Journal of Bone and Mineral Metabolism最新文献

{"title":"Lactate and lactylation in osteoporosis: pathogenesis, regulation, and future perspectives.","authors":"Jianhao Sun, Miao Ge, Peng Gao, Nan Zhang, Tingting Huang, Tao Liu","doi":"10.1007/s00774-026-01722-2","DOIUrl":"https://doi.org/10.1007/s00774-026-01722-2","url":null,"abstract":"<p><p>Osteoporosis is a metabolic bone disease characterized by bone microstructural degeneration and increased fracture risk, primarily driven by an imbalance in bone homeostasis. Recent studies have revealed that lactate metabolic remodeling and its derived lactylation modifications play a pivotal role in the dynamic balance between bone formation and resorption by regulating the metabolic-epigenetic network within the bone microenvironment. This review systematically examines the role of lactate metabolic pathways in the energy reprogramming of osteoblasts, analyzes the molecular mechanisms of lactylation in osteogenesis-osteoclastogenesis coupling, and discusses the challenges and future directions of novel therapeutic strategies targeting the lactate metabolism axis. By elucidating the critical role of lactate metabolism in the pathogenesis of osteoporosis, this review aims to enhance comprehensive understanding and facilitate the development of effective therapeutic interventions.</p>","PeriodicalId":15116,"journal":{"name":"Journal of Bone and Mineral Metabolism","volume":" ","pages":""},"PeriodicalIF":2.2,"publicationDate":"2026-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147639063","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comment on \"Bone fragility and atypical femoral fractures in SLE: role of disease activity, infection, and treatment\".","authors":"Manish Juneja, Harshawardhan Ramteke, Rakhshanda Khan","doi":"10.1007/s00774-026-01718-y","DOIUrl":"10.1007/s00774-026-01718-y","url":null,"abstract":"","PeriodicalId":15116,"journal":{"name":"Journal of Bone and Mineral Metabolism","volume":" ","pages":""},"PeriodicalIF":2.2,"publicationDate":"2026-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147573994","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Author's Response to letter to the editor \"Commentary on: the effects of sequential therapy using anti-resorptive agents after administering once-weekly teriparatide or twice-weekly teriparatide\" (JBMM-D-26-00062).","authors":"Hidehiro Matsumoto, Manabu Tsukamoto, Nobukazu Okimoto, Satoshi Ikeda, Masahiro Tanaka, Mitsugu Takahashi, Yoshiaki Ikejiri, Fumihiro Oha, Satoshi Mizuno, Keiichi Shigenobu, Akinori Sakai, Junichi Takada","doi":"10.1007/s00774-026-01717-z","DOIUrl":"https://doi.org/10.1007/s00774-026-01717-z","url":null,"abstract":"","PeriodicalId":15116,"journal":{"name":"Journal of Bone and Mineral Metabolism","volume":" ","pages":""},"PeriodicalIF":2.2,"publicationDate":"2026-03-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147503849","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Identification of potential diagnostic and therapeutic apoptosis-related casual targets for osteoporosis: an integrated multi-omics analysis.","authors":"Yixi Wang, Lintao Xia, Yang Xiao, Mingxing Wu, Rui Zhang, Paerhati Rexiti, Hui Zhang","doi":"10.1007/s00774-026-01710-6","DOIUrl":"https://doi.org/10.1007/s00774-026-01710-6","url":null,"abstract":"<p><strong>Introduction: </strong>Apoptosis plays a significant role in osteoporosis (OP), yet a causal relationship between apoptosis gene expressions and OP remains unexplored. This study applies an integrated multi-omics analysis to establish causality between them, offering clinical treatment and prediction insights.</p><p><strong>Materials and methods: </strong>Apoptosis-related genes are sourced from GeneCards, and 6 transcriptomic datasets from the cells in the circulation are obtained from GEO. Meta-analysis integrated differentially expressed apoptosis-related genes (DEGs) from the above 6 datasets. Causality between gene expressions, epigenetic changes, and OP is examined using OP genome-wide association study (GWAS), plasma expression quantitative trait loci (eQTL), and methylation quantitative trait loci (mQTL) data, while analysis of skeletal muscle eQTL and OP GWAS data is conducted. External validation is performed with the UK Biobank datasets.</p><p><strong>Results: </strong>Meta-analysis of 6 GEO datasets identified 384 DEGs, including 78 apoptosis-related genes. The three-step analysis indicates 8 candidate causal genes in blood, including MAP3K3, DPP8, RPL3, PPP2CA, CD86, LRRFIP1, TRAP1, and DUSP6, with LRRFIP1 influenced by four methylation sites. Analysis of skeletal muscle data reveals 4 causal genes, including SIPA1L3, PDLIM7, CTNNB1, and DPP8. Among apoptosis-related genes causally linked to OP in both circulation and skeletal muscle, LRRFIP1 was validated based on methylation-associated regulation and demonstrated consistent, reproducible expression patterns.</p><p><strong>Conclusions: </strong>This study uses a multi-omics strategy to clarify the roles of apoptosis-related gene expressions and their corresponding methylation in OP, providing targets and a basis for early diagnosis, personalized treatment, and monitoring of OP.</p>","PeriodicalId":15116,"journal":{"name":"Journal of Bone and Mineral Metabolism","volume":" ","pages":""},"PeriodicalIF":2.2,"publicationDate":"2026-03-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147503929","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Giant cell tumor of bone inhibits osteoblastogenesis via WNT5B.","authors":"Masaki Shimada, Tomonori Tsuyama, Naoto Yoshimura, Makoto Tateyama, Hideto Matsunaga, Fuka Homma, Kasumi Dainobu, Xiao Tian, Shu Takata, Kosei Takata, Shuntaro Tanimura, Yuto Shibata, Kazuya Maeda, Junki Kawakami, Takahiro Arima, Tatsuki Karasugi, Takuya Tokunaga, Hiro Sato, Tetsuro Masuda, Satoshi Hisanaga, Yuki Kai, Soichiro Karata, Hikaru Goshogawa, Rui Tajiri, Hibiki Yamada, Yusuke Uehara, Takayuki Nakamura, Masaki Yugami, Kazuki Sugimoto, Ryuji Yonemitsu, Hironori Tanoue, Kazuya Yamagata, Takeshi Miyamoto","doi":"10.1007/s00774-026-01713-3","DOIUrl":"https://doi.org/10.1007/s00774-026-01713-3","url":null,"abstract":"<p><strong>Introduction: </strong>Giant cell tumor of bone (GCTB) induces overproduction of bone-resorbing osteoclasts through receptor activator of nuclear factor kappa B ligand (RANKL), leading to bone resorption and destruction. Consequently, denosumab, a neutralizing antibody against RANKL (a cytokine essential for osteoclast induction), is used to treat patients with GCTB. However, the activity of bone formation in GCTB remains poorly understood. Here, we show that GCTB antagonizes bone formation by expressing WNT5B, which inhibits bone formation.</p><p><strong>Materials and methods: </strong>Co-culture of NCC-GCTB1-C1 (GCTB1s), a human GCTB cell line, with human adipose-derived stem cells (ADSCs) was performed with osteoblast induction medium. To identify the inhibitors of osteoblast differentiation, we reanalyzed the single-cell RNA sequencing data that was previously published. In addition, we performed spatial transcriptome analysis (Visium) against the section of paraffin block of GCTB. The targeted protein was knocked out using CRISPR/Cas9 and co-culture was performed.</p><p><strong>Results: </strong>Co-culture of GCTB1s with ADSCs significantly inhibited mineralization of ADSCs. Reanalysis of single-cell RNA sequencing data indicated that GCTB tumors express WNT5B, and we observed that GCTB1s express WNT5B. We then knocked out WNT5B in GCTB1s using CRISPR/Cas9 and co-cultured them with ADSCs and observed significant rescue of mineralization in ADSCs relative to ADSCs cultured with GCTB1s expressing WNT5B. We also show that ADSC supernatants induce mineralization of GCTB1s.</p><p><strong>Conclusion: </strong>These studies indicate that GCTB not only induces osteoclasts, but also possesses activity that inhibits bone formation.</p>","PeriodicalId":15116,"journal":{"name":"Journal of Bone and Mineral Metabolism","volume":" ","pages":""},"PeriodicalIF":2.2,"publicationDate":"2026-03-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147503873","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Response to the letter to the editor regarding \"treatment with romosozumab in patients with osteoporosis on maintenance hemodialysis\".","authors":"Motohiko Sato","doi":"10.1007/s00774-026-01712-4","DOIUrl":"https://doi.org/10.1007/s00774-026-01712-4","url":null,"abstract":"","PeriodicalId":15116,"journal":{"name":"Journal of Bone and Mineral Metabolism","volume":" ","pages":""},"PeriodicalIF":2.2,"publicationDate":"2026-03-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147504026","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Commentary on \"The effects of sequential therapy using anti-resorptive agents after administering once-weekly teriparatide or twice-weekly teriparatide\".","authors":"Fei Ji, Yizhou Chen","doi":"10.1007/s00774-026-01716-0","DOIUrl":"10.1007/s00774-026-01716-0","url":null,"abstract":"","PeriodicalId":15116,"journal":{"name":"Journal of Bone and Mineral Metabolism","volume":" ","pages":""},"PeriodicalIF":2.2,"publicationDate":"2026-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147493708","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"NEFL is associated with inhibition of odontoblastic process in odontohypophosphatasia.","authors":"Akira Nozoe, Yasuhisa Ohata, Makoto Fujiwara, Kenichi Yamamoto, Toshihiko Nambara, Chiho Nakano, Kazuaki Miyagawa, Mikihiko Kogo, Takeshi Taketani, Takuo Kubota, Yasuji Kitabatake, Susumu Tanaka, Keiichi Ozono","doi":"10.1007/s00774-026-01703-5","DOIUrl":"https://doi.org/10.1007/s00774-026-01703-5","url":null,"abstract":"<p><strong>Introduction: </strong>Hypophosphatasia (HPP) is a rare bone disease caused by pathological variants of ALPL. While hypomineralization of dentin and odontoblast (OD) differentiation defects are known to occur in HPP, the underlying pathophysiology remains poorly understood.</p><p><strong>Materials and methods: </strong>We generated induced pluripotent stem cell (iPSC) lines from patients with perinatal severe HPP (Perinatal) and then isogenic (Rescued) and odontohypophosphatasia type (Odonto) lines using gene editing. These three HPP-iPSC lines were differentiated into OD-like cells via mesenchymal stem cells derived from neural crest cells. The characteristics of the OD-like cells were assessed.</p><p><strong>Results: </strong>Rescued-OD-like cells demonstrated mineralization ability, increased microtubule-associated protein tau (MAPT) expression, and unidirectional cell processes, while these characteristics were impaired in Perinatal- and Odonto-OD-like cells. These findings suggest that these features are associated with reduced ALP activity. Notably, neurofilament light chain (NEFL) expression was enhanced in Odonto-OD-like cells compared to Perinatal- and Rescued-OD-like cells. NEFL knockdown partially rescued cell process elongation in Odonto-OD-like cells without affecting alkaline phosphatase activity, while NEFL overexpression inhibited cell process elongation in Rescued-OD-like cells.</p><p><strong>Conclusions: </strong>Enhanced expression of NEFL in Odonto-OD-like cells negatively correlates with OD morphology and may be relevant to odontoblast morphological abnormalities associated with odontohypophosphatasia; however, generalization to other odonto-HPP genotypes requires additional patient-derived lines.</p>","PeriodicalId":15116,"journal":{"name":"Journal of Bone and Mineral Metabolism","volume":" ","pages":""},"PeriodicalIF":2.2,"publicationDate":"2026-03-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147457668","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Treatment with romosozumab in patients with osteoporosis on maintenance hemodialysis.","authors":"Michael Pazianas, Paul D Miller","doi":"10.1007/s00774-026-01711-5","DOIUrl":"10.1007/s00774-026-01711-5","url":null,"abstract":"","PeriodicalId":15116,"journal":{"name":"Journal of Bone and Mineral Metabolism","volume":" ","pages":""},"PeriodicalIF":2.2,"publicationDate":"2026-03-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147443816","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Inverse association between diet quality and the risk of osteoporotic fractures: a cross-sectional analysis.","authors":"Xi Liu, Bin Xu","doi":"10.1007/s00774-026-01705-3","DOIUrl":"https://doi.org/10.1007/s00774-026-01705-3","url":null,"abstract":"<p><strong>Introduction: </strong>This study aimed to systematically evaluate the association between the Healthy Eating Index (HEI-2020), the Alternative Healthy Eating Index (AHEI), and the risk of osteoporotic fractures based on the National Health and Nutrition Examination Survey (NHANES) database.</p><p><strong>Materials and methods: </strong>We included 13,541 participants from NHANES data, of whom 1,646 experienced osteoporotic fractures. Diet quality was assessed using HEI-2020 and AHEI scores. Weighted multivariable logistic regression, restricted cubic spline (RCS) analysis, and subgroup analyses were applied to evaluate the relationship between HEI-2020, AHEI, and osteoporotic fracture risk.</p><p><strong>Results: </strong>After full adjustment for confounding factors, each 1-point increase in HEI-2020 and AHEI scores was associated with a 1.5% (OR = 0.985, 95% CI: 0.978-0.992) and 1.3% (OR = 0.987, 95% CI: 0.980-0.994) reduction in osteoporotic fracture risk, respectively. RCS analysis indicated that both HEI-2020 (p for nonlinear = 0.2911) and AHEI (p for nonlinear = 0.3951) were linearly and inversely associated with osteoporotic fracture risk (all P overall < 0.0001). Subgroup analyses showed that this association remained consistent across populations stratified by sex, age, BMI, smoking status, hypertension, diabetes, and cardiovascular disease, with no significant interactions observed. Sensitivity analyses excluding participants who reported the use of prescription medications for hypertension or diabetes yielded results consistent with the primary analyses after multivariable adjustment.</p><p><strong>Conclusion: </strong>This study systematically showed a significant inverse association between HEI-2020, AHEI, and osteoporotic fracture risk. The findings suggest that improving diet quality may be a feasible strategy for preventing osteoporotic fractures, with broad population applicability and public health implications.</p>","PeriodicalId":15116,"journal":{"name":"Journal of Bone and Mineral Metabolism","volume":" ","pages":""},"PeriodicalIF":2.2,"publicationDate":"2026-03-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147443809","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}