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Selected widely prescribed pharmaceuticals: toxicity of the drugs and the products of their photochemical degradation to aquatic organisms. 部分广泛使用的药物：药物及其光化学降解产物对水生生物的毒性。
IF 1.3 4区 医学
Journal of applied biomedicine Pub Date : 2024-03-01 Epub Date: 2024-03-13 DOI: 10.32725/jab.2024.007
Sarka Klementova, Martina Poncarova
{"title":"Selected widely prescribed pharmaceuticals: toxicity of the drugs and the products of their photochemical degradation to aquatic organisms.","authors":"Sarka Klementova, Martina Poncarova","doi":"10.32725/jab.2024.007","DOIUrl":"https://doi.org/10.32725/jab.2024.007","url":null,"abstract":"<p><p>Cholesterol-lowering drugs, antidiabetics, antiarrhythmics, antidepressants, and antibiotics belong to the most prescribed drugs worldwide. Because of the manufacture, excretion, and improper disposal of leftover drugs, the drugs enter waste waters and, subsequently, surface waters. They have been detected in surface waters all over the world, from concentrations of ng/l to concentrations several orders of magnitude higher. Since pharmaceuticals are designed to be both biologically and chemically stable, photochemical degradation by sun radiation represents a way of transformation in the natural environment. This review provides a survey of how selected drugs of the above-mentioned classes affect aquatic organisms of different trophic level. The emphasis is on the harmful effects of phototransformation products, an area of scientific investigation that has only attracted attention in the past few years, revealing the surprising fact that products of photochemical degradation might be even more toxic to aquatic organisms than the parent drugs.</p>","PeriodicalId":14912,"journal":{"name":"Journal of applied biomedicine","volume":null,"pages":null},"PeriodicalIF":1.3,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140174808","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Amelioration of obesity induction by a high-fat diet and related inflammation by Phasa fish (Setipinna phasa) oil in BALB/c mice 法鲨鱼（Setipinna phasa）油改善高脂饮食诱发 BALB/c 小鼠的肥胖症及相关炎症
IF 1.3 4区 医学
Journal of applied biomedicine Pub Date : 2024-02-14 DOI: 10.32725/jab.2024.003
Titli Panchali, Ananya Dutta, Pipika Das, Amina Khatun, Riya Kar, S. Mondal, K. C. Mondal, Sudipta Chakrabarti, Kuntal Ghosh, Shrabani Pradhan
{"title":"Amelioration of obesity induction by a high-fat diet and related inflammation by Phasa fish (Setipinna phasa) oil in BALB/c mice","authors":"Titli Panchali, Ananya Dutta, Pipika Das, Amina Khatun, Riya Kar, S. Mondal, K. C. Mondal, Sudipta Chakrabarti, Kuntal Ghosh, Shrabani Pradhan","doi":"10.32725/jab.2024.003","DOIUrl":"https://doi.org/10.32725/jab.2024.003","url":null,"abstract":"","PeriodicalId":14912,"journal":{"name":"Journal of applied biomedicine","volume":null,"pages":null},"PeriodicalIF":1.3,"publicationDate":"2024-02-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139777436","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Anti-inflammatory effect of luteoloside against methylglyoxal induced human dental pulp cells 木犀草苷对甲基乙二醛诱导的人牙髓细胞的抗炎作用
IF 1.3 4区 医学
Journal of applied biomedicine Pub Date : 2024-02-14 DOI: 10.32725/jab.2024.002
Kim Ji-Eun, Pradhan Paras Man, Sungil Jang, Ho-Keun Yi
{"title":"Anti-inflammatory effect of luteoloside against methylglyoxal induced human dental pulp cells","authors":"Kim Ji-Eun, Pradhan Paras Man, Sungil Jang, Ho-Keun Yi","doi":"10.32725/jab.2024.002","DOIUrl":"https://doi.org/10.32725/jab.2024.002","url":null,"abstract":"","PeriodicalId":14912,"journal":{"name":"Journal of applied biomedicine","volume":null,"pages":null},"PeriodicalIF":1.3,"publicationDate":"2024-02-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139837002","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Amelioration of obesity induction by a high-fat diet and related inflammation by Phasa fish (Setipinna phasa) oil in BALB/c mice 法鲨鱼（Setipinna phasa）油改善高脂饮食诱发 BALB/c 小鼠的肥胖症及相关炎症
IF 1.3 4区 医学
Journal of applied biomedicine Pub Date : 2024-02-14 DOI: 10.32725/jab.2024.003
Titli Panchali, Ananya Dutta, Pipika Das, Amina Khatun, Riya Kar, S. Mondal, K. C. Mondal, Sudipta Chakrabarti, Kuntal Ghosh, Shrabani Pradhan
{"title":"Amelioration of obesity induction by a high-fat diet and related inflammation by Phasa fish (Setipinna phasa) oil in BALB/c mice","authors":"Titli Panchali, Ananya Dutta, Pipika Das, Amina Khatun, Riya Kar, S. Mondal, K. C. Mondal, Sudipta Chakrabarti, Kuntal Ghosh, Shrabani Pradhan","doi":"10.32725/jab.2024.003","DOIUrl":"https://doi.org/10.32725/jab.2024.003","url":null,"abstract":"","PeriodicalId":14912,"journal":{"name":"Journal of applied biomedicine","volume":null,"pages":null},"PeriodicalIF":1.3,"publicationDate":"2024-02-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139836818","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Endoplasmic reticulum stress-related protein GRP78 and CHOP levels in synovial fluid correlate with disease progression of primary knee osteoarthritis: A cross-sectional study 滑液中的内质网应激相关蛋白GRP78和CHOP水平与原发性膝骨关节炎的疾病进展相关：横断面研究
IF 1.3 4区 医学
Journal of applied biomedicine Pub Date : 2024-01-19 DOI: 10.32725/jab.2024.001
Dan-Dan Liu, Yuan-Chuang Zhao, Hai-hong Li, Lian-Jun Yin, Jun-Qi Chen, Gang Liu
{"title":"Endoplasmic reticulum stress-related protein GRP78 and CHOP levels in synovial fluid correlate with disease progression of primary knee osteoarthritis: A cross-sectional study","authors":"Dan-Dan Liu, Yuan-Chuang Zhao, Hai-hong Li, Lian-Jun Yin, Jun-Qi Chen, Gang Liu","doi":"10.32725/jab.2024.001","DOIUrl":"https://doi.org/10.32725/jab.2024.001","url":null,"abstract":"","PeriodicalId":14912,"journal":{"name":"Journal of applied biomedicine","volume":null,"pages":null},"PeriodicalIF":1.3,"publicationDate":"2024-01-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139525206","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Olfactory event-related potentials (OERPs) and trigeminal event-related potentials (TERPs) - a pilot study in Czech participants with normal sense of smell 嗅觉事件相关电位（OERPs）和三叉神经事件相关电位（TERPs）--对嗅觉正常的捷克参与者进行的试点研究
IF 1.3 4区 医学
Journal of applied biomedicine Pub Date : 2023-12-07 DOI: 10.32725/jab.2023.020
Richard Holý, K. Janoušková, L. Vašina, Eva Maute, David Kalfeřt, Kristýna Mamiňák, Eva Augste, Jiří Hložek, Helene Schulz, David Funda, Jaromír Astl
{"title":"Olfactory event-related potentials (OERPs) and trigeminal event-related potentials (TERPs) - a pilot study in Czech participants with normal sense of smell","authors":"Richard Holý, K. Janoušková, L. Vašina, Eva Maute, David Kalfeřt, Kristýna Mamiňák, Eva Augste, Jiří Hložek, Helene Schulz, David Funda, Jaromír Astl","doi":"10.32725/jab.2023.020","DOIUrl":"https://doi.org/10.32725/jab.2023.020","url":null,"abstract":"","PeriodicalId":14912,"journal":{"name":"Journal of applied biomedicine","volume":null,"pages":null},"PeriodicalIF":1.3,"publicationDate":"2023-12-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138590839","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Effect of Usnea longissima ethyl acetate extract on acute oxidative and inflammatory lung damage from Staphylococcus aureus infection in rats 长叶乌贼碱乙酸乙酯提取物对金黄色葡萄球菌感染大鼠肺部急性氧化和炎症损伤的影响
IF 1.3 4区 医学
Journal of applied biomedicine Pub Date : 2023-12-07 DOI: 10.32725/jab.2023.022
B. Dabanlioglu, B. Suleyman, R. Mammadov, Bulent Yavuzer, Sumeyye Akyuz, Onder Akkas, Behzad Mokhtare, E. A. Turumtay, D. Altuner, Taha Abdulkadir Coban, H. Suleyman
{"title":"Effect of Usnea longissima ethyl acetate extract on acute oxidative and inflammatory lung damage from Staphylococcus aureus infection in rats","authors":"B. Dabanlioglu, B. Suleyman, R. Mammadov, Bulent Yavuzer, Sumeyye Akyuz, Onder Akkas, Behzad Mokhtare, E. A. Turumtay, D. Altuner, Taha Abdulkadir Coban, H. Suleyman","doi":"10.32725/jab.2023.022","DOIUrl":"https://doi.org/10.32725/jab.2023.022","url":null,"abstract":"","PeriodicalId":14912,"journal":{"name":"Journal of applied biomedicine","volume":null,"pages":null},"PeriodicalIF":1.3,"publicationDate":"2023-12-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138591337","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Naringin inhibits P2X4 receptor expression on satellite glial cells in the neonatal rat dorsal root ganglion 柚皮素抑制新生大鼠背根神经节卫星神经胶质细胞上 P2X4 受体的表达
IF 1.3 4区 医学
Journal of applied biomedicine Pub Date : 2023-12-04 DOI: 10.32725/jab.2023.021
Hongji Wang, Lisha Chen, Juping Xing, Xiangchao Shi, Changshui Xu
{"title":"Naringin inhibits P2X4 receptor expression on satellite glial cells in the neonatal rat dorsal root ganglion","authors":"Hongji Wang, Lisha Chen, Juping Xing, Xiangchao Shi, Changshui Xu","doi":"10.32725/jab.2023.021","DOIUrl":"https://doi.org/10.32725/jab.2023.021","url":null,"abstract":"","PeriodicalId":14912,"journal":{"name":"Journal of applied biomedicine","volume":null,"pages":null},"PeriodicalIF":1.3,"publicationDate":"2023-12-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138605101","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Ginsenoside Rb2 improves heart failure by down-regulating miR-216a-5p to promote autophagy and inhibit apoptosis and oxidative stress. 人参皂苷Rb2通过下调miR-216a-5p来促进自噬、抑制细胞凋亡和氧化应激，从而改善心力衰竭。
IF 1.3 4区 医学
Journal of applied biomedicine Pub Date : 2023-12-01 Epub Date: 2023-12-14 DOI: 10.32725/jab.2023.024
You Peng, Bin Liao, Yan Zhou, Wei Zeng
{"title":"Ginsenoside Rb2 improves heart failure by down-regulating miR-216a-5p to promote autophagy and inhibit apoptosis and oxidative stress.","authors":"You Peng, Bin Liao, Yan Zhou, Wei Zeng","doi":"10.32725/jab.2023.024","DOIUrl":"10.32725/jab.2023.024","url":null,"abstract":"<p><strong>Background: </strong>Ginsenoside Rb2 is beneficial in cardiovascular disease treatment, yet its role in heart failure (HF) is obscure. This study aimed to investigate the effect and mechanism of ginsenoside Rb2 on HF.</p><p><strong>Methods: </strong>The left anterior descending branch-ligated HF rat model and oxygen-glucose deprivation/reoxygenation (OGD/R) H9c2 cell model were constructed. Ginsenoside Rb2 were applied for intervention. Heart function indexes, miR-216a-5p expression, autophagy, oxidative stress, apoptosis, cell morphology, and proliferation were detected to explore the effect of ginsenoside Rb2 on HF. Overexpression of miR-216a-5p was employed to explore the specific mechanism of ginsenoside Rb2 on HF.</p><p><strong>Results: </strong>Ginsenoside Rb2 improved the heart function of HF rats, including the reduction of heart rate, LVEDP, and heart weight/body weight ratio, and the increase of LVSP, +dP/dtmax, -dP/dtmax, LVEF, and LVFS. It also down-regulated miR-216a-5p expression and enhanced OGD/R-induced cardiomyocyte viability. Ginsenoside Rb2 up-regulated Bcl2, LC3B II/I, and Beclin1, and down-regulated Bax, Caspase-3, and p62 in the myocardium of HF rats and OGD/R-induced H9c2 cells. Moreover, ginsenoside Rb2 increased the levels of SOD and CAT, but decreased the levels of MDA and ROS in the myocardium of HF rats and OGD/R-induced H9c2 cells. However, overexpression of miR-216a-5p promoted the apoptosis and oxidative stress of cardiomyocytes and inhibited autophagy, thus reversing the therapeutic effect of ginsenoside Rb2 on HF in vivo and in vitro.</p><p><strong>Conclusion: </strong>Ginsenoside Rb2 demonstrated potential as a therapeutic intervention for HF by enhancing autophagy and reducing apoptosis and oxidative stress through miR-216a-5p downregulation. Further research could explore its application in clinical trials and investigate the complex mechanism networks underlying its effects.</p>","PeriodicalId":14912,"journal":{"name":"Journal of applied biomedicine","volume":null,"pages":null},"PeriodicalIF":1.3,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138804998","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Shenhuang plaster enhances intestinal anastomotic healing in rabbits through activation of the TGF-β and Hippo/YAP signaling pathways. 神黄膏药通过激活 TGF-β 和 Hippo/YAP 信号通路促进家兔肠吻合口愈合
IF 1.3 4区 医学
Journal of applied biomedicine Pub Date : 2023-12-01 Epub Date: 2023-11-15 DOI: 10.32725/jab.2023.018
Fengchun Xiao, Chenchen Zhu, Xing Wei, Guiping Chen, Xiaohong Xu
{"title":"Shenhuang plaster enhances intestinal anastomotic healing in rabbits through activation of the TGF-β and Hippo/YAP signaling pathways.","authors":"Fengchun Xiao, Chenchen Zhu, Xing Wei, Guiping Chen, Xiaohong Xu","doi":"10.32725/jab.2023.018","DOIUrl":"10.32725/jab.2023.018","url":null,"abstract":"<p><p>Although many efforts have been made to improve management strategies and diagnostic methods in the past several decades, the prevention of anastomotic complications, such as anastomotic leaks and strictures, remain a major clinical challenge. Therefore, new molecular pathways need to be identified that regulate anastomotic healing, and to design new treatments for patients after anastomosis to reduce the occurrence of complications. Rabbits were treated with a MST1/2 inhibitor XMU-XP-1, a Chinese medicine formula Shenhuang plaster (SHP) or a control vehicle immediately after surgery. The anastomotic burst pressure, collagen deposition, and hydroxyproline concentration were evaluated at 3 and 7 days after the surgery, and qRT-PCR and western-blot analyses were used to characterize mRNA and protein expression levels. Both XMU-XP-1 and SHP significantly increased anastomotic burst pressure, collagen deposition, and the concentration of hydroxyproline in intestinal anastomotic tissue at postoperative day 7 (POD 7). Importantly, SHP could induce TGF-β1 expression, which activated its downstream target Smad-2 to activate the TGF-β1 signaling pathway. Moreover, SHP reduced the phosphorylation level of YAP and increased its active form, and treatment with verteporfin, a YAP-TEAD complex inhibitor, significantly suppressed the effects induced by SHP during anastomotic tissue healing. This study demonstrated that activation of the Hippo-YAP pathway enhances anastomotic healing, and that SHP enhances both the TGF-β1/Smad and YAP signaling pathways to promote rabbit anastomotic healing after surgery. These results suggest that SHP could be used to treat patients who underwent anastomosis to prevent the occurrence of anastomotic complications.</p>","PeriodicalId":14912,"journal":{"name":"Journal of applied biomedicine","volume":null,"pages":null},"PeriodicalIF":1.3,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138805000","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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