Journal of biomechanics最新文献

{"title":"Knee functional calibration strengthens the relationship between lower limb bone morphology and hip rotation during gait","authors":"Morgan Sangeux ,&nbsp;Rodolphe Bailly ,&nbsp;Sylvain Brochard ,&nbsp;Mathieu Lempereur","doi":"10.1016/j.jbiomech.2025.112833","DOIUrl":"10.1016/j.jbiomech.2025.112833","url":null,"abstract":"<div><div>The position of the femur’s greater trochanter is crucial to produce the required hip abduction moment during gait. Clinical parameters describing the shape of the femur, such as femoral neck anteversion and neck shaft angles, influence the lever-arm of abductor muscles. In children with cerebral palsy, abnormal lower limb bone shapes may impair function, highlighting the importance of clinical gait analysis for surgical decision. Here, we re-examined a dataset on the correlation between 3D lower limb bony morphology and hip rotation kinematics during gait.</div><div>This study was a secondary analysis of a dataset from 121 children with cerebral palsy. 3D bony morphology was determined by a bi-planar, low dose, digital x-ray system and gait analysis utilised the conventional gait model with or without two functional knee calibration algorithms. The results indicated that functional calibration improved the variance explained by linear regression models between 3D bony morphology and the mean hip rotation during gait. Furthermore, femoral neck anteversion and neck shaft angles were now identified as significant predictors in the models. Despite differences between the functional algorithms, results of the associated regression models were similar.</div><div>However, bony morphology alone did not fully explain hip rotation, suggesting other factors are involved. We noted limitations in functional calibration due to soft tissue artifacts and insufficient knee range of movement. Previous results on the relationship between bony morphology and gait may be revisited considering the findings of this study.</div></div>","PeriodicalId":15168,"journal":{"name":"Journal of biomechanics","volume":"189 ","pages":"Article 112833"},"PeriodicalIF":2.4,"publicationDate":"2025-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144518525","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Validation of markerless (Theia3D™) against marker-based (Vicon™) motion capture data of postural control movements analyzed through principal component analysis","authors":"Peter Federolf,&nbsp;Mareike Kühne,&nbsp;Katharina Schiel,&nbsp;Elisa Reimeir,&nbsp;Daniel Debertin,&nbsp;Maité Calisti,&nbsp;Maurice Mohr","doi":"10.1016/j.jbiomech.2025.112831","DOIUrl":"10.1016/j.jbiomech.2025.112831","url":null,"abstract":"<div><div>Markerless motion capture systems, such as Theia3D, offer a promising alternative to traditional marker-based systems (e.g., Vicon) not only for dynamic motion analysis, but also potentially for postural control research. The purpose of this study is to simultaneously derive and then compare principal movements (PMs) from Theia3D and Vicon data collected from 13 volunteers during eyes-open and eyes-closed bipedal quiet stance using principal component analysis (PCA). Agreement between systems was assessed by computing correlation coefficients for corresponding PM time series and evaluating their sensitivity to visual condition changes. Theia3D and Vicon produced highly similar PM structures, with the first two PMs—representing anterior-posterior ankle-strategy and medio-lateral sway—exhibiting near-perfect correlation (r = 99.8 % and r = 99.0 %) and explaining a comparable portion of the entire postural variance (PM1: 74 % vs. 76 %; PM2: 9.4 % vs. 9.9 % for Vicon and Theia3D results, respectively). The first seven PMs, which collectively accounted for 97 % of postural variance, showed strong agreement (r = 0.814 to 0.928) despite fundamental differences in marker placement and tracking methodology. Correlation declined in higher-order PMs, suggesting they capture distinct aspects of postural movements or system-specific noise. Both systems demonstrated comparable sensitivity to postural control modulations induced by visual deprivation. Notably, Theia3D exhibited higher noise levels, particularly in higher-order PMs, indicating that pre-processing with filtering should be considered before PCA. Overall, these findings confirm that Theia3D provides highly comparable results to Vicon for postural PMs, reinforcing its potential as a valid and efficient alternative for postural control research using PCA-based approaches.</div></div>","PeriodicalId":15168,"journal":{"name":"Journal of biomechanics","volume":"189 ","pages":"Article 112831"},"PeriodicalIF":2.4,"publicationDate":"2025-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144518416","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Influence of bone material behavior assumption on finite element-predicted tibia-implant micromotions in total ankle replacement","authors":"Joshua E. Johnson ,&nbsp;Donald D. Anderson","doi":"10.1016/j.jbiomech.2025.112832","DOIUrl":"10.1016/j.jbiomech.2025.112832","url":null,"abstract":"<div><div>Initial tibial implant stability is important for successful long-term outcome after uncemented total ankle replacement (TAR). Tibia-implant interfacial micromotion is consequently a key variable used to evaluate implant performance using finite element analysis (FEA). Our goal was to investigate how bone material behavior assumptions influence FEA-predicted tibia-implant interfacial micromotions. Five tibia geometries and their corresponding density distributions were acquired from CT scans of TAR patients. The corresponding models were then virtually implanted with two tibial implant designs. FEA was used to simulate loadings from the stance phase of gait with line-to-line implantation. FEA predictions of peak micromotions and von Mises stress differences were compared across each patient-implant configuration, when incorporating elastic–plastic versus only linear elastic bone material behavior (5 tibias × 2 implant designs × 2 tibia material behaviors). We found that peak micromotions trended larger (up to 69 % greater) when elastic–plastic bone material behavior was incorporated, and that larger differences in peak micromotions were seen with larger differences in peak interfacial von Mises stresses between simulations incorporating elastic–plastic versus linear elastic bone material behavior (r = −0.73, p &lt; 0.001). The larger peak micromotions when elastic–plastic bone material behavior was incorporated were strongly associated with how much interfacial bone plasticly deformed (r = 0.92, p &lt; 0.001). These results imply that tibia-implant interfacial micromotions are underestimated when bone is assumed to behave only as a linear elastic material. Thus, the results from such FEA simulations should be interpreted with caution, as they are likely conservative in their estimates of micromotion.</div></div>","PeriodicalId":15168,"journal":{"name":"Journal of biomechanics","volume":"189 ","pages":"Article 112832"},"PeriodicalIF":2.4,"publicationDate":"2025-06-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144489843","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Age-related changes in gait coordination are focused on the step-to-step transition","authors":"Elham Alijanpour,&nbsp;Daniel M. Russell","doi":"10.1016/j.jbiomech.2025.112830","DOIUrl":"10.1016/j.jbiomech.2025.112830","url":null,"abstract":"<div><div>This study examined age-related changes in lower extremity coordination during gait using a unique gait phase normalization method, allowing time-continuous analysis while preserving phase-specific differences. Ten young and ten older healthy adults walked on an instrumented treadmill at their Preferred Walking Speed (PWS). Continuous Relative Phase (CRP) was used to assess intralimb and interlimb coordination and its variability across the gait cycle. Results showed that while older adults maintained largely similar coordination patterns to younger adults, significant differences emerged during transitions from double to single support. Specifically, older adults demonstrated altered hip-knee and interlimb knee coordination, driven by an earlier phase transition in knee phase angle during loading response and a delayed transition in hip phase angle during pre-swing. These alterations were accompanied by increased variability in interlimb hip coordination, particularly during critical gait transitions. Our findings suggest that age-related coordination changes are subtle and primarily affect step-to-step transitions. These changes may contribute to previously reported decreases in PWS, shorter step length, and increased metabolic cost in older adults. Future research should examine the relationship between these coordination changes and the age-related decline in PWS and increased metabolic cost of walking, as both are key consequences of altered step-to-step transitions.</div></div>","PeriodicalId":15168,"journal":{"name":"Journal of biomechanics","volume":"189 ","pages":"Article 112830"},"PeriodicalIF":2.4,"publicationDate":"2025-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144338995","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring the association between coronary vascular anatomical features and future myocardial infarction through statistical shape modelling","authors":"Bianca Griffo ,&nbsp;Maurizio Lodi Rizzini ,&nbsp;Alessandro Candreva ,&nbsp;Carlos Collet ,&nbsp;Takuya Mizukami ,&nbsp;Claudio Chiastra ,&nbsp;Diego Gallo ,&nbsp;Umberto Morbiducci ,&nbsp;Alessandra Aldieri","doi":"10.1016/j.jbiomech.2025.112829","DOIUrl":"10.1016/j.jbiomech.2025.112829","url":null,"abstract":"<div><div>Considering the intricate interplay among coronary anatomy and hemodynamics in coronary artery disease (CAD), anatomy-based descriptors have been employed as surrogates of local aberrant hemodynamics and, ultimately, as clinical markers for diagnostic and predictive purposes. However, anatomical descriptors have demonstrated unsatisfactory accuracy, making their further investigation cogent in CAD applications. Therefore, this study investigates the presence of unexplored pathological shape features of left anterior descending (LAD) coronary arteries associated with myocardial infarction (MI) at 5 years using statistical shape modelling. A statistical shape modelling framework combining principal component analysis (PCA) and linear discriminant analysis (LDA), where PCA outputs served as inputs to LDA, was applied to: (i) a cohort of 69 patient-specific LAD geometries, including both future culprit (FCL) and controls, <em>i.e.</em>, non-culprit lesions (NCL) of MI reconstructed from 3D quantitative coronary angiography; (ii) the same cohort after artificially removing the main lesion from each LAD model, aiming to isolate the contribution of the atherosclerotic burden beyond the main lesion severity, quantifiable using <span><math><mrow><mo>%</mo><mi>A</mi><mi>S</mi></mrow></math></span>. Using LDA, the hyperplane with significant discriminant capacity (p &lt; 0.0001) between NCL and FCL was identified for both cohorts. The combination of the statistical shape modelling-based representation accounting for the atherosclerotic burden exclusive of the main lesion severity with <span><math><mrow><mo>%</mo><mi>A</mi><mi>S</mi></mrow></math></span>, accounting explicitly for the main lesion severity, exhibited notable discrimination capacity for future MI. This study supports the hypothesis that the overall atherosclerotic burden may predispose to future MI and highlights the potential of a statistical shape modelling-based approach for integration into current imaging-driven clinical decision-making.</div></div>","PeriodicalId":15168,"journal":{"name":"Journal of biomechanics","volume":"189 ","pages":"Article 112829"},"PeriodicalIF":2.4,"publicationDate":"2025-06-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144365324","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ambulant children with cerebral palsy have similar leg muscle moment arms to typically developing children","authors":"Bart Bolsterlee ,&nbsp;Brian V.Y. Chow ,&nbsp;Catherine Morgan ,&nbsp;Iona Novak ,&nbsp;Caroline Rae ,&nbsp;Suzanne Davies ,&nbsp;Ann Lancaster ,&nbsp;Rodrigo R.N. Rizzo ,&nbsp;Claudia Y. Rizzo ,&nbsp;Robert D. Herbert","doi":"10.1016/j.jbiomech.2025.112828","DOIUrl":"10.1016/j.jbiomech.2025.112828","url":null,"abstract":"<div><div>Many children with cerebral palsy (CP) have muscle contractures and bony deformities. It has been hypothesised that these musculoskeletal abnormalities could increase or decrease muscle moment arms and cause movement dysfunction. In this study, we first investigated the relationship between skeletal growth (tibia length) and three-dimensional measurements of Achilles tendon and tibialis anterior moment arms from magnetic resonance images of 200 typically developing children aged 5 to 15 years. Moment arms increased linearly with tibia length. To determine whether cerebral palsy affects moment arms, we also measured Achilles tendon and tibialis anterior moment arms from a predominantly ambulant cohort of 79 children with CP (94% Gross Motor Function Classification System Level I or II). After adjusting for tibia length, age and sex, the Achilles tendon moment arms of children with cerebral palsy were, on average, slightly greater than those of typically developing children (mean difference 1.4 mm, 95% confidence interval (CI) 0.4 to 2.4; p &lt; 0.01) and tibialis anterior moment arms were slightly smaller (mean difference −0.9 mm, 95% CI −1.6 to −0.2, p &lt; 0.05). We conclude that moment arms scale linearly with tibia length during childhood development from 5 to 15 years. Ambulant children with cerebral palsy have moment arms that differ slightly, on average, from the moment arms of typically developing children, but those differences are too small to cause significant ankle joint dysfunction.</div></div>","PeriodicalId":15168,"journal":{"name":"Journal of biomechanics","volume":"189 ","pages":"Article 112828"},"PeriodicalIF":2.4,"publicationDate":"2025-06-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144330761","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrigendum to \"Novel arthrometer for quantitative clinical examination of the knee in three planes: Safety, reliability, minimum detectable changes, and side-to-side differences in healthy subjects\" [J. Biomech. 176 (2024) 112330].","authors":"Carl W Imhauser, Erin E Berube, Akinola Emmanuel Oladimeji, David Z Shamritsky, Zaid A Zayyad, Thomas J Fraychineaud, Jennifer T Vazquez, Hamidreza Jahandar, Stephen Lyman, Michael K Parides, Debi Jones, Theresa A Chiaia, Andrew D Pearle, Danyal H Nawabi, Thomas L Wickiewicz","doi":"10.1016/j.jbiomech.2025.112825","DOIUrl":"https://doi.org/10.1016/j.jbiomech.2025.112825","url":null,"abstract":"","PeriodicalId":15168,"journal":{"name":"Journal of biomechanics","volume":" ","pages":"112825"},"PeriodicalIF":2.4,"publicationDate":"2025-06-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144505814","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Experimental assessment of CO2 rebreathing in closed-circuit CPAP therapy with different non-invasive interfaces","authors":"Margherita De Luca ,&nbsp;Andrea Formaggio ,&nbsp;Mara Terzini ,&nbsp;Giovanni Putame ,&nbsp;Carlo Olivieri ,&nbsp;Simone Borrelli ,&nbsp;Alberto L. Audenino","doi":"10.1016/j.jbiomech.2025.112826","DOIUrl":"10.1016/j.jbiomech.2025.112826","url":null,"abstract":"<div><div>Continuous Positive Airway Pressure (CPAP) is a non-invasive ventilation therapy that supports respiratory function by improving functional residual capacity and maintaining open airways through positive pressure. Closed-circuit CPAP configurations are emerging as a promising alternative to conventional open circuits, offering several advantages. However, their effectiveness can be compromised by CO₂ rebreathing. This study aimed to quantify inhaled CO₂ levels during closed-circuit CPAP therapy with different interfaces and explore the effects of interface volume, inlet and outlet port position and airflow rates on CO₂ accumulation.</div><div>Four helmets, differing in port positioning, and One-port and Two-ports total-face Masks were tested under three flow conditions (0, 60, and 80 l/min) using an ad hoc test bench to measure CO₂ accumulation inside the interface.</div><div>Results demonstrated that interface design strongly influenced CO₂ retention. Lateral Inlet/Lateral Outlet Helmet (current commercial helmet) showed the highest inhaled CO₂ levels (about 2 %), while the Up Inlet/Front Outlet Helmet achieved lower inhaled CO₂ (0.6 % at 80 l/min). Masks, characterized by smaller volumes, consistently exhibited lower CO₂ retention. Notably, the Two-ports Mask maintained inhaled CO₂ levels below 1 % (patient safety threshold) even without additional recirculation airflow. Increasing flow rates effectively reduced CO₂ rebreathing, with the most pronounced reduction occurring between 0 and 60 l/min.</div><div>These findings highlight the critical role of interface design, particularly port positioning, in minimizing CO₂ rebreathing. The results enabled selection of safe interfaces for closed-circuit CPAP. Furthermore, these findings can be extended to conventional open-circuit CPAP therapy, enhancing patient safety in non-invasive ventilation.</div></div>","PeriodicalId":15168,"journal":{"name":"Journal of biomechanics","volume":"189 ","pages":"Article 112826"},"PeriodicalIF":2.4,"publicationDate":"2025-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144365321","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Predicting anterior tibial translations in pediatric ACL-deficient knees with finite element knee models","authors":"Alexandria Mallinos ,&nbsp;Kerwyn Jones","doi":"10.1016/j.jbiomech.2025.112821","DOIUrl":"10.1016/j.jbiomech.2025.112821","url":null,"abstract":"<div><div>Anterior cruciate ligament (ACL) injuries frequently occur in young individuals. However, knee biomechanics in this population, especially among adolescents, are poorly understood. The purpose of this study was to use finite element (FE) knee models to investigate anterior tibial translations during the Lachman test (LT) and pivot shift test (PST) in ACL-deficient pediatric knees. Computed tomography scans from 22 subjects (aged 9–18 years; 6 females, 16 males) were used to create FE knee models. Cadaveric, experimental data of ACL-deficient knees were used to validate the accuracy of the models’ anterior tibial displacement predictions. Simulated anterior tibial translations for the LT (21.2 mm at 134 N) and PST (7.0 mm) showed no significant differences from the experimental cadaver results (p = 0.37; p = 0.46), confirming model validity. Comparisons with ACL-intact, baseline models revealed significantly increased anterior tibial displacements in ACL-deficient knees under identical loading conditions (p &lt; 0.001), emphasizing the ACL’s stabilizing role in both translation and rotational mechanics. The study demonstrates the use of FE methods to simulate physiologically relevant pediatric knee biomechanics and highlights their potential as a preclinical tool for evaluating the biomechanical effects of surgical techniques and rehabilitation interventions. In doing so, this study provides insight into the development of personalized treatment strategies, further supporting clinical advancements in this understudied demographic.</div></div>","PeriodicalId":15168,"journal":{"name":"Journal of biomechanics","volume":"189 ","pages":"Article 112821"},"PeriodicalIF":2.4,"publicationDate":"2025-06-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144313275","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"In vivo-driven optimization of finite element models’ parameters for capturing altered mechanics in patients with Achilles tendinopathy","authors":"Alessia Funaro ,&nbsp;Vickie Shim ,&nbsp;Ine Mylle ,&nbsp;Chun Vong ,&nbsp;Benedicte Vanwanseele","doi":"10.1016/j.jbiomech.2025.112824","DOIUrl":"10.1016/j.jbiomech.2025.112824","url":null,"abstract":"<div><div>Patients with Achilles tendinopathy exhibit altered tendon mechanics, including changes in the sliding behaviour of Achilles tendon (AT) subtendons and variations in material properties. These individual mechanical alterations influence the AT’s response to load and the resulting strains, which are critical for understanding the mechanisms underlying Achilles tendinopathy and promoting effective recovery. The goal of this study was to develop an optimization routine to determine 1) patient-specific AT mechanics, representing the altered sliding mechanisms and 2) patient-specific material properties of the AT, thereby offering a more individualized depiction of the tendon’s response under load. Thirteen patients with Achilles tendinopathy were imaged at rest using three-dimensional freehand ultrasound. The images were manually segmented to create finite element models with patient-specific AT shapes, which also incorporated the twisted geometry of the subtendons. The optimization routine was informed by various <em>in vivo</em> experimental data, including AT elongations estimated during sub-maximal voluntary isometric contraction (measured via three-dimensional freehand ultrasound) for material coefficient estimation, as well as localized AT differential displacement (measured via ultrasound speckle tracking) for friction coefficient estimation. Additionally, patient-specific maximal voluntary isometric contraction (MVIC) force estimations were integrated into the model. This optimization process identified patient-specific material and friction coefficients for the finite element models, enabling the closest possible alignment with experimental observations. By incorporating altered tendon properties, such as subtendon sliding and material characteristics, the routine provides a tool for future applications which aim to gain a comprehensive understanding of the individualized AT response to load and offer valuable insights for managing Achilles tendinopathy.</div></div>","PeriodicalId":15168,"journal":{"name":"Journal of biomechanics","volume":"189 ","pages":"Article 112824"},"PeriodicalIF":2.4,"publicationDate":"2025-06-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144365355","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}