Journal of Bone and Mineral Metabolism最新文献_第6页

Correlation between serum high-density lipoprotein cholesterol and bone mineral density in vitamin D-deficient populations. 维生素d缺乏人群血清高密度脂蛋白胆固醇与骨密度的相关性

IF 2.4 3区医学

Journal of Bone and Mineral Metabolism Pub Date : 2025-03-01 Epub Date: 2025-01-15 DOI: 10.1007/s00774-024-01572-w

Miaomiao An, Chunyan Wu, Shaohui Feng, Lingyan Zhu, Wanli Yang, Limei Ran, Lin Yang, Laigang Zhao

{"title":"Correlation between serum high-density lipoprotein cholesterol and bone mineral density in vitamin D-deficient populations.","authors":"Miaomiao An, Chunyan Wu, Shaohui Feng, Lingyan Zhu, Wanli Yang, Limei Ran, Lin Yang, Laigang Zhao","doi":"10.1007/s00774-024-01572-w","DOIUrl":"10.1007/s00774-024-01572-w","url":null,"abstract":"Introduction: To investigate the relationship between serum high-density lipoprotein (HDL) cholesterol and bone mineral density (BMD) in vitamin D-deficient population.Materials and methods: This study was a cross-sectional study. From January to December 2020, 2583 middle-aged and older adult aged 40 and above were randomly selected in the Health Management Center of the Affiliated Hospital of Guizhou Medical University for health examination and questionnaire survey. The correlation was determined by Pearson correlation method, and the independent correlation was analyzed by multiple linear regression. The receiver Operating characteristic (ROC) curve estimates HDL-C cutoff levels for predicting osteoporosis risk.Results: The prevalence of osteoporosis in the study population was 11.4%, the overall prevalence of 25 (OH) D deficiency was 78.2%. There was no correlation between HDL-C and BMD of lumbar spine, femoral neck and total hip in normal vitamin D group (P > 0.05). HDL-C in the deficient group was negatively correlated with BMD of lumbar spine and femoral neck (P < 0.05), but not with BMD of total hip. Serum HDL-C concentration increased with the progression of osteoporosis. When serum 25 (OH) D level was lower than normal level, HDL-C ≥ 1.215 mmol/L was an independent predictor of osteoporosis (sensitivity = 75%, specificity = 53%, Area = 0.625).Conclusions: HDL-C was inversely associated with BMD in the lumbar spine and femoral neck in people aged 40 years and older with vitamin D deficiency. When serum HDL-C concentration ≥ 1.215 mmol/L, it can better predict the occurrence of osteoporosis.","PeriodicalId":15116,"journal":{"name":"Journal of Bone and Mineral Metabolism","volume":" ","pages":"174-181"},"PeriodicalIF":2.4,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143005928","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Accelerated bone loss in late reproductive-aged and perimenopausal women with vitamin D insufficiency. 生殖年龄晚期和围绝经期妇女维生素 D 不足会加速骨质流失。

IF 2.4 3区医学

Journal of Bone and Mineral Metabolism Pub Date : 2025-03-01 Epub Date: 2024-09-30 DOI: 10.1007/s00774-024-01556-w

Min-Jeong Kim, Sunmie Kim, Jin Ju Kim, Kyung Hee Han

{"title":"Accelerated bone loss in late reproductive-aged and perimenopausal women with vitamin D insufficiency.","authors":"Min-Jeong Kim, Sunmie Kim, Jin Ju Kim, Kyung Hee Han","doi":"10.1007/s00774-024-01556-w","DOIUrl":"10.1007/s00774-024-01556-w","url":null,"abstract":"Introduction: The association between serum vitamin D levels and bone mineral density (BMD) varies by race and gender. This study aimed to evaluate this relationship between serum vitamin D levels and BMD, and changes of BMD over time in Korean women.Materials and methods: We analyzed data from 586 generally healthy Korean women aged 29-79 who underwent health check-ups at Seoul National University Gangnam Center between 2010 and 2011 (baseline measurement) and 2015-2016 (follow-up). Dual energy X-ray absorptiometry (DEXA) and serum 25-hydroxyvitamin D (25OH-D) level measurements were conducted. We assessed the association between serum 25OH-D levels and BMD, as well as changes in BMD over time.Results: The mean age of participants was 51.3 ± 7.9 years, with a mean follow-up interval of 4.6 ± 0.7 years, and mean serum 25OH-D level of 20.6 ± 8.5 ng/ml. Baseline serum 25OH-D levels did not correlate with BMD values at the lumbar spine, femoral neck, or total femur, nor with changes in BMD over time. A significant negative association was found between perimenopausal status and BMD changes at all sites, and between premenopausal status and lumbar bone mass, compared to postmenopausal status in the 25OH-D < 20 ng/ml group. This association was not observed in women with higher serum 25OH-D levels.Conclusions: Serum 25OH-D levels did not correlate with BMD levels or changes in BMD overall. However, in late reproductive-aged and perimenopausal women with serum 25OH-D insufficiency, there was a significant association with accelerated bone loss.","PeriodicalId":15116,"journal":{"name":"Journal of Bone and Mineral Metabolism","volume":" ","pages":"86-95"},"PeriodicalIF":2.4,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142347226","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Nutrient foramina of human fibula: morphometric analysis and clinical relevance. 人腓骨营养孔：形态计量学分析及其临床意义。

IF 2.4 3区医学

Journal of Bone and Mineral Metabolism Pub Date : 2025-03-01 Epub Date: 2024-12-02 DOI: 10.1007/s00774-024-01568-6

N Roshini, Maria Francis Yuvaraj, Sankaran Ponnusamy Kasirajan, Balaji Karunakaran, Lakshmanan Govindan, John T D Caleb, Azhagu Madhavan Sivalingam, T Siva, Sathish Kumar

{"title":"Nutrient foramina of human fibula: morphometric analysis and clinical relevance.","authors":"N Roshini, Maria Francis Yuvaraj, Sankaran Ponnusamy Kasirajan, Balaji Karunakaran, Lakshmanan Govindan, John T D Caleb, Azhagu Madhavan Sivalingam, T Siva, Sathish Kumar","doi":"10.1007/s00774-024-01568-6","DOIUrl":"10.1007/s00774-024-01568-6","url":null,"abstract":"Background: The fibula, situated laterally in the leg, receives vital nutrition through nutrient arteries during embryonic bone growth and early ossification. This study aims to assess the direction, distance, location, number, and foraminal index of nutrient foramina in dry fibulae from the South Indian population.Materials and methods: A descriptive cross-sectional analysis involved 63 dry adult human fibulae sourced from the Department of Anatomy, Saveetha Medical College and Hospital, Thandalam. Parameters like fibula length, location, number, and direction of vascular foramina were recorded. Statistical analyses were performed on morphometric data and foraminal index.Results: The mean fibula length was 34.68 ± 2.11 cm. Among the fibulae, 88.88% had a single nutrient foramen, 4.76% had dual foramina, and 6.34% lacked nutrient foramina. Most single foramina were found on the medial crest (66.66%), followed by between the medial crest and posterior border (20.63%). Nutrient foramina were primarily located in Zone II (87.30%), followed by Zone III (11.11%) and Zone I (1.58%). Directionally, 85.71% pointed downward, while 14.28% pointed upward. The mean foraminal index was 40.85 ± 6.78, ranging from 32.57 to 56.25.Conclusion: Zone II, particularly on the medial crest, was the most prevalent location for vascular foramina in the fibula. Dual foramina occurred in 6.34% of cases. This precise anatomical knowledge is valuable for various medical professionals, including anthropologists, forensic experts, radiologists, plastic surgeons, and orthopedic surgeons, especially in procedures involving vascularized fibular bone grafts.","PeriodicalId":15116,"journal":{"name":"Journal of Bone and Mineral Metabolism","volume":" ","pages":"149-157"},"PeriodicalIF":2.4,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142769204","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Assessment of evidence for the off-label application of osteoanabolic drugs in fracture healing and spinal fusion. 骨合成代谢药物在骨折愈合和脊柱融合中的超适应症应用证据评估。

IF 2.4 3区医学

Journal of Bone and Mineral Metabolism Pub Date : 2025-03-01 Epub Date: 2025-02-18 DOI: 10.1007/s00774-025-01589-9

Hiroshi Kawaguchi

{"title":"Assessment of evidence for the off-label application of osteoanabolic drugs in fracture healing and spinal fusion.","authors":"Hiroshi Kawaguchi","doi":"10.1007/s00774-025-01589-9","DOIUrl":"10.1007/s00774-025-01589-9","url":null,"abstract":"Osteoanabolic drugs are sometimes prescribed off-label for \"fracture healing and spinal fusion.\" This study examines the scientific validity of such practices by analyzing existing clinical reports. The purported bone union-promoting effect of teriparatide in fracture cases has been refuted in clinical trials. While teriparatide shows efficacy in accelerating spinal fusion after surgery for patients with osteoporosis, there is no scientific justification for its off-label use in patients without osteoporosis. For osteoporosis patients, no clear evidence suggests that teriparatide is superior to antiresorptive drugs, making the rationale for switching from antiresorptive drugs to teriparatide weak. The efficacy in postoperative spinal fusion may primarily be attributed to systemic improvements in bone quality and quantity, enhancing the mechanical engagement of implants. The clinical evidence for the off-label use of romosozumab, another osteoanabolic drug, in fracture healing and spinal fusion is insufficient to support its efficacy. In conclusion, osteoanabolic drugs, like antiresorptive drugs, primarily have systemic functions in osteoporosis patients, with limited evidence supporting their role in promoting localized bone formation in fractures or spinal fusions.","PeriodicalId":15116,"journal":{"name":"Journal of Bone and Mineral Metabolism","volume":" ","pages":"57-60"},"PeriodicalIF":2.4,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143440788","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Multiple thyroid disorders and risk of osteoporosis: a two-sample Mendelian randomization study. 多发性甲状腺疾病和骨质疏松的风险：一项双样本孟德尔随机研究。

IF 2.4 3区医学

Journal of Bone and Mineral Metabolism Pub Date : 2025-03-01 Epub Date: 2024-12-06 DOI: 10.1007/s00774-024-01559-7

Guang Shi, Zhao Lin, Qixiao Shen, Wei Jin, Zhuowen Hao, Junwu Wang, Tianhong Chen, Jiayao Chen, Xin Wang, Jingfeng Li

{"title":"Multiple thyroid disorders and risk of osteoporosis: a two-sample Mendelian randomization study.","authors":"Guang Shi, Zhao Lin, Qixiao Shen, Wei Jin, Zhuowen Hao, Junwu Wang, Tianhong Chen, Jiayao Chen, Xin Wang, Jingfeng Li","doi":"10.1007/s00774-024-01559-7","DOIUrl":"10.1007/s00774-024-01559-7","url":null,"abstract":"Introduction: Previous research has demonstrated that even minor changes in thyroid function are associated with an increased risk of osteoporosis (OP). However, the causal relationship between thyroid disorders and the development of OP remains unclear. To address this, we aim to investigate the connection between genetic predispositions to various thyroid disorders and OP using a two-sample Mendelian randomization (MR) approach.Materials and methods: Instrumental variables (IVs) for multiple thyroid disorders were sourced from a large genome-wide association study (GWAS) meta-analysis dataset. Summary-level data for OP were obtained from the FinnGen consortium. Inverse variance weighting (IVW) methods served as the primary approach for MR analysis. Sensitivity analyses included MR-Egger regression, heterogeneity testing, multiple validity tests, and leaFve-one-out sensitivity tests.Results: IVW analysis revealed a direct causal effect of hypothyroidism (OR = 1.105, 95% CI 1.023-1.194, P 0.011) and Hashimoto's thyroiditis (OR = 1.142, 95% CI 1.026-1.271, P 0.015) on OP. However, no direct causal association was found between hyperthyroidism (OR = 1.030, 95% CI 0.944-1.123, P 0.508) or thyroid cancer (OR = 0.971, 95% CI 0.898-1.051, P 0.469) and OP.Conclusion: Our MR analysis revealed a causal association between hypothyroidism, Hashimoto's thyroiditis, and OP. This highlights the significant impact of thyroid function on bone health. However, further longitudinal studies are needed to confirm these findings conclusively.","PeriodicalId":15116,"journal":{"name":"Journal of Bone and Mineral Metabolism","volume":" ","pages":"96-107"},"PeriodicalIF":2.4,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142785742","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Association between the Sp1-binding-site polymorphism in the collagen type I alpha 1 (COLIA1) gene and bone phenotypes: the Dubbo Osteoporosis Epidemiology Study. I 型胶原蛋白 alpha 1 (COLIA1) 基因中 Sp1 结合位点多态性与骨表型之间的关系：杜伯骨质疏松症流行病学研究。

IF 2.4 3区医学

Journal of Bone and Mineral Metabolism Pub Date : 2025-03-01 Epub Date: 2024-11-06 DOI: 10.1007/s00774-024-01558-8

Ngoc Huynh, Krisel De Dios, Thach S Tran, Jacqueline R Center, Tuan V Nguyen

{"title":"Association between the Sp1-binding-site polymorphism in the collagen type I alpha 1 (COLIA1) gene and bone phenotypes: the Dubbo Osteoporosis Epidemiology Study.","authors":"Ngoc Huynh, Krisel De Dios, Thach S Tran, Jacqueline R Center, Tuan V Nguyen","doi":"10.1007/s00774-024-01558-8","DOIUrl":"10.1007/s00774-024-01558-8","url":null,"abstract":"Introduction: Polymorphisms within the collagen 1 alpha 1 gene (COLIA1) have been shown to be associated with bone mineral density (BMD). This study aimed to test the hypothesis that COLIA1 polymorphisms are associated with bone loss and fragility fractures.Materials and methods: The study involved 809 postmenopausal women aged 60 years and above in the Dubbo Osteoporosis Epidemiology Study who had COLIA1 genotypes and at least two BMD measurements over a 30-year period. BMD at the lumbar spine (LSBMD) and femoral neck (FNBMD) was measured biennially by dual-energy X-ray absorptiometry (GE-Lunar Prodigy). Fragility fracture has been ascertained by X-ray reports between 1990 and 2020. The G-> T polymorphism at the Sp1-binding site in the COLIA1 gene (rs1800012) was determined by the PCR-based method, and coded as GG, GT, and TT.Results: Women homozygous for the minor allele (TT) tended to have greater bone loss (-0.72%/year) than those with GT (-0.58%/year) or GG (-0.56%/year) though the difference did not achieve statistical significance (P = 0.84). Women of the TT genotype were associated with a two-fold greater risk of any fracture (adjusted hazard ratio: 2.21; 95%CI 1.42-3.46) and almost fourfold greater risk of hip fracture (3.78; 1.83-7.82) than those with either GG or GT genotype.Conclusions: Polymorphisms at the Sp1 site in the COLIA1 gene are associated with fracture risk, independent of bone loss.","PeriodicalId":15116,"journal":{"name":"Journal of Bone and Mineral Metabolism","volume":" ","pages":"114-122"},"PeriodicalIF":2.4,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142590650","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Sequential therapy following teriparatide treatment in patients at high risk of osteoporotic patients. 高危骨质疏松患者特立帕肽治疗后序贯治疗。

IF 2.4 3区医学

Journal of Bone and Mineral Metabolism Pub Date : 2025-01-01 Epub Date: 2025-03-22 DOI: 10.1007/s00774-025-01584-0

Satoshi Mori

引用次数: 0

Bone development by Hedgehog and Wnt signaling, Runx2, and Sp7. 通过刺猬和 Wnt 信号、Runx2 和 Sp7 实现骨骼发育。

IF 2.4 3区医学

Journal of Bone and Mineral Metabolism Pub Date : 2025-01-01 Epub Date: 2024-10-01 DOI: 10.1007/s00774-024-01551-1

Toshihisa Komori

{"title":"Bone development by Hedgehog and Wnt signaling, Runx2, and Sp7.","authors":"Toshihisa Komori","doi":"10.1007/s00774-024-01551-1","DOIUrl":"10.1007/s00774-024-01551-1","url":null,"abstract":"Hedgehog and canonical Wnt signaling pathways and the transcription factors Runx2 and Sp7 are essential for osteoblast differentiation. Ihh is necessary for the commitment of perichondrial mesenchymal cells to Runx2+ osteoprogenitors and for the formation of the bone collar and primary spongiosa. Runx2 is needed for osteoblast differentiation during both endochondral and intramembranous ossification. It regulates the commitment of mesenchymal cells to osteoblast-lineage cells and their proliferation by inducing the expression of Hedgehog, Fgf, Wnt, Pthlh signaling pathway genes, and Dlx5. The Runx2-induced expression of Fgfr2 and Fgfr3 is important for the proliferation of osteoblast-lineage cells. Runx2 induces Sp7 expression and Runx2+ osteoprogenitors become Runx2+Sp7+ preosteoblasts. Runx2, Sp7, and canonical Wnt signaling induce the differentiation of preosteoblasts into osteoblasts. Canonical Wnt signaling, but not Sp7, enhances the proliferation of osteoblast-lineage cells. In mature osteoblasts, Runx2 plays an important role in the expression of major bone matrix protein genes, including Col1a1, Col1a2, Spp1, Ibsp, and Bglap/Bglap2. The canonical Wnt signaling pathway is also crucial for bone formation by mature osteoblasts. Sp7 is needed for osteocytes to acquire a sufficient number of processes and a reduction in these processes results in osteocyte apoptosis and cortical porosity.","PeriodicalId":15116,"journal":{"name":"Journal of Bone and Mineral Metabolism","volume":" ","pages":"33-38"},"PeriodicalIF":2.4,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142347227","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Histological assessments for anabolic effects in teriparatide/abaloparatide administered rodent models. 特立帕肽/阿巴帕肽给药啮齿动物模型合成代谢作用的组织学评估。

IF 2.4 3区医学

Journal of Bone and Mineral Metabolism Pub Date : 2025-01-01 Epub Date: 2024-12-04 DOI: 10.1007/s00774-024-01562-y

Tomoka Hasegawa, Tomomaya Yamamoto, Mai Haraguchi-Kitakamae, Hiromi Hongo, Yan Shi, Jiaxin Cui, Xuanyu Liu, Qi Yao, Miki Abe, Haruhi Maruoka, Ayako Yokoyama, Tamaki Sekiguchi, Akito Makino, Norio Amizuka

{"title":"Histological assessments for anabolic effects in teriparatide/abaloparatide administered rodent models.","authors":"Tomoka Hasegawa, Tomomaya Yamamoto, Mai Haraguchi-Kitakamae, Hiromi Hongo, Yan Shi, Jiaxin Cui, Xuanyu Liu, Qi Yao, Miki Abe, Haruhi Maruoka, Ayako Yokoyama, Tamaki Sekiguchi, Akito Makino, Norio Amizuka","doi":"10.1007/s00774-024-01562-y","DOIUrl":"10.1007/s00774-024-01562-y","url":null,"abstract":"Parathyroid hormone (PTH) is thought to induce remodeling-based bone formation by promoting osteoclastic activity, a process known as cellular coupling. Our research has shown that the frequency of PTH administration affects trabecular number and thickness. High-frequency PTH administration induced remodeling-based bone formation, while less frequent administration induced both remodeling-based and modeling-based bone formation. Additionally, we found that specific bone sites influence whether remodeling-based or modeling-based bone formation is more likely to occur. Additionally, while PTH significantly increases trabecular bone, it also causes cortical porosis. Our research on the femoral diaphysis showed that PTH administration resulted in the invasion of blood vessels and osteoclasts into the cortical bone. Abaloparatide acts similarly to teriparatide through the parathyroid hormone receptor type 1 (PTH1R) but may have a wider anabolic window due to its lesser impact on bone resorption. Our mouse studies with abaloparatide showed similar results to those seen in human patients, with increased preosteoblastic cell populations and wider anabolic windows when compared with teriparatide. Abaloparatide-induced bone formation cannot be explained solely by remodeling-based bone formation, indicating the need for further research into modeling-based bone formation.","PeriodicalId":15116,"journal":{"name":"Journal of Bone and Mineral Metabolism","volume":" ","pages":"46-56"},"PeriodicalIF":2.4,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142769268","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Responders and non-responders to romosozumab treatment. 对罗莫索单抗治疗有反应和无反应。

IF 2.4 3区医学

Journal of Bone and Mineral Metabolism Pub Date : 2025-01-01 Epub Date: 2024-12-07 DOI: 10.1007/s00774-024-01570-y

Ayako Tominaga, Keiji Wada, Yoshiharu Kato, Ken Okazaki

{"title":"Responders and non-responders to romosozumab treatment.","authors":"Ayako Tominaga, Keiji Wada, Yoshiharu Kato, Ken Okazaki","doi":"10.1007/s00774-024-01570-y","DOIUrl":"10.1007/s00774-024-01570-y","url":null,"abstract":"Introduction: Romosozumab is an anti-sclerostin antibody drug with potent bone formation-promoting and bone resorption-inhibiting properties. It enhances bone mineral density and has a novel effect in preventing fractures. However, there have been reports of non-responders to romosozumab.Findings: If the least significant change is defined as 3%, only 2-12% of patients with spine osteoporosis are non-responders, and romosozumab is highly effective in this population. Low-type 1 amino-terminal propeptide (P1NP) levels during the early treatment phase are associated with non-responders early in treatment. The researchers found a cutoff value of 50.3 μg/L of P1NP in the first month of treatment. In contrast, hip osteoporosis does not respond (54-57% of the time). Low P1NP levels at the start of treatment increase the risk of non-responders. The cutoff value for P1NP was reported as 53.7 μg/L at the beginning of treatment. However, failure to meet these cutoff values does not necessarily indicate that the patient is a non-responder and does not justify a change in drug administration.Conclusions: In spine osteoporosis, romosozumab demonstrates high effectiveness, with approximately 2-12% of patients showing no response. However, in hip osteoporosis, approximately 54-57% do not respond to the treatment with romosozumab.","PeriodicalId":15116,"journal":{"name":"Journal of Bone and Mineral Metabolism","volume":" ","pages":"18-21"},"PeriodicalIF":2.4,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142791732","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0