Journal of Aging Research最新文献

{"title":"Lack of Intensity Control during an Exercise Program Is Related to a Limited Effect on Variables Responsible for Blood Pressure Regulation in Hypertensive Older Adults.","authors":"Roberta Fernanda da Silva, Thaís Amanda Reia, André Mourão Jacomini, Anderson Bernadino da Silva, Henrique Dos Santos Disessa, Henrique Luiz Monteiro, Anderson Saranz Zago","doi":"10.1155/2024/3128257","DOIUrl":"10.1155/2024/3128257","url":null,"abstract":"<p><p>To compare the effect of an intensity-controlled exercise program (ICEP) and a nonintensity-controlled exercise program (non-ICEP) on the variables responsible for blood pressure regulation in hypertensive older adults. 95 hypertensive older adults (65.40 ± 7.48 years/22 males and 73 females) performed hemodynamic, functional fitness, and biochemical evaluations before and after 12 weeks of the multicomponent exercises which included walking, muscle strength, hydrogymnastics, Pilates, dynamic balance, agility, flexibility, and others. A significant improvement was observed in general functional fitness index (GFFI: <i>p</i> ≤ 0.000, <i>d</i> = 0.35), nitrite (NO₂ ^-: <i>p</i> ≤ 0.000, <i>d</i> = 0.49), systolic blood pressure (SBP: <i>p</i> ≤ 0.000, <i>d</i> = 0.65), diastolic blood pressure (DBP: <i>p</i> ≤ 0.013, <i>d</i> = 0.40), thiobarbituric acid reactive substances (TBARS: <i>p</i> ≤ 0.007, <i>d</i> = 0.78), activity of the endothelial superoxide dismutase enzyme (ecSOD: <i>p</i> ≤ 0.032, <i>d</i> = 0.41), double product (DP: <i>p</i> ≤ 0.015, <i>d</i> = 0.43), and waist-hip ratio (WHR: <i>p</i> ≤ 0.000, <i>d</i> = 0.44) for ICEP. Only GFFI (<i>p</i> ≤ 0.047, <i>d</i> = 0.12), TBARS (<i>p</i> ≤ 0.000, <i>d</i> = 0.77), SOD (<i>p</i> ≤ 0.025, <i>d</i> = 0.25), DP (<i>p</i> ≤ 0.046, <i>d</i> = 0.26), and BMI (<i>p</i> ≤ 0.018, <i>d</i> = 0.02) presented better results in non-ICEP. When the effect of the groups (controlled by age, BMI, and sex) was evaluated, an increase was observed in the NO₂ ^-, TBARS, and SOD and a reduction in the SBP and WHR variables in the ICEP group compared to the non-ICEP group. Twelve weeks of engagement in a controlled-intensity exercise program was enough to improve the level of functional fitness and variables regarding blood pressure regulation in hypertensive older adults. Conversely, physical exercise performed without intensity control was related to the limited effect on such variables.</p>","PeriodicalId":14933,"journal":{"name":"Journal of Aging Research","volume":"2024 ","pages":"3128257"},"PeriodicalIF":1.6,"publicationDate":"2024-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11223912/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141534485","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sleep Quality and Subjective Cognitive Decline among Older Adults: The Mediating Role of Anxiety/Depression and Worries.","authors":"McKenna Sun, Qianqian Zhang, Yifei Han, Jianghong Liu","doi":"10.1155/2024/4946303","DOIUrl":"10.1155/2024/4946303","url":null,"abstract":"<p><strong>Background: </strong>Subjective cognitive decline (SCD) in older individuals has been implicated as a possible precursor to Alzheimer's disease. Poor sleep quality and anxiety/depressive symptoms have been linked to the progression of SCD, but these associations and older adults' worries have yet to be fully established in the Chinese older adult population, which is one of the largest in the world. The aim of this study was to explore the relationship between sleep quality, anxiety/depression symptoms, and worries, and SCD prevalence among Chinese community-dwelling older individuals.</p><p><strong>Methods: </strong>A total of 707 adults aged between 60 and 99 from Shanghai, China, completed self-report questionnaires that covered their cognitive and mental well-being, as well as demographic information. Subjective cognitive decline (SCD) was evaluated using the memory/cognition syndromes of the old adult self-report (OASR). Sleep quality, anxiety/depression, and worries were measured from their respective sections of the OASR.</p><p><strong>Results: </strong>The general linear regression models showed that poorer sleep quality was associated with an increased prevalence of anxiety/depression symptoms, worries, and SCD among older adults. As suggested by the mediation analysis, anxiety/depression and worries were significant mediators in the relationship between sleep quality and SCD prevalence, and these two factors also have a serial mediation effect between sleep quality and SCD prevalence.</p><p><strong>Conclusions: </strong>Poorer sleep quality is associated with a higher rate of SCD among older adults, and a higher prevalence of anxiety/depression and worries mediate this relationship, suggesting possible mechanism pathways that lead to SCD. These factors may provide the basis for early, targeted interventions for older adults' mental health preservation and improved quality of life.</p>","PeriodicalId":14933,"journal":{"name":"Journal of Aging Research","volume":"2024 ","pages":"4946303"},"PeriodicalIF":1.6,"publicationDate":"2024-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11093690/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140921932","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of Mind-Body Qigong Exercise on Overall Health, Fatigue/Sleep, and Cognition in Older Chinese Immigrants in the US: An Intervention Study with Control.","authors":"Jianghong Liu, Yi Yang, Clara Li, Adriana Perez, Adrian Raine, Haoer Shi, Liye Zou","doi":"10.1155/2024/2481518","DOIUrl":"10.1155/2024/2481518","url":null,"abstract":"<p><strong>Background: </strong>Culturally relevant exercises may help improve health and address disparities faced by older immigrants due to language and cultural barriers. Few studies have focused on such exercise interventions among older Chinese immigrants at US daycare centers.</p><p><strong>Methods: </strong>We conducted a 10-week nonrandomized controlled trial in older Chinese immigrants in Philadelphia, US. The intervention group practiced Chinese Qigong (Baduanjin) 5 days a week guided by trained research assistants and video instructions. The control group maintained their usual daily activities. We collected self-report assessments on overall health, sleep, and fatigue and implemented two computerized cognitive tests measuring psychomotor vigilance task (PVT) and memory twice, preintervention and postintervention. Repeated measures general linear model (GLM) and paired samples <i>t</i>-tests were used for data analyses.</p><p><strong>Results: </strong>Eighty-eight older adults (Qigong, <i>n</i> = 53; control, <i>n</i> = 35) with an average age of 78.13 (SD = 5.05) were included. Groups showed no significant differences at baseline evaluation. After the 10-week exercise, the intervention group showed significant improvements in overall health (<i>p</i>=0.032), fatigue (<i>p</i> < 0.001), and cognitive functions including memory (<i>p</i>=0.01), response speed (<i>p</i>=0.002), and response time (<i>p</i>=0.012) on the PVT, as well as marginally significant benefits in sleep (<i>p</i>=0.058). Between-group comparisons identified significant group-by-time interactions in health (<i>p</i>=0.024), sleep (<i>p</i>=0.004), fatigue (<i>p</i>=0.004), and memory (<i>p</i>=0.004).</p><p><strong>Conclusion: </strong>We revealed significant positive effects of Qigong in older Chinese immigrants across multiple health domains. Findings highlight the potential of a culturally relevant exercise in addressing health disparities.</p>","PeriodicalId":14933,"journal":{"name":"Journal of Aging Research","volume":"2024 ","pages":"2481518"},"PeriodicalIF":1.6,"publicationDate":"2024-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10849816/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139706762","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Do-Not-ResuscitateDecision-Making during the COVID-19 Pandemic in a Teaching Hospital: Lessons Learned for the Future","authors":"Mick van de Wiel, Sabrina van Ierssel, Walter Verbrugghe, Veerle Mertens, A. Janssens","doi":"10.1155/2023/2771149","DOIUrl":"https://doi.org/10.1155/2023/2771149","url":null,"abstract":"Rationale. Contribute to the understanding of DNR decision-making and conducting end-of-life conversations, about which there is a paucity of data available in the current literature. Aims and Objectives. Assess how the decision-making process to determine a DNR code is implemented in the day-to-day clinical practice in a tertiary teaching hospital. Familiarity with the use of different scores as a possible objective support for DNR decisions and the influence of various elements on a DNR decision was explored. Method. A cross-sectional survey study was conducted between February 2021 and April 2021 for all doctors and doctors in training, working in the Antwerp University Hospital during the COVID-19 pandemic. Results. 127 doctors participated in this study. The familiarity with the different scores used in the triage during the COVID-10 pandemic was 51% for the Clinical Frailty Scale (CFS) and 20% for the Charlson Comorbidity Index (CCI). Participants indicated that their DNR decision is based on various aspects such as clinical assessment, comorbidities, patient’s wishes, age, prognosis, and functional state. Conclusion. The familiarity with the different scores used during triage assessments is low. The total clinical picture of the patient is needed to make a considered decision, and this total picture of the patient seems to be well encompassed by frailty measurement (CFS). Although many participants indicated that the different scores do not offer much added value compared to their clinical assessment, it can help guide DNR decisions, especially for doctors in training.","PeriodicalId":14933,"journal":{"name":"Journal of Aging Research","volume":"10 9","pages":""},"PeriodicalIF":4.7,"publicationDate":"2023-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138955990","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Health Service Utilization and Its Determinants among Senior Citizens in the Semiurban Area of Western Nepal: A Cross-Sectional Study","authors":"Yamuna Chhetri, Dhurba Khatri, N. Gahatraj","doi":"10.1155/2023/3655259","DOIUrl":"https://doi.org/10.1155/2023/3655259","url":null,"abstract":"Background. Senior citizens are usually infected by multiple chronic conditions and other health problems. Health needs and demand for healthcare services increase with age. However, healthcare services and facilities and their utilization are limited, particularly in developing countries. Aims. To identify the utilization of health services among senior citizens and their contributing factors. Methods. A cross-sectional analytic study was conducted among 293 senior citizens of the Kushma municipality, Nepal, from June to December 2019. A structured questionnaire was used as a data collection tool using a multistage sampling technique. Face-to-face interviews were conducted to collect data on the interview schedule. Reliability and validity were maintained by applying different strategies and carefully developing tools, pretesting, double entry, and validation. Data entry, management, and analysis were performed using Epi Data and SPSS software. Research ethics were maintained. Descriptive and inferential statistical tests were performed to infer the findings. Results. Study participants had a mean age (±SD) of 70.08 (±7.6) years and had various preexisting chronic diseases such as hypertension (46%), gastritis (41.9%), arthritis (34.3%), and asthma (28.7%). Only eight out of ten senior citizens had used health services in the past year. Factors such as age, ethnicity, residency, household income, family support, the presence of chronic diseases, and being under medication were found to have statistically significant associations with the utilization of health services among senior citizens with a \u0000 \u0000 p\u0000 \u0000 value less than 0.05 and 95% confidence interval. Conclusions. A remarkable proportion of older people reported using health services in the last year. However, a substantial proportion did not utilize health services that require further interventions to enable them. Efforts are required to promote the health and well-being of Nepal’s growing elderly population, including potential enhancements to rural healthcare infrastructure by policymakers.","PeriodicalId":14933,"journal":{"name":"Journal of Aging Research","volume":" 917","pages":""},"PeriodicalIF":4.7,"publicationDate":"2023-12-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138960284","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Melamine Exacerbates Neurotoxicity in D-Galactose-Induced Neuronal SH-SY5Y Cells.","authors":"Juhi Goyal, Preet Jain, Vivek Jain, Dibyajyoti Banerjee, Rajasri Bhattacharyya, Sharmistha Dey, Rambabu Sharma, Nitish Rai","doi":"10.1155/2023/6635370","DOIUrl":"10.1155/2023/6635370","url":null,"abstract":"<p><p>Numerous studies have depicted the role of diet and environmental toxins in aging. Melamine (Mel) is a globally known notorious food adulterant, and its toxicity has been shown in several organs including the brain. However, till now, there are no reports regarding Mel neurotoxicity in aging neurons. So, this study examined the <i>in vitro</i> neurotoxicity caused by Mel in the D-galactose (DG)-induced aging model of neuronal SH-SY5Y cells. In the present study, the neuronal SH-SY5Y cells were treated with DG and Mel separately and in combination to assess the neurotoxicity potential using MTT assay and neurite length measurement. Further, the superoxide dismutase (SOD), catalase (CAT), and total antioxidant activities were evaluated followed by the determination of the intracellular reactive oxygen species (ROS), mitochondrial membrane potential (MMP), and caspase3 (Casp3) activity. The cotreatment of Mel and DG in neuronal SH-SY5Y cells showed maximum cell death than the cells treated with DG or Mel individually and untreated control cells. The neurite length shrinkage and ROS production were maximum in the DG and Mel cotreated cells showing exacerbated toxicity of Mel. The activity of SOD, CAT, and total antioxidants was also found to be lowered in the cotreatment group (Mel + DG) than in Mel- or DG-treated and untreated cells. Further, the combined toxicity of Mel and DG also elevated the Casp3 activity more than any other group. This is the first study showing the increased neurotoxic potential of Mel in an aging model of neuronal SH-SY5Y cells which implicates that Mel consumption by the elderly may lead to increased incidences of neurodegeneration like Alzheimer's disease and Parkinson's disease.</p>","PeriodicalId":14933,"journal":{"name":"Journal of Aging Research","volume":"2023 ","pages":"6635370"},"PeriodicalIF":4.7,"publicationDate":"2023-11-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10689074/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138477739","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Examining Outcomes and Challenges of Telepsychiatry in Australian Elderly: A Scoping Review.","authors":"Sodabeh Abazari, Khadijeh Moulaei, Manoj George","doi":"10.1155/2023/8864591","DOIUrl":"10.1155/2023/8864591","url":null,"abstract":"<p><strong>Methods: </strong>To find relevant articles, we searched PubMed, Scopus, and Web of Science databases. We used a data extraction form to gather information from primary studies. Two researchers followed inclusion and exclusion criteria to select studies and extract data. Disagreements were resolved through discussion with all researchers. Studies needed to be in English, about telepsychiatry for Australian seniors, and use any technology type (synchronous, asynchronous, or both). We excluded nontelepsychiatry articles, books, book chapters, conference abstracts, and editor letters.</p><p><strong>Results: </strong>Telepsychiatry was effectively employed to manage depression, anxiety, delirium, and cognitive impairments. Among these four disorders, telepsychiatry was mostly used for depression. Videoconference and telephone were mostly used to provide telepsychiatry services. Most telepsychiatry services for Australian seniors included \"patient education on disorder control and management,\" \"creating continuous interaction between the patient and the therapist,\" and \"remote patients' assessment.\" \"Reductions in symptoms of disorders,\" \"improving patients' satisfaction with telepsychiatry,\" and \"cost-effectiveness of telepsychiatry\" were the most important positive outcomes of using telepsychiatry. We also identified four challenges in using telepsychiatry for elderly individuals in Australia.</p><p><strong>Conclusions: </strong>This study is the first scoping review in Australia and provides valuable insight into telepsychiatry for elderly individuals.</p>","PeriodicalId":14933,"journal":{"name":"Journal of Aging Research","volume":"2023 ","pages":"8864591"},"PeriodicalIF":1.6,"publicationDate":"2023-10-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10597727/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"50161696","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Cost-Benefit of Aging: Financial Capability and Well-Being across Age Groups in Brazil.","authors":"Eduarda A S R G da Silva,&nbsp;César A T Silva","doi":"10.1155/2023/2020189","DOIUrl":"https://doi.org/10.1155/2023/2020189","url":null,"abstract":"<p><p>A large proportion of older persons in developing countries do not have access to pension, which also constrains their ability to afford healthcare services and entails extensive challenges to the well-being of older people. This study aimed to analyze the financial preparedness of different age groups for retirement in Brazil. Data were derived from a survey to empirically validate the proposed relationships between <i>preparedness for retirement</i> and <i>resilience for the future</i> (financial well-being (FWB) outcomes) on the one hand and among <i>demographic and socioeconomic</i> aspects, <i>behaviors and attitudes</i>, <i>knowledge and experience</i>, and \"key\" <i>psychological factors</i> on the other hand. The sample consisted of 412 individuals aged between 22 and 79 years. FWB was measured using the financial capability and well-being model and regressed on a number of sociodemographic and psychological variables using linear regression analyses. The results demonstrated that <i>preparedness for retirement</i> was strongly related to older age. Additionally, age was correlated with <i>resilience for the future</i> close to zero, which indicates no relationship. <i>Knowledge</i> and the <i>psychological factors</i> of self-control and confidence were positively and strongly related to better <i>financial behavior</i> for all age groups. In addition, g<i>rit</i> and <i>resilience for the future</i> were positively related to better <i>financial behavior</i> in the older age group. Furthermore, the variables of retirement contribution were seemingly not viewed as important to the older group compared with their young and mature counterparts. Multidimensional interventions, especially targeting <i>behaviors</i> and <i>psychological</i> patterns, could, therefore, be recommended in advance to young and mature groups to prepare them to secure their old age and achieve FWB.</p>","PeriodicalId":14933,"journal":{"name":"Journal of Aging Research","volume":"2023 ","pages":"2020189"},"PeriodicalIF":4.7,"publicationDate":"2023-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10581847/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49677683","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Association between Delirium and In-Hospital Falls: A Cross-Sectional Analysis of a Delirium Screening Program.","authors":"Benjamin Kalivas,&nbsp;Jingwen Zhang,&nbsp;Kristine Harper,&nbsp;Meghan K Thomas,&nbsp;Jennifer Dulin,&nbsp;Justin Marsden,&nbsp;Patrick Robbins,&nbsp;Kelly J Hunt,&nbsp;Patrick D Mauldin,&nbsp;William P Moran,&nbsp;James Rudolph,&nbsp;Marc Heincelman","doi":"10.1155/2023/1562773","DOIUrl":"https://doi.org/10.1155/2023/1562773","url":null,"abstract":"<p><strong>Methods: </strong>A cross-sectional study using delirium screening and falls reports was used to measure the association between delirium and falls. All inpatient data from August, 2018, to January, 2020, at a large academic medical center were analyzed. A multivariable logistic regression of 29,655 hospital admissions was used to understand the association between in-hospital delirium and falls.</p><p><strong>Results: </strong>Analysis revealed a delirium rate of 12.5% (<i>n</i> = 3,707) of all admissions and 286 (0.9%) admissions with falls; of the falls studied, 37.6% of these patients screened positive for delirium during their admission. Relative to those who screened negative for delirium, admissions that screened positive for delirium had a 2.81 increased odds of falling.</p><p><strong>Conclusions: </strong>Delirium and falls are related. This strong association should motivate health systems to look closely at both problems. Falls and delirium can both have immense impacts on the patient and the health system. The powerful association between them provides a window to reduce these additional patient harms. More specifically, a modern delirium screening tool should be used as part of routine risk assessment focused on reducing in-hospital falls.</p>","PeriodicalId":14933,"journal":{"name":"Journal of Aging Research","volume":"2023 ","pages":"1562773"},"PeriodicalIF":4.7,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9902156/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10689125","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"MAOA uVNTR Polymorphism Influence on Older Adults Diagnosed with Diabetes Mellitus/Systemic Arterial Hypertension.","authors":"Gabriel Moura Alves Seixas,&nbsp;Renata de Souza Freitas,&nbsp;Caroline Ferreira Fratelli,&nbsp;Calliandra Maria de Souza Silva,&nbsp;Luciano Ramos de Lima,&nbsp;Marina Morato Stival,&nbsp;Silvana Schwerz Funghetto,&nbsp;Izabel Cristina Rodrigues da Silva","doi":"10.1155/2023/8538027","DOIUrl":"https://doi.org/10.1155/2023/8538027","url":null,"abstract":"<p><strong>Background: </strong>Monoamine oxidase (MAO) is involved in several biological processes associated with well-being and mental health, and alterations in its function might directly impact various mental disorders. Some mental disorders concomitantly occur in individuals with clinical characteristics, such as substance abuse and diabetes.</p><p><strong>Objective: </strong>To analyze the functional MAOA uVNTR polymorphism genotype frequency in an older adult population with diabetes mellitus/arterial hypertension and associate this frequency with clinical characteristics impacting daily life. <i>Methodology</i>. Older adults diagnosed with diabetes mellitus, systemic arterial hypertension, or both (DM/SAH) were selected and had their MAOA gene genotyped for uVNTR polymorphism. The revised Beck Depression Inventory (BDI) and a questionnaire were also applied to determine their mental health and clinical characteristics.</p><p><strong>Results: </strong>The allelic variants detected among the participants were the 2R, 3R, 4R, and 3R/4R heterozygous genotypes. Genotypes solely containing the 3R allele had patients who marked yes for smoking and alcoholism, and only those with the 3R genotypes (female 3R/3R homozygote or male 3R^<i>∗</i> hemizygote) were significant. Although not statistically significant, only 3R and 3R/4R genotypes presented cases of severe depression per the revised BDI interpretations.</p><p><strong>Conclusion: </strong>The MAOA uVNTR polymorphism's low-activity 3R allele presence in an older adult population diagnosed with DM/SAH may represent a risk for developing substance use (alcohol and smoking) dependence.</p>","PeriodicalId":14933,"journal":{"name":"Journal of Aging Research","volume":"2023 ","pages":"8538027"},"PeriodicalIF":4.7,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10393510/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9930350","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}