Distribution of human leukocyte antigen B27 (HLA-B27) in Slovak patients.

IF 2 4区医学 Q3 MEDICINE, RESEARCH & EXPERIMENTAL

Journal of applied biomedicine Pub Date : 2025-03-01 Epub Date: 2025-03-25 DOI:10.32725/jab.2025.004

Alexandra Pobisova, Andrea Kollarova, Vladimir Langraf, Frantisek Strejcek, Ramona Babosova

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引用次数: 0

Abstract

Background and objectives: HLA-B27 is a genetic marker associated with spondyloarthropathies, particularly ankylosing spondylitis and axial spondyloarthritis. While its prevalence varies across populations, no data exist for Slovak patients. This study aimed to determine HLA-B27 prevalence in Slovak patients with suspected spondyloarthropathies and assess differences by sex and age.

Methods: A retrospective cohort of 1,614 patients (888 females and 726 males) was analyzed for HLA-B27 status (positive/negative) using reverse hybridisation (HLA-B27 StripAssay). Statistical analyses included Pearson's Chi-square test and non-parametric Mann-Whitney U and Kruskal-Wallis tests for sex- and age-related differences.

Results: HLA-B27 positivity was 20.57%, with a higher proportion in males (23.28%) than females (18.36%, p = 0.0177). The less than 20 age group had the highest absolute number of positive cases (126 cases; 17.80%), while the 21-40 group had the highest relative positivity (119 cases; 29.38%). The lowest positivity was in the more than 61 age group (17 cases; 13.08%), though age distribution differences were not statistically significant (p = 0.7765). Positivity varies across diagnoses, peaking in musculoskeletal (M) and eye disorders (H), where it exceeds 29%.

Conclusion: HLA-B27 positivity is strongly associated with rheumatologic and ophthalmologic conditions and exhibits age- and sex-related variability. These findings emphasize the diagnostic significance of HLA-B27 testing in Slovak patients, especially for early detection and management of spondyloarthropathies. Further research on HLA-B27 variability and its clinical implications is needed to optimize diagnostic strategies and patient care.

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人白细胞抗原B27 （HLA-B27）在斯洛伐克患者中的分布。

背景和目的：HLA-B27是一种与脊椎关节病，特别是强直性脊柱炎和轴性脊柱炎相关的遗传标记。虽然其患病率因人群而异，但没有斯洛伐克患者的数据。本研究旨在确定HLA-B27在斯洛伐克疑似脊椎关节病患者中的患病率，并评估性别和年龄的差异。方法：对1614例患者（女性888例，男性726例）的HLA-B27状态（阳性/阴性）进行反向杂交（HLA-B27 StripAssay）分析。统计分析包括皮尔逊卡方检验和非参数Mann-Whitney U和Kruskal-Wallis检验，用于性别和年龄相关的差异。结果：HLA-B27阳性率为20.57%，男性阳性率（23.28%）高于女性（18.36%），p = 0.0177。20岁以下年龄组阳性病例绝对数量最多(126例；17.80%)， 21 ~ 40岁组相对阳性率最高(119例；29.38%)。61岁以上年龄组阳性率最低(17例；13.08%)，但年龄分布差异无统计学意义（p = 0.7765）。在不同的诊断中，阳性程度有所不同，在肌肉骨骼疾病(M)和眼部疾病(H)中达到顶峰，超过29%。结论：HLA-B27阳性与风湿病和眼科疾病密切相关，并表现出年龄和性别相关的变异性。这些研究结果强调了HLA-B27检测在斯洛伐克患者中的诊断意义，特别是对于脊椎关节病的早期发现和治疗。需要进一步研究HLA-B27变异及其临床意义，以优化诊断策略和患者护理。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of applied biomedicine PHARMACOLOGY & PHARMACY-

CiteScore

2.40

自引率

7.70%

发文量

审稿时长

>12 weeks

期刊介绍： Journal of Applied Biomedicine promotes translation of basic biomedical research into clinical investigation, conversion of clinical evidence into practice in all medical fields, and publication of new ideas for conquering human health problems across disciplines. Providing a unique perspective, this international journal publishes peer-reviewed original papers and reviews offering a sensible transfer of basic research to applied clinical medicine. Journal of Applied Biomedicine covers the latest developments in various fields of biomedicine with special attention to cardiology and cardiovascular diseases, genetics, immunology, environmental health, toxicology, neurology and oncology as well as multidisciplinary studies. The views of experts on current advances in nanotechnology and molecular/cell biology will be also considered for publication as long as they have a direct clinical impact on human health. The journal does not accept basic science research or research without significant clinical implications. Manuscripts with innovative ideas and approaches that bridge different fields and show clear perspectives for clinical applications are considered with top priority.