Journal of Caffeine and Adenosine Research最新文献

{"title":"Caffeine Treatment for Apnea of Prematurity and the Influence on Dose-Dependent Postnatal Weight Gain Observed Over 15 Years.","authors":"Roy K Philip,&nbsp;Abu Ismail,&nbsp;Bernadette Murphy,&nbsp;Adnan Mirza,&nbsp;Collette Quinn,&nbsp;Margo Dunworth","doi":"10.1089/caff.2018.0005","DOIUrl":"https://doi.org/10.1089/caff.2018.0005","url":null,"abstract":"<p><p><b><i>Background and Aim:</i></b> To analyze the influence on weight gain of infants exposed to two dosage regimens of oral caffeine citrate (CC) for apnea of prematurity. <b><i>Methods:</i></b> Retrospective descriptive observational study of an eligible very low birth weight cohort over a 15-year period in an Irish University hospital. Data were analyzed between two distinct postnatal ages: 14-28 and 29-56 days. <b><i>Results:</i></b> During the 15-year study, 457 infants were prescribed caffeine. Among the 14-28-day group, after applying exclusion criteria, 418 infants qualified. Two hundred forty-eight infants received 5 mg/(kg·day) and 170 received 10 mg/(kg·day) of CC. Among the 29-56-day group, 362 infants were identified and after applying exclusions, 332 fulfilled entry criteria [214 on 5 mg/(kg·day) and 118 on 10 mg/(kg·day) regimen]. Baseline characteristics of infants were comparable between groups without statistically significant differences. Mean daily weight gain (MDWG) in grams from day 14 to 28 showed a higher rate of increase for the 5 mg/(kg·day) group compared with the 10 mg/(kg·day) group (17.2 ± 12 g vs. 13.0 ± 10.2 g [<i>p</i> = 0.04]). From day 29 to 56, also MDWG was higher among infants on 5 mg/(kg·day) of CC compared with 10 mg/(kg·day) group (15.6 ± 10.8 g vs. 10.2 ± 9.8 g [<i>p</i> = 0.011]). <b><i>Conclusion:</i></b> While a variety of measures are optimized to promote postnatal weight gain of premature infants close to an ideal intrauterine growth curve, not paying sufficient attention to one of the most widely used catabolic agents in neonatology is questionable and warrants vigilance. Additional nutritional measures could be offered to those with prolonged caffeine exposure.</p>","PeriodicalId":15112,"journal":{"name":"Journal of Caffeine and Adenosine Research","volume":null,"pages":null},"PeriodicalIF":1.7,"publicationDate":"2018-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1089/caff.2018.0005","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36520135","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Highs and Lows of Caffeine Intake in New Zealand Children","authors":"Ajmol Ali, C. Wham, F. Wolber, Martin Dickens, K. O'Keeffe, M. Thunders, Judy Thomas, C. Starck, K. Rutherfurd-Markwick","doi":"10.1089/caff.2017.0035","DOIUrl":"https://doi.org/10.1089/caff.2017.0035","url":null,"abstract":"","PeriodicalId":15112,"journal":{"name":"Journal of Caffeine and Adenosine Research","volume":null,"pages":null},"PeriodicalIF":1.7,"publicationDate":"2018-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1089/caff.2017.0035","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"60867889","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Maintenance of Vagal Tone with Time-Release Caffeine, But Vagal Withdrawal During Placebo in Caffeine-Habituated Men","authors":"Michael B. La Monica, D. Fukuda, Ran Wang, Adam M. Gonzalez, Adam J. Wells, J. Hoffman, Jeffrey R Stout","doi":"10.1089/CAFF.2017.0039","DOIUrl":"https://doi.org/10.1089/CAFF.2017.0039","url":null,"abstract":"Objective: This study aimed to determine the effects of a time-release caffeine (TR-CAF) supplement and caffeine abstinence on heart rate variability (HRV) in habitual users. Methods: Ten caffeine-habituated (>200 mg per day) men (25.9 ± 3.2 years; 1.81 ± 0.08 m; and 92.9 ± 9.9 kg) performed three trials, each separated by 1 week. During each trial, participants randomly consumed either 194 mg of caffeine in a multi-ingredient supplement containing TR-CAF; an instant-release caffeine supplement (CAF); or placebo (PL). HRV was assessed for 10 minutes in the supine position at baseline (BL), and every hour after supplementation for 8 hours. Time-domain [average heart rate, mean standard deviation of all normal-to-normal (NN) intervals (SDNN), and root mean square of differences between adjacent NN intervals (RMSSD)] and frequency-domain [low frequency (LF), high frequency (HF), total power (TP), LF/HF, and an index of parasympathetic nervous system (PNS = HF/TP)] measures were recorded. A two-way (trial × t...","PeriodicalId":15112,"journal":{"name":"Journal of Caffeine and Adenosine Research","volume":null,"pages":null},"PeriodicalIF":1.7,"publicationDate":"2018-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1089/CAFF.2017.0039","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47605706","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Effect of the CYP1A2 −163 C > A Polymorphism on Caffeine Metabolism and Subsequent Cycling Performance","authors":"Gabrielle E. W. Giersch, J. Boyett, T. Hargens, N. Luden, M. Saunders, Hannah M. Daley, C. A. Hughey, A. El-Sohemy, C. Womack","doi":"10.1089/caff.2017.0028","DOIUrl":"https://doi.org/10.1089/caff.2017.0028","url":null,"abstract":"","PeriodicalId":15112,"journal":{"name":"Journal of Caffeine and Adenosine Research","volume":null,"pages":null},"PeriodicalIF":1.7,"publicationDate":"2018-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1089/caff.2017.0028","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"60868284","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Role of Adenosine Tone and Adenosine Receptors in Huntington's Disease.","authors":"David Blum, Yijuang Chern, Maria Rosaria Domenici, Luc Buée, Chien-Yu Lin, William Rea, Sergi Ferré, Patrizia Popoli","doi":"10.1089/caff.2018.0006","DOIUrl":"10.1089/caff.2018.0006","url":null,"abstract":"<p><p>Huntington's disease (HD) is a hereditary neurodegenerative disorder caused by a mutation in the IT15 gene that encodes for the huntingtin protein. Mutated hungtingtin, although widely expressed in the brain, predominantly affects striato-pallidal neurons, particularly enriched with adenosine A_2A receptors (A_2AR), suggesting a possible involvement of adenosine and A_2AR is the pathogenesis of HD. In fact, polymorphic variation in the <i>ADORA2A</i> gene influences the age at onset in HD, and A_2AR dynamics is altered by mutated huntingtin. Basal levels of adenosine and adenosine receptors are involved in many processes critical for neuronal function and homeostasis, including modulation of synaptic activity and excitotoxicity, the control of neurotrophin levels and functions, and the regulation of protein degradation mechanisms. In the present review, we critically analyze the current literature involving the effect of altered adenosine tone and adenosine receptors in HD and discuss why therapeutics that modulate the adenosine system may represent a novel approach for the treatment of HD.</p>","PeriodicalId":15112,"journal":{"name":"Journal of Caffeine and Adenosine Research","volume":null,"pages":null},"PeriodicalIF":1.7,"publicationDate":"2018-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6049521/pdf/caff.2018.0006.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36326617","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Caffeine Intake and Its Association with Body Composition Measures and Macronutrient Intakes in People Living with HIV in the Miami Adult Studies on HIV Cohort.","authors":"Venkataraghavan Ramamoorthy, Adriana Campa, Muni Rubens, Sabrina S Martinez, Christina Fleetwood, Tiffanie Stewart, Juan P Liuzzi, Florence George, Hafiz Khan, Yinghui Li, Marianna Baum","doi":"10.1089/caff.2017.0026","DOIUrl":"10.1089/caff.2017.0026","url":null,"abstract":"<p><p><b><i>Background:</i></b> Caffeine acts as an anorexic agent, increases energy expenditures, and decreases total body fat mass, and could be detrimental to people living with HIV (PLWH). The objective of this study was to explore the relationship between caffeine consumption, body composition measures (fat mass, body mass index [BMI], and lean body mass [LBM]), nutrient intakes, CD4 counts, and HIV viral load in PLWH. <b><i>Methods:</i></b> A convenience sample of 130 PLWH was recruited and followed for 3 months. Caffeine intake, body composition measures, and nutrient intakes were collected using Modified Caffeine Consumption Questionnaire, bioimpedance analyses, and 24-hour dietary recalls. Linear regressions were used to analyze the baseline data for relationships between these variables. Linear mixed models (LMMs) were used to determine the overtime changes. <b><i>Results:</i></b> In baseline, linear regression analysis, higher caffeine consumption was associated with lower fat mass (β = -0.994, <i>p</i> = 0.042). However, BMI and LBM did not show any significant association with caffeine intake. LMM analysis showed that the association between caffeine intake and fat mass strengthened overtime (β = -1.987, <i>p</i> = 0.035). Baseline linear regression analysis showed that higher caffeine intake was significantly associated with lower caloric intakes from fat (β = -1.902, <i>p</i> = 0.044) and lower total caloric intake (β = -1.643, <i>p</i> = 0.042). However, LMM analysis showed that these associations diminished and lost significance overtime. There were no associations between body composition measures, nutrient intakes, CD4 counts, and HIV viral load. <b><i>Conclusions:</i></b> Caffeine intake adversely affected dietary intakes of macronutrients and total fat mass. Therefore, caffeine, a known anorectic, should be regulated in PLWH.</p>","PeriodicalId":15112,"journal":{"name":"Journal of Caffeine and Adenosine Research","volume":null,"pages":null},"PeriodicalIF":1.7,"publicationDate":"2018-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6049520/pdf/caff.2017.0026.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36326616","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Special Announcement: Publication Opportunity for Undergraduates","authors":"","doi":"10.1089/caff.2021.29018.kch","DOIUrl":"https://doi.org/10.1089/caff.2021.29018.kch","url":null,"abstract":"","PeriodicalId":15112,"journal":{"name":"Journal of Caffeine and Adenosine Research","volume":null,"pages":null},"PeriodicalIF":1.7,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"60868092","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}