Journal of Bone and Mineral Metabolism最新文献

{"title":"Editorial comment.","authors":"Toshio Matsumoto, Toshiyuki Yoneda","doi":"10.1007/s00774-026-01772-6","DOIUrl":"https://doi.org/10.1007/s00774-026-01772-6","url":null,"abstract":"","PeriodicalId":15116,"journal":{"name":"Journal of Bone and Mineral Metabolism","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2026-10-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149182026","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Propionibacterium cheese and bone turnover in active young adults: a randomized-controlled trial.","authors":"Helge Einar Lundberg, Stig Larsen, Therese Fostervold Mathisen, Tove Tveitan Borgen, Jorunn Sundgot-Borgen","doi":"10.1007/s00774-026-01761-9","DOIUrl":"https://doi.org/10.1007/s00774-026-01761-9","url":null,"abstract":"<p><strong>Introduction: </strong>Young physically active individuals exposed to prolonged physiological stress and low energy availability are prone to reduced gonadal steroid protection and increased bone turnover. Nutritional strategies that favor positive bone remodeling balance are of clinical interest. Jarlsberg cheese contains Propionibacterium freudenreichii (PF), which produces vitamin K₂ and 1,4-dihydroxy-2-naphthoic acid (DHNA), compounds with potential favorable effects on bone health.</p><p><strong>Materials and methods: </strong>In this 24-week sex-stratified randomized-controlled trial, 60 young physically active adults engaged in endurance training were allocated to daily intake of either Jarlsberg cheese or a nutritionally comparable control cheese without PF. The primary outcome was change in serum total osteocalcin (tOC). Secondary outcomes were changes in carboxylated osteocalcin (cOC), procollagen type 1 N-terminal propeptide (P1NP), cross-linked C-terminal telopeptide of type I collagen (CTX), P1NP/CTX ratio, lumbar spine bone mineral density (BMD), and trabecular bone score (TBS).</p><p><strong>Results: </strong>After 24 weeks, serum tOC was significantly higher in the Jarlsberg group than in controls (38.0 vs. 26.8 ng/mL, p < 0.01). cOC and P1NP/CTX ratio increased in favor of the Jarlsberg group (p = 0.03). Lumbar spine BMD increased in the Jarlsberg group (mean change 0.012 g/cm², p = 0.03), with a greater increase than in controls (p = 0.05), and TBS showed a positive trend in the Jarlsberg group.</p><p><strong>Conclusion: </strong>Daily intake of cheese-containing PF was associated with favorable changes in bone turnover markers and increase in lumbar spine BMD. These findings suggest that PF-fermented cheese may support bone metabolism in young individuals exposed to reduced hormonal protection and high bone turnover.</p><p><strong>Protocol number: </strong>XCS-Jarlsberg/IIA.</p><p><strong>Clinicaltrials: </strong>GOV: NCT06688032.</p>","PeriodicalId":15116,"journal":{"name":"Journal of Bone and Mineral Metabolism","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2026-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149148007","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Acute-phase reaction and fracture outcomes from zoledronic acid: a systematic review and meta-analysis.","authors":"Masaki Takigawa, Kazumasa Kotake, Takahiro Tsuge, Akihiro Saitsu, Yuichi Isaji, Shunsuke Kondo, Tomoki Maruyama, Norio Yamamoto","doi":"10.1007/s00774-026-01751-x","DOIUrl":"https://doi.org/10.1007/s00774-026-01751-x","url":null,"abstract":"<p><strong>Introduction: </strong>Zoledronic acid (ZOL), an intravenous bisphosphonate used to treat osteoporosis, is frequently associated with the development of an acute-phase reaction (APR). Although some studies have reported that the APR may correlate with fracture outcomes, the evidence remains inconsistent. This systematic review and meta-analysis aimed to investigate the association between the occurrence of an APR and fracture outcomes following ZOL therapy.</p><p><strong>Materials and methods: </strong>We searched MEDLINE, EMBASE, CENTRAL, International Clinical Trials Registry Platform, and ClinicalTrials.gov through April 2025 for observational studies and secondary analyses of randomized controlled trials in adults with osteoporosis. The primary outcome was the incidence of osteoporotic fractures. Secondary outcomes were mortality and changes in bone mineral density (BMD) and bone turnover markers (BTMs). The meta-analyses were performed using random-effects models and the certainty of evidence was assessed using the GRADE approach.</p><p><strong>Results: </strong>Seven studies were included in the final analysis. No significant association was observed between APR and fracture risk (all fractures: odds ratio (OR) 0.79, 95% confidence interval (CI) 0.19-3.26; vertebral fractures: OR 0.76, 95%CI 0.17-3.32). Similarly, no significant association was found between developing an APR and all-cause mortality, or changes in BMD, or BTMs. The certainty of the evidence ranged from very low to moderate.</p><p><strong>Conclusion: </strong>Current evidence is insufficient to establish a clear association between ZOL-induced APR and fracture risk, mortality, or BMD outcomes among patients with osteoporosis. To accurately capture potential associations, future large-scale prospective studies should enroll high-risk patients, including bisphosphonate-naïve individuals, and evaluate baseline BTMs and short-term mortality.</p>","PeriodicalId":15116,"journal":{"name":"Journal of Bone and Mineral Metabolism","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2026-10-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149110196","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Factors associated with improved quality of life in severe osteoporosis: a post hoc analysis of JOINT-05.","authors":"Hiroyuki Inose, Satoshi Mori, Hiroshi Hagino, Satoshi Soen","doi":"10.1007/s00774-026-01764-6","DOIUrl":"https://doi.org/10.1007/s00774-026-01764-6","url":null,"abstract":"<p><strong>Introduction: </strong>The goal of modern osteoporosis management is to prevent fractures and preserve patient quality of life (QOL). However, factors associated with changes in QOL during treatment, particularly for patients with severe osteoporosis, are not well understood. This study aimed to identify clinical and biochemical factors associated with the magnitude of QOL improvement in this high-risk population.</p><p><strong>Materials and methods: </strong>This was a post hoc analysis of data from the Japan Osteoporosis Intervention Trial-05 (JOINT-05). The analysis included 612 women with severe osteoporosis, with a mean age of 81.3 years. The primary endpoint was the change in the EuroQol-5 dimensions (EQ-5D) utility score over 72 weeks. Potential baseline factors included patient demographics, oral health status (number of remaining teeth), low back pain intensity (visual analog scale, VAS), and biochemical markers. Factors associated with QOL change were evaluated using exploratory regression analyses and a clinically informed multivariable linear regression model.</p><p><strong>Results: </strong>Following the treatment period, mean QOL scores improved significantly. In the clinically informed multivariable model, baseline EQ-5D, number of remaining teeth, serum tartrate-resistant acid phosphatase 5b levels, and corrected urinary pentosidine levels were independently associated with the change in EQ-5D from baseline to 72 weeks.</p><p><strong>Conclusion: </strong>This study identified several clinical and biochemical factors associated with QOL improvement in patients undergoing treatment for severe osteoporosis. These findings suggest that baseline QOL, oral health status, and biochemical markers of bone turnover and bone quality may be associated with QOL improvement during osteoporosis treatment. Further studies are needed to validate these exploratory findings.</p>","PeriodicalId":15116,"journal":{"name":"Journal of Bone and Mineral Metabolism","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2026-10-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149110199","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction: miR-195 contributes to human osteoarthritis via targeting PTHrP.","authors":"Xiaoming Cao, Zhiqing Duan, Zheyi Yan, Yongping Li, Lu Li, Jian Sun, Pengfei Han, Pengcui Li, Lei Wei, Xiaochun Wei","doi":"10.1007/s00774-026-01759-3","DOIUrl":"https://doi.org/10.1007/s00774-026-01759-3","url":null,"abstract":"","PeriodicalId":15116,"journal":{"name":"Journal of Bone and Mineral Metabolism","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2026-10-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149110147","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reply to: Comment on \"Eldecalcitol and calcium supplementation in chinese women with postmenopausal osteoporosis: a prospective observational cohort study\".","authors":"Weibo Xia, Yasuhiro Takeuchi","doi":"10.1007/s00774-026-01770-8","DOIUrl":"https://doi.org/10.1007/s00774-026-01770-8","url":null,"abstract":"","PeriodicalId":15116,"journal":{"name":"Journal of Bone and Mineral Metabolism","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2026-10-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149110171","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between RANK gene polymorphism and early femoral neck bone loss in kidney transplant recipients.","authors":"Satoshi Kitamura, Yoji Hyodo, Yuki Tashiro, Takahito Endo, Naoki Yokoyama, Takuto Hara, Koji Chiba, Hideaki Miyake","doi":"10.1007/s00774-026-01765-5","DOIUrl":"https://doi.org/10.1007/s00774-026-01765-5","url":null,"abstract":"<p><strong>Introduction: </strong>Rapid bone mineral density (BMD) loss and fracture risk are major complications of kidney transplantation (KTx), partly attributed to glucocorticoid-impaired bone remodeling. We investigated associations between early postoperative femoral neck BMD (BMD-FN) decline and single nucleotide polymorphisms (SNPs) in genes related to glucocorticoid sensitivity and bone metabolism.</p><p><strong>Materials and methods: </strong>Sixty-nine adult patients who underwent living-donor KTx in 2015-2024 were investigated. The primary endpoint was annualized BMD-FN change (%) between preoperative and 12 ± 6 months postoperative DXA. Patients with significant prior glucocorticoid exposure, postoperative pulse therapy, or anti-osteoporotic treatment were excluded. Four SNPs (NR3C1 [rs41423247], TNFRSF11A [rs1805034, rs884205], and LRP5 [rs3736228]) were genotyped and analyzed using multiple linear regression adjusted for age and sex.</p><p><strong>Results: </strong>The median annualized BMD-FN change was - 3.4% (IQR - 6.6 to - 0.7). Among the four SNPs, only TNFRSF11A rs884205 was significantly associated with greater BMD loss; A risk allele carriers showed greater decline than the CC genotype (β = - 2.75; 95% CI, - 4.82 to - 0.68; P = 0.010). No significant associations were observed for NR3C1 (rs41423247), TNFRSF11A (rs1805034), and LRP5 (rs3736228). However, after adjustment for baseline BMD-FN, which was higher in risk-allele carriers, the rs884205 association was attenuated and no longer significant (β = -1.92%; 95% CI, -3.94 to 0.09; P = 0.062).</p><p><strong>Conclusion: </strong>In the early post-KTx period, the TNFRSF11A rs884205 risk allele may be associated with greater annualized BMD-FN decline, although this did not persist after baseline BMD-FN adjustment. These findings are preliminary and warrant confirmation in larger cohorts.</p>","PeriodicalId":15116,"journal":{"name":"Journal of Bone and Mineral Metabolism","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2026-10-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149110140","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Treatment-dependent association between sarcopenia and ADL at discharge after osteoporotic vertebral fractures.","authors":"Shunya Mimatsu, Sho Nishida, Shingo Koyama, Iwao Kojima, Yusuke Terao, Shu Tanaka, Kosaku Katsumata, Ryosuke Kita, Keigo Sato, Yushin Yamamoto, Daisuke Fukaya, Itsuo Shiina, Minoru Yamada","doi":"10.1007/s00774-026-01763-7","DOIUrl":"https://doi.org/10.1007/s00774-026-01763-7","url":null,"abstract":"<p><strong>Introduction: </strong>Sarcopenia has been associated with lower activities of daily living (ADL). This study investigated whether sarcopenia at admission is associated with ADL at discharge in patients with osteoporotic vertebral fractures (OVF) and whether this differs by treatment (conservative or balloon kyphoplasty, BKP).</p><p><strong>Materials and methods: </strong>This prospective cohort study included 78 patients with OVF (76.8% female; mean age 83.0 ± 6.7 years). Sarcopenia was defined according to the 2019 Asian Working Group for Sarcopenia criteria, requiring low skeletal muscle mass and low handgrip strength. The outcome was ADL at discharge. Multivariate regression analyses were performed after adjusting for age, sex, mini-mental state examination (MMSE), functional independence measure (FIM-M) at admission, and geriatric nutritional risk index (GNRI). An interaction term (sarcopenia × treatment) was included to examine treatment-dependent associations.</p><p><strong>Results: </strong>Multivariate analysis revealed a significant association between sarcopenia at admission and lower FIM-M at discharge (B = - 11.77, β = - 0.36, 95% CI = - 20.47 to - 3.07, P = 0.009). A significant interaction between sarcopenia and treatment was also detected (B = 5.81, β = 0.40, 95% CI = 0.02 to 11.60, P = 0.049), indicating that the association between sarcopenia and FIM-M at discharge differed with treatment modality.</p><p><strong>Conclusion: </strong>Sarcopenia at admission correlated with ADL at discharge in patients with OVF. This association was modified by treatment modality, with the negative association attenuated in patients undergoing BKP.</p>","PeriodicalId":15116,"journal":{"name":"Journal of Bone and Mineral Metabolism","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2026-10-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149110179","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Lean and fat mass associations with areal bone mineral density in adolescent team sport athletes.","authors":"Pontus Öhrner, Nicolas Pillon, Marcus Bohlin, Per Jonsson, Christer Malm, Michael Svensson","doi":"10.1007/s00774-026-01760-w","DOIUrl":"https://doi.org/10.1007/s00774-026-01760-w","url":null,"abstract":"<p><strong>Introduction: </strong>Adolescence is a critical period for skeletal development, yet in adolescent athletes the relative contribution of lean and fat mass to areal bone mineral density (aBMD) across skeletal sites remains unclear. This cross-sectional study examined sex-specific differences in body composition and aBMD and evaluated the relative associations of lean and fat mass with aBMD in adolescent team sport athletes.</p><p><strong>Materials and methods: </strong>Two hundred two adolescent athletes (126 boys, 76 girls; 16.4 ± 0.4 years) underwent whole-body dual-energy X-ray absorptiometry. Appendicular lean mass index and fat mass index were derived, and aBMD was assessed at the total body, lumbar spine (L1-L4), and femoral neck. Multivariable linear regression models with sex interaction terms and linear contrasts were applied.</p><p><strong>Results: </strong>Appendicular lean mass index was positively associated with total body and lumbar spine aBMD in both sexes (p < 0.05), and with femoral neck aBMD in boys. Fat mass index was not significantly associated with aBMD at any site. No sex × body composition interactions were observed. The relative magnitude of lean and fat mass associations could not be statistically distinguished at lumbar spine and femoral neck (p > 0.05). In the combined model, explanatory power for total body, lumbar spine and femoral neck was R² = 0.29, 0.18 and 0.05, respectively.</p><p><strong>Conclusion: </strong>These findings indicate that lean mass is a group-level correlate of aBMD, but the strength and separability of lean and fat mass associations vary across skeletal sites, with limited ability to distinguish their relative contributions at clinically relevant regions.</p>","PeriodicalId":15116,"journal":{"name":"Journal of Bone and Mineral Metabolism","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149110165","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparative effects of roxadustat and epoetin beta on lumbar trabecular BMD in dialysis patients.","authors":"Mostafa Alaskary, Mohamed A Sobh, Mohamed Ashraf Fouda, Dina Abd Elnasser Rizk, Aya Atef Warda, Wael Ibrahim Mortada, Mohamed Maher Elashmawy, Mohamed Abdalbary","doi":"10.1007/s00774-026-01767-3","DOIUrl":"https://doi.org/10.1007/s00774-026-01767-3","url":null,"abstract":"<p><strong>Introduction: </strong>Anemia treatment agents may have effects beyond hemoglobin, yet whether hypoxia-inducible factor prolyl hydroxylase inhibition influences bone in dialysis remains uncertain. We compared roxadustat with epoetin beta for lumbar trabecular volumetric bone mineral density (vBMD) measured by quantitative computed tomography (QCT).</p><p><strong>Materials and methods: </strong>In this single-center, open-label, exploratory randomized trial, 46 adults receiving maintenance hemodialysis were assigned 1:1 to roxadustat or epoetin beta for 6 months. The primary outcome was the baseline-adjusted between-group difference in average lumbar trabecular vBMD at 6 months. Vertebral-level analyses were exploratory.</p><p><strong>Results: </strong>All participants completed follow-up. Adjusted mean average lumbar vBMD at 6 months was 159 mg/cm³ with roxadustat and 152 mg/cm³ with epoetin beta. The adjusted difference was 7.75 mg/cm³ (95% confidence interval [CI] -10.9 to 26.4; p = 0.406). L1 vBMD was nominally higher with roxadustat (adjusted difference 39.3 mg/cm³, 95% CI 5.2-73.4; p = 0.025), but this finding did not remain statistically significant after multiplicity adjustment (q = 0.124). No significant between-group differences were observed at L2-L5. No adverse events occurred.</p><p><strong>Conclusion: </strong>Roxadustat did not demonstrate superiority over epoetin beta for average lumbar trabecular vBMD over 6 months. These randomized QCT-based estimates address an important evidence gap and may inform larger, longer-term skeletal studies in dialysis.</p><p><strong>Trial registration: </strong>ClinicalTrials.gov NCT06917950; registered 27 March 2025.</p>","PeriodicalId":15116,"journal":{"name":"Journal of Bone and Mineral Metabolism","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2026-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149080770","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}