Journal of Aging Research最新文献

{"title":"A Novel Anthropometry-Based Model to Estimate Appendicular Muscle Mass in Brazilian Older Women.","authors":"Carlos Aiello Ribeiro, Lorena Rosa, Jorge Mota, Nádia Lima da Silva, Paulo Farinatti","doi":"10.1155/jare/1053086","DOIUrl":"10.1155/jare/1053086","url":null,"abstract":"<p><p><b>Background:</b> The assessment of appendicular skeletal muscle mass (ASM) is central to the diagnosis of sarcopenia (SA). We developed an anthropometric model for estimating ASM and tested its validity to identify SA and associated risk of disability (RSA) in older women. <b>Methods:</b> The equation was developed with 89 women (60-88 years, 72 ± 6 years), with a cross-validation sample of 12 women (60-84 years, 67 ± 5 years). Validity was determined through concordance between actual versus estimated ASMs, correlations between actual/estimated ASM versus peak torque (PT) and total work (TW) during isokinetic knee extension/flexion and handgrip strength, and agreement of patients classified with SA and RSA. <b>Results:</b> The predictive equation was ASM (kg) = 0.177 (body mass, kg)-0.075 (arm circumference, cm) + 0.020 (thigh circumference, cm) + 5.376 (<i>R</i> = 0.905; <i>R</i> ² = 0.819; <i>R</i> ²ad = 0.809; <i>F</i> = 86.96; <i>p</i> < 0.0001; SEE = 1.35 kg). Agreement between actual and estimated ASMs was confirmed by validation (ICC = 0.81; <i>p</i> < 0.0001) and cross-validation samples (ICC = 0.72, <i>p</i> < 0.035). Regression characteristics in PRESS statistics (<i>R</i> ² PRESS = 0.79; SEE-PRESS = 1.61) were compatible with the original model. Percent agreements for the classification of SA and RSA from indices calculated using actual/estimated ASM were 98% (gamma = 0.98, <i>p</i> = 0.015) and 68% (gamma = 0.89, <i>p</i> < 0.0001) in validation and 67% (gamma = 1.0, <i>p</i> = 0.032) and 70% (gamma = 0.84, <i>p</i> < 0.001) in cross-validation samples. Correlations between actual/estimated ASM versus PT (range 0.57-0.76, <i>p</i> < 0.05), TW (range 0.51-0.75, <i>p</i> < 0.05), and handgrip (range 0.67-0.74, <i>p</i> < 0.001) were theoretically consistent, being moderate and similar in both samples. <b>Conclusion:</b> This new anthropometric model has satisfactory prediction qualities and could be applied as a simple and practical method for estimating ASM in Brazilian older women.</p>","PeriodicalId":14933,"journal":{"name":"Journal of Aging Research","volume":"2025 ","pages":"1053086"},"PeriodicalIF":1.6,"publicationDate":"2025-03-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11972132/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143795304","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Identification of Therapeutic Potential of Hydroxychavicol Against Alzheimer's Disease: An Integrated Network Pharmacology, Molecular Docking, and Dynamic Simulation Study.","authors":"Priyank Upadhayay, Saurabh K Sinha, Neeraj Kumar, Shashi Kant Singh, Preet Jain, Sunita Panchawat, Nitish Rai","doi":"10.1155/jare/7062203","DOIUrl":"10.1155/jare/7062203","url":null,"abstract":"<p><p>Alzheimer's disease (AD) is a commonly occurring neurodegenerative disease in elderly and it is a leading cause of dementia worldwide. Hydroxychavicol (HC), a major phenolic component of <i>Piper betle,</i> has prominent anti-inflammatory and antioxidant properties, and studies have found its role in cognition improvement. Here is a systematic approach to deciphering the potential protein targets of HC in AD through network pharmacology and validation from molecular docking and dynamics simulation study. First, the druglikeliness of HC was predicted using the SwissADME analysis, which showed significant druglikeliness. A total of 88 possible target genes between HC and AD were obtained from the Swiss Target Prediction, HIT Version 2, DisGeNET, and GeneCards database. The pathway analysis was carried out using the STRING database which showed several genes including COMT, HSP90AA1, and GAPDH as the top hub genes on the basis of degree. GO and KEGG analyses demonstrated that the core targets were mainly involved in cAMP, PI3K/AkT, HIF1, Rap1, and Calcium signaling pathways. The molecular docking of HC with top hub genes resulted in the highest binding of HC with COMT (-8.9 kcal/mol), GAPDH (-6.7 kcal/mol), and HSP90AA1 (-6.5 kcal/mol) that showed stable binding in the molecular dynamics simulation study. COMT regulates the dopamine levels in the prefrontal cortex and impairment of the COMT is associated with the rapid progression of AD. HSP90, a ubiquitous molecular chaperone, is involved in regulating tau metabolism and Aβ processing and found to be downregulated in AD. GAPDH has been reported as the disease-susceptible gene in AD and its interaction with amyloid precursor protein and NFTs has also been reported. These findings suggest that HC is a promising therapeutic candidate, targeting multiple AD-related pathways, warranting further investigation into its molecular mechanisms and potential for clinical application.</p>","PeriodicalId":14933,"journal":{"name":"Journal of Aging Research","volume":"2025 ","pages":"7062203"},"PeriodicalIF":1.6,"publicationDate":"2025-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11961278/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143764078","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Examining the Heterogeneity of Exercise Response Among Sedentary Older Adults: A Descriptive Analysis.","authors":"Grace L Kulik, Melissa P Wilson, Catherine M Jankowski, Lindsay T Fourman, Kristine M Erlandson","doi":"10.1155/jare/6952002","DOIUrl":"10.1155/jare/6952002","url":null,"abstract":"<p><p><b>Background:</b> Significant heterogeneity in individual responses to exercise interventions provides an opportunity to identify individuals for whom modifications or adjunct therapies may be necessary. Here, we explore heterogeneity of exercise response among people with HIV (PWH) versus without HIV (control). <b>Methods:</b> The Exercise for Healthy Aging Study enrolled sedentary older PWH and controls (50-75 years old) for a 24-week aerobic and resistance exercise program. Responder groups were categorized based on minimally clinically important differences for cardiovascular (CV), strength, and lean mass (LM) outcomes. Descriptive statistics were used to examine baseline characteristics of the different groups. <b>Results:</b> 32 PWH and 37 controls (age 58 ± 6.5 years) were enrolled. CV nonresponders were more likely to have HIV infection, a greater comorbidity burden, and lower baseline CV fitness. Strength nonresponders had a lower comorbidity burden and greater strength at baseline. Comorbidities were similar across LM responder groups. CV and LM nonresponders had an increase in inflammatory markers from baseline to week 24 compared to decreased inflammatory markers among CV and LM responders. <b>Conclusion:</b> Lower CV fitness and HIV infection was more prevalent among those with poorer exercise response, suggesting that higher intensity or a prolonged duration of aerobic exercise may be required to overcome blunted CV adaptations particularly among PWH. Associations of CV and LM response with inflammatory markers should be further explored to determine if and when blocking inflammation might enhance exercise responses. <b>Trial Registration:</b> ClinicalTrials.gov identifier: NCT02404792.</p>","PeriodicalId":14933,"journal":{"name":"Journal of Aging Research","volume":"2025 ","pages":"6952002"},"PeriodicalIF":1.6,"publicationDate":"2025-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11936528/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143708169","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Organizational Work, Well-Being, and Quality of Life at an Elderly Age: The Case of Cyprus.","authors":"George Papageorgiou, Panagiota Athanasiadou, Elena Tsappi, Sofia A Xergia, Athanasios Maimaris, Andreas Efstathiades","doi":"10.1155/jare/7194723","DOIUrl":"10.1155/jare/7194723","url":null,"abstract":"<p><p>This study investigates the impact of postretirement organizational work on the well-being and overall quality of life of the elderly population in Cyprus. Specifically, it evaluates the multifaceted effects of continued employment after retirement, based on data collected through a survey administered to a representative sample of elderly Cypriots. The research findings, informed by prominent instruments in the field, demonstrate significant enhancements in autonomy, self-actualization, and both physical and psychological well-being for the elderly as a result of continuing to work beyond retirement age. Through inferential statistical analysis, the study identifies several key factors contributing to significant improvements in people's lives. Particularly, the findings reveal a positive correlation between sustained employment and several aspects of quality of life, challenging conventional views on retirement. These insights hold particular relevance for the Cypriot context and suggest broader implications for policymaking that encourage postretirement employment as a means to enhance well-being in countries with aging populations. Overall, this paper contributes to the discourse on organizational work, aging, and quality of life by offering evidence-based policy recommendations for enhancing human self-actualization and well-being through sustainable professional engagement.</p>","PeriodicalId":14933,"journal":{"name":"Journal of Aging Research","volume":"2025 ","pages":"7194723"},"PeriodicalIF":1.6,"publicationDate":"2025-02-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11865462/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143523403","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Navigating the Digital Divide: Exploring the Drivers, Drawbacks, and Prospects of Social Interaction Technologies' Adoption and Usage Among Older Adults During COVID-19.","authors":"Daniel Katey, Sally Chivers","doi":"10.1155/jare/7625097","DOIUrl":"10.1155/jare/7625097","url":null,"abstract":"<p><p>The COVID-19 pandemic underscored the critical role of social interaction technologies (SITs) in mitigating loneliness and social isolation, particularly among older adults. However, challenges such as the digital divide, physical and cognitive declines, and digital literacy gaps persist. This article seeks to explore the drivers, drawbacks, and prospects of SITs' adoption during the pandemic. The paper employs a narrative review approach, using targeted phrases and keywords, including \"COVID-19 pandemic and digital engagement,\" \"digital technologies usage among older adults/people during COVID-19,\" and \"drivers of digital technologies adoption among older adults/people during COVID-19.\" Articles were retrieved through Google Scholar searches conducted between October 2023 and December 2024. In line with key findings, we propose evidence-based recommendations, including user-centered digital communication technology design, the need to balance digital engagement with healthy physical activity, and personalized digital literacy programs, to enhance SITs' accessibility and usability for older adults.</p>","PeriodicalId":14933,"journal":{"name":"Journal of Aging Research","volume":"2025 ","pages":"7625097"},"PeriodicalIF":1.6,"publicationDate":"2025-01-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11742077/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143005895","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Psychometric Properties of the Persian Version of Sickness Impact Profile-30 (SIP-30) in Community-Dwelling Older Adults.","authors":"Sajad Siavash, Amin Ghaffari, Ghorban Taghizadeh, Laleh Lajevardi, Akram Azad","doi":"10.1155/jare/9959086","DOIUrl":"10.1155/jare/9959086","url":null,"abstract":"<p><p><b>Purpose:</b> Accurate measurement tools are essential for evaluating the health-related quality of life in older adults. We aimed to translate and evaluate the psychometric properties of the Sickness Impact Profile-30 (SIP-30) in community-dwelling older adults. <b>Materials and Methods:</b> One hundred and fifty older adults participated in this study. To evaluate construct validity, its correlation with General Health Questionnaire-28, Geriatric Depression Scale-15, Hospital Anxiety and Depression Scale, Modified Health Assessment Questionnaire, Numeric Pain Rating Scale, and Fullerton Advanced Balance Scale was assessed. Reliability features were also investigated. <b>Results:</b> The results of construct validity analysis demonstrated a moderate to high (<i>r</i> = 0.61-0.84) correlation between the total score of SIP-30 and GHQ-28, GDS-15, HADS, MHAQ, and NPRS. There was a moderate inverse (<i>r</i> = -0.67) correlation between the total score of the SIP-30 and the FAB Scale. Test-retest reliability (ICC > 0.83) and internal consistency (<i>α</i> = 0.94) of the Persian SIP-30 were high. <b>Conclusions:</b> The results indicated that the Persian SIP-30 is a reliable and valid measure to assess health-related quality of life in community-dwelling older adults.</p>","PeriodicalId":14933,"journal":{"name":"Journal of Aging Research","volume":"2025 ","pages":"9959086"},"PeriodicalIF":1.6,"publicationDate":"2025-01-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11730014/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143005897","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Middle-Aged and Young People's Perspectives on Healthy Aging Through Exercise: Environmental, Psychosocial, and Individual Factors With the Photovoice Method.","authors":"Aysu Önal, Gökhan Deliceoğlu","doi":"10.1155/jare/4578688","DOIUrl":"10.1155/jare/4578688","url":null,"abstract":"<p><p>The aim of this study is to examine the individual's perspective on healthy aging through exercise. Individuals aged 18-60 years who have been physically active for at least one year were included in this study. The study focused on the exercise behaviors of young and middle-aged individuals through photographs. The photovoice method was used to discover how healthy aging affects exercise behaviors in physically active individuals. Content analysis was used to analyze photographs and the photovoice of the participants. Environmental, psychosocial, and individual themes emerged with the interpretation of the data. According to the results of this study, environmental, psychosocial, and individual factors have been found to be effective for healthy aging. The contribution of exercise to personal development was beneficial in strengthening the network of interpersonal relationships and improving physical and mental health in young and middle-aged adults. Exercise programs should not be monotonous, and individuals should not depend on a single location for exercise.</p>","PeriodicalId":14933,"journal":{"name":"Journal of Aging Research","volume":"2024 ","pages":"4578688"},"PeriodicalIF":1.6,"publicationDate":"2024-12-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11685322/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142914955","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Psychiatric Goals of Care at the End of Life: A Qualitative Analysis of Medical Records at a Geriatric Psychiatric Outpatient Clinic.","authors":"Helena Kullenberg, Gert Helgesson, Niklas Juth, Anna Lindblad","doi":"10.1155/jare/2104985","DOIUrl":"10.1155/jare/2104985","url":null,"abstract":"<p><p><b>Objectives:</b> Person-centered care emphasizes patient choice and autonomy and is considered an important means for improving the quality of care and quality of life for older adults with multiple chronic conditions and functional limitations. In implementing person-centered care, goals of care based on the patient's preferences are considered fundamental. Psychiatry is generally practiced in a curative paradigm, and little is known about the goals of care in geriatric psychiatric settings. In this study, goals of care as documented in care plans and medical records in geriatric psychiatric outpatient care have been explored, with a special focus on the end of life. <b>Methods:</b> This study was based on a descriptive qualitative content analysis of medical records of patients enrolled at an outpatient clinic for geriatric psychiatry at the time of death. It was complemented by a basic quantitative analysis of patient characteristics. <b>Results:</b> A total of 66 medical records were included, with a male/female ratio of 41/59% and a mean age of 83 years (66-104 years). Among psychiatric diagnoses, depression predominated. The dataset was generally limited, and clearly defined goals of care were sparsely presented. Therefore, the included medical records were analyzed twice: first regarding goals of care and second regarding patient wishes and requests. In both cases, the highest level of abstraction in terms of themes was achieved. Analysis of goals of care resulted in the themes patient well-being and care arrangements. Analysis of patient wishes resulted in the themes active patienthood and living and being. <b>Conclusion:</b> Goals of care were often disease-oriented, focusing on recovery or symptom management, whereas analysis of patients' wishes revealed personal goals other than remission, including outspoken existential needs. The results call for further research on the interplay between person-centered care and the goal-planning process and point to the potential of a palliative approach in geriatric psychiatric care involving patients with complex comorbidities and multilevel needs.</p>","PeriodicalId":14933,"journal":{"name":"Journal of Aging Research","volume":"2024 ","pages":"2104985"},"PeriodicalIF":1.6,"publicationDate":"2024-11-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11623991/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142800895","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effectiveness of Online Traditional Exercise Program on the Stress Level of Elderly.","authors":"Suwat Jitdamrong, Kunlasatree Jumpathong, Choladda Nanglad, Yadaporn Ketkaeo, Dolrada Malicum, Ormjai Taejarernwiriyakul","doi":"10.1155/jare/9332171","DOIUrl":"10.1155/jare/9332171","url":null,"abstract":"<p><p><b>Objective:</b> This quasi-experimental research was to assess the effect of online traditional dance exercise program on stress among elderly in Nakhon Nayok province, Thailand. <b>Methods:</b> The elderly living in Nakhon Nayok province were recruited for the study. Multistage random sampling was employed to select participants. There is a total of 27 elderly people classified as experimental Group 15 people (received a 4-week online traditional dance exercise program) and control Group 12 people. Exercise data collected by the SPST20, pre- and postintervention testing was used to measure stress. An independent <i>t</i>-test analyses were performed to assess the effectiveness of program interventions. <b>Results:</b> After the program, there were statistically significant differences in mean scores of stress between the experimental and the control group. The level of stress of the elderly in the experimental group had decreased within and between groups after 4-week (<i>p</i> value < 0.05). <b>Conclusion:</b> Effectiveness of online traditional dance exercise program on the stress level of the elderly. It can reduce stress levels in the elderly. It could be applied with elderly in the community healthcare setting.</p>","PeriodicalId":14933,"journal":{"name":"Journal of Aging Research","volume":"2024 ","pages":"9332171"},"PeriodicalIF":1.6,"publicationDate":"2024-11-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11620804/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142785863","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Predictors for the Level of Quality of Life Among Older Adults: Approaches to the Effect of Sociodemographic and Chronic Diseases.","authors":"Khulud Ahmad Rezq, Maadiah M Algamdi, Futun Alatawi, Danah Altamimi, Nouf Albalawi, Atheer Albalawi, Taghreed Abed, Dana Alatawi, Reem Alhthli","doi":"10.1155/jare/5436660","DOIUrl":"https://doi.org/10.1155/jare/5436660","url":null,"abstract":"<p><p><b>Objectives:</b> This cross-sectional study aimed to assess the quality of life (QOL) and chronic disease prevalence among 265 individuals over the age of 60. <b>Methods:</b> Utilizing the quality-of-life index (QLI), data were collected through an online questionnaire from eligible participants, not mentally disabled. <b>Results:</b> Significant variations in chronic conditions were found based on marital status, education, employment, and daily activities. QOL declined with age, divorce, unemployment, and dependency on caregivers but improved with a university degree. Living with family positively impacted overall QOL, while older age, unemployment, dependency, hypertension, and kidney disease were associated with lower QOL scores across various domains. <b>Conclusion:</b> Sociodemographic factors and chronic conditions had pivotal role in shaping the QOL for individuals over the age of 60, emphasizing the importance of targeted interventions for improved well-being in this population.</p>","PeriodicalId":14933,"journal":{"name":"Journal of Aging Research","volume":"2024 ","pages":"5436660"},"PeriodicalIF":1.6,"publicationDate":"2024-11-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11608296/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142769153","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}