Journal of Caffeine and Adenosine Research最新文献_第2页

Coffee but Not Caffeine Consumption Reduces the Reward Value of Coffee 喝咖啡而不是咖啡因会降低咖啡的奖励价值

IF 1.7

Journal of Caffeine and Adenosine Research Pub Date : 2020-12-01 DOI: 10.1089/caff.2020.0010

P. Rogers, Annabel Larke, Hope Mayhew, Sophie Tupper

引用次数: 0

Adenosinergic-Dopaminergic Signaling in Mood Disorders: A Mini-Review 情绪障碍中的腺苷能多巴胺能信号传导：综述

IF 1.7

Journal of Caffeine and Adenosine Research Pub Date : 2020-09-16 DOI: 10.1089/caff.2020.0009

M. C. B. Gonçalves, T. Glaser, Sophia L. B. Oliveira, H. Ulrich

引用次数: 1

Adenosine and Ketogenic Treatments. 腺苷和生酮治疗。

IF 1.7

Journal of Caffeine and Adenosine Research Pub Date : 2020-09-01 Epub Date: 2020-09-16 DOI: 10.1089/caff.2020.0011

David N Ruskin, Masahito Kawamura, Susan A Masino

{"title":"Adenosine and Ketogenic Treatments.","authors":"David N Ruskin, Masahito Kawamura, Susan A Masino","doi":"10.1089/caff.2020.0011","DOIUrl":"https://doi.org/10.1089/caff.2020.0011","url":null,"abstract":"It is well known that the neuromodulator adenosine, acting through the adenosine A1 receptor subtype, can limit or stop seizures. In 2008, adenosine was proposed as a key component of the anticonvulsant mechanism of the ketogenic diet (KD), a very low carbohydrate diet that can be highly effective in drug-refractory epilepsy. In this study, we review the accumulated data on the intersection among adenosine, ketosis, and anticonvulsant/antiepileptogenic effects. In several rodent models of epilepsy and seizures, antiseizure effects of ketogenic treatments (the KD itself, exogenous ketone bodies, medium-chain triglycerides or fatty acids) are reversed by administration of an adenosine A1 receptor antagonist. In addition, KD treatment elevates extracellular adenosine and tissue adenosine content in brain. Efforts to maintain or mimic a ketogenic milieu in brain slices reveal a state of reduced excitability produced by pre- and postsynaptic adenosine A1 receptor-based effects. Long-lasting seizure reduction may be due to adenosine-based epigenetic effects. In conclusion, there is accumulating evidence for an adenosinergic anticonvulsant action in the ketogenic state. In some cases, the main trigger is mildly but consistently lowered glucose in the brain. More research is needed to investigate the importance of adenosine in the antiepileptogenic and neuroprotective effects of these treatments. Future research may begin to investigate alternative adenosine-promoting strategies to enhance the KD or to find use as treatments themselves.","PeriodicalId":15112,"journal":{"name":"Journal of Caffeine and Adenosine Research","volume":null,"pages":null},"PeriodicalIF":1.7,"publicationDate":"2020-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1089/caff.2020.0011","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38400390","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 11

Caffeine as a Tool to Explore Active Cognitive Processing Stages in Two-Choice Tasks. 咖啡因作为探索双选择任务中主动认知加工阶段的工具。

IF 1.7

Journal of Caffeine and Adenosine Research Pub Date : 2020-06-01 Epub Date: 2020-06-04 DOI: 10.1089/caff.2019.0021

Robert J Barry, Jack S Fogarty, Frances M De Blasio

引用次数: 2

The Yin and Yang of Adenosine Receptors: A Piquant Story 腺苷受体的阴阳

IF 1.7

Journal of Caffeine and Adenosine Research Pub Date : 2020-06-01 DOI: 10.1089/caff.2020.0004

A. Köfalvi

引用次数: 0

Role of Adenosine in Epilepsy and Seizures. 腺苷在癫痫和癫痫发作中的作用。

IF 1.7

Journal of Caffeine and Adenosine Research Pub Date : 2020-06-01 Epub Date: 2020-06-04 DOI: 10.1089/caff.2019.0022

Fabio C Tescarollo, Diogo M Rombo, Lindsay K DeLiberto, Denise E Fedele, Enmar Alharfoush, Ângelo R Tomé, Rodrigo A Cunha, Ana M Sebastião, Detlev Boison

{"title":"Role of Adenosine in Epilepsy and Seizures.","authors":"Fabio C Tescarollo, Diogo M Rombo, Lindsay K DeLiberto, Denise E Fedele, Enmar Alharfoush, Ângelo R Tomé, Rodrigo A Cunha, Ana M Sebastião, Detlev Boison","doi":"10.1089/caff.2019.0022","DOIUrl":"10.1089/caff.2019.0022","url":null,"abstract":"Adenosine is an endogenous anticonvulsant and neuroprotectant of the brain. Seizure activity produces large quantities of adenosine, and it is this seizure-induced adenosine surge that normally stops a seizure. However, within the context of epilepsy, adenosine plays a wide spectrum of different roles. It not only controls seizures (ictogenesis), but also plays a major role in processes that turn a normal brain into an epileptic brain (epileptogenesis). It is involved in the control of abnormal synaptic plasticity and neurodegeneration and plays a major role in the expression of comorbid symptoms and complications of epilepsy, such as sudden unexpected death in epilepsy (SUDEP). Given the important role of adenosine in epilepsy, therapeutic strategies are in development with the goal to utilize adenosine augmentation not only for the suppression of seizures but also for disease modification and epilepsy prevention, as well as strategies to block adenosine A2A receptor overfunction associated with neurodegeneration. This review provides a comprehensive overview of the role of adenosine in epilepsy.","PeriodicalId":15112,"journal":{"name":"Journal of Caffeine and Adenosine Research","volume":null,"pages":null},"PeriodicalIF":1.7,"publicationDate":"2020-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7301316/pdf/caff.2019.0022.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38068354","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effects of Preinjury and Postinjury Exposure to Caffeine in a Rat Model of Traumatic Brain Injury. 创伤性脑损伤大鼠模型损伤前和损伤后咖啡因暴露的影响。

IF 1.7

Journal of Caffeine and Adenosine Research Pub Date : 2020-03-01 Epub Date: 2020-03-04 DOI: 10.1089/caff.2019.0012

Theresa A Lusardi, Nikki K Lytle, Hoda M Gebril, Detlev Boison

{"title":"Effects of Preinjury and Postinjury Exposure to Caffeine in a Rat Model of Traumatic Brain Injury.","authors":"Theresa A Lusardi, Nikki K Lytle, Hoda M Gebril, Detlev Boison","doi":"10.1089/caff.2019.0012","DOIUrl":"10.1089/caff.2019.0012","url":null,"abstract":"Background: Lethal apnea is a significant cause of acute mortality following a severe traumatic brain injury (TBI). TBI is associated with a surge of adenosine, which also suppresses respiratory function in the brainstem. Methods and Materials: This study examined the acute and chronic effects of caffeine, an adenosine receptor antagonist, on acute mortality and morbidity after fluid percussion injury. Results: We demonstrate that, regardless of preinjury caffeine exposure, an acute bolus of caffeine given immediately following the injury dosedependently prevented lethal apnea and has no detrimental effects on motor performance following sublethal injuries. Finally, we demonstrate that chronic caffeine treatment after injury, but not caffeine withdrawal, impairs recovery of motor function. Conclusions: Preexposure of the injured brain to caffeine does not have a major impact on acute and delayed outcome parameters; more importantly, a single acute dose of caffeine after the injury can prevent lethal apnea regardless of chronic caffeine preexposure.","PeriodicalId":15112,"journal":{"name":"Journal of Caffeine and Adenosine Research","volume":null,"pages":null},"PeriodicalIF":1.7,"publicationDate":"2020-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7071069/pdf/caff.2019.0012.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37745661","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Call for Papers: Adenosine in the Central Nervous System 论文征集：中枢神经系统中的腺苷

IF 1.7

Journal of Caffeine and Adenosine Research Pub Date : 2020-03-01 DOI: 10.1089/caff.2019.29017.cfp

Editor-in-Chief Sergi Ferré

引用次数: 0

Prevalence and Correlates of Caffeine Use Disorder Symptoms Among a United States Sample. 美国样本中咖啡因使用障碍症状的患病率及其相关因素

IF 1.7

Journal of Caffeine and Adenosine Research Pub Date : 2020-03-01 Epub Date: 2020-03-04 DOI: 10.1089/caff.2019.0020

Mary M Sweeney, Darian C Weaver, Kathryn B Vincent, Amelia M Arria, Roland R Griffiths

{"title":"Prevalence and Correlates of Caffeine Use Disorder Symptoms Among a United States Sample.","authors":"Mary M Sweeney, Darian C Weaver, Kathryn B Vincent, Amelia M Arria, Roland R Griffiths","doi":"10.1089/caff.2019.0020","DOIUrl":"https://doi.org/10.1089/caff.2019.0020","url":null,"abstract":"Background: The DSM-5 recognizes caffeine use disorder as a condition for further study, but there is a need to better understand its prevalence and clinical significance among the general population. Methods: A survey was conducted among an online sample of 1006 caffeine-consuming adults using demographic quotas to reflect the U.S. population. Caffeine consumption, DSM-proposed criteria for caffeine use disorder, sleep, substance use, and psychological distress were assessed. Results: Eight percent of the sample fulfilled DSM-proposed criteria for caffeine use disorder. These individuals consumed more caffeine, were younger, and were more likely to be cigarette smokers. Fulfilling caffeine use disorder criteria was associated with caffeine-related functional impairment, poorer sleep, some substance use, as well as greater depression, anxiety, and stress. Conclusions: The prevalence of caffeine use disorder among the present sample suggests that the proposed diagnostic criteria would identify only a modest percentage of the general population, and that identified individuals experience significant caffeine-related distress.","PeriodicalId":15112,"journal":{"name":"Journal of Caffeine and Adenosine Research","volume":null,"pages":null},"PeriodicalIF":1.7,"publicationDate":"2020-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1089/caff.2019.0020","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37745659","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 9

Call for Papers: Adenosine in Inflammation and Cancer 征文:炎症和癌症中的腺苷

IF 1.7

Journal of Caffeine and Adenosine Research Pub Date : 2019-12-01 DOI: 10.1089/caff.2019.29016.cfp

Editor-in-Chief Sergi Ferré

引用次数: 0