Journal of atherosclerosis and thrombosis最新文献

{"title":"Worksite Healthcare Systems and Lifestyle-related Risk Factors among Employees at Small-to-medium Worksites in Okinawa, Japan.","authors":"Shota Kudaka, Kenshu Taira, Atsushi Sakima, Koshi Nakamura","doi":"10.5551/jat.66257","DOIUrl":"https://doi.org/10.5551/jat.66257","url":null,"abstract":"<p><strong>Aim: </strong>To investigate whether the presence of common health education (HE) and a healthcare administrator (HA) at a worksite would be associated with a lower prevalence of current smoking, current daily alcohol consumption, and obesity among employees at real-world, small-to-medium worksites.</p><p><strong>Methods: </strong>The present cross-sectional study included 72,704 employees aged 35-59 years at 5,910 small-to-medium companies in Okinawa, Japan. Odds ratios were calculated by sex for each factor for HE (information provision alone, lecture classes alone, or both services) presence and HA presence, using a multilevel logistic regression model, with HE absence (neither) and HA absence, respectively, serving as the reference.</p><p><strong>Results: </strong>The odds ratios (95% confidence intervals) for current smoking among men and women in the combined HE services group were 0.80 (0.68-0.93) and 0.68 (0.52-0.88), respectively, after adjusting for age, HA status, medication status, and basic worksite characteristics. The adjusted odds ratios for current daily alcohol consumption among men and women in the combined HE services group were 0.81 (0.69-0.95) and 0.84 (0.69-1.02), respectively. However, the four HE groups had similar odds of obesity in both men and women. The HA-present and HA-absent groups had similar odds of all outcomes in both men and women, except that men in the HA-present group had lower odds of current daily alcohol consumption: 0.92 (0.86-0.98).</p><p><strong>Conclusions: </strong>The combined HE services presence was associated with lower odds of current smoking and daily alcohol consumption among employees, whereas HA presence was associated with lower odds of daily alcohol consumption among men.</p>","PeriodicalId":15128,"journal":{"name":"Journal of atherosclerosis and thrombosis","volume":" ","pages":""},"PeriodicalIF":3.4,"publicationDate":"2026-08-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148663870","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Literature Review on the Waist Circumference Criteria for Metabolic Syndrome in Japan: Evidence and Implications for Cardiovascular Risk Stratification.","authors":"Tomoe Uchida, Aya Hirata","doi":"10.5551/jat.RV22051","DOIUrl":"10.5551/jat.RV22051","url":null,"abstract":"<p><p>Waist circumference (WC) is widely used as a marker of central obesity in the diagnosis of metabolic syndrome (MetS) and it plays an important role in cardiovascular disease (CVD) risk screening. In Japan, the MetS diagnostic criteria established in 2005 require abdominal obesity as a mandatory component, with WC cutoff values of 85 cm for men and 90 cm for women. These criteria are also applied in the national Specific Health Checkup and Specific Health Guidance programs to identify individuals at a high risk of CVD. However, the scientific basis and clinical implications of these thresholds remain controversial.This review summarizes the epidemiological evidence on WC cutoff values in the Japanese population and their relevance to CVD risk. A literature search of PubMed and Ichushi-Web identified studies examining WC thresholds in relation to visceral fat accumulation, clustering of cardiometabolic risk factors, and incident CVD. The evidence was organized into four themes: (1) WC cutoffs based on visceral fat area, (2) prediction of cardiometabolic risk factor clustering, (3) the association between WC and incident CVD, and (4) associations between MetS definitions and CVD risk.Available evidence suggests that the WC thresholds corresponding to visceral fat accumulation and cardiometabolic risk clustering are generally lower than the current Japanese criterion for women. Prospective studies examining WC alone have reported inconsistent associations with incident CVD, particularly among women. Overall, the evidence suggests that CVD risk stratification frameworks requiring abdominal obesity based on WC thresholds may have limitations. Future screening strategies in Japan may benefit from greater emphasis on clustering and the overall burden of cardiometabolic risk factors.</p>","PeriodicalId":15128,"journal":{"name":"Journal of atherosclerosis and thrombosis","volume":" ","pages":"993-1014"},"PeriodicalIF":3.4,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13448046/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147963511","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Moving Toward Universal Risk Stratification: Globally Standardized Lipoprotein(a) in Molar Units.","authors":"Takashi Miida","doi":"10.5551/jat.ED309","DOIUrl":"10.5551/jat.ED309","url":null,"abstract":"","PeriodicalId":15128,"journal":{"name":"Journal of atherosclerosis and thrombosis","volume":" ","pages":"1028-1029"},"PeriodicalIF":3.4,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13447978/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148271552","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between cardiovascular disease risk factors and white matter lesions: The Tohoku Medical Megabank Cohort Study.","authors":"Megumi Satake, Ippei Chiba, Mana Kogure, Rieko Hatanaka, Kumi Nakaya, Masato Takase, Sayuri Tokioka, Naoki Nakaya, Naoko Mori, Takuya Koyama, Yuto Abe, Yasuyuki Taki, Nobuo Fuse, Kengo Kinoshita, Yoko Izumi, Shunji Mugikura, Atsushi Hozawa","doi":"10.5551/jat.65993","DOIUrl":"10.5551/jat.65993","url":null,"abstract":"<p><strong>Aim: </strong>White matter lesions (WML) are associated with dementia and they are influenced by cardiovascular disease (CVD) risk factors. Managing these risk factors may prevent WML progression. However, few longitudinal studies have examined the association between CVD risk factors and changes in the WML volume. This study aimed to investigate this association across a broad age range, including younger individuals.</p><p><strong>Methods: </strong>This longitudinal study included 4,595 participants (age range, 21-90 years; women, 61.7%) who underwent brain magnetic resonance imaging. WML was defined on T1-weighted images. The associations between each CVD risk factor (hypertension, diabetes, dyslipidemia, and current smoking) and WML volume changes (per 4 years) were analyzed using a generalized linear model with estimated regression coefficients (β) and 95% confidence intervals (CI). The analyses were stratified by age group (＜50, 50-59, 60-69, and ≥ 70 years).</p><p><strong>Results: </strong>Hypertension was significantly associated with increased WML volume change in those aged ＜50 and 50-59 years (β [95%CI] = 57.1 [8.0-106.2] and β [95%CI] = 77.9 [6.8-149.0], respectively). For both diabetes and dyslipidemia, the WML volume increased in those aged ＜50 years (β [95%CI] = 376.5 [209.3-543.8] and β [95%CI] = 154.0 [93.0-215.0], respectively). Current smoking showed an increase in those aged 50-59 and ≥ 60 years (β [95%CI] = 104.5 [2.1-206.8] and β [95%CI] = 305.9 [133.4-478.5], respectively). No significant associations were observed for any CVD risk factors in the other age groups.</p><p><strong>Conclusions: </strong>The WML volume changes were larger in younger age groups for most CVD risk factors, suggesting that early management of these factors may help prevent WML progression.</p>","PeriodicalId":15128,"journal":{"name":"Journal of atherosclerosis and thrombosis","volume":" ","pages":"1060-1082"},"PeriodicalIF":3.4,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13448049/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147772319","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Lipoprotein(a) Is Associated with Coronary Plaque Vulnerability and Compensatory Vascular Enlargement: An Intravascular Ultrasound Study.","authors":"Yufeng Jiang, Jie Lin, Mingyu Ma, Jiahong Xu, Pujiao Yu, Hairong Wang","doi":"10.5551/jat.66159","DOIUrl":"10.5551/jat.66159","url":null,"abstract":"<p><strong>Aims: </strong>Lipoprotein(a) [Lp(a)] has emerged as a critical determinant of residual cardiovascular risk. However, its impact on plaque morphology remains underinvestigated. This study aimed to elucidate the relationship between the serum Lp(a) levels, coronary plaque vulnerability, and vascular remodeling characteristics by utilizing intravascular ultrasound (IVUS).</p><p><strong>Methods: </strong>We retrospectively enrolled 292 consecutive patients with coronary artery disease who underwent IVUS. Target lesions were classified into vulnerable (n = 83) or stable (n = 209) plaque groups based on the IVUS criteria. Multivariate binary logistic regression was performed to identify independent predictors. The morphological parameters were further compared between the high (＞18.8 mg/dL) and low (≤ 18.8 mg/dL) Lp(a) groups.</p><p><strong>Results: </strong>The vulnerable plaque group exhibited significantly higher median serum Lp(a) levels than the stable group (14.56 vs. 11.04 mg/dL, P = 0.011). After adjusting for age, sex, LDL-C, smoking, diabetes, and hypertension, Lp(a) ＞18.8 mg/dL remained an independent predictor of plaque vulnerability (OR = 1.76; 95% CI: 1.00-3.07; P = 0.049). Notably, the LDL-C levels did not predict vulnerability in this cohort. Furthermore, the high Lp(a) group demonstrated significantly larger vascular dimensions (EEM CSA: 14.67±4.95 vs. 13.22±4.20 mm², P = 0.016) and plaque area (11.07±4.61 vs. 9.71±3.79 mm², P = 0.015) than the low Lp(a) group, consistent with compensatory vascular enlargement, although the difference in the remodeling index did not reach statistical significance.</p><p><strong>Conclusion: </strong>Elevated serum Lp(a) levels are independent predictors of coronary plaque vulnerability. The underlying mechanism involves Lp(a) promoting compensatory vascular enlargement, accompanied by an increased plaque volume. These findings underscore the necessity of Lp(a) screening to identify any residual risk, particularly in patients with effectively controlled low-density lipoprotein cholesterol (LDL-C).</p>","PeriodicalId":15128,"journal":{"name":"Journal of atherosclerosis and thrombosis","volume":" ","pages":"1083-1094"},"PeriodicalIF":3.4,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13448048/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147722960","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Two Sides of the Same Curve: Targets, Reduction, and LDL-C Burden.","authors":"Masatsune Ogura","doi":"10.5551/jat.ED311","DOIUrl":"10.5551/jat.ED311","url":null,"abstract":"","PeriodicalId":15128,"journal":{"name":"Journal of atherosclerosis and thrombosis","volume":" ","pages":"1025-1027"},"PeriodicalIF":3.4,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13447980/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148295246","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Lipoprotein(a) Distribution and Cardiovascular Risk in Japan: Insights from a Multi-center LEAP Study.","authors":"Tomoaki Yamada, Hayato Tada, Masatsune Ogura, Sayaka Funabashi, Hiroshi Yoshida, Chika Hiraishi, Takae Ebihara, Takahiro Hadano, Takahiro Masaki, Yasuaki Takeji, Kazumi Fukatsu, Makiko Egawa, Yu Kataoka, Masahito Michikura, Daisuke Shishikura, Shimpei Fujioka, Tetsuo Sasano, Taketoshi Maehara, Masumi Ai, Mariko Shiba-Harada, Masayuki Yoshida","doi":"10.5551/jat.66185","DOIUrl":"10.5551/jat.66185","url":null,"abstract":"<p><strong>Aim: </strong>Although lipoprotein(a) [Lp(a)] is recognized as an independent risk factor for cardiovascular disease (CVD), its distribution and risk thresholds in the Japanese population remain unclear. This study aimed to characterize the distribution of Lp(a) in Japanese clinical settings and evaluate its association with CVD risk, including coronary artery disease (CAD), atherosclerotic cardiovascular disease (ASCVD), and familial hypercholesterolemia (FH).</p><p><strong>Methods: </strong>The LEAP study is a multicenter retrospective cohort analysis of 6,173 patients from six Japanese institutions. The Lp(a) values were harmonized to nmol/L using kit-specific conversion equations, enabling a consistent analysis across different immunoassays. Associations with CAD, ASCVD, chronic kidney disease (CKD), diabetes mellitus (DM), and FH were assessed. The risk thresholds were defined using a receiver operating characteristic analysis.</p><p><strong>Results: </strong>The median Lp(a) concentration was 20.88 nmol/L, with a right-skewed distribution. Elevated Lp(a) levels were significantly associated with CAD, ASCVD, CKD, and FH. In contrast, DM was related to lower Lp(a). An ROC analysis identified 25 nmol/L as a screening threshold and 125 nmol/L as a high-risk boundary. The CAD prevalence increased stepwise across these categories: 20.2% (≤ 25 nmol/L), 30.3% (25-125 nmol/L), and 39.9% (＞125 nmol/L).</p><p><strong>Conclusion: </strong>This study provides the first nmol/L-standardized Lp(a) distribution in Japanese patients and proposes provisional thresholds for clinical risk stratification.</p>","PeriodicalId":15128,"journal":{"name":"Journal of atherosclerosis and thrombosis","volume":" ","pages":"1049-1059"},"PeriodicalIF":3.4,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13447981/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147838349","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of Relative LDL-Cholesterol Reduction With Cardiovascular Outcomes After Percutaneous Coronary Intervention.","authors":"Tetsuji Morishita, Hiroyasu Uzui, Yusuke Sato, Tomohiro Shimizu, Tatsuhiro Kataoka, Kanae Hasegawa, Hiroshi Tada","doi":"10.5551/jat.66182","DOIUrl":"10.5551/jat.66182","url":null,"abstract":"<p><strong>Aim: </strong>Intensive low-density lipoprotein cholesterol (LDL-C) lowering is a cornerstone of secondary prevention after percutaneous coronary intervention (PCI). Although most evidence has focused on achieved LDL-C levels, the prognostic significance of relative LDL-C reduction has been less well characterized. The joint influence of achieved LDL-C levels and relative reduction in real-world PCI populations remains unclear.</p><p><strong>Methods: </strong>We retrospectively analyzed consecutive patients who underwent PCI between 2006 and 2016 at a single tertiary center. Relative LDL-C reduction was calculated from baseline and follow-up measurements. The primary outcome was three-point major adverse cardiovascular events plus any coronary revascularization. Cox proportional hazards models with restricted cubic splines were used to assess continuous dose-response relationships. Secondary analyses evaluated categorical thresholds of relative LDL-C reduction (＜30%, 30-49%, ≥50%) and achieved LDL-C ＜55 mg/dL. A thin-plate spline generalized additive model was used to visualize their joint association with cardiovascular risk.</p><p><strong>Results: </strong>Among 809 patients, greater relative LDL-C reduction was associated with a significantly lower risk of the primary outcome in a nonlinear pattern (overall P = 0.0001; nonlinearity P = 0.0007). Compared with ＜30% reduction, 30-49% and ≥ 50% reductions were associated with progressively lower risk. Achieved LDL-C ＜55 mg/dL was associated with lower risk, and the most favorable outcomes were observed when low achieved LDL-C levels were accompanied by substantial relative LDL-C reduction.</p><p><strong>Conclusion: </strong>Relative LDL-C reduction provides clinically meaningful prognostic information after PCI, complementing achieved LDL-C levels and supporting guideline-based lipid-lowering strategies.</p>","PeriodicalId":15128,"journal":{"name":"Journal of atherosclerosis and thrombosis","volume":" ","pages":"1030-1048"},"PeriodicalIF":3.4,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13448047/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147772348","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Tortuosity of Middle Cerebral Artery is Associated with Ipsilateral Recurrence of Ischemic Events.","authors":"Yuan Chen, Yifan Wang, Yanan Zhu, Yue He, Tian Zhao, Jingwei Lin, Yuanwei Shao, Yeyin He, Yi Yang, Ying Zhu, Ming Yu","doi":"10.5551/jat.66176","DOIUrl":"10.5551/jat.66176","url":null,"abstract":"<p><strong>Aim: </strong>To investigate whether the tortuosity of the culprit middle cerebral artery (MCA) is correlated with the recurrence of ipsilateral ischemic events in patients with ischemic stroke caused by intracranial atherosclerotic disease (ICAD) on M₁ segment of MCA.</p><p><strong>Methods: </strong>A total of 279 patients with first-ever M₁-ICAD-related stroke were enrolled. The morphology of the culprit M₁ segment was measured using MR or CT angiography, including the arc and chord length. The tortuosity index was calculated as (arc length / chord length - 1) × 100%. During the follow-up, the primary endpoints included recurrent transient ischemic attack and ischemic stroke attributable to culprit M₁-ICAD. The participants were stratified into subgroups according to the tertiles of the tortuosity index: Q₁ (＜9.98%), Q₂ (9.98%-19.17%), and Q₃ (＞19.17%). Multivariate Cox regression was performed to identify the factors associated with recurrence and the recurrence rates of subgroups was analyzed by log-rank test.</p><p><strong>Results: </strong>The recurrence rates (group Q₁, 20.4%, group Q₂, 10.6%, group Q₃, 4.3%, p = 0.003) are statically different. The tortuosity index (HR[hazard ratios] = 0.96, 95% CI[confidence intervals] = 0.92-0.997, p = 0.037) is inversely associated with the recurrence. The Q₁ group exhibits a higher risk of recurrence (HR = 5.39, 95% CI: 1.66-17.48, p = 0.005) than the Q3 group, with the rate difference of 16.1% (95% CI: 6.9%-25.3%, p = 0.002).</p><p><strong>Conclusion: </strong>In patients with M₁-ICAD-related stroke, lower tortuosity index of culprit MCA is associated with a higher risk of recurrent ipsilateral ischemic events.</p>","PeriodicalId":15128,"journal":{"name":"Journal of atherosclerosis and thrombosis","volume":" ","pages":"1095-1109"},"PeriodicalIF":3.4,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13449047/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147772425","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Perspectives on Bempedoic Acid, ATP-citrate lyase inhibitor: Targeting Lipid Metabolism and Inflammation.","authors":"Ryuki Kitamoto, Yuki Morikawa-Isogai, Hitoshi Shimano","doi":"10.5551/jat.66057","DOIUrl":"10.5551/jat.66057","url":null,"abstract":"<p><p>Bempedoic acid is a novel oral low-density lipoprotein cholesterol (LDL-C)-lowering agent that selectively inhibits ATP-citrate lyase (ACL), an enzyme located upstream of 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase in the cholesterol biosynthesis pathway. Inhibition of ACL suppresses acetyl-CoA production, leading to reduced cholesterol synthesis and increased hepatic expression of LDL receptors, which lowers circulating LDL-C. Clinical trials have demonstrated an approximately 20% reduction in LDL-C when bempedoic acid is used in combination with statins. To offer a new perspective on the underlying mechanism, we reviewed the literature examining the LDL-C-lowering effects of bempedoic acid based on Michaelis-Menten kinetics. This framework helps explain why adding bempedoic acid to statin therapy may result in a synergistic increase in LDL-C reduction, greater than from increasing the statin dose alone. In animal studies, reductions observed in both hepatic and plasma triglyceride (TG) levels have been attributed to suppressed fatty acid synthesis due to decreased acetyl-CoA availability following ACL inhibition. Additionally, bempedoic acid has been shown to lower high-sensitivity C-reactive protein (hs-CRP) and inflammatory cytokines, suggesting potential anti-inflammatory and anti-lipotoxic effects. These findings support broader metabolic benefits of bempedoic acid, particularly in conditions such as obesity and fatty liver with hypercholesterolemia. In this review article, we outline the synergistic effects of bempedoic acid with statins, and its potential metabolic benefits based on the mechanism of action of bempedoic acid, and discuss its prospective role in future lipid management strategies.</p>","PeriodicalId":15128,"journal":{"name":"Journal of atherosclerosis and thrombosis","volume":" ","pages":"1015-1024"},"PeriodicalIF":3.4,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13447979/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148015708","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}