Journal of Aging Research最新文献

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Exploring the Interplay Between Senescent Osteocytes and Bone Remodeling in Young Rodents. 探索衰老骨细胞与年轻啮齿动物骨重塑之间的相互作用
IF 1.6
Journal of Aging Research Pub Date : 2024-11-16 eCollection Date: 2024-01-01 DOI: 10.1155/2024/4213141
Insun Song, Pil-Jong Kim, Yong Jun Choi, Yoon-Sok Chung, Soonchul Lee, Jeong-Hwa Baek, Kyung Mi Woo
{"title":"Exploring the Interplay Between Senescent Osteocytes and Bone Remodeling in Young Rodents.","authors":"Insun Song, Pil-Jong Kim, Yong Jun Choi, Yoon-Sok Chung, Soonchul Lee, Jeong-Hwa Baek, Kyung Mi Woo","doi":"10.1155/2024/4213141","DOIUrl":"10.1155/2024/4213141","url":null,"abstract":"<p><p>This study identifies senescent osteocytes in the femur and tibia of young rodents and explores their role in bone remodeling. The proximity of osteoclasts to senescent osteocytes was observed, which is a new finding. Cultured osteocytes, sorted using a podoplanin antibody in FACS, exhibited osteocytic characteristics and increased senescence-related genes. Senescent osteocytes secreted cytokines associated with senescence, remodeling, and inflammation. Notably, IGF1 and MMP2 were elevated in podoplanin-positive (pdpn<sup>+</sup>) osteocytes. Migration assays demonstrated significant osteoclast precursor migration towards senescent osteocytes, further confirmed by co-culture experiments leading to osteoclast differentiation. These findings suggest that senescent osteocytes have a pivotal role in initiating bone resorption, with recruitment of osteoclast precursors during early bone remodeling stages. In conclusion, our research enhances our understanding of complicated bone remodeling mechanisms and bone homeostasis.</p>","PeriodicalId":14933,"journal":{"name":"Journal of Aging Research","volume":"2024 ","pages":"4213141"},"PeriodicalIF":1.6,"publicationDate":"2024-11-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11585373/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142710243","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Exploring Changes in Barriers and Facilitators for Physical Activity during the Retirement Transition: A Qualitative Interview Study Based on the Behavior Change Wheel. 探索退休过渡期体育活动障碍和促进因素的变化:基于行为改变轮的定性访谈研究。
IF 1.6
Journal of Aging Research Pub Date : 2024-09-16 eCollection Date: 2024-01-01 DOI: 10.1155/2024/3257287
Nina Vansweevelt, Jannique van Uffelen, Filip Boen, Jan Seghers
{"title":"Exploring Changes in Barriers and Facilitators for Physical Activity during the Retirement Transition: A Qualitative Interview Study Based on the Behavior Change Wheel.","authors":"Nina Vansweevelt, Jannique van Uffelen, Filip Boen, Jan Seghers","doi":"10.1155/2024/3257287","DOIUrl":"10.1155/2024/3257287","url":null,"abstract":"<p><p>The retirement transition has been associated with a decrease in total physical activity (PA). However, little is known about effective interventions to counteract this decrease. Prior to designing interventions, more information is needed about the changes in PA and in determinants of PA around this life change. Therefore, the first aim of this study was to investigate perceived changes in PA. The second aim was to explore the changes in PA barriers and facilitators experienced by recent retirees. Semistructured interviews were conducted with 30 retirees six to ten months after their retirement transition. The interview guide consisted of open questions as well as specific questions based on the \"behavior change wheel\" (BCW). The analysis of the interviews involved an initial inductive reflexive thematic analysis, followed by deductive mapping of the themes onto the COM-B categories, which are an integral part of the BCW. Most retirees experienced an increase in PA. The first inductive theme regarding changes in barriers and facilitators for PA was labelled as \"changes in time availability and time structure.\" For instance, one of the facilitators was that increased time availability led to more PA. However, as a barrier, it was noted that this sometimes resulted in increased procrastination as well. The second theme was labelled \"emotional/mental changes\" and included facilitators such as a decreased feeling of being useful with consequent uptake of new purposeful (physical) activities. Conversely, a perceived barrier was the idea that reduced PA is allowed after retirement. The third theme, \"social changes,\" highlights for instance the facilitator that many participants expressed an increased desire to expand their social network for shared (physical) activities. The identified themes were mapped onto the COM-B categories and potential intervention functions were discussed.</p>","PeriodicalId":14933,"journal":{"name":"Journal of Aging Research","volume":"2024 ","pages":"3257287"},"PeriodicalIF":1.6,"publicationDate":"2024-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11419837/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142307802","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Nurses' Perspectives and Understanding of Sarcopenia in a Tertiary Care Hospital. 一家三甲医院护士对 "肌肉疏松症 "的看法和理解。
IF 1.6
Journal of Aging Research Pub Date : 2024-09-12 eCollection Date: 2024-01-01 DOI: 10.1155/2024/9106500
Kanjana Khuankaew, Panita Limpawattana, Manchumad Manjavong, Nutwara Saengwijit, Khanyanut Ojongpien, Prapassawan Tanlawan
{"title":"Nurses' Perspectives and Understanding of Sarcopenia in a Tertiary Care Hospital.","authors":"Kanjana Khuankaew, Panita Limpawattana, Manchumad Manjavong, Nutwara Saengwijit, Khanyanut Ojongpien, Prapassawan Tanlawan","doi":"10.1155/2024/9106500","DOIUrl":"https://doi.org/10.1155/2024/9106500","url":null,"abstract":"<p><strong>Background: </strong>Sarcopenia is prevalent in older adults. It is essential for nurses to sustain updated information regarding the knowledge of sarcopenia, particularly in relation to approaches to diagnosing and addressing sarcopenia. However, there are limited studies examining the attitudes and awareness of nurses in relation to this condition.</p><p><strong>Objective: </strong>To assess the attitude and knowledge of nurses regarding sarcopenia and correlation between positive attitude and scores on knowledge.</p><p><strong>Materials and methods: </strong>An electronic survey was carried out among the nurses of the Faculty of Medicine, Khon Kaen University, Thailand, during November 2022 and January 2024. This survey encompassed questionnaires aimed at evaluating the nurses' perspectives and understanding of sarcopenia. The participants were invited to complete the survey, and they were returned to the researchers for analysis.</p><p><strong>Results: </strong>A total of 231 nurses were recruited (response rate 46.2%). Only 58.4% of them were familiar with \"sarcopenia,\" while only 16% had confidence in diagnosing it. For general knowledge, they achieved a total score of 19/30 (63.3%). They demonstrated proficiency in \"etiology\" (75%), while their performance was fair in \"management and prevention\" (62.5%) and low in \"terminology & importance\" (50%) and \"diagnosis\" (50%). The correlation between positive attitude and knowledge on sarcopenia was 0.22 (<i>p</i> < 0.05).</p><p><strong>Conclusion: </strong>Nurses exhibited a reduced awareness regarding \"sarcopenia.\" Their comprehension about terminology, diagnosis, prevention, and management of this condition was limited. There was a weak correlation between positive attitude and knowledge. The findings emphasize the essentiality of augmenting the educational programs to enhance the recognition of sarcopenia among nurses.</p>","PeriodicalId":14933,"journal":{"name":"Journal of Aging Research","volume":"2024 ","pages":"9106500"},"PeriodicalIF":1.6,"publicationDate":"2024-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11412747/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142287856","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Lack of Intensity Control during an Exercise Program Is Related to a Limited Effect on Variables Responsible for Blood Pressure Regulation in Hypertensive Older Adults. 运动项目中缺乏强度控制对高血压老年人血压调节变量的影响有限
IF 1.6
Journal of Aging Research Pub Date : 2024-06-27 eCollection Date: 2024-01-01 DOI: 10.1155/2024/3128257
Roberta Fernanda da Silva, Thaís Amanda Reia, André Mourão Jacomini, Anderson Bernadino da Silva, Henrique Dos Santos Disessa, Henrique Luiz Monteiro, Anderson Saranz Zago
{"title":"Lack of Intensity Control during an Exercise Program Is Related to a Limited Effect on Variables Responsible for Blood Pressure Regulation in Hypertensive Older Adults.","authors":"Roberta Fernanda da Silva, Thaís Amanda Reia, André Mourão Jacomini, Anderson Bernadino da Silva, Henrique Dos Santos Disessa, Henrique Luiz Monteiro, Anderson Saranz Zago","doi":"10.1155/2024/3128257","DOIUrl":"10.1155/2024/3128257","url":null,"abstract":"<p><p>To compare the effect of an intensity-controlled exercise program (ICEP) and a nonintensity-controlled exercise program (non-ICEP) on the variables responsible for blood pressure regulation in hypertensive older adults. 95 hypertensive older adults (65.40 ± 7.48 years/22 males and 73 females) performed hemodynamic, functional fitness, and biochemical evaluations before and after 12 weeks of the multicomponent exercises which included walking, muscle strength, hydrogymnastics, Pilates, dynamic balance, agility, flexibility, and others. A significant improvement was observed in general functional fitness index (GFFI: <i>p</i> ≤ 0.000, <i>d</i> = 0.35), nitrite (NO<sub>2</sub> <sup>-</sup>: <i>p</i> ≤ 0.000, <i>d</i> = 0.49), systolic blood pressure (SBP: <i>p</i> ≤ 0.000, <i>d</i> = 0.65), diastolic blood pressure (DBP: <i>p</i> ≤ 0.013, <i>d</i> = 0.40), thiobarbituric acid reactive substances (TBARS: <i>p</i> ≤ 0.007, <i>d</i> = 0.78), activity of the endothelial superoxide dismutase enzyme (ecSOD: <i>p</i> ≤ 0.032, <i>d</i> = 0.41), double product (DP: <i>p</i> ≤ 0.015, <i>d</i> = 0.43), and waist-hip ratio (WHR: <i>p</i> ≤ 0.000, <i>d</i> = 0.44) for ICEP. Only GFFI (<i>p</i> ≤ 0.047, <i>d</i> = 0.12), TBARS (<i>p</i> ≤ 0.000, <i>d</i> = 0.77), SOD (<i>p</i> ≤ 0.025, <i>d</i> = 0.25), DP (<i>p</i> ≤ 0.046, <i>d</i> = 0.26), and BMI (<i>p</i> ≤ 0.018, <i>d</i> = 0.02) presented better results in non-ICEP. When the effect of the groups (controlled by age, BMI, and sex) was evaluated, an increase was observed in the NO<sub>2</sub> <sup>-</sup>, TBARS, and SOD and a reduction in the SBP and WHR variables in the ICEP group compared to the non-ICEP group. Twelve weeks of engagement in a controlled-intensity exercise program was enough to improve the level of functional fitness and variables regarding blood pressure regulation in hypertensive older adults. Conversely, physical exercise performed without intensity control was related to the limited effect on such variables.</p>","PeriodicalId":14933,"journal":{"name":"Journal of Aging Research","volume":"2024 ","pages":"3128257"},"PeriodicalIF":1.6,"publicationDate":"2024-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11223912/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141534485","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Sleep Quality and Subjective Cognitive Decline among Older Adults: The Mediating Role of Anxiety/Depression and Worries. 老年人的睡眠质量与主观认知能力下降:焦虑/抑郁和担忧的中介作用
IF 4.7
Journal of Aging Research Pub Date : 2024-05-07 eCollection Date: 2024-01-01 DOI: 10.1155/2024/4946303
McKenna Sun, Qianqian Zhang, Yifei Han, Jianghong Liu
{"title":"Sleep Quality and Subjective Cognitive Decline among Older Adults: The Mediating Role of Anxiety/Depression and Worries.","authors":"McKenna Sun, Qianqian Zhang, Yifei Han, Jianghong Liu","doi":"10.1155/2024/4946303","DOIUrl":"10.1155/2024/4946303","url":null,"abstract":"<p><strong>Background: </strong>Subjective cognitive decline (SCD) in older individuals has been implicated as a possible precursor to Alzheimer's disease. Poor sleep quality and anxiety/depressive symptoms have been linked to the progression of SCD, but these associations and older adults' worries have yet to be fully established in the Chinese older adult population, which is one of the largest in the world. The aim of this study was to explore the relationship between sleep quality, anxiety/depression symptoms, and worries, and SCD prevalence among Chinese community-dwelling older individuals.</p><p><strong>Methods: </strong>A total of 707 adults aged between 60 and 99 from Shanghai, China, completed self-report questionnaires that covered their cognitive and mental well-being, as well as demographic information. Subjective cognitive decline (SCD) was evaluated using the memory/cognition syndromes of the old adult self-report (OASR). Sleep quality, anxiety/depression, and worries were measured from their respective sections of the OASR.</p><p><strong>Results: </strong>The general linear regression models showed that poorer sleep quality was associated with an increased prevalence of anxiety/depression symptoms, worries, and SCD among older adults. As suggested by the mediation analysis, anxiety/depression and worries were significant mediators in the relationship between sleep quality and SCD prevalence, and these two factors also have a serial mediation effect between sleep quality and SCD prevalence.</p><p><strong>Conclusions: </strong>Poorer sleep quality is associated with a higher rate of SCD among older adults, and a higher prevalence of anxiety/depression and worries mediate this relationship, suggesting possible mechanism pathways that lead to SCD. These factors may provide the basis for early, targeted interventions for older adults' mental health preservation and improved quality of life.</p>","PeriodicalId":14933,"journal":{"name":"Journal of Aging Research","volume":"2024 ","pages":"4946303"},"PeriodicalIF":4.7,"publicationDate":"2024-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11093690/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140921932","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Effects of Mind-Body Qigong Exercise on Overall Health, Fatigue/Sleep, and Cognition in Older Chinese Immigrants in the US: An Intervention Study with Control. 心身气功锻炼对美国老年华人移民整体健康、疲劳/睡眠和认知的影响:带对照的干预研究
IF 1.6
Journal of Aging Research Pub Date : 2024-01-31 eCollection Date: 2024-01-01 DOI: 10.1155/2024/2481518
Jianghong Liu, Yi Yang, Clara Li, Adriana Perez, Adrian Raine, Haoer Shi, Liye Zou
{"title":"Effects of Mind-Body Qigong Exercise on Overall Health, Fatigue/Sleep, and Cognition in Older Chinese Immigrants in the US: An Intervention Study with Control.","authors":"Jianghong Liu, Yi Yang, Clara Li, Adriana Perez, Adrian Raine, Haoer Shi, Liye Zou","doi":"10.1155/2024/2481518","DOIUrl":"10.1155/2024/2481518","url":null,"abstract":"<p><strong>Background: </strong>Culturally relevant exercises may help improve health and address disparities faced by older immigrants due to language and cultural barriers. Few studies have focused on such exercise interventions among older Chinese immigrants at US daycare centers.</p><p><strong>Methods: </strong>We conducted a 10-week nonrandomized controlled trial in older Chinese immigrants in Philadelphia, US. The intervention group practiced Chinese Qigong (Baduanjin) 5 days a week guided by trained research assistants and video instructions. The control group maintained their usual daily activities. We collected self-report assessments on overall health, sleep, and fatigue and implemented two computerized cognitive tests measuring psychomotor vigilance task (PVT) and memory twice, preintervention and postintervention. Repeated measures general linear model (GLM) and paired samples <i>t</i>-tests were used for data analyses.</p><p><strong>Results: </strong>Eighty-eight older adults (Qigong, <i>n</i> = 53; control, <i>n</i> = 35) with an average age of 78.13 (SD = 5.05) were included. Groups showed no significant differences at baseline evaluation. After the 10-week exercise, the intervention group showed significant improvements in overall health (<i>p</i>=0.032), fatigue (<i>p</i> < 0.001), and cognitive functions including memory (<i>p</i>=0.01), response speed (<i>p</i>=0.002), and response time (<i>p</i>=0.012) on the PVT, as well as marginally significant benefits in sleep (<i>p</i>=0.058). Between-group comparisons identified significant group-by-time interactions in health (<i>p</i>=0.024), sleep (<i>p</i>=0.004), fatigue (<i>p</i>=0.004), and memory (<i>p</i>=0.004).</p><p><strong>Conclusion: </strong>We revealed significant positive effects of Qigong in older Chinese immigrants across multiple health domains. Findings highlight the potential of a culturally relevant exercise in addressing health disparities.</p>","PeriodicalId":14933,"journal":{"name":"Journal of Aging Research","volume":"2024 ","pages":"2481518"},"PeriodicalIF":1.6,"publicationDate":"2024-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10849816/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139706762","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Do-Not-ResuscitateDecision-Making during the COVID-19 Pandemic in a Teaching Hospital: Lessons Learned for the Future 一家教学医院在 COVID-19 大流行期间的 "不急救 "决策:未来的经验教训
IF 4.7
Journal of Aging Research Pub Date : 2023-12-20 DOI: 10.1155/2023/2771149
Mick van de Wiel, Sabrina van Ierssel, Walter Verbrugghe, Veerle Mertens, A. Janssens
{"title":"Do-Not-ResuscitateDecision-Making during the COVID-19 Pandemic in a Teaching Hospital: Lessons Learned for the Future","authors":"Mick van de Wiel, Sabrina van Ierssel, Walter Verbrugghe, Veerle Mertens, A. Janssens","doi":"10.1155/2023/2771149","DOIUrl":"https://doi.org/10.1155/2023/2771149","url":null,"abstract":"Rationale. Contribute to the understanding of DNR decision-making and conducting end-of-life conversations, about which there is a paucity of data available in the current literature. Aims and Objectives. Assess how the decision-making process to determine a DNR code is implemented in the day-to-day clinical practice in a tertiary teaching hospital. Familiarity with the use of different scores as a possible objective support for DNR decisions and the influence of various elements on a DNR decision was explored. Method. A cross-sectional survey study was conducted between February 2021 and April 2021 for all doctors and doctors in training, working in the Antwerp University Hospital during the COVID-19 pandemic. Results. 127 doctors participated in this study. The familiarity with the different scores used in the triage during the COVID-10 pandemic was 51% for the Clinical Frailty Scale (CFS) and 20% for the Charlson Comorbidity Index (CCI). Participants indicated that their DNR decision is based on various aspects such as clinical assessment, comorbidities, patient’s wishes, age, prognosis, and functional state. Conclusion. The familiarity with the different scores used during triage assessments is low. The total clinical picture of the patient is needed to make a considered decision, and this total picture of the patient seems to be well encompassed by frailty measurement (CFS). Although many participants indicated that the different scores do not offer much added value compared to their clinical assessment, it can help guide DNR decisions, especially for doctors in training.","PeriodicalId":14933,"journal":{"name":"Journal of Aging Research","volume":"10 9","pages":""},"PeriodicalIF":4.7,"publicationDate":"2023-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138955990","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Health Service Utilization and Its Determinants among Senior Citizens in the Semiurban Area of Western Nepal: A Cross-Sectional Study 尼泊尔西部半城市地区老年人对医疗服务的利用及其决定因素:横断面研究
IF 4.7
Journal of Aging Research Pub Date : 2023-12-19 DOI: 10.1155/2023/3655259
Yamuna Chhetri, Dhurba Khatri, N. Gahatraj
{"title":"Health Service Utilization and Its Determinants among Senior Citizens in the Semiurban Area of Western Nepal: A Cross-Sectional Study","authors":"Yamuna Chhetri, Dhurba Khatri, N. Gahatraj","doi":"10.1155/2023/3655259","DOIUrl":"https://doi.org/10.1155/2023/3655259","url":null,"abstract":"Background. Senior citizens are usually infected by multiple chronic conditions and other health problems. Health needs and demand for healthcare services increase with age. However, healthcare services and facilities and their utilization are limited, particularly in developing countries. Aims. To identify the utilization of health services among senior citizens and their contributing factors. Methods. A cross-sectional analytic study was conducted among 293 senior citizens of the Kushma municipality, Nepal, from June to December 2019. A structured questionnaire was used as a data collection tool using a multistage sampling technique. Face-to-face interviews were conducted to collect data on the interview schedule. Reliability and validity were maintained by applying different strategies and carefully developing tools, pretesting, double entry, and validation. Data entry, management, and analysis were performed using Epi Data and SPSS software. Research ethics were maintained. Descriptive and inferential statistical tests were performed to infer the findings. Results. Study participants had a mean age (±SD) of 70.08 (±7.6) years and had various preexisting chronic diseases such as hypertension (46%), gastritis (41.9%), arthritis (34.3%), and asthma (28.7%). Only eight out of ten senior citizens had used health services in the past year. Factors such as age, ethnicity, residency, household income, family support, the presence of chronic diseases, and being under medication were found to have statistically significant associations with the utilization of health services among senior citizens with a \u0000 \u0000 p\u0000 \u0000 value less than 0.05 and 95% confidence interval. Conclusions. A remarkable proportion of older people reported using health services in the last year. However, a substantial proportion did not utilize health services that require further interventions to enable them. Efforts are required to promote the health and well-being of Nepal’s growing elderly population, including potential enhancements to rural healthcare infrastructure by policymakers.","PeriodicalId":14933,"journal":{"name":"Journal of Aging Research","volume":" 917","pages":""},"PeriodicalIF":4.7,"publicationDate":"2023-12-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138960284","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Melamine Exacerbates Neurotoxicity in D-Galactose-Induced Neuronal SH-SY5Y Cells. 三聚氰胺加剧了d -半乳糖诱导的神经元SH-SY5Y细胞的神经毒性。
IF 4.7
Journal of Aging Research Pub Date : 2023-11-23 eCollection Date: 2023-01-01 DOI: 10.1155/2023/6635370
Juhi Goyal, Preet Jain, Vivek Jain, Dibyajyoti Banerjee, Rajasri Bhattacharyya, Sharmistha Dey, Rambabu Sharma, Nitish Rai
{"title":"Melamine Exacerbates Neurotoxicity in D-Galactose-Induced Neuronal SH-SY5Y Cells.","authors":"Juhi Goyal, Preet Jain, Vivek Jain, Dibyajyoti Banerjee, Rajasri Bhattacharyya, Sharmistha Dey, Rambabu Sharma, Nitish Rai","doi":"10.1155/2023/6635370","DOIUrl":"10.1155/2023/6635370","url":null,"abstract":"<p><p>Numerous studies have depicted the role of diet and environmental toxins in aging. Melamine (Mel) is a globally known notorious food adulterant, and its toxicity has been shown in several organs including the brain. However, till now, there are no reports regarding Mel neurotoxicity in aging neurons. So, this study examined the <i>in vitro</i> neurotoxicity caused by Mel in the D-galactose (DG)-induced aging model of neuronal SH-SY5Y cells. In the present study, the neuronal SH-SY5Y cells were treated with DG and Mel separately and in combination to assess the neurotoxicity potential using MTT assay and neurite length measurement. Further, the superoxide dismutase (SOD), catalase (CAT), and total antioxidant activities were evaluated followed by the determination of the intracellular reactive oxygen species (ROS), mitochondrial membrane potential (MMP), and caspase3 (Casp3) activity. The cotreatment of Mel and DG in neuronal SH-SY5Y cells showed maximum cell death than the cells treated with DG or Mel individually and untreated control cells. The neurite length shrinkage and ROS production were maximum in the DG and Mel cotreated cells showing exacerbated toxicity of Mel. The activity of SOD, CAT, and total antioxidants was also found to be lowered in the cotreatment group (Mel + DG) than in Mel- or DG-treated and untreated cells. Further, the combined toxicity of Mel and DG also elevated the Casp3 activity more than any other group. This is the first study showing the increased neurotoxic potential of Mel in an aging model of neuronal SH-SY5Y cells which implicates that Mel consumption by the elderly may lead to increased incidences of neurodegeneration like Alzheimer's disease and Parkinson's disease.</p>","PeriodicalId":14933,"journal":{"name":"Journal of Aging Research","volume":"2023 ","pages":"6635370"},"PeriodicalIF":4.7,"publicationDate":"2023-11-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10689074/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138477739","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Examining Outcomes and Challenges of Telepsychiatry in Australian Elderly: A Scoping Review. 澳大利亚老年人远程精神病学的研究结果和挑战:范围界定综述。
IF 4.7
Journal of Aging Research Pub Date : 2023-10-17 eCollection Date: 2023-01-01 DOI: 10.1155/2023/8864591
Sodabeh Abazari, Khadijeh Moulaei, Manoj George
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