Journal of Bone and Mineral Metabolism最新文献_第3页

Gut microbiota transmits osteoimmune dysregulation and exacerbates trabecular bone loss in tristetraprolin-deficient mice. 肠道微生物群传递骨免疫失调，并加剧三聚丙氨酸缺乏小鼠的小梁骨丢失。

IF 2.9 3区医学

Journal of Bone and Mineral Metabolism Pub Date : 2026-08-17 DOI: 10.1007/s00774-026-01753-9

Kyu Hwan Kwack, Jiho Sohn, Lixia Zhang, Lu Li, Reegan Mullaney, Yukitomo Arao, Perry J Blackshear, Keith L Kirkwood

{"title":"Gut microbiota transmits osteoimmune dysregulation and exacerbates trabecular bone loss in tristetraprolin-deficient mice.","authors":"Kyu Hwan Kwack, Jiho Sohn, Lixia Zhang, Lu Li, Reegan Mullaney, Yukitomo Arao, Perry J Blackshear, Keith L Kirkwood","doi":"10.1007/s00774-026-01753-9","DOIUrl":"https://doi.org/10.1007/s00774-026-01753-9","url":null,"abstract":"Introduction: Tristetraprolin (TTP) is an RNA-binding protein essential for controlling cytokine production, and its deficiency leads to profound skeletal deterioration. Although TTP deficiency is associated with systemic inflammation and microbial dysbiosis, the contribution of the gut microbiota to bone pathology remains poorly defined.Materials and methods: We investigated whether the microbiome causally modulates osteoimmune mechanisms and bone microarchitecture in TTP-deficient mice. To isolate the effects of the microbiome, we utilized specific pathogen-free (SPF) and germ-free (GF) co-housing mouse models.Results: Microbial transfer bidirectionally regulated systemic inflammation and the expansion of monocytic myeloid-derived suppressor cells (M-MDSCs), a population with potent osteoclastogenic capacity. Importantly, microbiota transfer was sufficient to induce osteoclast activation and a selective deterioration of trabecular bone microarchitecture in otherwise healthy mice, without affecting overall bone mass. Crucially, the transmission of these osteoimmune and skeletal phenotypes was microbiota-dependent; while a baseline genetic bone deficit persisted in GF TTP-deficient mice, the co-housing-induced M-MDSC expansion and trabecular bone alterations were not observed under GF conditions.Conclusion: Our findings identify a microbiota-dependent osteoimmune axis that amplifies inflammatory bone loss in TTP deficiency. This work establishes the gut microbiome as a mechanistic modifier of bone quality in genetically driven inflammatory disease and highlights microbial targeting as a potential therapeutic strategy for inflammatory bone loss.","PeriodicalId":15116,"journal":{"name":"Journal of Bone and Mineral Metabolism","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2026-08-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148793482","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Assessment of bone involvement by DXA and HR-pQCT in patients with X-linked hypophosphatemia. 通过DXA和HR-pQCT评估x连锁低磷血症患者的骨受累情况。

IF 2.9 3区医学

Journal of Bone and Mineral Metabolism Pub Date : 2026-08-11 DOI: 10.1007/s00774-026-01748-6

Iara Marcelino Sant Ana, Maria Caroline Alves Coelho, Joyce Cantoni, Leandro Kasuki, Maria Lucia Fleiuss Farias, Miguel Madeira

{"title":"Assessment of bone involvement by DXA and HR-pQCT in patients with X-linked hypophosphatemia.","authors":"Iara Marcelino Sant Ana, Maria Caroline Alves Coelho, Joyce Cantoni, Leandro Kasuki, Maria Lucia Fleiuss Farias, Miguel Madeira","doi":"10.1007/s00774-026-01748-6","DOIUrl":"https://doi.org/10.1007/s00774-026-01748-6","url":null,"abstract":"Introduction: X-linked hypophosphatemic rickets (XLH) is a rare disease and its natural history affects the quality of life of patients, as it leads to bone deformities and architectural and qualitative changes in the bone.Materials and methods: Sixteen XLH patients were selected from referral hospitals in Rio de Janeiro (12 women and four men) and compared to 16 healthy age- and sex-matched control individuals. All XLH were receiving calcitriol and oral phosphate supplements. Bone assessment was performed by high-resolution peripheral quantitative computed tomography (HR-pQCT) and dual-energy X-ray absorptiometry (DXA).Results: XLH patients showed higher lumbar spine BMD Z-score, but lower 33% distal radius BMD and Z-score values as compared to control group. Low BMD for age (Z-score ≤ -2.0 SD) was only detected in the XLH group: specifically in 3 of the 5 postmenopausal women, 3 of the 7 premenopausal women, and 2 of the 4 men. HR-pQCT evaluation showed lower total vBMD at both peripheral sites and impaired trabecular parameters, particularly at the distal tibia, after correction for multiple comparisons.Conclusion: Our study sheds light on the involvement of both trabecular and cortical compartments in the XLH group, despite conventional treatment. We also emphasize the limitation of DXA in assessing central sites in the XLH group. The 33% radius may represent a useful complementary skeletal site for DXA assessment, particularly when HR-pQCT is not available.","PeriodicalId":15116,"journal":{"name":"Journal of Bone and Mineral Metabolism","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2026-08-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148706637","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Evaluating Haversian canal-to-osteon ratios for reconstructing bone remodelling activity: balancing precision and efficiency in data collection. 评估重建骨重塑活动的哈弗森管-骨比率：平衡数据收集的精度和效率。

IF 2.9 3区医学

Journal of Bone and Mineral Metabolism Pub Date : 2026-08-10 DOI: 10.1007/s00774-026-01747-7

Karen M Cooke, Isabella Pearce, R Claire Aland, Julien Louys, Patrick Mahoney, Justyna J Miszkiewicz

{"title":"Evaluating Haversian canal-to-osteon ratios for reconstructing bone remodelling activity: balancing precision and efficiency in data collection.","authors":"Karen M Cooke, Isabella Pearce, R Claire Aland, Julien Louys, Patrick Mahoney, Justyna J Miszkiewicz","doi":"10.1007/s00774-026-01747-7","DOIUrl":"https://doi.org/10.1007/s00774-026-01747-7","url":null,"abstract":"Introduction: In cortical bone histology, the ratio of Haversian canal and secondary osteon areas reflects bone resorption and formation during metabolic events executed by Basic Multicellular Units (BMUs). Area data can be pooled where they are collected independently, and the ratio calculated from the mean of each measure. They can also be paired, where they are measured from the same secondary osteon at once and the mean of individual ratios is calculated. We evaluate the impact of pooling and pairing on the resulting ratio values and their interpretation of bone remodelling.Materials and methods: Using both approaches, we calculated the area ratio of 551 Haversian canals and secondary osteons from measurements of existing midshaft femur histology slides. The sample represents n = 38 young and middle-aged females of different social backgrounds from a historical osteological collection. Univariate and bivariate statistics were used to compare and evaluate paired and pooled values and their differences.Results: The pooled method usually returned a lower canal-to-osteon value than paired data across the whole sample, ages, and social groups. These methods differed in the ratios they produced, independently of the number of measurements per sample.In conclusion: The pooling technique indicated the presence of thicker lamellar bone within secondary osteons, suggesting greater quantities of bone formed during BMU activity, than the paired technique results, which suggested less bone formed per BMU. While pooling offers efficiency in data collection and analysis, we show that paired data yield more biologically precise and analytically flexible results at an individual BMU level.","PeriodicalId":15116,"journal":{"name":"Journal of Bone and Mineral Metabolism","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2026-08-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148706674","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Response to: "Comment on "Trends in the incidence of secondary hip fractures and osteoporosis treatment in Japan (FY2012-FY2023)"". 对“日本继发性髋部骨折和骨质疏松症治疗趋势（2012- 2023财年）”的评论。

IF 2.9 3区医学

Journal of Bone and Mineral Metabolism Pub Date : 2026-08-07 DOI: 10.1007/s00774-026-01746-8

Shinichi Nakatoh

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Response to: "Comment on 'Identification of potential diagnostic and therapeutic apoptosis-related causal targets for osteoporosis: an integrated multi-omics analysis'". 对“鉴定骨质疏松症的潜在诊断和治疗细胞凋亡相关的因果靶点：综合多组学分析”的评论”的回应。

IF 2.9 3区医学

Journal of Bone and Mineral Metabolism Pub Date : 2026-08-07 DOI: 10.1007/s00774-026-01744-w

Yixi Wang, Lintao Xia, Yang Xiao, Mingxing Wu, Rui Zhang, Paerhati Rexiti, Hui Zhang

引用次数: 0

Comment on "Trends in the incidence of secondary hip fractures and osteoporosis treatment in Japan (FY2012-FY2023)". 对“日本继发性髋部骨折和骨质疏松症治疗趋势（2012- 2023财年）”的评论。

IF 2.9 3区医学

Journal of Bone and Mineral Metabolism Pub Date : 2026-08-06 DOI: 10.1007/s00774-026-01745-9

Huzaifa Khurshid, Munir Ahmad

引用次数: 0

Comment on "Identification of potential diagnostic and therapeutic apoptosis-related casual targets for osteoporosis: an integrated multi-omics analysis". 对“骨质疏松症潜在的诊断和治疗凋亡相关的随机靶点的识别：一种综合的多组学分析”的评论。

IF 2.9 3区医学

Journal of Bone and Mineral Metabolism Pub Date : 2026-08-05 DOI: 10.1007/s00774-026-01743-x

Shumeng Huang, Diguang Wen

引用次数: 0

Author's response to the letter regarding 'Association of serum magnesium levels and calcimimetic use: fractures and cardiovascular events in Japanese haemodialysis patients'. 作者对“血清镁水平与钙化剂使用的关系：日本血液透析患者的骨折和心血管事件”信函的回应。

IF 2.9 3区医学

Journal of Bone and Mineral Metabolism Pub Date : 2026-07-20 DOI: 10.1007/s00774-026-01739-7

Tomohiro Saito, Masahide Mizobuchi, Kiryu Yoshida, Tadashi Kato, Kazuki Abe, Toshiaki Takezaki, Noriyuki Kato, Eisuke Inoue, Hiroaki Ogata, Fumihiko Koiwa, Hirokazu Honda

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Response to the Letter to the Editor, Commentary on "Incident subclinical vertebral fractures and health-related quality of life: JPOS cohort study". 对“亚临床椎体骨折与健康相关生活质量：JPOS队列研究”的评论致编辑信的回复。

IF 2.9 3区医学

Journal of Bone and Mineral Metabolism Pub Date : 2026-07-20 DOI: 10.1007/s00774-026-01741-z

Mayumi Uesaka, Masami Hamada, Takahiro Tachiki, Yuho Sato, Kouji Tsuda, Asako Kudo, Kuniyasu Kamiya, Nami Imai, Akemi Nitta, Miho Tanaka, Kumiko Ohara, Naoyuki Takashima, Jun Kitagawa, Katsuyasu Kouda, Akemi Morita, Kazuhiro Uenishi, Etsuko Kajita, Koji Tamakoshi, Sadanobu Kagamimori, Junko Tamaki, Masayuki Iki

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Toward skeletal phenotyping in magnesium-calcimimetic studies of hemodialysis. 血液透析中镁钙模拟研究的骨骼表型研究。

IF 2.9 3区医学

Journal of Bone and Mineral Metabolism Pub Date : 2026-07-18 DOI: 10.1007/s00774-026-01738-8

Kaiquan Zhang, Meng Zhao, Dongdong Li

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