Journal of Cancer Prevention最新文献

"It's Not Just Cost": Barriers to Mammography Screening Access Among Low-income Women in the United States-A Scoping Review. “不仅仅是成本问题”：美国低收入妇女获得乳房x光检查的障碍——一项范围审查。

IF 2.5

Journal of Cancer Prevention Pub Date : 2026-07-30 Epub Date: 2026-06-16 DOI: 10.15430/JCP.26.013

Julia Messerman, Callia Nickels, Nigel James

{"title":"\"It's Not Just Cost\": Barriers to Mammography Screening Access Among Low-income Women in the United States-A Scoping Review.","authors":"Julia Messerman, Callia Nickels, Nigel James","doi":"10.15430/JCP.26.013","DOIUrl":"10.15430/JCP.26.013","url":null,"abstract":"Despite the recognized importance of early detection, disparities in mammography access persist among low-income women in the United States. While financial barriers are often emphasized, less is known about how multiple barriers interact to shape access to screening. We conducted a scoping review following Preferred Reporting Items for Systematic Reviews and Meta-Analyses Extension for Scoping Reviews guidelines to synthesize evidence on barriers to mammography access among low-income women in the United States. A systematic search of PubMed, CINAHL, and Google Scholar identified peer-reviewed studies published between 2010 and 2025, of which 47 met inclusion criteria. Extracted barriers were categorized into five domains: financial, structural, informational, cultural/social, and systemic. Barriers were multidimensional and frequently co-occurred across domains. Structural barriers, including transportation challenges and limited clinic availability, were the most reported, followed by financial and informational constraints. Cultural factors such as fear, stigma, and mistrust, along with systemic issues including provider bias and fragmented care coordination, further constrained access. Across studies, barriers rarely operated in isolation but instead reinforced one another, producing layered disadvantage that limited both screening uptake and follow-up care. These findings highlight the need for integrated, multi-level interventions that address structural, informational, and systemic barriers simultaneously. Expanding insurance coverage alone is insufficient; improving access will require strengthening patient navigation, enhancing care coordination, and embedding culturally responsive approaches within health systems.","PeriodicalId":15120,"journal":{"name":"Journal of Cancer Prevention","volume":"31 3","pages":"107-115"},"PeriodicalIF":2.5,"publicationDate":"2026-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13423739/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148653946","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Protective Potential of Terpenoid-Rich Canarium odontophyllum Miq. Leaves against 7,12-Dimethylbenz[a]anthracene and Ultraviolet B-induced Two-stage Skin Carcinogenesis in BALB/c Mice. 富含萜类化合物的齿形Canarium dontophyum Miq的保护作用。叶片抗7,12-二甲基苯[a]蒽和紫外线b诱导的BALB/c小鼠两期皮肤癌

IF 2.5

Journal of Cancer Prevention Pub Date : 2026-07-30 DOI: 10.15430/JCP.26.015

Muhammad Wahizul Haswan Abdul Aziz, Raveena Vaidheswary Muralitharan, Dayang Fredalina Basri, Siti Fathiah Masre, Ahmad Rohi Ghazali

{"title":"The Protective Potential of Terpenoid-Rich Canarium odontophyllum Miq. Leaves against 7,12-Dimethylbenz[a]anthracene and Ultraviolet B-induced Two-stage Skin Carcinogenesis in BALB/c Mice.","authors":"Muhammad Wahizul Haswan Abdul Aziz, Raveena Vaidheswary Muralitharan, Dayang Fredalina Basri, Siti Fathiah Masre, Ahmad Rohi Ghazali","doi":"10.15430/JCP.26.015","DOIUrl":"10.15430/JCP.26.015","url":null,"abstract":"Non-melanoma skin cancer remains among the most prevalent malignancies globally. This study investigated the protective potential of a terpenoid-rich extract from Canarium odontophyllum Miq. leaves (TRCO) in a 7,12-dimethylbenz[a]anthracene (DMBA) and ultraviolet B (UVB)-induced two-stage skin carcinogenesis (DMBA/UVB) model using BALB/c mice, focusing primarily on its action during the tumor promotion stage. Mice were topically treated with TRCO at 100 µg (TRCO100) and 200 µg (TRCO200) prior to DMBA/UVB exposure. The protective activities were evaluated based on macroscopic skin changes, histopathology, antioxidant enzyme activities, melanogenesis parameters, and expression levels of key tumor-associated markers (p53, Ki67, and VEGF). TRCO treatment significantly reduced DMBA/UVB-induced erythema, epidermal hyperplasia, and melanogenesis. TRCO modulated antioxidant enzyme activities (total SOD, CAT, GSH-Px and GST) and significantly lowered oxidative stress biomarkers. Expression of p53, Ki67, and VEGF was markedly modulated, with the TRCO100 group showing pronounced variations. These findings suggest that TRCO exerts promising protective potential against preneoplastic skin progression in a two-stage carcinogenesis model, most likely through integrated antioxidant, anti-inflammatory, and antiproliferative tissue mechanisms.","PeriodicalId":15120,"journal":{"name":"Journal of Cancer Prevention","volume":"31 3","pages":"153-161"},"PeriodicalIF":2.5,"publicationDate":"2026-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13423741/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148653621","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Insights into the Relevance of the Interaction between Colorectal Cancer and Gut Microbiota-Derived Metabolites. 结直肠癌与肠道微生物衍生代谢物相互作用相关性的见解。

IF 2.5

Journal of Cancer Prevention Pub Date : 2026-07-30 Epub Date: 2026-03-23 DOI: 10.15430/JCP.25.057

Eun-Ju Kim, Sun-Young Hwang, KyoungOk No, Mee-Hyun Lee

{"title":"Insights into the Relevance of the Interaction between Colorectal Cancer and Gut Microbiota-Derived Metabolites.","authors":"Eun-Ju Kim, Sun-Young Hwang, KyoungOk No, Mee-Hyun Lee","doi":"10.15430/JCP.25.057","DOIUrl":"10.15430/JCP.25.057","url":null,"abstract":"Colorectal cancer (CRC) is strongly associated with gut microbial dysbiosis, characterized by increases in Escherichia coli, Enterococcus faecalis, and Bacteroides spp., and reduction in short chain fatty acid producing taxa such as Akkermansia muciniphila, Faecalibacterium prausnitzii, and Roseburia. These shifts parallel metabolomic disturbances, including decreased butyrate and immune dysregulation. Several microbial and metabolic markers such as Akkermansia, Faecalibacterium, butyrate, tryptophan metabolites, and sarcosine have demonstrated strong diagnostic performance, with area under the receiver operating characteristic curve (AUC) values commonly ranging from 0.80 to 0.93 in CRC prediction models. This review integrates current evidence for microbes and metabolite interactions that drive CRC progression and summarizes biomarker studies employing high AUC microbial and metabolite signatures for early detection and patient stratification. We further highlight phytochemicals, including resveratrol, curcumin, and quercetin which mitigate CRC by modulating cyclooxygenase-2 activity, macrophage polarization, inflammatory cytokine signaling, and metabolic pathways, as well as the restoration of beneficial gut microbial communities. These insights support the advancement of microbiome targeted and metabolite informed approaches for CRC risk assessment, diagnosis, and therapeutic development.","PeriodicalId":15120,"journal":{"name":"Journal of Cancer Prevention","volume":"31 3","pages":"140-152"},"PeriodicalIF":2.5,"publicationDate":"2026-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13423742/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148653479","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Curcumin Attenuates Breast Cancer Cell-induced Inflammasome Activation via the NOD-like receptor protein 3/Caspase-1/Interleukin-1β Axis. 姜黄素通过nod样受体蛋白3/Caspase-1/白细胞介素-1β轴减弱乳腺癌细胞诱导的炎性体激活。

IF 2.5

Journal of Cancer Prevention Pub Date : 2026-07-30 Epub Date: 2026-07-02 DOI: 10.15430/JCP.26.026

Khwandow Kunchana, Wattanased Jarisarapurin, Jeong-Hoon Jang, Suvara Wattanapitayakul, Young-Joon Surh

{"title":"Curcumin Attenuates Breast Cancer Cell-induced Inflammasome Activation via the NOD-like receptor protein 3/Caspase-1/Interleukin-1β Axis.","authors":"Khwandow Kunchana, Wattanased Jarisarapurin, Jeong-Hoon Jang, Suvara Wattanapitayakul, Young-Joon Surh","doi":"10.15430/JCP.26.026","DOIUrl":"10.15430/JCP.26.026","url":null,"abstract":"Breast cancer is one of the most prevalent malignancies among women worldwide; its incidence and mortality are expected to increase annually. Cancer is composed not only malignant cells but also a complex and dynamic network of interacting stromal cells, specifically immune cells, which contribute to tumor development and progression. Increasing evidence highlights the critical role of tumor-associated macrophages (TAMs) and their inflammasome-driven signaling pathways in tumor progression and therapeutic resistance. Curcumin, a natural compound with anti-carcinogenic potential, has a role in the regulation of cancer development and progression. However, its specific effects on inflammasome activation in TAMs within the tumor microenvironment (TME) remain insufficiently characterized. THP-1 monocytes differentiated into macrophages acquire the TAM-like phenotype when treated with conditioned media from breast cancer cells. Our present study aimed to investigate the effects of curcumin on inflammasome activation in macrophages induced by breast cancer-derived conditioned media. Breast cancer-derived conditioned medium stimulation induced manifestation of a pro-inflammatory TAM-like phenotype, characterized by increased interleukin (IL)-1β secretion and upregulation of NOD-like receptor protein 3 (NLRP3), caspase-1, and IL-1β. Curcumin pretreatment significantly reduced IL-1β secretion as well as NLRP3 protein levels. Moreover, it also suppressed IL1B and CASP1 mRNA expression. In conclusion, curcumin attenuates tumor-induced inflammasome activation, highlighting its potential to modulate TME-driven breast cancer progression via the NLRP3/caspase-1/IL-1β axis.","PeriodicalId":15120,"journal":{"name":"Journal of Cancer Prevention","volume":"31 3","pages":"172-181"},"PeriodicalIF":2.5,"publicationDate":"2026-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13423743/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148653928","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Association of Daily Alcohol Consumption and Drinking Patterns with Risk of Primary Malignant Brain Tumor in Korean Adults: A Retrospective Cohort Study. 韩国成年人每日饮酒量和饮酒方式与原发性恶性脑肿瘤风险的关系：一项回顾性队列研究

IF 2.5

Journal of Cancer Prevention Pub Date : 2026-07-30 Epub Date: 2026-06-18 DOI: 10.15430/JCP.26.006

Ji-Woo Woo, Mi Kyung Kim, Jihye Kim, Hye Won Woo, Jun Hwan Cho, Heejun Yoo

{"title":"Association of Daily Alcohol Consumption and Drinking Patterns with Risk of Primary Malignant Brain Tumor in Korean Adults: A Retrospective Cohort Study.","authors":"Ji-Woo Woo, Mi Kyung Kim, Jihye Kim, Hye Won Woo, Jun Hwan Cho, Heejun Yoo","doi":"10.15430/JCP.26.006","DOIUrl":"10.15430/JCP.26.006","url":null,"abstract":"Evidence on whether alcohol consumption and drinking patterns contribute to the risk of primary malignant brain tumors remains limited. We examined associations of daily alcohol consumption, drinking frequency, and heavy episodic drinking with tumor incidence in a nationwide cohort. We analyzed data from the National Health Insurance Service-National Sample Cohort (version 2.2), including 240,948 adults aged ≥ 20 years who completed a general health screening between 2006 and 2008. Alcohol-related behaviors were assessed using standardized questionnaires. Incident primary malignant brain tumors were identified using code C71 and the special registration code V193. Hazard ratios (HRs) and 95% CIs were estimated using Cox proportional hazards models adjusting for sociodemographic and lifestyle factors. Over a mean follow-up of 12 years, 209 incident malignant brain tumors occurred (7.2 per 100,000 person-years). Daily alcohol consumption and heavy episodic drinking were not associated with tumor risk. In contrast, drinking frequency showed a positive association: participants who drank almost daily had a higher risk (vs. non-drinkers) (HR, 2.61; 95% CI, 1.21-5.61; P-trend = 0.0347). Sensitivity analyses restricted to adults aged ≥ 40 years and excluding early cases (3- or 5-year latency) yielded similar results. No effect modification was observed. In this nationwide Korean cohort, near-daily drinking, rather than daily alcohol consumption or amount consumed per occasion, was associated with an elevated risk of primary malignant brain tumors. These findings suggest that drinking frequency may represent an independent dimension of alcohol exposure relevant to brain tumor risk.","PeriodicalId":15120,"journal":{"name":"Journal of Cancer Prevention","volume":"31 3","pages":"162-171"},"PeriodicalIF":2.5,"publicationDate":"2026-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13423748/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148653933","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Molecular Mechanisms of the Anticancer Activity of the Flavonoid Kaempferol: A Comprehensive Review. 山奈酚类黄酮抗癌作用的分子机制综述

IF 2.5

Journal of Cancer Prevention Pub Date : 2026-07-30 Epub Date: 2026-06-11 DOI: 10.15430/JCP.26.014

Mingxiao Cui, Yan Zhao, Yue Wang

{"title":"Molecular Mechanisms of the Anticancer Activity of the Flavonoid Kaempferol: A Comprehensive Review.","authors":"Mingxiao Cui, Yan Zhao, Yue Wang","doi":"10.15430/JCP.26.014","DOIUrl":"10.15430/JCP.26.014","url":null,"abstract":"Kaempferol (KAE), a natural flavonoid, has emerged as a promising multi-target antineoplastic agent characterized by high efficacy and minimal systemic toxicity. Moving beyond fragmented descriptive summaries, this comprehensive review provides a highly integrated conceptual framework of KAE's anticancer mechanisms. Specifically, KAE orchestrates tumor eradication by enforcing cell cycle arrest across multiple phases and triggering a complex, interconnected network of programmed cell death. We highlight how reactive oxygen species and endoplasmic reticulum stress serve as central upstream nodes driving the mechanistic crosstalk among apoptosis, lethal autophagy, gasdermin E-mediated pyroptosis, and ferroptosis. Furthermore, KAE actively remodels the tumor microenvironment by inhibiting angiogenesis and repolarizing tumor-associated macrophages, thereby converting immunosuppressive \"cold\" tumors into immune-active \"hot\" tumors. Notably, this review introduces the emerging prebiotic-like crosstalk between KAE and the gut microbiome, providing a strong mechanistic rationale for its synergistic application with immune checkpoint inhibitors. As a potent chemosensitizer, KAE also overcomes multidrug resistance and mitigates chemotherapy-induced toxicities. Finally, we critically evaluate current translational bottlenecks-including the disparity between supraphysiological in vitro concentrations and clinical pharmacokinetics, the lack of robust in vivo validations, and the long-term biosafety of emerging nano-delivery systems. By addressing these critical limitations, this review offers strategic perspectives to bridge the gap from preliminary bench research to future precision oncological practice.","PeriodicalId":15120,"journal":{"name":"Journal of Cancer Prevention","volume":"31 3","pages":"116-126"},"PeriodicalIF":2.5,"publicationDate":"2026-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13423752/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148653668","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Berry-derived Bioactive Compounds as Chemopreventive Agents in Colorectal Cancer: Molecular Mechanisms and Gut Microbiota Interactions. 浆果衍生的生物活性化合物作为结直肠癌的化学预防剂：分子机制和肠道微生物群的相互作用。

IF 2.5

Journal of Cancer Prevention Pub Date : 2026-07-30 Epub Date: 2026-05-29 DOI: 10.15430/JCP.26.020

Wilairat Leeanansaksiri, Chavaboon Dechsukhum

{"title":"Berry-derived Bioactive Compounds as Chemopreventive Agents in Colorectal Cancer: Molecular Mechanisms and Gut Microbiota Interactions.","authors":"Wilairat Leeanansaksiri, Chavaboon Dechsukhum","doi":"10.15430/JCP.26.020","DOIUrl":"10.15430/JCP.26.020","url":null,"abstract":"Berry-derived bioactive compounds are increasingly recognized as promising chemopreventive agents for colorectal cancer (CRC). CRC develops through a multistep process involving genetic, epigenetic, inflammatory, and microbiota-related alterations. Polyphenol-rich berries are abundant in anthocyanins, ellagitannins, ellagic acid, quercetin, and related phytochemicals. These compounds target multiple hallmarks of colorectal carcinogenesis. Experimental studies have shown that berry-derived compounds exert anti-proliferative effects by inducing cell-cycle arrest at the G0/G1, S, or G2/M phase. These effects are associated with modulation of cyclin-dependent kinases (CDK), and CDK inhibitors such as p21 and p27. In addition, they inhibit key oncogenic signaling pathways, including Wnt/β-catenin, NF-κB, PI3K/Akt, and ERK/MAPK. Berry phytochemicals also promote programmed cell death. Thus, they activate both intrinsic and extrinsic apoptotic pathways, alter the balance of Bcl-2 family proteins, disrupt mitochondrial integrity, and induce caspase activation. Moreover, berry compounds attenuate chronic inflammation by downregulating expression/production of COX-2, inducible nitric oxide synthase, and pro-inflammatory cytokines through suppression of NF-κB- and STAT3-dependent signaling. Further, they also enhance Nrf2-mediated antioxidant responses. Although parent polyphenols have limited bioavailability, they are extensively metabolized by gut microbiota into bioactive compounds such as protocatechuic acid and urolithins. These metabolites often exhibit comparable or greater anticancer activity and reach physiologically relevant concentrations in the colorectum. Berry polyphenols further modulate gut microbiota composition, promoting beneficial microbes and reinforcing anti-carcinogenic signaling. Altogether, these mechanisms highlight berry-derived compounds as strong candidates for CRC chemoprevention, which merits further clinical investigation.","PeriodicalId":15120,"journal":{"name":"Journal of Cancer Prevention","volume":"31 3","pages":"127-139"},"PeriodicalIF":2.5,"publicationDate":"2026-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13423754/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148653993","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Truncating Adenomatous Polyposis Coli Mutations Serve as a Biomarker for Advanced Tumor Stage in Iranian Patients with Familial Colorectal Cancer. 截断性腺瘤性大肠息肉突变可作为伊朗家族性结直肠癌患者肿瘤晚期的生物标志物。

IF 2.5

Journal of Cancer Prevention Pub Date : 2026-04-30 DOI: 10.15430/JCP.25.043

Ali Zarei, Abolfazl Khalafi-Nezhad, Sara Senemar, Ahmad Abdollahi, Mohammad Javad Fattahi

{"title":"Truncating Adenomatous Polyposis Coli Mutations Serve as a Biomarker for Advanced Tumor Stage in Iranian Patients with Familial Colorectal Cancer.","authors":"Ali Zarei, Abolfazl Khalafi-Nezhad, Sara Senemar, Ahmad Abdollahi, Mohammad Javad Fattahi","doi":"10.15430/JCP.25.043","DOIUrl":"10.15430/JCP.25.043","url":null,"abstract":"The Adenomatous Polyposis Coli gene (APC) is a key tumor suppressor in colorectal cancer (CRC). While germline mutations in its Mutation Cluster Region (MCR) are implicated in familial CRC, the prognostic impact of specific mutation types within distinct populations remains poorly characterized. This study sequenced the APC-MCR in 96 Iranian familial CRC patients, 6 disease controls (gastritis/celiac), and 10 healthy controls. Variants were classified per ACMG guidelines. Patients were stratified into four genetic categories: Wild-Type (WT), Variant of Uncertain Significance (VUS) only, Truncating pathogenic/likely pathogenic (P/LP), and Missense P/LP. Associations with clinicopathological features were assessed using Chi-square, Fisher's exact tests, and independent t-tests. OR with 95% CI were calculated. Pathogenic mutations were identified in 39.6% (38/96) of patients and 0% of controls (P < 0.0001). A significant association existed between the mutation type and the tumor stage (P = 0.001). Advanced-stage (III/IV) disease was present in 22.2% of WT, 31.8% of VUS only, 61.3% of Truncating P/LP, and 71.4% of Missense P/LP patients. Truncating P/LP mutations conferred significantly higher odds of advanced-stage disease (OR = 5.54, 95% CI: 1.98-15.51, P = 0.001) versus WT. No significant association was found with age, sex, grade, or tumor location. The type of APC mutation, specifically truncating variants, is a powerful biomarker for advanced tumor stage in Iranian familial CRC, underscoring the critical need for genotype-driven risk stratification.","PeriodicalId":15120,"journal":{"name":"Journal of Cancer Prevention","volume":"31 2","pages":"100-106"},"PeriodicalIF":2.5,"publicationDate":"2026-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13128501/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147815474","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Establishment of a Gastric Cancer Diagnostic Model Based on the Combined Evaluation of Peripheral Blood Immune-inflammatory Nutritional Indicators and Tumor Markers. 基于外周血免疫炎性营养指标与肿瘤标志物联合评价胃癌诊断模型的建立

IF 2.5

Journal of Cancer Prevention Pub Date : 2026-04-30 DOI: 10.15430/JCP.25.049

Ke Chen, Jinglue Han, Xiaoxue Zhang, He Nie, Lijia Ding, Lin Ji, Huazhen Zhang, Jie Yin, Yunan Zhang, Wenying Tian, Jiale Lv, Qiang Zhan, Fangmei An, Zhifa Lv, Shuping Si

{"title":"Establishment of a Gastric Cancer Diagnostic Model Based on the Combined Evaluation of Peripheral Blood Immune-inflammatory Nutritional Indicators and Tumor Markers.","authors":"Ke Chen, Jinglue Han, Xiaoxue Zhang, He Nie, Lijia Ding, Lin Ji, Huazhen Zhang, Jie Yin, Yunan Zhang, Wenying Tian, Jiale Lv, Qiang Zhan, Fangmei An, Zhifa Lv, Shuping Si","doi":"10.15430/JCP.25.049","DOIUrl":"10.15430/JCP.25.049","url":null,"abstract":"This study aimed to develop a non-invasive diagnostic model for gastric cancer (GC) by combining serum immune-inflammatory-nutrition indicators with traditional tumor markers to improve early diagnosis efficiency. Our retrospective analysis included 3,464 participants, comprising 833 GC patients and 2,631 chronic gastritis controls, recruited between January 2018 and July 2025. The dataset was split into training and validation sets at a 7 : 3 ratio, and least absolute shrinkage and selection operator (LASSO) regression was utilized to screen for characteristic variables. Of the candidate variables, seven key features-age, sex, body mass index, carcinoembryonic antigen, carbohydrate antigen 199, systemic immune-inflammation index/albumin (SII/ALB), and prognostic nutritional index (PNI)-were identified and integrated into a multivariate logistic regression model. The analysis indicated that advanced age (OR, 1.23; 95% CI, 1.20-1.26) and elevated SII/ALB ratios (OR, 2.63; 95% CI, 1.93-3.58) were significant risk factors, whereas higher PNI values (OR, 0.12; 95% CI, 0.09-0.17) were associated with a reduced risk. The model demonstrated excellent diagnostic performance, achieving an area under the curve of 0.93 (95% CI, 0.91-0.94) in the training set and 0.92 (95% CI, 0.90-0.94) in the validation set. Subgroup analysis further revealed that the seven key markers were significantly associated with Lauren classification, histological grade, and tumor-node-metastasis stage, progressively worsening with disease advancement. Our study underscores the high accuracy and clinical utility of this multimodal model, providing a reliable, non-invasive tool for the early screening and personalized pretreatment assessment of gastric cancer.","PeriodicalId":15120,"journal":{"name":"Journal of Cancer Prevention","volume":"31 2","pages":"70-81"},"PeriodicalIF":2.5,"publicationDate":"2026-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13128506/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147815342","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Oral Administration of Withaferin A Increases Infiltration of CD4⁺ Helper T Cells in a Mouse Model of Mammary Tumor. 口服Withaferin A可增加小鼠乳腺肿瘤模型中CD4+辅助性T细胞的浸润。

IF 2.5

Journal of Cancer Prevention Pub Date : 2026-04-30 DOI: 10.15430/JCP.26.011

Eun-Ryeong Hahm, Krishna B Singh, Shivendra V Singh

{"title":"Oral Administration of Withaferin A Increases Infiltration of CD4+ Helper T Cells in a Mouse Model of Mammary Tumor.","authors":"Eun-Ryeong Hahm, Krishna B Singh, Shivendra V Singh","doi":"10.15430/JCP.26.011","DOIUrl":"10.15430/JCP.26.011","url":null,"abstract":"Withaferin A (WA) is a small molecule present in Ashwagandha plant that prevents breast cancer progression in mice and rats. The mechanisms underlying breast cancer prevention by WA are not fully understood. Herein, we report effects of WA treatment on an immune landscape in C3(1)-TAg transgenic mice, which develop basal-like breast cancer. Oral administration of 12 mg/kg body weight of WA decreased the wet tumor weight by about 43%. Weight loss or any other adverse effects (e.g., impaired movement, hunched back, ruffled fur, etc.) were not observed. Tumors and splenocytes from WA-treated mice exhibited the increased proportion of CD4+ helper T cells when compared to control mice. The proportion of CD8α+ T cells and natural killer cells was not affected by WA treatment in either mammary tumor or splenocytes. Similarly, the proportions of lymphoid dendritic cells, myeloid dendritic cells, M2 macrophages, regulatory T cells, and myeloid-derived suppressor cells were comparable in mammary tumors and splenocytes of both control and WA-treated mice. Unlike the C3(1)-TAg mouse model, WA administration failed to increase the proportion of CD4+ T cells in mammary tumors of rats. The present study indicates that even though WA treatment increases the proportion of helper T cells in mammary tumors and spleen, attenuation of immune evasion may have a minimal role in its breast cancer prevention at least in rodent models of basal-like [C3(1)-TAg model] and luminal-type (rat model) breast cancer.","PeriodicalId":15120,"journal":{"name":"Journal of Cancer Prevention","volume":"31 2","pages":"91-99"},"PeriodicalIF":2.5,"publicationDate":"2026-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13128505/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147815469","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0