Journal of Cancer Prevention最新文献_第10页

F-box Protein βTrCP1 Is a Substrate of Extracellular Signal-regulated Kinase 2. F-box蛋白βTrCP1是细胞外信号调节激酶2的底物。

IF 2.5

Journal of Cancer Prevention Pub Date : 2021-09-30 DOI: 10.15430/JCP.2021.26.3.174

Cheol-Jung Lee, Ga-Eun Lee, Hyun-Jung An, Eun Suh Cho, Weidong Chen, Joo Young Lee, Han Chang Kang, Hye Suk Lee, Yong-Yeon Cho

{"title":"F-box Protein βTrCP1 Is a Substrate of Extracellular Signal-regulated Kinase 2.","authors":"Cheol-Jung Lee, Ga-Eun Lee, Hyun-Jung An, Eun Suh Cho, Weidong Chen, Joo Young Lee, Han Chang Kang, Hye Suk Lee, Yong-Yeon Cho","doi":"10.15430/JCP.2021.26.3.174","DOIUrl":"https://doi.org/10.15430/JCP.2021.26.3.174","url":null,"abstract":"F-box proteins, consisting of 69 members which are organized into the three subclasses FBXW, FBXL, and FBXO, are the substrate specific recognition subunits of the SKP1-Cullin 1-F-box protein E3 ligase complex. Although βTrCP 1 and 2, members of the FBXW subfamily, are known to regulate some protein stability, molecular mechanisms by which these proteins can recognize proper substrates are unknown. In this study, it was found that βTrCP1 showed strong interaction with members of mitogen-activated protein kinases. Although extracellular signal-regulated kinase (ERK) 3, p38β, and p38δ showed weak interactions, ERK2 specifically interacted with βTrCP1 as assessed by immunoprecipitation. In interaction domain determination experiments, we found that ERK2 interacted with two independent ERK docking sites located in the F-box domain and linker domain, but not the WD40 domain, of βTrCP1. Notably, mutations of βTrCP1 at the ERK docking sites abolished the interaction with ERK2. βTrCP1 underwent phosphorylation by EGF stimulation, while the presence of the mitogen-activated protein kinase kinases inhibitor U0126, genetic silencing by sh-ERK2, and mutation of the ERK docking site of βTrCP1 inhibited phosphorylation. This inhibition of βTrCP1 phosphorylation resulted in a shortened half-life and low protein levels. These results suggest that ERK2-mediated βTrCP1 phosphorylation may induce the destabilization of βTrCP1.","PeriodicalId":15120,"journal":{"name":"Journal of Cancer Prevention","volume":"26 3","pages":"174-182"},"PeriodicalIF":2.5,"publicationDate":"2021-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/d6/38/jcp-26-3-174.PMC8511579.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39561312","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Docosahexaenoic Acid Inhibits Cytokine Expression by Reducing Reactive Oxygen Species in Pancreatic Stellate Cells. 二十二碳六烯酸通过减少胰腺星状细胞中的活性氧抑制细胞因子的表达。

IF 2.5

Journal of Cancer Prevention Pub Date : 2021-09-30 DOI: 10.15430/JCP.2021.26.3.195

Sun Ah Chung, Joo Weon Lim, Hyeyong Kim

{"title":"Docosahexaenoic Acid Inhibits Cytokine Expression by Reducing Reactive Oxygen Species in Pancreatic Stellate Cells.","authors":"Sun Ah Chung, Joo Weon Lim, Hyeyong Kim","doi":"10.15430/JCP.2021.26.3.195","DOIUrl":"https://doi.org/10.15430/JCP.2021.26.3.195","url":null,"abstract":"Pancreatic stellate cells (PSCs) are activated by inflammatory stimuli, such as TNF-α or viral infection. Activated PSCs play a crucial role in the development of chronic pancreatitis. Polyinosinic-polycytidylic acid (poly (I:C)) is structurally similar to double-stranded RNA and mimics viral infection. Docosahexaenoic acid (DHA) exhibits anti-inflammatory activity. It inhibited fibrotic mediators and reduced NF-κB activity in the pancreas of mice with chronic pancreatitis. The present study aimed to investigate whether DHA could suppress cytokine expression in PSCs isolated from rats. Cells were pre-treated with DHA or the antioxidant N-acetylcysteine (NAC) and stimulated with TNF-α or poly (I:C). Treatment with TNF-α or poly (I:C) increased the expression of monocyte chemoattractant protein 1 (MCP-1) and chemokine C-X3-C motif ligand 1 (CX3CL1), which are known chemoattractants, and enhanced intracellular and mitochondrial reactive oxygen species (ROS) production and NF-κB activity, but reduced mitochondrial membrane potential (MMP). Increased intracellular and mitochondrial ROS accumulation, cytokine expression, MMP disruption, and NF-κB activation were all prevented by DHA in TNF-α- or poly (I:C)-treated PSCs. NAC suppressed TNF-α- or poly (I:C)-induced expression of MCP-1 and CX3CL1. In conclusion, DHA inhibits poly (I:C)- or TNF-α-induced cytokine expression and NF-κB activation by reducing intracellular and mitochondrial ROS in PSCs. Consumption of DHA-rich foods may be beneficial in preventing chronic pancreatitis by inhibiting cytokine expression in PSCs.","PeriodicalId":15120,"journal":{"name":"Journal of Cancer Prevention","volume":"26 3","pages":"195-206"},"PeriodicalIF":2.5,"publicationDate":"2021-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/61/f9/jcp-26-3-195.PMC8511577.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39561314","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Trefoil Factor 1 Suppresses Epithelial-mesenchymal Transition through Inhibition of TGF-beta Signaling in Gastric Cancer Cells. 三叶因子1通过抑制胃癌细胞tgf - β信号传导抑制上皮-间质转化。

IF 2.5

Journal of Cancer Prevention Pub Date : 2021-06-30 DOI: 10.15430/JCP.2021.26.2.137

Da-Young Lee, Moon-Young Song, Eun-Hee Kim

{"title":"Trefoil Factor 1 Suppresses Epithelial-mesenchymal Transition through Inhibition of TGF-beta Signaling in Gastric Cancer Cells.","authors":"Da-Young Lee, Moon-Young Song, Eun-Hee Kim","doi":"10.15430/JCP.2021.26.2.137","DOIUrl":"https://doi.org/10.15430/JCP.2021.26.2.137","url":null,"abstract":"Gastric cancer is a malignancy with high incidence and mortality worldwide. In gastric cancer, epithelial-mesenchymal transition (EMT) and metastasis further increase the mortality rate. Trefoil factor 1 (TFF1) has been reported as a protective factor in the gastric mucosa. In this study, TFF1 inhibited the migration and invasive capability of gastric cancer cells. Elevated TFF1 levels induced the expression of E-cadherin, the epithelial marker, and reduced the expression of N-cadherin, vimentin, Snail, Twist, Zinc finger E-box binding homeobox (ZEB) 1 and ZEB2, well-known repressors of E-cadherin expression. In addition, the expression of matrix metalloproteinase (MMP)-2, MMP-7 and MMP-9, which are major markers of cancer metastasis, was suppressed by TFF1. Upregulation of TFF1 inhibited TGF-β, a major signaling for EMT induction, and the phosphorylation of Smad2/3 activated by TGF-β in AGS cells. In conclusion, TFF1 inhibits EMT through suppression of TGF-β signaling in AGS cells, which might be used in therapeutic strategies for reducing metastatic potential and invasiveness of these cells.","PeriodicalId":15120,"journal":{"name":"Journal of Cancer Prevention","volume":"26 2","pages":"137-144"},"PeriodicalIF":2.5,"publicationDate":"2021-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/41/77/jcp-26-2-137.PMC8249209.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39181436","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

The Role of Sex-specific Long Non-coding RNAs in Cancer Prevention and Therapy. 性别特异性长链非编码rna在癌症防治中的作用。

IF 2.5

Journal of Cancer Prevention Pub Date : 2021-06-30 DOI: 10.15430/JCP.2021.26.2.98

Hye Kyung Song, Sun Young Kim

{"title":"The Role of Sex-specific Long Non-coding RNAs in Cancer Prevention and Therapy.","authors":"Hye Kyung Song, Sun Young Kim","doi":"10.15430/JCP.2021.26.2.98","DOIUrl":"https://doi.org/10.15430/JCP.2021.26.2.98","url":null,"abstract":"The functions of a large number of non-coding genes in human DNA have yet to be accurately identified. Long non-coding RNA (lncRNA) measuring 10 kb or less in length regulates transcription or post-transcriptional events. The lncRNAs have attracted increased attention of researchers in recent years. In this review, we summarize the recently published lncRNAs which are known to influence cancer development and progression. We also discuss recent studies investigating tumor-specific lncRNA expression. These lncRNAs provide very useful information that allows prediction of the degree of malignancy and a survival rate in cancer patients as clinically relevant biomarkers. Because symptoms and progression of cancer differ from onset to death between males and females, it is important to consider the gender of the patient when diagnosing cancer and predicting the progression. Considering the importance of gender difference, we also examine the influence of sex hormones involved in the expression and regulation of lncRNAs as biomarkers. Many of the lncRNAs examined in this review have been studied in cancers occurring in the female or male reproductive organs, but the association between lncRNAs and sex hormones has also been reported in common organs such as the lung, renal and colon. Although lncRNAs have not yet been widely used as definitive cancer indicators, recent studies have demonstrated the potential role of lncRNAs as biomarkers and therapeutic targets reflecting sex-specificity in a number of different cancers.","PeriodicalId":15120,"journal":{"name":"Journal of Cancer Prevention","volume":"26 2","pages":"98-109"},"PeriodicalIF":2.5,"publicationDate":"2021-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/98/d9/jcp-26-2-98.PMC8249206.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39181516","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

Nanoparticles: Weighing the Pros and Cons from an Eco-genotoxicological Perspective. 纳米粒子：从生态遗传毒理学角度权衡利弊。

IF 2.5

Journal of Cancer Prevention Pub Date : 2021-06-30 DOI: 10.15430/JCP.2021.26.2.83

Preeyaporn Koedrith, Md Mujibur Rahman, Yu Jin Jang, Dong Yeop Shin, Young Rok Seo

{"title":"Nanoparticles: Weighing the Pros and Cons from an Eco-genotoxicological Perspective.","authors":"Preeyaporn Koedrith, Md Mujibur Rahman, Yu Jin Jang, Dong Yeop Shin, Young Rok Seo","doi":"10.15430/JCP.2021.26.2.83","DOIUrl":"10.15430/JCP.2021.26.2.83","url":null,"abstract":"The exponential growth of nanotechnology and the industrial production have raised concerns over its impact on human and environmental health and safety (EHS). Although there has been substantial progress in the assessment of pristine nanoparticle toxicities, their EHS impacts require greater clarification. In this review, we discuss studies that have assessed nanoparticle eco-genotoxicity in different test systems and their fate in the environment as well as the considerable confounding factors that may complicate the results. We highlight key mechanisms of nanoparticle-mediated genotoxicity. Then we discuss the reliability of endpoint assays, such as the comet assay, the most favored assessment technique because of its versatility to measure low levels of DNA strand breakage, and the micronucleus assay, which is complementary to the former because of its greater ability to detect chromosomal DNA fragmentation. We also address the current recommendations on experimental design, including environmentally relevant concentrations and suitable exposure duration to avoid false-positive or -negative results. The genotoxicity of nanoparticles depends on their physicochemical features and the presence of co-pollutants. Thus, the effect of environmental processes (e.g., aggregation and agglomeration, adsorption, and transformation of nanoparticles) would account for when determining the actual genotoxicity relevant to environmental systems, and assay procedures must be standardized. Indeed, the engineered nanoparticles offer potential applications in different fields including biomedicine, environment, agriculture, and industry. Toxicological pathways and the potential risk factors related to genotoxic responses in biological organisms and environments need to be clarified before appropriate and sustainable applications of nanoparticles can be established.","PeriodicalId":15120,"journal":{"name":"Journal of Cancer Prevention","volume":"26 2","pages":"83-97"},"PeriodicalIF":2.5,"publicationDate":"2021-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/85/53/jcp-26-2-83.PMC8249203.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39181515","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Mechanistic Targets of Diallyl Trisulfide in Human Breast Cancer Cells Identified by RNA-seq Analysis. 通过 RNA-seq 分析确定二烯丙基三硫醚在人类乳腺癌细胞中的机制靶点

IF 2.5

Journal of Cancer Prevention Pub Date : 2021-06-30 DOI: 10.15430/JCP.2021.26.2.128

Eun-Ryeong Hahm, Su-Hyeong Kim, Sivapar V Mathan, Rana P Singh, Shivendra V Singh

{"title":"Mechanistic Targets of Diallyl Trisulfide in Human Breast Cancer Cells Identified by RNA-seq Analysis.","authors":"Eun-Ryeong Hahm, Su-Hyeong Kim, Sivapar V Mathan, Rana P Singh, Shivendra V Singh","doi":"10.15430/JCP.2021.26.2.128","DOIUrl":"10.15430/JCP.2021.26.2.128","url":null,"abstract":"Diallyl trisulfide (DATS), a metabolic by-product of processed garlic, is highly effective in inhibiting growth of human breast cancer cells in vitro and in vivo, but the underlying mechanisms are still not fully understood. In this study, we performed RNA-seq analyses using luminal-type (MCF-7) and basal-like (MDA-MB-231) human breast cancer cells to identify mechanistic targets of DATS. The Reactome Pathway Analysis revealed upregulation of genes associated with SLIT/ROBO tumor suppressor signaling following DATS treatment in both MCF-7 and MDA-MB-231 cells. However, the expression of SLIT2 and ROBO1 proteins or their downstream target C-X-C motif chemokine receptor 4 was not affected by DATS treatment in both cell lines. The Reactome as well as the Gene Ontology Pathways Analyses of the RNA-seq data from DATS-treated cells indicated downregulation of genes associated with G2/M phase cell cycle arrest in comparison with vehicle-treated control cells. Consistent with the RNA-seq data, DATS treatment caused a significant increase in the fraction of the G2/M population in both cell lines when compared to corresponding control cells. In addition, Ser10 phosphorylation of histone H3, a mitotic marker, was also increased significantly following DATS treatment in MCF-7 and MDA-MB-231 cells. These results indicate that while SLIT/ROBO signaling is not affected by DATS treatment, cell cycle arrest likely contributes to the antitumor effect of this phytochemical.","PeriodicalId":15120,"journal":{"name":"Journal of Cancer Prevention","volume":"26 2","pages":"128-136"},"PeriodicalIF":2.5,"publicationDate":"2021-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/f0/3f/jcp-26-2-128.PMC8249207.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39181435","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cryptotanshinone Prevents the Binding of S6K1 to mTOR/Raptor Leading to the Suppression of mTORC1-S6K1 Signaling Activity and Neoplastic Cell Transformation. 隐丹参酮阻止S6K1与mTOR/Raptor结合，抑制mTORC1-S6K1信号活性和肿瘤细胞转化

IF 2.5

Journal of Cancer Prevention Pub Date : 2021-06-30 DOI: 10.15430/JCP.2021.26.2.145

Nam Ho Jeoung, Ji Yun Jeong, Bong Seok Kang

{"title":"Cryptotanshinone Prevents the Binding of S6K1 to mTOR/Raptor Leading to the Suppression of mTORC1-S6K1 Signaling Activity and Neoplastic Cell Transformation.","authors":"Nam Ho Jeoung, Ji Yun Jeong, Bong Seok Kang","doi":"10.15430/JCP.2021.26.2.145","DOIUrl":"https://doi.org/10.15430/JCP.2021.26.2.145","url":null,"abstract":"Cryptotanshinone is known for its inhibitory activity against tumorigenesis in various human cancer cells. However, exact mechanisms underlying the anticancer effects of cryptotanshinone are not fully elucidated. Here, we propose a plausible molecular mechanism, wherein cryptotanshinone represses rapamycin-sensitive mTORC1/S6K1 mediated cancer cell growth and cell transformation. We investigated the various effects of cryptotanshinone on the mTORC1/S6K1 axis, which is associated with the regulation of cell growth in response to nutritional and growth factor signals. We found that cryptotanshinone specifically inhibited the mTORC1-mediated phosphorylation of S6K1, which consequently suppressed the clonogenicity of SK-Hep1 cells and the neoplastic transformation of JB6 Cl41 cells induced by insulin-like growth factor-1. Finally, we observed that cryptotanshinone prevented S6K1 from binding to the Raptor/mTOR complex, rather than regulating mTOR and its upstream pathway. Overall, our findings provide a novel mechanism underlying anti-cancer effects cryptotanshinone targeting mTORC1 signaling, contributing to the development of anticancer agents involving metabolic cancer treatment.","PeriodicalId":15120,"journal":{"name":"Journal of Cancer Prevention","volume":"26 2","pages":"145-152"},"PeriodicalIF":2.5,"publicationDate":"2021-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/a9/cc/jcp-26-2-145.PMC8249204.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39181437","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Income and Education Inequalities in Brain and Central Nervous System Cancer Incidence in Canada: Trends over Two Decades. 加拿大脑和中枢神经系统癌症发病率的收入和教育不平等:二十年来的趋势。

IF 2.5

Journal of Cancer Prevention Pub Date : 2021-06-30 DOI: 10.15430/JCP.2021.26.2.110

Alysha Roberts, Min Hu, Mohammad Hajizadeh

{"title":"Income and Education Inequalities in Brain and Central Nervous System Cancer Incidence in Canada: Trends over Two Decades.","authors":"Alysha Roberts, Min Hu, Mohammad Hajizadeh","doi":"10.15430/JCP.2021.26.2.110","DOIUrl":"https://doi.org/10.15430/JCP.2021.26.2.110","url":null,"abstract":"The socioeconomic gradient of brain and central nervous system (CNS) cancer incidence in Canada is poorly understood. This study aimed to measure socioeconomic inequalities in brain and CNS cancer incidence in Canada from 1992 to 2010. Using a unique census division level dataset (n = 280) pooled from the Canadian Cancer Registry (CCR), the Canadian Census of Population and the National Household Survey, we measured brain and CNS cancer incidence in Canada. The age-adjusted concentration index (C) was used to measure income- and education-related inequalities in brain and CNS cancers in Canada, and for men and women, separately. Time trend analyses were conducted to examine the changes in socioeconomic inequalities in brain and CNS cancers in Canada over time. The results indicated that the crude brain and CNS cancer incidence increased from 7.29 to 8.17 per 100,000 (annual percentage change: 0.70) over the study period. The age-adjusted C results suggested that the brain and CNS cancer incidence was not generally significantly different for census division of different income and educational levels. There was insufficient evidence to support changes in income and education-related inequalities over time. Since the incidence of brain and CNS cancers in Canada showed no significant association with socioeconomic status, future cancer control programs should focus on other risk factors for this cancer subset.","PeriodicalId":15120,"journal":{"name":"Journal of Cancer Prevention","volume":"26 2","pages":"110-117"},"PeriodicalIF":2.5,"publicationDate":"2021-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/5d/a7/jcp-26-2-110.PMC8249205.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39181517","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Protective Effects of Silibinin on Helicobacter pylori-induced Gastritis: NF-κB and STAT3 as Potential Targets. 水飞蓟宾对幽门螺杆菌性胃炎的保护作用:NF-κB和STAT3为潜在靶点。

IF 2.5

Journal of Cancer Prevention Pub Date : 2021-06-30 DOI: 10.15430/JCP.2021.26.2.118

Kyunghwa Cho, Hee Geum Lee, Juan-Yu Piao, Su-Jung Kim, Hye-Kyung Na, Young-Joon Surh

{"title":"Protective Effects of Silibinin on Helicobacter pylori-induced Gastritis: NF-κB and STAT3 as Potential Targets.","authors":"Kyunghwa Cho, Hee Geum Lee, Juan-Yu Piao, Su-Jung Kim, Hye-Kyung Na, Young-Joon Surh","doi":"10.15430/JCP.2021.26.2.118","DOIUrl":"https://doi.org/10.15430/JCP.2021.26.2.118","url":null,"abstract":"More than half of the world's populations are considered to be infected by Helicobacter pylori. It causes a chronic inflammation of the stomach, which is implicated in the pathogenesis of gastric ulcer and cancer. Silibinin, a polyphenolic flavonoid derived from milk thistle, has been known for its hepatoprotective effects, and recent studies have revealed its chemopreventive potential. In the present study, we examined the anti-inflammatory effects of silibinin in human gastric cancer MKN-1 cells and in the stomach of C57BL/6 mice infected by H. pylori. Pretreatment with silibinin attenuated the up-regulation of COX-2 and inducible nitric oxide synthase (iNOS) in H. pylori-infected MKN-1 cells and mouse stomach. In addition, the elevated translocation and DNA binding of NF-κB and STAT3 induced by H. pylori infection were inhibited by silibinin treatment. Moreover, H. pylori infection in combination with high salt diet resulted in dysplasia and hyperplasia in mouse stomach, and these pathological manifestations were substantially mitigated by silibinin administration. Taken together, these findings suggest that silibinin exerts anti-inflammatory effects against H. pylori infection through suppression of NF-κB and STAT3 and subsequently, expression of COX-2 and iNOS.","PeriodicalId":15120,"journal":{"name":"Journal of Cancer Prevention","volume":"26 2","pages":"118-127"},"PeriodicalIF":2.5,"publicationDate":"2021-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/33/01/jcp-26-2-118.PMC8249208.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39181434","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 8

Understanding the Mechanistic Link between Bisphenol A and Cancer Stem Cells: A Cancer Prevention Perspective. 了解双酚 A 与癌症干细胞之间的机制联系：癌症预防视角》。

IF 2.5

Journal of Cancer Prevention Pub Date : 2021-03-30 DOI: 10.15430/JCP.2021.26.1.18

Cassandra Winz, Nanjoo Suh

引用次数: 5