Journal of Bone and Mineral Metabolism最新文献

{"title":"Response to the letter regarding \"Postoperative risks of type 2 diabetes in elderly hip fracture patients: a propensity score-matched study\".","authors":"Yu Mori, Kunio Tarasawa, Hidetatsu Tanaka, Naoko Mori, Kiyohide Fushimi, Toshimi Aizawa, Kenji Fujimori","doi":"10.1007/s00774-025-01681-0","DOIUrl":"10.1007/s00774-025-01681-0","url":null,"abstract":"","PeriodicalId":15116,"journal":{"name":"Journal of Bone and Mineral Metabolism","volume":" ","pages":"546-547"},"PeriodicalIF":2.9,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146010593","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Response to the comment on: \"Trolox, r-irisin and resveratrol cocktail to counteract osteoblast metabolism alterations in osteoarthritis and osteoporosis\"-proposal to validate cocktail efficacy in female osteoblasts.","authors":"Roberto Bonanni, Angela Falvino, Amarildo Smakaj, Lucia Tranquillo, Anna Maria Rinaldi, Giovanna D'Arcangelo, Pierangelo Cifelli, Virginia Tancredi, Ida Cariati, Umberto Tarantino","doi":"10.1007/s00774-026-01691-6","DOIUrl":"10.1007/s00774-026-01691-6","url":null,"abstract":"","PeriodicalId":15116,"journal":{"name":"Journal of Bone and Mineral Metabolism","volume":" ","pages":"550-551"},"PeriodicalIF":2.9,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146137281","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Response to the letter to the editor regarding \"treatment with romosozumab in patients with osteoporosis on maintenance hemodialysis\".","authors":"Motohiko Sato","doi":"10.1007/s00774-026-01712-4","DOIUrl":"10.1007/s00774-026-01712-4","url":null,"abstract":"","PeriodicalId":15116,"journal":{"name":"Journal of Bone and Mineral Metabolism","volume":" ","pages":"561"},"PeriodicalIF":2.9,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147504026","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Imaging-based stratification of marginal versus segmental mandibulectomy in MRONJ.","authors":"Yuka Kojima, Shunsuke Sawada, Yuki Sakamoto","doi":"10.1007/s00774-026-01730-2","DOIUrl":"10.1007/s00774-026-01730-2","url":null,"abstract":"<p><strong>Introduction: </strong>Medication-related osteonecrosis of the jaw (MRONJ) is a serious complication of antiresorptive therapy. Although surgical intervention is increasingly recommended, the optimal extent of mandibular resection-particularly indications for marginal versus segmental mandibulectomy-remains controversial. Conventional staging systems may not capture qualitative CT patterns that could be associated with surgical outcomes.</p><p><strong>Materials and methods: </strong>This retrospective observational study included 76 patients with mandibular MRONJ who underwent surgical treatment between January 2018 and March 2024. Preoperative computed tomography (CT) images were evaluated for osteolysis, periosteal reaction, and osteosclerosis, and lesions were classified into three imaging-based types (A-C). Treatment outcomes and prognostic factors were analyzed separately for marginal and segmental mandibulectomy.</p><p><strong>Results: </strong>Marginal mandibulectomy was performed in 46 patients and segmental mandibulectomy in 30 patients. Healing was achieved in 43.5% after marginal mandibulectomy and in 80.0% after segmental mandibulectomy. In the marginal mandibulectomy group, higher imaging-based MRONJ types (Types B and C), denosumab use, malignancy, and absence of sequestrum separation were associated with lower healing rates. In contrast, in the segmental mandibulectomy group, younger age and periosteal reaction were associated with improved healing.</p><p><strong>Conclusions: </strong>This study suggests that radiological patterns of mandibular MRONJ are associated with surgical outcomes and may complement conventional staging. Although segmental mandibulectomy showed numerically higher healing, interpretation is limited by confounding by indication. CT-based imaging assessment may help anticipate the risk of delayed or incomplete healing after limited resection and support individualized selection of surgical extent. Future prospective studies incorporating standardized imaging evaluation and radiologic-pathologic correlation are warranted.</p>","PeriodicalId":15116,"journal":{"name":"Journal of Bone and Mineral Metabolism","volume":" ","pages":"513-520"},"PeriodicalIF":2.9,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147815264","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of pregnancy and lactation-associated osteoporosis on children: analysis using linked mother and child data.","authors":"Kyoko Kasahara, Shunichiro Tsuji, Taku Kawasaki, Takashi Murakami","doi":"10.1007/s00774-026-01720-4","DOIUrl":"10.1007/s00774-026-01720-4","url":null,"abstract":"<p><strong>Introduction: </strong>The health status of children born to mothers with pregnancy and lactation-associated osteoporosis (PLO) and impaired bone homeostasis remains unknown. This study aimed to investigate the effects of maternal PLO on child health, the PLO-predisposing factors related to such effects, and the incidence of the condition.</p><p><strong>Materials and methods: </strong>From a claims dataset comprising 172,730 mothers linked with their 210,124 children, mothers who developed fragility fractures between 5 months before and 12 months after delivery, along with their children, were defined as the PLO group. Healthy controls were randomly selected by matching maternal age and child sex. Body mass index (BMI), drug use, and maternal and pediatric diseases were compared between the two groups.</p><p><strong>Results: </strong>Fifty-nine mothers and 65 children were included in the PLO group, and 11,556 mothers and 11,664 children served as the control group. The most common PLO fracture was a vertebral fracture, and delayed diagnosis was common. Maternal PLO had few adverse effects on child health. There were trends toward a higher frequency of birth asphyxia in singletons (P = 0.072) and low birth weight in twins (P = 0.070) in the case children, but with no significant differences. The incidence of PLO was estimated at 374 per million deliveries. Multiple delivery, maternal age ≥ 40 years, low BMI, heparin use, and ovulation disorder were identified as predisposing factors for PLO.</p><p><strong>Conclusion: </strong>There is little evidence that maternal PLO adversely affects child health. The predisposing factors for PLO suggest that caution is warranted regarding current advancements in reproductive technology.</p>","PeriodicalId":15116,"journal":{"name":"Journal of Bone and Mineral Metabolism","volume":" ","pages":"501-512"},"PeriodicalIF":2.9,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13468983/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147662463","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Response to \"Revisiting Inflammaging: A Critical Appraisal of Its Role in Alveolar Bone Loss\".","authors":"Meircurius Dwi Condro Surboyo, Kridtapat Sirisereephap, Tomoki Maekawa","doi":"10.1007/s00774-026-01734-y","DOIUrl":"https://doi.org/10.1007/s00774-026-01734-y","url":null,"abstract":"","PeriodicalId":15116,"journal":{"name":"Journal of Bone and Mineral Metabolism","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2026-06-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148295182","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"24-month real-world persistence and compliance of denosumab versus alendronate among postmenopausal women with osteoporosis in Australia, Taiwan, South Korea, Hong Kong, and Singapore.","authors":"Tang Ching Lau, Dong-Gune Chang, Chung-Hwan Chen, Shuang Huang, Edith M C Lau, Sheung-Wai Law, Young-Kyun Lee, Cae Tolman, Laura Canals, See-Hwee Yeo, Peter R Ebeling","doi":"10.1007/s00774-026-01736-w","DOIUrl":"https://doi.org/10.1007/s00774-026-01736-w","url":null,"abstract":"<p><strong>Introduction: </strong>To compare 24-month persistence and compliance of denosumab with alendronate in postmenopausal women with osteoporosis across 5 Asia-Pacific territories.</p><p><strong>Materials and methods: </strong>This prospective cohort study included women aged ≥ 50 years from Australia, Taiwan, South Korea, Hong Kong, and Singapore. Participants received either a bi-annual denosumab injection or weekly oral alendronate as osteoporosis treatment, based on physician judgment. Multivariable logistic regression assessed whether therapy (denosumab or alendronate) was significantly associated with treatment persistence and compliance over 24 months of follow-up. The models were adjusted for age, fracture history, baseline bone mineral density (BMD), prior osteoporosis therapy, and prior oral glucocorticoid treatment. Adjusted odds ratios (aORs) and 95% confidence intervals (CIs) were calculated.</p><p><strong>Results: </strong>Among 687 enrolled patients, 549 completed their 24-month visit (295 in denosumab and 254 in alendronate group). Patients in the denosumab group were older and a higher proportion previously received osteoporosis treatment. Overall treatment persistence and compliance were 74.9% and 56.6%, respectively. Patients prescribed with denosumab exhibited higher persistence (86.1% vs. 61.8%; P < 0.001) and compliance (62.4% vs. 50.0%; P = 0.004), compared with those on alendronate. Regression results also demonstrated that patients receiving denosumab were more likely to be persistent (aOR = 3.91; 95% CI 2.52-6.08), and compliant (aOR = 1.61; 95% CI 1.12-2.31). BMD T-scores improved in both the treatment groups after 24 months with no significant association between treatment type and change in T-score. No significant difference was also observed in the occurrence of adverse events between the two treatment cohorts. Patients on alendronate reported gastrointestinal issues more frequently, whereas those on denosumab had a higher incidence of bone and joint injuries.</p><p><strong>Conclusion: </strong>Postmenopausal women with osteoporosis were more likely to be persistent and compliant with a bi-annual denosumab injection, compared with weekly oral alendronate.</p>","PeriodicalId":15116,"journal":{"name":"Journal of Bone and Mineral Metabolism","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2026-06-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148264579","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Eldecalcitol and calcium supplementation in Chinese women with postmenopausal osteoporosis: a prospective observational cohort study.","authors":"Yan Jiang, Yuhong Zeng, Li Xin, Wei Chen, Youjia Xu, Shoujin Tian, Qinglai Wang, Jianjun Li, Shihong Chen, Xuanxia Lin, Qifeng Ying, Shun Chiba, Chiemi Yamagiwa, Tomohiro Yamaguchi, Zheng Ke, Weibo Xia, Yasuhiro Takeuchi","doi":"10.1007/s00774-026-01735-x","DOIUrl":"10.1007/s00774-026-01735-x","url":null,"abstract":"<p><strong>Introduction: </strong>Eldecalcitol is an active vitamin D₃ derivative approved for the treatment of osteoporosis in Japan and postmenopausal osteoporosis in China. However, the impact of concomitant calcium supplementation on its safety profile is unclear.</p><p><strong>Materials and methods: </strong>This was a prospective, observational, non-interventional post-marketing drug intensive monitoring study in Chinese postmenopausal women with osteoporosis (NCT05433207). Data were collected using an electronic case report form at baseline, before initial eldecalcitol dosing, and during routine clinical visits over a 1-year follow-up period.</p><p><strong>Results: </strong>One thousand patients were enrolled from 29 Chinese clinical sites; 958 received eldecalcitol (853 without/105 with calcium supplementation). The mean age (standard deviation [SD]) of patients was 65.6 (9.0) years and mean (SD) time since osteoporosis diagnosis was 2.7 (3.8) years. Adverse drug reactions (ADRs) affected 39.2% and 42.9% of patients in the without and with calcium supplementation groups, respectively. 22 (2.3%) patients developed hypercalcemia including 17 (1.99%) and 5 (4.76%) in the without and with calcium supplementation groups, respectively. Multivariable logistic regression analyses indicated that those receiving calcium were more likely to experience hypercalcemia (adjusted odds ratio [OR] 3.07, 95% confidence interval [CI] 1.16, 8.10, P = 0.02) than those not receiving calcium. ADRs of urolithiasis were experienced by three patients (0.35%) in the without calcium supplementation group.</p><p><strong>Conclusion: </strong>This study confirmed the real-world safety profile of eldecalcitol in a large population of Chinese women with postmenopausal osteoporosis. Hypercalcemia incidence was higher in patients with compared to without calcium supplementation, indicating that concomitant eldecalcitol and calcium should be carefully considered.</p>","PeriodicalId":15116,"journal":{"name":"Journal of Bone and Mineral Metabolism","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2026-06-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148264539","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Marrow fatty acids in osteoporosis: metabolic insights, emerging therapeutic targets.","authors":"Mengyao Guo, Zeyang Miao, Run Xu, Peng Luo, Guanwu Li","doi":"10.1007/s00774-026-01737-9","DOIUrl":"https://doi.org/10.1007/s00774-026-01737-9","url":null,"abstract":"<p><strong>Purpose: </strong>This review examines the role of marrow adipose tissue fatty acid composition in skeletal homeostasis, focusing on osteoporosis. To avoid conceptual confusion, we define evidence tiers: human studies assessing endogenous marrow lipid profiles; mechanistic studies applying exogenous fatty acids in vitro and in vivo; indirect MRI-based surrogates of marrow fat quantity; and direct ex vivo measurements of fatty acid composition via GC-MS, LC-MS, and lipidomics. We also clarify the distinction between marrow fat quantity and fatty acid quality.</p><p><strong>Result: </strong>Human data reveal disease-, age-, and site-related alterations in marrow lipid saturation and unsaturation; however, findings vary by skeletal site, marrow compartment, fracture status, analytical platform, and study population. Experimental evidence demonstrates that saturated fatty acids (e.g., palmitic acid) induce lipotoxicity and osteoblast dysfunction, whereas unsaturated fatty acids (e.g., oleic acid and n-3 polyunsaturated fatty acids) exert protective effects via modulation of mesenchymal stem cell differentiation, osteoclastogenesis, ferroptosis, autophagy, and mitochondrial metabolism. Collectively, current evidence supports an association between marrow fatty acid biology and osteoporotic bone loss.</p><p><strong>Conclusion: </strong>Causal, diagnostic, and therapeutic implications remain preliminary. This review's main contribution is a fatty-acid-centered framework that integrates evidence tiers, molecular categories, and skeletal-site heterogeneity, guiding future research.</p>","PeriodicalId":15116,"journal":{"name":"Journal of Bone and Mineral Metabolism","volume":" ","pages":""},"PeriodicalIF":2.2,"publicationDate":"2026-06-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148251040","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Commentary on \"Incident subclinical vertebral fractures and health-related quality of life: JPOS cohort study\".","authors":"Binbin Xu","doi":"10.1007/s00774-026-01740-0","DOIUrl":"10.1007/s00774-026-01740-0","url":null,"abstract":"","PeriodicalId":15116,"journal":{"name":"Journal of Bone and Mineral Metabolism","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2026-06-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148251749","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}