Journal of Bone and Mineral Metabolism最新文献_第7页

Revisiting inflammaging: a critical appraisal of its role in alveolar bone loss. 重访炎症：对其在牙槽骨丢失中的作用的关键评价。

IF 2.9 3区医学

Journal of Bone and Mineral Metabolism Pub Date : 2026-06-13 DOI: 10.1007/s00774-026-01733-z

Saqlain Shah, Sabtain Shah, Wardah Fazal, Muhammad Tahir, Tanzeela Gul

引用次数: 0

Correction: Time-dependent improvement of quality of life with teriparatide or alendronate therapy: a JOINT-05 sub-analysis. 更正：特立帕肽或阿仑膦酸钠治疗对生活质量的时间依赖性改善：一项JOINT-05亚分析。

IF 2.9 3区医学

Journal of Bone and Mineral Metabolism Pub Date : 2026-05-01 Epub Date: 2026-02-13 DOI: 10.1007/s00774-025-01637-4

Satoshi Mori, Shiro Tanaka, Tatsuhiko Kuroda, Hiroshi Hagino, Satoshi Soen

引用次数: 0

Alterations in bone-related hormones and genes expression in femoral bone of polycystic ovary syndrome rats. 多囊卵巢综合征大鼠股骨骨相关激素及基因表达的变化。

IF 2.9 3区医学

Journal of Bone and Mineral Metabolism Pub Date : 2026-05-01 Epub Date: 2026-02-15 DOI: 10.1007/s00774-025-01688-7

Mahsa Noroozzadeh, Mostafa Changaei, Mahbanoo Farhadi-Azar, Maryam Mousavi, Fahimeh Ramezani Tehrani

{"title":"Alterations in bone-related hormones and genes expression in femoral bone of polycystic ovary syndrome rats.","authors":"Mahsa Noroozzadeh, Mostafa Changaei, Mahbanoo Farhadi-Azar, Maryam Mousavi, Fahimeh Ramezani Tehrani","doi":"10.1007/s00774-025-01688-7","DOIUrl":"10.1007/s00774-025-01688-7","url":null,"abstract":"Introduction: Polycystic ovary syndrome (PCOS) has been associated with conflicting effects on bone mass, underscoring the need for deeper investigation into its impact on skeletal health. This study aimed to assess the expression of osteoporosis-related genes in femoral bone, alongside hormonal profile (bone-related hormones) alterations, across aging in a rat model of PCOS compared to controls.Materials and methods: Femoral bone RNA was extracted from rat model of PCOS and controls (n = 10-13 per group) at 3, 10, and 18 months of age. The expression of IL-11, DKK1, RANKL, AKT1, IGF-1, EphB4, STAT3, and CTNNB1 genes was quantified via Real-Time PCR. Concurrently, serum levels of Anti-Mullerian Hormone (AMH), calcitonin, cortisol, total testosterone (TT), and vitamin D3 were measured using ELISA.Results: A significantly elevated expression of IL-11, DKK1, RANKL, AKT1, and IGF-1 genes, accompanied by a decreased expression of EphB4 and STAT3 in the femoral bone of rat model of PCOS compared to controls, was observed. Additionally, rat model of PCOS exhibited higher serum levels of AMH, cortisol, and TT, whereas calcitonin and vitamin D3 levels were decreased.Conclusions: These molecular and hormonal alterations highlight a dysregulation in bone metabolism associated with PCOS and suggest that PCOS may represent a substantial risk factor for osteoporosis later in life. The employed rat model thus offers a valuable platform for elucidating the cellular and molecular mechanisms contributing to bone mass disorders in PCOS, facilitating the development of targeted therapeutic strategies.","PeriodicalId":15116,"journal":{"name":"Journal of Bone and Mineral Metabolism","volume":" ","pages":"288-301"},"PeriodicalIF":2.9,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146197574","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Critical Appraisal on "Bone mineral density after spinal cord injury: assessment of hip and knee measurements". 对“脊髓损伤后骨矿物质密度：髋关节和膝关节测量的评估”的批判性评价。

IF 2.9 3区医学

Journal of Bone and Mineral Metabolism Pub Date : 2026-05-01 Epub Date: 2025-12-07 DOI: 10.1007/s00774-025-01673-0

Richa Kothari, Rekha Pathak, Vandana Gupta

引用次数: 0

NEFL is associated with inhibition of odontoblastic process in odontohypophosphatasia. NEFL与牙齿低磷症中成牙细胞过程的抑制有关。

IF 2.9 3区医学

Journal of Bone and Mineral Metabolism Pub Date : 2026-05-01 Epub Date: 2026-03-14 DOI: 10.1007/s00774-026-01703-5

Akira Nozoe, Yasuhisa Ohata, Makoto Fujiwara, Kenichi Yamamoto, Toshihiko Nambara, Chiho Nakano, Kazuaki Miyagawa, Mikihiko Kogo, Takeshi Taketani, Takuo Kubota, Yasuji Kitabatake, Susumu Tanaka, Keiichi Ozono

{"title":"NEFL is associated with inhibition of odontoblastic process in odontohypophosphatasia.","authors":"Akira Nozoe, Yasuhisa Ohata, Makoto Fujiwara, Kenichi Yamamoto, Toshihiko Nambara, Chiho Nakano, Kazuaki Miyagawa, Mikihiko Kogo, Takeshi Taketani, Takuo Kubota, Yasuji Kitabatake, Susumu Tanaka, Keiichi Ozono","doi":"10.1007/s00774-026-01703-5","DOIUrl":"10.1007/s00774-026-01703-5","url":null,"abstract":"Introduction: Hypophosphatasia (HPP) is a rare bone disease caused by pathological variants of ALPL. While hypomineralization of dentin and odontoblast (OD) differentiation defects are known to occur in HPP, the underlying pathophysiology remains poorly understood.Materials and methods: We generated induced pluripotent stem cell (iPSC) lines from patients with perinatal severe HPP (Perinatal) and then isogenic (Rescued) and odontohypophosphatasia type (Odonto) lines using gene editing. These three HPP-iPSC lines were differentiated into OD-like cells via mesenchymal stem cells derived from neural crest cells. The characteristics of the OD-like cells were assessed.Results: Rescued-OD-like cells demonstrated mineralization ability, increased microtubule-associated protein tau (MAPT) expression, and unidirectional cell processes, while these characteristics were impaired in Perinatal- and Odonto-OD-like cells. These findings suggest that these features are associated with reduced ALP activity. Notably, neurofilament light chain (NEFL) expression was enhanced in Odonto-OD-like cells compared to Perinatal- and Rescued-OD-like cells. NEFL knockdown partially rescued cell process elongation in Odonto-OD-like cells without affecting alkaline phosphatase activity, while NEFL overexpression inhibited cell process elongation in Rescued-OD-like cells.Conclusions: Enhanced expression of NEFL in Odonto-OD-like cells negatively correlates with OD morphology and may be relevant to odontoblast morphological abnormalities associated with odontohypophosphatasia; however, generalization to other odonto-HPP genotypes requires additional patient-derived lines.","PeriodicalId":15116,"journal":{"name":"Journal of Bone and Mineral Metabolism","volume":" ","pages":"429-441"},"PeriodicalIF":2.9,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13246916/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147457668","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Fracture risk prediction, treatment thresholds, and the role of bone mineral density: a comparative analysis of FRAX and SHAFRE. 骨折风险预测、治疗阈值和骨矿物质密度的作用：FRAX和SHAFRE的比较分析。

IF 2.9 3区医学

Journal of Bone and Mineral Metabolism Pub Date : 2026-05-01 Epub Date: 2026-01-03 DOI: 10.1007/s00774-025-01684-x

Anna Nordström, Marcel Ballin, Viktor Ahlqvist, Peter Nordström

{"title":"Fracture risk prediction, treatment thresholds, and the role of bone mineral density: a comparative analysis of FRAX and SHAFRE.","authors":"Anna Nordström, Marcel Ballin, Viktor Ahlqvist, Peter Nordström","doi":"10.1007/s00774-025-01684-x","DOIUrl":"10.1007/s00774-025-01684-x","url":null,"abstract":"Introduction: Accurate prediction of fracture risk is important for treatment decisions, yet evaluations of commonly used thresholds are limited, and the added value of volumetric bone mineral density (vBMD) remains uncertain. We conducted the first head-to-head comparison of the SHAFRE and FRAX algorithms using identical predictor information.Materials and methods: We included 3525 community-dwelling Swedish men and women (mean age 71.4 years) who underwent a health examination with femoral neck areal BMD (aBMD) and radial vBMD. Incident fractures were retrieved from the National Patient Register. Model performance was evaluated using threshold-specific sensitivity and specificity.Results: Over a mean follow-up of 8.7 years, 559 participants sustained a fracture. SHAFRE predicted a mean 10-year fracture risk of 21.9% in those who fractured versus 15.6% in the remaining cohort (ROC-area: 68%, 95% CI: 66-71%). Corresponding FRAX values were 16.7% and 12.6% (ROC-area: 66%, 95% CI: 63-68%), and FRAX slightly underestimated fracture risk in this cohort. Adding radial vBMD on top of aBMD did not materially improve discrimination for SHAFRE (70%, 95% CI: 67-72%) or FRAX (68%, 95% CI: 65-70%). Threshold-specific analysis identified an optimal predicted risk threshold of 13-17%, consistently below the commonly recommended 20%.Conclusions: Predictive ability for major fractures remained modest for both algorithms and was not improved by adding vBMD. The estimated optimal threshold for treatment initiation was lower than the commonly recommended 20%. These findings reinforce that discrimination is substantially stronger for hip fracture than for major osteoporotic fractures.","PeriodicalId":15116,"journal":{"name":"Journal of Bone and Mineral Metabolism","volume":" ","pages":"325-335"},"PeriodicalIF":2.9,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13246558/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145896629","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Evocalcet improved the PTH-calcium setpoint and suppressed parathyroid proliferation in mice model of primary hyperparathyroidism. Evocalcet提高小鼠原发性甲状旁腺功能亢进模型pth -钙的设定值，抑制甲状旁腺增生。

IF 2.9 3区医学

Journal of Bone and Mineral Metabolism Pub Date : 2026-05-01 Epub Date: 2026-02-17 DOI: 10.1007/s00774-026-01699-y

Yasuo Imanishi, Tomoe Hirakawa, Waka Haruyama, Keigo Tsushida, Mariko Sakai, Tetsuya Kitayama, Takehisa Kawata, Emi Donoue, Keisuke Inoue, Ikue Kobayashi, Yuki Nagata, Masafumi Kurajoh, Tetsuo Shoji, Andrew Arnold, Masanori Emoto

{"title":"Evocalcet improved the PTH-calcium setpoint and suppressed parathyroid proliferation in mice model of primary hyperparathyroidism.","authors":"Yasuo Imanishi, Tomoe Hirakawa, Waka Haruyama, Keigo Tsushida, Mariko Sakai, Tetsuya Kitayama, Takehisa Kawata, Emi Donoue, Keisuke Inoue, Ikue Kobayashi, Yuki Nagata, Masafumi Kurajoh, Tetsuo Shoji, Andrew Arnold, Masanori Emoto","doi":"10.1007/s00774-026-01699-y","DOIUrl":"10.1007/s00774-026-01699-y","url":null,"abstract":"Background: Evocalcet is an allosteric modulator of the calcium-sensing receptor (CaSR) that effectively suppresses parathyroid hormone (PTH) secretion in both primary and secondary hyperparathyroidism. However, its effects on the PTH-calcium setpoint and parathyroid cell proliferation remain unclear.Methods: We investigated these effects using the PC mouse model of primary hyperparathyroidism, which is characterized by parathyroid-targeted cyclin D1 overexpression . Evocalcet was administered orally at a dose of 0.025 mg/g diet. The PTH-calcium setpoint was evaluated, and the antiproliferative effect of evocalcet on parathyroid cells was assessed using 5-bromo-2'-deoxyuridine (BrdU) incorporation assays. The effects of evocalcet were compared with those of cinacalcet. Expression levels of the vitamin D receptor (VDR) and CaSR in parathyroid glands were also examined.Results: Evocalcet significantly reduced the PTH-calcium setpoint in PC mice, restoring it to levels comparable to those observed in wild-type controls. Evocalcet treatment markedly decreased the proportion of BrdU-positive parathyroid cells, indicating suppression of parathyroid cell proliferation. This antiproliferative effect was comparable to that observed with cinacalcet. Neither evocalcet nor cinacalcet altered VDR or CaSR expression in the parathyroid glands.Conclusions: Evocalcet, similar to cinacalcet, lowers the PTH-calcium setpoint and inhibits parathyroid cell proliferation in a mouse model of primary hyperparathyroidism. These findings suggest that evocalcet may not only reduce PTH secretion but also attenuate disease progression in hyperparathyroidism.","PeriodicalId":15116,"journal":{"name":"Journal of Bone and Mineral Metabolism","volume":" ","pages":"302-311"},"PeriodicalIF":2.9,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13246816/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146213300","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Response to the letter regarding "One-year bone mineral density gains with anti-osteoporotic medications and clinical factors associated with non-BMD gainers". 关于“抗骨质疏松药物一年骨密度增加和与非骨密度增加相关的临床因素”的信的回应。

IF 2.9 3区医学

Journal of Bone and Mineral Metabolism Pub Date : 2026-05-01 Epub Date: 2026-01-21 DOI: 10.1007/s00774-025-01676-x

Seol A Jang, Seok-Jae Heo, Su Jin Kwon, Chul Sik Kim, Seok Won Park, Kyoung Min Kim

引用次数: 0

Bone mineral density after spinal cord injury: assessment of hip and knee measurements-response to the Letter to Editor. 脊髓损伤后的骨矿物质密度：髋关节和膝关节测量的评估——对致编辑信的回应。

IF 2.9 3区医学

Journal of Bone and Mineral Metabolism Pub Date : 2026-05-01 Epub Date: 2025-12-29 DOI: 10.1007/s00774-025-01675-y

Nurdan Korkmaz, Gökhan Yardımcı, Ayşe Naz Kalem Özgen, Özlem Köroğlu, Bilge Yılmaz

引用次数: 0

Identifying the clinical indicator for surgical intervention in medication-related osteonecrosis of the jaw. 确定药物相关性颌骨骨坏死手术干预的临床指标。

IF 2.9 3区医学

Journal of Bone and Mineral Metabolism Pub Date : 2026-05-01 Epub Date: 2026-01-22 DOI: 10.1007/s00774-025-01687-8

Yoshiaki Tadokoro, Takumi Hasegawa, Daisuke Takeda, Junya Hirota, Kaito Uryu, Tatsuya Shirai, Yumi Muraki, Masaya Akashi

{"title":"Identifying the clinical indicator for surgical intervention in medication-related osteonecrosis of the jaw.","authors":"Yoshiaki Tadokoro, Takumi Hasegawa, Daisuke Takeda, Junya Hirota, Kaito Uryu, Tatsuya Shirai, Yumi Muraki, Masaya Akashi","doi":"10.1007/s00774-025-01687-8","DOIUrl":"10.1007/s00774-025-01687-8","url":null,"abstract":"Introduction: Surgery has increasingly been reported as an effective treatment for medication-related osteonecrosis of the jaw (MRONJ), but concrete intervention criteria are lacking. On computed tomography (CT) images, the boundary between the healthy site and necrotic lesion, which we defined as \"MRONJ demarcation line\", is sometimes visible. This study aimed to identify the factors associated with this boundary to improve surgical planning.Materials and methods: 95 patients with MRONJ who underwent their first CT at our institution between May 2010 and June 2022 were included. The Mann-Whitney U test, Fisher's exact test, and multivariate logistic regression analysis were performed. The cumulative incidence rates were calculated using the Kaplan-Meier method. Statistical significance was set at p < 0.05.Results: MRONJ demarcation line was observed in 63 patients and absent in 32. Significant associations were identified between MRONJ demarcation line formation and denosumab (p = 0.013), antiresorptive agent (ARA) discontinuation (p = 0.024), and periosteal reaction ( p = 0.034). The cumulative incidence rates of MRONJ demarcation line formation at 12, 24, and 36 months after discontinuation of high-dose ARA were 58.0%, 89.2%, and 96.4% for denosumab, and 29.9%, 68.8%, and 88.3% for bisphosphonates, respectively. In the low-dose group, the rates at 12, 24, and 36 months after discontinuation of denosumab were 41.7%, 51.4%, and 63.5%, respectively, while those for bisphosphonates were 22.2%, 35.8%, and 51.1%.Conclusion: Denosumab administration, ARA discontinuation, and periosteal reaction are significantly associated with the MRONJ demarcation line, which may help in establishing criteria for surgical intervention.","PeriodicalId":15116,"journal":{"name":"Journal of Bone and Mineral Metabolism","volume":" ","pages":"346-353"},"PeriodicalIF":2.9,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13246828/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146018104","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0