Journal of Aging Research最新文献

{"title":"Exercise Improves Cardiac Dysfunction in D-Galactose-Treated Rats by Regulation of IGF-1-Humanin Pathway.","authors":"Hesam Askarimoghadam, Farzaneh Rostamzadeh, Maryamossadat Mirtajaddini Goki, Elham Jafari, Mahboobeh Yeganeh-Hajahmadi","doi":"10.1155/jare/9949234","DOIUrl":"10.1155/jare/9949234","url":null,"abstract":"<p><p><b>Introduction:</b> Humanin, a mitochondrial-derived peptide, decreases in the elderly. This study evaluated the effects of concurrent moderate-intensity endurance training (MIET) or high-intensity interval training (HIIT) with D-galactose injection on cardiac function, and the serum and heart levels of humanin and IGF-1 in Wistar male rats. <b>Methods:</b> Left ventricular systolic pressure (LVSP), left ventricular end diastolic pressure (LVEDP), ±maxdp/dt, contractility index (CI) and, Tau were monitored by PowerLab system in CTL, CTL + MIET, CTL + HIIT, D-gal, D-gal + MIET, and D-gal + HIIT groups. The histopathological score, fibrosis, and humanin and IGF-1 levels were measured with hematoxylin & eosin, Masson's trichrome, and enzyme-linked immunosorbent assay, respectively. <b>Results:</b> Histopathological score and heart fibrosis were reduced by HIIT and MIET in the D-gal group. LVSP, ±maxdp/dt, and CI were lower, while LVEDP and Tau were higher in the D-gal group than in the CTL group. MIET and HIIT alleviated the changes in LVSP, ±maxdp/dt, CI, LVEDP, and Tau. HIIT and MIET increased humanin levels in heart and serum of the D-gal group by modifying IGF-1 levels. <b>Conclusion:</b> The study suggests HIIT and MIET may improve cardiac function by regulating the IGF-1-humanin signaling pathway.</p>","PeriodicalId":14933,"journal":{"name":"Journal of Aging Research","volume":"2025 ","pages":"9949234"},"PeriodicalIF":2.1,"publicationDate":"2025-09-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12496137/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145232897","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Variation in the Content of Three Tandem Repeats of the Human Genome (Ribosomal, Satellite III, and Telomere) in Peripheral Blood Leukocyte DNA of People of Different Ages (5-101 Years).","authors":"E S Ershova, P E Umriukhin, R A Zinchenko, T P Vasilieva, S E Kostyuk, N Yu Shabalin, T A Salimova, E M Malinovskaya, N N Veiko, S V Kostyuk","doi":"10.1155/jare/8847073","DOIUrl":"10.1155/jare/8847073","url":null,"abstract":"<p><p>The variation of ribosomal (parameter <b>R</b>), satellite III (1q12) (parameter <b>S</b>), and telomere (parameter <b>T</b>) tandem repeats content of the human genome was studied in DNA samples isolated from blood leukocytes of 535 people whose age varied from 5 to 101 years. For analysis we used the method of nonradioactive quantitative hybridization. The group of centenarians (90-101 years old, <i>N</i> = 106) differs from other age groups by a significantly narrower distribution of the ribosomal repeat content in DNA, a much higher content of satellite III, and a lower content of telomere repeat. A negative correlation was found between the <b>S</b> and <b>T</b> parameters (<i>p</i> < 10^-4). The findings of this study suggest that the calculated parameters <b>S/T</b> and <b>S/(R∗T)</b> exhibit a marked increase with age, culminating in maximal values within the cohort of centenarians. These results imply that the parameters <b>R</b>, <b>S/T</b>, and <b>S/(R∗T)</b> may hold the potential to serve as reliable predictors of life expectancy for individuals in advanced age.</p>","PeriodicalId":14933,"journal":{"name":"Journal of Aging Research","volume":"2025 ","pages":"8847073"},"PeriodicalIF":2.1,"publicationDate":"2025-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12446595/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145113411","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Enhancing Cognitive Health in Elderly Individuals: The Impact of Hatha Yoga on Attention, Memory, and Reasoning: A Randomized Controlled Trial.","authors":"Rania Oueslati, Mohamed Abdelkader Souissi, Sana Jarraya, Fatma Hilal Yagin, Georgian Badicu, Fahaid Al-Hashem, Luca Paolo Ardigò, Riadh Dahmen","doi":"10.1155/jare/9990963","DOIUrl":"10.1155/jare/9990963","url":null,"abstract":"<p><p><b>Background:</b> Aging leads to physiological and psychological changes that compromise both mental and physical autonomy, as well as cognitive functions, thereby increasing the risk of anxiety and depression. The sedentary lifestyle typical of older individuals results in a deterioration of the overall quality of life and well-being. <b>Objective:</b> This study aims to evaluate the effectiveness of Hatha yoga in improving cognitive health among older adults. We will specifically examine the impact of this practice on attention, memory, and reasoning. <b>Methods:</b> The present study assesses the impact of Hatha yoga on attention, memorization, and reasoning in healthy older adults aged between 65 and 80 years. The study population comprises 45 healthy individuals (26 men and 19 women; 72.3 ± 5.6 years) residing in a retirement home, divided into three groups: a yoga group (YOGA, <i>n</i> = 15) that participated in yoga sessions; a physical activity group (APS, <i>n</i> = 15) engaged in sports and physical activities sessions; and a control group (CONT, <i>n</i> = 15) that did not undertake any activities. The study spanned 24 sessions, with two sessions per week lasting 45 min each. Participants completed test sessions dedicated to evaluating attention, memory, and reasoning before (T0) and after (T1) 12 weeks. A two-way ANOVA was used to analyze the differences between groups and over time. <b>Results:</b> After the intervention sessions, the data showed that the YOGA group registered significantly greater improvements at T1 compared to that of T0 in all cognitive parameters (e.g., attention (<i>p</i> < 0.001, Hedges' <i>g</i> = 1.35), memory (<i>p</i> < 0.001, Hedges' <i>g</i> = 1.04), and reasoning (<i>p</i> < 0.001, Hedges' <i>g</i> = 1.82)). Furthermore, our results revealed a significant difference between the YOGA group and both the APS (<i>p</i> < 0.001) and CONT (<i>p</i> < 0.01) groups for the attention and reasoning parameters at T1. <b>Conclusions:</b> This study underscores the potential of Hatha yoga to enhance the mental well-being of the elderly, suggesting significant benefits for cognitive well-being in this population. <b>Trial Registration:</b> Pan African Clinical Trials Registry: PACTR202405804830163.</p>","PeriodicalId":14933,"journal":{"name":"Journal of Aging Research","volume":"2025 ","pages":"9990963"},"PeriodicalIF":2.1,"publicationDate":"2025-09-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12436006/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145075321","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Examining the Cognitive Underpinnings of Functional Decline in Prodromal Alzheimer's Disease: Insights From the Details of Functions of Everyday Life (DoFEL) Scale.","authors":"Freddie O'Donald, Clara Calia, Mario A Parra","doi":"10.1155/jare/2610700","DOIUrl":"10.1155/jare/2610700","url":null,"abstract":"<p><p>Available assessments for early-stage Alzheimer's disease (AD) identify neuropsychological and functional impairments, which rarely correlate in the early disease stages. The ability to bind information in memory declines in preclinical AD stages. However, it is unclear whether such cognitive deficits underlie functional impairment in prodromal AD stages. This study investigates whether incorporating memory binding, a function that is a sensitive cognitive marker for early-stage AD, into a functional assessment tool can reveal the cognitive underpinnings of daily activities. The Details of Function of Everyday Life (DoFEL) scale was revised, and its latent structure was explored through principal axis factoring in a nonclinical sample (<i>n</i> = 559). Dementia professionals subsequently reviewed the revised DoFEL for content validity, followed by confirmatory factor analysis in another nonclinical sample (<i>n</i> = 135). Additionally, 49 participants with mild cognitive impairment (MCI) and 33 healthy controls completed the DoFEL, Addenbrooke's Cognitive Examination-Revised (ACE-R) and a Visual Short-Term Memory Binding Task (VSTMBT). Correlation analysis and binomial regression were used to examine the relationship between DoFEL scores and cognitive measures and to assess its ability to differentiate between healthy controls and MCI patients. The revised DoFEL showed satisfactory structural and construct validity, although some items lacked content validity. Significant negative associations were found between DoFEL scores and ACE-R (<i>r</i> = -0.66, <i>p</i> < 0.001) as well as VSTMBT (<i>r</i> = -0.52, <i>p</i>=0.003) performances. Binomial regression demonstrated the DoFEL's effectiveness in distinguishing healthy controls from MCI patients (AUC = 0.95). These findings suggest that linking memory binding with functional performance could enhance functional assessment in early-stage AD.</p>","PeriodicalId":14933,"journal":{"name":"Journal of Aging Research","volume":"2025 ","pages":"2610700"},"PeriodicalIF":2.1,"publicationDate":"2025-08-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12364600/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144955052","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Arabic Adaptation and Validation of the SARC-F Questionnaire for Sarcopenia Screening in Elderly Populations: Exploration of Associated Factors.","authors":"Hadeel M Badwan, Ziad Hawamdeh, Mohamed I Mabrouk, Mohamed I Kamel, Alia A Alghwiri","doi":"10.1155/jare/7405872","DOIUrl":"10.1155/jare/7405872","url":null,"abstract":"<p><p><b>Background:</b> Sarcopenia is a geriatric condition marked by decreased muscle mass and function as people age. The SARC-F questionnaire is a simple and useful instrument for sarcopenia screening but it is not available in the Arabic language. This study aimed to translate the SARC-F into the Arabic language, validate it among Arabic-speaking older adults, and explore the association between SARC-F and fatigue, QOL, and cognitive impairment. <b>Methods:</b> SARC-F was translated into Arabic according to WHO guidelines, and older adults aged 60 years and older were recruited. Test-retest reliability of SARC-F was examined over a 2-week period. SARC-F was validated based on the revised European Working Group on Sarcopenia in Older People criteria. Sensitivity, specificity, and positive and negative predictive values were assessed against bioelectrical impedance analysis (BIA). The association between the Arabic SARC-F and Modified Fatigue Impact Scale, Medical Outcomes Study Short Form 12, and Montreal Cognitive Assessment was investigated too. <b>Results:</b> Eighty-six older adults participated in this study (59.3% females). The Arabic SARC-F showed an intraclass correlation coefficient (ICC) of 0.926 (95% CI = 0.88-0.95) and Cronbach's alpha of 0.81. Sensitivity, specificity, and positive predictive value and negative predictive value were 36.4%, 78.7%, 20%, and 89.3%, respectively. The Arabic version of SARC-F showed good reliability and validity. <b>Conclusion:</b> The Arabic SARC-F is a valid and reliable tool for sarcopenia screening, showing a good ability to identify individuals with sarcopenia and predict the absence of the condition. The Arabic SARC-F was associated with fatigue and QOL but not with cognitive impairment. These results support the use of the Arabic SARC-F as a useful questionnaire for sarcopenia screening in Arabic-speaking populations.</p>","PeriodicalId":14933,"journal":{"name":"Journal of Aging Research","volume":"2025 ","pages":"7405872"},"PeriodicalIF":2.1,"publicationDate":"2025-08-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12356668/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144873304","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Combined Exercise and Ursolic Acid Improve Hippocampal Neuronal Markers and Exploratory-Locomotor Behavior in Aged Diabetic Rats.","authors":"Safoura Alizade, Abbas Ali Gaeini, Mohammad Faramarzi","doi":"10.1155/jare/9916781","DOIUrl":"10.1155/jare/9916781","url":null,"abstract":"<p><p><b>Background:</b> Diabetes mellitus is linked to progressive cognitive decline and motor impairments, especially among the aging population, highlighting the importance of early detection through reliable neuronal biomarkers. Proteins such as neurofilament light chain (NFL), neurogranin (Ng), and visinin-like protein 1 (VILIP-1) have emerged as indicators of neurodegeneration and associated behavioral changes. This study examined the effects of combined endurance and resistance exercise, along with ursolic acid (UA) supplementation, on hippocampal neuronal biomarkers and exploratory-locomotor behavior in aged diabetic rats. <b>Methods:</b> In this experiment, 21-month-old male Wistar rats were assigned to seven groups. Diabetes was induced using a single intraperitoneal dose of streptozotocin (STZ) (30 mg/kg) in combination with a high-fat diet (55% fat, 31% carbohydrate, and 14% protein). Interventions included endurance training (60%-75% vVO_2max), resistance training (60% MVCC), and daily oral UA administration (250 mg/kg) over eight weeks. Neuronal biomarkers (NFL, Ng, and VILIP-1) were measured in hippocampal tissue via western blot, and exploratory and locomotor behavior was assessed using the open-field test. <b>Results:</b> The results showed that UA supplementation combined with resistance training significantly reduced the levels of neuronal biomarkers NFL (<i>p</i> < 0.001), Ng (<i>p</i> < 0.01), and VILIP-1 (<i>p</i> < 0.001) in diabetic rats compared to untreated diabetic controls. <b>Conclusion:</b> The study demonstrated that diabetes leads to a marked elevation in NFL, Ng, and VILIP-1 protein levels, while a combined intervention of exercise and UA mitigated neurodegenerative changes and improved exploratory-locomotor outcomes.</p>","PeriodicalId":14933,"journal":{"name":"Journal of Aging Research","volume":"2025 ","pages":"9916781"},"PeriodicalIF":2.1,"publicationDate":"2025-08-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12339154/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144821493","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Searching for a Potential Blue Zone in the Nordics: A Study on Differences in Lifestyle and Health in Regions Varying in Longevity in Western Finland.","authors":"Sarah Åkerman, Dorly Deeg, Erika Boman, Johan Niklasson, Yngve Gustafson, Fredrica Nyqvist","doi":"10.1155/jare/5535904","DOIUrl":"10.1155/jare/5535904","url":null,"abstract":"<p><p>To delay social and healthcare utilisation among the ageing population, there is an increasing focus on the role of health-promoting lifestyle adopted at an individual and/or community level. Longevity is generally viewed as the ultimate outcome of health, although a high life expectancy does not necessarily go together with health and/or a health-promoting lifestyle. The potential coherence between longevity, health and lifestyle may vary in different cultural, political, social and economic contexts. This Nordic regional study situated in regions differing in longevity aims to (i) explore differences in adherence to the comprehensive, health-promoting Blue Zone lifestyle principles in four regions in Western Finland (bilingual Ostrobothnia, Swedish-speaking Åland and Finnish-speaking South Ostrobothnia) and (ii) investigate regional differences in health. Thus, the present study aims to examine if adherence to Blue Zone lifestyle principles and good health is highest in the most longevous region. Survey data from the Gerontological Regional Database in 2021-2022 were used. Marginal means were calculated using ANOVA. The results showed that Åland, Finland's most longevous region, showed the best health and higher environmental agreeableness, while deviated from several Blue Zone lifestyle principles. Swedish-speaking Ostrobothnia showed good health and adherence to the Blue Zone lifestyle. South Ostrobothnia showed the poorest health but as much adherence to the Blue Zone lifestyle as Swedish-speaking Ostrobothnia. Finnish-speaking Ostrobothnia deviated the most from the Blue Zone lifestyle. The findings imply that Nordic longevous regions do not necessarily adhere to the Blue Zone lifestyle. Future research incorporating individual, community and societal factors could further elucidate whether and how longevity, lifestyle and health are interconnected in different ethnolinguistic contexts to further advance the understanding of healthy ageing and improve the implementation of effective health-promoting initiatives.</p>","PeriodicalId":14933,"journal":{"name":"Journal of Aging Research","volume":"2025 ","pages":"5535904"},"PeriodicalIF":2.1,"publicationDate":"2025-08-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12335905/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144816717","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of the Effectiveness of Transcranial Direct Current Stimulation (tDCS) and Short-Term Cognitive Rehabilitation Protocols on the Improvement of Depression and Anxiety Symptoms in Patients With Mild Alzheimer's Disease.","authors":"Arezoo Mojarrad, Esmaeil Sadri Damirchi, Ali Sheykholeslami, Ali Rezaeisharif, Vahid Abbasi, Mohammadreza Noroozi Homayoon","doi":"10.1155/jare/6616509","DOIUrl":"10.1155/jare/6616509","url":null,"abstract":"<p><p><b>Aim:</b> Today, Alzheimer's disease is one of the most common diseases, especially in old age, and it is important to help recognize and treat this disease. The purpose of this study was to compare the effectiveness of transcranial direct current stimulation (tDCS) and short-term cognitive rehabilitation protocols on the improvement of depression and anxiety symptoms in patients with mild Alzheimer's disease. <b>Methods:</b> The research method was an extended experiment with two experimental groups and one control group. The statistical population included all patients over 65 years of age with mild Alzheimer's who had been referred to a neurologist in 2020, and among these people, 60 people were selected through available sampling and then randomly assigned to two experimental groups and one control group. Then, the independent variables of the tDCS method for 10 sessions of 20 min once a week were applied to an experimental group and a short-term cognitive rehabilitation program of 9 sessions (90 min each session) was applied once a week to the second experimental group, and no intervention was performed on the third group. After the end of the intervention, the post-test was conducted with an interval of 1 week on the experimental and control groups. After 1 month, the studied groups were followed up again. A neuropsychological questionnaire (NPI) was used to collect information. <b>Results:</b> The results showed that both studied methods caused a significant reduction in depression in both the post-test and follow-up periods, but only the tDCS method was able to maintain its reduction in the follow-up period. Also, both methods have caused a significant improvement in the anxiety variable both during the post-test and during the follow-up period. <b>Conclusion:</b> Therefore, it can be concluded that both methods can be used to improve the symptoms of depression and anxiety in patients with mild Alzheimer's disease.</p>","PeriodicalId":14933,"journal":{"name":"Journal of Aging Research","volume":"2025 ","pages":"6616509"},"PeriodicalIF":2.1,"publicationDate":"2025-07-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12324912/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144789219","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Social and Activity Participation and Subjective Well-Being Among Older Adults in Japan: A Comparative Analysis of Healthy and Care-Needing Groups.","authors":"Jianyu Huang, Ziyan Wang, Richard Ssempala","doi":"10.1155/jare/5990506","DOIUrl":"10.1155/jare/5990506","url":null,"abstract":"<p><p><b>Objectives:</b> This study explores the relationship between social and activity participation (SAP) and subjective well-being (SWB) among older adults in Japan, with a particular focus on differences by care-needing status. <b>Methods:</b> Data were drawn from the 2019 Sakai City Older Adults Survey, including 5469 healthy and 406 care-needing individuals aged 65 and over (65.59% female). An ordered probit model was used to estimate the association between SAP and SWB, which was measured on an 11-point scale and categorized into three levels. To address potential endogeneity, instrumental variable (IV) analysis was conducted using information source diversity and health consciousness as instruments. <b>Results:</b> Higher frequency of SAP was positively associated with SWB among both healthy and care-needing older adults. While the association was stronger and more consistent among the healthy group, IV analysis revealed a statistically significant and robust relationship among care-needing individuals as well. The findings suggest that even older adults facing physical or cognitive limitations may experience psychological benefits from SAP. <b>Conclusions:</b> SAP is associated with better SWB among older adults, including those with care-needing status. These results support the promotion of inclusive community-based programs to enhance psychosocial health in aging populations.</p>","PeriodicalId":14933,"journal":{"name":"Journal of Aging Research","volume":"2025 ","pages":"5990506"},"PeriodicalIF":2.1,"publicationDate":"2025-07-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12321413/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144784279","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bowel Health, Laxative Use, and Cognitive Function in Older Puerto Rican Adults.","authors":"Deepika Dinesh, Jong Soo Lee, Tammy M Scott, Katherine L Tucker, Natalia Palacios","doi":"10.1155/jare/2674457","DOIUrl":"10.1155/jare/2674457","url":null,"abstract":"<p><p><b>Objectives:</b> Bowel dysfunction and habitual laxative use are indicators of poor gastrointestinal (GI) health and are inversely associated with cognitive function. These associations are understudied in Latino and Hispanic populations. Therefore, we examined the associations between bowel frequency, stool type, laxative use, and cognitive function in the Boston Puerto Rican Health Study (BPRHS). <b>Methods:</b> The BPRHS is a prospective cohort that enrolled 1502 Puerto Rican adults residing in the Boston Area, aged 45-75 years at baseline, with four waves of collection across 13 years. Cognitive function was measured using a composite global cognitive score (GCS) with low scores indicating worse cognitive function. Bowel health at Wave 4 was assessed by self-reported bowel frequency (times/day) and stool type. Self-reported laxative use (yes/no) was assessed at baseline and Wave 4. Adjusting for relevant covariates, we examined cross-sectional association between bowel frequency, stool type and GCS at Wave 4, and serial cross-sectional associations between laxative use and GCS at baseline and Wave 4. We used linear mixed models to examine time-varying laxative use and GCS over 13 years of follow-up. <b>Results:</b> At Wave 4, 155 (27.1%), 235 (41.0%), and 183 (31.9%) participants self-reported normal, low, and high bowel frequency, respectively, and 334 (65.9%), 72 (14.2%), and 101(19.9%) self-reported normal, hard, and loose stool type, respectively. At Wave 4, participants with high bowel frequency had low GCS (<i>β</i> = -0.152, <i>p</i>=0.02), but stool type was not associated with GCS. Self-reported laxative use increased from 6.8% (baseline) to 18.4% (Wave 4). Laxative users had low GCS at baseline (<i>β</i> = -0.13, <i>p</i>=0.01) and Wave 4 (<i>β</i> = -0.13, <i>p</i>=0.05). However, laxative use was not associated with a change in GCS over 13 years of follow-up (laxative use∗time <i>β</i> = 0.006, <i>p</i>=0.28). <b>Conclusion:</b> Low or high bowel frequency and laxative use may be inversely associated with cognitive function. Our results suggest a relationship between bowel and cognitive health. <b>Trial Registration:</b> ClinicalTrials.gov identifier: NCT01231958.</p>","PeriodicalId":14933,"journal":{"name":"Journal of Aging Research","volume":"2025 ","pages":"2674457"},"PeriodicalIF":2.1,"publicationDate":"2025-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12313385/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144760100","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}