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Journal of Caffeine and Adenosine Research最新文献

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Adenosine and Adenosine A2AReceptors as Targets for the Treatment of Niemann Pick Type C Disease 腺苷和腺苷a2a受体作为治疗C型尼曼匹克病的靶点
IF 1.7
Journal of Caffeine and Adenosine Research Pub Date : 2019-09-17 DOI: 10.1089/caff.2019.0014
FerranteAntonella, VisentinSergio, De NuccioChiara, MartireAlberto, PopoliPatrizia
{"title":"Adenosine and Adenosine A2AReceptors as Targets for the Treatment of Niemann Pick Type C Disease","authors":"FerranteAntonella, VisentinSergio, De NuccioChiara, MartireAlberto, PopoliPatrizia","doi":"10.1089/caff.2019.0014","DOIUrl":"https://doi.org/10.1089/caff.2019.0014","url":null,"abstract":"Niemann Pick type C (NPC) is a rare neurovisceral disorder characterized by progressive hepatosplenomegaly, neurodegeneration, and premature death; it is caused by mutations in genes coding for two...","PeriodicalId":15112,"journal":{"name":"Journal of Caffeine and Adenosine Research","volume":null,"pages":null},"PeriodicalIF":1.7,"publicationDate":"2019-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1089/caff.2019.0014","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42744050","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Adenosine: A Complex Role in Neurodegeneration 腺苷:在神经变性中的复杂作用
IF 1.7
Journal of Caffeine and Adenosine Research Pub Date : 2019-09-17 DOI: 10.1089/caff.2019.29015.dbl
D. Blum
{"title":"Adenosine: A Complex Role in Neurodegeneration","authors":"D. Blum","doi":"10.1089/caff.2019.29015.dbl","DOIUrl":"https://doi.org/10.1089/caff.2019.29015.dbl","url":null,"abstract":"","PeriodicalId":15112,"journal":{"name":"Journal of Caffeine and Adenosine Research","volume":null,"pages":null},"PeriodicalIF":1.7,"publicationDate":"2019-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1089/caff.2019.29015.dbl","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41839379","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Novel Players in the Aging Synapse: Impact on Cognition. 衰老突触中的小说玩家：对认知的影响。
IF 1.7
Journal of Caffeine and Adenosine Research Pub Date : 2019-09-01 Epub Date: 2019-09-17 DOI: 10.1089/caff.2019.0013
Mariana Temido-Ferreira, Joana E Coelho, Paula A Pousinha, Luísa V Lopes
{"title":"Novel Players in the Aging Synapse: Impact on Cognition.","authors":"Mariana Temido-Ferreira, Joana E Coelho, Paula A Pousinha, Luísa V Lopes","doi":"10.1089/caff.2019.0013","DOIUrl":"10.1089/caff.2019.0013","url":null,"abstract":"<p><p>While neuronal loss has long been considered as the main contributor to age-related cognitive decline, these alterations are currently attributed to gradual synaptic dysfunction driven by calcium dyshomeostasis and alterations in ionotropic/metabotropic receptors. Given the key role of the hippocampus in encoding, storage, and retrieval of memory, the morpho- and electrophysiological alterations that occur in the major synapse of this network-the glutamatergic-deserve special attention. We guide you through the hippocampal anatomy, circuitry, and function in physiological context and focus on alterations in neuronal morphology, calcium dynamics, and plasticity induced by aging and Alzheimer's disease (AD). We provide state-of-the art knowledge on glutamatergic transmission and discuss implications of these novel players for intervention. A link between regular consumption of caffeine-an adenosine receptor blocker-to decreased risk of AD in humans is well established, while the mechanisms responsible have only now been uncovered. We review compelling evidence from humans and animal models that implicate adenosine A<sub>2A</sub> receptors (A<sub>2A</sub>R) upsurge as a crucial mediator of age-related synaptic dysfunction. The relevance of this mechanism in patients was very recently demonstrated in the form of a significant association of the A<sub>2A</sub>R-encoding gene with hippocampal volume (synaptic loss) in mild cognitive impairment and AD. Novel pathways implicate A<sub>2A</sub>R in the control of mGluR5-dependent NMDAR activation and subsequent Ca<sup>2+</sup> dysfunction upon aging. The nature of this receptor makes it particularly suited for long-term therapies, as an alternative for regulating aberrant mGluR5/NMDAR signaling in aging and disease, without disrupting their crucial constitutive activity.</p>","PeriodicalId":15112,"journal":{"name":"Journal of Caffeine and Adenosine Research","volume":null,"pages":null},"PeriodicalIF":1.7,"publicationDate":"2019-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/6c/bb/caff.2019.0013.PMC6761599.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41201880","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Functional and Neuroprotective Role of Striatal Adenosine A2A Receptor Heterotetramers 纹状体腺苷A2A受体异四聚体的功能和神经保护作用
IF 1.7
Journal of Caffeine and Adenosine Research Pub Date : 2019-09-01 DOI: 10.1089/caff.2019.0008
S. Ferré, F. Ciruela
{"title":"Functional and Neuroprotective Role of Striatal Adenosine A2A Receptor Heterotetramers","authors":"S. Ferré, F. Ciruela","doi":"10.1089/caff.2019.0008","DOIUrl":"https://doi.org/10.1089/caff.2019.0008","url":null,"abstract":"In the striatum, adenosine A2A receptors (A2AR) are mainly expressed within the soma and dendrites of the striatopallidal neuron. A predominant proportion of these striatal postsynaptic A2AR form part of the macromolecular complexes that include A2AR-dopamine D2 receptor (D2R) heteromers, Golf and Gi/o proteins, and the effector adenylyl cyclase (AC), subtype AC5. The A2AR-D2R heteromers have a tetrameric structure, constituted by A2AR and D2R homomers. By means of reciprocal antagonistic allosteric interactions and antagonistic interactions at the effector level between adenosine and dopamine, the A2AR-D2R heterotetramer-AC5 complex acts an integrative molecular device, which determines a switch between the adenosine-facilitated activation and the dopamine-facilitated inhibition of the striatopallidal neuron. Striatal adenosine also plays an important presynaptic modulatory role, driving the function of corticostriatal terminals. This control is mediated by adenosine A1 receptors (A1R) and A2AR, which establish intermolecular interactions forming A1R-A2AR heterotetramers. Here, we review the functional role of both presynaptic and postsynaptic striatal A2AR heterotetramers as well as their possible neuroprotective role. We hypothesize that alterations in the homomer/heteromer stoichiometry (i.e., increase or decrease in the proportion of A2AR forming homomers or heteromers) are pathogenetically involved in neurological disorders, specifically in Parkinson's disease and restless legs syndrome.","PeriodicalId":15112,"journal":{"name":"Journal of Caffeine and Adenosine Research","volume":null,"pages":null},"PeriodicalIF":1.7,"publicationDate":"2019-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1089/caff.2019.0008","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43198180","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 29
Neurogenetics of the Human Adenosine Receptor Genes: Genetic Structures and Involvement in Brain Diseases 人类腺苷受体基因的神经遗传学：遗传结构与脑疾病的关系
IF 1.7
Journal of Caffeine and Adenosine Research Pub Date : 2019-09-01 DOI: 10.1089/caff.2019.0011
V. Huin, C. Dhaenens, Mégane Homa, Kevin Carvalho, L. Buée, B. Sablonnière
{"title":"Neurogenetics of the Human Adenosine Receptor Genes: Genetic Structures and Involvement in Brain Diseases","authors":"V. Huin, C. Dhaenens, Mégane Homa, Kevin Carvalho, L. Buée, B. Sablonnière","doi":"10.1089/caff.2019.0011","DOIUrl":"https://doi.org/10.1089/caff.2019.0011","url":null,"abstract":"Adenosine receptors are G-protein-coupled receptors involved in a wide range of physiological and pathological phenomena in most mammalian systems. All four receptors are widely expressed in the ce...","PeriodicalId":15112,"journal":{"name":"Journal of Caffeine and Adenosine Research","volume":null,"pages":null},"PeriodicalIF":1.7,"publicationDate":"2019-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1089/caff.2019.0011","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46582385","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 10
The Journal of Caffeine and Adenosine Research Welcomes Your Ideas, Research, and Feedback 咖啡因和腺苷研究杂志欢迎您的想法、研究和反馈
IF 1.7
Journal of Caffeine and Adenosine Research Pub Date : 2019-06-19 DOI: 10.1089/CAFF.2019.29012.KCH
Cloud-HansenKaren
{"title":"The Journal of Caffeine and Adenosine Research Welcomes Your Ideas, Research, and Feedback","authors":"Cloud-HansenKaren","doi":"10.1089/CAFF.2019.29012.KCH","DOIUrl":"https://doi.org/10.1089/CAFF.2019.29012.KCH","url":null,"abstract":"","PeriodicalId":15112,"journal":{"name":"Journal of Caffeine and Adenosine Research","volume":null,"pages":null},"PeriodicalIF":1.7,"publicationDate":"2019-06-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1089/CAFF.2019.29012.KCH","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43243456","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Beneficial Effects of Postnatal Caffeine on Spatial Learning in Adult Mice 出生后咖啡因对成年小鼠空间学习的有益作用
IF 1.7
Journal of Caffeine and Adenosine Research Pub Date : 2019-06-19 DOI: 10.1089/CAFF.2018.0021
S. Pratap, XuYing, WangHuamei, H S KumarVasantha
{"title":"The Beneficial Effects of Postnatal Caffeine on Spatial Learning in Adult Mice","authors":"S. Pratap, XuYing, WangHuamei, H S KumarVasantha","doi":"10.1089/CAFF.2018.0021","DOIUrl":"https://doi.org/10.1089/CAFF.2018.0021","url":null,"abstract":"Background: Prenatal caffeine adversely affects learning and memory in adult offspring, whereas its administration to adolescent humans improves consolidation of long-term memory. The effects of po...","PeriodicalId":15112,"journal":{"name":"Journal of Caffeine and Adenosine Research","volume":null,"pages":null},"PeriodicalIF":1.7,"publicationDate":"2019-06-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1089/CAFF.2018.0021","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41260455","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
Caffeine Influences Functional Activity and Gene Expression of Bone Marrow Osteoblastic Cells from Osteoporotic Rats 咖啡因对骨质疏松大鼠骨髓成骨细胞功能活性和基因表达的影响
IF 1.7
Journal of Caffeine and Adenosine Research Pub Date : 2019-06-19 DOI: 10.1089/CAFF.2019.0002
F. Rodrigo, Vargas SanchezPaula Katherine, SórioAna Luisa Riul, OliveiraCarolina Alves Freiria de, R. Tavares, de Sousa Luiz Gustavo, RosaAdalberto Luiz, SiéssereSelma, B. Fittipaldi
{"title":"Caffeine Influences Functional Activity and Gene Expression of Bone Marrow Osteoblastic Cells from Osteoporotic Rats","authors":"F. Rodrigo, Vargas SanchezPaula Katherine, SórioAna Luisa Riul, OliveiraCarolina Alves Freiria de, R. Tavares, de Sousa Luiz Gustavo, RosaAdalberto Luiz, SiéssereSelma, B. Fittipaldi","doi":"10.1089/CAFF.2019.0002","DOIUrl":"https://doi.org/10.1089/CAFF.2019.0002","url":null,"abstract":"Background: Considering the high consumption of caffeinated beverages and its skeletal effects after onset of osteoporosis, we aimed to evaluate low and moderate in vitro caffeine concentrations in...","PeriodicalId":15112,"journal":{"name":"Journal of Caffeine and Adenosine Research","volume":null,"pages":null},"PeriodicalIF":1.7,"publicationDate":"2019-06-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1089/CAFF.2019.0002","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49020702","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Caffeinated Alcoholic Beverages and Intimate Partner Violence Victimization. 含咖啡因的酒精饮料与亲密伴侣暴力受害。
IF 1.7
Journal of Caffeine and Adenosine Research Pub Date : 2019-06-01 Epub Date: 2019-06-19 DOI: 10.1089/caff.2018.0018
Cory A Crane, Robert C Schlauch, Kathleen E Miller
{"title":"Caffeinated Alcoholic Beverages and Intimate Partner Violence Victimization.","authors":"Cory A Crane, Robert C Schlauch, Kathleen E Miller","doi":"10.1089/caff.2018.0018","DOIUrl":"10.1089/caff.2018.0018","url":null,"abstract":"<p><p><b><i>Background:</i></b> Caffeinated alcoholic beverage (CAB) use is associated with general victimization beyond the use of alcohol alone. <b><i>Materials and Methods:</i></b> No prior research has evaluated the association between CAB use and intimate partner violence (IPV) victimization. This study evaluated the CAB-IPV victimization relationship using the responses of 100 (40 female) respondents to an online survey. <b><i>Results:</i></b> Results of logistic regression analyses indicated that CAB use was associated with IPV physical and sexual victimization after adjusting for demographics and heavy alcohol use. Exploratory analyses detected little evidence of sex differences in the strength of the relationship between CAB use and IPV victimization. <b><i>Conclusions:</i></b> The current results provide initial evidence that CAB use may place males and females at greater risk of IPV victimization.</p>","PeriodicalId":15112,"journal":{"name":"Journal of Caffeine and Adenosine Research","volume":null,"pages":null},"PeriodicalIF":1.7,"publicationDate":"2019-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6602101/pdf/caff.2018.0018.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37410262","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Caffeine and Bones: If Less Is Good, More May Not Be Better. 咖啡因和骨骼:少喝好，多喝未必更好
IF 1.7
Journal of Caffeine and Adenosine Research Pub Date : 2019-06-01 Epub Date: 2019-06-19 DOI: 10.1089/caff.2019.29011.ah
Luca Antonioli, György Haskó
{"title":"Caffeine and Bones: If Less Is Good, More May Not Be Better.","authors":"Luca Antonioli, György Haskó","doi":"10.1089/caff.2019.29011.ah","DOIUrl":"10.1089/caff.2019.29011.ah","url":null,"abstract":"","PeriodicalId":15112,"journal":{"name":"Journal of Caffeine and Adenosine Research","volume":null,"pages":null},"PeriodicalIF":1.7,"publicationDate":"2019-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6860002/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45869230","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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