Unlocking the secrets of aortic pseudoaneurysms - exploring tensile testing of prostheses, anastomoses, and native vessels in the thoracic aorta: A clinical-engineering correlation.

IF 2 4区 医学 Q3 MEDICINE, RESEARCH & EXPERIMENTAL
Journal of applied biomedicine Pub Date : 2025-06-01 Epub Date: 2025-06-20 DOI:10.32725/jab.2025.008
Sandra Recicarova, Hynek Chlup, Michael Jonak, Ivan Netuka
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引用次数: 0

Abstract

Introduction: This study examines the mechanical properties of thoracic aortic false aneurysms (TAFA) and how the use of vascular prostheses, native vessels, and anastomoses affects their development. This is done through tensile testing, simulating a Bentall procedure, which is the most common surgery leading to TAFA development.

Methods: We conducted uniaxial tensile tests on the native right and left coronary arteries from five cadaveric donors. They were anastomosed to two vascular prostheses in the longitudinal and circumferential directions to assess their mechanical responses under load.

Results and discussion: All anastomosis specimens ruptured on the native vessel side, with no breaches occurring on the prosthesis side. The P2 prosthesis exhibited a mechanical response closer to that of the native vessel compared to the P1 prosthesis. There were no statistically significant differences in wall thickness or mechanical properties between the left and right coronary artery samples, leading to the merging of these groups. The strain of the anastomosis in the longitudinal direction was significantly higher than in the circumferential direction. In both directions, the strain at the onset of rupture was greater than that of the native vessel, with a particularly notable difference in the longitudinal direction. Although there was no significant difference in stress values between the longitudinal and circumferential directions, forces per suture were slightly higher in the circumferential direction.

Conclusion: Using the "endo-button buttress technique" with a double-layer anastomosis can help distribute the load and reduce stress. An alternative option is to use a Carrel patch to reinforce the connection between the target site and the conduit. Additionally, autologous pericardium can be employed for reinforcement.

解开主动脉假性动脉瘤的秘密——探索胸主动脉假体、吻合口和原生血管的张力测试:临床工程相关性。
简介:本研究探讨胸主动脉假性动脉瘤(TAFA)的力学特性,以及血管假体、原生血管和吻合口的使用如何影响其发展。这是通过拉伸测试来完成的,模拟Bentall手术,这是最常见的导致TAFA发展的手术。方法:对5例尸体供体的左、右冠状动脉进行单轴拉伸试验。他们在纵向和周向两个血管假体上吻合,以评估他们在载荷下的力学反应。结果与讨论:所有吻合标本均在原生血管侧破裂,假体侧无破裂。与P1假体相比,P2假体表现出更接近原生血管的机械反应。左、右冠状动脉样本的壁厚和力学性能没有统计学上的显著差异,导致这两组合并。吻合口纵向应变明显高于周向应变。在两个方向上,破裂开始时的应变都大于原生血管的应变,在纵向上的差异尤为显著。虽然纵向和周向的应力值没有显著差异,但每条缝线在周向的受力略高。结论:采用双层吻合的“内扣支撑技术”可有效分散负荷,减轻应力。另一种选择是使用卡雷尔贴片来加强目标部位和导管之间的连接。此外,自体心包可用于加固。
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来源期刊
Journal of applied biomedicine
Journal of applied biomedicine PHARMACOLOGY & PHARMACY-
CiteScore
2.40
自引率
7.70%
发文量
13
审稿时长
>12 weeks
期刊介绍: Journal of Applied Biomedicine promotes translation of basic biomedical research into clinical investigation, conversion of clinical evidence into practice in all medical fields, and publication of new ideas for conquering human health problems across disciplines. Providing a unique perspective, this international journal publishes peer-reviewed original papers and reviews offering a sensible transfer of basic research to applied clinical medicine. Journal of Applied Biomedicine covers the latest developments in various fields of biomedicine with special attention to cardiology and cardiovascular diseases, genetics, immunology, environmental health, toxicology, neurology and oncology as well as multidisciplinary studies. The views of experts on current advances in nanotechnology and molecular/cell biology will be also considered for publication as long as they have a direct clinical impact on human health. The journal does not accept basic science research or research without significant clinical implications. Manuscripts with innovative ideas and approaches that bridge different fields and show clear perspectives for clinical applications are considered with top priority.
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