Journal of Cancer Prevention最新文献_第6页

Economic Burden of Cancer for the First Five Years after Cancer Diagnosis in Patients with Human Immunodeficiency Virus in Korea. 韩国人类免疫缺陷病毒(hiv)患者诊断癌症后头5年的癌症经济负担

IF 2.5

Journal of Cancer Prevention Pub Date : 2023-06-30 DOI: 10.15430/JCP.2023.28.2.53

Yoonyoung Jang, Taehwa Kim, Brian H S Kim, Jung Ho Kim, Hye Seong, Youn Jeong Kim, Boyoung Park

{"title":"Economic Burden of Cancer for the First Five Years after Cancer Diagnosis in Patients with Human Immunodeficiency Virus in Korea.","authors":"Yoonyoung Jang, Taehwa Kim, Brian H S Kim, Jung Ho Kim, Hye Seong, Youn Jeong Kim, Boyoung Park","doi":"10.15430/JCP.2023.28.2.53","DOIUrl":"https://doi.org/10.15430/JCP.2023.28.2.53","url":null,"abstract":"This study aimed to estimate the medical cost of cancer in the first five years of diagnosis and in the final six months before death in people who developed cancer after human immunodeficiency virus (HIV) infection in Korea. The study utilized the Korea National Health Insurance Service-National Health Information Database (NHIS-NHID). Among 16,671 patients diagnosed with HIV infection from 2004 to 2020 in Korea, we identified 757 patients newly diagnosed with cancer after HIV diagnosis. The medical costs for 60 months after diagnosis and the last six months before death were calculated from 2006 to 2020. The mean annual medical cost due to cancer in HIV-infected people with cancer was higher for acquired immunodeficiency syndrome (AIDS)-defining cancers (48,242 USD) than for non-AIDS-defining cancers (24,338 USD), particularly non-Hodgkin's lymphoma (53,007 USD), for the first year of cancer diagnosis. Approximately 25% of the cost for the first year was disbursed during the first month of cancer diagnosis. From the second year, the mean annual medical cost due to cancer was significantly reduced. The total medical cost was higher for non-AIDS-defining cancers, reflecting their higher incidence rates despite lower mean medical costs. The mean monthly total medical cost per HIV-infected person who died after cancer diagnosis increased closer to the time of death. The estimated burden of medical costs in patients with HIV in the present study may be an important index for defining healthcare policies in HIV patients in whom the cancer-related burden is expected to increase.","PeriodicalId":15120,"journal":{"name":"Journal of Cancer Prevention","volume":"28 2","pages":"53-63"},"PeriodicalIF":2.5,"publicationDate":"2023-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10331032/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9814474","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Operational Definition of Liver Cancer in Studies Using Data from the National Health Insurance Service: A Systematic Review. 使用国民健康保险服务数据的研究中肝癌的操作定义:系统回顾。

IF 2.5

Journal of Cancer Prevention Pub Date : 2023-06-30 DOI: 10.15430/JCP.2023.28.2.47

Yu Rim Kim, Ji Yoon Baek, Seung Hee Seo, Hyeree Park, Sooyoung Cho, Aesun Shin, Sup, Sup

{"title":"Operational Definition of Liver Cancer in Studies Using Data from the National Health Insurance Service: A Systematic Review.","authors":"Yu Rim Kim, Ji Yoon Baek, Seung Hee Seo, Hyeree Park, Sooyoung Cho, Aesun Shin, Sup, Sup","doi":"10.15430/JCP.2023.28.2.47","DOIUrl":"https://doi.org/10.15430/JCP.2023.28.2.47","url":null,"abstract":"Data from the Korean National Health Insurance Service (NHIS) have been widely used to provide real-world evidence. Due to the nature of claims data, researchers use operational definitions to define patients with specific diseases. This study aimed to conduct a systematic review of the operational definitions of liver cancer used in studies based on the NHIS database and to suggest the most appropriate operational definition. Literature search was completed on January 6, 2021, using PubMed and KoreaMed. We applied the most frequently used operational definitions of liver cancer to the NHIS-National Sample Cohort and calculated age-standardized incidence rates (ASRs) of liver cancer by year. The ASRs using each operational definition were compared with the ASR from the Korea Central Cancer (KCCR) data. Among 236 articles, 90 were selected for review, covering histologically various kinds of liver cancer and varied by study subjects. Most studies (n = 79) did not mention whether the codes for the operational definition were from only the main diagnosis or from both the main and sub-diagnosis. The most frequently used operational definition was C22 (n = 39); however, the most similar operational definition was the ASR using \"C22.0 or C22.9\" for men and \"C22.0\" for women as the main diagnosis to the ASR from the KCCR. Based on the comparison with KCCR data, we suggest using \"C22.0 or C22.9\" for men and \"C22.0\" for women as the main diagnosis for the operational definition of liver cancer when using the NHIS data.","PeriodicalId":15120,"journal":{"name":"Journal of Cancer Prevention","volume":"28 2","pages":"47-52"},"PeriodicalIF":2.5,"publicationDate":"2023-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10331033/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10191200","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Erratum: Cedrol, a Sesquiterpene Isolated from Juniperus chinensis, Inhibits Human Colorectal Tumor Growth associated through Downregulation of Minichromosome Maintenance Proteins. 从中国杜松中分离的倍半萜雪松醇通过下调微染色体维持蛋白抑制人结直肠肿瘤生长。

IF 2.5

Journal of Cancer Prevention Pub Date : 2023-06-30 DOI: 10.15430/JCP.2023.28.2.75

Soojung Jin, Jung-Ha Park, Hee Jung Yun, You Na Oh, Seunghye Oh, Yung Hyun Choi, Byung Woo Kim, Hyun Ju Kwon

引用次数: 0

Immunohistochemistry versus PCR Technology for Molecular Subtyping of Breast Cancer: Multicentered Expereinces from Addis Ababa, Ethiopia. 免疫组织化学与PCR技术用于乳腺癌分子分型:来自埃塞俄比亚亚的斯亚贝巴的多中心经验。

IF 2.5

Journal of Cancer Prevention Pub Date : 2023-06-30 DOI: 10.15430/JCP.2023.28.2.64

Dessiet Oma, Maria Teklemariam, Daniel Seifu, Zelalem Desalegn, Endale Anberbir, Tamrat Abebe, Solomon Mequannent, Solomon Tebeje, Wajana Lako Labisso

{"title":"Immunohistochemistry versus PCR Technology for Molecular Subtyping of Breast Cancer: Multicentered Expereinces from Addis Ababa, Ethiopia.","authors":"Dessiet Oma, Maria Teklemariam, Daniel Seifu, Zelalem Desalegn, Endale Anberbir, Tamrat Abebe, Solomon Mequannent, Solomon Tebeje, Wajana Lako Labisso","doi":"10.15430/JCP.2023.28.2.64","DOIUrl":"https://doi.org/10.15430/JCP.2023.28.2.64","url":null,"abstract":"The application of immunohistochemistry (IHC) for molecular characterization of breast cancer (BC) is of paramount importance; however, it is not universally standardized, subject to observer variability and quantifying is a challenge. An alternative molecular technology, such as endpoint reverse transcription (RT)-PCR gene expression analysis, may improve observer variability and diagnostic accuracy. This study was intended to compare IHC with the RT-PCR based technique and assess the potential of RT-PCR for molecular subtyping of BC. In this comparative cross-sectional study, 54 BC tissues were collected from three public hospitals in Addis Ababa and shipped to Gynaecology department at Martin-Luther University (Germany) for laboratory analysis. Only 41 samples were qualified for IHC and RT-PCR investigation of estrogen receptor (ER), progesterone receptor (PR), human epidermal growth factor receptor 2 (HER2), and Ki-67 protein expression analysis. Kappa statistics was used to assess the concordance between the two techniques. The overall percent agreement between RT-PCR and IHC was 68.3% for ER (positive percent agreement [PPA] 71.1%; negative percent agreement [NPA] 33.3%), 39.0% for PR (PPA 14.3%; NPA 92.3%), and 82.9% for HER2 (PPA 62.5%; NPA 87.9%). Cohen's κ-values of 0.018 (< 0.20), 0.045 (< 0.200), and 0.481 (0.41-0.60) were generated for ER, PR, and HER2, respectively. Concordance for molecular subtypes was only 56.1% (23/41) and 0.20 kappa value. IHC and endpoint RT-PCR techniques have shown to be discordant for 43% samples. Molecular subtyping using endpoint RT-PCR was fairly concordant with IHC. Thus, endpoint RT-PCR may give an objective result, and can be applied for BC subtyping.","PeriodicalId":15120,"journal":{"name":"Journal of Cancer Prevention","volume":"28 2","pages":"64-74"},"PeriodicalIF":2.5,"publicationDate":"2023-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10331035/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9869887","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Baicalein Inhibits α-Melanocyte-stimulating Hormone-stimulated Melanogenesis via p38 Mitogen-activated Protein Kinase Pathway in B16F10 Mouse Melanoma Cells. 黄芩素通过p38丝裂原激活蛋白激酶途径抑制B16F10小鼠黑色素瘤细胞中α-刺激黑色素细胞激素刺激的黑色素生成

IF 2.5

Journal of Cancer Prevention Pub Date : 2023-06-30 DOI: 10.15430/JCP.2023.28.2.40

Min Chang Oh, Pincha Devage Sameera Madushan Fernando, Mei Jing Piao, Kyoung Ah Kang, Herath Mudiyanselage Udari Lakmini Herath, Jin Won Hyun

引用次数: 0

Facile Titrimetric Assay of Lysophosphatidic Acid in Human Serum and Plasma for Ovarian Cancer Detection. 人血清和血浆溶血磷脂酸快速滴定法检测卵巢癌。

IF 2.5

Journal of Cancer Prevention Pub Date : 2023-06-30 DOI: 10.15430/JCP.2023.28.2.31

Nazia Tarannum, Deepak Kumar, Ranu Agrawal

{"title":"Facile Titrimetric Assay of Lysophosphatidic Acid in Human Serum and Plasma for Ovarian Cancer Detection.","authors":"Nazia Tarannum, Deepak Kumar, Ranu Agrawal","doi":"10.15430/JCP.2023.28.2.31","DOIUrl":"https://doi.org/10.15430/JCP.2023.28.2.31","url":null,"abstract":"Herein, an instrument free facile acid-base titrimetric methodology is reported for lysophosphatidic acid (LPA) measurement in serum and plasma samples for ovarian cancer detection. The concept is based on the titrimetric method in which alkaline solution was titrated with free fatty acid. Free fatty acid is generated due to action of the lysophospholipase to LPA. A phospholipid derivative known as LPA can function as a signaling molecule. A glycerol backbone serves as the foundation for phosphatidic acid, which also has bonds to an unsaturated fatty acid at carbon-1, a hydroxyl group at carbon-2, and a phosphate molecule at carbon-3. Free fatty acid and glycerol-3-phosphate are formed when LPA reacts with lysophospholipase. The formation of free fatty acid depends on the concentration of LPA. The standard graph of known concentrations of LPA, LPA spiked serum and LPA spiked plasma was plotted. The concentration of LPA in unknown serum and plasma were calculated from the standard graph. The limit of detection of LPA in spiked serum and plasma samples via titrimetric assay was calculated as 0.156 μmol/L. A patient's chance of survival may be outweighed by an early diagnosis of ovarian cancer.","PeriodicalId":15120,"journal":{"name":"Journal of Cancer Prevention","volume":"28 2","pages":"31-39"},"PeriodicalIF":2.5,"publicationDate":"2023-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10331031/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10172009","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Erratum: A Genomic Approach to Identify the Difference between Acute and Chronic UVB Exposures in the Causation of Inflammation and Cancer. 勘误:鉴定急性和慢性UVB暴露在炎症和癌症病因中的差异的基因组方法。

IF 2.5

Journal of Cancer Prevention Pub Date : 2023-03-30 DOI: 10.15430/JCP.2023.28.1.29

JunPyo Han, Yujin Jang, Dong Yeop Shin, Jun Lee, Young Rok Seo

引用次数: 0

Effects of Exhaustive Exercise on Inflammatory, Apoptotic, and Antioxidative Signaling Pathways in Human Peripheral Blood Mononuclear Cells. 力竭运动对人外周血单核细胞炎症、凋亡和抗氧化信号通路的影响。

IF 2.5

Journal of Cancer Prevention Pub Date : 2023-03-30 DOI: 10.15430/JCP.2023.28.1.3

Si-Young Kim, Young-Joon Surh, Young-Soo Lee

{"title":"Effects of Exhaustive Exercise on Inflammatory, Apoptotic, and Antioxidative Signaling Pathways in Human Peripheral Blood Mononuclear Cells.","authors":"Si-Young Kim, Young-Joon Surh, Young-Soo Lee","doi":"10.15430/JCP.2023.28.1.3","DOIUrl":"https://doi.org/10.15430/JCP.2023.28.1.3","url":null,"abstract":"In the present study, we investigated the effects of exhaustive exercise and recovery on inflammatory, pro-apoptotic, and anti-oxidative responses in human peripheral blood mononuclear cells (PBMCs). Sixteen volunteers participated in a guided physical activity program in which they were subjected to progressive exercise on the treadmill until they were exhausted followed by an 1-hour recovery period. Isolated human PBMCs were collected before exercise, immediately after exercise, and after 1-hour recovery. Exhaustive exercise induced expression of heme oxygenase-1 and glutamate cysteine ligase catalytic subunit and activation of NF-κB and NF-E2 related factor 2 (Nrf2). Apoptosis, as measured by activity and cleavage of caspase-3 and its substrate PARP also significantly increased. However, induction of redox signaling and the pro-apoptotic response fully returned to the baseline level during the 1-hour recovery period. On the other hand, COX-2 expression was continuously elevated after exercise cessation throughout the 1-hour recovery period. Taking all these findings into account, we conclude that exhaustive exercise transiently induces Nrf2-mediated antioxidant gene expression and eliminates damaged cells through apoptosis as part of an adaptive cytoprotective response against oxidative and inflammatory stress.","PeriodicalId":15120,"journal":{"name":"Journal of Cancer Prevention","volume":"28 1","pages":"3-11"},"PeriodicalIF":2.5,"publicationDate":"2023-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/d2/bf/jcp-28-1-3.PMC10080013.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9283515","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Emerging Trends in Cancer Prevention Agent Development. 癌症预防剂发展的新趋势。

IF 2.5

Journal of Cancer Prevention Pub Date : 2023-03-30 DOI: 10.15430/JCP.2023.28.1.24

Mark Steven Miller, Altaf Mohammed

{"title":"Emerging Trends in Cancer Prevention Agent Development.","authors":"Mark Steven Miller, Altaf Mohammed","doi":"10.15430/JCP.2023.28.1.24","DOIUrl":"https://doi.org/10.15430/JCP.2023.28.1.24","url":null,"abstract":"Advances in omics and immunology over the past 20 years have revolutionized the approach to cancer prevention, with the goal now focused on identifying populations at higher risk for developing cancer in their lifetime as a result of either extensive exposure to environmental carcinogens or harboring precancer lesions or inherited genetic mutations that predispose them to specific types of cancer(s). Thus, the naïve idea that cancer could be \"prevented\" in the general population has evolved to a more practical approach based on the understanding that the target population for preventive agents will be individuals who already have alterations, in gene pathways, whether inherited or environmentally caused, and the goal will be to \"intercept\" these lesions at the earliest stages in the path from an initial genetic lesion to full-blown cancer. The Division of Cancer Prevention of the National Cancer Institute and the Office of Disease Prevention at the National Institutes of Health recently sponsored the second biennial \"Translational Advances in Cancer Preventive Agent Development Meeting,\" held virtually from September 7-9th. In this Meeting Report, we highlight the scientific sessions of this meeting that covered the most recent advances in preventive agent development that also highlighted these rapidly emerging trends in this research area.","PeriodicalId":15120,"journal":{"name":"Journal of Cancer Prevention","volume":"28 1","pages":"24-28"},"PeriodicalIF":2.5,"publicationDate":"2023-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/8c/b3/jcp-28-1-24.PMC10080017.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9277951","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Black Tea Extract, via Modulation of TGF-β Pathway, Prevents Inorganic Arsenic-induced Development of Squamous Cell Carcinoma of the Skin in Swiss Albino Mice. 红茶提取物通过调节TGF-β通路阻止无机砷诱导的瑞士白化小鼠皮肤鳞状细胞癌的发生。

IF 2.5

Journal of Cancer Prevention Pub Date : 2023-03-30 DOI: 10.15430/JCP.2023.28.1.12

Archismaan Ghosh, Madhumita Roy

{"title":"Black Tea Extract, via Modulation of TGF-β Pathway, Prevents Inorganic Arsenic-induced Development of Squamous Cell Carcinoma of the Skin in Swiss Albino Mice.","authors":"Archismaan Ghosh, Madhumita Roy","doi":"10.15430/JCP.2023.28.1.12","DOIUrl":"https://doi.org/10.15430/JCP.2023.28.1.12","url":null,"abstract":"Chronic exposure to inorganic arsenic (iAs) elevates reactive oxygen species (ROS) generation and up-regulates TGF-β signalling. This promotes induction of epithelial to mesenchymal transition (EMT) and causes the development of squamous cell carcinoma (SCC) of skin. Black tea is a popular beverage worldwide and an effective antioxidant. Chemopreventive potential of black tea extract (BTE) against iAs induced carcinogenicity has been explored here. The study aims to investigate the role of BTE in prevention of iAs-induced SCC of skin in Swiss albino mice via the modulation of TGF-β signalling and EMT. Mice were divided into (1) control, (2) iAs, (3) iAs+BTE, and (4) BTE groups and were administered iAs and BTE alone, or in combination for 330 days. Histological studies were performed to assess development of SCC. ROS generation was estimated by flowcytometry. Expression of TGF-β and downstream proteins belonging to suppressor of mothers against decapentaplegic (Smad), phosphoinositide-3-kinase (PI3K)-protein kinase B (AKT) and mitogen-activated protein kinase (MAPK) pathways was assessed by immunoblotting. Expression of EMT markers was evaluated by immunoblotting, immunohistochemistry and semi-quantitative reverse transcriptase-PCR. After 330 days of iAs treatment, development of invasive SCC of skin probably due to excess ROS generation, elevation of TGF-β, downregulation of the Smad pathway, upregulation of PI3K-AKT and MAPK signalling molecules and induction of EMT was observed. All these modulations were found to be reversed by BTE, which inhibits iAs induced SCC of skin by quenching excess ROS, promoting Smad mediated TGF-β signalling, downregulating signalling intermediates of PI3K-AKT and MAPK pathways and inhibiting EMT.","PeriodicalId":15120,"journal":{"name":"Journal of Cancer Prevention","volume":"28 1","pages":"12-23"},"PeriodicalIF":2.5,"publicationDate":"2023-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/fb/62/jcp-28-1-12.PMC10080015.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9277953","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0