Journal of Cancer Prevention最新文献_第7页

Various Forms of Silicon Electronic Waste and Predisposition to Cancer. 各种形式的硅电子废物和癌症易感性。

IF 2.5

Journal of Cancer Prevention Pub Date : 2023-03-30 DOI: 10.15430/JCP.2023.28.1.1

Nilesh Kumar Sharma, Sachin Chakradhar Sarode

引用次数: 0

A Genomic Approach to Identify the Different between Acute and Chronic UVB Exposures in the Causation of Inflammation and Cancer. 用基因组方法鉴定急性和慢性UVB暴露在炎症和癌症病因中的差异。

IF 2.5

Journal of Cancer Prevention Pub Date : 2022-12-31 DOI: 10.15430/JCP.2022.27.4.199

JunPyo Han, Yujin Jang, Dong Yeop Shin, Jun Lee, Young Rok Seo

{"title":"A Genomic Approach to Identify the Different between Acute and Chronic UVB Exposures in the Causation of Inflammation and Cancer.","authors":"JunPyo Han, Yujin Jang, Dong Yeop Shin, Jun Lee, Young Rok Seo","doi":"10.15430/JCP.2022.27.4.199","DOIUrl":"https://doi.org/10.15430/JCP.2022.27.4.199","url":null,"abstract":"As a principal component of solar radiation, ultraviolet B (UVB) exposure can be harmful depending on the duration and intensity because the human body can easily be exposed to it. Many studies have demonstrated that UVB causes a series of inflammatory and other skin disorders. UVB has been classified as the Group 1 carcinogen by the International Agency for Research on Cancer. Diverse studies have focused on UVB exposure but the complex perspective of acute and chronic UVB exposure is still lacking. This review presents the differences between acute and chronic exposure to UVB and summarizes public information in terms of toxicogenomic characteristics. We also demonstrated the differences between adverse effects of acute and chronic UVB exposure on the skin system. From the published literatures, we compared the biological pathways predict of the adverse effects caused by each UVB exposure type. Furthermore, our review not only clarifies the differences in each UVB exposure network but also suggests major hub genes related to cellular mechanisms and diseases that are thought to be affected by acute and chronic UVB exposure.","PeriodicalId":15120,"journal":{"name":"Journal of Cancer Prevention","volume":"27 4","pages":"199-207"},"PeriodicalIF":2.5,"publicationDate":"2022-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/28/39/jcp-27-4-199.PMC9836911.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9262033","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cedrol, a Sesquiterpene Isolated from Juniperus chinensis, Inhibits Human Colorectal Tumor Growth associated through Downregulation of Minichromosome Maintenance Proteins. 雪松醇是一种从中国杜松中分离的倍半萜，通过下调微染色体维持蛋白抑制人结直肠癌的生长。

IF 2.5

Journal of Cancer Prevention Pub Date : 2022-12-31 DOI: 10.15430/JCP.2022.27.4.221

Soojung Jin, Jung-Ha Park, Hee Jung Yun, You Na Oh, Seunghye Oh, Yung Hyun Choi, Byung Woo Kim, Hyun Ju Kwon

{"title":"Cedrol, a Sesquiterpene Isolated from Juniperus chinensis, Inhibits Human Colorectal Tumor Growth associated through Downregulation of Minichromosome Maintenance Proteins.","authors":"Soojung Jin, Jung-Ha Park, Hee Jung Yun, You Na Oh, Seunghye Oh, Yung Hyun Choi, Byung Woo Kim, Hyun Ju Kwon","doi":"10.15430/JCP.2022.27.4.221","DOIUrl":"https://doi.org/10.15430/JCP.2022.27.4.221","url":null,"abstract":"Cedrol, a sesquiterpene alcohol, isolated from Juniperus chinensis has been reported to inhibit minichromosome maintenance (MCM) proteins as cancer biomarkers in human lung cancer in vitro. In the present study, we investigated the anti-cancer activity of cedrol in vitro and in vivo using human colorectal cancer HT29 cells and a human colorectal tumor xenograft model. Cedrol inhibited MCM protein expression and cell growth in HT29 cells, which are associated with G1 arrest and the induction of apoptosis. We demonstrated that cedrol effectively reduced HT29 tumor growth without apparent weight loss in a human tumor xenograft model. Compared with vehicle- and adriamycin-treated tumor tissues, cedrol induced changes in the tumor tissue structure, resulting in a reduced cell density within the tumor parenchyma and reduced vascularization. Moreover, the expression of MCM7, an important subunit of MCM helicase, was significantly suppressed by cedrol in tumor tissue. Collectively, these results suggest that cedrol may act as a potential anti-cancer agent for colorectal cancer by inhibiting MCM protein expression and tumor growth.","PeriodicalId":15120,"journal":{"name":"Journal of Cancer Prevention","volume":"27 4","pages":"221-228"},"PeriodicalIF":2.5,"publicationDate":"2022-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/d4/ff/jcp-27-4-221.PMC9836914.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10127882","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Effects of Sangju Honey on Oral Squamous Carcinoma Cells. 桑菊蜂蜜对口腔鳞癌细胞的影响。

IF 2.5

Journal of Cancer Prevention Pub Date : 2022-12-31 DOI: 10.15430/JCP.2022.27.4.239

Nangwon Yee, Hyeonjin Kim, Eungyung Kim, Yong Ho Cha, Lei Ma, Na Eun Cho, Dongwook Kim, Chae Yeon Kim, Sung-Hyun Kim, Zaeyoung Ryoo, Junkoo Yi, Myoung Ok Kim

{"title":"Effects of Sangju Honey on Oral Squamous Carcinoma Cells.","authors":"Nangwon Yee, Hyeonjin Kim, Eungyung Kim, Yong Ho Cha, Lei Ma, Na Eun Cho, Dongwook Kim, Chae Yeon Kim, Sung-Hyun Kim, Zaeyoung Ryoo, Junkoo Yi, Myoung Ok Kim","doi":"10.15430/JCP.2022.27.4.239","DOIUrl":"https://doi.org/10.15430/JCP.2022.27.4.239","url":null,"abstract":"Since ancient times, honey has been used in traditional medicine owing to its pharmacological effects. It possesses anticancer properties. However, the therapeutic implications of Sangju honey in cancer remains unknown. Therefore, we aimed to demonstrate the potential anticancer effects of Sangju honey on human oral squamous cell carcinoma (OSCC), particularly focusing on epithelial-mesenchymal transition (EMT) and apoptotic and mitogen-activated protein kinase (MAPK) signaling pathways. Ca9-22 and YD-10B human OSCC cells were treated with 0.25% or 0.5% Sangju honey, and the cell viability was examined using the Cell Counting Kit-8 assay. Cell morphology studies were conducted to observe morphological changes, and the wound-healing assay was performed to evaluate the proliferation of honey-treated OSCC cells. Western blot analysis was conducted to investigate protein expression related to EMT and apoptotic and MAPK signaling pathways. Sangju honey reduced cell viability, induced morphological changes, and significantly suppressed the proliferation and migration of Ca9-22 and YD-10B cells. The expression of E-cadherin and N-cadherin was increased and decreased, respectively, in both OSCC cell lines. Moreover, Sangju honey stimulated apoptosis by increasing the expression of p21, p53, cleaved caspase 3, and caspase 9. Furthermore, it downregulated the expression of phospho (p)-extracellular signal-regulated kinases 1 and 2, p-c-Jun amino-terminal kinase, and p-p38 in Ca9-22 and YD-10B cells. Sangju honey inhibits Ca9-22 and YD-10B cell proliferation by regulating EMT, inducing apoptosis, and suppressing the MAPK signaling pathway. Thus, it is a potential anticancer agent for human OSCC.","PeriodicalId":15120,"journal":{"name":"Journal of Cancer Prevention","volume":"27 4","pages":"239-246"},"PeriodicalIF":2.5,"publicationDate":"2022-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/d5/61/jcp-27-4-239.PMC9836912.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10640690","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Association between Diet-related Behaviour and Risk of Colorectal Cancer: A Scoping Review. 饮食相关行为与结直肠癌风险之间的关系：一项范围综述

IF 2.5

Journal of Cancer Prevention Pub Date : 2022-12-31 DOI: 10.15430/JCP.2022.27.4.208

Nur Mahirah Amani Binti Mohammad, Mohd Razif Shahril, Suzana Shahar, Michael Fenech, Razinah Sharif

{"title":"Association between Diet-related Behaviour and Risk of Colorectal Cancer: A Scoping Review.","authors":"Nur Mahirah Amani Binti Mohammad, Mohd Razif Shahril, Suzana Shahar, Michael Fenech, Razinah Sharif","doi":"10.15430/JCP.2022.27.4.208","DOIUrl":"10.15430/JCP.2022.27.4.208","url":null,"abstract":"Individual dietary patterns may be influenced by diet-related behaviours, which may eventually play a significant role in contributing to colorectal cancer risk. As nearly half of colorectal cancer cases can be prevented through diet and lifestyle modification, in this study, we aimed to present an overview of the literature on diet-related behaviour and its effect on colorectal cancer risk among adults. Articles published from 2011 until July 2021 were selected. Out of the 1,198 articles retrieved, 25 were analyzed. There were 16 case-control studies, and nine of them were cohort studies. As a finding, the instruments used in this review were food frequency questionnaires (n = 23), followed by a semi-structured interview (n = 1), and diet records (n = 1). We demonstrated that unhealthy diet-related behaviours are linked to an increased risk of colorectal cancer in adults and those food frequency questionnaires or food records are common instruments used to collect diet-related behaviours. This article imparts the research trends and directions of colorectal cancer risk factors and shows that diet-related behaviour varies and changes over time.","PeriodicalId":15120,"journal":{"name":"Journal of Cancer Prevention","volume":"27 4","pages":"208-220"},"PeriodicalIF":2.5,"publicationDate":"2022-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/d1/db/jcp-27-4-208.PMC9836915.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10640695","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Consumption of Coffee and Green Tea and the Risk of Colorectal Cancer in Korea: The Health Examinees Study. 韩国人饮用咖啡和绿茶与结直肠癌的风险:健康体检者研究

IF 2.5

Journal of Cancer Prevention Pub Date : 2022-12-31 DOI: 10.15430/JCP.2022.27.4.229

Hyuntak Na, Jeeyoo Lee, Sooyoung Cho, Woo-Kyoung Shin, Ji-Yeob Choi, Daehee Kang, Aesun Shin

{"title":"Consumption of Coffee and Green Tea and the Risk of Colorectal Cancer in Korea: The Health Examinees Study.","authors":"Hyuntak Na, Jeeyoo Lee, Sooyoung Cho, Woo-Kyoung Shin, Ji-Yeob Choi, Daehee Kang, Aesun Shin","doi":"10.15430/JCP.2022.27.4.229","DOIUrl":"https://doi.org/10.15430/JCP.2022.27.4.229","url":null,"abstract":"Coffee and green tea may affect colorectal physiology and contain many bioactive components, such as polyphenol and caffeine, which have antioxidant and anti-carcinogenic activities. However, the association between coffee and green tea consumption and the risk of colorectal cancer (CRC) has been inconclusive. This study examined the association between coffee and green tea consumption and the risk of CRC in a large-scale prospective cohort study in Korea. Data from the Health Examinees study from 2004 to 2013 were analyzed, and 114,243 participants (39,380 men and 74,863 women) aged 40-79 years were included in the final analysis. A Cox proportional hazards regression model using age at time scale was used to estimate hazard ratios (HRs) and 95% confidence intervals (CIs) of coffee and green tea consumption for the risk of CRC by sex. In both men and women, no significant association was found between coffee and green tea consumption and the risk of CRC. Among women, there was a significant increase in the risk of colon cancer (HR, 1.66; 95% CI, 1.13-2.44) in the black coffee drinker group. Our findings suggest that consumption of coffee and green tea may not be associated with the CRC incidence in Korea; instead, the association may differ depending on cancer subsites and coffee types.","PeriodicalId":15120,"journal":{"name":"Journal of Cancer Prevention","volume":"27 4","pages":"229-238"},"PeriodicalIF":2.5,"publicationDate":"2022-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/6f/a4/jcp-27-4-229.PMC9836913.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10640693","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Deep Learning Architecture for Meningioma Brain Tumor Detection and Segmentation. 脑膜瘤检测与分割的深度学习架构。

IF 2.5

Journal of Cancer Prevention Pub Date : 2022-09-30 DOI: 10.15430/JCP.2022.27.3.192

John Nisha Anita, Sujatha Kumaran

{"title":"A Deep Learning Architecture for Meningioma Brain Tumor Detection and Segmentation.","authors":"John Nisha Anita, Sujatha Kumaran","doi":"10.15430/JCP.2022.27.3.192","DOIUrl":"https://doi.org/10.15430/JCP.2022.27.3.192","url":null,"abstract":"The meningioma brain tumor detection and segmentation method is a complex process due to its low intensity pixel profile. In this article, the meningioma brain tumor images were detected and tumor regions were segmented using a convolutional neural network (CNN) classification approach. The source brain MRI images were decomposed using the discrete wavelet transform and these decomposed sub bands were fused using an arithmetic fusion technique. The fused image was data augmented in order to increase the sample size. The data augmented images were classified into either healthy or malignant using a CNN classifier. Then, the tumor region in the classified meningioma brain image was segmented using an connection component analysis algorithm. The tumor region segmented meningioma brain image was compressed using a lossless compression technique. The proposed method stated in this article was experimentally tested with the sets of meningioma brain images from an open access dataset. The experimental results were compared with existing methods in terms of sensitivity, specificity and tumor segmentation accuracy.","PeriodicalId":15120,"journal":{"name":"Journal of Cancer Prevention","volume":"27 3","pages":"192-198"},"PeriodicalIF":2.5,"publicationDate":"2022-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/26/b2/jcp-27-3-192.PMC9537580.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40340013","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Role of Post-translational Modification of Silent Mating Type Information Regulator 2 Homolog 1 in Cancer and Other Disorders. 沉默交配型信息调控因子2同源物1翻译后修饰在癌症和其他疾病中的作用。

IF 2.5

Journal of Cancer Prevention Pub Date : 2022-09-30 DOI: 10.15430/JCP.2022.27.3.157

Yeon-Hwa Lee, Su-Jung Kim, Young-Joon Surh

引用次数: 0

Vitamin D and Colorectal Cancer: Current Perspectives and Future Directions. 维生素D与结直肠癌:目前的观点和未来的方向。

IF 2.5

Journal of Cancer Prevention Pub Date : 2022-09-30 DOI: 10.15430/JCP.2022.27.3.147

Soo-Young Na, Ki Bae Kim, Yun Jeong Lim, Hyun Joo Song

{"title":"Vitamin D and Colorectal Cancer: Current Perspectives and Future Directions.","authors":"Soo-Young Na, Ki Bae Kim, Yun Jeong Lim, Hyun Joo Song","doi":"10.15430/JCP.2022.27.3.147","DOIUrl":"https://doi.org/10.15430/JCP.2022.27.3.147","url":null,"abstract":"Vitamin D is considered to be the main mediator of the beneficial effects of sun exposure. In humans, highest expression of Vitamin D receptors is found in the intestinal tract. In addition, 1α,25-dihydroxyvitamin D3 (or calcitriol), the most active Vitamin D metabolite, plays important homeostatic roles in the intestine, particularly calcium absorption. Vitamin D deficiency is defined as a serum 25-hydroxyvitamin D [25(OH)D] level of < 20 ng/mL. Previous studies show that higher circulating 25(OH)D levels are associated with reduced risk of colorectal cancer (CRC) and improved survival. Most research to date has been conducted in animals, specifically mice. Although human studies have a limited number of participants, one study recruiting a large cohort of patients with advanced or metastatic CRC revealed that higher plasma 25(OH)D levels are associated with improved overall and progression-free survival. However, the effects of Vitamin D supplementation on incidence and mortality of CRC remain inconclusive. Although Vitamin D may help to prevent cancer, there is a paucity of research demonstrating conclusively that Vitamin D alters prognosis after chemotherapy. Here, we review the mechanisms by which Vitamin D affects CRC, as well as the results of clinical, epidemiological, and human intervention studies. We also discuss current perspectives and future directions regarding Vitamin D and CRC.","PeriodicalId":15120,"journal":{"name":"Journal of Cancer Prevention","volume":"27 3","pages":"147-156"},"PeriodicalIF":2.5,"publicationDate":"2022-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/07/6e/jcp-27-3-147.PMC9537583.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40340014","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

Silibinin Radiosensitizes EGF Receptor-knockdown Prostate Cancer Cells by Attenuating DNA Repair Pathways. 水飞蓟宾通过减弱DNA修复途径使EGF受体下调的前列腺癌细胞放射增敏。

IF 2.5

Journal of Cancer Prevention Pub Date : 2022-09-30 DOI: 10.15430/JCP.2022.27.3.170

Mohit Rajput, Deepali Mishra, Kunal Kumar, Rana P Singh

{"title":"Silibinin Radiosensitizes EGF Receptor-knockdown Prostate Cancer Cells by Attenuating DNA Repair Pathways.","authors":"Mohit Rajput, Deepali Mishra, Kunal Kumar, Rana P Singh","doi":"10.15430/JCP.2022.27.3.170","DOIUrl":"https://doi.org/10.15430/JCP.2022.27.3.170","url":null,"abstract":"Emergence of radioresistance in prostate cancer (PCa) cells is a major obstacle in cancer therapy and contributes to the relapse of the disease. EGF receptor (EGFR) signaling plays an important role in the development of radioresistance. Herein, we have assessed the modulatory effects of silibinin on radiation-induced resistance via DNA repair pathways in EGFR-knockdown DU145 cells. shRNA-based silencing of EGFR was done in radioresistant human PCa DU145 cells and effects of ionizing radiation (IR) and silibinin were assessed using clonogenic and trypan blue assays. Furthermore, radiosensitizing effects of silibinin on PCa in context with EGFR were analyzed using flow cytometry, comet assay, and immunoblotting. Silibinin decreased the colony formation ability with an increased death of DU145 cells exposed to IR (5 Gray), with a concomitant decrease in Rad51 protein expression. Silibinin (25 μM) augmented the IR-induced cytotoxic effect in EGFR-knockdown PCa cells, along with induction of G2/M phase cell cycle arrest. Further, we studied homologous recombination (HR) and non-homologous end joining (NHEJ) pathways in silibinin-induced DNA double-strand breaks in EGFR-knockdown DU145 cells. Silibinin down-regulated the expression of Rad51 and DNA-dependent protein kinase proteins without any considerable effect on Ku70 and Ku80 in IR-exposed EGFR-knockdown PCa cells. The pro-survival signaling proteins, phospho-extracellular signal-regulated kinases (ERK)1/2, phospho-Akt and phospho-STAT3 were decreased by silibinin in EGFR-deficient PCa cells. These findings suggest a novel mechanism of silibinin-induced radiosensitization of PCa cells by targeting DNA repair pathways, HR and NHEJ, and suppressing the pro-survival signaling pathways, ERK1/2, Akt and STAT3, in EGFR-knockdown PCa cells.","PeriodicalId":15120,"journal":{"name":"Journal of Cancer Prevention","volume":"27 3","pages":"170-181"},"PeriodicalIF":2.5,"publicationDate":"2022-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/fa/2c/jcp-27-3-170.PMC9537578.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40340015","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1