Journal of biomechanics最新文献

{"title":"Three-dimensional kinematics in patients with anterior shoulder instability – A systematic review with meta-analysis","authors":"Talissa Oliveira Generoso ,&nbsp;Vitor La Banca ,&nbsp;Felipe F. Gonzalez ,&nbsp;João Artur Bonadiman ,&nbsp;Lucas Valerio Pallone ,&nbsp;Eliane C. Guadagnin ,&nbsp;Grant E. Garrigues ,&nbsp;Jonathan A. Gustafson ,&nbsp;Leonardo Metsavaht ,&nbsp;Gustavo Leporace","doi":"10.1016/j.jbiomech.2025.112543","DOIUrl":"10.1016/j.jbiomech.2025.112543","url":null,"abstract":"<div><div>Anterior Shoulder Instability (ASI) is a common orthopedic condition often resulting in altered shoulder kinematics. Understanding the biomechanics of the unstable shoulder is critical to determine the most appropriate treatment. This study aims to conduct the first systematic review and <em>meta</em>-analysis of three-dimensional (3D) shoulder kinematic studies in ASI patients. A broad search was conducted within PubMed, Scopus, and Cochrane Library following the PRISMA guidelines. All cross-sectional or longitudinal studies with 3D motion analysis describing shoulder kinematics in patients with ASI were included. The quality of each study was assessed using the MINORS criteria. Qualitative and quantitative analyses were performed. Nine studies were included in the qualitative analysis and two in the <em>meta</em>-analysis. The qualitative review detected conflicting evidence for some parameters. The humeral head had a greater anterior translation in unstable shoulders in three of the studies analyzed, while the difference was not significant in one and another found higher variability for global humeral translation for instability patients. Two studies showed decreased rotation range of motion for unstable shoulders while one did not find significant differences. Conflicting results were also found regarding changes in scapulohumeral rhythm and scapular orientation. The <em>meta</em>-analysis indicated a greater scapulohumeral rhythm on the coronal plane for the instability group, suggesting a relatively greater contribution of motion at the glenohumeral joint compared with the scapulothoracic joint for arm abduction, and reduced glenohumeral peak angles for unstable shoulders. Identifying and quantifying kinematic changes associated with ASI are vital for refining treatment interventions.</div></div>","PeriodicalId":15168,"journal":{"name":"Journal of biomechanics","volume":"181 ","pages":"Article 112543"},"PeriodicalIF":2.4,"publicationDate":"2025-01-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143038614","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Biomechanical correlates of gait and stair climbing are associated with ex vivo cartilage quality in gonarthrotic patients","authors":"Ramona Ritzmann ,&nbsp;Jochen Paul ,&nbsp;Jürg Gasser ,&nbsp;Janine Kuch ,&nbsp;Yufei Li ,&nbsp;Ines Honorio ,&nbsp;Agnese Beretta-Picoli ,&nbsp;Arno Doelemeyer ,&nbsp;Angelika Meyer ,&nbsp;Lukas Hils ,&nbsp;Stefan Utzinger ,&nbsp;Albrecht Heitner ,&nbsp;Carsten Jacobi ,&nbsp;Christoph Centner","doi":"10.1016/j.jbiomech.2025.112546","DOIUrl":"10.1016/j.jbiomech.2025.112546","url":null,"abstract":"<div><div>Previous evidence highlights the important role of knee joint malalignment and excessive joint moments for the development to knee osteoarthritis. The present study aimed to systematically investigate the interrelationship between three-dimensional knee kinematics during walking and stair climbing and ex-vivo electromechanical measured cartilage quality in 119 patients with end-stage knee osteoarthritis. Patients scheduled for total knee arthroplasty surgery underwent radiographic assessment and biomechanical analysis in gait and stair climbing assessing in vivo knee joint angles and moments during movement dynamics prior to surgery. Electromechanical properties of the excised tibial cartilage as an indicator of cartilage quality were evaluated using Arthro-BST. Peak knee adduction angle was found to be a significant predictor of medial cartilage quality during walking (<em>R</em>² = 22 %, <em>p</em> &lt; 0.001) and stair climbing (<em>R</em>² = 13 %, <em>p</em> &lt; 0.001). During walking, knee flexion moment was found to be a strong predictor of medial (<em>R</em>² = 9 %, <em>p</em> = 0.002) and lateral cartilage quality (<em>R</em>² = 12 %, <em>p</em> &lt; 0.001). Knee adduction (<em>R</em>² = 19 %, <em>p</em> &lt; 0.001) and abduction angles (<em>R</em>² = 44 %, <em>p</em> &lt; 0.01) during x-ray was significantly associated with dynamic assessments during 3D kinematics. Medial joint space width significantly predicted medial tibial cartilage quality (<em>R</em>² = 16 %, <em>p</em> &lt; 0.001).</div><div>The results showed that biomechanical parameters such as varus malalignment during walking and stair climbing are significantly associated with tibial cartilage deterioration and contribute to a variance explanation of 13–22%.</div></div>","PeriodicalId":15168,"journal":{"name":"Journal of biomechanics","volume":"181 ","pages":"Article 112546"},"PeriodicalIF":2.4,"publicationDate":"2025-01-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143065900","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hemodynamic investigations on the portal hypertension and treatment of transjugular intrahepatic portosystemic shunt (TIPS) based on CFD simulation","authors":"Wenzhi Gao ,&nbsp;Chunzhen Yin ,&nbsp;Chunze Zhou ,&nbsp;Delei Cheng ,&nbsp;Jian Chen ,&nbsp;Changhai Liu ,&nbsp;Yishan Zeng","doi":"10.1016/j.jbiomech.2025.112516","DOIUrl":"10.1016/j.jbiomech.2025.112516","url":null,"abstract":"<div><div>Hemodynamic processes from the portal vein(PV) to the inferior vena cava(IVC) were mimicked for three patients with portal hypertension(PH) and the effects of stent parameters on the outcomes of transjugular intrahepatic portosystemic shunt(TIPS) were investigated through computational fluid dynamics(CFD). The liver region was simulated with porous media model and the spatial distributions of superior mesenteric vein(SMV) and splenic vein(SV) blood were solved through the Eulerian multiphase model. The present method is able to simulate the PH flow and predict the PV pressure, the stent shunt rate and the SMV blood proportion after TIPS treatment. According to the CFD results, the stent diameter exerts dominant effects on the TIPS outcomes while the stent placement shows substantial effects on the TIPS outcomes. Energy loss of the TIPS stents and distributary effects of the PV bifurcation dominate the PV hemodynamics and the TIPS outcomes. For stents with large diameter or proper placement, the energy loss is low therefore the PV pressure reduction and stent shunt rate are high. Stents inserted on the left and right branches of the PV are able to utilize distributary effects of the PV bifurcation therefore reduce the SMV blood flowing into the IVC.</div></div>","PeriodicalId":15168,"journal":{"name":"Journal of biomechanics","volume":"181 ","pages":"Article 112516"},"PeriodicalIF":2.4,"publicationDate":"2025-01-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143059124","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Anticipation augments distal leg muscle neuromechanics before, during, and after treadmill-induced perturbations applied during walking","authors":"Emily K. Eichenlaub ,&nbsp;Jessica Allen ,&nbsp;Vicki S. Mercer ,&nbsp;Jeremy R. Crenshaw ,&nbsp;Jason R. Franz","doi":"10.1016/j.jbiomech.2025.112547","DOIUrl":"10.1016/j.jbiomech.2025.112547","url":null,"abstract":"<div><div>We investigated the effect of anticipation on the proactive and reactive neuromechanical responses of the distal leg muscles in 20 young adults to anticipated and unanticipated rapid anterior or posterior treadmill-induced balance perturbations applied during walking. We quantified local medial gastrocnemius (MG) and tibialis anterior (TA) neuromechanics using cine B-mode ultrasound and surface electromyography before, during, and after the perturbation. Our findings partially supported the hypothesis that anticipated perturbations would elicit greater proactive agonist muscle adjustments than unanticipated perturbations. Though, these adjustments were direction-dependent; MG showed greater activation in anticipation of accelerations while TA activation did not change in anticipation of decelerations. Our findings contradicted our second hypothesis that unanticipated perturbations would elicit larger reactive agonist muscle responses than anticipated perturbations. Anticipated perturbations elicited greater agonist muscle excitations with no changes in muscle fascicle kinematics during the perturbed and recovery strides, suggesting that anticipation allows for greater force responsiveness of distal leg muscles when disrupted by a perturbation. Our results may inform remote monitoring of stability and balance using portable measurement tools, such as EMG and ultrasound, to monitor muscle dynamics in real time and mitigate the risk of falls.</div></div>","PeriodicalId":15168,"journal":{"name":"Journal of biomechanics","volume":"181 ","pages":"Article 112547"},"PeriodicalIF":2.4,"publicationDate":"2025-01-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143065876","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Motor variability regulation analysis in trampolinists","authors":"Mathieu Bourgeois ,&nbsp;Eve Charbonneau ,&nbsp;Craig Turner,&nbsp;Mickaël Begon","doi":"10.1016/j.jbiomech.2025.112533","DOIUrl":"10.1016/j.jbiomech.2025.112533","url":null,"abstract":"<div><div>In trampolining, optimizing body orientation during landing reduces injury risk and enhances performance. As trampolinists are subject to motor variability, anticipatory inflight corrections are necessary to regulate their body orientation before landing. We investigated the evolution of a) body orientation and b) limb position (<em>i.e.</em>, arms and legs) variabilities. Secondary objectives were to investigate c) the link between acrobatics difficulty and the variability accumulation, and d) to identify links between body orientation variability and gaze orientation. Kinematics and gaze orientation were captured using inertial measurement units and an eye tracker, respectively. Seventeen trampolinists performed up to 13 different acrobatics (different number of rotations in twist and somersault). Intra-trampolinist pelvis orientation and limb position inter-trial variability was computed for each acrobatic at three key timestamps: takeoff, 75 % completion of the twist, and landing. Pelvis orientation variability significantly increased between takeoff and the instant when 75 % of the twist is completed (+75 %) and then decreased from the instant when 75 % of the twist is completed until landing (−39 %). Conversely, limb variability decreased (upper limbs: −66 % and lower limbs: −46 %), before increasing (+357 % and +127 %), suggesting that trampolinists adapted their limb kinematics to regulate pelvis orientation before landing. It was qualitatively observed that this decrease in body orientation variability occurred mostly when trampolinists were looking at the trampoline bed before landing. In addition, there was a moderate correlation between the number of twists in a straight somersault and the variability accumulation at 75 % of the twist, highlighting that trampolinists accumulate more variability as the number of twist rotations increases.</div></div>","PeriodicalId":15168,"journal":{"name":"Journal of biomechanics","volume":"181 ","pages":"Article 112533"},"PeriodicalIF":2.4,"publicationDate":"2025-01-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143038534","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Difference in movement coordination and variability during Five-Repetition Sit-to-Stand between people with and without Chronic Low back pain","authors":"Dhananjaya Sutanto ,&nbsp;Cheuk Yin Ho ,&nbsp;Stephen H.S. Wong ,&nbsp;Adrian Pranata ,&nbsp;Yijian Yang","doi":"10.1016/j.jbiomech.2025.112531","DOIUrl":"10.1016/j.jbiomech.2025.112531","url":null,"abstract":"<div><div>Chronic low back pain (CLBP) affects people’s activities of daily living, including sitting down and standing up. Movement pattern analyses during five-repetition sit-to-stand (5RSTS) may allow CLBP status differentiation. 44 CLBP and 22 asymptomatic participants performed 5RSTS in this study, with their trunk and lower limb movements recorded using 3-dimensional motion capture system. Joint active range of motion, joint maximal velocity, joint and segment continuous relative phase (CRP) were analyzed. Mean absolute relative phase (MARP) and deviation phase (DP) variables were calculated in CRP analysis. Between-group kinematic variables were compared using One-way Multivariate Analysis of Covariance (MANCOVA). Significant variables from different methods were compared using binomial logistic regression to assess accuracy for CLBP status. Results showed that segmental CRP is the most sensitive method for CLBP assessment, with the CLBP group femur-to-pelvis and lumbar-to-pelvis movement coordination was more in-phase MARP (F(8,56) = 7.127, p &lt; 0.001, Wilks’Λ = 0.441, ηp² = 0.559) and stable DP (F(8,56) = 4.585, p &lt; 0.001, Wilks’Λ = 0.551, ηp² = 0.449) during both standing up and sitting down. Utilizing CRP variables yielded Nagelkerke R² = 0.708 and overall correct classification of 93 % for CLBP status. Individuals with CLBP exhibited distinct movement coordination and stability, which should be considered in CLBP assessments and intervention. Variable combination from the segment analysis was found to be the most predictive to CLBP status, and significantly different to the results obtained from joint analysis, highlighting the necessity for CRP method standardization in future studies.</div></div>","PeriodicalId":15168,"journal":{"name":"Journal of biomechanics","volume":"181 ","pages":"Article 112531"},"PeriodicalIF":2.4,"publicationDate":"2025-01-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143038951","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Increasing thigh extension with haptic feedback affects leg coordination in young and older adult walkers","authors":"Mohsen Alizadeh Noghani ,&nbsp;Ehsan Sharafian M. ,&nbsp;Ben Sidaway ,&nbsp;Babak Hejrati","doi":"10.1016/j.jbiomech.2025.112525","DOIUrl":"10.1016/j.jbiomech.2025.112525","url":null,"abstract":"<div><div>Interlimb coordination can be used as a metric to study the response of the neuromuscular system to mechanical perturbations and behavioral information. Behavioral information providing haptic feedback on thigh angle has been shown to increase stride length and consequently walking speed, but the effect of such feedback on limb coordination has not been determined. The current work investigates the effects of this feedback on lower-limb coordination and examines if such effects are dependent on the age of the walker. Existing kinematic data were examined from 10 young and 10 older adults during overground walking at self-selected normal and fast speeds and with thigh extension haptic feedback. Using sagittal angles of the lower-limb segments, we quantified changes in the mean of continuous relative phase (<span><math><mrow><mi>A</mi><mi>C</mi><mi>R</mi><mi>P</mi></mrow></math></span>) and its standard deviation (<span><math><mrow><mi>V</mi><mi>C</mi><mi>R</mi><mi>P</mi></mrow></math></span>) for thigh-shank and shank-foot segment pairs, over windows of 10% of gait cycle around peak thigh extension, toe-off, and heel strike. We found that the haptic feedback resulted in more in-phase movement (i.e., decreased <span><math><mrow><mi>A</mi><mi>C</mi><mi>R</mi><mi>P</mi></mrow></math></span>, Cohen’s <span><math><mi>d</mi></math></span>: 0.56-1.46), and larger coordination variability (i.e., increased <span><math><mrow><mi>V</mi><mi>C</mi><mi>R</mi><mi>P</mi></mrow></math></span>, Cohen’s <span><math><mi>d</mi></math></span>: 0.60-1.50) of the segment pairs across the three windows. Additionally, the young adults exhibited lower <span><math><mrow><mi>A</mi><mi>C</mi><mi>R</mi><mi>P</mi></mrow></math></span> than older adults (Cohen’s <span><math><mi>d</mi></math></span>=1.02) and higher <span><math><mrow><mi>V</mi><mi>C</mi><mi>R</mi><mi>P</mi></mrow></math></span> (Cohen’s <span><math><mi>d</mi></math></span>=1.02) when the feedback was provided. The results suggest that the haptic feedback elicited distinct adaptations in the neuromuscular system and that this response differed between young and older adults.</div></div>","PeriodicalId":15168,"journal":{"name":"Journal of biomechanics","volume":"181 ","pages":"Article 112525"},"PeriodicalIF":2.4,"publicationDate":"2025-01-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143028624","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bi-ventricular elastic material parameters estimation using 3D CMR myocardial strains in rheumatic heart disease patients","authors":"Mary A. Familusi ,&nbsp;Sebastian Skatulla ,&nbsp;Jagir R. Hussan ,&nbsp;Olukayode O. Aremu ,&nbsp;Stephen Jermy ,&nbsp;Daniel Mutithu ,&nbsp;Freedom N. Gumedze ,&nbsp;Ntobeko A.B. Ntusi","doi":"10.1016/j.jbiomech.2025.112524","DOIUrl":"10.1016/j.jbiomech.2025.112524","url":null,"abstract":"<div><div>Understanding the elastic material behavior of myocardium during the diastolic phase is critical for evaluating cardiac function and improving treatments for diastolic abnormalities. This study introduces a novel multi-objective optimization framework that incorporates both strain and volume measurements to enhance the accuracy of myocardial property assessments in Rheumatic Heart Disease (RHD) patients and healthy controls. By employing global volume and strain measurements instead of segmented strains from the sixteen AHA regions, we achieve a robust alignment with the Klotz curve across all groups, indicating an accurate simulation of end-diastolic pressure–volume relationships (EDPVRs). Our approach uniquely integrates combinations of longitudinal, circumferential, and radial strains, resulting in an unprecedented reduction in errors between clinical and simulated strain values, with less than one percent difference for targeted parameters. The results demonstrate that the alignment between computational predictions and clinical measurements depends significantly on the choice of optimization target. The study reveals significant differences in tissue mechanics between RHD patients and healthy controls, with notable variations in ventricular stiffness and fiber orientations across optimization targets, confirmed through rigorous statistical analyses. The observed variations in fiber angles, particularly the smaller angles for longitudinal strains and steeper angles for circumferential strains, underscore the intricate relationship between myocardial fiber architecture and cardiac deformation, offering deeper insights into ventricular biomechanics. By presenting qualitative and quantitative differences in stress and strain distributions, this research advances the understanding of myocardial mechanics, highlighting the clinical relevance of fiber orientation and material properties in modeling cardiac mechanics and distinguishing diseased from healthy myocardial behavior.</div></div>","PeriodicalId":15168,"journal":{"name":"Journal of biomechanics","volume":"181 ","pages":"Article 112524"},"PeriodicalIF":2.4,"publicationDate":"2025-01-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143023551","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Goal-equivalent drifts in sagittal joint angle configuration as indicators of optimality in postural alignment","authors":"Stephen M. Glass,&nbsp;Cameron G. Brummitt,&nbsp;Grant M. Westbrook,&nbsp;Adrian Aron","doi":"10.1016/j.jbiomech.2025.112526","DOIUrl":"10.1016/j.jbiomech.2025.112526","url":null,"abstract":"<div><div>The relevance of posture as a constituent of physical health varies depending on one’s explanatory framework of disease. Contrasting perspectives within this discussion refer to optimal biomechanics, but often without consistent meaning. The resulting theoretical confusion presents challenges both for applied research and clinical practice. We studied joint angle drift tendencies and sway-stabilizing synergy as indicators of optimality in relaxed bipedal standing. Sixteen subjects completed a series of 4-min bipedal standing trials under varying foot positions. Kinematic time series were segmented on the basis of multivariate changepoint location to quantify directional tendencies associated with slow, unintentional joint angle drifts. Subsequently, time series were segmented into shorter epochs and synergy indices describing center of mass stabilizing joint coordination were quantified for each epoch. Paired t-tests were used to assess the tendency of observed drifts to approximate common endpoints and “Random Effects Within Between” models were used to assess the relationship between synergy indices and Euclidean distance from individually defined drift targets. Our analyses suggest that 1) joint angles in relaxed bipedal standing tend to drift toward specific endpoints, and 2) greater deviation from these drift endpoints associates with greater COM-stabilizing coordinative synergy. We interpret these findings as supporting the presence of latent cost functions associated with individual sagittal joint angle configuration. We discuss our work in the context of the ongoing theoretical and clinical dialogue concerning optimal movement and the relevance of biomechanics in physical health.</div></div>","PeriodicalId":15168,"journal":{"name":"Journal of biomechanics","volume":"181 ","pages":"Article 112526"},"PeriodicalIF":2.4,"publicationDate":"2025-01-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143038504","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of a smartphone-based markerless system to measure lower-limb kinematics in patients with knee osteoarthritis","authors":"Junqing Wang ,&nbsp;Wei Xu ,&nbsp;Zhuoying Wu ,&nbsp;Hui Zhang ,&nbsp;Biao Wang ,&nbsp;Zongke Zhou ,&nbsp;Chen Wang ,&nbsp;Kang Li ,&nbsp;Yong Nie","doi":"10.1016/j.jbiomech.2025.112529","DOIUrl":"10.1016/j.jbiomech.2025.112529","url":null,"abstract":"<div><div>OpenCap, a smartphone-based markerless system, offers a cost-effective alternative to traditional marker-based systems for gait analysis. However, its kinematic measurement accuracy must be evaluated before widespread use in clinical practice. This study aimed to evaluate OpenCap for lower-limb joint angle measurements during walking in patients with knee osteoarthritis (OA) and to compare error metrics between patients and healthy controls. Lower-limb kinematic data were simultaneously collected from 53 patients with knee OA and 30 healthy individuals using OpenCap and a marker-based motion capture system while walking at a self-selected speed. Evaluation was assessed through root mean square error (RMSE) and intraclass correlation coefficient (ICC). Two-way repeated measures analyses of variance were employed to evaluate the main effects of and interactions between group (knee OA patients vs. healthy controls) and walking direction (toward vs. away from the camera). The results demonstrated a grand mean RMSE of 6.1° and an ICC of 0.67 for knee OA patients when walking toward the camera. Patients with knee OA exhibited significantly higher RMSE and lower ICC values compared to healthy controls. Additionally, walking toward the camera was associated with significantly lower RMSE and higher ICC values than walking away from the camera. OpenCap’s minimal hardware costs, free software, and user-friendly interface suggest its potential for widespread clinical implementation. The sagittal hip and knee angles demonstrate strong agreement with the marker-based system; however, caution is warranted in clinical decision-making for this population, as errors in most joint angles slightly surpass acceptable thresholds.</div></div>","PeriodicalId":15168,"journal":{"name":"Journal of biomechanics","volume":"181 ","pages":"Article 112529"},"PeriodicalIF":2.4,"publicationDate":"2025-01-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143038235","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}