Journal of Bone and Mineral Metabolism最新文献

{"title":"Misaligned cardiovascular safety warnings for romosozumab in Japan.","authors":"Hiroshi Kawaguchi","doi":"10.1007/s00774-025-01593-z","DOIUrl":"10.1007/s00774-025-01593-z","url":null,"abstract":"","PeriodicalId":15116,"journal":{"name":"Journal of Bone and Mineral Metabolism","volume":" ","pages":"315-316"},"PeriodicalIF":2.4,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143492080","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Thoracolumbar kyphosis prognoses poor results after proximal femoral fracture: a 3-year multicenter prospective cohort study.","authors":"Yutaro Sugawara, Hotaka Ishizu, Kosuke Arita, Tetsuro Oue, Komei Sato, Renya Takahashi, Kenichi Kusunoki, Shun Shimodan, Tsuyoshi Asano, Norimasa Iwasaki, Tomohiro Shimizu","doi":"10.1007/s00774-024-01576-6","DOIUrl":"10.1007/s00774-024-01576-6","url":null,"abstract":"<p><strong>Introduction: </strong>Proximal femoral fractures are critically associated with increased risk of mortality and secondary fractures. Identifying prognosis predictors related to sagittal imbalance that are known to have negative impact on fracture risk and mortality is crucial. This study aimed to explore the relationship between various sagittal imbalance parameters and the prognosis of proximal femoral fractures to identify the most important prognostic indicators.</p><p><strong>Materials and methods: </strong>This multi-center prospective cohort study included patients with proximal femoral fractures treated surgically from April 2020 to March 2021. Spinal standing radiographs were obtained to measure various sagittal spine parameters. Postoperative follow-ups were conducted at 6, 12, 18, 24, and 36 months to assess mortality and secondary fracture rates and examine the predictors and their effects.</p><p><strong>Results: </strong>Among the 137 patients who underwent spinal standing radiographs, 22 died and 23 developed secondary fractures. Multivariate analyses identified the number of previous vertebral fractures and thoracolumbar kyphosis (TLK) as significant risk factors for mortality and secondary fractures. Survival analysis revealed that patients with TLK < 20° had significantly higher survival rates than those with TLK ≥ 20° (P = 0.002 and P < 0.001 for mortality and secondary fractures, respectively). In addition, serum albumin was associated with mortality, and the intake of sleeping pills and antidepressants was associated with secondary fractures.</p><p><strong>Conclusion: </strong>TLK after surgery and the number of previous vertebral fractures affected both mortality and secondary fractures. When each risk factor, such as low serum albumin levels, intake of sleeping pills and antidepressants, was also considered, it was found that comprehensive postoperative care is essential.</p>","PeriodicalId":15116,"journal":{"name":"Journal of Bone and Mineral Metabolism","volume":" ","pages":"237-248"},"PeriodicalIF":2.4,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142949377","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of mechanotransduction on gene expression changes in periodontal ligament during orthodontic tooth movement.","authors":"Suzu Chida, Tomoki Chiba, Yutaro Uchida, Takahide Matsushima, Ryota Kurimoto, Takayuki Miyazaki, Lisa Yagasaki, Satoshi Nakamura, Emiko Mihara, Junichi Takagi, Keiji Moriyama, Hiroshi Asahara","doi":"10.1007/s00774-025-01581-3","DOIUrl":"10.1007/s00774-025-01581-3","url":null,"abstract":"<p><strong>Introduction: </strong>The periodontal ligament (PDL) is a structure between the alveolar bone and cementum, essential for tooth stability and composed of diverse cell types. Mohawk homeobox (Mkx) is a master transcription factor that regulates tendon and ligament homeostasis. However, the specific cell populations expressing Mkx and its role in mechanotransduction during orthodontic tooth movement (OTM) remain unclear.</p><p><strong>Materials and methods: </strong>We conducted single-cell RNA sequencing on wild-type rat PDL at 0 day, 1 week, and 2 weeks of post-OTM using coil springs to elucidate Mkx's function and the changes in cell populations under continuous mechanical stimulation. In addition, RT-qPCR was performed to assess the relationship between tenogenic gene expression and Mkx expression in human PDL cells.</p><p><strong>Results: </strong>The rat PDL was identified to consist of 14 clusters, with Mkx and Scleraxis (Scx) expressed in distinct cell populations. Collagen and ECM production increased throughout the OTM period, while the sterile inflammatory response was initially heightened and later diminished, indicating that bone remodeling occurs later in the inflammatory response. Overexpression of MKX in human PDL cells enhanced COL1A1 and DECORIN expression.</p><p><strong>Conclusion: </strong>Mechanical stimulation of the PDL appears to trigger an aseptic inflammatory response that disrupts PDL homeostasis and promotes bone remodeling. Mkx may exert a protective effect on the PDL during mechanical stimulation.</p>","PeriodicalId":15116,"journal":{"name":"Journal of Bone and Mineral Metabolism","volume":" ","pages":"216-229"},"PeriodicalIF":2.4,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143073203","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sirt1 overexpression inhibits chondrocyte ferroptosis via Ftl deacetylation to suppress the development of osteoarthritis.","authors":"Xiaolong Xiong, Hui Huang, Ning Wang, Kai Zhou, Xinghui Song","doi":"10.1007/s00774-024-01574-8","DOIUrl":"10.1007/s00774-024-01574-8","url":null,"abstract":"<p><strong>Introduction: </strong>Osteoarthritis (OA) is a chronic degenerative joint disorder characterized by an imbalance in chondrocyte metabolism. Ferroptosis has been implicated in the pathogenesis of OA. The role of Sirt1, a deacetylase, in mediating deacetylation during ferroptosis in OA chondrocytes remains underexplored. This study aimed to elucidate the mechanisms by which Sirt1 influences chondrocyte ferroptosis in the development of OA.</p><p><strong>Materials and methods: </strong>In vitro and in vivo models of OA were established using IL-1β-induced mouse chondrocytes and a destabilization of the medial meniscus (DMM) mouse model, respectively. Ferroptosis was evaluated through measurements of cell viability, lactate dehydrogenase (LDH) release, intracellular levels of Fe2+, glutathione (GSH), malondialdehyde (MDA), lipid reactive oxygen species (ROS), propidium iodide staining, and Western blot analysis. The underlying mechanisms were further investigated using quantitative real-time polymerase chain reaction, Western blotting, immunoprecipitation (IP), co-immunoprecipitation (Co-IP), and glutathione-S-transferase pulldown assays. In vivo validation was performed via Safranin O staining.</p><p><strong>Results: </strong>IL-1β induced ferroptosis and increased histone acetylation, effects that were partially reversed by Sirt1 overexpression. Mechanistically, Sirt1 overexpression upregulated ferritin light polypeptide (Ftl) expression by deacetylating Ftl at the K181 residue. Ftl knockdown inhibited the ferroptosis-enhancing effect of Sirt1 overexpression in chondrocytes. In vivo studies showed that Sirt1 overexpression mitigated the progression of OA and reduced ferroptosis in the DMM-induced OA mouse model.</p><p><strong>Conclusion: </strong>Our findings confirm that Sirt1 overexpression promotes Ftl expression through deacetylation at the K181 site, thereby suppressing chondrocyte ferroptosis and attenuating the progression of OA. These results suggest a potential therapeutic target for OA treatment.</p>","PeriodicalId":15116,"journal":{"name":"Journal of Bone and Mineral Metabolism","volume":" ","pages":"203-215"},"PeriodicalIF":2.4,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142949376","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Romosozumab and cardiovascular safety in Japan.","authors":"Yasuhiro Takeuchi","doi":"10.1007/s00774-025-01596-w","DOIUrl":"10.1007/s00774-025-01596-w","url":null,"abstract":"","PeriodicalId":15116,"journal":{"name":"Journal of Bone and Mineral Metabolism","volume":" ","pages":"317-318"},"PeriodicalIF":2.4,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12089211/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143585821","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Methodology for the international working group clinical practice guidelines on X-linked hypophosphatemia in children and adults.","authors":"Dalal S Ali, Aliya A Khan, Reza D Mirza, Natasha M Appelman-Dijkstra, Maria Luisa Brandi, Thomas O Carpenter, Catherine Chaussain, Erik A Imel, Suzanne M Jan de Beur, Pablo Florenzano, Archibald Morrison, Hajar Abu Alrob, R Todd Alexander, Farah Alsarraf, Signe Sparre Beck-Nielsen, Martin Biosse-Duplan, Martine Cohen-Solal, Rachel K Crowley, Karel Dandurand, Guido Filler, Seiji Fukumoto, Claudia Gagnon, Paul Goodyer, Corinna Grasemann, Chelsey Grimbly, Salma Hussein, Muhammad K Javaid, Sarah Khan, Aneal Khan, Anna Lehman, Willem F Lems, E Michael Lewiecki, Ciara McDonnell, Emmett Morgante, Anthony A Portale, Yumie Rhee, Heide Siggelkow, Laura Tosi, Leanne M Ward, Gordon Guyatt","doi":"10.1007/s00774-025-01585-z","DOIUrl":"10.1007/s00774-025-01585-z","url":null,"abstract":"<p><p>The guideline panel, comprising international experts in X-linked hypophosphatemia (XLH), patient partners from the XLH patient population, and guideline methodologists, held 18 teleconferences between January 2023 and July 2024 to develop comprehensive guidelines for the diagnosis and management of XLH in children and adults. For a subset of our questions, we utilized the Grading of Recommendations, Assessment, Development, and Evaluation (GRADE) methodology, assessed the certainty of evidence and formulated GRADEd recommendations. For these questions, the panelists and methodologists collaboratively framed PICO (Population, Intervention, Control, and Outcomes) questions and conducted four systematic reviews assessing the impact of medical therapy-using either burosumab or phosphate and active vitamin D-on patient-important outcomes in the XLH population as well as the impact of medical intervention compared to no treatment. We assessed the risk of bias and transparently generated summary of findings tables using MAGICApp. The panel developed three GRADEd treatment recommendations for adults and two for children. Each GRADEd recommendation was linked to an underlying body of evidence, reflecting judgments on the certainty of evidence, recommendation strength, values, preferences, and considerations of costs, feasibility, acceptability, and equity. Due to the paucity of evidence, the panel developed very low-quality GRADEd recommendations on monitoring patients with XLH based on an expert clinical practice survey. Using a rigorous narrative literature review, the panel developed non-GRADEd recommendations including guidance for pregnant women, patients with dental complications, and other areas where evidence is limited. This article summarizes the methodology utilized for the development of both GRADEd and non-GRADEd recommendations for patients with XLH.</p>","PeriodicalId":15116,"journal":{"name":"Journal of Bone and Mineral Metabolism","volume":" ","pages":"193-202"},"PeriodicalIF":2.4,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143676966","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Randomized crossover comparison of two teriparatide self-injection regimens for primary osteoporosis: Interim report (end of 52-week treatment) of the Japanese Osteoporosis Intervention Trial 06 (JOINT-06).","authors":"Satoshi Soen, Yukari Uemura, Shiro Tanaka, Yasuhiro Takeuchi, Naoto Endo, Junichi Takada, Satoshi Ikeda, Jun Iwamoto, Nobukazu Okimoto, Sakae Tanaka","doi":"10.1007/s00774-025-01586-y","DOIUrl":"10.1007/s00774-025-01586-y","url":null,"abstract":"<p><strong>Introduction: </strong>Patient satisfaction with two teriparatide (TPTD) self-injection regimens [once-daily (1/D)-TPTD and twice-weekly (2/W)-TPTD] was compared in a randomized crossover study involving patients with osteoporosis at high fracture risk.</p><p><strong>Materials and methods: </strong>Questionnaires evaluated overall satisfaction, satisfaction with treatment effectiveness, satisfaction with utility of the self-injection device, and preference for a particular injection regimen after crossover. Quality of life (QOL), visual analogue scale pain scores, and bone mineral density (BMD) were also analyzed. Safety was evaluated based on the incidence and severity of adverse events (AEs).</p><p><strong>Results: </strong>The 1/D-TPTD and 2/W-TPTD groups comprised 180 (mean age: 75.9 ± 7.3 years) and 178 (75.4 ± 6.9 years) patients, respectively. After 26 weeks of treatment, the injection regimens were switched and treatment continued for another 26 weeks. Significantly higher persistence was observed in the 1/D-TPTD to 2/W-TPTD group (p = 0.032). No significant between-group differences in overall satisfaction scores or satisfaction with treatment were observed. Satisfaction with the utility of the injection device was significantly higher with the 2/W-TPTD regimen (p < 0.05); this regimen was preferred by 69.4% of patients after crossover (p < 0.001). A significant increase in BMD from baseline was observed at the lumbar vertebrae in both groups and at the hip area in the 1/D-TPTD to 2/W-TPTD group at 52 weeks (p < 0.05). Significant improvement in the QOL score was observed in both groups (p < 0.05). No serious AEs were reported.</p><p><strong>Conclusion: </strong>Continuation of this study will further clarify patient satisfaction, treatment effects, and tolerability.</p>","PeriodicalId":15116,"journal":{"name":"Journal of Bone and Mineral Metabolism","volume":" ","pages":"284-292"},"PeriodicalIF":2.4,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12089251/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143449116","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Vitamin D supplementation improves genu varum in toddlers: two-center pilot study.","authors":"Yuko Sakamoto, Makoto Kamegaya, Takashi Saisu, Yohei Tomaru, Akifumi Tokita, Sung-Gon Kim, Muneaki Ishijima","doi":"10.1007/s00774-025-01583-1","DOIUrl":"10.1007/s00774-025-01583-1","url":null,"abstract":"<p><strong>Introduction: </strong>The natural alignment of the lower extremities shifts rapidly from genu varum to neutral during early childhood. However, persistent or worsening genu varum, termed physiological genu varum, may be associated with vitamin D (VitD) deficiency. This study aimed to evaluate the effect of low-dose VitD supplementation on genu varum improvement in toddlers, given the prevalence of VitD deficiency and lack of supplementation practices in Japan.</p><p><strong>Materials and methods: </strong>This retrospective study included 90 toddlers aged 10-30 months with genu varum (tibiofemoral angle > 5°). The supplement group (n = 30) received 400 IU/day of VitD and moderate sun exposure, while the non-supplement group (n = 60) received only follow-up care. Radiographic parameters, including tibiofemoral angle (TFA), metaphyseal-diaphyseal angle (MDA), and metaphyseal-metaphyseal angle (MMA), were measured at baseline, 6 months, and 12 months. Seasonal variations in ultraviolet (UV) exposure were also considered. Statistical analyses used the Kruskal-Wallis and Mann-Whitney tests.</p><p><strong>Results: </strong>Both groups showed significant radiographic improvements over 12 months. However, the supplement group demonstrated greater reductions in TFA (p = 0.04), MDA (p < 0.01), and MMA (p < 0.01) at both 6 and 12 months. Seasonal UV variations influenced outcomes, with moderate-high UV seasons showing more pronounced improvements. Despite a low dose of VitD, the supplement group experienced significantly enhanced alignment compared to the non-supplement group.</p><p><strong>Conclusion: </strong>Low-dose VitD supplementation may accelerate the natural improvement of genu varum, particularly in populations with prevalent VitD deficiency. Genu varum may serve as a visible indicator of VitD deficiency. A prospective randomized-controlled trial is warranted to validate these findings.</p>","PeriodicalId":15116,"journal":{"name":"Journal of Bone and Mineral Metabolism","volume":" ","pages":"265-273"},"PeriodicalIF":2.4,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143364779","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Validation of an osteoporosis self-assessment tool for Vietnamese postmenopausal women and men over 50 years.","authors":"Anh The Nguyen, Thuy Thi Bui, Nguyet Thi Minh Tran, Oanh Ngoc Nguyen, Huyen Thi Thanh Pham, Phuong Thi Tran, Hue Thi Hoang, Hang Thi Diem, Duong Thanh Tran","doi":"10.1007/s00774-025-01582-2","DOIUrl":"10.1007/s00774-025-01582-2","url":null,"abstract":"<p><strong>Introduction: </strong>The aim of this study was to validate the effectiveness of the osteoporosis self-assessment tool for Asians (OSTA) in the screening and diagnosis of osteoporosis in men aged over 50 years and postmenopausal women in the northern Vietnam population.</p><p><strong>Materials and methods: </strong>This study included 8077 participants (7044 postmenopausal women and 1033 men aged over 50) who attended health examinations at the National Institute of Nutrition, Vietnam, from 2010-2019. Osteoporosis is defined by a T-score ≤ -2.5 at the femoral neck, total hip, or L1-L4. OSTA scores were assessed for identifying osteoporosis via receiver operating characteristic (ROC) curves. The optimal cut-off points, sensitivity, specificity, and areas under the ROC curves (AUCs) were determined.</p><p><strong>Results: </strong>The study showed that the prevalence of osteoporosis was 13.4% in men and 25.5% in women. In women, a higher BMI and OSTA scores decreased the OR of osteoporosis (all p-values < 0.001). In men, a higher BMI decreased the OR of osteoporosis (p-value < 0.001). The results showed that the OSTA value was -1 which had a sensitivity of over 70% in both men and women. The OSTA value was -4 which had a sensitivity of over 90% and specificity of over 80% in both men and women. The optimal OSTA value was -3 which had a sensitivity of over 90% and a specificity of over 80% in both men and women.</p><p><strong>Conclusions: </strong>The OSTA might be a simple tool for the screening and diagnosis of osteoporosis in Vietnamese postmenopausal women and men aged over 50 years.</p>","PeriodicalId":15116,"journal":{"name":"Journal of Bone and Mineral Metabolism","volume":" ","pages":"274-283"},"PeriodicalIF":2.4,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143370682","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Osteoporosis and stroke: a bidirectional mendelian randomization study.","authors":"Miao He, Haochuan Yong, Zhidong Cao, Jie Li","doi":"10.1007/s00774-025-01579-x","DOIUrl":"10.1007/s00774-025-01579-x","url":null,"abstract":"<p><strong>Introduction: </strong>Numerous observational studies have identified a link between osteoporosis and stroke. However, the causal genetic relationship between these conditions remains unclear. This study employs a two-sample bidirectional Mendelian randomization (MR) approach to ascertain the causal relationship between osteoporosis and stroke.</p><p><strong>Materials and methods: </strong>We conducted a two-sample Mendelian randomization (MR) study to investigate the potential causal relationship between osteoporosis and stroke, including its subtypes. Genetic data for osteoporosis and stroke, along with their subtypes, were sourced from published genome-wide association studies (GWAS). Single nucleotide polymorphisms (SNPs) demonstrating genome-wide significance (p < 5 × 10^ - 8) and independence (r^2 < 0.001) were selected for further analysis, provided they had an F-statistic ≥ 10. The inverse-variance weighted (IVW) method was employed to evaluate causality, with results reported as odds ratios (ORs). Heterogeneity was assessed using Cochran's Q test, while pleiotropy was tested using the MR-Egger intercept test. A leave-one-out sensitivity analysis was performed to ensure the robustness of the results.</p><p><strong>Results: </strong>Employing the IVW method, MR Egger method, and median-weighted method, we found no significant bidirectional causal relationship between osteoporosis and stroke or its subtypes, irrespective of the inclusion of potential pleiotropic SNPs. Sensitivity analyses affirmed the reliability and stability of these findings.</p><p><strong>Conclusion: </strong>Our study findings indicate that there is no direct causal relationship between osteoporosis and stroke or its subtypes in either direction. Based on our results, although no direct link was found, secondary effects do exist.</p>","PeriodicalId":15116,"journal":{"name":"Journal of Bone and Mineral Metabolism","volume":" ","pages":"256-264"},"PeriodicalIF":2.4,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12089162/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142949375","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}