铁下垂在猪感染和损伤中的多方面作用及其营养调节

IF 7 1区农林科学 Q1 Agricultural and Biological Sciences

Journal of Animal Science and Biotechnology Pub Date : 2025-02-25 DOI:10.1186/s40104-025-01165-1

Bei Zhou, Junjie Guo, Kan Xiao, Yulan Liu

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引用次数: 0

摘要

铁死亡是一种新发现的以铁超载和过度脂质过氧化为特征的细胞死亡。迄今为止，大量的人类和小鼠模型研究表明，铁下垂与组织损伤和各种疾病密切相关。近年来，人们也发现铁下垂在猪的感染和组织损伤中起着不可或缺的多方面作用，针对铁下垂的营养调节策略显示出巨大的潜力。本文就铁下垂及其在猪感染和组织损伤中的作用的研究进展作一综述。此外，我们还讨论了营养物质对铁下垂调节的现有证据，旨在为未来猪铁下垂的研究提供有价值的见解，并为猪感染和损伤的治疗提供新的视角。

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The multifaceted role of ferroptosis in infection and injury and its nutritional regulation in pigs

Ferroptosis is a newly identified form of regulated cell death (RCD) characterized by iron overload and excessive lipid peroxidation. To date, numerous studies in human and mouse models have shown that ferroptosis is closely related to tissue damage and various diseases. In recent years, ferroptosis has also been found to play an indispensable and multifaceted role in infection and tissue injury in pigs, and nutritional regulation strategies targeting ferroptosis show great potential. In this review, we summarize the research progress of ferroptosis and its role in infection and tissue injury in pigs. Furthermore, we discuss the existing evidence on ferroptosis regulation by nutrients, aiming to provide valuable insights for future investigation into ferroptosis in pigs and offer a novel perspective for the treatment of infection and injury in pigs.

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来源期刊

Journal of Animal Science and Biotechnology AGRICULTURE, DAIRY & ANIMAL SCIENCE-

CiteScore

9.90

自引率

2.90%

发文量

822

审稿时长

17 weeks

期刊介绍： Journal of Animal Science and Biotechnology is an open access, peer-reviewed journal that encompasses all aspects of animal science and biotechnology. That includes domestic animal production, animal genetics and breeding, animal reproduction and physiology, animal nutrition and biochemistry, feed processing technology and bioevaluation, animal biotechnology, and meat science.