Journal of Animal Science and Biotechnology最新文献

{"title":"Whole-genome resequencing to investigate the genetic diversity and mechanisms of plateau adaptation in Tibetan sheep","authors":"Xue Li, Buying Han, Dehui Liu, Song Wang, Lei Wang, Quanbang Pei, Zian Zhang, Jincai Zhao, Bin Huang, Fuqiang Zhang, Kai Zhao, Dehong Tian","doi":"10.1186/s40104-024-01125-1","DOIUrl":"https://doi.org/10.1186/s40104-024-01125-1","url":null,"abstract":"Tibetan sheep, economically important animals on the Qinghai–Tibet Plateau, have diversified into numerous local breeds with unique characteristics through prolonged environmental adaptation and selective breeding. However, most current research focuses on one or two breeds, and lacks a comprehensive representation of the genetic diversity across multiple Tibetan sheep breeds. This study aims to fill this gap by investigating the genetic structure, diversity and high-altitude adaptation of 6 Tibetan sheep breeds using whole-genome resequencing data. Six Tibetan sheep breeds were investigated in this study, and whole-genome resequencing data were used to investigate their genetic structure and population diversity. The results showed that the 6 Tibetan sheep breeds exhibited distinct separation in the phylogenetic tree; however, the levels of differentiation among the breeds were minimal, with extensive gene flow observed. Population structure analysis broadly categorized the 6 breeds into 3 distinct ecological types: plateau-type, valley-type and Euler-type. Analysis of unique single-nucleotide polymorphisms (SNPs) and selective sweeps between Argali and Tibetan sheep revealed that Tibetan sheep domestication was associated primarily with sensory and signal transduction, nutrient absorption and metabolism, and growth and reproductive characteristics. Finally, comprehensive analysis of selective sweep and transcriptome data suggested that Tibetan sheep breeds inhabiting different altitudes on the Qinghai–Tibet Plateau adapt by enhancing cardiopulmonary function, regulating body fluid balance through renal reabsorption, and modifying nutrient digestion and absorption pathways. In this study, we investigated the genetic diversity and population structure of 6 Tibetan sheep breeds in Qinghai Province, China. Additionally, we analyzed the domestication traits and investigated the unique adaptation mechanisms residing varying altitudes in the plateau region of Tibetan sheep. This study provides valuable insights into the evolutionary processes of Tibetan sheep in extreme environments. These findings will also contribute to the preservation of genetic diversity and offer a foundation for Tibetan sheep diversity preservation and plateau animal environmental adaptation mechanisms.","PeriodicalId":14928,"journal":{"name":"Journal of Animal Science and Biotechnology","volume":"31 1","pages":""},"PeriodicalIF":7.0,"publicationDate":"2024-12-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142782736","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of maternal feeding of clofibrate on hepatic fatty acid metabolism in suckling piglet","authors":"Jinan Zhao, Brandon Pike, Feng Wang, Lin Yang, Paige Meisner, Yanling Huang, Jack Odle, Xi Lin","doi":"10.1186/s40104-024-01104-6","DOIUrl":"https://doi.org/10.1186/s40104-024-01104-6","url":null,"abstract":"Energy deficiency is a leading cause of the high pre-weaning mortality of neonatal piglets in the swine industry. Thus, optimal energy metabolism is of crucial importance for improving the survivability of neonatal piglets. The effective utilization of milk fat as primary energy is indispensably required. Pregnant sows (n = 27) were randomly assigned into 3 treatments. Each treatment received a standard diet (3,265 kcal ME/kg) supplemented with either 0, 0.25% or 0.5% clofibrate (w/w) from d 107 of gestation to d 7 of lactation. The effects of maternal clofibrate on their milk fatty acid (FA) and performance of the piglets were evaluated. The evaluations were performed via measuring sow productive performance, milk FA composition, and hepatic FA oxidation of the piglets at birth and d 1, 7, 14 and 19 after birth. Maternal supplementation of clofibrate had no effect on reproductive performance of the sows at farrowing and weaning (P > 0.05). However, the mortality at weaning was reduced for piglets from sows with 0.25% of clofibrate, and the average weekly (and daily) gain was higher in piglets from sows that received clofibrate than sows without clofibrate in the first week (P < 0.0001). Maternal clofibrate increased percentage of milk C12:0 and C14:0 FAs but decreased C18:2 and n-6 polyunsaturated FAs. Maternal clofibrate also increased plasma ketone body levels and hepatic FA oxidation measured at the first day of birth, but the increase was not detected in piglets on d 7, 14 or 19. Clofibrate was not detected in milk collected from the clofibrate-treated sows. The percentage of FA oxidation decreased, and the percentage of FA esterification increased with increasing in postnatal age. Supplemental carnitine increased FA oxidation regardless of succinate dehydrogenase inhibition, and the increase had no effect on FA esterification. Maternal supplementation of clofibrate during late gestation and early lactation increases hepatic FA oxidative metabolism at birth and improves growth performance of newborn piglets. Maternal clofibrate transfer to suckling piglets via milk was not detected. Carnitine availability is critical for piglets to maintain a high FA oxidation rate during the suckling period.","PeriodicalId":14928,"journal":{"name":"Journal of Animal Science and Biotechnology","volume":"87 1","pages":""},"PeriodicalIF":7.0,"publicationDate":"2024-12-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142776387","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Construction of the porcine genome mobile element variations and investigation of its role in population diversity and gene expression","authors":"Jianchao Hu, Lu Gui, Zhongzi Wu, Lusheng Huang","doi":"10.1186/s40104-024-01121-5","DOIUrl":"https://doi.org/10.1186/s40104-024-01121-5","url":null,"abstract":"Mobile element variants (MEVs) have a significant and complex impact on genomic diversity and phenotypic traits. However, the quantity, distribution, and relationship with gene expression and complex traits of MEVs in the pig genome remain poorly understood. We constructed the most comprehensive porcine MEV library based on high-depth whole genome sequencing (WGS) data from 747 pigs across 59 breeds worldwide. This database identified a total of 147,993 polymorphic MEVs, including 121,099 short interspersed nuclear elements (SINEs), 26,053 long interspersed nuclear elements (LINEs), 802 long terminal repeats (LTRs), and 39 other transposons, among which 54% are newly discovered. We found that MEVs are unevenly distributed across the genome and are strongly influenced by negative selection effects. Importantly, we identified 514, 530, and 584 candidate MEVs associated with population differentiation, domestication, and breed formation, respectively. For example, a significantly differentiated MEV is located in the ATRX intron between Asian and European pigs, whereas ATRX is also differentially expressed between Asian and European pigs in muscle tissue. In addition, we identified 4,169 expressed MEVs (eMEVs) significantly associated with gene expression and 6,914 splicing MEVs (sMEVs) associated with gene splicing based on RNA-seq data from 266 porcine liver tissues. These eMEVs and sMEVs explain 6.24% and 9.47%, respectively, of the observed cis-heritability and highlight the important role of MEVs in the regulation of gene expression. Finally, we provide a high-quality SNP–MEV reference haplotype panel to impute MEV genotypes from genome-wide SNPs. Notably, we identified a candidate MEV significantly associated with total teat number, demonstrating the functionality of this reference panel. The present investigation demonstrated the importance of MEVs in pigs in terms of population diversity, gene expression and phenotypic traits, which may provide useful resources and theoretical support for pig genetics and breeding.","PeriodicalId":14928,"journal":{"name":"Journal of Animal Science and Biotechnology","volume":"37 1","pages":""},"PeriodicalIF":7.0,"publicationDate":"2024-12-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142763209","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Necroptosis contributes to deoxynivalenol-induced liver injury and inflammation in weaned piglets","authors":"Qilong Xu, Hanqiu Gong, Mohan Zhou, Junjie Guo, Shaokui Chen, Kan Xiao, Yulan Liu","doi":"10.1186/s40104-024-01117-1","DOIUrl":"https://doi.org/10.1186/s40104-024-01117-1","url":null,"abstract":"The aim of this study was to investigate the role of necroptosis in deoxynivalenol (DON)-induced liver injury and inflammation in weaned piglets. In Exp. 1, 12 weaned piglets were divided into 2 groups including pigs fed basal diet and pigs fed diet contaminated with 4 mg/kg DON for 21 d. In Exp. 2, 12 weaned piglets were divided into 2 groups including control piglets and piglets given a gavage of 2 mg/kg body weight (BW) DON. In Exp. 3, 24 weaned piglets were used in a 2 × 2 factorial design and the main factors including necrostatin-1 (Nec-1) (DMSO or 0.5 mg/kg BW Nec-1) and DON challenge (saline or 2 mg/kg BW DON gavage). On 21 d in Exp. 1, or at 6 h post DON gavage in Exp. 2 and 3, pigs were killed for blood samples and liver tissues. Liver histology, blood biochemical indicators, and liver inflammation and necroptosis signals were tested. Dietary or oral gavage with DON caused liver morphological damage in piglets. Dietary DON led to hepatocyte damage indicated by increased aspartate transaminase (AST) activity and AST/alanine aminotransferase (ALT) ratio, and DON gavage also caused hepatocyte damage and cholestasis indicated by increased AST and alkaline phosphatase (AKP) activities. Dietary DON caused liver necroptosis indicated by increased protein abundance of total receptor interacting protein kinase 3 (t-RIP3) and total mixed lineage kinase domain-like protein (t-MLKL). Moreover, DON gavage increased mRNA expression of interleukin (IL)-6 and IL-1β in liver. DON gavage also induced liver necroptosis demonstrated by increased protein abundance of t-RIP3, phosphorylated-RIP3 (p-RIP3), t-MLKL and p-MLKL. However, pretreatment with Nec-1, a specific inhibitor of necroptosis, inhibited liver necroptosis indicated by decreased protein expression of t-RIP3, p-RIP3, t-MLKL and p-MLKL. Nec-1 pretreatment reduced liver morphological damage after DON gavage. Pretreatment with Nec-1 also attenuated liver damage induced by DON indicated by decreased activities of AST and AKP. Furthermore, Nec-1 pretreatment inhibited liver mRNA expression of IL-6 and IL-1β after DON challenge. Our data demonstrate for the first time that necroptosis contributes to DON-induced liver injury and inflammation in piglets.","PeriodicalId":14928,"journal":{"name":"Journal of Animal Science and Biotechnology","volume":"198 1","pages":""},"PeriodicalIF":7.0,"publicationDate":"2024-12-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142759924","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Chlorogenic acid alleviates IPEC-J2 pyroptosis induced by deoxynivalenol by inhibiting activation of the NF-κB/NLRP3/caspase-1 pathway","authors":"Yanmei Xue, Fuchang Li, Rui Li, Xinru Zhang, Huijun Guo, Chunyang Wang","doi":"10.1186/s40104-024-01119-z","DOIUrl":"https://doi.org/10.1186/s40104-024-01119-z","url":null,"abstract":"Deoxynivalenol (DON) is a mycotoxin that severely pollutes feed ingredients, and methods for reducing DON toxicity have become a significant research direction. Chlorogenic acid (CGA) is an active polyphenol found in some plants, which has anti-inflammatory and antioxidant properties and a protective effect on animal intestinal health. The effects of CGA on DON-induced pyroptosis in the intestinal porcine epithelial cell line-J2 (IPEC-J2) and its potential mechanism were explored in this study. IPEC-J2 cells viability and membrane integrity were inversely correlated with DON concentration. Compared to those in the group treated with DON alone at 2,500 ng/mL, pretreatment with 80 μmol/L CGA for 4 h significantly improved cell viability (P < 0.01), and the alleviation of typical pyroptotic symptoms induced by DON were observed, including reduced cellular DNA fragmentation, decreased release of lactate dehydrogenase (LDH), normalized ROS levels, restoration of extracellular Ca2+ and K+ contents to normal levels (P < 0.01 ), as well as suppressed the enzyme activities of caspase-1 and caspase-4 (P < 0.01). Additionally, the mRNA expression levels of TNF, MDP, NOD2, TLR4, ASC and GSDMD were significantly improved (P < 0.01), while both mRNA and protein expression levels of NF-κB, NLRP3, caspase-1, IL-1β and IL-18 were significantly upregulated (P < 0.01) in the CGA + DON group, compare to those in the DON group. Pretreatment with 80 μmol/L CGA for 4 h effectively alleviated pyroptosis in IPEC-J2 cells induced by 2,500 ng/mL of DON through inhibiting activation of the NF-κB/ NLRP3/capase-1 pathway.","PeriodicalId":14928,"journal":{"name":"Journal of Animal Science and Biotechnology","volume":"3 1","pages":""},"PeriodicalIF":7.0,"publicationDate":"2024-12-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142758155","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Retraction Note: Dietary garcinol supplementation improves diarrhea and intestinal barrier function associated with its modulation of gut microbiota in weaned piglets","authors":"Tongxin Wang, Weilei Yao, Juan Li, Yafei Shao, Qiongyu He, Jun Xia, Feiruo Huang","doi":"10.1186/s40104-024-01134-0","DOIUrl":"https://doi.org/10.1186/s40104-024-01134-0","url":null,"abstract":"This article has been retracted. Please see the Retraction Notice for more detail: https://doi.org/10.1186/s40104-020-0426-6.","PeriodicalId":14928,"journal":{"name":"Journal of Animal Science and Biotechnology","volume":"75 1","pages":""},"PeriodicalIF":7.0,"publicationDate":"2024-12-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142758456","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Improvement of antioxidant capability by dietary N-acetyl cysteine supplementation alleviates bone loss induced by chronic heat stress in finisher broilers","authors":"Huaiyong Zhang, Herinda Pertiwi, Joris Michiels, Djoere Gaublomme, Maryam Majdeddin, Yuhuang Hou, Matthieu Boone, Dirk Elewaut, Iván Josipovic, Jeroen Degroote","doi":"10.1186/s40104-024-01114-4","DOIUrl":"https://doi.org/10.1186/s40104-024-01114-4","url":null,"abstract":"Heat stress (HS) incidence is associated with the accumulation of reactive substances, which might be associated with bone loss. N-Acetylcysteine (NAC) exhibits strong antioxidants due to its sulfhydryl group and being as the precursor for endogenous glutathione synthesis. Therefore, interplay between oxidative stress and bone turnover of broilers and the effects of dietary NAC inclusion on antioxidant capability and “gut-bone” axis were evaluated during chronic HS. Implementing cyclic chronic HS (34 °C for 7 h/d) evoked reactive oxygen species excessive production and oxidant stress, which was accompanied by compromised tibia mass. The RNA-seq of proximal tibia also revealed the enrichment of oxidation–reduction process and inflammatory outbursts during HS. Although no notable alterations in the growth performance and cecal microbiota were found, the diet contained 2 g/kg NAC enhanced the antioxidant capability of heat-stressed broiler chickens by upregulating the expression of Nrf2 in the ileum, tibia, and bone marrow. Simultaneously, NAC tended to hinder NF-κB pathway activation and decreased the mRNA levels of the proinflammatory cytokines in both the ileum and bone marrow. As a result, NAC suppressed osteoclastogenesis and osteoclast activity, thereby increasing osteocyte-related gene expression. Furthermore, the inclusion of NAC tended to increase the ash content and density of the whole tibia, as well as improve cortical thickness and bone volume of the diaphysis. These findings HS-mediated outburst of oxidant stress accelerates bone resorption and negatively regulates the bone quality of tibia, which is inhibited by NAC in broilers. ","PeriodicalId":14928,"journal":{"name":"Journal of Animal Science and Biotechnology","volume":"203 1","pages":""},"PeriodicalIF":7.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142756380","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction: Embryotrophic effect of exogenous protein contained adipose-derived stem cell extracellular vesicles","authors":"Seonggyu Bang, Ahmad Yar Qamar, Sung Ho Yun, Na‑Yeon Gu, Heyyoung Kim, Ayeong Han, Heejae Kang, Hye Sun Park, Seung II Kim, Islam M. Saadeldin, Sanghoon Lee, Jongki Cho","doi":"10.1186/s40104-024-01127-z","DOIUrl":"https://doi.org/10.1186/s40104-024-01127-z","url":null,"abstract":"&lt;p&gt;&lt;b&gt;Correction&lt;/b&gt;&lt;b&gt;: &lt;/b&gt;&lt;b&gt;J Animal Sci Biotechnol 15, 145 (2024)&lt;/b&gt;&lt;/p&gt;&lt;p&gt;&lt;b&gt;https://doi.org/10.1186/s40104-024-01106-4&lt;/b&gt;&lt;/p&gt;&lt;br/&gt;&lt;p&gt;Following publication of the original article [1], the authors reported an error in authors’ affiliations due to typesetting error, where the 3&lt;sup&gt;rd&lt;/sup&gt; and 4&lt;sup&gt;th&lt;/sup&gt; institutions are the same. Also, a full stop was erroneously added to author Seung II Kim’s name.&lt;/p&gt;&lt;p&gt;The full list of authors and affiliations is changed from:&lt;/p&gt;&lt;p&gt;Seonggyu Bang&lt;sup&gt;1,2&lt;/sup&gt;, Ahmad Yar Qamar&lt;sup&gt;3&lt;/sup&gt;, Sung Ho Yun&lt;sup&gt;5&lt;/sup&gt;, Na-Yeon Gu&lt;sup&gt;6&lt;/sup&gt;, Heyyoung Kim&lt;sup&gt;2,7&lt;/sup&gt;, Ayeong Han&lt;sup&gt;1,2&lt;/sup&gt;, Heejae Kang&lt;sup&gt;1,2&lt;/sup&gt;, Hye Sun Park&lt;sup&gt;4&lt;/sup&gt;, Seung II. Kim&lt;sup&gt;4&lt;/sup&gt;, Islam M. Saadeldin&lt;sup&gt;2,8&lt;/sup&gt;, Sanghoon Lee&lt;sup&gt;2&lt;/sup&gt; and Jongki Cho&lt;sup&gt;1&lt;/sup&gt;&lt;sup&gt;*&lt;/sup&gt;&lt;/p&gt;&lt;p&gt;1 College of Veterinary Medicine and Research Institute for Veterinary Science, Seoul National University, Seoul 08826, Republic of Korea.&lt;/p&gt;&lt;p&gt;2 College of Veterinary Medicine, Chungnam National University, Daejeon 34134, Republic of Korea.&lt;/p&gt;&lt;p&gt;3 College of Veterinary and Animal Sciences, Jhang Sub-campus of University of Veterinary and Animal Sciences, Lahore, Pakistan.&lt;/p&gt;&lt;p&gt;4 College of Veterinary and Animal Sciences, Jhang, Sub-Campus of University of Veterinary and Animal Sciences, Lahore 54000, Pakistan.&lt;/p&gt;&lt;p&gt;5 Korea Basic Science Institute (KBSI), Ochang, Chungcheongbuk‑Do 28119, Republic of Korea.&lt;/p&gt;&lt;p&gt;6 Viral Disease Research Division, Animal and Plant Quarantine Agency, Gimcheon, Gyeongsangbuk‑Do 39660, Republic of Korea.&lt;/p&gt;&lt;p&gt;7 Department of Plastic and Reconstructive Surgery, Vascularized Composite Allotransplantation (VCA)&lt;/p&gt;&lt;p&gt;Laboratory, Johns Hopkins School of Medicine, Baltimore, MD 21205, USA.&lt;/p&gt;&lt;p&gt;8 Comparative Medicine Department, King Faisal Specialist Hospital &amp; Research Centre, Riyadh 11211, Saudi Arabia.&lt;/p&gt;&lt;p&gt;To:&lt;/p&gt;&lt;p&gt;Seonggyu Bang&lt;sup&gt;1,2&lt;/sup&gt;, Ahmad Yar Qamar&lt;sup&gt;3&lt;/sup&gt;, Sung Ho Yun&lt;sup&gt;4&lt;/sup&gt;, Na‑Yeon Gu&lt;sup&gt;5&lt;/sup&gt;, Heyyoung Kim&lt;sup&gt;2,6&lt;/sup&gt;, Ayeong Han&lt;sup&gt;1,2&lt;/sup&gt;, Heejae Kang&lt;sup&gt;1,2&lt;/sup&gt;, Hye Sun Park&lt;sup&gt;4&lt;/sup&gt;, Seung II Kim&lt;sup&gt;4&lt;/sup&gt;, Islam M. Saadeldin&lt;sup&gt;2,7&lt;/sup&gt;, Sanghoon Lee&lt;sup&gt;2&lt;/sup&gt; and Jongki Cho&lt;sup&gt;1&lt;/sup&gt;&lt;sup&gt;*&lt;/sup&gt;&lt;/p&gt;&lt;p&gt;1 College of Veterinary Medicine and Research Institute for Veterinary Science, Seoul National University, Seoul 08826, Republic of Korea.&lt;/p&gt;&lt;p&gt;2 College of Veterinary Medicine, Chungnam National University, Daejeon 34134, Republic of Korea.&lt;/p&gt;&lt;p&gt;3 College of Veterinary and Animal Sciences, Jhang Sub-campus of University of Veterinary and Animal Sciences, Lahore 54000, Pakistan.&lt;/p&gt;&lt;p&gt;4 Korea Basic Science Institute (KBSI), Ochang, Chungcheongbuk‑Do 28119, Republic of Korea.&lt;/p&gt;&lt;p&gt;5 Viral Disease Research Division, Animal and Plant Quarantine Agency, Gimcheon, Gyeongsangbuk‑Do 39660, Republic of Korea.&lt;/p&gt;&lt;p&gt;6 Department of Plastic and Reconstructive Surgery, Vascularized Composite Allotransplantation (VCA)&lt;/p&gt;&lt;p&gt;Laboratory, Johns Hopkins ","PeriodicalId":14928,"journal":{"name":"Journal of Animal Science and Biotechnology","volume":"2675 1","pages":""},"PeriodicalIF":7.0,"publicationDate":"2024-11-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142753705","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction: Dietary supplementation with pterostilbene activates the PI3K-AKT-mTOR signalling pathway to alleviate progressive oxidative stress and promote placental nutrient transport","authors":"Mingming Cao, Liyun Bai, Haoyun Wei, Yantong Guo, Guodong Sun, Haoyang Sun, Baoming Shi","doi":"10.1186/s40104-024-01124-2","DOIUrl":"https://doi.org/10.1186/s40104-024-01124-2","url":null,"abstract":"&lt;p&gt;&lt;b&gt;Correction&lt;/b&gt;&lt;b&gt;: &lt;/b&gt;&lt;b&gt;J Animal Sci Biotechnol 15, 133 (2024)&lt;/b&gt;&lt;/p&gt;&lt;p&gt;&lt;b&gt;https://doi.org/10.1186/s40104-024-01090-9&lt;/b&gt;&lt;/p&gt;&lt;br/&gt;&lt;p&gt;Following publication of the original article [1], the authors reported errors in the legend of Fig. 7 and the &lt;i&gt;P&lt;/i&gt; value of Fig. 8G (0.66 should be corrected to 0.066).\u0000&lt;/p&gt;&lt;p&gt;The originally published legend of Fig. 7 was:&lt;/p&gt;&lt;p&gt;Effect of PTE on milk composition, antioxidant capacity, inflammatory factors and immunoglobulins. &lt;b&gt;A&lt;/b&gt; Colostrum composition. &lt;b&gt;B&lt;/b&gt; Colostrum antioxidant capacity. &lt;b&gt;C&lt;/b&gt; Colostrum inflammatory factor levels. &lt;b&gt;D&lt;/b&gt; Colostrum immunoglobulin levels. &lt;b&gt;E&lt;/b&gt; Milk composition. &lt;b&gt;F&lt;/b&gt; Milk antioxidant capacity. &lt;b&gt;G&lt;/b&gt; Milk inflammatory factor levels. &lt;b&gt;H&lt;/b&gt; Milk immunoglobulin levels. CON: control group; PTE: Pterostilbene group. Data are expressed as mean ± SD (&lt;i&gt;n&lt;/i&gt; = 6 for each group). &lt;sup&gt;*&lt;/sup&gt;&lt;i&gt;P&lt;/i&gt; &lt; 0.05, compared to the control group.&lt;/p&gt;&lt;p&gt;The corrected legend of Fig. 7 should read:&lt;/p&gt;&lt;p&gt;Effect of PTE on milk composition, antioxidant capacity, inflammatory factors and immunoglobulins. &lt;b&gt;A&lt;/b&gt; Colostrum composition. &lt;b&gt;B&lt;/b&gt; Colostrum antioxidant capacity. &lt;b&gt;C&lt;/b&gt; Colostrum inflammatory factor levels and colostrum immunoglobulin levels. &lt;b&gt;D&lt;/b&gt; Milk composition. &lt;b&gt;E&lt;/b&gt; Milk antioxidant capacity. &lt;b&gt;F&lt;/b&gt; Milk inflammatory factor levels and milk immunoglobulin levels. CON: Control group; PTE: Pterostilbene group. Data are expressed as mean ± SD (&lt;i&gt;n&lt;/i&gt; = 6 for each group). &lt;sup&gt;*&lt;/sup&gt;&lt;i&gt;P&lt;/i&gt; &lt; 0.05, compared to the control group.&lt;/p&gt;&lt;p&gt;The originally published Fig. 8 was:&lt;/p&gt;&lt;figure&gt;&lt;figcaption&gt;&lt;b data-test=\"figure-caption-text\"&gt;Fig. 8&lt;/b&gt;&lt;/figcaption&gt;&lt;picture&gt;&lt;source srcset=\"//media.springernature.com/lw685/springer-static/image/art%3A10.1186%2Fs40104-024-01124-2/MediaObjects/40104_2024_1124_Fig1_HTML.png?as=webp\" type=\"image/webp\"/&gt;&lt;img alt=\"figure 1\" aria-describedby=\"Fig1\" height=\"431\" loading=\"lazy\" src=\"//media.springernature.com/lw685/springer-static/image/art%3A10.1186%2Fs40104-024-01124-2/MediaObjects/40104_2024_1124_Fig1_HTML.png\" width=\"685\"/&gt;&lt;/picture&gt;&lt;p&gt;Effect of PTE on fecal SCFAs in sows (&lt;b&gt;A&lt;/b&gt;–&lt;b&gt;G&lt;/b&gt;). CON: control group; PTE: Pterostilbene group. Data are expressed as mean ± SD (&lt;i&gt;n&lt;/i&gt; = 6 for each group). &lt;sup&gt;*&lt;/sup&gt;&lt;i&gt;P&lt;/i&gt; &lt; 0.05, compared to the control group&lt;/p&gt;&lt;span&gt;Full size image&lt;/span&gt;&lt;svg aria-hidden=\"true\" focusable=\"false\" height=\"16\" role=\"img\" width=\"16\"&gt;&lt;use xlink:href=\"#icon-eds-i-chevron-right-small\" xmlns:xlink=\"http://www.w3.org/1999/xlink\"&gt;&lt;/use&gt;&lt;/svg&gt;&lt;/figure&gt;&lt;p&gt;The corrected Fig. 8 should read:&lt;/p&gt;&lt;figure&gt;&lt;figcaption&gt;&lt;b data-test=\"figure-caption-text\"&gt;Fig. 8&lt;/b&gt;&lt;/figcaption&gt;&lt;picture&gt;&lt;source srcset=\"//media.springernature.com/lw685/springer-static/image/art%3A10.1186%2Fs40104-024-01124-2/MediaObjects/40104_2024_1124_Fig2_HTML.png?as=webp\" type=\"image/webp\"/&gt;&lt;img alt=\"figure 2\" aria-describedby=\"Fig2\" height=\"483\" loading=\"lazy\" src=\"//media.springernature.com/lw685/springer-static/ima","PeriodicalId":14928,"journal":{"name":"Journal of Animal Science and Biotechnology","volume":"256 1","pages":""},"PeriodicalIF":7.0,"publicationDate":"2024-11-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142697113","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessment of the dietary amino acid profiles and the relative biomarkers for amino acid balance in the low-protein diets for broiler chickens","authors":"Bin Wang, Xiaodan Zhang, Yongfa Liu, Mingkun Gao, Mi Wang, Yuan Wang, Xinzhi Wang, Yuming Guo","doi":"10.1186/s40104-024-01108-2","DOIUrl":"https://doi.org/10.1186/s40104-024-01108-2","url":null,"abstract":"Research on low-protein-level diets has indicated that even though the profiles of essential amino acids (EAAs) follow the recommendation for a normal-protein-level diet, broilers fed low-protein diets failed to achieve productive performance compared to those fed normal diets. Therefore, it is imperative to reassess the optimum profile of EAAs in low-protein diets and establish a new ideal pattern for amino acid balance. Furthermore, identifying novel sensitive biomarkers for assessing amino acid balance will greatly facilitate the development of amino acid nutrition and application technology. In this study, 12 dietary treatments [Con(+), Con(-), L&A(-), L&A(+), M&C(-), M&C(+), BCAA (-), BCAA(+), Thr(-), Thr(+), Trp(-) and Trp(+)] were established by combining different EAAs including lysine and arginine, methionine and cysteine, branched-chain amino acid (BCAA), threonine, and tryptophan to observe the growth and development of the broiler chickens fed with low-protein-level diets. Based on the biochemical parameters and untargeted metabolomic analysis of animals subjected to different treatments, biomarkers associated with optimal and suboptimal amino acid balance were identified. Growth performance, carcass characteristics, hepatic enzyme activity, serum biochemical parameters, and breast muscle mRNA expression differed significantly between male and female broilers under different dietary amino acid patterns. Male broilers exhibited higher sensitivity to the adjustment of amino acid patterns than female broilers. For the low-protein diet, the dietary concentrations of lysine, arginine, and tryptophan, but not of methionine, cystine, or threonine, needed to be increased. Therefore, further research on individual BCAA is required. For untargeted metabolomic analysis, Con(+) was selected as a normal diet (NP) while Con(-) represented a low-protein diet (LP). L&A(+) denotes a low-protein amino acid balanced diet (LPAB) and Thr(+) represents a low-protein amino acid imbalance diet (LPAI). The metabolites oxypurinol, pantothenic acid, and D-octopine in birds were significantly influenced by different dietary amino acid patterns. Adjusting the amino acid profile of low-protein diets is required to achieve normal growth performance in broiler chickens fed normal-protein diets. Oxypurinol, pantothenic acid, and D-octopine have been identified as potentially sensitive biomarkers for assessing amino acid balance.","PeriodicalId":14928,"journal":{"name":"Journal of Animal Science and Biotechnology","volume":"35 1","pages":""},"PeriodicalIF":7.0,"publicationDate":"2024-11-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142610155","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}