of two aerosol particle sizes (1 µm and 10 µm) were assessed within the trachea and bronchi.</div><div>Geometrical reconstructions of the trachea and lobar bronchi were generated from CT scans of 24 cats, classified into BD and NBD groups. Simulations were performed using two airflow conditions and two particle diameters. Airflow parameters and aerosol particle deposition were calculated for each model.</div><div>A trend toward higher values of most airflow parameters was observed in the NBD group, except for expiratory resistance and velocity. However, no statistically significant differences in airflow parameters were identified between groups. Particle deposition analysis showed a higher deposition fraction for larger particles, with 10 µm particles depositing more frequently on bronchial walls than 1 µm particles in both groups.</div><div>Overall, CT-based CFD analysis revealed no significant group differences in resistance, pressure, wall shear stress, or velocity. Nevertheless, particle size influenced deposition patterns, with larger particles showing increased bronchial trapping. Although the initial hypothesis was not confirmed, this feasibility and characterization study establishes a methodological framework for future <em>in silico</em> investigations of feline lower airway disease providing preliminary physiologically and clinically relevant insights.</div></div>","PeriodicalId":15168,"journal":{"name":"Journal of biomechanics","volume":"200 ","pages":"Article 113233"},"PeriodicalIF":2.4,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147365297","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Journal of biomechanicsPub Date : 2026-05-01Epub Date: 2026-02-06DOI: 10.1016/j.jbiomech.2026.113186
Yasuko Hirono, Norihisa Fujii
{"title":"Modes of centripetal ground reaction force application in curved sprinting on an athletic track in male athletes","authors":"Yasuko Hirono, Norihisa Fujii","doi":"10.1016/j.jbiomech.2026.113186","DOIUrl":"10.1016/j.jbiomech.2026.113186","url":null,"abstract":"<div><div>Curve sprinting requires a centripetal ground reaction force (GRF) impulse, causing biomechanical leg asymmetries. However, the strategies for modulating this impulse, its primary determinants (contact duration versus GRF magnitude), and specific joint kinetic and kinematic contributions remain unclear. This study investigated these impulse determinants and identified lower-limb factors associated with the magnitude of the GRF to elucidate asymmetrical leg modes in curve sprinting. Fifteen experienced male sprinters performed submaximal sprints on a 42-m-radius curve. Three-dimensional kinematic data and GRFs were recorded, joint torques were calculated, and partial least squares regression (PLSR) was used to assess key relationships. The centripetal impulse was strongly correlated with the mean centripetal GRF for both legs but not with the contact duration. Thus, the mean centripetal GRF, rather than the contact duration, was the primary determinant of the centripetal impulse during curve sprinting for both legs, supporting our first hypothesis. The PLSR results revealed functionally distinct asymmetrical modes: the left leg engaged in a complex turning and stability mode, defined by specific hip/ankle torques, and suppressed outward push. Conversely, the right leg relied on a dominant whole-limb inclination of the knee and ankle joint axis, along with a contribution from the ankle plantarflexion torque. These findings highlight distinct asymmetrical mechanisms of GRF application, thereby advancing our understanding of curve-sprinting biomechanics.</div></div>","PeriodicalId":15168,"journal":{"name":"Journal of biomechanics","volume":"200 ","pages":"Article 113186"},"PeriodicalIF":2.4,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147387723","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Journal of biomechanicsPub Date : 2026-05-01Epub Date: 2026-03-03DOI: 10.1016/j.jbiomech.2026.113236
Kristen Steudel , Nicos Haralabidis , Reed Gurchiek , Jennifer Hicks , Scott Delp
{"title":"Knee and hip joint dynamics differ between sprinting and Nordic hamstring exercises","authors":"Kristen Steudel , Nicos Haralabidis , Reed Gurchiek , Jennifer Hicks , Scott Delp","doi":"10.1016/j.jbiomech.2026.113236","DOIUrl":"10.1016/j.jbiomech.2026.113236","url":null,"abstract":"<div><div>Sprinting and the Nordic hamstring exercise (NHE) are common training modalities used to reduce hamstring injury risk, but the differences in the biomechanical demands of sprinting and the NHE are unclear. We conducted an exploratory analysis comparing knee and hip joint kinematics and kinetics, and biceps femoris long head (BFLH) muscle–tendon unit length and velocity during the flight phase of sprinting and the NHE. We collected motion capture and force data from fourteen athletic participants (8 males, 6 females) running (4–8 m/s) and performing the NHE. We used this experimental data and musculoskeletal modeling to compute joint kinematics and kinetics and estimate the BFLH muscle–tendon unit length and velocity for all running speeds and the NHE. Sprinting, for all speeds, puts the BFLH at longer lengths (<em>p</em> < 0.001) and higher lengthening velocities (<em>p</em> < 0.001) than the NHE. The NHE requires participants to generate peak knee flexion moments that are smaller than for running at 6 m/s and above (<em>p</em> < 0.001), and peak negative knee flexion powers that are less than 5% of all running speeds (<em>p</em> < 0.001). However, the duration of each NHE repetition is approximately 60 times longer than the BFLH lengthening portion of the flight phase of running, resulting in greater negative knee work for running at 6 m/s and below (<em>p</em> < 0.001) but less at 7.5 m/s and above (<em>p</em> < 0.001). The results of this study provide necessary quantitative information to compare the biomechanical demands of sprinting and the NHE.</div></div>","PeriodicalId":15168,"journal":{"name":"Journal of biomechanics","volume":"200 ","pages":"Article 113236"},"PeriodicalIF":2.4,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147387724","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Journal of biomechanicsPub Date : 2026-05-01Epub Date: 2026-03-03DOI: 10.1016/j.jbiomech.2026.113235
Toru Sakuma, Kensaku Kimura
{"title":"Kinetics of the trunk in association with the attenuation of upper body acceleration during walking","authors":"Toru Sakuma, Kensaku Kimura","doi":"10.1016/j.jbiomech.2026.113235","DOIUrl":"10.1016/j.jbiomech.2026.113235","url":null,"abstract":"<div><div>The acceleration amplitude of body segments during walking is reduced from the ankle to the head. The primary function of shock absorption is performed by the legs, with the trunk also contributing. The aim of this study was to investigate the capability of the trunk to absorb shock during walking. Twenty healthy participants walked at their preferred and unnatural walk ratio (WR) (step length/cadence) at a constant speed. The unnatural WRs comprised 6 cadences (±10%, ±15%, and ± 20% of preferred cadence). Shock absorption was evaluated using the root mean square acceleration at the head (RMS<sub>H</sub>) and lower trunk (RMS<sub>T</sub>), the coefficient of attenuation from RMS<sub>T</sub> to RMS<sub>H</sub>, as well as the trunk joint torque and power. RMS<sub>H</sub> and RMS<sub>T</sub> in the anterior-posterior direction (AP) showed a significant increase (<em>p</em> < 0.05) in high WRs (slower cadence) and a significant decrease (<em>p</em> < 0.05) in low WRs (faster cadence) compared to the preferred WR. The attenuation coefficient in the AP was significantly decreased in high WRs than in the preferred WR (<em>p</em> < 0.05). The average negative power of the flexion–extension torque at the trunk joint had a significant negative correlation (<em>p</em> < 0.001) with RMS<sub>T</sub> in the AP. These results suggested that trunk flexion–extension torque played a role in the shock absorption, and this negative power increased in response to an increase in RMS<sub>T</sub> in the AP. However, given the limitation of the trunk’s shock absorption capacity, the RMS<sub>H</sub> in the AP was more pronounced at high WR.</div></div>","PeriodicalId":15168,"journal":{"name":"Journal of biomechanics","volume":"200 ","pages":"Article 113235"},"PeriodicalIF":2.4,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147365368","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Journal of biomechanicsPub Date : 2026-05-01Epub Date: 2026-03-03DOI: 10.1016/j.jbiomech.2026.113237
Steven Ayala , Michelle L. Delco , Lisa A. Fortier , Itai Cohen , Lawrence J. Bonassar
{"title":"Articular chondrocytes from the knee and ankle have different sensitivities to shear strain","authors":"Steven Ayala , Michelle L. Delco , Lisa A. Fortier , Itai Cohen , Lawrence J. Bonassar","doi":"10.1016/j.jbiomech.2026.113237","DOIUrl":"10.1016/j.jbiomech.2026.113237","url":null,"abstract":"<div><div>Traumatic injury to synovial joints results in focal defects and proinflammatory changes in cartilage tissue, eventually leading to post-traumatic osteoarthritis (PTOA). Additionally, disparate incidence rates of PTOA occur between joints, particularly the knee and ankle. We hypothesize that differences in PTOA rates between knee and ankle cartilage are related to inherent differences in mechanical properties and chondrocyte sensitivity to mechanical loads. Our objective was to compare the effect of injury on the spatial patterns of cellular response between knee and ankle cartilage and relate these responses to changes in tissue mechanical properties. Cartilage explants of neonatal bovids from the talar dome of the ankle and femoral condyle of the knee were subjected to our ex vivo combined injury model which combines rapid impact injury and repetitive cartilage articulation. Explants were bisected and fluorescently stained to assess global and depth-dependent cell death, caspase activity, and mitochondrial depolarization. Explants were tested via confocal elastography to determine the local shear strain and shear modulus profile. Results showed that chondrocyte response differed between joints, with knee cartilage showing greater damage within the surface region. Additionally, ankle cartilage experienced a greater decrease in shear modulus post-injury compared to knee, causing depth-dependent shear strain to significantly increase (<em>p</em> < 0.0287). Furthermore, regression analyses relating cellular response to local shear strain revealed joint-specific differences in chondrocyte sensitivity, defined as the slope of cellular response versus shear strain, for cell death (knee: 873 vs ankle: 551), apoptosis (knee: 7779 vs ankle: 3577), and MT depolarization (knee: 848 vs ankle: 535).</div></div>","PeriodicalId":15168,"journal":{"name":"Journal of biomechanics","volume":"200 ","pages":"Article 113237"},"PeriodicalIF":2.4,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147377378","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Journal of biomechanicsPub Date : 2026-04-01Epub Date: 2026-02-17DOI: 10.1016/j.jbiomech.2026.113219
Florent Moissenet , Benjamin Michaud , Pierre Puchaud , Nicola Hagemeister , Mickaël Begon , Nicolas Holzer
{"title":"Average rotation matrices for converting scapula- and glenoid-based coordinate systems to ISB recommendations","authors":"Florent Moissenet , Benjamin Michaud , Pierre Puchaud , Nicola Hagemeister , Mickaël Begon , Nicolas Holzer","doi":"10.1016/j.jbiomech.2026.113219","DOIUrl":"10.1016/j.jbiomech.2026.113219","url":null,"abstract":"<div><div>Defining bone-embedded local coordinate systems (LCSs) is fundamental in shoulder biomechanics, yet multiple scapular LCSs exist, hindering data comparison. Although the International Society of Biomechanics (ISB) has published recommendations, alternative definitions based on distinct anatomical landmarks remain often used. To address these inconsistencies, average rotation matrices were recently proposed to convert between the three most common scapular LCSs, thereby facilitating comparison, merging, and interoperability between datasets. Building upon this, we have extended the approach to 11 scapular LCSs reported in the literature, including scapula- and glenoid-based systems. Using statistical shape models derived from 80 participants (asymptomatic and pathological shoulders), 1000 scapulae were generated to quantify geometric transformations between LCSs. Average rotation matrices were computed for each alternative system relative to the ISB-recommended LCS, and accuracy was assessed using helical angles. The application of the average rotation matrices substantially reduced the maximal discrepancies between LCSs, from 21.9° to 5.2°. Scapula-based systems exhibited lower discrepancies than glenoid-based ones, reflecting greater morphological variability in the glenoid region. Comparisons with previously published matrices showed minimal differences (<3°), supporting the robustness of the approach across various datasets and population. These findings confirm that average rotation matrices provide a reliable means of harmonising scapular kinematic data across studies, even if experimenters initially chose a different LCS. This work offers a simple framework, for bridging existing scapular kinematic datasets and promoting interoperability datasets in shoulder biomechanics research.</div></div>","PeriodicalId":15168,"journal":{"name":"Journal of biomechanics","volume":"199 ","pages":"Article 113219"},"PeriodicalIF":2.4,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146776386","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Journal of biomechanicsPub Date : 2026-04-01Epub Date: 2026-01-25DOI: 10.1016/j.jbiomech.2026.113187
Lucy Armitage , Kenny Cho , Tawnee L. Sparling , Todd Sleeman , Gursel Alici , Manish Sreenivasa
{"title":"The use of residual lower limb –prosthetic socket interface pressure measurements to inform clinical decisions: A systematic review","authors":"Lucy Armitage , Kenny Cho , Tawnee L. Sparling , Todd Sleeman , Gursel Alici , Manish Sreenivasa","doi":"10.1016/j.jbiomech.2026.113187","DOIUrl":"10.1016/j.jbiomech.2026.113187","url":null,"abstract":"<div><div>This systematic review aims to synthesise and consolidate existing knowledge on the relationship between socket interface pressure measurement and outcome measures related to clinical parameters of socket comfort in lower-limb prosthetic sockets. A search of Scopus, Web of Science, MEDLINE, CINAHL, Cochrane database of systematic reviews and IEEE Xplore was performed up to 2nd August 2024. A total of 19 studies were included in the data extraction and quality assessment process. Most studies were moderate to high quality. Extracted data included a variety of sensing systems, predominantly on male subjects with transtibial amputation, measuring normal forces or pressure. Loads were associated with comfort, discomfort, satisfaction, pain onset or pain tolerance, tissue safety and changes to satisfaction over time. There were no studies reporting any of these outcomes for people with impaired sensation or phantom limb pain. Although, there was no consistent identifiable threshold associated with a comfort or discomfort condition for any region or activity between studies, measurements at some bony regions during dynamic or activity associated with higher interface loading allowed differentiation between comfortable and uncomfortable socket conditions across studies. The synthesis of the reported pressure measurements could be a starting point for the iterative process of developing tissue-safe pressure thresholds or ranges for use in long term socket fit monitoring or to assist clinicians and prosthesis users in defining socket fit and comfort.</div></div>","PeriodicalId":15168,"journal":{"name":"Journal of biomechanics","volume":"199 ","pages":"Article 113187"},"PeriodicalIF":2.4,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147306205","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Journal of biomechanicsPub Date : 2026-04-01Epub Date: 2026-02-13DOI: 10.1016/j.jbiomech.2026.113217
Jon Stingel , Nicos Haralabidis , Jennifer Hicks , Scott Uhlrich , Scott Delp
{"title":"Running with an exotendon reduces compressive knee contact force","authors":"Jon Stingel , Nicos Haralabidis , Jennifer Hicks , Scott Uhlrich , Scott Delp","doi":"10.1016/j.jbiomech.2026.113217","DOIUrl":"10.1016/j.jbiomech.2026.113217","url":null,"abstract":"<div><div>An exotendon—a spring that couples the legs when attached to a runner’s shoes—reduces the energetic cost of running, but the effects on joint contact forces are unknown. This study examined whether running with an exotendon alters the forces in the hip, knee and ankle. We used muscle-driven simulations of experimental data to compute compressive and shear contact forces at the hip, knee, and ankle joints for seven participants running at 2.7 m/s with and without an exotendon. We found that runners using the exotendon experienced a 8.4% reduction in peak knee compressive contact force (1.0 ± 0.7 BW; <em>P</em> = 0.026), and no change in the peak knee shear contact force. The primary contributor to this reduction was lower forces in the quadriceps muscles, which decreased their contribution to peak knee compressive contact force by 12.2% (−0.8 ± 0.7 BW; <em>P</em> = 0.018). We observed no change in the peak compressive or shear contact forces in the hip or ankle joints. Though the exotendon was not originally designed to reduce joint forces, our findings highlight the ability of this simple device to make changes to gait that reduce both energetic cost and compressive knee force.</div></div>","PeriodicalId":15168,"journal":{"name":"Journal of biomechanics","volume":"199 ","pages":"Article 113217"},"PeriodicalIF":2.4,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147306253","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Journal of biomechanicsPub Date : 2026-04-01Epub Date: 2026-02-26DOI: 10.1016/j.jbiomech.2026.113231
Yanlong Zhang , Yanyu Yin , Xiao Yu , Minghe Sun , Gengchao Bi , Si Chen
{"title":"Dynamic regulation of Lower-Limb joint loading during Foot-Abducted landing in wide Lunge: An analysis of muscle synergy and neuromuscular activation patterns","authors":"Yanlong Zhang , Yanyu Yin , Xiao Yu , Minghe Sun , Gengchao Bi , Si Chen","doi":"10.1016/j.jbiomech.2026.113231","DOIUrl":"10.1016/j.jbiomech.2026.113231","url":null,"abstract":"<div><div>This study compares the relative contribution of knee joint medial and lateral compartmental loading, muscle synergy, and activation characteristics between two types of wide-lunge landing strategies to reveal the neuromuscular mechanisms by which foot-abducted landings reduce injury risk. Twenty male badminton players performed the lunge with two foot orientations: heel-to-second metatarsal (foot-forward) and 20° foot abduction (foot-abducted). The foot-abducted landing significantly reduced medial compartment peak shear force and pressure contributions from the semitendinosus, vastus medialis, and vastus lateralis (P < 0.05). It also decreased lateral compartment moments and muscle contributions from the biceps femoris, rectus femoris, and medial gastrocnemius (P < 0.05). Among the four identified muscle synergies, Syn1 was primarily active before landing. In foot-abducted landings, Syn2 exhibited higher activation of the vastus medialis and vastus lateralis (P < 0.05), while Syn3 showed greater gastrocnemius involvement (P < 0.05). Additionally, the co-activation index indicated higher gastrocnemius activity in foot-abducted landings (P < 0.05). These findings suggest that landing with foot abduction and initial lateral heel contact realigns force vectors, reducing knee joint loading. This strategy promotes a shift from single-joint control to a multi-joint kinetic-chain synergy, demonstrating a neuromuscular pattern associated with lower injury risk.</div></div>","PeriodicalId":15168,"journal":{"name":"Journal of biomechanics","volume":"199 ","pages":"Article 113231"},"PeriodicalIF":2.4,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147326012","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Journal of biomechanicsPub Date : 2026-04-01Epub Date: 2026-02-08DOI: 10.1016/j.jbiomech.2026.113201
Dylan Heino , Scott Telfer , Avocet Nagle-Christensen , William R. Ledoux , Brittney C. Muir
{"title":"Quantifying differences in high-pressure region mapping between dynamic in-shoe and barefoot plantar pressure in diabetic subjects","authors":"Dylan Heino , Scott Telfer , Avocet Nagle-Christensen , William R. Ledoux , Brittney C. Muir","doi":"10.1016/j.jbiomech.2026.113201","DOIUrl":"10.1016/j.jbiomech.2026.113201","url":null,"abstract":"<div><div>Foot ulceration is a serious complication of diabetes, often linked to elevated forefoot pressures during walking. Custom accommodative insoles reduce peak plantar pressures, with greater reductions achieved when dynamic pressure data informs design. While in-shoe and barefoot data are used separately to design insoles, their agreement in pressure distribution and high-pressure region location has not been evaluated. This study compares pressure distribution and high-pressure region mapping between in-shoe and barefoot data.</div><div>In-shoe and barefoot pressures were recorded during walking for 25 feet from 16 individuals with high forefoot pressures. High-pressure regions were masked, grouped, and labeled by anatomical region. In-shoe and barefoot pressure maps were averaged over trials and overlaid, and peak pressure and contact area were calculated for all high-pressure regions. For matched regions, centroid locations were compared.</div><div>In-shoe high-pressure regions (>200 kPa) were typically observed in similar locations to barefoot walking, while barefoot maps often identified additional regions (>450 kPa) in the toes and lateral forefoot. For in-shoe data, these regions had lower peak pressures and larger contact areas. Matched regions’ centroid positions differed by 0.23–0.60 cm.</div><div>Key loading areas were consistent between systems, though unmatched regions were common, particularly in barefoot data, reflecting greater sensitivity to localized pressures. Barefoot data may overestimate high-risk regions that do not display elevated in-shoe pressures. Basing offloading insole design on threshold-based barefoot high-pressure regions could reduce specificity and limit pressure reduction for in-shoe high-pressure regions. These findings have potential implications for streamlining clinical workflows during pressure-informed insole design.</div></div>","PeriodicalId":15168,"journal":{"name":"Journal of biomechanics","volume":"199 ","pages":"Article 113201"},"PeriodicalIF":2.4,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147348343","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}