Journal of Aging Research最新文献

{"title":"Anthropometric and Body Circumference Determinants for Hand Grip Strength: A Population-Based Mon-Timeline Study.","authors":"Agiimaa Byambaa,&nbsp;Indra Altankhuyag,&nbsp;Otgonbayar Damdinbazar,&nbsp;Tsolmon Jadamba,&nbsp;Oyuntugs Byambasukh","doi":"10.1155/2023/6272743","DOIUrl":"https://doi.org/10.1155/2023/6272743","url":null,"abstract":"<p><strong>Background: </strong>Hand grip strength (HGS) is a tool for diagnosing sarcopenia. In this study, we examined some anthropometric and body circumference measurements as determinants for HGS.</p><p><strong>Methods: </strong>This cross-sectional study was conducted with participants (Mongolians, <i>n</i> = 1080, aged 18-70, mean age of 41.2 ± 13.9 years, 33.7% of men) from the \"Mon-Timeline\" cohort study. To measure HGS, a digital grip strength dynamometer was used.</p><p><strong>Results: </strong>Mean HGS in men was 40.1 ± 10.4 kg and in women was 24.5 ± 5.6 kg. Correlation analysis showed that the strongest correlation with HGS was height (<i>r</i> = 0.712, <i>p</i> < 0.001). Moreover, HGS was inversely correlated with age (<i>r</i> = -0.239, <i>p</i> < 0.001) and thigh circumference (<i>r</i> = -0.070, <i>p</i> < 0.01), while it was positively correlated with body weight (<i>r</i> = 0.309, <i>p</i> < 0.001), neck circumference (<i>r</i> = 0.427, <i>p</i> < 0.001), upper arm circumference (<i>r</i> = 0.108, <i>p</i> < 0.0001), lower arm circumference (<i>r</i> = 0.413, <i>p</i> < 0.0001), and calf circumference (<i>r</i> = 0.117, <i>p</i> < 0.0001). In the multivariate linear regression analysis (unstandardized B coefficient, 95% CI), age (-0.159, -0.188; -0.129), sex (-9.262, -10.459; -8.064), height (0.417, 0.357; 0.478), lower arm circumference (1.003, 0.736; 1.270), and calf circumference (-0.162, -0.309; -0.015) were significantly associated with HGS.</p><p><strong>Conclusions: </strong>When detecting sarcopenia using HGS, it is important to take into account variables such as body height and body circumference.</p>","PeriodicalId":14933,"journal":{"name":"Journal of Aging Research","volume":"2023 ","pages":"6272743"},"PeriodicalIF":4.7,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10243948/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9600052","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Age- and Gender-Related Differences in Renal Vascular Responses to Angiotensin II in Rats: The Role of the Mas Receptor.","authors":"Fatemeh Eshraghi-Jazi,&nbsp;Mehdi Nematbakhsh","doi":"10.1155/2023/3560468","DOIUrl":"https://doi.org/10.1155/2023/3560468","url":null,"abstract":"<p><strong>Background: </strong>Renal hemodynamic is influenced by both gender difference and age. Also, the Mas receptor (MasR) as one of the depressor components of the renin-angiotensin system which has more expression in females could postpone some dysfunctions associated with age, although the association between MasR and age in renal vascular responses to angiotensin II (Ang II) in male and female rats was well undefined. Therefore, the current study examined the effects of age and sex on systemic and renal vascular responses to graded doses of Ang II in Wistar rats with or without MasR antagonists (A779).</p><p><strong>Materials and methods: </strong>Anesthetized Wistar male and female rats with two age ranges of 8-12 and 24-28 weeks were exposed to cannulate venous and arterial vessels. After stability, mean arterial pressure (MAP), renal perfusion pressure (RPP), renal vascular resistance (RVR), and renal blood flow (RBF) were measured in response to the infusion of Ang II with or without A779.</p><p><strong>Results: </strong>There were no significant differences in the base values of MAP, RPP, RBF, and RVR between the two genders in both the age ranges of 8-12 and 24-28 weeks. In addition, no significant gender difference was observed in the age ranges of the above mentioned parameters among the groups receiving vehicle or A779. Also, the infusion of vehicle or A779 could not significantly change the base values. On the other hand, the responses of RBF and RVR to Ang II revealed gender differences among 8-12-week groups (<i>P</i> < 0.05) but not in 24-28-week groups, while the blockade of MasR could not influence the responses in the age ranges.</p><p><strong>Conclusion: </strong>It was concluded that age could impress sex difference in RBF and RVR responses to Ang II infusion and that MasR alone could not participate in these responses. In other words, MasR is not active under normal and acutely elevated Ang II levels.</p>","PeriodicalId":14933,"journal":{"name":"Journal of Aging Research","volume":"2023 ","pages":"3560468"},"PeriodicalIF":4.7,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10447085/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10127308","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Impact of the COVID-19 Pandemic on the Mental Health of Older Primary Care Patients and Their Family Members","authors":"T. Seibert, Matthew W Schroeder, A. Perkins, Seho Park, Eleanor Batista-Malat, Katharine J. Head, T. Bakas, M. Boustani, Nicole R. Fowler","doi":"10.1155/2022/6909413","DOIUrl":"https://doi.org/10.1155/2022/6909413","url":null,"abstract":"The COVID-19 pandemic introduced mandatory stay-at-home orders and concerns about contracting a virus that impacted the physical and mental health of much of the world's population. This study compared the rates of depression and anxiety in a sample of older primary care patients (aged ≥65 years old) and their family members recruited for a clinical trial before and during the COVID-19 pandemic. Participants were dyads enrolled in the Caregiver Outcomes of Alzheimer's Disease Screening (COADS) trial, which included 1,809 dyads of older primary care patients and one of their family members. Mean scores on the Patient Health Questionnaire-9 (PHQ-9) and the Generalized Anxiety Disorder Scale-7 (GAD-7) were measured and compared before and during the pandemic. We found no difference in depression and anxiety among dyads of older primary care patients and their family members recruited before and during COVID-19. Additionally, we found that older primary care patients and family members who reported their income as comfortable had significantly lower depression and anxiety compared to those who reported having not enough to make ends meet. Along with this, older primary care patients with a high school education or less were more likely to have anxiety compared to those with a postgraduate degree. Moreover, our findings support the notion that certain demographics of older primary care patients and family members are at a higher risk for depression and anxiety, indicating who should be targeted for psychological health interventions that can be adapted during COVID-19. Future research should continue monitoring older primary care patients and their family members through the remainder of the COVID-19 pandemic.","PeriodicalId":14933,"journal":{"name":"Journal of Aging Research","volume":" ","pages":""},"PeriodicalIF":4.7,"publicationDate":"2022-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48779245","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Atherogenic Index of Plasma and Anthropometric Measurements among Osteoporotic Postmenopausal Sudanese Women: Possible Risk for Cardiovascular Disease.","authors":"Abdelgadir Elmugadam, Ghada A Elfadil, Abdalrahman Ismail Hamad, Ahlam Badreldin El Shikieri, Mawahib Aledrissy, Hisham N Altayb","doi":"10.1155/2022/1545127","DOIUrl":"10.1155/2022/1545127","url":null,"abstract":"<p><strong>Introduction: </strong>Data examining the health of menopausal women and the prevalence of osteoporosis remain to be limited in Africa, especially in sub-Saharan countries. Thus, in this current study, we aimed to assess the atherogenic index of plasma (AIP) and anthropometric measurements of osteoporotic postmenopausal women and determine their risk for cardiovascular disease (CVD).</p><p><strong>Methods: </strong>This is a cross-sectional, community-based study. Postmenopausal women (<i>n</i> = 300), aged ≥45 years, were recruited from Khartoum state, Sudan. Dual-energy X-ray absorptiometry was used to assess bone density. Weight, height, and waist circumference were measured twice. Fasting blood samples (5 ml) were collected to determine total cholesterol (TC), triglycerides (TG), low-density lipoprotein cholesterol (LDL-C), and high-density lipoprotein cholesterol (HDL-C). AIP was calculated as an indicator of CVD risk.</p><p><strong>Results: </strong>The mean age of the postmenopausal women was 61.6 ± 10.2 years (range 47-90 years). Women (<i>n</i> = 80) had the normal <i>T</i>-score, and an equal number had osteoporosis (<i>n</i> = 110) and osteopenia (<i>n</i> = 110). The prevalence of osteoporosis was 36.7%. Many postmenopausal women with normal <i>T</i>-scores suffered from general (71.2%) and central (94%) obesity. Postmenopausal women had high TC (24.4%), TG (25.6%), LDL-C (13.7%), and low HDL-C (76.0%) levels. Osteoporotic women (36.4%) were found to have a medium to high risk of CVD as determined by AIP. Women with normal <i>T</i>-scores had a higher number of CVD risk factors. A positive correlation was noted between AIP and TC among osteopenic (<i>r</i> = 0.292; <i>P</i>=0.002) and osteoporotic women (<i>r</i> = 0.265; <i>P</i> < 0.001).</p><p><strong>Conclusion: </strong>Osteoporosis was prevalent among Sudanese postmenopausal women who also had an increased risk for CVD. Public health education about osteoporosis and CVD risk is thus recommended.</p>","PeriodicalId":14933,"journal":{"name":"Journal of Aging Research","volume":"2022 ","pages":"1545127"},"PeriodicalIF":1.6,"publicationDate":"2022-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9529371/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"33488818","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Antiplatelets and Vascular Dementia: A Systematic Review.","authors":"Peter Alexander,&nbsp;Shakthi Visagan,&nbsp;Sara Jawhar,&nbsp;Amogh Kare,&nbsp;Noor Issa,&nbsp;Reem Issa,&nbsp;Abbas Jawhar,&nbsp;Sneha Thomas,&nbsp;Vasavi Gorantla","doi":"10.1155/2022/9780067","DOIUrl":"https://doi.org/10.1155/2022/9780067","url":null,"abstract":"<p><p>Vascular dementia (VD) is a neurocognitive disorder whose precise definition is still up for debate. VD generally refers to dementia that is primarily caused by cerebrovascular disease or impaired cerebral blood flow. It is a subset of vascular cognitive impairment, a class of diseases that relate any cerebrovascular injury as a causal or correlating factor for cognitive decline, most commonly seen in the elderly. Patients who present with both cognitive impairment and clinical or radiologic indications of cerebrovascular pathology should have vascular risk factors, particularly hypertension, examined and treated. While these strategies may be more effective at avoiding dementia than at ameliorating it, there is a compelling case for intensive secondary stroke prevention in these patients. Repeated stroke is related to an increased chance of cognitive decline, and poststroke dementia is connected with an increased risk of death. In general, most physicians follow recommendations for secondary stroke prevention in patients with VD, which can be accomplished by the use of antithrombotic medicines such as antiplatelets (aspirin, clopidogrel, ticlopidine, cilostazol, etc.). In individuals with a high risk of atherosclerosis and those with documented symptomatic cerebrovascular illness, antiplatelets treatment lowers the risk of stroke. While this therapy strategy of prevention and rigorous risk management has a compelling justification, there is only limited and indirect data to support it. The following systematic review examines the role of antiplatelets in the management of vascular dementia in published clinical trials and studies and comments on the current evidence available to support their use and highlights the need for further study.</p>","PeriodicalId":14933,"journal":{"name":"Journal of Aging Research","volume":"2022 ","pages":"9780067"},"PeriodicalIF":4.7,"publicationDate":"2022-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9553722/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"33513395","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Simultaneous Dual-Task Interventions That Improve Cognition in Older Adults: A Scoping Review of Implementation-Relevant Details.","authors":"Natasha Versi, Kylie Murphy, Caroline Robinson, Mitchell Franklin","doi":"10.1155/2022/6686910","DOIUrl":"10.1155/2022/6686910","url":null,"abstract":"<p><p>Cognitive change occurs as a person ages and may result in decreased cognitive functioning in older adults (60 years and older). Simultaneous dual-task (SDT) interventions-activities that require the person to engage physically and cognitively at the same time-are effective in improving cognition in this group. This scoping review analysed published implementation-relevant details about effective SDT interventions, to assist the translation of the available evidence into various practice needs and contexts. A total of 23 databases were searched for relevant studies published between 2009 and 2020 inclusively. Randomised controlled trials (RCTs) that revealed statistically significant improvement in one or more aspects of cognitive function were appraised for methodological quality, using the Joanna Briggs Institute RCT checklist. The 14 RCTs scoring over 50% on the checklist were further analysed. Implementation-relevant data-for example, intervention nature, session length and frequency, equipment and space requirements, target group, and outcomes-were extracted, collated, and synthesised. The effective SDT interventions varied considerably in their nature and outcomes, meaning that suitable SDT interventions exist for a range of contexts. However, the resources required to implement some of the interventions either were not reported and/or may be prohibitive in some real-world practice contexts. Whilst \"challenge\" and \"group interaction\" were common features of effective SDT interventions, most studies failed to report on key implementation details required to facilitate translation into practice. It also remains unclear for how long the cognitive benefits are sustained following an effective SDT intervention. In future, more consistent publication of information about how to implement effective SDT interventions, for whom these interventions are engaging/enjoyable, and why would help to translate the available research into improved cognitive outcomes for older adults.</p>","PeriodicalId":14933,"journal":{"name":"Journal of Aging Research","volume":"2022 1","pages":"6686910"},"PeriodicalIF":1.6,"publicationDate":"2022-03-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8983262/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41503704","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between Sarcopenia and Insulin-Like Growth Factor-1, Myostatin, and Insulin Resistance in Elderly Patients Undergoing Hemodialysis","authors":"Novira Widajanti, S. Soelistijo, U. Hadi, M. Thaha, Aditiawardana, Widodo, H. Firdausi, Y. Nurina, MiraDelima Asikin, Hersih Srinowati, N. Syakdiyah","doi":"10.1155/2022/1327332","DOIUrl":"https://doi.org/10.1155/2022/1327332","url":null,"abstract":"Sarcopenia is common in hemodialysis patients, especially in the elderly patients undergoing hemodialysis. Various factors may contribute to the occurrence of sarcopenia, such as anabolic and catabolic imbalance. This study aims to investigate the correlation of insulin-like growth factor-1 (IGF-1) levels as an anabolic factor, myostatin levels, and insulin resistance as catabolic factors with sarcopenia in the pathogenesis of sarcopenia in elderly patients undergoing hemodialysis. A total of 40 subjects aged 60 years or more who undergoing hemodialysis in Dr. Soetomo Hospital Surabaya were included in this cross-sectional study. Sarcopenia was diagnosed according to Asian Working Group Sarcopenia 2019 criteria. IGF-1, myostatin, and insulin resistance levels were measured once before hemodialysis. Subjects with sarcopenia diagnosis were 33 (82.5%), that is, 19 (47.5%) men and 14 (35%) women. There were 28 (70%) of the subjects diagnosed with severe sarcopenia. Furthermore, there were significant differences in the characteristics and geriatric parameters between the sarcopenia and nonsarcopenia groups. There were differences between the two groups in hemoglobin levels, IGF-1 levels, myostatin levels, homeostasis model assessment-insulin resistance (HOMA-IR) levels, muscle mass, handgrip strength, body mass index status, mini nutritional assessment status, and physical activity scale for elderly status (all p < 0.05). Correlation analyses showed that IGF-1 levels negatively correlated with sarcopenia status in elderly patients undergoing hemodialysis (p < 0.05). On the contrary, myostatin and HOMA-IR levels were positively correlated with sarcopenia status in elderly patients undergoing hemodialysis (all p < 0.05). Based on this recent study, IGF-1, myostatin, and insulin resistance were significantly correlated with sarcopenia in elderly patients undergoing hemodialysis.","PeriodicalId":14933,"journal":{"name":"Journal of Aging Research","volume":" ","pages":""},"PeriodicalIF":4.7,"publicationDate":"2022-03-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47592242","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Investigating Relationships between Balance Confidence and Balance Ability in Older Adults.","authors":"Lara A Thompson,&nbsp;Mehdi Badache,&nbsp;Joao Augusto Renno Brusamolin,&nbsp;Marzieh Savadkoohi,&nbsp;Jelani Guise,&nbsp;Gabriel Velluto de Paiva,&nbsp;Pius Suh,&nbsp;Pablo Sanchez Guerrero,&nbsp;Devdas Shetty","doi":"10.1155/2021/3214366","DOIUrl":"https://doi.org/10.1155/2021/3214366","url":null,"abstract":"<p><p>Increasing balance confidence in older individuals is important towards improving their quality of life and reducing activity avoidance. Here, we investigated if balance confidence (perceived ability) and balance performance (ability) in older adults were related to one another and would improve after balance training. The relationship of balance confidence in conjunction with balance performance for varied conditions (such as limiting vision, modifying somatosensory cues, and also base of support) was explored. We sought to determine if balance confidence and ability, as well as their relationship, could change after several weeks of training. Twenty-seven healthy participants were trained for several weeks during standing and walking exercises. In addition, seven participants with a higher risk of imbalance leading to falls (survivors of stroke) were also trained. Prior to and after training, balance ability and confidence were assessed via the Balance Error Scoring System (BESS) and Activities Specific Balance Confidence (ABC) Scale, respectively. Both groups showed improvements in balance abilities (i.e., BESS errors significantly decreased after training). Balance confidence was significantly higher in the healthy group than in the stroke group; however, ABC results reflected that balance confidence did not significantly increase after training for each. The correlations between balance ability and balance confidence were explored. Encouragingly, healthy participants displayed a negative correlation between BESS errors and ABC (i.e., enhancements in balance confidence (increases in ABC Scale results) were related to improvements in balance ability (decreases in BESS errors)). For the stroke participants, despite improvements in balance ability, our results showed that there was no relation to balance confidence (i.e., no correlation between BESS errors and ABC) in this group.</p>","PeriodicalId":14933,"journal":{"name":"Journal of Aging Research","volume":"2021 ","pages":"3214366"},"PeriodicalIF":4.7,"publicationDate":"2021-11-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8642018/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39948036","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Survey of Knee Osteoarthritis in the Population over Age 50 Visited in the Health Bus in Kermanshah, Iran.","authors":"MohammadBagher Shamsi,&nbsp;Ameneh Safari,&nbsp;Ali Soroush,&nbsp;Yahya Safari","doi":"10.1155/2021/9809565","DOIUrl":"https://doi.org/10.1155/2021/9809565","url":null,"abstract":"<p><p>Along with an aging population worldwide, knee osteoarthritis (KOA), which is the main cause of musculoskeletal pain and disability in the elderly and decreases the quality of life, is prevalent, and their impact is widespread. This study aimed to evaluate the knee osteoarthritis status among the population over age 50 in Kermanshah, Iran. The research community consisted of the population who has been visited in the health bus in Kermanshah in 2016-2017, of which 589 were chosen by an available sampling method. A WOMAC questionnaire was used to determine the prevalence of knee osteoarthritis. The prevalence of knee stiffness rate after sitting, lying down, or resting during the day among women and men were 40.7% and 20.5%, respectively. According to the findings, the highest prevalence rate of knee pain was in subjects with a BMI higher than 30 (31.6%) and BMI 25-30 (24.5%). 39.2% of the subjects never experienced knee pain, 16.6% monthly, 13.4% once a week, 20.4% daily, and 10.4% of them had prolonged knee pain experience. The prevalence of gender-based knee pain was 60.5% among women and 38.6% among men. 30.5% of women and 61.4% of men never experienced knee pain.</p>","PeriodicalId":14933,"journal":{"name":"Journal of Aging Research","volume":"2021 ","pages":"9809565"},"PeriodicalIF":4.7,"publicationDate":"2021-11-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8604593/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39644412","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"UVA Exposure Combined with Glycation of the Dermis Are Two Catalysts for Skin Aging and Promotes a Favorable Environment to the Appearance of Elastosis.","authors":"Hervé Pageon,&nbsp;Hélène Zucchi,&nbsp;Sylvie Ricois,&nbsp;Philippe Bastien,&nbsp;Daniel Asselineau","doi":"10.1155/2021/6647773","DOIUrl":"https://doi.org/10.1155/2021/6647773","url":null,"abstract":"<p><p>Skin aging is the result of superimposed intrinsic (individual) and extrinsic (e.g., UV exposure or nutrition) aging. Previous works have reported a relationship between UV irradiation and glycation in the aging process, leading, for example, to modified radical species production and the appearance of AGEs (advanced glycosylation end products) in increasing quantities, particularly glycoxidation products like pentosidine. In addition, the colocalization of AGEs and elastosis has also been observed. We first investigated the combination of the glycation reaction and UVA effects on a reconstructed skin model to explain their cumulative biological effect. We found that UVA exposure combined with glycation had the ability to intensify the response for specific markers: for example, MMP1 or MMP3 mRNA, proteases involved in extracellular matrix degradation, or proinflammatory cytokine, IL1<i>α</i>, protein expression. Moreover, the association of glycation and UVA irradiation is believed to promote an environment that favors the onset of an elastotic-like phenomenon: mRNA coding for elastin, elastase, and tropoelastin expression is increased. Secondly, because the damaging effects of UV radiation <i>in vivo</i> might be more detrimental in aged skin than in young skin due to increased accumulation of pentosidine and the exacerbation of alterations related to chronological aging, we studied the biological effect of soluble pentosidine in fibroblasts grown in monolayers. We found that pentosidine induced upregulation of CXCL2, IL8, and MMP12 mRNA expression (inflammatory and elastotic markers, respectively). Tropoelastin protein expression (elastin precursor) was also increased. In conclusion, fibroblasts in monolayers cultured with soluble pentosidine and tridimensional <i>in vitro</i> skin constructs exposed to the combination of AGEs and UVA promote an inflammatory state and an alteration of the dermal compartment in relation to an elastosis-like environment.</p>","PeriodicalId":14933,"journal":{"name":"Journal of Aging Research","volume":"2021 ","pages":"6647773"},"PeriodicalIF":4.7,"publicationDate":"2021-10-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8563119/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39592227","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}