Journal of Aging Research最新文献

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Logistic Regression Model in a Machine Learning Application to Predict Elderly Kidney Transplant Recipients with Worse Renal Function One Year after Kidney Transplant: Elderly KTbot. 逻辑回归模型在机器学习应用中预测肾移植后一年内肾功能恶化的老年肾移植受者:老年KTbot。
IF 4.7
Journal of Aging Research Pub Date : 2020-08-19 eCollection Date: 2020-01-01 DOI: 10.1155/2020/7413616
Ubiracé Fernando Elihimas Júnior, Jamila Pinho Couto, Wallace Pereira, Michel Pompeu Barros de Oliveira Sá, Eduardo Eriko Tenório de França, Filipe Carrilho Aguiar, Diogo Buarque Cordeiro Cabral, Saulo Barbosa Vasconcelos Alencar, Saulo José da Costa Feitosa, Thais Oliveira Claizoni Dos Santos, Helen Conceição Dos Santos Elihimas, Emilly Pereira Alves, Marcio José de Carvalho Lima, Frederico Castelo Branco Cavalcanti, Paulo Adriano Schwingel
{"title":"Logistic Regression Model in a Machine Learning Application to Predict Elderly Kidney Transplant Recipients with Worse Renal Function One Year after Kidney Transplant: Elderly KTbot.","authors":"Ubiracé Fernando Elihimas Júnior,&nbsp;Jamila Pinho Couto,&nbsp;Wallace Pereira,&nbsp;Michel Pompeu Barros de Oliveira Sá,&nbsp;Eduardo Eriko Tenório de França,&nbsp;Filipe Carrilho Aguiar,&nbsp;Diogo Buarque Cordeiro Cabral,&nbsp;Saulo Barbosa Vasconcelos Alencar,&nbsp;Saulo José da Costa Feitosa,&nbsp;Thais Oliveira Claizoni Dos Santos,&nbsp;Helen Conceição Dos Santos Elihimas,&nbsp;Emilly Pereira Alves,&nbsp;Marcio José de Carvalho Lima,&nbsp;Frederico Castelo Branco Cavalcanti,&nbsp;Paulo Adriano Schwingel","doi":"10.1155/2020/7413616","DOIUrl":"https://doi.org/10.1155/2020/7413616","url":null,"abstract":"<p><strong>Background: </strong>Renal replacement therapy (RRT) is a public health problem worldwide. Kidney transplantation (KT) is the best treatment for elderly patients' longevity and quality of life.</p><p><strong>Objectives: </strong>The primary endpoint was to compare elderly versus younger KT recipients by analyzing the risk covariables involved in worsening renal function, proteinuria, graft loss, and death one year after KT. The secondary endpoint was to create a robot based on logistic regression capable of predicting the likelihood that elderly recipients will develop worse renal function one year after KT.</p><p><strong>Method: </strong>Unicentric retrospective analysis of a cohort was performed with individuals aged ≥60 and <60 years old. We analysed medical records of KT recipients from January to December 2017, with a follow-up time of one year after KT. We used multivariable logistic regression to estimate odds ratios for elderly vs younger recipients, controlled for demographic, clinical, laboratory, data pre- and post-KT, and death.</p><p><strong>Results: </strong>18 elderly and 100 younger KT recipients were included. Pretransplant immune variables were similar between two groups. No significant differences (<i>P</i> > 0.05) between groups were observed after KT on laboratory data means and for the prevalences of diabetes mellitus, hypertension, acute rejection, cytomegalovirus, polyomavirus, and urinary infections. One year after KT, the creatinine clearance was higher (<i>P</i> = 0.006) in youngers (70.9 ± 25.2 mL/min/1.73 m<sup>2</sup>) versus elderlies (53.3 ± 21.1 mL/min/1.73 m<sup>2</sup>). There was no difference in death outcome comparison. Multivariable analysis among covariables predisposing chronic kidney disease epidemiology collaboration (CKD-EPI) equation <60 mL/min/1.73 m<sup>2</sup> presented a statistical significance for age ≥60 years (<i>P</i> = 0.01) and reduction in serum haemoglobin (<i>P</i> = 0.03). The model presented goodness-fit in the evaluation of artificial intelligence metrics (precision: 90%; sensitivity: 71%; and <i>F</i> <sub>1</sub> score: 0.79).</p><p><strong>Conclusion: </strong>Renal function in elderly KT recipients was lower than in younger KT recipients. However, patients aged ≥60 years maintained enough renal function to remain off dialysis. Moreover, a learning machine application built a robot (Elderly KTbot) to predict in the elderly populations the likelihood of worse renal function one year after KT.</p>","PeriodicalId":14933,"journal":{"name":"Journal of Aging Research","volume":"2020 ","pages":"7413616"},"PeriodicalIF":4.7,"publicationDate":"2020-08-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2020/7413616","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38376190","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 5
Morale in Old Age and Its Association with Sociodemographic, Social, and Health-Related Factors in Different Age Groups. 老年士气及其与不同年龄组社会人口、社会和健康相关因素的关系
IF 4.7
Journal of Aging Research Pub Date : 2020-08-01 eCollection Date: 2020-01-01 DOI: 10.1155/2020/3939718
Marina Näsman, Johan Niklasson, Jan Saarela, Mikael Nygård, Birgitta Olofsson, Yngve Gustafson, Fredrica Nyqvist
{"title":"Morale in Old Age and Its Association with Sociodemographic, Social, and Health-Related Factors in Different Age Groups.","authors":"Marina Näsman,&nbsp;Johan Niklasson,&nbsp;Jan Saarela,&nbsp;Mikael Nygård,&nbsp;Birgitta Olofsson,&nbsp;Yngve Gustafson,&nbsp;Fredrica Nyqvist","doi":"10.1155/2020/3939718","DOIUrl":"https://doi.org/10.1155/2020/3939718","url":null,"abstract":"<p><p>Morale can be viewed as a future-oriented optimism or pessimism regarding challenges associated with aging and is closely related to subjective well-being. Promoting morale in old age could be considered to have important implications for aging well, and increased knowledge about morale in different stages of old age is needed. Hence, the aim of this study was to investigate factors associated with morale in different age groups among old people. Data were derived from a survey conducted in 2016, as a part of the Gerontological Regional Database (GERDA). The sample consisted of 9,047 individuals aged between 65 and 86 years from Ostrobothnia and Southern Ostrobothnia in Finland, and Västerbotten in Sweden. Morale was measured with the Philadelphia Geriatric Center Morale Scale (PGCMS) and regressed upon a number of sociodemographic, social, and health-related factors using linear regression analyses. The results showed that older age was an independent factor explaining lower level of morale. Additionally, the sociodemographic, social, and health-related variables could explain a large proportion of the variance in morale. Perceived loneliness, having gone through a crisis in life, poor self-rated health, and depression were associated with lower morale, and sleeping well with higher morale, in all age groups. Furthermore, the oldest age groups seem to be more exposed to several risk factors of lower morale identified in this study. Multidimensional interventions targeting especially social and mental health and the oldest-old could therefore be recommended.</p>","PeriodicalId":14933,"journal":{"name":"Journal of Aging Research","volume":"2020 ","pages":"3939718"},"PeriodicalIF":4.7,"publicationDate":"2020-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2020/3939718","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38269453","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 10
Insulin-Like Growth Factor I Prevents Cellular Aging via Activation of Mitophagy. 胰岛素样生长因子I通过激活线粒体自噬阻止细胞衰老。
IF 4.7
Journal of Aging Research Pub Date : 2020-08-01 eCollection Date: 2020-01-01 DOI: 10.1155/2020/4939310
Xuwei Hou, Zhaohui Li, Yusuke Higashi, Patrice Delafontaine, Sergiy Sukhanov
{"title":"Insulin-Like Growth Factor I Prevents Cellular Aging via Activation of Mitophagy.","authors":"Xuwei Hou,&nbsp;Zhaohui Li,&nbsp;Yusuke Higashi,&nbsp;Patrice Delafontaine,&nbsp;Sergiy Sukhanov","doi":"10.1155/2020/4939310","DOIUrl":"https://doi.org/10.1155/2020/4939310","url":null,"abstract":"<p><p>Mitochondrial dysfunction is a hallmark of cellular aging. Mitophagy is a critical mitochondrial quality control mechanism that removes dysfunctional mitochondria and contributes to cell survival. Insulin-like growth factor 1 (IGF-1) promotes survival of smooth muscle cells (SMCs), but its potential effect on cellular aging is unknown yet. We found that IGF-1 decreased cell senescence, prevented DNA telomere shortening, increased mitochondrial membrane potential, activated cytochrome C oxidase, and reduced mitochondrial DNA damage in long-term cultured (aged) aortic SMC, suggesting an antiaging effect. IGF-1 increased mitophagy in aged cells, and this was associated with decreased expression of cyclin-dependent kinase inhibitors p16 and p21 and elevated levels of Nrf2 and Sirt3, regulators of mitophagy and mitochondrial biogenesis. SiRNA-induced inhibition of either Nrf2 or Sirt3 blocked IGF-1-induced upregulation of mitophagy, suggesting that the Nrf2/Sirt3 pathway was required for IGF-1's effect on mitophagy. PINK1 is a master regulator of mitophagy. PINK1 silencing suppressed mitophagy and inhibited IGF-1-induced antiaging effects in aged SMC, consistent with an essential role of mitophagy in IGF-1's effect on cellular aging. Thus, IGF-1 inhibited cellular aging via Nrf2/Sirt3-dependent activation of mitophagy. Our data suggest that activation of IGF-1 signaling is a novel potential strategy to activate mitophagy and slow cellular aging.</p>","PeriodicalId":14933,"journal":{"name":"Journal of Aging Research","volume":"2020 ","pages":"4939310"},"PeriodicalIF":4.7,"publicationDate":"2020-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2020/4939310","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38269454","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 13
Young and Older Adults Differ in Integration of Sensory Cues for Vertical Perception. 年轻人和老年人在垂直知觉的感官线索整合方面存在差异。
IF 4.7
Journal of Aging Research Pub Date : 2020-07-31 eCollection Date: 2020-01-01 DOI: 10.1155/2020/8284504
Rima Abdul Razzak, Jeff Bagust, Sharon Docherty
{"title":"Young and Older Adults Differ in Integration of Sensory Cues for Vertical Perception.","authors":"Rima Abdul Razzak,&nbsp;Jeff Bagust,&nbsp;Sharon Docherty","doi":"10.1155/2020/8284504","DOIUrl":"https://doi.org/10.1155/2020/8284504","url":null,"abstract":"<p><strong>Introduction: </strong>The subjective visual vertical (SVV) measures the perception of a person's spatial orientation relative to gravity. Weighted central integration of vestibular, visual, and proprioceptive inputs is essential for SVV perception. Without any visual references and minimal proprioceptive contribution, the static SVV reflects balance of the otolith organs. Normal aging is associated with bilateral and progressive decline in otolith organ function, but age-dependent effects on SVV are inconclusive. Studies on sensory reweighting for visual vertical and multisensory integration strategies reveal age-dependent differences, but most studies have included elderly participants in comparison to younger adults. The aim of this study was to compare young adults with older adults, an age group younger than the elderly.</p><p><strong>Methods: </strong>Thirty-three young and 28 older adults (50-65 years old) adjusted a tilted line accurately to their perceived vertical. The rod's final position from true vertical was recorded as tilt error in degrees. For otolithic balance, visual vertical was recorded in the dark without any visual references. The rod and frame task (RFT) with tilted disorienting visual frames was used for creating visuovestibular conflict. We adopted Nyborg's analysis method to derive the rod and frame effect (RFE) and trial-to-trial variability measures. Rod alignment times were also analyzed.</p><p><strong>Results: </strong>There was no age difference in signed tilts of SVV without visual reference. There was an age effect on RFE and on overall trial-to-trial variability of rod tilt, with older adults displaying larger frame effects and greater variability in rod tilts. Alignment times were longer in the tilted-frame conditions for both groups and in the older adults compared to their younger counterparts. The association between tilt accuracy and tilt precision was significant for older adults only during visuovestibular conflict, revealing an increase in RFE with an increase in tilt variability. Correlation of <i>σ</i> <sub>SVV</sub>, which represents vestibular input precision, with RFE yielded exactly the same contribution of <i>σ</i> <sub>SVV</sub> to the variance in RFE for both age groups.</p><p><strong>Conclusions: </strong>Older adults have balanced otolithic input in an upright position. Increased reliance on visual cues may begin at ages younger than what is considered elderly. Increased alignment times for older adults may create a broader time window for integration of relevant and irrelevant sensory information, thus enhancing their multisensory integration. In parallel with the elderly, older adults may differ from young adults in their integration of sensory cues for visual vertical perception.</p>","PeriodicalId":14933,"journal":{"name":"Journal of Aging Research","volume":"2020 ","pages":"8284504"},"PeriodicalIF":4.7,"publicationDate":"2020-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2020/8284504","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38269455","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 4
High Burden among Older Family Caregivers is Associated with High Prevalence of Symptoms: Data from the Swedish Study "Good Aging in Skåne (GÅS)". 老年家庭照顾者的高负担与症状的高患病率相关:来自瑞典研究“skamatne的良好衰老(GÅS)”的数据。
IF 4.7
Journal of Aging Research Pub Date : 2020-07-26 eCollection Date: 2020-01-01 DOI: 10.1155/2020/5272130
Henrik Ekström, Nathalie Lundholm Auoja, Sölve Elmståhl, Lena Sandin Wranker
{"title":"High Burden among Older Family Caregivers is Associated with High Prevalence of Symptoms: Data from the Swedish Study \"Good Aging in Skåne (GÅS)\".","authors":"Henrik Ekström,&nbsp;Nathalie Lundholm Auoja,&nbsp;Sölve Elmståhl,&nbsp;Lena Sandin Wranker","doi":"10.1155/2020/5272130","DOIUrl":"https://doi.org/10.1155/2020/5272130","url":null,"abstract":"<p><strong>Background/aim: </strong>Certain groups of informal caregivers have been shown to have worse health compared to noncaregivers. The aim of this cross-sectional study was to explore the health and gender aspects of caregiving in an older Swedish population.</p><p><strong>Methods: </strong>Our study included 5457 participants from the longitudinal, general population study \"Good Aging in Skåne.\" A total of 33 self-reported symptoms were obtained from questionnaires and were then divided into seven domains: depressive, musculoskeletal, gastrourinary, symptoms related to head, cardiopulmonary, symptoms related to tension, and metabolic symptoms. Multivariate logistic regression analysis was performed to assess the risk of developing symptoms in each of the seven domains, regarding caregiving burden and caregiving in relation to gender.</p><p><strong>Results: </strong>We found that caregivers, compared to noncaregivers, had a higher prevalence for depressive and tension-related symptoms. High-burden caregivers exhibited significantly more individual symptoms and a higher prevalence of symptoms in the depressive, tension, and gastrourinary domains of symptoms compared to both low-burden caregivers and noncaregivers. More than 79% of high-burden caregivers reported general fatigue, and over half of the high-burden caregivers experience depressive mood. Female caregivers showed a significantly higher risk of reporting depressive symptoms (OR = 1.54, 95% CI 1.19-1.98) and tension-related symptoms compared to male caregivers.</p><p><strong>Conclusion: </strong>Depressive and tension-related symptoms were more common in caregivers, especially in high-burden caregivers. High-burden caregivers might be at a risk of adverse mental health, and this highlights the need to offer proper support to these groups.</p>","PeriodicalId":14933,"journal":{"name":"Journal of Aging Research","volume":"2020 ","pages":"5272130"},"PeriodicalIF":4.7,"publicationDate":"2020-07-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2020/5272130","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38247840","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 11
Frailty and Nutritional Status among Urban Older Adults in South India. 印度南部城市老年人的虚弱和营养状况。
IF 4.7
Journal of Aging Research Pub Date : 2020-07-10 eCollection Date: 2020-01-01 DOI: 10.1155/2020/8763413
T Shalini, P Swathi Chitra, B Naveen Kumar, G Madhavi, G Bhanuprakash Reddy
{"title":"Frailty and Nutritional Status among Urban Older Adults in South India.","authors":"T Shalini,&nbsp;P Swathi Chitra,&nbsp;B Naveen Kumar,&nbsp;G Madhavi,&nbsp;G Bhanuprakash Reddy","doi":"10.1155/2020/8763413","DOIUrl":"https://doi.org/10.1155/2020/8763413","url":null,"abstract":"<p><p>The purpose of this study was to assess the prevalence of frailty and nutritional status among older adults. This population-based cross-sectional study was conducted in 163 subjects aged 60-88 years, from Hyderabad City, South India. Data were obtained on sociodemographic details and anthropometry and biochemical parameters. Dietary intake was assessed by a three-day 24 h dietary recall, and the probability of adequacy (PA) was calculated using the estimated average requirements. Frailty indicators were as follows: handgrip strength was measured by using a Jamar dynamometer, gait speed was measured by a ten-meter length walk test, and low physical activity level, weight loss, and exhaustion were assessed using a questionnaire. Among the study population, 20% of the participants were frail and 80% were nonfrail. The prevalence of frailty is higher in older (30.1%) than the younger (12.2%) age groups, and it is more so in women (32.4%) than in men (10.1%). The lower educational status and income were associated with frailty. The PA of most of the nutrients was low in the frail group. Noticeably, the mean PA (MPA) across the fourteen micronutrients was significantly higher in nonfrail (38%) compared to the frail group (25%). The prevalence of frailty was higher in the lowest tertile of most of the food groups and nutrient intake compared to the highest tertile. The study revealed a 20% prevalence of frailty among urban older adults and provided evidence that inadequate intake of nutrients is independently associated with frailty.</p>","PeriodicalId":14933,"journal":{"name":"Journal of Aging Research","volume":"2020 ","pages":"8763413"},"PeriodicalIF":4.7,"publicationDate":"2020-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2020/8763413","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38178372","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 13
Physical Frailty and Fall Risk in Community-Dwelling Older Adults: A Cross-Sectional Study. 社区居住的老年人身体虚弱和跌倒风险:一项横断面研究。
IF 4.7
Journal of Aging Research Pub Date : 2020-07-04 eCollection Date: 2020-01-01 DOI: 10.1155/2020/3964973
Jiraporn Chittrakul, Penprapa Siviroj, Somporn Sungkarat, Ratana Sapbamrer
{"title":"Physical Frailty and Fall Risk in Community-Dwelling Older Adults: A Cross-Sectional Study.","authors":"Jiraporn Chittrakul,&nbsp;Penprapa Siviroj,&nbsp;Somporn Sungkarat,&nbsp;Ratana Sapbamrer","doi":"10.1155/2020/3964973","DOIUrl":"https://doi.org/10.1155/2020/3964973","url":null,"abstract":"<p><strong>Introduction: </strong>Frailty is a condition in older adults with decreased physical and cognitive performance that can affect health outcomes associated with fracture, disability, and falls. The aim of this study was to compare fall risk with different physical frailty statuses and investigate factors associated with fall risk in community-dwelling older adults.</p><p><strong>Methods: </strong>The population studied included 367 older adults (mean age = 73.2 years ± 7.0; 237 females (64.6%) and 130 males (35.4%)) who live in Chiang Mai, Thailand. This study was of cross-sectional design. Fried's phenotype was used to screen the physical frailty status. The physiological profile assessment (PPA) was used to screen for fall risk. One-way ANOVA analysis was used to compare the fall risk between the different levels of frailty status. Linear regression analysis was used to assess the association between frailty status and fall risk.</p><p><strong>Results: </strong>The prevalence of the frailty group was 8.7% and that of the prefrailty group was 76.8%. The three statuses of frailty identified were found to have different levels of risk of falling. The frailty group had a higher fall risk than the nonfrailty group and the prefrailty group. In addition, the nonfrailty group had a lower fall risk than the prefrailty group.</p><p><strong>Conclusion: </strong>The frailty group had the highest fall risk in this cohort of older adults living in a community-dwelling facility. Therefore, it is important to assess the frailty status among older adults as it can be a predictor for fall risk. This assessment will therefore lead to a reduction in the rate of disability and death in the community.</p>","PeriodicalId":14933,"journal":{"name":"Journal of Aging Research","volume":"2020 ","pages":"3964973"},"PeriodicalIF":4.7,"publicationDate":"2020-07-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2020/3964973","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38194157","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 22
Frailty and the Risk of Polypharmacy in the Older Person: Enabling and Preventative Approaches. 老年人的虚弱和多重用药的风险:支持和预防方法。
IF 4.7
Journal of Aging Research Pub Date : 2020-06-29 eCollection Date: 2020-01-01 DOI: 10.1155/2020/6759521
Martin C Nwadiugwu
{"title":"Frailty and the Risk of Polypharmacy in the Older Person: Enabling and Preventative Approaches.","authors":"Martin C Nwadiugwu","doi":"10.1155/2020/6759521","DOIUrl":"https://doi.org/10.1155/2020/6759521","url":null,"abstract":"<p><p>Frail older people have an inherent risk of polypharmacy due to the need to treat multiple comorbidities, thus leading to various negative effects on their health due to the adverse actions from the drugs. This issue was discussed from a person-centered perspective, highlighting the category of frail older adults who are at a higher risk. Appropriate medication reconciliation in this population with useful prescribing tools (Beers and START/STOPP criteria) to minimize polypharmacy and to provide alternative prescriptive intervention could go alongside primary care to reduce the extent of frailty and polypharmacy. Reducing delayed referrals and extended hospitalization with electronic health record systems and using the signs of frailty from the Electronic Frailty Index (EFI) to predict polypharmacy for frail older persons are preventative approaches that proactively respond to frailty associated with the risk of polypharmacy.</p>","PeriodicalId":14933,"journal":{"name":"Journal of Aging Research","volume":"2020 ","pages":"6759521"},"PeriodicalIF":4.7,"publicationDate":"2020-06-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2020/6759521","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38161949","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 27
Clinical Conditions of Hospitalized Older Adult Patients and Their Outcomes in a Regional Referral Hospital in Southwestern Uganda. 乌干达西南部一家地区转诊医院住院老年患者的临床状况及其结果
IF 4.7
Journal of Aging Research Pub Date : 2020-06-29 eCollection Date: 2020-01-01 DOI: 10.1155/2020/6830495
Patrick Orikiriza, Godfrey Z Rukundo, Adrian Kayanja, Joel Bazira
{"title":"Clinical Conditions of Hospitalized Older Adult Patients and Their Outcomes in a Regional Referral Hospital in Southwestern Uganda.","authors":"Patrick Orikiriza,&nbsp;Godfrey Z Rukundo,&nbsp;Adrian Kayanja,&nbsp;Joel Bazira","doi":"10.1155/2020/6830495","DOIUrl":"https://doi.org/10.1155/2020/6830495","url":null,"abstract":"<p><strong>Background: </strong>Recent advances in medicine have caused positive impact on the life expectancy of most countries, resulting in increased older adult population. Aging comes with a number of health challenges. This study investigated health conditions of older adults at admission and clinical outcomes in a regional referral hospital in southwestern Uganda.</p><p><strong>Methods: </strong>A retrospective study reviewed clinical data of older adult patients admitted between January 2016 and December 2017. Demographic data, cause of admission, length, and outcomes of hospitalization are described.</p><p><strong>Results: </strong>Up to 813 patient files were reviewed. The patients had been hospitalized to emergency, 371 (45.6%); medical, 355 (43.7%); surgical, 84 (10.3%); psychiatry, 2 (0.3%); and obstetrics and gynecology, 1 (0.1%) wards. The majority, 427 (52.5%), of the patients were females. Cancer was the most common reason for hospitalization, 130/889 (14.6%), followed by stroke, 94/889 (10.6%); heart failure, 76/889 (8.6%); chronic obstructive pulmonary disease, 56/889 (6.3%); pneumonia, 47/889 (5.3%); and head injury, 45/889 (5.1%), whilst 560 (68.9%) of the hospitalized patients were discharged, 197 (24.2%) died, 18 (2.2%) were referred for advanced care, and 38 (4.7%) escaped from the facility. The emergency ward had the highest deaths, 101 (51.3%), then medical, 56 (28.4%), and surgical, 39 (19.8%), wards. Mortality of those who died was admitted with stroke, 30 (15.2%), cancer, 21 (10.7%), head injury, 16 (8.1%), heart failure, 14 (7.1%), sepsis, 14 (7.1%), and renal disease, 12 (6.1%). On average, patients were admitted for 5 days (IQR: 3-8).</p><p><strong>Conclusions: </strong>The high proportion of mortality in this group is worrying and requires further investigations.</p>","PeriodicalId":14933,"journal":{"name":"Journal of Aging Research","volume":"2020 ","pages":"6830495"},"PeriodicalIF":4.7,"publicationDate":"2020-06-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2020/6830495","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38161950","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 4
A Qualitative Study of Nursing Students' Experiences in Fall Prevention for Older Home Care Clients. 护生在家照顾长者预防跌倒经验的质性研究。
IF 4.7
Journal of Aging Research Pub Date : 2020-06-28 eCollection Date: 2020-01-01 DOI: 10.1155/2020/7652623
Riitta Turjamaa, Marja Äijö, Tarja Tervo-Heikkinen, Marja Silén-Lipponen
{"title":"A Qualitative Study of Nursing Students' Experiences in Fall Prevention for Older Home Care Clients.","authors":"Riitta Turjamaa,&nbsp;Marja Äijö,&nbsp;Tarja Tervo-Heikkinen,&nbsp;Marja Silén-Lipponen","doi":"10.1155/2020/7652623","DOIUrl":"https://doi.org/10.1155/2020/7652623","url":null,"abstract":"<p><p>The aim of this study was to describe the experiences of nursing students in fall prevention during clinical practice in the context of older home care clients. This was a qualitative focus group study of nursing students (<i>n</i> = 9) who had completed clinical practice in older clients' home care. The data were analysed using inductive content analysis. The nursing students described their experiences regarding falls and fall prevention in older clients' home care from two perspectives: evaluation of falls at older people's homes and fall prevention during home visits. Systematic evaluation of falls was based on physical examination and is the basis of fall prevention. However, evaluation of nutrition and adverse drug effects seemed to be ignored. In addition, fall prevention during home visits included concrete fall prevention in authentic client situations, confidential relationships with older clients, and evidence-based knowledge. From the perspective of fall prevention, there was a lack of comprehensive evaluation and understanding of the meaning of psychological factors, such as fear of falling. In order to be able to prevent falls in the older client population, students need more guidance regarding a comprehensive approach based on evaluation of falls. In addition, there is a need for continuous collaboration between education and home care services to develop educational approaches that interlink knowledge and skills in fall prevention.</p>","PeriodicalId":14933,"journal":{"name":"Journal of Aging Research","volume":"2020 ","pages":"7652623"},"PeriodicalIF":4.7,"publicationDate":"2020-06-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2020/7652623","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38161951","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 3
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