Journal of Bone and Mineral Metabolism最新文献

{"title":"Dietary mineral insufficiency and osteoporosis risk across skeletal sites in older Iranian adults: IMOS-2021.","authors":"Faezeh Sehatpour, Farima Farsi, Arash Ghazbani, Mahnaz Sanjari, Kazem Khalagi, Atefeh Amrollahi Bioky, Samaneh Akbarpour, Hamidreza Aghaei Meybodi, Nazli Namazi, Afshin Ostovar, Noushin Fahimfar, Bagher Larijani","doi":"10.1007/s00774-026-01754-8","DOIUrl":"https://doi.org/10.1007/s00774-026-01754-8","url":null,"abstract":"<p><strong>Introduction: </strong>The aim of this study was to examine Iranian adults aged 50 and above to determine the association between the prevalence of regional osteoporosis and their dietary intake of phosphorus, magnesium, potassium, and zinc.</p><p><strong>Materials and methods: </strong>We conducted a cross-sectional analysis of 1353 participants (406 with osteoporosis, 947 healthy) from the Iranian Multicenter Osteoporosis Study (IMOS-2021). A validated 168-item food frequency questionnaire was utilized to evaluate dietary intake. The lumbar spine, whole hip, and femoral neck were assessed for bone mineral density (BMD) with dual-energy x-ray absorptiometry. Multivariable logistic regression models were used to estimate odds ratios (ORs) for osteoporosis, adjusting for potential confounders.</p><p><strong>Results: </strong>Participants with osteoporosis were significantly older (63.76 vs. 59.61 years, P < 0.001), more likely to be women (67.2% vs. 50.4%, P < 0.001), and had lower intakes of all measured minerals (all P < 0.001). Correlation analyses revealed significant positive associations between all minerals and BMD at all skeletal sites (all P ≤ 0.01). In univariable models, insufficient phosphorus intake was associated with spine osteoporosis (OR = 1.56, P = 0.006) and total osteoporosis (OR = 1.49, P = 0.008), while insufficient potassium intake was linked to total osteoporosis (OR = 1.79, P = 0.031). After adjustment, only insufficient phosphorus intake remained significant for spine osteoporosis (OR = 1.71, P = 0.008).</p><p><strong>Conclusion: </strong>Our findings suggest that dietary phosphorus may be independently associated with osteoporosis risk in this population; however, prospective studies incorporating objective dietary assessment, broader lifestyle factors, and fracture-related outcomes are needed to confirm causality and address residual confounding.</p>","PeriodicalId":15116,"journal":{"name":"Journal of Bone and Mineral Metabolism","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2026-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148864940","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of dual-energy X-ray absorptiometry and lumbar radiographs using deep learning for osteoporosis diagnosis.","authors":"Deniz Apalan, Bulent Yildiz, Ozlem Polat, Irfan Atik, Ismail Salk","doi":"10.1007/s00774-026-01752-w","DOIUrl":"https://doi.org/10.1007/s00774-026-01752-w","url":null,"abstract":"<p><strong>Introduction: </strong>Osteoporosis and osteopenia, characterized by reduced bone mineral density (BMD), increase fracture risk, particularly in older adults. Early detection is critical for preventing fractures and preserving quality of life. Variability in radiographic interpretation highlights the need for automated diagnostic approaches. This study evaluates whether deep learning (DL) analysis of lumbar radiographs can serve as an alternative to dual-energy X-ray absorptiometry (DEXA) for detecting osteopenia and osteoporosis.</p><p><strong>Materials and methods: </strong>In this retrospective study, 1039 patients (aged 20-95 years, mean 64.99 ± 11.61) who underwent both DEXA and lumbar spine radiography within three months were included. BMD was classified using T-scores for adults over 50, including postmenopausal women and men, and Z-scores for younger participants. Lateral lumbar radiographs (L1-L4) were categorized as normal, osteopenic, or osteoporotic according to DEXA results. Five pretrained transfer learning models (DenseNet-169, EfficientNet-B7, Inception-ResNetV2, ResNet-152V2, Xception) were used for feature extraction, with hyperparameters optimized using the Grey Wolf Optimization (GWO) algorithm. Models were evaluated for both multiclass and binary classification tasks.</p><p><strong>Results: </strong>In multiclass classification, DenseNet169 achieved the highest test AUC of 0.81. In binary classification, Xception (AUC: 0.90) was most effective in distinguishing normal from osteopenia, while InceptionResNetV2 (accuracy: 90.08%) performed best in separating normal from osteoporosis.</p><p><strong>Conclusions: </strong>These results suggest that DL analysis of lumbar radiographs, combined with transfer learning and metaheuristic optimization, may support BMD category classification as a complementary screening tool. This approach may provide a reliable, non-invasive, and accessible alternative to DEXA for osteoporosis screening and diagnosis.</p>","PeriodicalId":15116,"journal":{"name":"Journal of Bone and Mineral Metabolism","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2026-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148850555","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The impact of metabolic syndrome on changes in trunk muscle CSA: a 10-year longitudinal study.","authors":"Yosuke Mano, Eiichiro Nakamura, Manabu Tsukamoto, Takayuki Nabeshima, Toru Nakagawa, Yoichi Murata, Masaru Takeda, Kenichiro Narusawa, Kenji Shimizu, Yoshiaki Yamanaka, Hitoshi Suzuki, Soshi Uchida, Takeshi Hayashi, Akinori Sakai","doi":"10.1007/s00774-026-01750-y","DOIUrl":"https://doi.org/10.1007/s00774-026-01750-y","url":null,"abstract":"<p><strong>Introduction: </strong>Few studies have investigated the relationship between metabolic syndrome (MetS) and muscle loss over a 10-year period in large working populations. This study aimed to investigate the influence of MetS-related and respiratory factors on changes in trunk muscles in the working population.</p><p><strong>Materials and methods: </strong>The cross-sectional areas (CSAs) of the psoas major (PM) and erector spinae (ES) were measured using abdominal low-dose CT imaging at baseline and at 10 years. Predictors of CSA loss were analyzed using multiple linear regression analysis.</p><p><strong>Results: </strong>A total of 1504 males were included. The change in the CSA of the PM at 10 years decreased significantly with increasing age, BMI, abdominal circumference, visceral fat area (VFA), systolic blood pressure (sBP), and HbA1c. The change in the CSA of the ES at 10 years decreased significantly with increasing age, weight, BMI, abdominal circumference, VFA, sBP, HbA1c, and LDL level. Multiple linear regression analysis revealed that VFA and HbA1c were independently associated with PM loss, while a lower percentage vital capacity (%VC) was associated with ES loss. The ratio of forced expiratory volume in one second to forced vital capacity (FEV1.0%) at baseline was identified as a significant predictor of PM loss for individuals with MetS.</p><p><strong>Conclusion: </strong>Among MetS-related factors, VFA and HbA1c were associated with trunk muscle CSA loss over 10 years in the working population. Furthermore, in individuals with MetS, lower FEV1.0% was associated with PM loss.</p>","PeriodicalId":15116,"journal":{"name":"Journal of Bone and Mineral Metabolism","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2026-08-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148793452","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring the causal relationship and pathogenesis of intracranial aneurysms with osteoporosis based on Mendelian randomization and bioinformatics study.","authors":"Feng Chen, Pingyou He, Wei Xu, Danfeng Yu, Chao Luo","doi":"10.1007/s00774-026-01749-5","DOIUrl":"https://doi.org/10.1007/s00774-026-01749-5","url":null,"abstract":"<p><strong>Introduction: </strong>Intracranial aneurysms (IA) and osteoporosis (OP) are both common conditions among the elderly population. Observational studies suggest a potential association between OP and IA. However, the causal relationships and biological mechanisms underlying these associations remain unclear.</p><p><strong>Materials and methods: </strong>We performed bidirectional two-sample Mendelian randomization (TSMR) analysis using summary statistics from European genome-wide association studies. The inverse variance weighted (IVW) method served as the primary approach for causal inference. Furthermore, sensitivity analyses were conducted to evaluate the potential level of heterogeneity and horizontal pleiotropy, thereby demonstrating the robustness of the findings. Subsequent bioinformatics analysis employed machine learning algorithms to identify potential OP-related diagnostic biomarkers in IA, with diagnostic performance assessed using receiver operating characteristic curves. Furthermore, immune infiltration analysis was performed to preliminarily characterize the immune microenvironment features in IA patients.</p><p><strong>Results: </strong>IVW results suggested a potential association between low bone density and an increased risk of IA, although this finding did not remain significant after correction for multiple testing. Reverse Mendelian randomization (MR) analysis revealed that the genetic susceptibility to IA did not have a significant impact on the relative risk of bone density. Furthermore, our study identified 5 potential OP-related biomarkers in IA, which showed valuable diagnostic performance. Immune cell infiltration analysis suggested that the formation of IA may be related to immune responses induced by CD8 T cells, macrophages, and mast cells.</p><p><strong>Conclusion: </strong>These findings provide valuable insights into the relationship between OP and IA, offering new perspectives for the diagnosis and treatment of IA.</p>","PeriodicalId":15116,"journal":{"name":"Journal of Bone and Mineral Metabolism","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2026-08-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148793504","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A DXA-based profile of body composition in celiac patients: a cross-sectional retrospective study.","authors":"Mirjana Di Paolo, Mirena Buttazzoni, Marcelina Carretero, María Laura Gonzalez, Mariano Martín Marcolongo, María Dolores Matoso","doi":"10.1007/s00774-026-01742-y","DOIUrl":"https://doi.org/10.1007/s00774-026-01742-y","url":null,"abstract":"<p><strong>Introduction: </strong>Celiac disease (CD) is frequently associated with bone and mineral metabolism alterations. As the clinical phenotype shifts from malabsorptive to normal-weight or obese, precise evaluation of body composition is essential to assess metabolic and sarcopenia risks. This study utilized Dual-Energy X-ray Absorptiometry (DXA) to characterize body composition and Bone Mineral Density (BMD) in a contemporary adult CD cohort.</p><p><strong>Materials and methods: </strong>We conducted a single-center, retrospective observational study of 77 CD patients (73% female) under 52 years of age; menopausal women were excluded. DXA was used to measure Appendicular Lean Mass Index (ALMI) Z-score, Bone Mineral Content (BMC) Z-score, and Total BMD Z-score.</p><p><strong>Results: </strong>Soft tissue parameters, including ALMI and fat mass Z-scores, clustered around zero for both sexes, indicating a composition profile comparable to the NHANES reference population. Conversely, bone health was consistently compromised, especially in women. Female patients exhibited negative Total BMD Z-scores across all age groups, with the lowest mean in the 40-44 age cohort (- 1.0 ± 1.0). BMC Z-scores were also predominantly negative (e.g., - 1.1 ± 1.5 in the 40-44 group). Male patients showed heterogeneous BMD Z-scores, ranging from - 1.04 ± 1.0 (25-29 years) to positive values in older subgroups.</p><p><strong>Conclusion: </strong>In this cohort, the modern CD phenotype presents a preserved soft tissue composition. However, low BMD remains a persistent finding, particularly in premenopausal women. These results underscore the necessity of systematic DXA screening in adult CD patients, regardless of their body mass index or clinical presentation.</p>","PeriodicalId":15116,"journal":{"name":"Journal of Bone and Mineral Metabolism","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2026-08-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148793516","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Gut microbiota transmits osteoimmune dysregulation and exacerbates trabecular bone loss in tristetraprolin-deficient mice.","authors":"Kyu Hwan Kwack, Jiho Sohn, Lixia Zhang, Lu Li, Reegan Mullaney, Yukitomo Arao, Perry J Blackshear, Keith L Kirkwood","doi":"10.1007/s00774-026-01753-9","DOIUrl":"https://doi.org/10.1007/s00774-026-01753-9","url":null,"abstract":"<p><strong>Introduction: </strong>Tristetraprolin (TTP) is an RNA-binding protein essential for controlling cytokine production, and its deficiency leads to profound skeletal deterioration. Although TTP deficiency is associated with systemic inflammation and microbial dysbiosis, the contribution of the gut microbiota to bone pathology remains poorly defined.</p><p><strong>Materials and methods: </strong>We investigated whether the microbiome causally modulates osteoimmune mechanisms and bone microarchitecture in TTP-deficient mice. To isolate the effects of the microbiome, we utilized specific pathogen-free (SPF) and germ-free (GF) co-housing mouse models.</p><p><strong>Results: </strong>Microbial transfer bidirectionally regulated systemic inflammation and the expansion of monocytic myeloid-derived suppressor cells (M-MDSCs), a population with potent osteoclastogenic capacity. Importantly, microbiota transfer was sufficient to induce osteoclast activation and a selective deterioration of trabecular bone microarchitecture in otherwise healthy mice, without affecting overall bone mass. Crucially, the transmission of these osteoimmune and skeletal phenotypes was microbiota-dependent; while a baseline genetic bone deficit persisted in GF TTP-deficient mice, the co-housing-induced M-MDSC expansion and trabecular bone alterations were not observed under GF conditions.</p><p><strong>Conclusion: </strong>Our findings identify a microbiota-dependent osteoimmune axis that amplifies inflammatory bone loss in TTP deficiency. This work establishes the gut microbiome as a mechanistic modifier of bone quality in genetically driven inflammatory disease and highlights microbial targeting as a potential therapeutic strategy for inflammatory bone loss.</p>","PeriodicalId":15116,"journal":{"name":"Journal of Bone and Mineral Metabolism","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2026-08-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148793482","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessment of bone involvement by DXA and HR-pQCT in patients with X-linked hypophosphatemia.","authors":"Iara Marcelino Sant Ana, Maria Caroline Alves Coelho, Joyce Cantoni, Leandro Kasuki, Maria Lucia Fleiuss Farias, Miguel Madeira","doi":"10.1007/s00774-026-01748-6","DOIUrl":"https://doi.org/10.1007/s00774-026-01748-6","url":null,"abstract":"<p><strong>Introduction: </strong>X-linked hypophosphatemic rickets (XLH) is a rare disease and its natural history affects the quality of life of patients, as it leads to bone deformities and architectural and qualitative changes in the bone.</p><p><strong>Materials and methods: </strong>Sixteen XLH patients were selected from referral hospitals in Rio de Janeiro (12 women and four men) and compared to 16 healthy age- and sex-matched control individuals. All XLH were receiving calcitriol and oral phosphate supplements. Bone assessment was performed by high-resolution peripheral quantitative computed tomography (HR-pQCT) and dual-energy X-ray absorptiometry (DXA).</p><p><strong>Results: </strong>XLH patients showed higher lumbar spine BMD Z-score, but lower 33% distal radius BMD and Z-score values as compared to control group. Low BMD for age (Z-score ≤ -2.0 SD) was only detected in the XLH group: specifically in 3 of the 5 postmenopausal women, 3 of the 7 premenopausal women, and 2 of the 4 men. HR-pQCT evaluation showed lower total vBMD at both peripheral sites and impaired trabecular parameters, particularly at the distal tibia, after correction for multiple comparisons.</p><p><strong>Conclusion: </strong>Our study sheds light on the involvement of both trabecular and cortical compartments in the XLH group, despite conventional treatment. We also emphasize the limitation of DXA in assessing central sites in the XLH group. The 33% radius may represent a useful complementary skeletal site for DXA assessment, particularly when HR-pQCT is not available.</p>","PeriodicalId":15116,"journal":{"name":"Journal of Bone and Mineral Metabolism","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2026-08-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148706637","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluating Haversian canal-to-osteon ratios for reconstructing bone remodelling activity: balancing precision and efficiency in data collection.","authors":"Karen M Cooke, Isabella Pearce, R Claire Aland, Julien Louys, Patrick Mahoney, Justyna J Miszkiewicz","doi":"10.1007/s00774-026-01747-7","DOIUrl":"https://doi.org/10.1007/s00774-026-01747-7","url":null,"abstract":"<p><strong>Introduction: </strong>In cortical bone histology, the ratio of Haversian canal and secondary osteon areas reflects bone resorption and formation during metabolic events executed by Basic Multicellular Units (BMUs). Area data can be pooled where they are collected independently, and the ratio calculated from the mean of each measure. They can also be paired, where they are measured from the same secondary osteon at once and the mean of individual ratios is calculated. We evaluate the impact of pooling and pairing on the resulting ratio values and their interpretation of bone remodelling.</p><p><strong>Materials and methods: </strong>Using both approaches, we calculated the area ratio of 551 Haversian canals and secondary osteons from measurements of existing midshaft femur histology slides. The sample represents n = 38 young and middle-aged females of different social backgrounds from a historical osteological collection. Univariate and bivariate statistics were used to compare and evaluate paired and pooled values and their differences.</p><p><strong>Results: </strong>The pooled method usually returned a lower canal-to-osteon value than paired data across the whole sample, ages, and social groups. These methods differed in the ratios they produced, independently of the number of measurements per sample.</p><p><strong>In conclusion: </strong>The pooling technique indicated the presence of thicker lamellar bone within secondary osteons, suggesting greater quantities of bone formed during BMU activity, than the paired technique results, which suggested less bone formed per BMU. While pooling offers efficiency in data collection and analysis, we show that paired data yield more biologically precise and analytically flexible results at an individual BMU level.</p>","PeriodicalId":15116,"journal":{"name":"Journal of Bone and Mineral Metabolism","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2026-08-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148706674","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Response to: \"Comment on \"Trends in the incidence of secondary hip fractures and osteoporosis treatment in Japan (FY2012-FY2023)\"\".","authors":"Shinichi Nakatoh","doi":"10.1007/s00774-026-01746-8","DOIUrl":"https://doi.org/10.1007/s00774-026-01746-8","url":null,"abstract":"","PeriodicalId":15116,"journal":{"name":"Journal of Bone and Mineral Metabolism","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2026-08-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148684601","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Response to: \"Comment on 'Identification of potential diagnostic and therapeutic apoptosis-related causal targets for osteoporosis: an integrated multi-omics analysis'\".","authors":"Yixi Wang, Lintao Xia, Yang Xiao, Mingxing Wu, Rui Zhang, Paerhati Rexiti, Hui Zhang","doi":"10.1007/s00774-026-01744-w","DOIUrl":"https://doi.org/10.1007/s00774-026-01744-w","url":null,"abstract":"","PeriodicalId":15116,"journal":{"name":"Journal of Bone and Mineral Metabolism","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2026-08-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148684587","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}