Journal of Bone and Mineral Metabolism最新文献

{"title":"A comparative analysis of osteoporosis, nephrolithiasis, and metabolic/cardiovascular comorbidities in normocalcemic and mild primary hyperparathyroidism.","authors":"Mazhar Müslüm Tuna, İsmail Engin, Özden Uzun, Sevde Nur Fırat, Özge Kimyon, Elif Güneş, Kadircan Karatoprak, Ümit Nur Özbay, Ziynet Alphan Üç, Ali Yeşiltepe, Şevkican Güneş, Sayid Shafi Zuhur, Hüseyin Yağcı, Evin Bozkur, Özen Öz Gül, Ayten Oğuz, Cevdet Duran, Barış Güven Cansu, Nurdan Gül","doi":"10.1007/s00774-026-01732-0","DOIUrl":"https://doi.org/10.1007/s00774-026-01732-0","url":null,"abstract":"<p><strong>Introduction: </strong>Normocalcemic primary hyperparathyroidism (NPHPT) is thought to be an early form of hypercalcemic primary hyperparathyroidism (PHPT). However, some studies have shown that the adverse effects on bone and kidney health are similar in both conditions.</p><p><strong>Materials and methods: </strong>This is a nationwide, multicentre, retrospective study. Data from centres, including 404 patients with NPHPT and 723 patients with mild PHPT from different regions of Turkey, were included in this study. All laboratory parameters, dual-energy X-ray absorptiometry, and renal ultrasounds were performed locally at each centre. The prevalence of adverse bone and kidney outcomes and metabolic and cardiovascular comorbidities were the main outcome measures.</p><p><strong>Results: </strong>Patients with NPHPT had lower calcium and PTH levels. Skeletal outcomes revealed 29% osteoporosis and 42% osteopenia, while the prevalence of nephrolithiasis was 12.4%, which is similar to that observed in patients with mild PHPT. Hypertension was more prevalent in patients with mild PHPT than in those with NPHPT (44.4% vs. 34.9%, p = 0.002), as was diabetes mellitus (27.9% vs. 13.2%, p < 0.001). The prevalence of cardiovascular disease was similar (11.5% vs. 9.5%, p = 0.306).</p><p><strong>Conclusion: </strong>Patients with NPHPT experience significant skeletal complications and nephrolithiasis but have lower rates of hypertension and diabetes.</p>","PeriodicalId":15116,"journal":{"name":"Journal of Bone and Mineral Metabolism","volume":" ","pages":""},"PeriodicalIF":2.2,"publicationDate":"2026-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147863914","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Towards efficient osteoporosis screening: a simple and practical approach using OSTA and FRAX risk factors.","authors":"Chiaki Horii, Sakae Tanaka, Toshiko Iidaka, Saeko Fujiwara, Masayuki Iki, Yasushi Oshima, Shigeyuki Muraki, Hiroyuki Oka, Hiroshi Kawaguchi, Kozo Nakamura, Toru Akune, Noriko Yoshimura","doi":"10.1007/s00774-026-01729-9","DOIUrl":"https://doi.org/10.1007/s00774-026-01729-9","url":null,"abstract":"<p><strong>Introduction: </strong>Osteoporosis is a major public health concern, particularly in the aging population, where fragility fractures significantly impact quality of life and mortality. Despite the importance of early detection, screening rates for osteoporosis in Japan remain low. The Osteoporosis Self-Assessment Tool for Asians (OSTA) and Fracture Risk Assessment Tool (FRAX) are noninvasive screening tools. This study aimed to develop an efficient method for screening osteopenia using these tools.</p><p><strong>Materials and methods: </strong>We analyzed data from 1060 Japanese women aged 40-74 years from the Research on Osteoarthritis/Osteoporosis Against Disability (ROAD) study. The OSTA and FRAX scores, as well as individual FRAX risk factors, were assessed for their ability to detect osteopenia. As FRAX score calculations are not publicly available, we evaluated the discriminative ability of the seven risk factors individually. Prior fragility fractures were deemed the most critical, and all 64 possible combinations of the remaining six risk factors were analyzed.</p><p><strong>Results: </strong>OSTA had the highest discriminative ability (AUC = 0.81), followed by FRAX-Hip (AUC = 0.79) and FRAX-Major (AUC = 0.77). The sensitivity and specificity of OSTA ≤ -1 were 83.7% and 62.6%, respectively. The most effective criterion was OSTA ≤ -1 or at least one FRAX risk factor, achieving a sensitivity of 90.4%, specificity of 47.2%, and positive predictive value of 63.3%.</p><p><strong>Conclusion: </strong>A simple, noninvasive osteopenia screening method combining OSTA ≤ -1 and FRAX risk factors identified at-risk individuals effectively. This approach could enhance osteoporosis screening in Japan and facilitate early intervention and fracture prevention.</p>","PeriodicalId":15116,"journal":{"name":"Journal of Bone and Mineral Metabolism","volume":" ","pages":""},"PeriodicalIF":2.2,"publicationDate":"2026-05-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147815229","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"FLS shortens time to osteoporosis treatment and lowers 1-year refracture risk post proximal femoral fracture.","authors":"Masahito Taga, Kenji Hisa","doi":"10.1007/s00774-026-01731-1","DOIUrl":"https://doi.org/10.1007/s00774-026-01731-1","url":null,"abstract":"<p><strong>Introduction: </strong>Proximal femoral fractures are highly prevalent in Japan, with over 200,000 cases annually and a rising trend. Fracture liaison service (FLS) interventions improve osteoporosis treatment initiation and reduce refracture rates. The content of FLS interventions varies by institution, and the effectiveness of our intervention remains unclear. The aim of this study was to evaluate the effectiveness of our FLS intervention in preventing fragility fractures within 1 year after proximal femoral fracture surgery.</p><p><strong>Materials and methods: </strong>A retrospective case-control study was performed on patients aged ≥ 50 undergoing surgery for proximal femoral fracture between February 2021 and January 2024. Patients were divided into non-FLS (pre-August 2022) and FLS groups. Data including demographics, comorbidities, fracture type, medication initiation, and refracture occurrence within 1 year were extracted. Statistical analyses involved Mann-Whitney U, χ2 tests, and Cox proportional hazards modeling.</p><p><strong>Results: </strong>Among 521 eligible patients, osteoporosis medication initiation within 3 months improved from 14% in the non-FLS group to 100% in the FLS group (p < 0.05). Time to medication initiation decreased from 20 to 12 days (p < 0.05). The refracture rate was significantly lower in the FLS group (1.8% vs. 5.7%, p < 0.05). Multivariate analysis showed FLS intervention significantly reduced refracture risk (HR 0.32, 95% CI 0.12-0.89, p = 0.03) and robust in sensitivity analyses for cognition, walking ability, and discharge destination.</p><p><strong>Conclusions: </strong>FLS intervention effectively reduced fragility fractures within 1 year postoperatively by enhancing early osteoporosis treatment initiation. Continued FLS programs and long-term follow-up are recommended to sustain benefits.</p>","PeriodicalId":15116,"journal":{"name":"Journal of Bone and Mineral Metabolism","volume":" ","pages":""},"PeriodicalIF":2.2,"publicationDate":"2026-05-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147815214","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Imaging-based stratification of marginal versus segmental mandibulectomy in MRONJ.","authors":"Yuka Kojima, Shunsuke Sawada, Yuki Sakamoto","doi":"10.1007/s00774-026-01730-2","DOIUrl":"https://doi.org/10.1007/s00774-026-01730-2","url":null,"abstract":"<p><strong>Introduction: </strong>Medication-related osteonecrosis of the jaw (MRONJ) is a serious complication of antiresorptive therapy. Although surgical intervention is increasingly recommended, the optimal extent of mandibular resection-particularly indications for marginal versus segmental mandibulectomy-remains controversial. Conventional staging systems may not capture qualitative CT patterns that could be associated with surgical outcomes.</p><p><strong>Materials and methods: </strong>This retrospective observational study included 76 patients with mandibular MRONJ who underwent surgical treatment between January 2018 and March 2024. Preoperative computed tomography (CT) images were evaluated for osteolysis, periosteal reaction, and osteosclerosis, and lesions were classified into three imaging-based types (A-C). Treatment outcomes and prognostic factors were analyzed separately for marginal and segmental mandibulectomy.</p><p><strong>Results: </strong>Marginal mandibulectomy was performed in 46 patients and segmental mandibulectomy in 30 patients. Healing was achieved in 43.5% after marginal mandibulectomy and in 80.0% after segmental mandibulectomy. In the marginal mandibulectomy group, higher imaging-based MRONJ types (Types B and C), denosumab use, malignancy, and absence of sequestrum separation were associated with lower healing rates. In contrast, in the segmental mandibulectomy group, younger age and periosteal reaction were associated with improved healing.</p><p><strong>Conclusions: </strong>This study suggests that radiological patterns of mandibular MRONJ are associated with surgical outcomes and may complement conventional staging. Although segmental mandibulectomy showed numerically higher healing, interpretation is limited by confounding by indication. CT-based imaging assessment may help anticipate the risk of delayed or incomplete healing after limited resection and support individualized selection of surgical extent. Future prospective studies incorporating standardized imaging evaluation and radiologic-pathologic correlation are warranted.</p>","PeriodicalId":15116,"journal":{"name":"Journal of Bone and Mineral Metabolism","volume":" ","pages":""},"PeriodicalIF":2.2,"publicationDate":"2026-05-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147815264","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reply to: Comment on \"Bone fragility and atypical femoral fractures in SLE-role of disease activity, infection, and treatment\".","authors":"Hiroe Sato, Naoki Kondo, Tomoya Watarai, Eriko Hasegawa, Ayako Wakamatsu, Yukiko Nozawa, Daisuke Kobayashi, Takeshi Kuroda, Suguru Yamamoto","doi":"10.1007/s00774-026-01719-x","DOIUrl":"https://doi.org/10.1007/s00774-026-01719-x","url":null,"abstract":"","PeriodicalId":15116,"journal":{"name":"Journal of Bone and Mineral Metabolism","volume":" ","pages":""},"PeriodicalIF":2.2,"publicationDate":"2026-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147772343","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Response to comment on \"Assessing deep learning model performance in osteoporosis screening with lumbar spine radiographs\".","authors":"Artit Boonrod, Arunnit Boonrod","doi":"10.1007/s00774-026-01726-y","DOIUrl":"https://doi.org/10.1007/s00774-026-01726-y","url":null,"abstract":"","PeriodicalId":15116,"journal":{"name":"Journal of Bone and Mineral Metabolism","volume":" ","pages":""},"PeriodicalIF":2.2,"publicationDate":"2026-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147772290","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence and progression of hip osteoarthritis in individuals with diffuse idiopathic skeletal hyperostosis.","authors":"Masaya Kubota, Takayoshi Shimizu, Masaki Sakamoto, Masahiro Yakami, Takashi Sono, Ryusuke Nakamoto, Shuichi Matsuda, Bungo Otsuki","doi":"10.1007/s00774-026-01723-1","DOIUrl":"https://doi.org/10.1007/s00774-026-01723-1","url":null,"abstract":"<p><strong>Introduction: </strong>Diffuse idiopathic skeletal hyperostosis (DISH) primarily affects the axial skeleton, but its association with hip osteoarthritis (OA) remains unclear. We investigated the prevalence and 5 year progression of hip OA in individuals with DISH and explored risk factors for progression.</p><p><strong>Materials and methods: </strong>This retrospective cohort study reviewed 694 asymptomatic individuals who underwent whole-body computed tomography (CT) for cancer screening (2016-2023) and had follow-up CT at ≥ 5 years. DISH was diagnosed using CT-based criteria. We identified 143 individuals with DISH and selected 143 age- and sex-matched controls without DISH (1:1). Hip OA was assessed using a CT-based composite score (0-14, bilateral). Radiographic hip OA was defined as a bilateral score ≥ 10, and progression as an increase of ≥ 2 points over 5 years. Multivariable regression analyses were performed to identify independent predictors of progression.</p><p><strong>Results: </strong>The DISH group had higher total hip OA scores and a higher prevalence of radiographic hip OA than controls at baseline and follow-up. However, OA progression rates did not differ significantly between groups. Among individuals with DISH, the number of ankylosed vertebral segments was independently associated with hip OA progression.</p><p><strong>Conclusion: </strong>Individuals with DISH show a higher prevalence of radiographic hip OA. Extensive spinal ankylosis may increase the risk of hip OA progression, supporting the need for longitudinal monitoring of hip joint health in DISH.</p>","PeriodicalId":15116,"journal":{"name":"Journal of Bone and Mineral Metabolism","volume":" ","pages":""},"PeriodicalIF":2.2,"publicationDate":"2026-04-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147662507","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of pregnancy and lactation-associated osteoporosis on children: analysis using linked mother and child data.","authors":"Kyoko Kasahara, Shunichiro Tsuji, Taku Kawasaki, Takashi Murakami","doi":"10.1007/s00774-026-01720-4","DOIUrl":"https://doi.org/10.1007/s00774-026-01720-4","url":null,"abstract":"<p><strong>Introduction: </strong>The health status of children born to mothers with pregnancy and lactation-associated osteoporosis (PLO) and impaired bone homeostasis remains unknown. This study aimed to investigate the effects of maternal PLO on child health, the PLO-predisposing factors related to such effects, and the incidence of the condition.</p><p><strong>Materials and methods: </strong>From a claims dataset comprising 172,730 mothers linked with their 210,124 children, mothers who developed fragility fractures between 5 months before and 12 months after delivery, along with their children, were defined as the PLO group. Healthy controls were randomly selected by matching maternal age and child sex. Body mass index (BMI), drug use, and maternal and pediatric diseases were compared between the two groups.</p><p><strong>Results: </strong>Fifty-nine mothers and 65 children were included in the PLO group, and 11,556 mothers and 11,664 children served as the control group. The most common PLO fracture was a vertebral fracture, and delayed diagnosis was common. Maternal PLO had few adverse effects on child health. There were trends toward a higher frequency of birth asphyxia in singletons (P = 0.072) and low birth weight in twins (P = 0.070) in the case children, but with no significant differences. The incidence of PLO was estimated at 374 per million deliveries. Multiple delivery, maternal age ≥ 40 years, low BMI, heparin use, and ovulation disorder were identified as predisposing factors for PLO.</p><p><strong>Conclusion: </strong>There is little evidence that maternal PLO adversely affects child health. The predisposing factors for PLO suggest that caution is warranted regarding current advancements in reproductive technology.</p>","PeriodicalId":15116,"journal":{"name":"Journal of Bone and Mineral Metabolism","volume":" ","pages":""},"PeriodicalIF":2.2,"publicationDate":"2026-04-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147662463","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Incident subclinical vertebral fractures and health-related quality of life: JPOS cohort study.","authors":"Mayumi Uesaka, Masami Hamada, Takahiro Tachiki, Yuho Sato, Kouji Tsuda, Asako Kudo, Kuniyasu Kamiya, Nami Imai, Akemi Nitta, Miho Tanaka, Kumiko Ohara, Naoyuki Takashima, Jun Kitagawa, Katsuyasu Kouda, Akemi Morita, Kazuhiro Uenishi, Etsuko Kajita, Koji Tamakoshi, Sadanobu Kagamimori, Junko Tamaki, Masayuki Iki","doi":"10.1007/s00774-026-01721-3","DOIUrl":"https://doi.org/10.1007/s00774-026-01721-3","url":null,"abstract":"<p><strong>Introduction: </strong>Vertebral fractures are the most common osteoporotic fractures, yet approximately two-thirds of radiographically detectable fractures remain clinically unrecognized. The longitudinal impact of such subclinical vertebral fractures on health-related quality of life (HRQOL) is not fully clarified. This study examined whether incident subclinical vertebral fractures were associated with subsequent changes in HRQOL.</p><p><strong>Materials and methods: </strong>This study was nested within the Japanese Population-based Osteoporosis (JPOS) Cohort. Community-dwelling women aged ≥ 50 years without clinical fractures were included. Incident subclinical vertebral fractures, assessed by single-energy X-ray absorptiometry-based vertebral fracture assessment with morphometry, were the primary exposure. HRQOL was evaluated using Japanese SF-36® v2. General linear models estimated associations between incident fractures and follow-up SF-36® subscale scores, adjusting for baseline HRQOL and prespecified covariates. Sensitivity analyses excluding participants with pre-baseline subclinical vertebral fractures or with anti-osteoporosis medication were performed.</p><p><strong>Results: </strong>Of 344 participants, 53 (15.4%) developed incident subclinical vertebral fractures. Baseline SF-36® standardized subscale scores did not differ between groups. At follow-up, women with incident fractures had significantly lower physical functioning and social functioning scores. After multivariable adjustment, social functioning remained significantly lower in the fracture group (false discovery rate-adjusted p = 0.028). Social functioning declined progressively with increasing fracture number and was significantly lower in lumbar fractures. Sensitivity analyses yielded consistent results with primary analyses.</p><p><strong>Conclusions: </strong>Incident subclinical vertebral fractures among community-dwelling Japanese women were independently associated with clinically meaningful declines in social functioning, suggesting the importance of early identification to prevent deterioration in HRQOL.</p>","PeriodicalId":15116,"journal":{"name":"Journal of Bone and Mineral Metabolism","volume":" ","pages":""},"PeriodicalIF":2.2,"publicationDate":"2026-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147654214","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comment on \"Assessing deep learning model performance in osteoporosis screening with lumbar spine radiographs\".","authors":"Dhananjay Kumar Mishra, Koyel Roy, Tarun Madan Kanade","doi":"10.1007/s00774-026-01725-z","DOIUrl":"10.1007/s00774-026-01725-z","url":null,"abstract":"","PeriodicalId":15116,"journal":{"name":"Journal of Bone and Mineral Metabolism","volume":" ","pages":""},"PeriodicalIF":2.2,"publicationDate":"2026-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147639069","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}