Journal of Bone and Mineral Metabolism最新文献

Response to "Unhealthy lifestyles accelerated aging and consequential musculoskeletal morbidity: a critical appraisal". 对“不健康的生活方式加速衰老和随之而来的肌肉骨骼疾病：一项批判性评估”的回应。

IF 2.2 3区医学

Journal of Bone and Mineral Metabolism Pub Date : 2025-10-07 DOI: 10.1007/s00774-025-01649-0

Hao-Long Zhou, Jiao-Jun Liang, Jonathan K L Mak, Zhang-Bo Cui, Dan-Yang Ling, Sara Hägg, Qi Wang

引用次数: 0

The role of Tmem119 in the estrogen action on bone in mice. Tmem119在雌激素对小鼠骨作用中的作用。

IF 2.2 3区医学

Journal of Bone and Mineral Metabolism Pub Date : 2025-10-04 DOI: 10.1007/s00774-025-01644-5

Akihito Nishikawa, Naoyuki Kawao, Yuya Mizukami, Koji Goto, Hiroshi Kaji

{"title":"The role of Tmem119 in the estrogen action on bone in mice.","authors":"Akihito Nishikawa, Naoyuki Kawao, Yuya Mizukami, Koji Goto, Hiroshi Kaji","doi":"10.1007/s00774-025-01644-5","DOIUrl":"https://doi.org/10.1007/s00774-025-01644-5","url":null,"abstract":"Introduction: Postmenopausal osteoporosis is a critical task in the clinical management of older individuals. Numerous studies have proposed various pathophysiological mechanisms for postmenopausal osteoporosis. Tmem119 is a crucial factor for osteoblastic bone formation, and we previously clarified its contribution to the bone anabolic effects of various osteotropic factors. However, the roles of Tmem119 in postmenopausal osteoporosis and the effects of estrogen on bone remain unknown. Therefore, we herein investigated the roles of Tmem119 in bilateral ovariectomized mice with or without Tmem119 deficiency and/or the administration of estrogen.Materials and methods: Wild-type and Tmem119-deficient mice underwent bilateral ovariectomy (OVX) and subcutaneous injections of 17β-estradiol for 6 weeks. We measured bone parameters in the femurs of mice using micro-computed tomography.Results: OVX reduced the uterine weight and trabecular bone parameters, which were increased by estrogen administration. Tmem119 deficiency significantly blunted estrogen-induced increases in uterine weight, trabecular bone volume, and trabecular thickness in OVX mice. Tmem119 deficiency also significantly blunted estrogen-induced increases in alkaline phosphatase activity in mouse osteoblasts.Conclusion: Our data indicated that Tmem119 is partly involved in the effects of estrogen on trabecular osteopenia induced by estrogen deficiency presumably by affecting osteoblasts in female mice.","PeriodicalId":15116,"journal":{"name":"Journal of Bone and Mineral Metabolism","volume":" ","pages":""},"PeriodicalIF":2.2,"publicationDate":"2025-10-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145225105","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

One-year bone mineral density gains with anti-osteoporotic medications and clinical factors associated with non-BMD gainers. 使用抗骨质疏松药物和与非骨密度增加相关的临床因素，一年骨密度增加。

IF 2.2 3区医学

Journal of Bone and Mineral Metabolism Pub Date : 2025-10-03 DOI: 10.1007/s00774-025-01641-8

Seol A Jang, Seok-Jae Heo, Su Jin Kwon, Chul Sik Kim, Seok Won Park, Kyoung Min Kim

{"title":"One-year bone mineral density gains with anti-osteoporotic medications and clinical factors associated with non-BMD gainers.","authors":"Seol A Jang, Seok-Jae Heo, Su Jin Kwon, Chul Sik Kim, Seok Won Park, Kyoung Min Kim","doi":"10.1007/s00774-025-01641-8","DOIUrl":"https://doi.org/10.1007/s00774-025-01641-8","url":null,"abstract":"Introduction: Despite the increasing number of anti-osteoporotic medications for improving bone mineral density (BMD) and reducing fracture risk, some patients show unsatisfactory responses.Materials and methods: We retrospectively analyzed 2134 patients who received anti-osteoporotic medications between March 2020 and October 2024. BMD percentage changes at the lumbar spine, femoral neck, and total hip were assessed after 1 year. Patients were categorized as \"non-BMD gainers\" (<3% increase at all sites) or \"BMD gainers\" (≥3% increase at any site). Multivariable logistic regression was used to evaluate associations with non-BMD gainer status, including age, body mass index, baseline T-score, and medication class.Results: 578 patients (27.1%) were classified as non-BMD gainers. The observed rates of non-BMD gainer varied across medication classes in this real-world cohort, with selective estrogen receptor modulators (SERMs) showing the highest non-BMD gain rate (46.0%), followed by bisphosphonates (32.2%), teriparatide (35.1%), denosumab (19.5%), and romosozumab (5.6%). Non-BMD gainers had high baseline BMD and low bone turnover markers, and were more likely to have a history of osteoporosis treatment. In multivariable logistic regression analysis, older age (≥75 years), SERM use, and high baseline BMD T-scores were independently associated with increased risk of non-BMD gainer status. Conversely, low T-scores (≤-3.0) were associated with a significantly reduced likelihood of being a non-BMD gainer.Conclusion: Approximately 25% of patients did not achieve BMD gain after 1 year of treatment. Older age, higher baseline BMD T-scores, and SERM use were associated with an increased probability of non-BMD gainer status in this observational study.","PeriodicalId":15116,"journal":{"name":"Journal of Bone and Mineral Metabolism","volume":" ","pages":""},"PeriodicalIF":2.2,"publicationDate":"2025-10-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145225149","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Platelet-like cells differentiated from adipose-derived mesenchymal stem cells inhibit acute inflammation of tendinopathy in rats. 脂肪来源的间充质干细胞分化的血小板样细胞抑制大鼠肌腱病的急性炎症。

IF 2.2 3区医学

Journal of Bone and Mineral Metabolism Pub Date : 2025-10-03 DOI: 10.1007/s00774-025-01647-2

Akiko Torii, Yuichi Yamada, Yukako Ono-Uruga, Yuiko Sato, Yosuke Kaneko, Satoshi Nakamura, Takuji Iwamoto, Yumiko Matsubara, Morio Matsumoto, Masaya Nakamura, Kazuki Sato, Takeshi Miyamoto

{"title":"Platelet-like cells differentiated from adipose-derived mesenchymal stem cells inhibit acute inflammation of tendinopathy in rats.","authors":"Akiko Torii, Yuichi Yamada, Yukako Ono-Uruga, Yuiko Sato, Yosuke Kaneko, Satoshi Nakamura, Takuji Iwamoto, Yumiko Matsubara, Morio Matsumoto, Masaya Nakamura, Kazuki Sato, Takeshi Miyamoto","doi":"10.1007/s00774-025-01647-2","DOIUrl":"https://doi.org/10.1007/s00774-025-01647-2","url":null,"abstract":"Introduction: Tendinopathy, a disease that causes inflammation and pain and limits patients' activities of daily living, is considered particularly important to treat during the acute inflammatory phase to prevent the transition to chronic degeneration. Recently, platelet-rich plasma (PRP) has been used to treat tendinopathy; however, it is not clear whether platelets themselves, which are the active component of PRP, could be effective in treating tendinopathy.Materials and methods: We made rat Achilles tendinopathy models by incision of the calcaneal attachment and administrated platelet-like cells derived from adipose-derived mesenchymal stem cells (ASCL-PLCs) to the injury site and investigated the anti-inflammatory effect.Results: ASCL-PLCs significantly inhibits the inflammatory cytokine expression and inflammatory cell infiltration in acute tendonitis in a rat Achilles tendon injury model in vivo. Interestingly, we observed no xeno-reaction when human-derived ASCL-PLCs were administered to wild-type rats in vivo. Moreover, IL-6 expression and phosphorylation seen in NIH3T3 fibroblasts treated with IL-6 plus soluble IL-6 receptor were both significantly suppressed by ASCL-PLCs in vitro.Conclusion: ASCL-PLC has advantages over existing PRP therapies, including the ability to be cryopreserved after quality checks, and homogeneous populations of ASCL-PLCs can be prepared in large quantity. We conclude that in the future ASCL-PLCs may serve as an allogeneic transplant effective to treat tendinopathy.","PeriodicalId":15116,"journal":{"name":"Journal of Bone and Mineral Metabolism","volume":" ","pages":""},"PeriodicalIF":2.2,"publicationDate":"2025-10-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145212664","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Three-year trends in early hip fracture surgery surrounding a national reimbursement policy in Japan. 围绕日本国家报销政策的早期髋部骨折手术的三年趋势。

IF 2.2 3区医学

Journal of Bone and Mineral Metabolism Pub Date : 2025-10-01 DOI: 10.1007/s00774-025-01650-7

Yukihiro Kokubu, Aya Obi, Yuka Kimura, Aya Hattori, Hisanori Nemoto, Yujiro Matsuda, Yuho Oki, Ryo Amamiya, Keita Ogine, Masaru Misawa, Tomoko Shimaoka, Keisuke Hirose, Yoshiaki Ando, Toshinori Kurashige, Kiyoma Marusugi, Shuichi Kaneyama, Hiroshi Kawaguchi

{"title":"Three-year trends in early hip fracture surgery surrounding a national reimbursement policy in Japan.","authors":"Yukihiro Kokubu, Aya Obi, Yuka Kimura, Aya Hattori, Hisanori Nemoto, Yujiro Matsuda, Yuho Oki, Ryo Amamiya, Keita Ogine, Masaru Misawa, Tomoko Shimaoka, Keisuke Hirose, Yoshiaki Ando, Toshinori Kurashige, Kiyoma Marusugi, Shuichi Kaneyama, Hiroshi Kawaguchi","doi":"10.1007/s00774-025-01650-7","DOIUrl":"https://doi.org/10.1007/s00774-025-01650-7","url":null,"abstract":"Introduction: Timely surgical intervention for hip fractures is essential for improving outcomes in older adults. Japan's Ministry of Health, Labour and Welfare (MHLW) recently introduced a reimbursement policy to incentivize hip fracture surgery within 48 h. However, the impact and sustainability of this policy remain unclear.Materials and methods: This retrospective cohort study included 498 patients aged ≥ 75 years with hip fractures at a single Japanese hospital from 2022 (pre-policy) to 2024 (post-policy year 2). We performed univariate and multivariate logistic regression analyses of the rate of early surgery (≤ 48 h) to identify predictors of surgical delay.Results: The early surgery rate rose from 42.4% in 2022 to 52.7% in 2023 but declined to 45.1% in 2024. The reimbursement policy was associated with reduced surgical delay in its first year (2023; OR = 0.58, p = 0.024), but this effect was not sustained. Key structural and clinical predictors of delay included nursing home residence, refusal at other hospitals, weekend admission, and multi-specialty consultation. The frequency of off-hours surgery decreased in 2024, possibly due to the 'Workstyle Reform for Physicians' policy. Interaction analysis showed a suggestive inverse effect of off-hours surgery on delay.Conclusion: Japan's reimbursement policy was initially effective, but its impact was transient and ultimately reversed by the competing national workstyle reform policy. Our findings underscore that to achieve sustained improvements in timely surgical care, future strategies must not only ensure coordinated policy design but also address persistent structural barriers, including weekend service gaps and fragmented regional coordination.","PeriodicalId":15116,"journal":{"name":"Journal of Bone and Mineral Metabolism","volume":" ","pages":""},"PeriodicalIF":2.2,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145199480","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Unhealthy lifestyles accelerated aging and consequential musculoskeletal morbidity: a critical appraisal. 不健康的生活方式加速衰老和相应的肌肉骨骼疾病：一个关键的评估。

IF 2.2 3区医学

Journal of Bone and Mineral Metabolism Pub Date : 2025-10-01 DOI: 10.1007/s00774-025-01646-3

Zain Ul Abedeen, Zia Ullah, Muhammad Zaib, Ayesha Saleem, Fazal Qader

引用次数: 0

Quercetin and postmenopausal bone health: beyond biomarker elevation to balance-focused endpoints. 槲皮素与绝经后骨骼健康：超越生物标志物升高到以平衡为中心的终点。

IF 2.2 3区医学

Journal of Bone and Mineral Metabolism Pub Date : 2025-10-01 DOI: 10.1007/s00774-025-01648-1

XiRui Yang, KaiFeng Qin

引用次数: 0

Association between serum zinc concentration and fracture risk in postmenopausal women: a 9-year cohort study. 绝经后妇女血清锌浓度与骨折风险的关系：一项为期9年的队列研究

IF 2.2 3区医学

Journal of Bone and Mineral Metabolism Pub Date : 2025-10-01 DOI: 10.1007/s00774-025-01645-4

Zahra Bahadoran, Farzad Hadaegh, Fereidoun Azizi, Asghar Ghasemi

{"title":"Association between serum zinc concentration and fracture risk in postmenopausal women: a 9-year cohort study.","authors":"Zahra Bahadoran, Farzad Hadaegh, Fereidoun Azizi, Asghar Ghasemi","doi":"10.1007/s00774-025-01645-4","DOIUrl":"https://doi.org/10.1007/s00774-025-01645-4","url":null,"abstract":"Introduction: The association between serum zinc (SZn) concentration and fracture risk in postmenopausal women was investigated.Materials and methods: Women (n = 851) with a history of natural, premature, or surgical menopause who had completed data, including SZn concentrations at baseline (2009-2011), were included and followed through March 2018 for the incidence of any fracture requiring inpatient care. Potential non-linear and dose-response associations between SZn and fracture risk were assessed using a restricted cubic spline model (RCS) in Cox regression with the likelihood ratio test (LRT). Multivariable Cox proportional hazard models were used to estimate adjusted hazard ratios (HRs) and 95% confidence intervals (CIs) of fractures across the categories of SZn [< 86, 86-135 (as reference), and ≥ 135 μg/dL].Results: During a median follow-up period of 8.8 years (interquartile range: 8.1-9.2 years), 4.3% of postmenopausal women (with a mean age of 61.4 ± 8.6 years) experienced a new incident fracture. The mean of baseline SZn concentration was 113 ± 39.3 μg/dL. The LRT indicated no significant non-linear association (P = 0.176) and no evidence of a dose-response relationship (P = 0.448) between SZn and fracture risk. Using the categorical approach, the multivariable-adjusted Cox model showed that postmenopausal women with SZn concentrations below 86 μg/dL had a significantly increased risk of fracture compared to those within the reference range (86-135 μg/dL), with an HR of 2.29 (95% CI = 1.02-5.16, P = 0.044). SZn concentrations exceeding the reference range (≥ 135 μg/dL) were not associated with risk of fractures (HR = 1.47, 95% CI = 0.61-3.58).Conclusions: Suboptimal SZn levels, indicative of inadequate zinc status, may contribute to an increased risk of bone fractures in postmenopausal women.","PeriodicalId":15116,"journal":{"name":"Journal of Bone and Mineral Metabolism","volume":" ","pages":""},"PeriodicalIF":2.2,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145199493","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Comment on "Independent risk factors and survival prediction in hip refractures patients: insights from a 10-year cohort". 对“髋关节复发患者的独立危险因素和生存预测：来自10年队列的见解”的评论。

IF 2.2 3区医学

Journal of Bone and Mineral Metabolism Pub Date : 2025-10-01 DOI: 10.1007/s00774-025-01634-7

Caroline Francis, Gujar Anantkumar Jotiram, Inamul Hasan Madar

引用次数: 0

Author's response to letter to the editor: Re: Probability of achieving treatments goals with twice-weekly teriparatide followed by bisphosphonate in Japanese postmenopausal osteoporosis. 作者回复编辑：回复：在日本绝经后骨质疏松症患者中，每周两次特立帕肽加双膦酸盐治疗达到治疗目标的可能性。

IF 2.2 3区医学

Journal of Bone and Mineral Metabolism Pub Date : 2025-09-23 DOI: 10.1007/s00774-025-01636-5

Junichi Takada, Kousuke Iba, Tsuneo Takebayashi, Megumi Hanaka, Tomohiro Akatsuka, Atsushi Teramoto

引用次数: 0