Journal of applied biomedicine最新文献

{"title":"Genetic polymorphisms in the SLC27A5 gene are associated with biochemical characteristics of HBV patients in Yunnan.","authors":"Chaoqi Zhu, Qingyuan Wei, Yue Feng, Xueshan Xia, A- Mei Zhang","doi":"10.32725/jab.2026.008","DOIUrl":"https://doi.org/10.32725/jab.2026.008","url":null,"abstract":"<p><strong>Background: </strong>Lipid droplets could influence hepatitis B virus (HBV) replication and release, as well as disease progression in patients with chronic HBV. The solute carrier family 27 member 5 (SLC27A5) gene is highly expressed in the liver and possessed bile acid-CoA ligase activity. However, no previous study has investigated the role of the SLC27A5 gene in HBV infection or disease progression.</p><p><strong>Methods: </strong>A total of 400 chronic HBV patients and 300 controls were collected in Yunnan Province to genotype three single nucleotide polymorphisms (SNPs) of the SLC27A5 gene and investigate potential association between SNPs and HBV infection or biochemical characteristics of HBV patients. In silico prediction and dual-luciferase reporter assay were performed to explore the role of alleles of each SNP.</p><p><strong>Results: </strong>No association was found between HBV infection and genotypes and alleles of three SNPs (rs4801275, rs2278497, and rs56225452) in the SLC27A5 gene. However, alanine transaminase (ALT) and lymphocytes (LYM) levels differed significantly among HBV patients carrying different genotypes of rs4801275. When HBV patients were stratified into HBsAg-positive and HBsAg-negative subgroups, most hepatic functional features showed significant differences between the two subgroups. Furthermore, RNA structures containing the alleles of two SNPs were predicted, and the results indicated that different alleles could partially alter RNA structures. Dual-luciferase reporter assay also demonstrated that different alleles of the three SNPs significantly influenced firefly luciferase expression level.</p><p><strong>Conclusion: </strong>This study is the first to identify that genetic polymorphisms of the SLC27A5 gene are associated with biochemical characteristics of HBV patients in Yunnan. Furthermore, the RNA structure prediction and dual-luciferase reporter assays suggest that different alleles of the three SNPs might alter the SLC27A5 gene expression levels.</p>","PeriodicalId":14912,"journal":{"name":"Journal of applied biomedicine","volume":"24 3","pages":"93-100"},"PeriodicalIF":1.9,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149074844","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Immunogenic and cross-reactive carbohydrate determinants in ticks and other arthropods.","authors":"Jarmila Sterbova, Libor Grubhoffer, Jan Sterba","doi":"10.32725/jab.2026.003","DOIUrl":"https://doi.org/10.32725/jab.2026.003","url":null,"abstract":"<p><p>Ticks are parasites that feed on the blood of humans and animals, using it as their sole source of food. Due to their lifestyle, ticks at each life stage transmit various tick-borne pathogens while feeding on their hosts. Unlike mosquitoes - another important group of pathogen-transmitting arthropods - ticks can feed on the same host for prolonged periods, which underscores the importance of tick mechanisms that inhibit or reduce the host's defence mechanisms and, consequently, allow the transmission of pathogens. This unique tick-host-pathogen triangle requires the involvement of various tick molecules to mediate interactions with both host and pathogen molecules at multiple levels. This review highlights the glycan molecules identified in various tick species that can trigger an immune response and thus primarily affect the interaction with the host. As the enzymes involved in Golgi-mediated glycan maturation differ between ticks, insects, and their vertebrate hosts, these differences contribute to the glycan profiles observed in ticks. These differences in glycan structures influence the interactions ticks have with their hosts and pathogens. On one hand, they may participate in molecular mimicry and mechanisms that lower the host's immune reaction, blood clotting, and other defence mechanisms due to their different structures, but on the other hand they may also trigger the host's defence mechanisms, such as participating in delayed red meat allergy and facilitating the transmission of pathogens. Tick glycobiology remains largely unexplored and deserves more attention, especially considering the potential of glycans and glycoproteins as targets for anti-tick vaccines.</p>","PeriodicalId":14912,"journal":{"name":"Journal of applied biomedicine","volume":"24 2","pages":"63-71"},"PeriodicalIF":1.9,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148301913","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evidence for bidirectional gut-spleen crosstalk in rodent models: scoping review of possible mechanisms and therapeutic implications.","authors":"Teresa Lucretia, Dewi Kartikawati Paramita, Rina Susilowati","doi":"10.32725/jab.2026.006","DOIUrl":"10.32725/jab.2026.006","url":null,"abstract":"<p><strong>Introduction: </strong>The gut-spleen axis has been proposed to link the gut environment with splenic immune regulation and systemic homeostasis. This scoping review examines this interaction in rodent models.</p><p><strong>Methods: </strong>Following PRISMA-ScR guidelines, we analyzed literature (2015-2025) from PubMed, Scopus, and other major databases, including English-language rodent studies reporting gut and splenic outcomes.</p><p><strong>Results: </strong>Analysis of 48 studies suggests that gut dysbiosis may alter splenic architecture and immune function mainly via microbial metabolites, particularly short-chain fatty acids. Limited evidence indicates that splenic dysfunction could impair gut barrier integrity. Systemic stressors (e.g., infection or allergy) may reinforce this bidirectional inflammatory loop. Microbiota-targeted therapies have been observed primarily through gut-initiated mechanisms. Vagus nerve-mediated signaling points to a gut-brain-spleen network, though its directional hierarchy remains unresolved.</p><p><strong>Conclusion: </strong>Evidence supports a gut-spleen axis in rodents, with gut-derived microbial metabolites appearing to influence splenic immunity. Support for a reciprocal spleen-to-gut pathway remains limited and emergent, highlighting a research asymmetry. Together, these interactions suggest a partially bidirectional network linking the gut ecosystem to systemic immunity, with additional neural integration extending this framework toward a gut-brain-spleen axis. This integrative model proposes the gut-spleen axis as a potential therapeutic target warranting further investigation in inflammatory, metabolic, and neurological diseases.</p>","PeriodicalId":14912,"journal":{"name":"Journal of applied biomedicine","volume":"24 2","pages":"49-62"},"PeriodicalIF":1.9,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148301756","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Oxaliplatin-induced testicular toxicity is associated with transglutaminase-4 upregulation, hormonal dysregulation, and inflammatory responses.","authors":"Husah M Alowss, Ibtesam S Almami, Heba F Gomaa","doi":"10.32725/jab.2026.005","DOIUrl":"10.32725/jab.2026.005","url":null,"abstract":"<p><p>Oxaliplatin-induced toxicity presents a major challenge in cancer management because of its damaging effects on normal tissues, including the reproductive system. Transglutaminase 4 (TG4), a member of the transglutaminase enzyme family, is known for its role in protein cross-linking and cellular stress responses, but its role in chemotherapy-induced reproductive toxicity remains poorly understood. This study examines the impact of oxaliplatin, a platinum-based chemotherapeutic drug, on TG4 expression, enzymatic activity, and testicular toxicity in a rat model following intraperitoneal administration of oxaliplatin (10 mg/kg body weight weekly for six weeks). Biochemical analysis revealed significant hormonal and inflammatory alterations, including elevated serum interleukin-1β (IL-1β) levels, decreased testosterone concentrations, and increased follicle-stimulating hormone (FSH) and luteinizing hormone (LH) levels. These endocrine disturbances were accompanied by significant upregulation of TG4 expression in oxaliplatin-treated testicular tissue (OXP-TT), as demonstrated by quantitative real-time reverse transcription PCR (qRT-PCR) and immunohistochemical (IHC) analyses. Immunofluorescence (IF) further confirmed enhanced TG4 localization within both interstitial and seminiferous tubular regions. In addition, expression of the pro-inflammatory cytokines IL-6 and TNF was significantly increased. A marked elevation in total transglutaminase enzymatic activity was also detected in oxaliplatin-treated tissues. Collectively, these hormonal, inflammatory, and structural alterations occurred concurrently with increased TG4 expression and transglutaminase activity, suggesting that TG4 participates in the testicular response to oxaliplatin-induced stress. These findings indicate that TG4 is associated with chemotherapy-related reproductive toxicity and may represent a stress-responsive indicator of testicular injury. Further studies are required to determine whether TG4 plays a protective or pathogenic role in oxaliplatin-induced testicular damage and to evaluate its potential relevance in preserving fertility during platinum-based chemotherapy.</p>","PeriodicalId":14912,"journal":{"name":"Journal of applied biomedicine","volume":"24 2","pages":"81-92"},"PeriodicalIF":1.9,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148301887","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Emerging biomedical and pharmaceutical strategies for the treatment of atherosclerosis: from conventional lipid-lowering therapy to nanomedicine.","authors":"Angelika Mysliwiec, Dawid Leksa, Dorota Bartusik-Aebisher, David Aebisher","doi":"10.32725/jab.2026.007","DOIUrl":"https://doi.org/10.32725/jab.2026.007","url":null,"abstract":"<p><p>Atherosclerotic cardiovascular disease (ASCVD), including myocardial infarction and ischemic stroke, is a leading cause of death and disability worldwide and is expected to rise further by 2030. Once limited to industrialized nations, atherosclerosis has become a global issue due to the epidemiological transition from infectious to chronic metabolic diseases. Lipoproteins (chylomicrons, VLDL, LDL, HDL) and apolipoproteins play key roles in lipid metabolism and atherosclerosis development. Macrophages in plaques influence inflammation and plaque stability, with iron homeostasis also impacting disease progression. Therapies include personalized diets, statins, niacin, omega-3s, fibrates, and antiplatelet agents. Innovative strategies involve natural products and nanotechnology for targeted drug delivery, especially to macrophages and the endothelium, reducing systemic side effects. In summary, advancing therapies based on molecular insights and patient-specific factors are essential to combat this widespread chronic disease.</p>","PeriodicalId":14912,"journal":{"name":"Journal of applied biomedicine","volume":"24 2","pages":"27-48"},"PeriodicalIF":1.9,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148301720","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Five-year outcomes of posterior chamber phakic implantable collamer lens implantation in high myopia, keratoconus, and post-keratoplasty eyes.","authors":"Iveta Nemcova, Jiri Pasta, Katerina Hladikova, Martin Komarc, Darina Pospisilova, Jan Havlik, Jan Tesar, Vladimir Kratky, Martin Sin","doi":"10.32725/jab.2026.004","DOIUrl":"https://doi.org/10.32725/jab.2026.004","url":null,"abstract":"<p><strong>Purpose: </strong>To report on a 5-year follow-up of Implantable Collamer Lenses (ICL) implantation and compare it to previously published iris-fixated phakic intraocular lenses (IF pIOLs).</p><p><strong>Methods: </strong>We describe the refractive results and adverse events of 30 eyes in 18 patients with high myopia, keratoconus, or status post-keratoplasty (PKP), at one, two and five years after surgery.</p><p><strong>Results: </strong>Efficacy and safety index were 0.94 and 1.04, respectively, at 5 years after surgery. Intraocular pressure (IOP) was significantly higher postoperatively (p = 0.005). The endothelial cell loss (EC loss) caused by the ICL implantation was found to be 3.82%, 5.03%, and 11.41%, at one-, two-, and five-years post-surgery. During a 5-year follow-up, 92% of eyes lost a higher percentage of endothelial cells (EC) than the expected physiological loss. Among eyes with >25% EC loss, all affected eyes at 2 years, and 80% at 5 years, had either keratoconus or history of keratoplasty prior to ICL implantation. Postoperative EC loss positively correlated with preoperative keratometry and negatively with preoperative pachymetry. Significant inverse relationship was found between baseline and postoperative anterior chamber angle (ACA) and EC loss. Postoperative vault (388 ± 159 μm) showed a negative correlation with endothelial cell density (ECD) in 5-year follow-up. There was no cataract formation at 5 years postoperatively.</p><p><strong>Conclusion: </strong>Compared to the IF pIOLs, the V4c ICLs have similar frequency of postoperative cataract formation but appear to be safer for the endothelium. Therefore, they are likely more suitable for keratoconus and PKP patients. However, the risk of long term IOP elevation seems to be higher.</p>","PeriodicalId":14912,"journal":{"name":"Journal of applied biomedicine","volume":"24 2","pages":"72-80"},"PeriodicalIF":1.9,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148301737","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Walking the tightrope: Balancing immune checkpoints and their inhibitors in host defence against bacterial infections.","authors":"Anna Palounkova, Andrea Frejlachova, Anna Kovarikova, Ales Chrdle, Helena Langhansova","doi":"10.32725/jab.2026.001","DOIUrl":"10.32725/jab.2026.001","url":null,"abstract":"<p><p>Immune checkpoints are one of the mechanisms that maintain the balance between immunotolerance and immunopathology. These mechanisms are often exploited by tumour cells. Thanks to extensive global testing of anticancer drugs, a revolutionary cancer therapy based on immune checkpoint inhibitors (ICIs) has been developed. Some pathogens exploit regulatory checkpoint interactions, contributing to the establishment of hidden, long-term, or persistent infections in which the host is unable to eliminate the pathogen. However, a structured overview of immune checkpoint involvement in bacterial infections remains underrepresented in the current scientific literature. We conducted a literature review focusing on the documented role of selected immune checkpoints (specifically PD-1, PD-L1, TIM-3, LAG-3, CTLA-4, and TIGIT) during infections of humans and animals with clinically relevant bacterial pathogens from the Actinobacteria, Chlamydiae, Firmicutes, Proteobacteria, and Spirochaetae phyla. The current state of knowledge suggests that applied research into immune checkpoints and the controlled use of ICIs has great potential to improve the diagnosis, treatment, and prognosis of serious human bacterial infections.</p>","PeriodicalId":14912,"journal":{"name":"Journal of applied biomedicine","volume":"24 1","pages":"1-9"},"PeriodicalIF":1.9,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147529109","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"miR-500a-3p negatively regulates SOCS2 and participates in the proliferation, glycolysis, and apoptosis of HCC cells via the JAK2/STAT5 pathway.","authors":"Shan Li, Wei Luo, Wei Liu","doi":"10.32725/jab.2026.002","DOIUrl":"10.32725/jab.2026.002","url":null,"abstract":"<p><strong>Background: </strong>HCC is a prevalent malignant tumor globally with high mortality. MiR-500a-3p plays critical roles in tumorigenesis and tumor progression.</p><p><strong>Methods: </strong>To evaluate miR-500a-3p's role in HCC, we first analyzed its expression and prognostic value via qRT-PCR and TCGA (Kaplan-Meier analysis). We then performed extensive in vitro functional studies after cell transfection (mimics, anti-miR, SOCS2 OE), measuring proliferation, migration, invasion, glycolytic parameters (glucose consumption, lactate, ECAR, ATP), and apoptosis. A target relationship with SOCS2 was predicted bioinformatically and confirmed by dual-luciferase assay. Using the JAK2/STAT5 signaling pathway inhibitor Fedratinib, the activator Erythropoietin, and transfection with si-STAT5 and oe-STAT5, the molecular mechanism of miR-500a-3p in HCC was investigated. In vivo experiments established tumor-bearing mouse models to evaluate the effect of miR-500a-3p on tumor growth.</p><p><strong>Results: </strong>miR-500a-3p was significantly upregulated in HCC tissues and cells, and was associated with poor patient prognosis. The overexpression of miR-500a-3p promotes the malignant progression of HCC cells. Mechanistically, miR-500a-3p directly targeted and negatively regulated SOCS2 expression. SOCS2 expression was suppressed in HCC, with its expression abrogating miR-500a-3p-mediated oncogenicity. miR-500a-3p activated the JAK2/STAT5 pathway by inhibiting SOCS2, thereby regulating the malignant biological behaviors of HCC cells. Both SOCS2 overexpression and JAK2 inhibitor treatment could reverse the activation of the JAK2/STAT5 axis and downstream effects induced by miR-500a-3p. MiR-500a-3p promoted tumor growth in tumor-bearing mice, accompanied by SOCS2 downregulation and JAK2/STAT5 pathway activation.</p><p><strong>Conclusion: </strong>This study reveals that miR-500a-3p promotes proliferation and glycolysis while inhibiting apoptosis of HCC cells by negatively regulating SOCS2 and activating the JAK2/STAT5 pathway.</p>","PeriodicalId":14912,"journal":{"name":"Journal of applied biomedicine","volume":"24 1","pages":"10-26"},"PeriodicalIF":1.9,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147529125","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Propofol suppresses breast cancer invasion: An in vitro three-dimensional cell invasion model with microfluidic technology.","authors":"Zhitong Wan, Haoyue Lyu, Yuting Luo, Tong Liu, Xiaoyu Peng, Yijing Zhang, Yuan Li","doi":"10.32725/jab.2025.019","DOIUrl":"https://doi.org/10.32725/jab.2025.019","url":null,"abstract":"<p><p>The fundamental aspect of breast cancer metastasis is the infiltration of malignant cells, which can be blocked by propofol, a widely utilized anesthetic in clinical settings, as recent studies reporting. However, research utilizing three-dimensional invasion models in vitro has not been documented. This study created a microfluidic chip model utilizing type I collagen (Col1), integrating delayed dynamic imaging and several fluorescence labeling approaches to objectively assess the inhibitory effect of propofol on breast cancer cell MDA-MB-231 invasion. Research indicates that MDA-MB-231 cells demonstrate collective invasion behavior, with their invasive capacity reliant on the degradation of the extracellular matrix (ECM) facilitated by matrix metalloproteinases (MMPs): both the invasion distance and cell count diminish as matrix hardness (collagen concentration 1-2.5 mg/ml) increases, while they augment with extended culture duration (1-5 days). Subsequent research has demonstrated that propofol (12.5-50 μg/ml) can reduce both the invasion distance and quantity of MDA-MB-231 cells in a dose-dependent manner, potentially linked to the down-regulation of MMP-2/MMP-9 and the up-regulation of tissue inhibitor of metalloproteinase-1 (TIMP-1) expression. This paper presents novel experimental evidence that propofol inhibits the invasion of breast cancer cells, and establishes a straightforward and quantitative medication evaluation platform, offering a methodological reference for the screening and mechanistic investigation of tumor microenvironment regulators.</p>","PeriodicalId":14912,"journal":{"name":"Journal of applied biomedicine","volume":"23 4","pages":"174-183"},"PeriodicalIF":2.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145768101","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Relationship between interleukin-37 genetic polymorphisms and HBV-related liver disease in a Chinese Han cohort.","authors":"Ping Fang, Ping Meng, Lijun Du, Hui Li, Rong Wang, Juan Zhao, Decheng Cai","doi":"10.32725/jab.2025.017","DOIUrl":"10.32725/jab.2025.017","url":null,"abstract":"<p><p>Hepatitis B virus (HBV)-related liver disease is an inflammatory-associated disease, with diverse clinical phenotypes ranging from asymptomatic HBV carriers to hepatocellular carcinoma. Interleukin-37 (IL-37), a cytokine that effectively inhibits innate and adaptive immunity, has powerful anti-inflammatory and anti-tumor effects. Several single nucleotide polymorphisms (SNPs) in the IL37 gene are genetic predictive risk factors for HBV infection and HBV-mediated liver disease progression. However, different ethnic groups may have different allele frequencies and linkage disequilibrium structures. The effect of SNPs in IL37 on HBV infection and its relationship with different clinical outcomes have not been clarified among the Han people in southern China. Based on in silico functional prediction and previously reported in the literature to be potentially associated with diseases, we screened seven potentially functional SNPs (rs3811046, rs3811047, rs2723176, rs2723186, rs4611652, rs4392270, and rs4241122) located in the IL37 genomic region and 3-kb upstream and downstream of the gene body. 1,582 subjects were included in the study, including 747 patients with HBV-related liver disease, 405 patients who cleared HBV, and 430 healthy controls. The seven SNPs were genotyped using the SNaPshot SNP assay, and co-dominant, dominant, and recessive models were used to explore the association of each SNP with HBV infection and clinical outcomes after HBV infection. The rs4241122 demonstrated a significant association with both HBV infection and its clinical outcomes, with the GG genotype identified as an independent protective factor for spontaneous clearance of HBV. The rs2723186 and rs4392270 were also significantly associated with HBV clearance under specific genetic models. Furthermore, rs3811046 and rs3811047 were correlated with the progression of liver abnormalities following HBV infection. Our data suggests that SNPs at the IL37 locus are associated with susceptibility to HBV infection and clinical outcomes after HBV infection.</p>","PeriodicalId":14912,"journal":{"name":"Journal of applied biomedicine","volume":"23 4","pages":"184-196"},"PeriodicalIF":2.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145768174","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}