Olfactory event-related potentials (OERPs) and trigeminal event-related potentials (TERPs) in subjects after Covid-19 infection: single-center prospective study.

IF 2 4区医学 Q3 MEDICINE, RESEARCH & EXPERIMENTAL

Journal of applied biomedicine Pub Date : 2024-09-01 Epub Date: 2024-09-23 DOI:10.32725/jab.2024.020

Richard Holy, David Kalfert, Libor Vasina, Oleksii Vorobiov, Petra Dytrych, Karla Janouskova, Eva Augste, Shahriar Kashiri, Nikola Pastorkova, Kristyna Miminak, Jiri Hlozek, Daniel Kovar, Jan Vodicka, Jaromir Astl

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引用次数: 0

Abstract

Objectives: Olfactory dysfunction (OD) is a common symptom associated with Covid-19. During the Covid-19 pandemic, the importance of psychophysical olfactory tests and electrophysiological olfactory assessment increased. The purpose of the study was to analyze the psychophysical olfactory tests and the post-covid curves of olfactory event-related potentials (OERPs) and trigeminal event-related potentials (TERPs).

Methods: The prospective study included 98 subjects (62 females / 36 males). The average age was 42 years (range 21-84 years). Group I (n = 77) contained participants who had been infected with Covid-19. They were enrolled in the study at least 1 year after Covid-19. Group II (n = 21) was the healthy normosmic control group.

Results: In Group I, the OERPs of 18% participants were absent. Patients in Group I were statistically more likely to have an absence of OERPs (p = 0.036) than subjects in Group II. We did not detect a statistical difference in amplitudes and latencies of the OERPs between Group I and Group II. In Group I, N1 latency of the TERPs was significantly longer (p = 0.002) than in Group II. The amplitude of the N1-P2 interval of the TERPs was significantly lower (p = 0.025) in Group I than in Group II. According to the psychophysical Sniffin stick identification test, hyposmia was detected in 39% in Group I versus 0% in the control Group II.

Conclusion: OD is a common post-covid symptom. The presence of OERPs is a significant prognostic factor for olfactory function after Covid 19. We detected a lower percentage of absence of OERPs after Covid-19 compared to the previously published studies of post-viral OD and post-infectious OD. For TERPs, we detected a longer N1 latency and a lower amplitude for the N1-P2 interval after Covid-19. OERPs and TERPs can be considered valid biomarkers to evaluate the progress of post-covid OD.

查看原文本刊更多论文

感染 Covid-19 后受试者的嗅觉事件相关电位 (OERP) 和三叉神经事件相关电位 (TERP)：单中心前瞻性研究。

目的：嗅觉功能障碍（OD）是与 Covid-19 相关的常见症状。在 Covid-19 大流行期间，心理物理嗅觉测试和电生理嗅觉评估的重要性有所增加。研究的目的是分析心理物理嗅觉测试以及Covid-19后嗅觉事件相关电位（OERPs）和三叉神经事件相关电位（TERPs）的曲线：这项前瞻性研究包括 98 名受试者（62 名女性/36 名男性）。平均年龄为 42 岁（21-84 岁不等）。第一组（n = 77）的受试者感染了 Covid-19。他们在感染 Covid-19 病毒至少 1 年后才被纳入研究。第二组（21 人）为健康正常对照组：结果：在第一组中，有 18% 的参与者没有 OERPs。与第二组相比，第一组患者出现 OERPs 缺失的概率更高（p = 0.036）。我们没有发现第一组和第二组之间在 OERPs 的振幅和潜伏期方面存在统计学差异。在第一组中，TERPs 的 N1 潜伏期明显长于第二组（p = 0.002）。第一组 TERPs 的 N1-P2 间期振幅明显低于第二组（p = 0.025）。根据心理物理嗅棒识别测试，Ⅰ组有 39% 的人检测到嗅觉减退，而对照组Ⅱ为 0%：结论：OD是一种常见的性高潮后症状。结论：嗅觉减退症是科维德治疗后的常见症状，OERPs的存在是科维德治疗后嗅觉功能的重要预后因素。与之前发表的病毒后 OD 和感染后 OD 研究相比，我们发现 Covid-19 后 OERPs 的缺失比例较低。在 TERPs 方面，我们检测到 Covid-19 后的 N1 潜伏期更长，N1-P2 间期的振幅更低。OERPs和TERPs可被视为评估病毒后OD进展的有效生物标志物。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of applied biomedicine PHARMACOLOGY & PHARMACY-

CiteScore

2.40

自引率

7.70%

发文量

审稿时长

>12 weeks

期刊介绍： Journal of Applied Biomedicine promotes translation of basic biomedical research into clinical investigation, conversion of clinical evidence into practice in all medical fields, and publication of new ideas for conquering human health problems across disciplines. Providing a unique perspective, this international journal publishes peer-reviewed original papers and reviews offering a sensible transfer of basic research to applied clinical medicine. Journal of Applied Biomedicine covers the latest developments in various fields of biomedicine with special attention to cardiology and cardiovascular diseases, genetics, immunology, environmental health, toxicology, neurology and oncology as well as multidisciplinary studies. The views of experts on current advances in nanotechnology and molecular/cell biology will be also considered for publication as long as they have a direct clinical impact on human health. The journal does not accept basic science research or research without significant clinical implications. Manuscripts with innovative ideas and approaches that bridge different fields and show clear perspectives for clinical applications are considered with top priority.