Sex Differences Regarding the Risk of Incident Venous Thromboembolism in Hospitalized Patients with an Acute Exacerbation of Chronic Obstructive Pulmonary Disease.

IF 3 2区医学 Q2 PERIPHERAL VASCULAR DISEASE

Journal of atherosclerosis and thrombosis Pub Date : 2025-04-02 DOI:10.5551/jat.65451

Jiaqi Pu, Qun Yi, Yuanming Luo, Hailong Wei, Huiqing Ge, Huiguo Liu, Jianchu Zhang, Xianhua Li, Pinhua Pan, XiuFang Xie, Mengqiu Yi, Lina Cheng, Hui Zhou, Jiarui Zhang, Lige Peng, Jiaxin Zeng, Xueqing Chen, Haixia Zhou

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Abstract

Aims: Sex differences in the risk of venous thromboembolism (VTE) among patients with an acute exacerbation of chronic obstructive pulmonary disease (AECOPD) have so far only been sparsely described. This study aimed to investigate the differences in the risk of VTE events between male and female AECOPD patients and to determine whether any specific risk factors for VTE vary between the sexes.

Methods: We prospectively enrolled patients hospitalized for AECOPD from ten medical centers in China. The primary outcome was the occurrence of VTE. Univariate and multivariate logistic regression analyses were conducted to determine whether sex was an independent risk factor for VTE and also to identify any sex-specific risk factors.

Results: In total, 13,664 patients were included. VTE occurred in 5.5% of females and 3.3% of males (P＜0.001). A multivariate logistic regression analysis identified female sex as an independent risk factor for VTE in patients with AECOPD (odds ratio [OR] = 1.439, 95% confidence interval [CI] = 1.177-1.759, P＜0.001) after adjusting for confounding factors. Common risk factors for both sexes included age, chronic heart failure, severe lung disease, stroke, a recent surgical history, a history of VTE, and respiratory failure. Additional risk factors unique to males were sepsis (OR = 9.514, 95% CI = 4.513-20.056, P＜0.001), varicose veins (OR = 6.170, 95% CI = 3.237-11.763, P＜0.001), and rheumatological disorders (OR = 2.677, 95% CI = 1.184-6.052, P = 0.018). No sex-specific risk factors were identified for females.

Conclusion: Female sex was found to be an independent risk factor for VTE and some sex-specific risk factors exist among inpatients with AECOPD. These findings highlight the importance of considering sex and sex-related factors when assessing the VTE risk in AECOPD patients.

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慢性阻塞性肺疾病急性加重住院患者发生静脉血栓栓塞风险的性别差异

目的：迄今为止，慢性阻塞性肺疾病（AECOPD）急性加重期患者静脉血栓栓塞（VTE）风险的性别差异只有很少的描述。本研究旨在探讨男性和女性AECOPD患者静脉血栓栓塞事件发生风险的差异，并确定静脉血栓栓塞的特定危险因素是否存在性别差异。方法：我们前瞻性地纳入了来自中国10个医疗中心的AECOPD住院患者。主要结局是静脉血栓栓塞的发生。进行单因素和多因素logistic回归分析，以确定性别是否是静脉血栓栓塞的独立危险因素，并确定任何性别特异性的危险因素。结果：共纳入13664例患者。静脉血栓栓塞发生率女性为5.5%，男性为3.3% （P<0.001）。多因素logistic回归分析发现，女性性别是AECOPD患者静脉血栓栓塞的独立危险因素（优势比[OR] = 1.439, 95%可信区间[CI] = 1.177-1.759， P<0.001）。男性和女性的常见危险因素包括年龄、慢性心力衰竭、严重肺部疾病、中风、近期手术史、静脉血栓栓塞史和呼吸衰竭。男性特有的其他危险因素有脓毒症（OR = 9.514, 95% CI = 4.513-20.056， P<0.001）、静脉曲张（OR = 6.170, 95% CI = 3.237-11.763， P<0.001）和风湿病（OR = 2.677, 95% CI = 1.184-6.052, P = 0.018）。在女性中没有发现特定性别的危险因素。结论：女性是静脉血栓栓塞的独立危险因素，AECOPD住院患者存在一些性别特异性的危险因素。这些发现强调了在评估AECOPD患者静脉血栓栓塞风险时考虑性别和性别相关因素的重要性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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