Journal of Bone and Mineral Metabolism最新文献

{"title":"Commentary on \"The effects of sequential therapy using anti-resorptive agents after administering once-weekly teriparatide or twice-weekly teriparatide\".","authors":"Fei Ji, Yizhou Chen","doi":"10.1007/s00774-026-01716-0","DOIUrl":"10.1007/s00774-026-01716-0","url":null,"abstract":"","PeriodicalId":15116,"journal":{"name":"Journal of Bone and Mineral Metabolism","volume":" ","pages":"562-563"},"PeriodicalIF":2.9,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147493708","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A comparative analysis of osteoporosis, nephrolithiasis, and metabolic/cardiovascular comorbidities in normocalcemic and mild primary hyperparathyroidism.","authors":"Mazhar Müslüm Tuna, İsmail Engin, Özden Uzun, Sevde Nur Fırat, Özge Kimyon, Elif Güneş, Kadircan Karatoprak, Ümit Nur Özbay, Ziynet Alphan Üç, Ali Yeşiltepe, Şevkican Güneş, Sayid Shafi Zuhur, Hüseyin Yağcı, Evin Bozkur, Özen Öz Gül, Ayten Oğuz, Cevdet Duran, Barış Güven Cansu, Nurdan Gül","doi":"10.1007/s00774-026-01732-0","DOIUrl":"10.1007/s00774-026-01732-0","url":null,"abstract":"<p><strong>Introduction: </strong>Normocalcemic primary hyperparathyroidism (NPHPT) is thought to be an early form of hypercalcemic primary hyperparathyroidism (PHPT). However, some studies have shown that the adverse effects on bone and kidney health are similar in both conditions.</p><p><strong>Materials and methods: </strong>This is a nationwide, multicentre, retrospective study. Data from centres, including 404 patients with NPHPT and 723 patients with mild PHPT from different regions of Turkey, were included in this study. All laboratory parameters, dual-energy X-ray absorptiometry, and renal ultrasounds were performed locally at each centre. The prevalence of adverse bone and kidney outcomes and metabolic and cardiovascular comorbidities were the main outcome measures.</p><p><strong>Results: </strong>Patients with NPHPT had lower calcium and PTH levels. Skeletal outcomes revealed 29% osteoporosis and 42% osteopenia, while the prevalence of nephrolithiasis was 12.4%, which is similar to that observed in patients with mild PHPT. Hypertension was more prevalent in patients with mild PHPT than in those with NPHPT (44.4% vs. 34.9%, p = 0.002), as was diabetes mellitus (27.9% vs. 13.2%, p < 0.001). The prevalence of cardiovascular disease was similar (11.5% vs. 9.5%, p = 0.306).</p><p><strong>Conclusion: </strong>Patients with NPHPT experience significant skeletal complications and nephrolithiasis but have lower rates of hypertension and diabetes.</p>","PeriodicalId":15116,"journal":{"name":"Journal of Bone and Mineral Metabolism","volume":" ","pages":"536-543"},"PeriodicalIF":2.9,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147863914","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Towards efficient osteoporosis screening: a simple and practical approach using OSTA and FRAX risk factors.","authors":"Chiaki Horii, Sakae Tanaka, Toshiko Iidaka, Saeko Fujiwara, Masayuki Iki, Yasushi Oshima, Shigeyuki Muraki, Hiroyuki Oka, Hiroshi Kawaguchi, Kozo Nakamura, Toru Akune, Noriko Yoshimura","doi":"10.1007/s00774-026-01729-9","DOIUrl":"10.1007/s00774-026-01729-9","url":null,"abstract":"<p><strong>Introduction: </strong>Osteoporosis is a major public health concern, particularly in the aging population, where fragility fractures significantly impact quality of life and mortality. Despite the importance of early detection, screening rates for osteoporosis in Japan remain low. The Osteoporosis Self-Assessment Tool for Asians (OSTA) and Fracture Risk Assessment Tool (FRAX) are noninvasive screening tools. This study aimed to develop an efficient method for screening osteopenia using these tools.</p><p><strong>Materials and methods: </strong>We analyzed data from 1060 Japanese women aged 40-74 years from the Research on Osteoarthritis/Osteoporosis Against Disability (ROAD) study. The OSTA and FRAX scores, as well as individual FRAX risk factors, were assessed for their ability to detect osteopenia. As FRAX score calculations are not publicly available, we evaluated the discriminative ability of the seven risk factors individually. Prior fragility fractures were deemed the most critical, and all 64 possible combinations of the remaining six risk factors were analyzed.</p><p><strong>Results: </strong>OSTA had the highest discriminative ability (AUC = 0.81), followed by FRAX-Hip (AUC = 0.79) and FRAX-Major (AUC = 0.77). The sensitivity and specificity of OSTA ≤ -1 were 83.7% and 62.6%, respectively. The most effective criterion was OSTA ≤ -1 or at least one FRAX risk factor, achieving a sensitivity of 90.4%, specificity of 47.2%, and positive predictive value of 63.3%.</p><p><strong>Conclusion: </strong>A simple, noninvasive osteopenia screening method combining OSTA ≤ -1 and FRAX risk factors identified at-risk individuals effectively. This approach could enhance osteoporosis screening in Japan and facilitate early intervention and fracture prevention.</p>","PeriodicalId":15116,"journal":{"name":"Journal of Bone and Mineral Metabolism","volume":" ","pages":"521-529"},"PeriodicalIF":2.9,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13469496/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147815229","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Editorial comment.","authors":"Toshio Matsumoto, Toshiyuki Yoneda","doi":"10.1007/s00774-026-01709-z","DOIUrl":"10.1007/s00774-026-01709-z","url":null,"abstract":"","PeriodicalId":15116,"journal":{"name":"Journal of Bone and Mineral Metabolism","volume":" ","pages":"556"},"PeriodicalIF":2.9,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147305547","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Identification of potential diagnostic and therapeutic apoptosis-related casual targets for osteoporosis: an integrated multi-omics analysis.","authors":"Yixi Wang, Lintao Xia, Yang Xiao, Mingxing Wu, Rui Zhang, Paerhati Rexiti, Hui Zhang","doi":"10.1007/s00774-026-01710-6","DOIUrl":"10.1007/s00774-026-01710-6","url":null,"abstract":"<p><strong>Introduction: </strong>Apoptosis plays a significant role in osteoporosis (OP), yet a causal relationship between apoptosis gene expressions and OP remains unexplored. This study applies an integrated multi-omics analysis to establish causality between them, offering clinical treatment and prediction insights.</p><p><strong>Materials and methods: </strong>Apoptosis-related genes are sourced from GeneCards, and 6 transcriptomic datasets from the cells in the circulation are obtained from GEO. Meta-analysis integrated differentially expressed apoptosis-related genes (DEGs) from the above 6 datasets. Causality between gene expressions, epigenetic changes, and OP is examined using OP genome-wide association study (GWAS), plasma expression quantitative trait loci (eQTL), and methylation quantitative trait loci (mQTL) data, while analysis of skeletal muscle eQTL and OP GWAS data is conducted. External validation is performed with the UK Biobank datasets.</p><p><strong>Results: </strong>Meta-analysis of 6 GEO datasets identified 384 DEGs, including 78 apoptosis-related genes. The three-step analysis indicates 8 candidate causal genes in blood, including MAP3K3, DPP8, RPL3, PPP2CA, CD86, LRRFIP1, TRAP1, and DUSP6, with LRRFIP1 influenced by four methylation sites. Analysis of skeletal muscle data reveals 4 causal genes, including SIPA1L3, PDLIM7, CTNNB1, and DPP8. Among apoptosis-related genes causally linked to OP in both circulation and skeletal muscle, LRRFIP1 was validated based on methylation-associated regulation and demonstrated consistent, reproducible expression patterns.</p><p><strong>Conclusions: </strong>This study uses a multi-omics strategy to clarify the roles of apoptosis-related gene expressions and their corresponding methylation in OP, providing targets and a basis for early diagnosis, personalized treatment, and monitoring of OP.</p>","PeriodicalId":15116,"journal":{"name":"Journal of Bone and Mineral Metabolism","volume":" ","pages":"469-481"},"PeriodicalIF":2.9,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147503929","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence and progression of hip osteoarthritis in individuals with diffuse idiopathic skeletal hyperostosis.","authors":"Masaya Kubota, Takayoshi Shimizu, Masaki Sakamoto, Masahiro Yakami, Takashi Sono, Ryusuke Nakamoto, Shuichi Matsuda, Bungo Otsuki","doi":"10.1007/s00774-026-01723-1","DOIUrl":"10.1007/s00774-026-01723-1","url":null,"abstract":"<p><strong>Introduction: </strong>Diffuse idiopathic skeletal hyperostosis (DISH) primarily affects the axial skeleton, but its association with hip osteoarthritis (OA) remains unclear. We investigated the prevalence and 5 year progression of hip OA in individuals with DISH and explored risk factors for progression.</p><p><strong>Materials and methods: </strong>This retrospective cohort study reviewed 694 asymptomatic individuals who underwent whole-body computed tomography (CT) for cancer screening (2016-2023) and had follow-up CT at ≥ 5 years. DISH was diagnosed using CT-based criteria. We identified 143 individuals with DISH and selected 143 age- and sex-matched controls without DISH (1:1). Hip OA was assessed using a CT-based composite score (0-14, bilateral). Radiographic hip OA was defined as a bilateral score ≥ 10, and progression as an increase of ≥ 2 points over 5 years. Multivariable regression analyses were performed to identify independent predictors of progression.</p><p><strong>Results: </strong>The DISH group had higher total hip OA scores and a higher prevalence of radiographic hip OA than controls at baseline and follow-up. However, OA progression rates did not differ significantly between groups. Among individuals with DISH, the number of ankylosed vertebral segments was independently associated with hip OA progression.</p><p><strong>Conclusion: </strong>Individuals with DISH show a higher prevalence of radiographic hip OA. Extensive spinal ankylosis may increase the risk of hip OA progression, supporting the need for longitudinal monitoring of hip joint health in DISH.</p>","PeriodicalId":15116,"journal":{"name":"Journal of Bone and Mineral Metabolism","volume":" ","pages":"482-488"},"PeriodicalIF":2.9,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147662507","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Giant cell tumor of bone inhibits osteoblastogenesis via WNT5B.","authors":"Masaki Shimada, Tomonori Tsuyama, Naoto Yoshimura, Makoto Tateyama, Hideto Matsunaga, Fuka Homma, Kasumi Dainobu, Xiao Tian, Shu Takata, Kosei Takata, Shuntaro Tanimura, Yuto Shibata, Kazuya Maeda, Junki Kawakami, Takahiro Arima, Tatsuki Karasugi, Takuya Tokunaga, Hiro Sato, Tetsuro Masuda, Satoshi Hisanaga, Yuki Kai, Soichiro Karata, Hikaru Goshogawa, Rui Tajiri, Hibiki Yamada, Yusuke Uehara, Takayuki Nakamura, Masaki Yugami, Kazuki Sugimoto, Ryuji Yonemitsu, Hironori Tanoue, Kazuya Yamagata, Takeshi Miyamoto","doi":"10.1007/s00774-026-01713-3","DOIUrl":"10.1007/s00774-026-01713-3","url":null,"abstract":"<p><strong>Introduction: </strong>Giant cell tumor of bone (GCTB) induces overproduction of bone-resorbing osteoclasts through receptor activator of nuclear factor kappa B ligand (RANKL), leading to bone resorption and destruction. Consequently, denosumab, a neutralizing antibody against RANKL (a cytokine essential for osteoclast induction), is used to treat patients with GCTB. However, the activity of bone formation in GCTB remains poorly understood. Here, we show that GCTB antagonizes bone formation by expressing WNT5B, which inhibits bone formation.</p><p><strong>Materials and methods: </strong>Co-culture of NCC-GCTB1-C1 (GCTB1s), a human GCTB cell line, with human adipose-derived stem cells (ADSCs) was performed with osteoblast induction medium. To identify the inhibitors of osteoblast differentiation, we reanalyzed the single-cell RNA sequencing data that was previously published. In addition, we performed spatial transcriptome analysis (Visium) against the section of paraffin block of GCTB. The targeted protein was knocked out using CRISPR/Cas9 and co-culture was performed.</p><p><strong>Results: </strong>Co-culture of GCTB1s with ADSCs significantly inhibited mineralization of ADSCs. Reanalysis of single-cell RNA sequencing data indicated that GCTB tumors express WNT5B, and we observed that GCTB1s express WNT5B. We then knocked out WNT5B in GCTB1s using CRISPR/Cas9 and co-cultured them with ADSCs and observed significant rescue of mineralization in ADSCs relative to ADSCs cultured with GCTB1s expressing WNT5B. We also show that ADSC supernatants induce mineralization of GCTB1s.</p><p><strong>Conclusion: </strong>These studies indicate that GCTB not only induces osteoclasts, but also possesses activity that inhibits bone formation.</p>","PeriodicalId":15116,"journal":{"name":"Journal of Bone and Mineral Metabolism","volume":" ","pages":"455-468"},"PeriodicalIF":2.9,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13469380/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147503873","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comment on: \"Trolox, r-irisin and resveratrol cocktail to counteract osteoblast metabolism alterations in osteoarthritis and osteoporosis\"-proposal to validate cocktail efficacy in female osteoblasts.","authors":"Jianying Chen, Xianda Zheng, Rongrong Chen","doi":"10.1007/s00774-025-01685-w","DOIUrl":"10.1007/s00774-025-01685-w","url":null,"abstract":"","PeriodicalId":15116,"journal":{"name":"Journal of Bone and Mineral Metabolism","volume":" ","pages":"548-549"},"PeriodicalIF":2.9,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146029651","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Critical insights on \"Low BMI and postoperative outcomes in elderly hip fracture patients: a Japanese nationwide database study\".","authors":"Tao Chen, Huasheng Su","doi":"10.1007/s00774-026-01692-5","DOIUrl":"10.1007/s00774-026-01692-5","url":null,"abstract":"","PeriodicalId":15116,"journal":{"name":"Journal of Bone and Mineral Metabolism","volume":" ","pages":"552-553"},"PeriodicalIF":2.9,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146029599","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of pregnancy and lactation-associated osteoporosis on children: analysis using linked mother and child data.","authors":"Kyoko Kasahara, Shunichiro Tsuji, Taku Kawasaki, Takashi Murakami","doi":"10.1007/s00774-026-01720-4","DOIUrl":"10.1007/s00774-026-01720-4","url":null,"abstract":"<p><strong>Introduction: </strong>The health status of children born to mothers with pregnancy and lactation-associated osteoporosis (PLO) and impaired bone homeostasis remains unknown. This study aimed to investigate the effects of maternal PLO on child health, the PLO-predisposing factors related to such effects, and the incidence of the condition.</p><p><strong>Materials and methods: </strong>From a claims dataset comprising 172,730 mothers linked with their 210,124 children, mothers who developed fragility fractures between 5 months before and 12 months after delivery, along with their children, were defined as the PLO group. Healthy controls were randomly selected by matching maternal age and child sex. Body mass index (BMI), drug use, and maternal and pediatric diseases were compared between the two groups.</p><p><strong>Results: </strong>Fifty-nine mothers and 65 children were included in the PLO group, and 11,556 mothers and 11,664 children served as the control group. The most common PLO fracture was a vertebral fracture, and delayed diagnosis was common. Maternal PLO had few adverse effects on child health. There were trends toward a higher frequency of birth asphyxia in singletons (P = 0.072) and low birth weight in twins (P = 0.070) in the case children, but with no significant differences. The incidence of PLO was estimated at 374 per million deliveries. Multiple delivery, maternal age ≥ 40 years, low BMI, heparin use, and ovulation disorder were identified as predisposing factors for PLO.</p><p><strong>Conclusion: </strong>There is little evidence that maternal PLO adversely affects child health. The predisposing factors for PLO suggest that caution is warranted regarding current advancements in reproductive technology.</p>","PeriodicalId":15116,"journal":{"name":"Journal of Bone and Mineral Metabolism","volume":" ","pages":"501-512"},"PeriodicalIF":2.9,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13468983/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147662463","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}