Journal of Bone and Mineral Metabolism最新文献

{"title":"Time-dependent improvement of quality of life with teriparatide or alendronate therapy: a JOINT-05 sub-analysis.","authors":"Satoshi Mori, Shiro Tanaka, Tatsuhiko Kuroda, Hiroshi Hagino, Satoshi Soen","doi":"10.1007/s00774-025-01621-y","DOIUrl":"https://doi.org/10.1007/s00774-025-01621-y","url":null,"abstract":"<p><strong>Introduction: </strong>The effects of teriparatide (TPTD) and alendronate (ALN) on health-related quality of life (HRQOL) were evaluated in osteoporotic patients with high fracture risk using data from the JOINT-05 trial.</p><p><strong>Materials and methods: </strong>JOINT-05 was a randomized, controlled trial comparing the fracture prevention effects of sequential therapy with TPTD for 72 weeks followed by ALN for 48 weeks with those of ALN monotherapy for 120 weeks. This sub-analysis evaluated the effects of TPTD and ALN on HRQOL using data from baseline to 72 weeks. HRQOL was assessed at baseline, 4, 12, 24, 48, and 72 weeks using the EuroQoL-5Dimension (EQ-5D) questionnaire containing five domains (mobility, self-care, usual activities, pain/discomfort, and anxiety/depression). Scores were also transformed using utility weights derived from the general Japanese population.</p><p><strong>Results: </strong>This sub-analysis included 476 patients in the TPTD group and 492 patients in the ALN group. No significant differences in utility scores were observed between groups at all times. Utility scores improved significantly after 12 weeks in the TPTD group and after 24 weeks in the ALN group. Mobility and self-care scores improved significantly in the TPTD group. Significant improvements in usual activity, pain/discomfort, and anxiety/depression scores occurred earlier in the TPTD group.</p><p><strong>Conclusion: </strong>Although there were no significant differences in utility scores between the TPTD and ALN groups, significant improvements in the utility score and 5 domain scores were observed earlier in the TPTD group. When treating osteoporosis patients with a high risk of fracture, the selecting treatment drugs may be decided with primary consideration of its effect on fracture prevention, followed by its effect on improving HRQOL.</p>","PeriodicalId":15116,"journal":{"name":"Journal of Bone and Mineral Metabolism","volume":" ","pages":""},"PeriodicalIF":2.2,"publicationDate":"2025-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144760138","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Independent risk factors and survival prediction in hip refractures patients: insights from a 10-year cohort.","authors":"Ruilong Qi, Guohong Xu, Zhengtong Lin, Li-Hong Wang","doi":"10.1007/s00774-025-01616-9","DOIUrl":"https://doi.org/10.1007/s00774-025-01616-9","url":null,"abstract":"<p><strong>Introduction: </strong>Hip fracture (HF) is one of the leading causes of mortality and disability in older populations. Hip refracture (HRF) is more serious than HF. We examined the survival rates of patients with HRFs at the Affiliated Dongyang Hospital of Wenzhou Medical University and developed a prediction model for their survival outcomes.</p><p><strong>Materials and methods: </strong>This study involved identifying and analyzing patients with HRFs from January 2013 to August 2023. Utilizing our hospital's database, we systematically extracted these patients' information. We monitored the survival time and constructed Kaplan-Meier (K-M) survival curve. Through Cox proportional hazards regression analyses, independent risk factors were identified. Based on these factors, a survival prediction model was developed and its reliability was evaluated by the receiver operating characteristic (ROC) curve. In addition, patients who refused surgery were excluded, the eligible patients were divided into a long waiting group (> 48 h) and a short waiting group (≤ 48 h). According to a similar process, independent risk factors were identified. Another nomogram chart and ROC curve were conducted.</p><p><strong>Results: </strong>Data from 174 patients were used, presenting a median survival time of 40 months. Both univariate and multivariate analyses identified age (HR = 1.71, 95% CI: 1.26-2.32), surgical intervention (HR = 0.34, 95% CI: 0.21-0.55), number of comorbidities (HR = 1.44, 95% CI: 1.09-1.92) and lymphocyte levels (HR = 0.75, 95% CI: 0.61-0.92) as independent influence factors. Based on these factors, a nomogram chart was constructed. The areas under the ROC curve for predicting 1-year, 2-year, and 3-year survival rates were 0.748, 0.794 and 0.806 respectively. Additionally, through regression analysis of surgical patients, some factors (age, number of comorbidities and lymphocyte levels) were supported as independent influence factors.</p><p><strong>Conclusion: </strong>Advanced age, non-surgical management, multiple comorbidities and lower lymphocyte levels showed a higher risk of all-cause mortality among the patients with HRFs, and these factors were associated with a poor prognosis in this patient population. This study may be useful for improving these patients' prognosis.</p>","PeriodicalId":15116,"journal":{"name":"Journal of Bone and Mineral Metabolism","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-07-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144659269","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Response to the letter regarding \"Increased complications of proximal femur fractures during the COVID-19 pandemic\".","authors":"Hidetatsu Tanaka, Kunio Tarasawa, Yu Mori, Kiyohide Fushimi, Kenji Fujimori, Toshimi Aizawa","doi":"10.1007/s00774-025-01628-5","DOIUrl":"https://doi.org/10.1007/s00774-025-01628-5","url":null,"abstract":"","PeriodicalId":15116,"journal":{"name":"Journal of Bone and Mineral Metabolism","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-07-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144667706","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Author's response to letter to the editor: Re: Randomized crossover comparison of two teriparatide self-injection regimens for primary osteoporosis: interim report of JOINT-06.","authors":"Satoshi Soen, Yukari Uemura, Shiro Tanaka, Yasuhiro Takeuchi, Naoto Endo, Junichi Takada, Satoshi Ikeda, Jun Iwamoto, Nobukazu Okimoto, Sakae Tanaka","doi":"10.1007/s00774-025-01627-6","DOIUrl":"https://doi.org/10.1007/s00774-025-01627-6","url":null,"abstract":"","PeriodicalId":15116,"journal":{"name":"Journal of Bone and Mineral Metabolism","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-07-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144667705","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A critique on \"Bisphosphonates with high bone‑resorption‑capacity promote osteonecrosis of the jaw development after tooth extraction in mice\".","authors":"Sabtain Shah, Shafiullah, Muhammad Arif Khan, Ziad Khan, Mohsin Ali, Saqlain Shah, Bilal Ahmad","doi":"10.1007/s00774-025-01620-z","DOIUrl":"10.1007/s00774-025-01620-z","url":null,"abstract":"","PeriodicalId":15116,"journal":{"name":"Journal of Bone and Mineral Metabolism","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144649570","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Critical insights on \"Non‑contact electrical stimulation via a vector‑potential transformer promotes bone healing in drill‑hole injury model\".","authors":"Bilal Ahmad, Maryam Asghar Jamal, Alsa Umar","doi":"10.1007/s00774-025-01618-7","DOIUrl":"10.1007/s00774-025-01618-7","url":null,"abstract":"","PeriodicalId":15116,"journal":{"name":"Journal of Bone and Mineral Metabolism","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144642635","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Critical appraisal of \"unexplored limitations in the study of proximal femur fractures during the COVID-19 pandemic\".","authors":"Shafi Ullah, Muhsin Ali, Ziad Khan, Muhammad Arif Khan, Sabtain Shah, Mohsin Ali","doi":"10.1007/s00774-025-01623-w","DOIUrl":"10.1007/s00774-025-01623-w","url":null,"abstract":"","PeriodicalId":15116,"journal":{"name":"Journal of Bone and Mineral Metabolism","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144642634","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Critical insights on bisphosphonates with high bone-resorption-capacity promote osteonecrosis of the jaw development after tooth extraction in mice.","authors":"Iman Karim, Bilal Ahmad, Sadeeq Khan, Muneeb Ullah","doi":"10.1007/s00774-025-01622-x","DOIUrl":"10.1007/s00774-025-01622-x","url":null,"abstract":"","PeriodicalId":15116,"journal":{"name":"Journal of Bone and Mineral Metabolism","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144642636","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comment on \"Randomized crossover comparison of two teriparatide self‑injection regimens for primary osteoporosis: interim report of JOINT-06\".","authors":"Rafiqur Rahman, Bilal Ahmed, Aysha Habib","doi":"10.1007/s00774-025-01625-8","DOIUrl":"10.1007/s00774-025-01625-8","url":null,"abstract":"","PeriodicalId":15116,"journal":{"name":"Journal of Bone and Mineral Metabolism","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144642633","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Probability of achieving treatments goals with twice-weekly teriparatide followed by bisphosphonate in Japanese postmenopausal osteoporosis.","authors":"Junichi Takada, Kousuke Iba, Tsuneo Takebayashi, Megumi Hanaka, Tomohiro Akatsuka, Atsushi Teramoto","doi":"10.1007/s00774-025-01626-7","DOIUrl":"https://doi.org/10.1007/s00774-025-01626-7","url":null,"abstract":"<p><strong>Introduction: </strong>The purpose of this study is to evaluate the increase in bone mineral density (BMD) and achievement of treatment goals based on the ASBMR/BHOF position statement over 3 years of sequential therapy with 2 years of twice-weekly teriparatide (2/W TPTD) followed by 1 year of bisphosphonate (BP) therapy.</p><p><strong>Materials and methods: </strong>This was a multicenter, retrospective study. Thirty-eight postmenopausal patients with primary osteoporosis at very high risk of fracture according to the Diagnostic Criteria for Primary Osteoporosis in Japan were enrolled. Changes in BMD at the lumbar spine (LS) and total hip (TH) were evaluated. Patients were divided into the naïve group (no history of osteoporosis treatment) and the pre-BP group (prior BP treatment). The treatment goals were assessed using the BMD T-score as follows; Baseline T-score ≤ - 2.5: Greater than - 2.5 at 3 years and baseline T-score > - 2.5: Increase at least 0.5 for LS and 0.2 for TH.</p><p><strong>Results: </strong>The naïve group showed a significant increase in LS-BMD and TH-BMD of 14.6% and 4.8%, respectively, and the pre-BP group only showed a significant increase in LS-BMD of 8.4% over 3 years. In the naïve group, 60.7% (17/28) achieved the treatment goal for LS-BMD, and 39.3% (11/28) achieved for TH-BMD. In the pre-BP group, 50.0% (4/8) achieved the treatment goal for LS-BMD, but no patient achieved the goal for TH-BMD.</p><p><strong>Conclusion: </strong>After 3 years of sequential therapy from 2/W TPTD to BP, 50% or more of the patients achieved the treatment goal in the LS-BMD but not in the TH-BMD.</p>","PeriodicalId":15116,"journal":{"name":"Journal of Bone and Mineral Metabolism","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144642637","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}