Jornal de pediatria最新文献

A study on neurodevelopmental outcomes in infants with congenital hypothyroidism highlights the importance of periodic developmental assessment.

IF 2.8 4区医学

Jornal de pediatria Pub Date : 2025-02-06 DOI: 10.1016/j.jped.2025.01.001

A S van Trotsenburg, N Zwaveling-Soonawala

引用次数: 0

Are inborn errors of immunity being investigated in the pediatric intensive care unit?

IF 2.8 4区医学

Jornal de pediatria Pub Date : 2025-02-05 DOI: 10.1016/j.jped.2024.12.006

Cecília Coelho Moraes de Brito, Patrícia Gomes de Matos Bezerra, Paula Teixeira Lyra, Maria Júlia Gonçalves de Mello

{"title":"Are inborn errors of immunity being investigated in the pediatric intensive care unit?","authors":"Cecília Coelho Moraes de Brito, Patrícia Gomes de Matos Bezerra, Paula Teixeira Lyra, Maria Júlia Gonçalves de Mello","doi":"10.1016/j.jped.2024.12.006","DOIUrl":"https://doi.org/10.1016/j.jped.2024.12.006","url":null,"abstract":"Objectives: To assess the frequency of diagnostic investigation for inborn errors of immunity (IEI) in the presence of warning signs and clinical outcomes of children hospitalized in the pediatric intensive care unit (PICU) according to age group.Material and methods: This retrospective cross-sectional study included children hospitalized in the PICU of a referral hospital over two years. Warning signs were collected according to age group (up to and over one year), and sociodemographic and clinical variables, basic investigation of IEI, follow-up by the immunology service, and hospital discharge and death were also assessed.Results: Of 680 included children, 330 (48.5%) were aged up to one year, and 350 (51.5%) were over one year. Among those aged up to one year, 108 (32.7%) had two or more warning signs, and only 22 (20.4%) were investigated for IEI. Considering the group aged over one year, 48 (13.7%) had two or more warning signs, and 21 (43.8%) were investigated for IEI. The highest number of deaths occurred among children aged up to one year with two or more warning signs (58.8%).Conclusions: Few children with warning signs were investigated for IEI, representing missed opportunities to timely diagnose IEI, which may impact the risk of death.","PeriodicalId":14867,"journal":{"name":"Jornal de pediatria","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2025-02-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143373930","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Worldwide prevalence of the double burden of malnutrition in children and adolescents at the individual level: systematic review and meta-regression. 全球儿童和青少年营养不良双重负担在个人层面的普遍性：系统回顾和元回归。

IF 2.8 4区医学

Jornal de pediatria Pub Date : 2025-01-31 DOI: 10.1016/j.jped.2024.11.010

Raytta Silva Viana, Keisyanne De Araújo-Moura, Augusto César Ferreira De Moraes

{"title":"Worldwide prevalence of the double burden of malnutrition in children and adolescents at the individual level: systematic review and meta-regression.","authors":"Raytta Silva Viana, Keisyanne De Araújo-Moura, Augusto César Ferreira De Moraes","doi":"10.1016/j.jped.2024.11.010","DOIUrl":"10.1016/j.jped.2024.11.010","url":null,"abstract":"Objective: This study aimed to assess the prevalence of the double burden of malnutrition (DBM) at the individual level in children and adolescents through a comprehensive literature review.Sources: Electronic databases, including PubMed, Scopus, and Web of Science, were searched for articles published up until September 9, 2022. Studies reporting individual-level DBM in children and adolescents were included, and meta-regression models were used to investigate potential causes of heterogeneity across studies.Summary of the findings: Of the 784 articles initially retrieved, 11 met the inclusion criteria. The overweight/obesity prevalence ranges from 8.1 % to 37.0 %, and the undernutrition (stunting, micronutrient deficiency, or anemia) from 4.2 % and 73.0 %. The prevalence of DBM ranged from 1 % to 35.4 %, with the highest rates observed in low- and middle-income countries. Among children, Asia reported the highest DBM prevalence, while in adolescents, Latin America had the highest rates. The review revealed significant variability in DBM prevalence across studies, with a notable increase in research on this topic over the past decade (2013-2022).Conclusion: These findings underscore the concerning global prevalence of the double burden of malnutrition in children and adolescents, particularly in low- and middle-income countries. Standardized definitions and methods are urgently needed to improve comparability, along with further research to identify the specific drivers of DBM and inform effective prevention strategies. CRD42022333424.","PeriodicalId":14867,"journal":{"name":"Jornal de pediatria","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2025-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142927151","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Renal scarring in children with febrile urinary tract infection.

IF 2.8 4区医学

Jornal de pediatria Pub Date : 2025-01-31 DOI: 10.1016/j.jped.2024.10.011

Arife Uslu Gökceoğlu, Nesrin Taş

{"title":"Renal scarring in children with febrile urinary tract infection.","authors":"Arife Uslu Gökceoğlu, Nesrin Taş","doi":"10.1016/j.jped.2024.10.011","DOIUrl":"https://doi.org/10.1016/j.jped.2024.10.011","url":null,"abstract":"Objective: The authors aim to evaluate characteristics of children with fUTI and results of renal bladder ultrasonography (RBUS) and late dimercaptosuccinicacid (DMSA) scan.Methods: This study is designed as retrospective analysis of RBUS and DMSA reports of children with fUTI. Age, gender, number of fUTI, presence of constipation and vesicouretheral reflux (VUR) were recorded.Results: The study included 160 children with fUTI with a median age of 7 years (6 months 18 years old). The majority of children in this study were girls (86.3 %), older than 60 months (73.1 %) and had one episode of fUTI. The recurrence rates of UTI were similar in both girls and boys. The total rate of constipation was 21.9 %. The rate of renal scarring on DMSA was 16.9 %. The rates of renal scarring were similar at three age groups and both genders. The rate of renal scarring was higher in children with recurrent UTI compared to those with one episode of fUTI (26.4 % and 12.5 %, respectively; p = 0.04). The rate of constipation in children with renal scarring and normal DMSA was similar (p = 0.07). The rate of trabeculation and thick bladder wall was higher in children with renal scarring at DMSA than children with no renal scarring (p = 0.03).Conclusion: The present study demonstrated that 16.9 % of children with fUTI had renal scarring. The rates of renal scarring were similar in both gender and age groups. Children with recurrent UTI and abnormal bladder results at RBUS had higher rates of renal scarring.","PeriodicalId":14867,"journal":{"name":"Jornal de pediatria","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2025-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143074468","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Impact of climate change and air pollution on childhood respiratory health. 气候变化和空气污染对儿童呼吸道健康的影响。

IF 2.8 4区医学

Jornal de pediatria Pub Date : 2025-01-31 DOI: 10.1016/j.jped.2024.11.007

Marilyn Urrutia-Pereira, Dirceu Solé

引用次数: 0

Linking common mental disorders and asthma in Brazilian adolescents: a cross-sectional analysis of the ERICA study.

IF 2.8 4区医学

Jornal de pediatria Pub Date : 2025-01-31 DOI: 10.1016/j.jped.2025.01.003

Mara Morelo Rocha Felix, Fábio Chigres Kuschnir, Érica Azevedo de Oliveira Costa Jordão, Bernardo Rangel Tura, Dirceu Solé, Maria Cristina Caetano Kuschnir

{"title":"Linking common mental disorders and asthma in Brazilian adolescents: a cross-sectional analysis of the ERICA study.","authors":"Mara Morelo Rocha Felix, Fábio Chigres Kuschnir, Érica Azevedo de Oliveira Costa Jordão, Bernardo Rangel Tura, Dirceu Solé, Maria Cristina Caetano Kuschnir","doi":"10.1016/j.jped.2025.01.003","DOIUrl":"https://doi.org/10.1016/j.jped.2025.01.003","url":null,"abstract":"Objective: Asthma is a heterogeneous chronic disease of the airways, affecting all age groups, especially children and adolescents. The aim of this study was to evaluate several factors associated with asthma in Brazilian adolescents.Methods: Cross-sectional study of a national representative sample of school-based adolescents aged 12-17 years from The Study of Cardiovascular Risk in Adolescents (ERICA) stratified by region and conglomerate by schools. The authors studied the following variables: sociodemographic characteristics, lifestyle, smoking, eating habits, sleeping and mental conditions.Results: Data from 66,567 adolescents were analyzed, 50.2 % of whom were female. Of the total, 52.7 % were between 12 and 14 years old. The overall prevalence of asthma was 14.5 % (95 %CI: 13.6-15.5). Asthma was associated with female sex (PR 1.35; 95 %CI: 1.15-1.57), white skin color (PR 1.25; 95 %CI: 1.04-1.50), private school (PR 1.26; 95 %CI: 1.05-1.52), smoking (PR 1.93; 95 %CI: 1.54-2.38); and alcohol consumption (PR 1.74; 95 %CI: 1.52-2.03). Excessive screen time (PR 1.19; 95 %CI 1.01-1.42) and short sleep duration (PR 1.28; 95 %CI 1.05-1.57) were also associated. Healthy eating habits, such as adolescents who ate breakfast, drank water, and ate meals with their parents, were associated with a lower prevalence of asthma. In relation to comorbidities, asthma was associated with common mental disorders (CMD) (PR 1.94; 95 %CI 1.64-2.27; p < 0,00,001), but not with overweight or obesity (PR 1.09; 95 %CI 0.87-1.38). In the correspondence analysis, CMD was the strongest factor associated with asthma.Conclusion: Asthma was associated with several determinants in Brazilian adolescents, but the association with CMD deserves special attention in this age group.","PeriodicalId":14867,"journal":{"name":"Jornal de pediatria","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2025-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143122839","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Evaluation of acquisition and retention of non-technical skills of residents submitted to interprofessional simulation-based training in pediatric cardiopulmonary resuscitation.

IF 2.8 4区医学

Jornal de pediatria Pub Date : 2025-01-30 DOI: 10.1016/j.jped.2024.12.003

Rafaella Fadel Friedlaender, Eduardo Maranhão Gubert, Cláudia Maria Baroni Fernandes, Rosiane Guetter Mello, Izabel Cristina Meister Martins Coelho

{"title":"Evaluation of acquisition and retention of non-technical skills of residents submitted to interprofessional simulation-based training in pediatric cardiopulmonary resuscitation.","authors":"Rafaella Fadel Friedlaender, Eduardo Maranhão Gubert, Cláudia Maria Baroni Fernandes, Rosiane Guetter Mello, Izabel Cristina Meister Martins Coelho","doi":"10.1016/j.jped.2024.12.003","DOIUrl":"https://doi.org/10.1016/j.jped.2024.12.003","url":null,"abstract":"Objective: The purpose of the study was to evaluate the acquisition and retention of non-technical skills by pediatric residents who participated in an interprofessional simulated pediatric cardiopulmonary resuscitation scenario through simulation-based training.Method: This prospective cohort study was conducted at a simulation center of a Pediatric Hospital. Ninety-six residents of pediatrics and nursing were divided into 16 interprofessional teams and participated in a cardiopulmonary resuscitation simulated scenario followed by a debriefing session. It was conducted twice on the same day and repeated after a period of time that ranged from 107 to 161 days. Groups were evaluated for the acquisition and retention of non-technical skills and global non-technical performance through a valid and reliable tool for measuring teamwork in medical emergencies.Results: Participants demonstrated an improvement in leadership, teamwork, task management, and overall performance of the team after the first intervention. However, when evaluated during the second intervention, retention of leadership and teamwork were noted, but not for task management and overall performance.Conclusion: Learning non-technical skills is complex and requires training, ideally with short periodicity, since it demands frequent practice for its acquisition and retention. The present research showed that non-technical skills can be acquired through simulation-based training. However, it was noted that the retention of these skills is more complex, requiring repeated simulations over a longer period of time. Therefore, further research on the learning curve, time to acquisition, and retention of non-technical skills trained with simulation-based education is warranted.","PeriodicalId":14867,"journal":{"name":"Jornal de pediatria","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2025-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143080023","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Case-control study on long-term kidney outcomes in very low birth weight infants: impact of growth restriction and maternal preeclampsia.

IF 2.8 4区医学

Jornal de pediatria Pub Date : 2025-01-25 DOI: 10.1016/j.jped.2025.01.002

Laís Fagundes Pasini, Breno Fauth de Araújo, Lucas Girotto de Aguiar, Luciano da Silva Selistre, Vandréa Carla de Souza

{"title":"Case-control study on long-term kidney outcomes in very low birth weight infants: impact of growth restriction and maternal preeclampsia.","authors":"Laís Fagundes Pasini, Breno Fauth de Araújo, Lucas Girotto de Aguiar, Luciano da Silva Selistre, Vandréa Carla de Souza","doi":"10.1016/j.jped.2025.01.002","DOIUrl":"https://doi.org/10.1016/j.jped.2025.01.002","url":null,"abstract":"Objective: To identify factors, particularly neonatal acute kidney injury, associated with an increased risk of developing chronic kidney disease (CKD) within the first 10 years of life in children with a history of prematurity and very low birth weight (VLBW).Methods: This nested case-control study was conducted on VLBW infants (> 500 g and < 1.500 g) born between 2012 and 2022. The population (n = 119) included children who developed CKD (n = 55) and controls with normal findings (n = 64). CKD was defined by abnormal blood pressure, reduced glomerular filtration rate, or elevated urinary albumin excretion. Data on neonatal and maternal factors were analyzed using logistic regression to identify predictors of CKD.Results: Of the 267 eligible children 119 were included, with a median age of 32 months, and median gestational age and birth weight of 30 weeks and 1170 g, respectively. Children with CKD had lower birth weight Z-scores (-1.06 vs. -0.89), a higher occurrence of extrauterine growth restriction (EUGR) (72 % vs. 51 %), and an increased likelihood of maternal preeclampsia exposure. Maternal preeclampsia was identified as an independent predictor of CKD, associated with a 5 % increase in the odds of developing the condition (OR 1.05, 95 % CI 1.01-1.66).Conclusion: Maternal preeclampsia was associated with CKD in children with a history of VLBW. This finding highlights the importance of long-term follow-up and early identification of at-risk individuals.","PeriodicalId":14867,"journal":{"name":"Jornal de pediatria","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2025-01-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143059118","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Predicting postoperative adhesive small bowel obstruction in infants under 3 months with intestinal malrotation: a random forest approach.

IF 2.8 4区医学

Jornal de pediatria Pub Date : 2025-01-21 DOI: 10.1016/j.jped.2024.11.011

Pengfei Chen, Haiyi Xiong, Jian Cao, Mengying Cui, Jinfeng Hou, Zhenhua Guo

{"title":"Predicting postoperative adhesive small bowel obstruction in infants under 3 months with intestinal malrotation: a random forest approach.","authors":"Pengfei Chen, Haiyi Xiong, Jian Cao, Mengying Cui, Jinfeng Hou, Zhenhua Guo","doi":"10.1016/j.jped.2024.11.011","DOIUrl":"https://doi.org/10.1016/j.jped.2024.11.011","url":null,"abstract":"Objective: This study aimed to develop a predictive model using a random forest algorithm to determine the likelihood of postoperative adhesive small bowel obstruction (ASBO) in infants under 3 months with intestinal malrotation.Methods: A machine learning model was used to predict postoperative adhesive small bowel obstruction using comprehensive clinical data extracted from 107 patients with a follow-up of at least 24 months. The Boruta algorithm was used for selecting clinical features, and nested cross-validation tuned and selected hyper-parameters for the random forest model. The model's performance was validated with 1000 bootstrap samples and assessed using receiver operating characteristic (ROC) analysis, the area under the ROC curve (AUC), sensitivity, specificity, precision, and F1 score.Results: The random forest model demonstrated high diagnostic accuracy with an AUC of 0.960. Significant predictors of ASBO included pre-operative white blood cell count (pre-WBC), mechanical ventilation (MV) duration, surgery duration, and post-operative albumin levels (post-ALB). Partial dependence plots showed non-linear relationships and threshold effects for these variables. The model achieved high sensitivity (0.805) and specificity (0.952), along with excellent precision (0.809) and a robust F1 score (0.799), indicating balanced recall and precision performance.Conclusion: This study presents a machine learning model to accurately predict postoperative ASBO in infants with intestinal malrotation. Demonstrating high accuracy and robustness, this model shows great promise for enhancing clinical decision-making and patient outcomes in pediatric surgery.","PeriodicalId":14867,"journal":{"name":"Jornal de pediatria","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2025-01-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143023439","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Impact of non-weight-dependent low-dose somatropin on bone accrual in childhood-onset GH deficient in the transition: an 18-month randomized controlled trial. 非体重依赖性低剂量生长激素对儿童期生长激素缺乏症患者骨质增生的影响：一项为期18个月的随机对照试验。

IF 2.8 4区医学

Jornal de pediatria Pub Date : 2025-01-02 DOI: 10.1016/j.jped.2024.10.010

Valesca Mansur Kuba, Antonia B S Castro, Cláudio Leone, Durval Damiani

{"title":"Impact of non-weight-dependent low-dose somatropin on bone accrual in childhood-onset GH deficient in the transition: an 18-month randomized controlled trial.","authors":"Valesca Mansur Kuba, Antonia B S Castro, Cláudio Leone, Durval Damiani","doi":"10.1016/j.jped.2024.10.010","DOIUrl":"10.1016/j.jped.2024.10.010","url":null,"abstract":"Objective: Discontinuation of growth hormone therapy (rhGH) upon completion of linear growth may adversely affect bone mineral density and content (BMD/BMC) in adolescents with childhood-onset GH deficiency (CO-GHD) and predisposition to osteoporosis. Although the benefits of weight-dependent somatropin high doses over bone gain are established, little is known about fixed low doses. We analyzed the impact of non-weight-based low-dose somatropin on bone accrual during the transition among CO-DGH patients, treated since childhood.Methods: Lumbar spine (LS) and whole-body (WB) BMD and BMC were measured at baseline and after 18 months in 54 adolescents (age: 16.8 ± 1.6 years). They were retested and reclassified as GH sufficient (GHS, n = 28) and GH insufficient. The last group was later randomized to use rhGH (GH on; n = 15) or no treatment (GH off, n = 11) in this single-center open-label study. The average dose of rhGH was 0.5 ± 0.18 mg/day.Results: When comparing the groups, the GH off group had a lower percentage change in LS BMD than the GHS (0.53 % ± 5.9 vs. 4.42 % ± 4.1, respectively, p < 0.04). However, in the analysis of the GH on and off subgroups, the LS BMC percentage change was higher in the GH on (11.02 % ± 10.12 vs. 2.05 % ± 10.31, respectively, p < 0.04).Conclusion: Non-weight-based low-dose somatropin withdrawal for 18 months limits bone accrual in LS of CO-DGH subjects in transition, predisposing them to osteoporosis in adult life.","PeriodicalId":14867,"journal":{"name":"Jornal de pediatria","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2025-01-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142872144","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0