Journal of Aging Research最新文献

{"title":"Genetic, Socioecological, and Health Research on Extreme Longevity in Semisupercentenarians and Supercentenarians: A Scoping Review.","authors":"Omnia Abdelraheem, Wafa Abu El Kheir-Mataria, Sungsoo Chun","doi":"10.1155/jare/1605361","DOIUrl":"10.1155/jare/1605361","url":null,"abstract":"<p><strong>Objective: </strong>People with extreme longevity represent a unique model to study the biology of aging and discover clues to improve the general population's health. Current scoping reviews systematically map and synthesize the existing literature on supercentenarians and semisuper centenarians to identify key themes, methodologies, and findings that can inform the development of a comprehensive framework for a Global Supercentenarian Cohort Study protocol.</p><p><strong>Methods: </strong>A scoping review was conducted as per PRISMA-ScR guidelines using the PEO framework (population: semisupercentenarians aged 105+; exposure: genetics, socioecological, and other factors; outcome: supercentenarians aged 110+). Seven databases, Scopus, ProQuest, PubMed, PsycINFO, Scopus Secondary literature, Scopus Patents, and Cochrane Database of Systematic Reviews (CDSR), were searched, incorporating data from Scopus Secondary literature. Unpublished data were excluded. The scoping review protocol was published to ensure transparency and rigor.</p><p><strong>Results and discussion: </strong>144 were included. A thematic analysis of individual studies' findings was conducted to identify multidimensional themes of supercentenarian health. The following themes were identified: Age validation theme, demographics theme, behavior theme, personality, traits theme, quality of life theme, well-being and life satisfaction, cognition theme, social theme, religiosity/spirituality theme, independence/self-ability theme, mental health theme, health theme, genetics theme, and ecological theme. There was variability in the methods of assessment and tools used for each theme across different studies and inconsistencies in terminology, with similar concepts such as social support, social engagement, social contact, and social isolation being referred to by different names in various studies.</p><p><strong>Conclusion: </strong>We propose a comprehensive framework comprising three components: cohort setting, measuring contributing factors, and full assessment. This framework sets the stage for a unified, supranational protocol that harmonizes survey methods across countries, integrates multidisciplinary perspectives, and adopts a longitudinal approach. It would enable larger sample sizes and more robust statistical analyses, allowing researchers to explore complex relationships and derive more accurate conclusions about supercentenarians' health, well-being, and longevity. Developing this unified protocol necessitates the consensus of global experts.</p>","PeriodicalId":14933,"journal":{"name":"Journal of Aging Research","volume":"2026 ","pages":"1605361"},"PeriodicalIF":2.0,"publicationDate":"2026-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13090574/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147722971","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Perceptions of Aging in the Hispanic Community Members in South Central United States: A Descriptive and Exploratory Analysis.","authors":"Ethan Bradford, Basilia Oseguera, Mackenzie Reed, Shakshi Sharma, Lou Ann Eads, Jeanne Wei, Gohar Azhar","doi":"10.1155/jare/4792626","DOIUrl":"10.1155/jare/4792626","url":null,"abstract":"<p><p>The aim of this study is to investigate perceptions of aging among Hispanic adults. Fifty participants in Texas and Arkansas were asked to take a short questionnaire including multiple-choice and Likert scale format questions. Individuals 18 and older who identified as Hispanic were included in the study. Counts and frequencies for each response were obtained. Furthermore, an exploratory comparison of responses between younger and middle-aged/older respondents was conducted. According to the results of the study, the Hispanic adults surveyed were found to have a generally positive view of aging, most frequently associating older age with the words \"Wisdom\" (68%) and \"Experience\" (12%). However, respondents still had anxieties about aging, with many answering that they feared death (41.3%), loss of independence (41.7%), and financial issues (31.3%) often or always. Additionally, the majority of those surveyed indicated that they would prefer to live with their spouse only in old age, which may reflect a generational difference in attitudes toward living arrangements. Keeping these results in mind will be essential for healthcare providers as they aim to develop culturally competent educational programs to relieve caregiver burden and support healthy aging for the rapidly growing older Hispanic population in the United States.</p>","PeriodicalId":14933,"journal":{"name":"Journal of Aging Research","volume":"2026 ","pages":"4792626"},"PeriodicalIF":2.0,"publicationDate":"2026-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13085900/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147722489","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Associations Between the Gut Microbiota and Physical Activity, Sedentary Behaviour and Physical Function in Community-Dwelling Older Adults.","authors":"Catarina Ramos, Kirsty Hunter, Gemma E Walton, Anya Whitham, Nicola Camp, Carlos Poveda, Glenn R Gibson, John Hough, Daniele Magistro","doi":"10.1155/jare/8981398","DOIUrl":"10.1155/jare/8981398","url":null,"abstract":"<p><p>Gut microbiota (GM) plays a crucial role in maintaining health through metabolic, endocrine and immune functions. With ageing, shifts in GM composition, characterised by increased pathogenic and decreased health-promoting bacteria, contribute to dysbiosis, which is linked to several age-related diseases. Given the global trend of increasing sedentary behaviour (SB) and declining physical activity (PA) among older adults, this study aims to explore the relationships between GM and two critical indicators of healthy ageing, movement behaviours and physical function. Cross-sectional study assesses the GM composition, PA levels and physical function of 101 healthy, community-dwelling older adults aged 65-85 years. Participants undertook anthropometric measures and functional tests, wore an accelerometer for 7 days and provided a faecal sample which was analysed using 16s rRNA sequencing. All the results were adjusted for key covariates such as diet, age and activity levels. Key findings include positive associations of <i>Prevotella copri</i> with moderate-to-vigorous PA, physical function and negative associations with SB, while <i>Roseburia</i> species were linked to better mobility and strength measures. Conversely, potentially pathogenic taxa like <i>Bilophila wadsworthia</i> and <i>Eggerthella</i> were negatively associated with PA and handgrip strength, underscoring their possible detrimental roles in muscle function and healthy ageing. This cross-sectional study highlights the associations between GM, PA, physical function and healthy ageing in older adults. These findings emphasise the potential for leveraging GM and PA interactions to develop nonpharmacological strategies for promoting healthy ageing, warranting further research through interventional and longitudinal studies.</p>","PeriodicalId":14933,"journal":{"name":"Journal of Aging Research","volume":"2026 ","pages":"8981398"},"PeriodicalIF":2.0,"publicationDate":"2026-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13069175/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147673629","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association Between Neck Circumference, Cardiovascular Risk Factors, and Relative Muscle Strength in Older Women.","authors":"Odilon Abrahin, Naicha Stefanie Félix Souza, Simone Vitória Pantoja Sidônio, Rejane Pequeno Rodrigues Abrahin","doi":"10.1155/jare/2875747","DOIUrl":"10.1155/jare/2875747","url":null,"abstract":"<p><strong>Background: </strong>Neck circumference (NC) has been proposed as a potential anthropometric marker of cardiovascular risk, but its relationship with functional capacity in older women remains unclear.</p><p><strong>Objective: </strong>To analyze the association between NC, cardiovascular indicators, and functional capacity in older women.</p><p><strong>Methods: </strong>A cross-sectional observational study was conducted with 64 postmenopausal women aged over 60 years. Participants were stratified into two groups according to NC values < 33.5 cm (<i>n</i> = 33) and ≥ 33.5 cm (<i>n</i> = 31). Anthropometric, biochemical, and blood pressure assessments were conducted, alongside physical and functional capacity tests, including sit to stand, biceps curl, timed up and go (TUG), six-minute walk test (6MWT), and relative muscle strength. Comparisons and correlations were analyzed using appropriate statistical tests (<i>p</i> ≤ 0.05).</p><p><strong>Results: </strong>Older women with NC ≥ 33.5 cm presented higher body mass, body mass index, waist circumference, sum of skinfolds, and diastolic blood pressure. Relative muscle strength was lower in this group, with effect sizes suggesting a meaningful difference. No consistent differences were observed between groups in sit to stand, biceps curl, TUG, and 6MWT performance. NC was positively associated with cardiovascular risk markers and inversely associated with relative muscle strength, indicating a consistent pattern of association.</p><p><strong>Conclusion: </strong>Older women with higher NC values showed greater cardiovascular risk and lower relative muscle strength, but no difference in functional test performance (sit to stand, biceps curl, TUG, and 6MWT performance). These findings support NC as a practical and low-cost anthropometric indicator of cardiovascular risk in older women.</p>","PeriodicalId":14933,"journal":{"name":"Journal of Aging Research","volume":"2026 ","pages":"2875747"},"PeriodicalIF":2.0,"publicationDate":"2026-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13069176/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147673583","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Validation and Evaluation of the Chinese Version of the Healthy Aging Questionnaire in Hong Kong.","authors":"Jed Montayre, Wenjing Ning, Ka Man Carman Leung, Chun Hei Glen Cheng, Fen Liu, Juliet Chigozie Donatus Ezulike, Kay Kuo","doi":"10.1155/jare/3632426","DOIUrl":"10.1155/jare/3632426","url":null,"abstract":"<p><strong>Background: </strong>Healthy aging is a key public health priority in Hong Kong. The Healthy Aging Questionnaire, originally developed and validated in Singapore for older adults, is a concise tool for assessing multiple dimensions of healthy aging.</p><p><strong>Objectives: </strong>This study examines the psychometric performance of the Chinese version of the HAQ in the Hong Kong adult population, assessing validity, reliability, and factor structure.</p><p><strong>Research designs and methods: </strong>A cross-sectional study was conducted from October to December 2024 using convenience sampling to recruit participants aged 18 and above from various communities in Hong Kong through online and offline methods. Exploratory factor analysis and confirmatory factor analysis were performed to determine the factor structure. Cronbach's alpha, split-half reliability, and intraclass correlation coefficient were used to assess reliability.</p><p><strong>Results: </strong>The Chinese version of the HAQ demonstrated face validity and content validity. An exploratory factor analysis confirmed a three-factor structure, comprising physical/mental and sense of purpose, engagement in functional activities, and engagement in social and physical activities, with a cumulative variance contribution of 58.178%. The instrument showed Cronbach's alpha was 0.827, split-half reliability was 0.697, and an intraclass correlation coefficient was 0.630. Confirmatory factor analysis validated the three-factor structure.</p><p><strong>Discussion: </strong>The Chinese version of the HAQ is a valid and reliable tool for assessing healthy aging in the Hong Kong adult population.</p><p><strong>Implications: </strong>The robust psychometric properties support its use in research and practice to evaluate and promote healthy aging. Future studies should validate the HAQ in longitudinal research.</p>","PeriodicalId":14933,"journal":{"name":"Journal of Aging Research","volume":"2026 ","pages":"3632426"},"PeriodicalIF":2.0,"publicationDate":"2026-04-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13058564/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147645293","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Types of Adversity, Perceived Stressfulness and Resilience in Older Men and Women.","authors":"Sini M Stenroth, Markus J Haapanen, Sini Siltanen, Pirjo Vuoskoski, Johan G Eriksson, Mikaela B von Bonsdorff","doi":"10.1155/jare/1018774","DOIUrl":"10.1155/jare/1018774","url":null,"abstract":"<p><p>We investigated stressful adversities older adults face, examined whether older men and women experience them differently, assessed the stressfulness of these events and studied their relationship to resilience-the ability to overcome adversity. This cross-sectional study included 1179 respondents from the Helsinki Birth Cohort Study, born between 1934 and 1944. At a mean age of 75 years, respondents reported the most stressful adversity in the past five years, its perceived stressfulness and resilience using the Hardy-Gill resilience scale. Adversities were coded using a qualitative content analysis. General linear modelling was used to examine the relationship between perceived stressfulness and resilience across types of adversity. We identified ten types of highly stressful adversities, with the five most common being personal illness (23.6%), illness (17.6%) or death (15.8%) of a close relative, relationship adversity (12.7%) and adversity related to living situations (8.6%). 4.8% of participants experienced ageing-related changes as the most stressful adversities. Reported adversities were generally perceived as highly stressful, while resilience scores were intermediate. Men reported more self-related adversity, perceived these as less stressful and showed better coping (a higher mean resilience scale score) than women after a highly stressful adversity. The identified highly stressful adversities included two previously unreported types related to the ageing process: 'having to give up…' (e.g., driving) and 'health/functional decline'. Although the reported adversities were highly stressful, respondents coped well, suggesting a good capacity to manage adversity in later life.</p>","PeriodicalId":14933,"journal":{"name":"Journal of Aging Research","volume":"2026 ","pages":"1018774"},"PeriodicalIF":2.0,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13045286/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147623103","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence and Risk Factors of Pain Among Older People in Mexico: Evidence From MHAS 2018.","authors":"Tianwei Zhang, Qumin Chen, Xiaodong Li, Baoshan Hu","doi":"10.1155/jare/5547878","DOIUrl":"10.1155/jare/5547878","url":null,"abstract":"<p><strong>Objective: </strong>To explore the prevalence of pain and its risk factors among older people in Mexico.</p><p><strong>Methods: </strong>We conducted a cross-sectional analysis using data from the 2018 Mexican Health and Aging Study (MHAS), which included 8958 participants aged 60 years and above. Variables including pain, social demographics, and health-related factors were collected through questionnaire surveys, and a binary logistic regression model was used to identify risk factors associated with pain.</p><p><strong>Results: </strong>The prevalence of pain among older people in Mexico was 40.8%. Multivariate regression analysis showed that female gender, obesity, retirement, incapacity or inability to work, hypertension, diabetes, arthritis/rheumatism, heart attack, and cancer history were positively correlated with pain. In contrast, higher levels of education, widowhood, household chores, and exercising more than three times a week are negatively correlated with pain. However, age, smoking, and alcohol consumption did not show any significant correlation to pain.</p><p><strong>Conclusion: </strong>The prevalence of pain is relatively high among older people in Mexico. Targeted intervention measures should be taken to improve awareness of the risk factors and the prevention of pain.</p>","PeriodicalId":14933,"journal":{"name":"Journal of Aging Research","volume":"2026 ","pages":"5547878"},"PeriodicalIF":2.0,"publicationDate":"2026-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13618134/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149074937","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Scoping Review on the Impact of the Environment on Racialized Immigrant Older Adults' Social Connectedness and Sense of Belonging.","authors":"Vivian Afrah Puplampu, Ashley Hai Yen Ho, Mashrur Kazi, Alberta Baffour-Awuah, Michelle Dalidowicz, Juliet Bushi, Jordana Salma, Joseph Osuji, Festus Y Moasun, Mary Chipanshi, Florence Luhanga, Anahit Falihi, Christina Nsaliwa, Jordan Pierson, Leonie Mvumbi Mambu, Bukola Salami","doi":"10.1155/jare/1089194","DOIUrl":"10.1155/jare/1089194","url":null,"abstract":"<p><strong>Background and objective: </strong>The increasing number of immigrant and older adult populations in Canada is reflected among racialized groups. Migrating to a new country at an older age, language barriers, financial concerns and immigration policies present challenges for connecting to the community. Many racialized immigrant older adults (RIOAs) experience challenges related to engaging in and feeling a sense of belonging in the community. This scoping review maps out and summarizes evidence on the impact of the environment on RIOAs' social connections and belongingness in Canada.</p><p><strong>Methods: </strong>Ageline, CINAHL, Medline (Ovid), APA PsycInfo, Sociological Abstracts, Joanna Briggs Institute EBP Database, the Cochrane Database and ProQuest Dissertation & Theses Global were searched for peer-reviewed articles. Articles were included if they were published in English within the last 12 years, focused on RIOAs (non-White and non-Indigenous individuals aged 55 years and above) and reported on their connectedness and/or sense of belonging in Canada. Qualitative content analysis was used to code the data, the interpretation of which was guided by the social ecological model.</p><p><strong>Results: </strong>Thirty-seven articles met the inclusion criteria, and five interrelated categories were identified: (1) Intrapersonal Level: RIOAs' characteristics, expectations and choice of living arrangement; (2) Interpersonal Level: Meaning of social connection and experience of support; (3) Organizational Level: RIOAs' experience with institutions in Canada; (4) Community Level: RIOAs' experience in their neighbourhood; and (5) Public Policy Level: Poverty and retirement in Canada.</p><p><strong>Conclusion: </strong>Interconnected factors that affect RIOAs' social connectedness and sense of belonging in Canada include personal characteristics, family status, the neighbourhood in which they reside and policy implications. Considering the aforementioned factors in programme and policy development may inform how to better support this population in Canada.</p><p><strong>Implications: </strong>A collaborative effort from family members, neighbours, community members, organizations and policymakers is needed to facilitate RIOAs' engagement and sense of belonging in the community.</p>","PeriodicalId":14933,"journal":{"name":"Journal of Aging Research","volume":"2026 ","pages":"1089194"},"PeriodicalIF":2.0,"publicationDate":"2026-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12921639/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147271121","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Relationship Between Weight, Muscle Mass, Cardiorespiratory Endurance, and Likelihood of Dynapenia in Older Adults.","authors":"Mei Chu Chen, Der-Sheng Han, Ke-Vin Chang, Shang-Jyh Chiou","doi":"10.1155/jare/5537797","DOIUrl":"10.1155/jare/5537797","url":null,"abstract":"<p><strong>Background: </strong>In an aging society, the early detection and diagnosis of dynapenia, defined as the <i>age-associated loss of muscle strength,</i> are pivotal for preventing or decreasing the deterioration of body functions. This study aims to explore the relationship between dynapenia and nutrition, body fitness, and physical activity.</p><p><strong>Methods: </strong>This cross-sectional study surveyed participants at a regional hospital in 2017. The survey utilized the Mini Nutritional Assessment and the International Physical Activity Questionnaire. The body weight, height, appendicular skeletal <i>muscle</i>-mass index (ASMI), calf circumference, balance, lower limb flexibility, muscular endurance, and cardiorespiratory endurance of the participants were measured by trained staff. Additionally, logistic regression models were used to explore the risk factors for dynapenia.</p><p><strong>Results: </strong>Among the 393 cases, overweight status, obesity, and below-normal calf circumference were associated with an increased likelihood of dynapenia, with odds ratios (ORs) of 2.15 (<i>p</i> = 0.019), 4.15 (<i>p</i> = 0.002), and 2.15 (<i>p</i> = 0.02), respectively. Conversely, higher ASMI and cardiorespiratory endurance were associated with a decreased likelihood of dynapenia, with ORs of 0.41 (<i>p</i> = 0.002) and 0.97 (<i>p</i> = 0.001), respectively. Additionally, old age increased the likelihood of dynapenia with an OR of 1.18 (<i>p</i> < 0.001). Other variables were not significant.</p><p><strong>Conclusions: </strong>Controlling body weight and encouraging older adults to engage in physical activities that enhance handgrip strength can reduce the risk of dynapenia. Therefore, promoting self-care behaviors to reduce the adverse outcomes of dynapenia is crucial for enhancing healthy life in older populations.</p>","PeriodicalId":14933,"journal":{"name":"Journal of Aging Research","volume":"2026 ","pages":"5537797"},"PeriodicalIF":2.0,"publicationDate":"2026-02-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12914332/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146226813","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of Sperm DNA Fragmentation on Embryonic Cleavage and Semen Parameters in In Vitro Fertilization Treatment.","authors":"Yu-Li Chuang, Hsiao-Chin Huang, Cheng-Hsuan Wu, Shiao-Hsuan Yang, Yu-Ching Chen, Horng-Der Tsai, Hsin-Hung Wu","doi":"10.1155/jare/9920736","DOIUrl":"10.1155/jare/9920736","url":null,"abstract":"<p><strong>Objective: </strong>Sperm DNA fragmentation (SDF) may influence embryonic development during in vitro fertilization (IVF) treatment. This study examined the relationship between SDF and embryonic development and correlations between SDF and semen parameters.</p><p><strong>Materials and methods: </strong>This retrospective study included couples who received IVF treatment at the Reproductive Medicine Center of Changhua Christian Hospital between July 2020 and May 2022. Couples who experienced repeated implantation failure were suggested to an SDF test, and their most recent IVF treatment results were examined. IVF treatment data were collected for 52 couples. SDF was evaluated using a terminal deoxynucleotidyl transferase-mediated deoxyuridine triphosphate nick end labeling (TUNEL) assay, calculated as 100 × (number of spermatozoa with fragmented DNA/total number of spermatozoa). Couples were divided into two groups on the basis of their SDF ratio: Group 1 (SDF < 20%) and Group 2 (SDF ≥ 20%). The numbers of embryos at the two-pronuclear, cleavage, and blastocyst stages were analyzed using a Chi-square test. Semen parameters were analyzed using a <i>t</i> test.</p><p><strong>Results: </strong>In all IVF treatment cycles, the fertilization rate was significantly lower in Group 2 than in Group 1 (78.62% vs. 68.88%, <i>p</i> = 0.0378). The cleavage rate was also significantly lower in Group 2 than in Group 1 (57.89% vs. 37.35%, <i>p</i> = 0.0007). The clinical outcome also revealed significantly increased miscarriage rate in Group 2 than in Group 1 (6.25% vs. 14.29%, <i>p</i> ≤ 0.005). Subgroup analysis of young mothers revealed lower fertilization and cleavage rates in Group 2, although the differences were not significant. Analysis of semen parameters revealed significantly lower semen concentrations, sperm motility, and progressive motility in Group 2.</p><p><strong>Conclusion: </strong>SDF affects early embryonic development. A high SDF ratio is significantly associated with low fertilization and cleavage rates and lower semen concentrations, sperm motility, and progressive motility. The embryo derived from higher SDF ratio sperm also has significantly higher miscarriage rate after embryo transfer. In conclusion, SDF analysis can be used as a useful examination for male fertility before assisted reproductive therapy, especially couples with history of repeat IVF treatment.</p>","PeriodicalId":14933,"journal":{"name":"Journal of Aging Research","volume":"2026 ","pages":"9920736"},"PeriodicalIF":2.0,"publicationDate":"2026-02-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12891805/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146179996","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}