Robert J Barry, Jack S Fogarty, Frances M De Blasio
{"title":"Caffeine as a Tool to Explore Active Cognitive Processing Stages in Two-Choice Tasks.","authors":"Robert J Barry, Jack S Fogarty, Frances M De Blasio","doi":"10.1089/caff.2019.0021","DOIUrl":null,"url":null,"abstract":"<p><p><b><i>Background:</i></b> We used caffeine as a tool to explore the active cognitive-processing stages in a simple Go/NoGo task, in terms of the event-related potential (ERP) components elicited by the Go and NoGo stimuli. <b><i>Methods:</i></b> Two hundred and fifty milligrams of caffeine was administered to adult participants (<i>N</i> = 24) in a randomized double-blind placebo-controlled repeated-measures crossover study. Two blocks of an equiprobable auditory Go/NoGo task were completed, each with a random mix of 75 tones at 1000 Hz and 75 at 1500 Hz, all 60 dB sound pressure level (SPL). <b><i>Results:</i></b> Major ERP effects of caffeine were apparent in enhancements of the Go N1-1, P3b, and Slow Wave (SW), and the NoGo Processing Negativity, SW, and NoGo Late Positivity. <b><i>Conclusions:</i></b> Novel differential findings indicate the potential of our caffeine as a tool approach to elucidate the functional nature of ERP markers of active cognitive processing in a range of developmental and clinical populations.</p>","PeriodicalId":15112,"journal":{"name":"Journal of Caffeine and Adenosine Research","volume":null,"pages":null},"PeriodicalIF":1.7000,"publicationDate":"2020-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1089/caff.2019.0021","citationCount":"2","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Caffeine and Adenosine Research","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1089/caff.2019.0021","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2020/6/4 0:00:00","PubModel":"Epub","JCR":"Q4","JCRName":"Pharmacology, Toxicology and Pharmaceutics","Score":null,"Total":0}
引用次数: 2
Abstract
Background: We used caffeine as a tool to explore the active cognitive-processing stages in a simple Go/NoGo task, in terms of the event-related potential (ERP) components elicited by the Go and NoGo stimuli. Methods: Two hundred and fifty milligrams of caffeine was administered to adult participants (N = 24) in a randomized double-blind placebo-controlled repeated-measures crossover study. Two blocks of an equiprobable auditory Go/NoGo task were completed, each with a random mix of 75 tones at 1000 Hz and 75 at 1500 Hz, all 60 dB sound pressure level (SPL). Results: Major ERP effects of caffeine were apparent in enhancements of the Go N1-1, P3b, and Slow Wave (SW), and the NoGo Processing Negativity, SW, and NoGo Late Positivity. Conclusions: Novel differential findings indicate the potential of our caffeine as a tool approach to elucidate the functional nature of ERP markers of active cognitive processing in a range of developmental and clinical populations.