Journal of Aging Research最新文献

{"title":"The Cost-Benefit of Aging: Financial Capability and Well-Being across Age Groups in Brazil.","authors":"Eduarda A S R G da Silva,&nbsp;César A T Silva","doi":"10.1155/2023/2020189","DOIUrl":"https://doi.org/10.1155/2023/2020189","url":null,"abstract":"<p><p>A large proportion of older persons in developing countries do not have access to pension, which also constrains their ability to afford healthcare services and entails extensive challenges to the well-being of older people. This study aimed to analyze the financial preparedness of different age groups for retirement in Brazil. Data were derived from a survey to empirically validate the proposed relationships between <i>preparedness for retirement</i> and <i>resilience for the future</i> (financial well-being (FWB) outcomes) on the one hand and among <i>demographic and socioeconomic</i> aspects, <i>behaviors and attitudes</i>, <i>knowledge and experience</i>, and \"key\" <i>psychological factors</i> on the other hand. The sample consisted of 412 individuals aged between 22 and 79 years. FWB was measured using the financial capability and well-being model and regressed on a number of sociodemographic and psychological variables using linear regression analyses. The results demonstrated that <i>preparedness for retirement</i> was strongly related to older age. Additionally, age was correlated with <i>resilience for the future</i> close to zero, which indicates no relationship. <i>Knowledge</i> and the <i>psychological factors</i> of self-control and confidence were positively and strongly related to better <i>financial behavior</i> for all age groups. In addition, g<i>rit</i> and <i>resilience for the future</i> were positively related to better <i>financial behavior</i> in the older age group. Furthermore, the variables of retirement contribution were seemingly not viewed as important to the older group compared with their young and mature counterparts. Multidimensional interventions, especially targeting <i>behaviors</i> and <i>psychological</i> patterns, could, therefore, be recommended in advance to young and mature groups to prepare them to secure their old age and achieve FWB.</p>","PeriodicalId":14933,"journal":{"name":"Journal of Aging Research","volume":"2023 ","pages":"2020189"},"PeriodicalIF":4.7,"publicationDate":"2023-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10581847/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49677683","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Association between Delirium and In-Hospital Falls: A Cross-Sectional Analysis of a Delirium Screening Program.","authors":"Benjamin Kalivas,&nbsp;Jingwen Zhang,&nbsp;Kristine Harper,&nbsp;Meghan K Thomas,&nbsp;Jennifer Dulin,&nbsp;Justin Marsden,&nbsp;Patrick Robbins,&nbsp;Kelly J Hunt,&nbsp;Patrick D Mauldin,&nbsp;William P Moran,&nbsp;James Rudolph,&nbsp;Marc Heincelman","doi":"10.1155/2023/1562773","DOIUrl":"https://doi.org/10.1155/2023/1562773","url":null,"abstract":"<p><strong>Methods: </strong>A cross-sectional study using delirium screening and falls reports was used to measure the association between delirium and falls. All inpatient data from August, 2018, to January, 2020, at a large academic medical center were analyzed. A multivariable logistic regression of 29,655 hospital admissions was used to understand the association between in-hospital delirium and falls.</p><p><strong>Results: </strong>Analysis revealed a delirium rate of 12.5% (<i>n</i> = 3,707) of all admissions and 286 (0.9%) admissions with falls; of the falls studied, 37.6% of these patients screened positive for delirium during their admission. Relative to those who screened negative for delirium, admissions that screened positive for delirium had a 2.81 increased odds of falling.</p><p><strong>Conclusions: </strong>Delirium and falls are related. This strong association should motivate health systems to look closely at both problems. Falls and delirium can both have immense impacts on the patient and the health system. The powerful association between them provides a window to reduce these additional patient harms. More specifically, a modern delirium screening tool should be used as part of routine risk assessment focused on reducing in-hospital falls.</p>","PeriodicalId":14933,"journal":{"name":"Journal of Aging Research","volume":"2023 ","pages":"1562773"},"PeriodicalIF":4.7,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9902156/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10689125","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"MAOA uVNTR Polymorphism Influence on Older Adults Diagnosed with Diabetes Mellitus/Systemic Arterial Hypertension.","authors":"Gabriel Moura Alves Seixas,&nbsp;Renata de Souza Freitas,&nbsp;Caroline Ferreira Fratelli,&nbsp;Calliandra Maria de Souza Silva,&nbsp;Luciano Ramos de Lima,&nbsp;Marina Morato Stival,&nbsp;Silvana Schwerz Funghetto,&nbsp;Izabel Cristina Rodrigues da Silva","doi":"10.1155/2023/8538027","DOIUrl":"https://doi.org/10.1155/2023/8538027","url":null,"abstract":"<p><strong>Background: </strong>Monoamine oxidase (MAO) is involved in several biological processes associated with well-being and mental health, and alterations in its function might directly impact various mental disorders. Some mental disorders concomitantly occur in individuals with clinical characteristics, such as substance abuse and diabetes.</p><p><strong>Objective: </strong>To analyze the functional MAOA uVNTR polymorphism genotype frequency in an older adult population with diabetes mellitus/arterial hypertension and associate this frequency with clinical characteristics impacting daily life. <i>Methodology</i>. Older adults diagnosed with diabetes mellitus, systemic arterial hypertension, or both (DM/SAH) were selected and had their MAOA gene genotyped for uVNTR polymorphism. The revised Beck Depression Inventory (BDI) and a questionnaire were also applied to determine their mental health and clinical characteristics.</p><p><strong>Results: </strong>The allelic variants detected among the participants were the 2R, 3R, 4R, and 3R/4R heterozygous genotypes. Genotypes solely containing the 3R allele had patients who marked yes for smoking and alcoholism, and only those with the 3R genotypes (female 3R/3R homozygote or male 3R^<i>∗</i> hemizygote) were significant. Although not statistically significant, only 3R and 3R/4R genotypes presented cases of severe depression per the revised BDI interpretations.</p><p><strong>Conclusion: </strong>The MAOA uVNTR polymorphism's low-activity 3R allele presence in an older adult population diagnosed with DM/SAH may represent a risk for developing substance use (alcohol and smoking) dependence.</p>","PeriodicalId":14933,"journal":{"name":"Journal of Aging Research","volume":"2023 ","pages":"8538027"},"PeriodicalIF":4.7,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10393510/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9930350","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Anthropometric and Body Circumference Determinants for Hand Grip Strength: A Population-Based Mon-Timeline Study.","authors":"Agiimaa Byambaa,&nbsp;Indra Altankhuyag,&nbsp;Otgonbayar Damdinbazar,&nbsp;Tsolmon Jadamba,&nbsp;Oyuntugs Byambasukh","doi":"10.1155/2023/6272743","DOIUrl":"https://doi.org/10.1155/2023/6272743","url":null,"abstract":"<p><strong>Background: </strong>Hand grip strength (HGS) is a tool for diagnosing sarcopenia. In this study, we examined some anthropometric and body circumference measurements as determinants for HGS.</p><p><strong>Methods: </strong>This cross-sectional study was conducted with participants (Mongolians, <i>n</i> = 1080, aged 18-70, mean age of 41.2 ± 13.9 years, 33.7% of men) from the \"Mon-Timeline\" cohort study. To measure HGS, a digital grip strength dynamometer was used.</p><p><strong>Results: </strong>Mean HGS in men was 40.1 ± 10.4 kg and in women was 24.5 ± 5.6 kg. Correlation analysis showed that the strongest correlation with HGS was height (<i>r</i> = 0.712, <i>p</i> < 0.001). Moreover, HGS was inversely correlated with age (<i>r</i> = -0.239, <i>p</i> < 0.001) and thigh circumference (<i>r</i> = -0.070, <i>p</i> < 0.01), while it was positively correlated with body weight (<i>r</i> = 0.309, <i>p</i> < 0.001), neck circumference (<i>r</i> = 0.427, <i>p</i> < 0.001), upper arm circumference (<i>r</i> = 0.108, <i>p</i> < 0.0001), lower arm circumference (<i>r</i> = 0.413, <i>p</i> < 0.0001), and calf circumference (<i>r</i> = 0.117, <i>p</i> < 0.0001). In the multivariate linear regression analysis (unstandardized B coefficient, 95% CI), age (-0.159, -0.188; -0.129), sex (-9.262, -10.459; -8.064), height (0.417, 0.357; 0.478), lower arm circumference (1.003, 0.736; 1.270), and calf circumference (-0.162, -0.309; -0.015) were significantly associated with HGS.</p><p><strong>Conclusions: </strong>When detecting sarcopenia using HGS, it is important to take into account variables such as body height and body circumference.</p>","PeriodicalId":14933,"journal":{"name":"Journal of Aging Research","volume":"2023 ","pages":"6272743"},"PeriodicalIF":4.7,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10243948/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9600052","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Age- and Gender-Related Differences in Renal Vascular Responses to Angiotensin II in Rats: The Role of the Mas Receptor.","authors":"Fatemeh Eshraghi-Jazi,&nbsp;Mehdi Nematbakhsh","doi":"10.1155/2023/3560468","DOIUrl":"https://doi.org/10.1155/2023/3560468","url":null,"abstract":"<p><strong>Background: </strong>Renal hemodynamic is influenced by both gender difference and age. Also, the Mas receptor (MasR) as one of the depressor components of the renin-angiotensin system which has more expression in females could postpone some dysfunctions associated with age, although the association between MasR and age in renal vascular responses to angiotensin II (Ang II) in male and female rats was well undefined. Therefore, the current study examined the effects of age and sex on systemic and renal vascular responses to graded doses of Ang II in Wistar rats with or without MasR antagonists (A779).</p><p><strong>Materials and methods: </strong>Anesthetized Wistar male and female rats with two age ranges of 8-12 and 24-28 weeks were exposed to cannulate venous and arterial vessels. After stability, mean arterial pressure (MAP), renal perfusion pressure (RPP), renal vascular resistance (RVR), and renal blood flow (RBF) were measured in response to the infusion of Ang II with or without A779.</p><p><strong>Results: </strong>There were no significant differences in the base values of MAP, RPP, RBF, and RVR between the two genders in both the age ranges of 8-12 and 24-28 weeks. In addition, no significant gender difference was observed in the age ranges of the above mentioned parameters among the groups receiving vehicle or A779. Also, the infusion of vehicle or A779 could not significantly change the base values. On the other hand, the responses of RBF and RVR to Ang II revealed gender differences among 8-12-week groups (<i>P</i> < 0.05) but not in 24-28-week groups, while the blockade of MasR could not influence the responses in the age ranges.</p><p><strong>Conclusion: </strong>It was concluded that age could impress sex difference in RBF and RVR responses to Ang II infusion and that MasR alone could not participate in these responses. In other words, MasR is not active under normal and acutely elevated Ang II levels.</p>","PeriodicalId":14933,"journal":{"name":"Journal of Aging Research","volume":"2023 ","pages":"3560468"},"PeriodicalIF":4.7,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10447085/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10127308","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Impact of the COVID-19 Pandemic on the Mental Health of Older Primary Care Patients and Their Family Members","authors":"T. Seibert, Matthew W Schroeder, A. Perkins, Seho Park, Eleanor Batista-Malat, Katharine J. Head, T. Bakas, M. Boustani, Nicole R. Fowler","doi":"10.1155/2022/6909413","DOIUrl":"https://doi.org/10.1155/2022/6909413","url":null,"abstract":"The COVID-19 pandemic introduced mandatory stay-at-home orders and concerns about contracting a virus that impacted the physical and mental health of much of the world's population. This study compared the rates of depression and anxiety in a sample of older primary care patients (aged ≥65 years old) and their family members recruited for a clinical trial before and during the COVID-19 pandemic. Participants were dyads enrolled in the Caregiver Outcomes of Alzheimer's Disease Screening (COADS) trial, which included 1,809 dyads of older primary care patients and one of their family members. Mean scores on the Patient Health Questionnaire-9 (PHQ-9) and the Generalized Anxiety Disorder Scale-7 (GAD-7) were measured and compared before and during the pandemic. We found no difference in depression and anxiety among dyads of older primary care patients and their family members recruited before and during COVID-19. Additionally, we found that older primary care patients and family members who reported their income as comfortable had significantly lower depression and anxiety compared to those who reported having not enough to make ends meet. Along with this, older primary care patients with a high school education or less were more likely to have anxiety compared to those with a postgraduate degree. Moreover, our findings support the notion that certain demographics of older primary care patients and family members are at a higher risk for depression and anxiety, indicating who should be targeted for psychological health interventions that can be adapted during COVID-19. Future research should continue monitoring older primary care patients and their family members through the remainder of the COVID-19 pandemic.","PeriodicalId":14933,"journal":{"name":"Journal of Aging Research","volume":" ","pages":""},"PeriodicalIF":4.7,"publicationDate":"2022-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48779245","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Atherogenic Index of Plasma and Anthropometric Measurements among Osteoporotic Postmenopausal Sudanese Women: Possible Risk for Cardiovascular Disease.","authors":"Abdelgadir Elmugadam, Ghada A Elfadil, Abdalrahman Ismail Hamad, Ahlam Badreldin El Shikieri, Mawahib Aledrissy, Hisham N Altayb","doi":"10.1155/2022/1545127","DOIUrl":"10.1155/2022/1545127","url":null,"abstract":"<p><strong>Introduction: </strong>Data examining the health of menopausal women and the prevalence of osteoporosis remain to be limited in Africa, especially in sub-Saharan countries. Thus, in this current study, we aimed to assess the atherogenic index of plasma (AIP) and anthropometric measurements of osteoporotic postmenopausal women and determine their risk for cardiovascular disease (CVD).</p><p><strong>Methods: </strong>This is a cross-sectional, community-based study. Postmenopausal women (<i>n</i> = 300), aged ≥45 years, were recruited from Khartoum state, Sudan. Dual-energy X-ray absorptiometry was used to assess bone density. Weight, height, and waist circumference were measured twice. Fasting blood samples (5 ml) were collected to determine total cholesterol (TC), triglycerides (TG), low-density lipoprotein cholesterol (LDL-C), and high-density lipoprotein cholesterol (HDL-C). AIP was calculated as an indicator of CVD risk.</p><p><strong>Results: </strong>The mean age of the postmenopausal women was 61.6 ± 10.2 years (range 47-90 years). Women (<i>n</i> = 80) had the normal <i>T</i>-score, and an equal number had osteoporosis (<i>n</i> = 110) and osteopenia (<i>n</i> = 110). The prevalence of osteoporosis was 36.7%. Many postmenopausal women with normal <i>T</i>-scores suffered from general (71.2%) and central (94%) obesity. Postmenopausal women had high TC (24.4%), TG (25.6%), LDL-C (13.7%), and low HDL-C (76.0%) levels. Osteoporotic women (36.4%) were found to have a medium to high risk of CVD as determined by AIP. Women with normal <i>T</i>-scores had a higher number of CVD risk factors. A positive correlation was noted between AIP and TC among osteopenic (<i>r</i> = 0.292; <i>P</i>=0.002) and osteoporotic women (<i>r</i> = 0.265; <i>P</i> < 0.001).</p><p><strong>Conclusion: </strong>Osteoporosis was prevalent among Sudanese postmenopausal women who also had an increased risk for CVD. Public health education about osteoporosis and CVD risk is thus recommended.</p>","PeriodicalId":14933,"journal":{"name":"Journal of Aging Research","volume":"2022 ","pages":"1545127"},"PeriodicalIF":1.6,"publicationDate":"2022-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9529371/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"33488818","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Antiplatelets and Vascular Dementia: A Systematic Review.","authors":"Peter Alexander,&nbsp;Shakthi Visagan,&nbsp;Sara Jawhar,&nbsp;Amogh Kare,&nbsp;Noor Issa,&nbsp;Reem Issa,&nbsp;Abbas Jawhar,&nbsp;Sneha Thomas,&nbsp;Vasavi Gorantla","doi":"10.1155/2022/9780067","DOIUrl":"https://doi.org/10.1155/2022/9780067","url":null,"abstract":"<p><p>Vascular dementia (VD) is a neurocognitive disorder whose precise definition is still up for debate. VD generally refers to dementia that is primarily caused by cerebrovascular disease or impaired cerebral blood flow. It is a subset of vascular cognitive impairment, a class of diseases that relate any cerebrovascular injury as a causal or correlating factor for cognitive decline, most commonly seen in the elderly. Patients who present with both cognitive impairment and clinical or radiologic indications of cerebrovascular pathology should have vascular risk factors, particularly hypertension, examined and treated. While these strategies may be more effective at avoiding dementia than at ameliorating it, there is a compelling case for intensive secondary stroke prevention in these patients. Repeated stroke is related to an increased chance of cognitive decline, and poststroke dementia is connected with an increased risk of death. In general, most physicians follow recommendations for secondary stroke prevention in patients with VD, which can be accomplished by the use of antithrombotic medicines such as antiplatelets (aspirin, clopidogrel, ticlopidine, cilostazol, etc.). In individuals with a high risk of atherosclerosis and those with documented symptomatic cerebrovascular illness, antiplatelets treatment lowers the risk of stroke. While this therapy strategy of prevention and rigorous risk management has a compelling justification, there is only limited and indirect data to support it. The following systematic review examines the role of antiplatelets in the management of vascular dementia in published clinical trials and studies and comments on the current evidence available to support their use and highlights the need for further study.</p>","PeriodicalId":14933,"journal":{"name":"Journal of Aging Research","volume":"2022 ","pages":"9780067"},"PeriodicalIF":4.7,"publicationDate":"2022-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9553722/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"33513395","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Simultaneous Dual-Task Interventions That Improve Cognition in Older Adults: A Scoping Review of Implementation-Relevant Details","authors":"Natasha Versi, K. Murphy, C. Robinson, Mitchell Franklin","doi":"10.1155/2022/6686910","DOIUrl":"https://doi.org/10.1155/2022/6686910","url":null,"abstract":"Cognitive change occurs as a person ages and may result in decreased cognitive functioning in older adults (60 years and older). Simultaneous dual-task (SDT) interventions—activities that require the person to engage physically and cognitively at the same time—are effective in improving cognition in this group. This scoping review analysed published implementation-relevant details about effective SDT interventions, to assist the translation of the available evidence into various practice needs and contexts. A total of 23 databases were searched for relevant studies published between 2009 and 2020 inclusively. Randomised controlled trials (RCTs) that revealed statistically significant improvement in one or more aspects of cognitive function were appraised for methodological quality, using the Joanna Briggs Institute RCT checklist. The 14 RCTs scoring over 50% on the checklist were further analysed. Implementation-relevant data—for example, intervention nature, session length and frequency, equipment and space requirements, target group, and outcomes—were extracted, collated, and synthesised. The effective SDT interventions varied considerably in their nature and outcomes, meaning that suitable SDT interventions exist for a range of contexts. However, the resources required to implement some of the interventions either were not reported and/or may be prohibitive in some real-world practice contexts. Whilst “challenge” and “group interaction” were common features of effective SDT interventions, most studies failed to report on key implementation details required to facilitate translation into practice. It also remains unclear for how long the cognitive benefits are sustained following an effective SDT intervention. In future, more consistent publication of information about how to implement effective SDT interventions, for whom these interventions are engaging/enjoyable, and why would help to translate the available research into improved cognitive outcomes for older adults.","PeriodicalId":14933,"journal":{"name":"Journal of Aging Research","volume":"2022 1","pages":""},"PeriodicalIF":4.7,"publicationDate":"2022-03-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41503704","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between Sarcopenia and Insulin-Like Growth Factor-1, Myostatin, and Insulin Resistance in Elderly Patients Undergoing Hemodialysis","authors":"Novira Widajanti, S. Soelistijo, U. Hadi, M. Thaha, Aditiawardana, Widodo, H. Firdausi, Y. Nurina, MiraDelima Asikin, Hersih Srinowati, N. Syakdiyah","doi":"10.1155/2022/1327332","DOIUrl":"https://doi.org/10.1155/2022/1327332","url":null,"abstract":"Sarcopenia is common in hemodialysis patients, especially in the elderly patients undergoing hemodialysis. Various factors may contribute to the occurrence of sarcopenia, such as anabolic and catabolic imbalance. This study aims to investigate the correlation of insulin-like growth factor-1 (IGF-1) levels as an anabolic factor, myostatin levels, and insulin resistance as catabolic factors with sarcopenia in the pathogenesis of sarcopenia in elderly patients undergoing hemodialysis. A total of 40 subjects aged 60 years or more who undergoing hemodialysis in Dr. Soetomo Hospital Surabaya were included in this cross-sectional study. Sarcopenia was diagnosed according to Asian Working Group Sarcopenia 2019 criteria. IGF-1, myostatin, and insulin resistance levels were measured once before hemodialysis. Subjects with sarcopenia diagnosis were 33 (82.5%), that is, 19 (47.5%) men and 14 (35%) women. There were 28 (70%) of the subjects diagnosed with severe sarcopenia. Furthermore, there were significant differences in the characteristics and geriatric parameters between the sarcopenia and nonsarcopenia groups. There were differences between the two groups in hemoglobin levels, IGF-1 levels, myostatin levels, homeostasis model assessment-insulin resistance (HOMA-IR) levels, muscle mass, handgrip strength, body mass index status, mini nutritional assessment status, and physical activity scale for elderly status (all p < 0.05). Correlation analyses showed that IGF-1 levels negatively correlated with sarcopenia status in elderly patients undergoing hemodialysis (p < 0.05). On the contrary, myostatin and HOMA-IR levels were positively correlated with sarcopenia status in elderly patients undergoing hemodialysis (all p < 0.05). Based on this recent study, IGF-1, myostatin, and insulin resistance were significantly correlated with sarcopenia in elderly patients undergoing hemodialysis.","PeriodicalId":14933,"journal":{"name":"Journal of Aging Research","volume":" ","pages":""},"PeriodicalIF":4.7,"publicationDate":"2022-03-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47592242","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}