Jornal de pediatriaPub Date : 2026-05-01Epub Date: 2026-04-27DOI: 10.1016/j.jped.2026.101550
Daniele De Luca
{"title":"Quantitative lung ultrasound to understand pathophysiology and guide surfactant therapy in neonates with meconium aspiration","authors":"Daniele De Luca","doi":"10.1016/j.jped.2026.101550","DOIUrl":"10.1016/j.jped.2026.101550","url":null,"abstract":"","PeriodicalId":14867,"journal":{"name":"Jornal de pediatria","volume":"102 3","pages":"Article 101550"},"PeriodicalIF":2.5,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147772103","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Development of a childhood food and nutrition security observatory: experience of an interinstitutional initiative in the state of São Paulo","authors":"Karina Viani , Marcos Sakurada , Aracelia Costa , Mauro Fisberg , Priscila Maximino , Raul Cutait","doi":"10.1016/j.jped.2026.101547","DOIUrl":"10.1016/j.jped.2026.101547","url":null,"abstract":"<div><h3>Objective</h3><div>To describe the development of the FIESP Observatory for Childhood Food and Nutrition Security (FNS), a digital platform designed to organize and integrate public data on children aged 0 to 10 years in the state of São Paulo, Brazil.</div></div><div><h3>Methods</h3><div>This descriptive study involved three main stages: (1) a literature review and mapping of national and international observatories on health, nutrition, and childhood to identify best practices and gaps; (2) establishment of an expert committee of professionals in nutrition, public health, and public policies to guide indicator selection and ensure technical quality; and (3) technical development of the platform, including automated data extraction, processing, and integration into thematic dashboards. Public databases from official sources were incorporated, structured across six thematic axes: demographic, socioeconomic, FNS policies, nutritional, health, and educational profiles.</div></div><div><h3>Results</h3><div>The observatory was launched in May 2025 and made freely available online. It features six interactive panels and a “Your City” dashboard that consolidates key indicators for each municipality in São Paulo. Since its launch, it has received >9600 visits, with 4755 active users. The tool enables segmented analyses by geography, time, and demographics, providing evidence to support policy design and monitoring.</div></div><div><h3>Conclusions</h3><div>The Observatory represents an innovative and scalable model for consolidating childhood FNS data. By offering free, intuitive, and continuously updated access to official indicators, it supports policymakers, researchers, and civil society in addressing childhood food insecurity and advancing the right to adequate and healthy food.</div></div>","PeriodicalId":14867,"journal":{"name":"Jornal de pediatria","volume":"102 3","pages":"Article 101547"},"PeriodicalIF":2.5,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147673573","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Unveiling autism spectrum disorder for the pediatrician","authors":"Marcio Moacyr Vasconcelos , Luciana Gonçalves Azevedo Vasconcelos , Adriana Rocha Brito","doi":"10.1016/j.jped.2025.101458","DOIUrl":"10.1016/j.jped.2025.101458","url":null,"abstract":"<div><h3>Objectives</h3><div>To review the state of the art in autism spectrum disorder (ASD), including its etiologic puzzle, clinical features, pathophysiologic mechanisms, differential diagnosis, and therapeutic management.</div></div><div><h3>Data sources</h3><div>A search for papers published over the past 10 years in the databases PubMed-MEDLINE, Cochrane Library, and SCIELO was performed using the following terms: “autism” and “clinical features”, “differential diagnosis”, “pathophysiology”, or “management”. The search yielded 3240, 590, 6904, and 5023 papers, respectively. A total of 120 most relevant papers were selected based on their title and abstract content.</div></div><div><h3>Data synthesis</h3><div>The current prevalence of ASD is 1 in every 31 eight-year-old children. A genetic defect is found in 10–20% of individuals with ASD. Environmental risk factors that increase the likelihood of ASD include advanced parental age and maternal health conditions. Epigenetic mechanisms may play a crucial role in the interplay between genetic and environmental factors in the pathogenesis of ASD. In addition to language delay, pediatricians should monitor and screen for several early signs of ASD. Differential diagnosis is complex because several neurodevelopmental conditions show clinical features that overlap with ASD. Medications may be used to treat comorbid conditions.</div></div><div><h3>Conclusions</h3><div>Management is based on a multidisciplinary team, and pediatricians are in a unique position to coordinate this team, given the trustworthy relationship they have with patients and their families.</div></div>","PeriodicalId":14867,"journal":{"name":"Jornal de pediatria","volume":"102 ","pages":"Article 101458"},"PeriodicalIF":2.5,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145307823","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Jornal de pediatriaPub Date : 2026-03-01Epub Date: 2026-01-10DOI: 10.1016/j.jped.2025.101498
Gisele Bailich , Paulo Roberto Santos Lopes , Danubia da Cunha de Sá-Caputo , Alessandro Sartório , Gabriela Peixe , Mario Bernardo Filho , André Everton de Freitas , Anelise Sonza
{"title":"Infrared thermography in the assessment of brown and white adipose tissue in children with different nutritional states","authors":"Gisele Bailich , Paulo Roberto Santos Lopes , Danubia da Cunha de Sá-Caputo , Alessandro Sartório , Gabriela Peixe , Mario Bernardo Filho , André Everton de Freitas , Anelise Sonza","doi":"10.1016/j.jped.2025.101498","DOIUrl":"10.1016/j.jped.2025.101498","url":null,"abstract":"<div><h3>Objective</h3><div>To evaluate brown adipose tissue (BAT) and white adipose tissue using Infrared Thermography (IRT) in children with different nutritional statuses and correlate findings with anthropometric variables.</div></div><div><h3>Methods</h3><div>This cross-sectional observational study assessed body composition via bioelectrical impedance (BIA), skin temperature (supraclavicular and abdominal) through IRT, and anthropometric variables such as neck (NC), waist (WC), and hip (HC) circumferences. Calculations included waist-to-hip ratio (WHR) and conicity index (CI). Statistical analyses were performed in SPSS 20.0, with normality checked by the Shapiro-Wilk and homogeneity by Levene tests. Groups (eutrophic, overweight, obese) were compared using Pearson's Chi-square for categorical variables, Kruskal-Wallis, and ANOVA tests for quantitative data. Correlations were analyzed using Spearman's method. The significance level was set at p ≤ 0.05.</div></div><div><h3>Results</h3><div>Of 160 participants, 116 children were analyzed (eutrophic: N = 58; overweight: N = 26; obese: N = 32). Significant differences were noted between the eutrophic and obese groups. Supraclavicular temperature negatively correlated with BIA variables (total body water, fat-free mass, body fat percentage).</div></div><div><h3>Conclusions</h3><div>IRT demonstrated inverse correlations between BAT temperature and BMI, NC, WC, and HC, underscoring its potential in obesity risk analysis. IRT also offers quantitative assessments of BAT activity and may estimate body fat percentages, suggesting its relevance for monitoring adipose tissue function and metabolic effects of physical exercise.</div></div>","PeriodicalId":14867,"journal":{"name":"Jornal de pediatria","volume":"102 2","pages":"Article 101498"},"PeriodicalIF":2.5,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145862986","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Jornal de pediatriaPub Date : 2026-03-01Epub Date: 2026-02-06DOI: 10.1016/j.jped.2026.101501
Yan Han, Hong Zhao, Linchen Fu, Xinyi Jia, Xiao Du, Liqun Zhou, Jindan Yu, Jie Chen, Jingan Lou
{"title":"The utilization of oral feeding in pediatric pancreatitis: a randomized controlled study","authors":"Yan Han, Hong Zhao, Linchen Fu, Xinyi Jia, Xiao Du, Liqun Zhou, Jindan Yu, Jie Chen, Jingan Lou","doi":"10.1016/j.jped.2026.101501","DOIUrl":"10.1016/j.jped.2026.101501","url":null,"abstract":"<div><h3>Objective</h3><div>There is increasing awareness of the benefits of early nutritional intervention in children with acute pancreatitis (AP). This study aims to compare oral feeding with NG feeding in mild to moderately severe AP patients.</div></div><div><h3>Methods</h3><div>A single-center, prospective, randomized controlled trial was conducted from September 2021 to August 2024. The participants were randomly assigned to the oral feeding group or the NG feeding group. The primary outcomes were the duration of AP-related pain, tolerance rate, and changes in weight.</div></div><div><h3>Results</h3><div>A total of 56 pediatric patients were enrolled, of whom 48 patients (24 in each group) were included in the final analysis. There were no significant differences in baseline characteristics or etiological analysis results between the two groups. The median duration of abdominal pain after admission was 3 days in both groups (<em>p</em> = 0.104); no difference was found in the tolerance rate between the 2 cohorts (<em>p</em> = 0.489). There were no significant differences in weight change between the two groups at discharge or at 1 week or 5 weeks after discharge (<em>p</em> = 0.658, 0.502, and 0.927, respectively), and both groups presented slight increases in weight at 5 weeks post-discharge. Four patients in the NG group developed complications, while no complications were observed in the ORAL group (<em>p</em> = 0.109).</div></div><div><h3>Conclusions</h3><div>Oral feeding is effective for nutritional therapy in children with mild to moderately severe AP, reducing the number of invasive procedures, without significant adverse effects.</div></div>","PeriodicalId":14867,"journal":{"name":"Jornal de pediatria","volume":"102 2","pages":"Article 101501"},"PeriodicalIF":2.5,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146096892","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Jornal de pediatriaPub Date : 2026-03-01Epub Date: 2025-10-24DOI: 10.1016/j.jped.2025.101463
Eduardo Jorge Custódio da Silva , Evelyn Eisenstein
{"title":"Transition to adolescence in neurodevelopmental disorders: challenges and clinical perspectives","authors":"Eduardo Jorge Custódio da Silva , Evelyn Eisenstein","doi":"10.1016/j.jped.2025.101463","DOIUrl":"10.1016/j.jped.2025.101463","url":null,"abstract":"<div><h3>Objective</h3><div>This review article describes the main clinical, emotional, educational, and social aspects involved in the transition to adolescence for individuals with these conditions. It also addresses implications for healthcare, the continuity of educational support, and the importance of individualized transition strategies, highlighting the need for a multidisciplinary approach centered on the individual and on continuity of care.</div></div><div><h3>Data sources</h3><div>Review of the latest literature on neurodevelopmental disorders in adolescents.</div></div><div><h3>Data summary</h3><div>Adolescence represents a vital period of biopsychosocial transformation, particularly challenging for individuals with neurodevelopmental disorders (NDDs), such as autism spectrum disorder (ASD), attention-deficit/hyperactivity disorder (ADHD), and intellectual disability.</div></div><div><h3>Conclusions</h3><div>Integrated, person-centered, continuous, and collaborative health care is essential to promote the well-being and inclusion of these adolescents.</div></div>","PeriodicalId":14867,"journal":{"name":"Jornal de pediatria","volume":"102 ","pages":"Article 101463"},"PeriodicalIF":2.5,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145345092","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Jornal de pediatriaPub Date : 2026-03-01Epub Date: 2026-02-08DOI: 10.1016/j.jped.2026.101504
Thalles de Souza Freire, Mandira Daripa Kawakami, Maria Fernanda de Almeida, Ruth Guinsburg
{"title":"Impact of electrocardiogram monitoring on the frequency of tracheal intubation at birth","authors":"Thalles de Souza Freire, Mandira Daripa Kawakami, Maria Fernanda de Almeida, Ruth Guinsburg","doi":"10.1016/j.jped.2026.101504","DOIUrl":"10.1016/j.jped.2026.101504","url":null,"abstract":"<div><h3>Objective</h3><div>To determine whether the use of an electrocardiogram monitor in newborns receiving positive pressure ventilation (PPV) at birth affects the frequency of tracheal intubation in the delivery room.</div></div><div><h3>Methods</h3><div>Retrospective cohort of liveborn infants without congenital anomalies, with gestational age (GA) ≥ 23 weeks and birth weight ≥ 400 <em>g</em> who received PPV at birth, from 2014 to 2022. Newborns were stratified by GA (< 34 or ≥ 34 weeks) and by use or non-use of an electrocardiogram monitor during resuscitation. Logistic regression was used to assess the association between electrocardiogram monitoring and outcomes of interest for each GA group.</div></div><div><h3>Results</h3><div>Among 5622 live births, 516 met the inclusion criteria; 224 (43 %) were monitored, and 292 (57 %) were not. The frequency of tracheal intubation was similar between monitored and non-monitored groups: ≥ 34 weeks - 13 % vs. 14 %; < 34 weeks - 43 % vs. 43 %. Electrocardiogram monitoring increased the odds of initiating PPV with a face mask ≥ 60 seconds after birth by 2.45-fold (95 % CI: 1.08–5.54) for GA ≥ 34 weeks and by 2.72-fold (95 % CI: 1.13–6.59) for GA < 34 weeks, after adjustment for umbilical cord clamping time, year of birth, and birth weight.</div></div><div><h3>Conclusion</h3><div>Electrocardiogram monitor use did not reduce the frequency of tracheal intubation and was associated with delayed initiation of PPV with a face mask.</div></div>","PeriodicalId":14867,"journal":{"name":"Jornal de pediatria","volume":"102 2","pages":"Article 101504"},"PeriodicalIF":2.5,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146096866","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Jornal de pediatriaPub Date : 2026-03-01Epub Date: 2026-02-17DOI: 10.1016/j.jped.2026.101509
Luciana G. Barcellos , Fernanda M. Rubin , Ana Paula P. da Silva , Júlia L. Vieira , Luciane G. da Cunha , Lucinara V. Enéas Machado , Geniara da S. Conrado , Cristian T. Tonial
{"title":"PIM2, lactate, and trauma score to predict mortality in critically ill pediatric trauma patients","authors":"Luciana G. Barcellos , Fernanda M. Rubin , Ana Paula P. da Silva , Júlia L. Vieira , Luciane G. da Cunha , Lucinara V. Enéas Machado , Geniara da S. Conrado , Cristian T. Tonial","doi":"10.1016/j.jped.2026.101509","DOIUrl":"10.1016/j.jped.2026.101509","url":null,"abstract":"<div><h3>Objective</h3><div>To evaluate the prognostic performance of the Pediatric Index of Mortality 2 (PIM2), serum lactate, and Pediatric Trauma Score (PTS) for mortality in a large case series of critically ill pediatric trauma patients admitted to a specialized PICU in Brazil.</div></div><div><h3>Methods</h3><div>Retrospective case series conducted in the Pediatric Intensive Care Unit of a tertiary trauma hospital in Brazil. All trauma patients aged 1 month to 18 years admitted between March 2018 and March 2025 and hospitalized for >24 h were eligible (<em>n</em> = 1495). Demographic, clinical, and laboratory data were collected, including PIM2, initial lactate, and PTS. The primary outcome was all-cause PICU mortality.</div></div><div><h3>Results</h3><div>Death occurred in 1.5% of patients. ROC curve analysis was performed in 620 patients with complete data for the three markers. Areas under the curve (AUCs) were: PIM2, 0.93 (95% CI, 0.91–0.95); lactate, 0.86 (95% CI, 0.83–0.88); and PTS, 0.82 (95% CI, 0.79–0.85). In univariable logistic regression, all markers were independently associated with mortality. A 10-fold increase in PIM2 and lactate raised death odds by 36-fold and 226-fold, respectively, while each point increase in PTS reduced odds by 34.6%. In the multivariable model, PIM2 and lactate remained significant predictors.</div></div><div><h3>Conclusions</h3><div>PIM2 and lactate remained independently associated with mortality after mutual adjustment in pediatric trauma patients admitted to a specialized PICU. PTS, while valuable for prehospital triage, added little once intensive care was initiated.</div></div>","PeriodicalId":14867,"journal":{"name":"Jornal de pediatria","volume":"102 2","pages":"Article 101509"},"PeriodicalIF":2.5,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146113185","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Jornal de pediatriaPub Date : 2026-03-01Epub Date: 2026-02-28DOI: 10.1016/j.jped.2026.101512
Laura Cudizio, Isadora R. Brambilla, Kayleigh G. Marques de Araújo, Raquel G. Lot, Tayana O. Martins, Raquel R. Biasi, Giuliane Galeote, Aline D. Costa-Riquetto, João Eduardo N. Salles, Luis Eduardo Calliari
{"title":"Families’ perspectives and the development of an educational program for diabetes in schools","authors":"Laura Cudizio, Isadora R. Brambilla, Kayleigh G. Marques de Araújo, Raquel G. Lot, Tayana O. Martins, Raquel R. Biasi, Giuliane Galeote, Aline D. Costa-Riquetto, João Eduardo N. Salles, Luis Eduardo Calliari","doi":"10.1016/j.jped.2026.101512","DOIUrl":"10.1016/j.jped.2026.101512","url":null,"abstract":"<div><h3>Objective</h3><div>The number of children with type 1 diabetes (CwD) is rising globally, increasing demand for school-based support. The primary objective was to assess parents’ perceptions of the current state of diabetes care in schools for CwD. The secondary objective was to gather feedback on a comprehensive educational program offered to participants.</div></div><div><h3>Methods</h3><div>Families of CwD attending an outpatient clinic completed a survey about diabetes care offered by schools. A comprehensive diabetes educational program was developed, comprising a mobile application, website, and printed diabetes management plan. The program was presented to the families to facilitate communication with school staff.</div></div><div><h3>Results</h3><div>A total of 107 families participated (mean age of students 10.7 ± 3.9 years; mean age at diagnosis 5.4 ± ± 3.3 years). Most were from the São Paulo metropolitan area (94.3%; 27 cities) and attended public schools (89.7%). Mean HbA1c was 8.8% ± 2.1 (75). Family members often provided in-school insulin support (25.2% overall; 55% of children < 6 years; <em>p</em> < 0.05). Nearly half of caregivers (45.8%) reduced working hours due to diabetes care (55.2% for children < 6 years; 0.05). Most families (73.8%) reported schools had little or no knowledge of diabetes, and 31.8% were dissatisfied with the care received. The possibility of having diabetes material specifically directed to schools was valued by the families and patients.</div></div><div><h3>Conclusion</h3><div>Families of CwD in the São Paulo metropolitan area face challenges in school settings. Providing educational materials in different formats is necessary, but strategies are needed to involve school staff in the management actively.</div></div>","PeriodicalId":14867,"journal":{"name":"Jornal de pediatria","volume":"102 2","pages":"Article 101512"},"PeriodicalIF":2.5,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146149851","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Jornal de pediatriaPub Date : 2026-03-01Epub Date: 2026-02-17DOI: 10.1016/j.jped.2026.101519
Dongqing Gu , Xiaofei Zheng , Yan Zhou , Fengjie Tan , Rui Gui , Linna Wei , Lubin Liu
{"title":"Neonatal mortality trends in the 21st century: findings from the Global Burden of Disease Study 2021","authors":"Dongqing Gu , Xiaofei Zheng , Yan Zhou , Fengjie Tan , Rui Gui , Linna Wei , Lubin Liu","doi":"10.1016/j.jped.2026.101519","DOIUrl":"10.1016/j.jped.2026.101519","url":null,"abstract":"<div><h3>Objective</h3><div>Neonatal mortality remains a significant global health challenge, particularly in low- and middle-income countries. This study aimed to analyze the trends and causes of neonatal mortality from 2000 to 2021.</div></div><div><h3>Methods</h3><div>Data on all-cause and cause-specific mortality were obtained from the Global Burden of Disease Study 2021. Joinpoint regressions were employed to calculate the annual percentage change and the average annual percentage change. Pearson's correlation was utilized to estimate the relationships between mortality rates and the Human Development Index.</div></div><div><h3>Results</h3><div>The global all-cause neonatal mortality rate has declined by an average of 2.1% per year since 2000, while the absolute number of neonatal deaths remained at 2.19 million globally in 2021. Neonatal disorders continued to be the leading cause of death among neonates in 2021, followed by congenital birth defects, lower respiratory infections, sexually transmitted infections excluding HIV, diarrheal diseases, and malaria. The neonatal mortality rate varied significantly across different countries and territories, ranging from 0.61 per 1000 livebirths in Andorra to 55.35 per 1000 livebirths in South Sudan. By 2021, 120 countries (58.8%) had achieved the Sustainable Development Goal 3.2 target. Additionally, strong negative correlations were found between mortality rates and Human Development Index (<em>r</em> = -0.867, <em>P</em> < 0.001).</div></div><div><h3>Conclusions</h3><div>Despite significant progress, regional disparities persist; only half of the countries achieved the Sustainable Development Goal 3.2 target by 2021. These findings emphasize prioritized interventions for neonatal disorders in low/middle-income countries and highlight socioeconomic development as critical to equitable mortality reduction within public health frameworks.</div></div>","PeriodicalId":14867,"journal":{"name":"Jornal de pediatria","volume":"102 2","pages":"Article 101519"},"PeriodicalIF":2.5,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146194751","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}