{"title":"Is the capacity to consent different from the capacity to refuse treatments and procedures in adolescence?","authors":"Guilherme Henrique Martins, Kalline Eler, Aline Albuquerque, Rui Nunes","doi":"10.1016/j.jped.2025.04.004","DOIUrl":"https://doi.org/10.1016/j.jped.2025.04.004","url":null,"abstract":"<p><strong>Objective: </strong>The objective of this article is to broaden the discussion on the factors that constitute adolescent healthcare decisional capacity, ensuring that adolescents are recognized as capable of refusing treatments or procedures.</p><p><strong>Sources: </strong>Materials from different sources were analyzed, including articles from reputable databases and documents from government agencies, forming a purposefully selected sample. The research was conducted in two phases: document selection and reflective analysis, followed by a report. The discussion was approached from a phenomenological perspective, with reflections grounded in human rights principles.</p><p><strong>Summary of the findings: </strong>Healthcare decisional capacity must be sufficiently robust to allow adolescents to refuse treatments or procedures. It is essential to respect the right of capable adolescents to refuse treatments and procedures. Protecting the vulnerability of adolescent patients involves honoring their growing autonomy. Data from field research regarding the refusal of treatments and procedures in adolescence are scarce, which limits the scope of the proposed discussion.</p><p><strong>Conclusions: </strong>It cannot be argued that adolescents should have different abilities to refuse a treatment or procedure compared to those required to give consent. The importance of these skills seems to vary between these situations. This difference is justified by the need to consider potential harm to health, even though it could be argued that damage to health should be part of the bioethical deliberation surrounding the decision, rather than a factor in the assessment of decisional capacity.</p>","PeriodicalId":14867,"journal":{"name":"Jornal de pediatria","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2025-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144086304","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Effectiveness of pneumococcal conjugate 13-valent vaccine against severe pneumonia in Panama: a matched case-control study.","authors":"Jacqueline Levy, Rodrigo DeAntonio, Xavier Sáez-Llorens","doi":"10.1016/j.jped.2025.03.008","DOIUrl":"https://doi.org/10.1016/j.jped.2025.03.008","url":null,"abstract":"<p><strong>Objective: </strong>In Panama, the 13-valent pneumococcal conjugate vaccine (PCV13) was included in the primary immunization schedule in 2010 with a 3-dose schedule. The authors evaluated the effectiveness of PCV13 against severe community-acquired pneumonia in children of Panama after its introduction into the national immunization program.</p><p><strong>Methods: </strong>A retrospective matched case-control study was conducted at Hospital del Niño Doctor José Renán Esquivel, collecting data from children 2 to 59 months of age in years subsequent to the introduction of the PCV13 vaccine (2013-2015). Cases of severe community-acquired pneumonia had radiographically confirmed pneumonia (consolidated or with pleural effusion) or pneumonia with \"other infiltrate\" associated with CRP ≥ 40 mg/L with severity criteria according to the 2013 World Health Organization definition. Controls were children hospitalized for non-immune-preventable diseases matched by cases' age and admission date. Vaccine effectiveness was estimated as (1 - odds ratio) × 100 % with 95 % confidence intervals.</p><p><strong>Results: </strong>78 paired cases with 198 controls were included. In the cases, the mean age was 13.7 ± 10.3 SD months, and the hospital stay was 9.7 + 6.1 days. Overall, the effectiveness of PCV13 against severe community-acquired pneumonia was 54.0 % (95 % CI 25.0-72.0 %, p < 0.05). Vaccine effectiveness among children under 1 year was 61 % (95 % CI: 23.0-81.0 %) and 43 % (95 % CI:16.0-74.0 %) for children 1 to 4 years. For children who received at least 1 PCV13 dose was 17.2 % (95 % CI: 8.8-33.7 %). Overcrowding and lack of vaccination against influenza were risk factors for lower vaccine effectiveness.</p><p><strong>Conclusions: </strong>PCV13 was effective in preventing severe cases of community-acquired pneumonia in children in Panama.</p>","PeriodicalId":14867,"journal":{"name":"Jornal de pediatria","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2025-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143993432","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Prognosis and postoperative surveillance of benign ovarian tumors in children: a single-center retrospective study.","authors":"XiaoLi Chen, DuoTe Cai, Yi Chen, Weiwei Chen, YueBin Zhang, ZhiGang Gao, QingJiang Chen","doi":"10.1016/j.jped.2025.03.009","DOIUrl":"https://doi.org/10.1016/j.jped.2025.03.009","url":null,"abstract":"<p><strong>Objective: </strong>To evaluate the prognosis of benign ovarian tumors and develop a postoperative surveillance strategy for children based on the findings.</p><p><strong>Methods: </strong>The clinical data of children with benign ovarian tumors treated in the hospital from January 2014 to December 2021 were retrospectively analyzed.</p><p><strong>Results: </strong>A total of 404 patients were included in this study, with an average age of 9.1 ± 3.1 years. All patients underwent a total of 423 procedures, including 61 oophorectomy and 362 ovary-sparing surgeries. 67 patients were lost to follow-up after surgery. The remaining 337 patients were followed up for a period ranging from 3 months to 9 years (mean 1.6 ± 1.8 years). The ovarian preservation rate for patients undergoing ovary-sparing surgery for the first time was 94.4% (271/287). The overall recurrence rate of benign ovarian tumors was 3.9% (13/337). Of the 13 patients with recurrence, 10 had regular imaging examinations and did not develop symptoms. Three patients had irregular follow-up after surgery and returned to the hospital due to symptoms. The first recurrence interval of these 13 patients after surgery ranged from 0.6 to 5.3 years (mean 2.0 ± 1.4 years). 84.6% (11/13) of the recurrence cases developed within 3 years after surgery.</p><p><strong>Conclusion: </strong>Ovary-sparing surgery for benign ovarian tumors has a favorable prognosis and a high rate of ovarian preservation. Regular follow-up after surgery for benign ovarian tumors is necessary. Annual imaging follow-up for at least 3 years postoperative can detect most recurrence cases.</p>","PeriodicalId":14867,"journal":{"name":"Jornal de pediatria","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2025-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144016265","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Thatyana Ribeiro Medeiros, Camila Barros Melgaço da Silva, Flávia Nunes Benicio de Souza, Hannah Schmidel Kautsky, Luana Martins de Oliveira, Luana Martins de Toledo, Alan Araújo Vieira
{"title":"Comparison of electrical bioimpedance in newborns with electrodes positioned on the right and left sides of the body.","authors":"Thatyana Ribeiro Medeiros, Camila Barros Melgaço da Silva, Flávia Nunes Benicio de Souza, Hannah Schmidel Kautsky, Luana Martins de Oliveira, Luana Martins de Toledo, Alan Araújo Vieira","doi":"10.1016/j.jped.2025.03.007","DOIUrl":"https://doi.org/10.1016/j.jped.2025.03.007","url":null,"abstract":"<p><strong>Objective: </strong>Bioelectrical impedance analysis is a method used to assess body composition; a noninvasive test performed using an easy-to-handle portable device used in clinical practice. However, nonstandard methods in neonates hinder external validation and reliability. Currently, bioimpedance analysis is performed in newborns with electrodes positioned on the right side of the body; however, the use of medical devices, including vascular access, can prevent its use.</p><p><strong>Methods: </strong>An uncontrolled before-after clinical trial comparing resistance and reactance measurements by bioelectrical impedance analysis on both sides was conducted. Measurements were performed immediately after the randomization of the initial measurement side. The sample size was calculated by considering a 10% deviation from the mean resistance and reactance values of previous studies with alpha and beta errors of 10% and 20%, respectively. Binary linear regression was used to quantify the correlation.</p><p><strong>Results: </strong>A significant difference was observed between resistance (672.88 ± 136.30 vs. 649.22 ± 119.59) and reactance (46.34 ± 17.99 vs. 44.439 ± 19.42) values measured on the right and left sides, respectively. However, when measured on both sides of the body, resistance and reactance values showed a good correlation (0.98 for both models, p < 0.001). Positioning the electrodes on the left side significantly affected the resistance and reactance values measured by bioelectrical impedance analysis compared with those on the right side.</p><p><strong>Conclusion: </strong>Electrodes positioned on opposite sides of the body generated different resistance and reactance values, implying the need to use the right side exclusively for standard positioning. This restriction can create difficulties for the routine use of this technique in newborns.</p>","PeriodicalId":14867,"journal":{"name":"Jornal de pediatria","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2025-04-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144019544","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Kallianna Paula Duarte Gameleira, Juliana de Vasconcellos Thomas, Vitor Guilherme Brito de Araújo, Cláudia Vicari Bolognani, Sérgio Eduardo Soares Fernandes, Fábio Ferreira Amorim
{"title":"Cutoff levels for newborn screening of 21-OH deficiency in a Brazilian metropolitan area.","authors":"Kallianna Paula Duarte Gameleira, Juliana de Vasconcellos Thomas, Vitor Guilherme Brito de Araújo, Cláudia Vicari Bolognani, Sérgio Eduardo Soares Fernandes, Fábio Ferreira Amorim","doi":"10.1016/j.jped.2025.03.003","DOIUrl":"10.1016/j.jped.2025.03.003","url":null,"abstract":"<p><strong>Objective: </strong>To evaluate the accuracy of neonatal 17-hydroxyprogesterone (N17OHP) levels adjusted for birth weight (BW) and time of the sample collection (TC) and propose optimized cutoff values to improve the effectiveness of newborn screening tests for congenital adrenal hyperplasia (CAHNBS) programs, utilizing a comprehensive dataset encompassing all newborn screening tests for 21-hydroxylase deficiency (21OHD) conducted over a decade in a Brazilian metropolitan region.</p><p><strong>Methods: </strong>A cross-sectional study analyzed all CAHNBS tests from newborns aged 2 to 7 days in the Federal District, Brazil, from January 2012 to September 2022. The accuracy of cutoff values based on the 99.5th percentile (99.5P) for BW and TC was compared to the CAHNBS program of São Paulo and a threshold of ≥20 mg/dL. New cutoff values were proposed to enhance screening effectiveness.</p><p><strong>Results: </strong>Among the 340,291 newborns screened, CAH-21OHD was confirmed in 11 cases. The N17OHP cutoff in this sample reduced false positives for neonates ≤ 2500 g but increased them for those > 2500 g The proposed cutoff values based on 99.5P from the sample for neonates ≤ 2500 g, combined with a fixed cutoff ≥ 20 mg/dL for those > 2500 g, showed superior specificity (99.83 %, 95 % CI: 99.81-99.84 %), LR+ (579.16, 95 % CI: 524.23-627.87), PPV (1.84, 95 %CI: 1.70-1.99), and accuracy (99.83 %, 95 %CI: 99.81-99.84 %) than prior criteria.</p><p><strong>Conclusion: </strong>The proposed 17OHP cutoff strategy effectively reduced false positives, improving specificity, LR+, PPV, and accuracy Thus, it optimized CAHNBS programs while minimizing unnecessary costs and parental distress.</p>","PeriodicalId":14867,"journal":{"name":"Jornal de pediatria","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2025-04-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143780157","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Jeferson de Sousa Justino, Francisco Plácido Nogueira Arcanjo, Luiz Odorico Monteiro de Andrade, Ivana Cristina de Holanda Cunha Barreto, Lizandro de Andrade Teles, Ana Talita Vasconcelos Arcanjo, Edcley Sousa Teixeira, Marya Clara Barros Mororó
{"title":"Effects of hydrotherapy and Hammock positioning on weight gain in low-birth-weight premature newborns: a randomized clinical trial.","authors":"Jeferson de Sousa Justino, Francisco Plácido Nogueira Arcanjo, Luiz Odorico Monteiro de Andrade, Ivana Cristina de Holanda Cunha Barreto, Lizandro de Andrade Teles, Ana Talita Vasconcelos Arcanjo, Edcley Sousa Teixeira, Marya Clara Barros Mororó","doi":"10.1016/j.jped.2025.03.005","DOIUrl":"https://doi.org/10.1016/j.jped.2025.03.005","url":null,"abstract":"<p><strong>Objective: </strong>To evaluate and compare whether hydrotherapy and hammock positioning techniques assist in the weight gain of premature newborns.</p><p><strong>Methodology: </strong>A single-blind randomized clinical trial was conducted at Santa Casa de Misericórdia Hospital in Sobral, between July 2022 and October 2023. The trial included 16 months of data collection and involved seventy-six premature newborns with low birth weight, of which only sixty were included after meeting the inclusion criteria. These newborns were randomly divided into four groups: one control group and three groups that received different intervention techniques (hydrotherapy, hammock positioning, and a combined group of hydrotherapy and hammock positioning). The newborns were monitored for clinical stability and specific signs before and after the interventions. The techniques were applied daily for 15 days.</p><p><strong>Results: </strong>During the 15-day follow-up, the control group had a mean weight gain of 305 g. The group that received hydrotherapy gained 346 g, but without significance. The hammock group and the combined hydrotherapy and hammock group showed significant weight gains: the hammock group had an increase of 360 g (p = 0.011), while the combined group achieved a gain of 616 g (p = 0.0001). Significant increases in arm circumferences were observed in the hammock group and the hydrotherapy combined with the hammock positioning group.</p><p><strong>Conclusion: </strong>The results indicate that the combination of hydrotherapy and hammock positioning leads to a significant increase in weight gain in premature newborns. The isolated use of hammock positioning also showed positive effects, but the isolated use of hydrotherapy did not yield significant results (Brazilian Registry of Clinical Trials RBR-6 g5f4jz).</p>","PeriodicalId":14867,"journal":{"name":"Jornal de pediatria","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2025-04-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143998275","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Luís Fernando Ferreira Cavalcante, Giovanna Costa, Sophia Massafelli Battistuta, Pedro Faria Makabe, Isadora Silva Fanucci Bueno, Bruno Yuamoto, Felipe Endrigo Gonçalves Vilela, Marco Aurélio Palazzi Sáfadi
{"title":"Surgical management for periodic fever, aphthous stomatitis, pharyngitis and cervical adenitis (PFAPA) syndrome: a systematic review and meta-analysis.","authors":"Luís Fernando Ferreira Cavalcante, Giovanna Costa, Sophia Massafelli Battistuta, Pedro Faria Makabe, Isadora Silva Fanucci Bueno, Bruno Yuamoto, Felipe Endrigo Gonçalves Vilela, Marco Aurélio Palazzi Sáfadi","doi":"10.1016/j.jped.2025.03.006","DOIUrl":"https://doi.org/10.1016/j.jped.2025.03.006","url":null,"abstract":"<p><strong>Objective: </strong>This systematic review and meta-analysis aimed to evaluate the efficacy of surgical management, specifically total and partial tonsillectomy, for Periodic Fever, Aphthous Stomatitis, Pharyngitis, and Cervical Adenitis (PFAPA) syndrome, focusing on symptom resolution and recurrence reduction.</p><p><strong>Data sources: </strong>A systematic search of MEDLINE, Scopus, and Cochrane databases identified randomized controlled trials (RCTs) comparing surgical to non-surgical management in children with PFAPA. Data extraction and quality assessment adhered to Cochrane guidelines and PRISMA protocols. Risk ratios (RR) and confidence intervals (CI) were calculated using random-effects models.</p><p><strong>Summary of findings: </strong>After the removal of duplicates, 31 studies were screened and 3 studies were included. Pooled analysis revealed a 72% reduction in persistent symptoms following surgical interventions compared to non-surgical management (RR: 0.28, 95% CI: 0.12-0.68, I² = 22%, p = 0.005).</p><p><strong>Conclusion: </strong>The findings confirm that surgical management, including total and partial tonsillectomy, is an effective therapeutic option for PFAPA, with substantial benefits in symptom resolution and quality of life improvement. While surgery offers long-term benefits, its risks, and broader immunological implications require careful consideration. The study underscores the necessity for larger, multicenter trials to validate these findings across diverse populations and optimize treatment strategies.</p>","PeriodicalId":14867,"journal":{"name":"Jornal de pediatria","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2025-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144019549","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Nayara Maria Furquim Nasser, Antonio Carlos Pastorino, Thais Costa Lima de Moura, Beni Morgenstern, Mayra de Barros Dorna, Ana Paula Beltran Moschione Castro
{"title":"Understanding the natural history of selective IgA deficiency.","authors":"Nayara Maria Furquim Nasser, Antonio Carlos Pastorino, Thais Costa Lima de Moura, Beni Morgenstern, Mayra de Barros Dorna, Ana Paula Beltran Moschione Castro","doi":"10.1016/j.jped.2025.03.002","DOIUrl":"10.1016/j.jped.2025.03.002","url":null,"abstract":"<p><strong>Objective: </strong>Patients with selective IgA deficiency (SIgAD) present elevated morbidity associated with infections, allergic conditions, autoimmune disorders, and neoplasms. This study aims to characterize clinical manifestations, disease progression, and laboratory findings in a cohort of pediatric patients with SIgAD.</p><p><strong>Methods: </strong>The study included patients with confirmed SIgAD and a clinical history of at least 5 years. Data encompassed clinical manifestations of the disease, patient outcomes, and laboratory findings, including IgA, IgG, IgM, IgE levels and complete blood count.</p><p><strong>Results: </strong>A total of 51 patients (1.2:1 female-to-male ratio) were included, with a median age at diagnosis of 6 years. Infections were the most common clinical manifestations of SIgAD (98 %), with pneumonia being the most frequent (94 %), followed by sinusitis (70 %). Additionally, 47 patients (92.1 %) exhibited allergic manifestations, including rhinitis or asthma. Autoimmune conditions were identified in 10 patients, predominantly thyroiditis (60 %), while neoplasms were observed in 3 patients. The sequence of disease onset revealed a natural progression, beginning with infectious diseases, followed significantly by allergic and autoimmune conditions. Elevated immunoglobulin levels (IgM or IgG) were observed in 25 patients, with hypergammaglobulinemia significantly associated with autoimmune conditions or the presence of autoantibodies (p < 0.05).</p><p><strong>Conclusions: </strong>SIgAD is a clinically significant condition. Understanding its natural history deepens our knowledge of the disease and helps early detection and diagnosis of comorbidities that may arise at various stages of a patient's life. Monitoring other immunoglobulin levels may offer potential biomarkers for predicting autoimmune conditions; however, larger studies are needed to validate these biomarkers.</p>","PeriodicalId":14867,"journal":{"name":"Jornal de pediatria","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2025-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143764056","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Jessica Santos Passos Costa, Heli Vieira Brandão, Camilla da Cruz Martins, Raquel Guimarães Benevides, Jean Carlos Zambrano Contreras, Luiz Gustavo Sparvoli, Pedro Augusto Ramos Vanzele, Carla Romano Taddei, Tatiana de Oliveira Vieira, Graciete Oliveira Vieira
{"title":"Intestinal microbiota development in the first week of life of preterm newborns.","authors":"Jessica Santos Passos Costa, Heli Vieira Brandão, Camilla da Cruz Martins, Raquel Guimarães Benevides, Jean Carlos Zambrano Contreras, Luiz Gustavo Sparvoli, Pedro Augusto Ramos Vanzele, Carla Romano Taddei, Tatiana de Oliveira Vieira, Graciete Oliveira Vieira","doi":"10.1016/j.jped.2025.02.003","DOIUrl":"10.1016/j.jped.2025.02.003","url":null,"abstract":"<p><strong>Objective: </strong>This study aimed to evaluate the intestinal microbiota development in the first week of life of preterm newborns (PTNB) treated at a public hospital in a municipality in the Brazilian Northeast.</p><p><strong>Methods: </strong>This is an observational, longitudinal, and descriptive study with 23 PTNBs. Two stool samples were collected from each neonate (fasting/meconium and seventh day of life) for stool microbiota analysis by 16S rRNA gene sequencing. The authors analyzed alpha diversity (Chao1, Shannon, and Simpson indices) and principal coordinates of beta diversity.</p><p><strong>Results: </strong>Forty-six stool samples from 23 PTNBs were analyzed at the taxonomic level. Microbiota's development was dynamic with low diversity. The authors observed a statistical association with the genera Enterobacterales, Streptococcus, Bacteroides, Clostridium_sensu_stricto_1, Enterococcus, and Bifidobacterium in the fasting samples when compared to the day-7 samples. The genus Staphylococcus also dominated at both times.</p><p><strong>Conclusion: </strong>Dynamics were observed in the intestinal microbiota development, with an alpha diversity decrease in the stool samples collected at fasting/meconium and on the seventh day of life.</p>","PeriodicalId":14867,"journal":{"name":"Jornal de pediatria","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2025-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143753037","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Maria Gabriella Adeodato Prado, Francisco Placido Nogueira Arcanjo, Luiz Odorico Monteiro de Andrade, Ivana Cristina de Holanda Cunha Barreto, Lizandro de Andrade Teles, Jeferson de Sousa Justino, Edcley de Souza Teixeira, Marya Clara Barros Mororó
{"title":"Use of web and mobile device technologies in the management of childhood asthma: a systematic review and meta-analysis.","authors":"Maria Gabriella Adeodato Prado, Francisco Placido Nogueira Arcanjo, Luiz Odorico Monteiro de Andrade, Ivana Cristina de Holanda Cunha Barreto, Lizandro de Andrade Teles, Jeferson de Sousa Justino, Edcley de Souza Teixeira, Marya Clara Barros Mororó","doi":"10.1016/j.jped.2025.01.013","DOIUrl":"10.1016/j.jped.2025.01.013","url":null,"abstract":"<p><strong>Objective: </strong>The objective of this review is to assess the use of support tools for children with asthma, based on web and mobile device technologies, and their impact on asthma control.</p><p><strong>Method: </strong>This is a systematic review conducted in accordance with the PRISMA guidelines and the Joanna Briggs Institute (JBI) Manual. The research question defined by the PICO strategy was: ''What are the effects of web-based and mobile device support tools on asthma control in children?'' The search was conducted in the Medline (via PubMed), SciELO, and Embase databases between October and December 2023, with completion in July 2024.</p><p><strong>Results: </strong>The systematic review analyzed 388 articles and selected 4 studies on technologies for managing asthma in children. The studies showed that mobile apps and electronic monitoring improve asthma control, treatment adherence, and caregivers' quality of life. The meta-analysis showed a mean increase in Asthma Control Test (ACT) scores of 2.73 (95 % CI: 1.95, 3.51) with P < 0.0001, indicating a significant improvement in asthma control scores, highlighting the effectiveness of these technologies.</p><p><strong>Conclusions: </strong>This study demonstrates that digital tools, such as web technologies and mobile devices, can significantly improve the management of childhood asthma, as reflected by an increase in Asthma Control Test (ACT) scores. Despite limitations, the findings are promising. Future research is needed to strengthen the evidence and guide clinical practice in pediatric asthma management.</p>","PeriodicalId":14867,"journal":{"name":"Jornal de pediatria","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2025-04-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143780105","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}