Journal of Bone and Mineral Metabolism最新文献

{"title":"Pharmacological management of knee and hip osteoarthritis stratified by oral nonsteroidal anti-inflammatory drugs safety status.","authors":"Masaki Hatano, Yuya Kimura, Akira Okada, Hisatoshi Ishikura, Takeyuki Tanaka, Sakae Tanaka, Hideo Yasunaga","doi":"10.1007/s00774-026-01762-8","DOIUrl":"https://doi.org/10.1007/s00774-026-01762-8","url":null,"abstract":"<p><strong>Introduction: </strong>Knee and hip osteoarthritis are treated with oral nonsteroidal anti-inflammatory drugs (NSAIDs); however, pharmacological management by NSAID safety status remains unclear. We characterized pharmacological treatment patterns across safety strata.</p><p><strong>Materials and methods: </strong>We used Japanese health insurance claims database (2014-2024). Adults aged ≥40 years with incident knee or hip osteoarthritis were classified as having oral NSAID contraindications, precautions, or neither. Outcomes were receipt of oral NSAIDs within 90 days of osteoarthritis diagnosis. Adjusted risk differences (RDs) were estimated with identity-link binomial models and facility-clustered standard errors.</p><p><strong>Results: </strong>For knee osteoarthritis, oral NSAIDs were prescribed to 49.0%, 44.0%, and 30.2% of patients in the no contraindications or precautions, precaution, and contraindication groups, respectively, and to 53.4%, 48.6%, and 34.5% of patients with hip osteoarthritis. Compared with patients with no contraindications or precautions, the adjusted RDs for receiving oral NSAIDs were -2.0 (95% confidence interval [CI], -2.6 to -1.4) and -12.9 (95% CI -14.1 to -11.7) for knee osteoarthritis, and -1.9 (95% CI -3.3 to -0.5) and -13.0 (95% CI -15.7 to -10.3) for hip osteoarthritis, for the precaution and contraindication groups, respectively. Adjusted RDs for receiving non-NSAID treatments were 0.5 (95% CI -0.1 to 1.1) and -2.0 (95% CI -3.4 to -0.6) for knee osteoarthritis, and 1.1 (95% CI -0.2 to 2.3) and 3.1 (95% CI 0.3 to 5.8) for hip osteoarthritis, respectively.</p><p><strong>Conclusion: </strong>Oral NSAID use was less frequent among patients classified as having oral NSAID precautions or contraindications than among those without such classifications in both cohorts.</p>","PeriodicalId":15116,"journal":{"name":"Journal of Bone and Mineral Metabolism","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2026-09-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149069669","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Validity of Bone Mineral Density Measurements Using SONIALVISION G4: A Quantitative CT-based Evaluation.","authors":"Junichiro Morita, Keisuke Uemura, Sotaro Kono, Yi Gu, Yuto Nishioka, Tomoki Asano, Ryo Higuchi, Hirokazu Mae, Makoto Iwasa, Tetsuro Tani, Kazuma Takashima, Kazunori Tamura, Takeshi Ogawa, Wataru Ando, Takeshi Ogawa, Yoshito Otake, Seiji Okada, Hidetoshi Hamada","doi":"10.1007/s00774-026-01766-4","DOIUrl":"https://doi.org/10.1007/s00774-026-01766-4","url":null,"abstract":"<p><strong>Introduction: </strong>SONIALVISION G4 is a fluoroscopic imaging system equipped with a bone densitometry function calibrated against GE Healthcare dual-energy X-ray absorptiometry (DXA) measurements. However, evidence supporting the validity of in vivo bone mineral density (BMD) measurements remains limited. This study compared BMD measurements obtained using SONIALVISION G4 with GE DXA reference data and evaluated their validity using quantitative computed tomography (CT).</p><p><strong>Materials and methods: </strong>A total of 887 BMD examinations performed with SONIALVISION G4 in women aged ≥45 years were compared with published Japanese reference data obtained using GE DXA. CT-derived BMD was quantified using a validated deep learning-based method and compared with measurements obtained using SONIALVISION G4 in 30 patients. To validate the CT method against GE DXA, 697 patients from four additional institutions underwent GE DXA and CT. Analyses were conducted for both the femoral neck and total hip.</p><p><strong>Results: </strong>Femoral neck BMD generally showed small differences from the reference values, whereas total hip BMD was consistently higher in women aged ≥55 years. CT-derived BMD correlated with SONIALVISION G4 measurements (r = 0.762 and 0.842 for the femoral neck and total hip, respectively), with median absolute differences of 0.022 and 0.133 g/cm². In contrast, CT-derived BMD showed very strong correlations with GE DXA (r = 0.913 and 0.959) and smaller absolute differences (0.043 and 0.033 g/cm²).</p><p><strong>Conclusion: </strong>SONIALVISION G4 showed small differences in femoral neck BMD measurements compared with CT-derived measurements but may systematically overestimate total hip BMD. Further validation studies are warranted.</p>","PeriodicalId":15116,"journal":{"name":"Journal of Bone and Mineral Metabolism","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2026-09-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149069641","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comment on \"Eldecalcitol and calcium supplementation in Chinese women with postmenopausal osteoporosis: a prospective observational cohort study\".","authors":"Saleha Eman, Maryam Ijaz, Muhammad Shaharyar Sabeeh","doi":"10.1007/s00774-026-01769-1","DOIUrl":"10.1007/s00774-026-01769-1","url":null,"abstract":"","PeriodicalId":15116,"journal":{"name":"Journal of Bone and Mineral Metabolism","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2026-09-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149069679","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Performance of screening tools for osteoporosis and fractures in community-dwelling elderly Japanese men.","authors":"Yuki Fujita, Junko Tamaki, Katsuyasu Kouda, Yuho Sato, Nozomi Okamoto, Masayuki Iki","doi":"10.1007/s00774-026-01768-2","DOIUrl":"https://doi.org/10.1007/s00774-026-01768-2","url":null,"abstract":"<p><strong>Introduction: </strong>The Osteoporosis Self-Assessment Tool for Asians (OSTA) was originally developed for postmenopausal Asian women, but its performance in men is inadequately characterized. This study evaluated the diagnostic accuracy of OSTA for identifying osteoporosis and predicting major osteoporotic fractures (MOF) in elderly Japanese men, and compared its fracture prediction capability with the fracture risk assessment tool (FRAX^®).</p><p><strong>Materials and methods: </strong>Data were drawn from the Fujiwara-kyo Osteoporosis Risk in Men (FORMEN) cohort. The primary analysis included 1888 men aged 65-94 years. Osteoporosis was defined by dual-energy X-ray absorptiometry (DXA)-derived T-score ≤-2.5 at the lumbar spine, total hip, or femoral neck. OSTA and FRAX^® 10-year MOF probability were calculated at baseline. Optimal cutoff values were determined using the Youden index. A sub-analysis for MOF prediction was conducted in 866 men with 10-year follow-up data.</p><p><strong>Results: </strong>The area under the curve (AUC) of OSTA for identifying osteoporosis was 0.777 (95% CI 0.714-0.840) in men aged 65-74 years and 0.739 (95% CI 0.666-0.812) in those aged ≥75 years. Optimal OSTA cutoff values (- 3 and -5, respectively) differed substantially from the conventional female-derived threshold of ≤-1. For MOF prediction, the AUC of OSTA was not significantly different from that of FRAX^®.</p><p><strong>Conclusion: </strong>OSTA demonstrated moderate discriminative ability for DXA-defined osteoporosis in elderly Japanese men; however, age-specific cutoff values are required. The comparable fracture prediction performance of OSTA and FRAX^® supports the utility of this simple index as a first-line screening tool in men.</p>","PeriodicalId":15116,"journal":{"name":"Journal of Bone and Mineral Metabolism","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2026-09-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149069650","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Shared genetic basis of sarcopenia and osteoporosis: insights from GWAS and multi-omics analyses.","authors":"Kaixi Ding, Youheng Zhao, Wei Jiang, Ming Lei, Qiang Ren, Yongxiang Gao","doi":"10.1007/s00774-026-01757-5","DOIUrl":"https://doi.org/10.1007/s00774-026-01757-5","url":null,"abstract":"<p><strong>Introduction: </strong>Sarcopenia and osteoporosis are common age-related disorders, and their coexistence increases fracture risk and premature mortality. The shared genetic architecture of these conditions remains unclear.</p><p><strong>Materials and methods: </strong>Genome-wide association study (GWAS) summary statistics from four sarcopenia-related traits were used to construct a latent factor model for sarcopenia. Osteoporosis GWAS data came from the UK Biobank and FinnGen. Linkage disequilibrium score regression and MiXeR were used to assess genetic correlation and polygenic overlap between sarcopenia and osteoporosis. Shared variants were identified via conjunctional false discovery rate (conjFDR). Key genes were analyzed with functional annotation, predicted expression, Mendelian randomization, and colocalization, and integrated with single-cell and spatial transcriptomics to reveal cell-type-specific expression and spatial patterns.</p><p><strong>Results: </strong>Sarcopenia and osteoporosis showed a significant positive genetic correlation (rg = 0.1104, P = 1.76E-09). MiXeR estimated ~753 shared genetic variants (Dice = 0.315). conjFDR analysis identified 34 shared lead single-nucleotide polymorphisms. MetaXcan prioritized 4 and 6 comorbidity genes in subcutaneous adipose tissue and skeletal muscle, respectively (FDR < 0.05). CCND2 and CYTH1 had significant causal effects on both conditions, with colocalization indicating concordant causal variants (posterior probability of hypothesis 4 > 0.9). Genetic signals were enriched in bone- and muscle-related tissues, and CCND2 (cartilage primordium) and GRB10 (muscle) showed high tissue-specific expression for both traits.</p><p><strong>Conclusion: </strong>Sarcopenia and osteoporosis are genetically correlated, sharing multiple polygenic signals and key comorbidity genes. Genetic effects mainly act through bone- and muscle-related tissues, supporting a shared genetic basis and potential mechanisms of bone-muscle comorbidity.</p>","PeriodicalId":15116,"journal":{"name":"Journal of Bone and Mineral Metabolism","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2026-09-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149016532","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dietary mineral insufficiency and osteoporosis risk across skeletal sites in older Iranian adults: IMOS-2021.","authors":"Faezeh Sehatpour, Farima Farsi, Arash Ghazbani, Mahnaz Sanjari, Kazem Khalagi, Atefeh Amrollahi Bioky, Samaneh Akbarpour, Hamidreza Aghaei Meybodi, Nazli Namazi, Afshin Ostovar, Noushin Fahimfar, Bagher Larijani","doi":"10.1007/s00774-026-01754-8","DOIUrl":"https://doi.org/10.1007/s00774-026-01754-8","url":null,"abstract":"<p><strong>Introduction: </strong>The aim of this study was to examine Iranian adults aged 50 and above to determine the association between the prevalence of regional osteoporosis and their dietary intake of phosphorus, magnesium, potassium, and zinc.</p><p><strong>Materials and methods: </strong>We conducted a cross-sectional analysis of 1353 participants (406 with osteoporosis, 947 healthy) from the Iranian Multicenter Osteoporosis Study (IMOS-2021). A validated 168-item food frequency questionnaire was utilized to evaluate dietary intake. The lumbar spine, whole hip, and femoral neck were assessed for bone mineral density (BMD) with dual-energy x-ray absorptiometry. Multivariable logistic regression models were used to estimate odds ratios (ORs) for osteoporosis, adjusting for potential confounders.</p><p><strong>Results: </strong>Participants with osteoporosis were significantly older (63.76 vs. 59.61 years, P < 0.001), more likely to be women (67.2% vs. 50.4%, P < 0.001), and had lower intakes of all measured minerals (all P < 0.001). Correlation analyses revealed significant positive associations between all minerals and BMD at all skeletal sites (all P ≤ 0.01). In univariable models, insufficient phosphorus intake was associated with spine osteoporosis (OR = 1.56, P = 0.006) and total osteoporosis (OR = 1.49, P = 0.008), while insufficient potassium intake was linked to total osteoporosis (OR = 1.79, P = 0.031). After adjustment, only insufficient phosphorus intake remained significant for spine osteoporosis (OR = 1.71, P = 0.008).</p><p><strong>Conclusion: </strong>Our findings suggest that dietary phosphorus may be independently associated with osteoporosis risk in this population; however, prospective studies incorporating objective dietary assessment, broader lifestyle factors, and fracture-related outcomes are needed to confirm causality and address residual confounding.</p>","PeriodicalId":15116,"journal":{"name":"Journal of Bone and Mineral Metabolism","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2026-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148864940","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of dual-energy X-ray absorptiometry and lumbar radiographs using deep learning for osteoporosis diagnosis.","authors":"Deniz Apalan, Bulent Yildiz, Ozlem Polat, Irfan Atik, Ismail Salk","doi":"10.1007/s00774-026-01752-w","DOIUrl":"https://doi.org/10.1007/s00774-026-01752-w","url":null,"abstract":"<p><strong>Introduction: </strong>Osteoporosis and osteopenia, characterized by reduced bone mineral density (BMD), increase fracture risk, particularly in older adults. Early detection is critical for preventing fractures and preserving quality of life. Variability in radiographic interpretation highlights the need for automated diagnostic approaches. This study evaluates whether deep learning (DL) analysis of lumbar radiographs can serve as an alternative to dual-energy X-ray absorptiometry (DEXA) for detecting osteopenia and osteoporosis.</p><p><strong>Materials and methods: </strong>In this retrospective study, 1039 patients (aged 20-95 years, mean 64.99 ± 11.61) who underwent both DEXA and lumbar spine radiography within three months were included. BMD was classified using T-scores for adults over 50, including postmenopausal women and men, and Z-scores for younger participants. Lateral lumbar radiographs (L1-L4) were categorized as normal, osteopenic, or osteoporotic according to DEXA results. Five pretrained transfer learning models (DenseNet-169, EfficientNet-B7, Inception-ResNetV2, ResNet-152V2, Xception) were used for feature extraction, with hyperparameters optimized using the Grey Wolf Optimization (GWO) algorithm. Models were evaluated for both multiclass and binary classification tasks.</p><p><strong>Results: </strong>In multiclass classification, DenseNet169 achieved the highest test AUC of 0.81. In binary classification, Xception (AUC: 0.90) was most effective in distinguishing normal from osteopenia, while InceptionResNetV2 (accuracy: 90.08%) performed best in separating normal from osteoporosis.</p><p><strong>Conclusions: </strong>These results suggest that DL analysis of lumbar radiographs, combined with transfer learning and metaheuristic optimization, may support BMD category classification as a complementary screening tool. This approach may provide a reliable, non-invasive, and accessible alternative to DEXA for osteoporosis screening and diagnosis.</p>","PeriodicalId":15116,"journal":{"name":"Journal of Bone and Mineral Metabolism","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2026-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148850555","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The impact of metabolic syndrome on changes in trunk muscle CSA: a 10-year longitudinal study.","authors":"Yosuke Mano, Eiichiro Nakamura, Manabu Tsukamoto, Takayuki Nabeshima, Toru Nakagawa, Yoichi Murata, Masaru Takeda, Kenichiro Narusawa, Kenji Shimizu, Yoshiaki Yamanaka, Hitoshi Suzuki, Soshi Uchida, Takeshi Hayashi, Akinori Sakai","doi":"10.1007/s00774-026-01750-y","DOIUrl":"https://doi.org/10.1007/s00774-026-01750-y","url":null,"abstract":"<p><strong>Introduction: </strong>Few studies have investigated the relationship between metabolic syndrome (MetS) and muscle loss over a 10-year period in large working populations. This study aimed to investigate the influence of MetS-related and respiratory factors on changes in trunk muscles in the working population.</p><p><strong>Materials and methods: </strong>The cross-sectional areas (CSAs) of the psoas major (PM) and erector spinae (ES) were measured using abdominal low-dose CT imaging at baseline and at 10 years. Predictors of CSA loss were analyzed using multiple linear regression analysis.</p><p><strong>Results: </strong>A total of 1504 males were included. The change in the CSA of the PM at 10 years decreased significantly with increasing age, BMI, abdominal circumference, visceral fat area (VFA), systolic blood pressure (sBP), and HbA1c. The change in the CSA of the ES at 10 years decreased significantly with increasing age, weight, BMI, abdominal circumference, VFA, sBP, HbA1c, and LDL level. Multiple linear regression analysis revealed that VFA and HbA1c were independently associated with PM loss, while a lower percentage vital capacity (%VC) was associated with ES loss. The ratio of forced expiratory volume in one second to forced vital capacity (FEV1.0%) at baseline was identified as a significant predictor of PM loss for individuals with MetS.</p><p><strong>Conclusion: </strong>Among MetS-related factors, VFA and HbA1c were associated with trunk muscle CSA loss over 10 years in the working population. Furthermore, in individuals with MetS, lower FEV1.0% was associated with PM loss.</p>","PeriodicalId":15116,"journal":{"name":"Journal of Bone and Mineral Metabolism","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2026-08-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148793452","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring the causal relationship and pathogenesis of intracranial aneurysms with osteoporosis based on Mendelian randomization and bioinformatics study.","authors":"Feng Chen, Pingyou He, Wei Xu, Danfeng Yu, Chao Luo","doi":"10.1007/s00774-026-01749-5","DOIUrl":"https://doi.org/10.1007/s00774-026-01749-5","url":null,"abstract":"<p><strong>Introduction: </strong>Intracranial aneurysms (IA) and osteoporosis (OP) are both common conditions among the elderly population. Observational studies suggest a potential association between OP and IA. However, the causal relationships and biological mechanisms underlying these associations remain unclear.</p><p><strong>Materials and methods: </strong>We performed bidirectional two-sample Mendelian randomization (TSMR) analysis using summary statistics from European genome-wide association studies. The inverse variance weighted (IVW) method served as the primary approach for causal inference. Furthermore, sensitivity analyses were conducted to evaluate the potential level of heterogeneity and horizontal pleiotropy, thereby demonstrating the robustness of the findings. Subsequent bioinformatics analysis employed machine learning algorithms to identify potential OP-related diagnostic biomarkers in IA, with diagnostic performance assessed using receiver operating characteristic curves. Furthermore, immune infiltration analysis was performed to preliminarily characterize the immune microenvironment features in IA patients.</p><p><strong>Results: </strong>IVW results suggested a potential association between low bone density and an increased risk of IA, although this finding did not remain significant after correction for multiple testing. Reverse Mendelian randomization (MR) analysis revealed that the genetic susceptibility to IA did not have a significant impact on the relative risk of bone density. Furthermore, our study identified 5 potential OP-related biomarkers in IA, which showed valuable diagnostic performance. Immune cell infiltration analysis suggested that the formation of IA may be related to immune responses induced by CD8 T cells, macrophages, and mast cells.</p><p><strong>Conclusion: </strong>These findings provide valuable insights into the relationship between OP and IA, offering new perspectives for the diagnosis and treatment of IA.</p>","PeriodicalId":15116,"journal":{"name":"Journal of Bone and Mineral Metabolism","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2026-08-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148793504","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A DXA-based profile of body composition in celiac patients: a cross-sectional retrospective study.","authors":"Mirjana Di Paolo, Mirena Buttazzoni, Marcelina Carretero, María Laura Gonzalez, Mariano Martín Marcolongo, María Dolores Matoso","doi":"10.1007/s00774-026-01742-y","DOIUrl":"https://doi.org/10.1007/s00774-026-01742-y","url":null,"abstract":"<p><strong>Introduction: </strong>Celiac disease (CD) is frequently associated with bone and mineral metabolism alterations. As the clinical phenotype shifts from malabsorptive to normal-weight or obese, precise evaluation of body composition is essential to assess metabolic and sarcopenia risks. This study utilized Dual-Energy X-ray Absorptiometry (DXA) to characterize body composition and Bone Mineral Density (BMD) in a contemporary adult CD cohort.</p><p><strong>Materials and methods: </strong>We conducted a single-center, retrospective observational study of 77 CD patients (73% female) under 52 years of age; menopausal women were excluded. DXA was used to measure Appendicular Lean Mass Index (ALMI) Z-score, Bone Mineral Content (BMC) Z-score, and Total BMD Z-score.</p><p><strong>Results: </strong>Soft tissue parameters, including ALMI and fat mass Z-scores, clustered around zero for both sexes, indicating a composition profile comparable to the NHANES reference population. Conversely, bone health was consistently compromised, especially in women. Female patients exhibited negative Total BMD Z-scores across all age groups, with the lowest mean in the 40-44 age cohort (- 1.0 ± 1.0). BMC Z-scores were also predominantly negative (e.g., - 1.1 ± 1.5 in the 40-44 group). Male patients showed heterogeneous BMD Z-scores, ranging from - 1.04 ± 1.0 (25-29 years) to positive values in older subgroups.</p><p><strong>Conclusion: </strong>In this cohort, the modern CD phenotype presents a preserved soft tissue composition. However, low BMD remains a persistent finding, particularly in premenopausal women. These results underscore the necessity of systematic DXA screening in adult CD patients, regardless of their body mass index or clinical presentation.</p>","PeriodicalId":15116,"journal":{"name":"Journal of Bone and Mineral Metabolism","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2026-08-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148793516","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}