Caffeine as a Tool to Explore Active Cognitive Processing Stages in Two-Choice Tasks.

IF 1.7 Q4 Pharmacology, Toxicology and Pharmaceutics

Journal of Caffeine and Adenosine Research Pub Date : 2020-06-01 Epub Date: 2020-06-04 DOI:10.1089/caff.2019.0021

Robert J Barry, Jack S Fogarty, Frances M De Blasio

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引用次数: 2

Abstract

Background: We used caffeine as a tool to explore the active cognitive-processing stages in a simple Go/NoGo task, in terms of the event-related potential (ERP) components elicited by the Go and NoGo stimuli. Methods: Two hundred and fifty milligrams of caffeine was administered to adult participants (N = 24) in a randomized double-blind placebo-controlled repeated-measures crossover study. Two blocks of an equiprobable auditory Go/NoGo task were completed, each with a random mix of 75 tones at 1000 Hz and 75 at 1500 Hz, all 60 dB sound pressure level (SPL). Results: Major ERP effects of caffeine were apparent in enhancements of the Go N1-1, P3b, and Slow Wave (SW), and the NoGo Processing Negativity, SW, and NoGo Late Positivity. Conclusions: Novel differential findings indicate the potential of our caffeine as a tool approach to elucidate the functional nature of ERP markers of active cognitive processing in a range of developmental and clinical populations.

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咖啡因作为探索双选择任务中主动认知加工阶段的工具。

背景:我们利用咖啡因作为工具，通过Go和NoGo刺激引发的事件相关电位(ERP)成分来探索简单Go/NoGo任务中的主动认知加工阶段。方法:在一项随机双盲安慰剂对照重复测量交叉研究中，成人参与者(N = 24)服用250毫克咖啡因。完成了两个等概率听觉Go/NoGo任务，每个任务随机混合75个1000 Hz和75个1500 Hz的音调，所有声压级(SPL)均为60 dB。结果:咖啡因的ERP效应主要表现在Go N1-1、P3b和慢波(SW)，以及NoGo加工负性、SW和NoGo后期正性的增强。结论:新的差异发现表明，我们的咖啡因作为一种工具方法的潜力，阐明积极认知加工的ERP标记在一系列发育和临床人群中的功能性质。

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Journal of Caffeine and Adenosine Research Multiple-

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