Jornal Brasileiro De Pneumologia最新文献

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Evaluation of the accuracy of ChatGPT in answering asthma-related questions. 评价ChatGPT在回答哮喘相关问题中的准确性。
IF 3 4区 医学
Jornal Brasileiro De Pneumologia Pub Date : 2025-09-08 eCollection Date: 2025-01-01 DOI: 10.36416/1806-3756/e20240388
Bruno Pellozo Cerqueira, Vinicius Cappellette da Silva Leite, Carla Gonzaga França, Fernando Sergio Leitão Filho, Sonia Maria Faresin, Ricardo Gassmann Figueiredo, Andrea Antunes Cetlin, Lilian Serrasqueiro Ballini Caetano, José Baddini-Martinez
{"title":"Evaluation of the accuracy of ChatGPT in answering asthma-related questions.","authors":"Bruno Pellozo Cerqueira, Vinicius Cappellette da Silva Leite, Carla Gonzaga França, Fernando Sergio Leitão Filho, Sonia Maria Faresin, Ricardo Gassmann Figueiredo, Andrea Antunes Cetlin, Lilian Serrasqueiro Ballini Caetano, José Baddini-Martinez","doi":"10.36416/1806-3756/e20240388","DOIUrl":"10.36416/1806-3756/e20240388","url":null,"abstract":"<p><strong>Objective: </strong>To evaluate the quality of ChatGPT answers to asthma-related questions, as assessed from the perspectives of asthma specialists and laypersons.</p><p><strong>Methods: </strong>Seven asthma-related questions were asked to ChatGPT (version 4) between May 3, 2024 and May 4, 2024. The questions were standardized with no memory of previous conversations to avoid bias. Six pulmonologists with extensive expertise in asthma acted as judges, independently assessing the quality and reproducibility of the answers from the perspectives of asthma specialists and laypersons. A Likert scale ranging from 1 to 4 was used, and the content validity coefficient was calculated to assess the level of agreement among the judges.</p><p><strong>Results: </strong>The evaluations showed variability in the quality of the answers provided by ChatGPT. From the perspective of asthma specialists, the scores ranged from 2 to 3, with greater divergence in questions 2, 3, and 5. From the perspective of laypersons, the content validity coefficient exceeded 0.80 for four of the seven questions, with most answers being correct despite a lack of significant depth.</p><p><strong>Conclusions: </strong>Although ChatGPT performed well in providing answers to laypersons, the answers that it provided to specialists were less accurate and superficial. Although AI has the potential to provide useful information to the public, it should not replace medical guidance. Critical analysis of AI-generated information remains essential for health care professionals and laypersons alike, especially for complex conditions such as asthma.</p>","PeriodicalId":14845,"journal":{"name":"Jornal Brasileiro De Pneumologia","volume":"51 3","pages":"e20240388"},"PeriodicalIF":3.0,"publicationDate":"2025-09-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12401147/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145033128","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Aerobic capacity after lung resection in patients with COPD. COPD患者肺切除术后的有氧能力。
IF 3 4区 医学
Jornal Brasileiro De Pneumologia Pub Date : 2025-09-08 DOI: 10.36416/1806-3756/e20240361
Danielle C C Bedin, Roberta P Ramos, Elaine Brito Vieira, Ivan Ivanaga, Sonia M Faresin
{"title":"Aerobic capacity after lung resection in patients with COPD.","authors":"Danielle C C Bedin, Roberta P Ramos, Elaine Brito Vieira, Ivan Ivanaga, Sonia M Faresin","doi":"10.36416/1806-3756/e20240361","DOIUrl":"10.36416/1806-3756/e20240361","url":null,"abstract":"","PeriodicalId":14845,"journal":{"name":"Jornal Brasileiro De Pneumologia","volume":"51 3","pages":"e20240361"},"PeriodicalIF":3.0,"publicationDate":"2025-09-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12401116/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145033332","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Results of radiotherapy for thymoma: retrospective cohort and propensity score matching analysis. 胸腺瘤放射治疗的结果:回顾性队列和倾向评分匹配分析。
IF 3 4区 医学
Jornal Brasileiro De Pneumologia Pub Date : 2025-09-08 eCollection Date: 2025-01-01 DOI: 10.36416/1806-3756/e20240331
Jordana de Paula Soares, Gabriel Faria Najas, Geovanne Pedro Mauro, Kennya Medeiros Lopes de Barros Lima, Clarissa Cerchi Angotti Ramos, Pedro Henrique Xavier Nabuco de Araujo, Heloisa de Andrade Carvalho
{"title":"Results of radiotherapy for thymoma: retrospective cohort and propensity score matching analysis.","authors":"Jordana de Paula Soares, Gabriel Faria Najas, Geovanne Pedro Mauro, Kennya Medeiros Lopes de Barros Lima, Clarissa Cerchi Angotti Ramos, Pedro Henrique Xavier Nabuco de Araujo, Heloisa de Andrade Carvalho","doi":"10.36416/1806-3756/e20240331","DOIUrl":"10.36416/1806-3756/e20240331","url":null,"abstract":"<p><strong>Objective: </strong>Thymic tumors are a rare group of anterior mediastinal tumors. Surgery is the primary treatment. Adjuvant treatment is used in select cases. The purpose of this study was to evaluate the outcomes of patients with thymic tumors, submitted or not to radiotherapy, and identify risk factors that could impact the outcomes to better support patient selection for RT.</p><p><strong>Methods: </strong>This is a single institution retrospective cohort study. Patients with histologically proven thymoma or thymic carcinoma treated from July of 2009 to November of 2020 were included. Analysis was based on the use of radiation therapy (RT). Overall survival and disease-free survival were assessed from the date of diagnosis. To minimize selection bias, propensity score matching (PSM) regression using Kernel matching was used, estimated on the population for average treatment effect.</p><p><strong>Results: </strong>Overall, 101 patients were analyzed, with mean age at diagnosis of 54.6 years (range 25-84 years). Unfavorable histology and more advanced stages predominated in the cohort. Nevertheless, most (69.3%) were treated with radical intent. RT was delivered in 52.9% of these patients. Five-year OS, local progression and distant progression free survivals were 81.0%, 95.0% and 88.1%, respectively for the radical intent cohort. PSM showed that RT reduced the chances of death by 6.3% (matched sample size was 60, p = 0.02).</p><p><strong>Conclusions: </strong>In this retrospective cohort, RT had a positive impact in OS after PSM analysis. Prospective data regarding the role of RT in this disease is needed to validate these findings.</p>","PeriodicalId":14845,"journal":{"name":"Jornal Brasileiro De Pneumologia","volume":"51 3","pages":"e20240331"},"PeriodicalIF":3.0,"publicationDate":"2025-09-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12401149/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145033146","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Baseline characteristics of patients from the Brazilian Severe Asthma Registry: the REBRAG study. 巴西严重哮喘登记患者的基线特征:REBRAG研究
IF 3 4区 医学
Jornal Brasileiro De Pneumologia Pub Date : 2025-09-08 eCollection Date: 2025-01-01 DOI: 10.36416/1806-3756/e20240427
Paulo Marcio Pitrez, Débora Carla Chong-Silva, Faradiba Sarquis Serpa, Adelmir Souza-Machado, Adalberto Sperb Rubin, Amanda da Rocha Oliveira Cardoso, Adyléia Aparecida Dalbo Contrera Toro, Laura Maria de Lima Belizario Facury Lasmar, Daniela Cavalet Blanco, Luciana de Freitas Velloso Monte, Marina Andrade Lima, José Gustavo Barian Romaldini, Eduardo Costa de Freitas Silva, Kamila Ticiana Dias Ferreira, Alvaro Augusto Souza da Cruz Filho, Marcia Margaret Menezes Pizzichini
{"title":"Baseline characteristics of patients from the Brazilian Severe Asthma Registry: the REBRAG study.","authors":"Paulo Marcio Pitrez, Débora Carla Chong-Silva, Faradiba Sarquis Serpa, Adelmir Souza-Machado, Adalberto Sperb Rubin, Amanda da Rocha Oliveira Cardoso, Adyléia Aparecida Dalbo Contrera Toro, Laura Maria de Lima Belizario Facury Lasmar, Daniela Cavalet Blanco, Luciana de Freitas Velloso Monte, Marina Andrade Lima, José Gustavo Barian Romaldini, Eduardo Costa de Freitas Silva, Kamila Ticiana Dias Ferreira, Alvaro Augusto Souza da Cruz Filho, Marcia Margaret Menezes Pizzichini","doi":"10.36416/1806-3756/e20240427","DOIUrl":"10.36416/1806-3756/e20240427","url":null,"abstract":"<p><strong>Objective: </strong>To describe the impact of severe asthma in a real-life cohort in Brazil, reporting on baseline clinical characteristics, access to treatment, and clinical remission under treatment with biologics.</p><p><strong>Methods: </strong>Severe asthma patients > 6 years of age were recruited from 23 centers in Brazil. Data on clinical characteristics, lung function, biomarkers, prescribed therapies, and clinical remission under treatment were collected at the baseline visit.</p><p><strong>Results: </strong>A total of 417 patients were recruited. Of the 162 adult patients, 71% had a history of hospitalization, with 31% having experienced more than two severe exacerbations in the last 12 months and 6% having experienced cardiopulmonary arrest. Allergic and eosinophilic phenotypes were the most common phenotypes in all age groups, with the T2-low phenotype being observed in 10% of the pediatric patients and in 20% of the adult patients. Only 10% of the adult patients and 1% of the pediatric patients were receiving maintenance oral corticosteroids, whereas 41% of the adult patients were under treatment with biologics, with clinical remission being achieved in 20%.</p><p><strong>Conclusions: </strong>Severe asthma in Brazil still results in a high disease burden, with less than half of the patients receiving treatment with biologics and clinical remission being achieved in a subgroup of patients treated with biologics for more than 12 months. Achieving disease control remains a major clinical and health care challenge, requiring further actions from specialists and health care providers, as well as additional studies.</p>","PeriodicalId":14845,"journal":{"name":"Jornal Brasileiro De Pneumologia","volume":"51 3","pages":"e20240427"},"PeriodicalIF":3.0,"publicationDate":"2025-09-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12401096/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145033417","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Sociodemographic and clinical characteristics of individuals exposed to smoking or biomass smoke and followed at primary health care centers in Brazil: a multicenter study. 巴西初级卫生保健中心暴露于吸烟或生物质烟雾的个体的社会人口学和临床特征:一项多中心研究
IF 3 4区 医学
Jornal Brasileiro De Pneumologia Pub Date : 2025-09-08 eCollection Date: 2025-01-01 DOI: 10.36416/1806-3756/e20250001
Juliana O Barros, Flavio F Arbex, Alcindo Cerci Neto, Leandro G Fritscher, Suzana E Tanni, Gerson F Souza, Oliver A Nascimento, José R Jardim
{"title":"Sociodemographic and clinical characteristics of individuals exposed to smoking or biomass smoke and followed at primary health care centers in Brazil: a multicenter study.","authors":"Juliana O Barros, Flavio F Arbex, Alcindo Cerci Neto, Leandro G Fritscher, Suzana E Tanni, Gerson F Souza, Oliver A Nascimento, José R Jardim","doi":"10.36416/1806-3756/e20250001","DOIUrl":"10.36416/1806-3756/e20250001","url":null,"abstract":"<p><strong>Objective: </strong>To describe the sociodemographic and clinical characteristics of individuals exposed to smoking or biomass smoke and followed at primary health care (PHC) centers across three states in Brazil.</p><p><strong>Methods: </strong>This was a cross-sectional multicenter study including patients followed at any of four PHC centers in Brazil. Patients ≥ 35 years of age who were smokers or former smokers, or were exposed to biomass smoke were included, the exception being those with physical/mental disabilities and those who were pregnant. Face-to-face assessments included a questionnaire assessing clinical and sociodemographic characteristics, as well as the COPD Assessment Test (CAT) and the modified Medical Research Council (mMRC) dyspnea scale.</p><p><strong>Results: </strong>Of a total of 737 patients, 56.3% were female and 64.2% were White, with a mean age of 57.7 ± 11.8 years. Most (54.4%) had < 9 years of schooling, 50.2% had low socioeconomic status, and 71.5% were overweight/obese. Smokers accounted for 43.4% of the study sample, whereas 15.0% had no direct exposure to cigarette smoke. Common symptoms included cough, in 37.3%; wheezing, in 33.8%; and phlegm, in 27.4%. Most (75.1%) of the study participants had mMRC dyspnea scale scores of 0 or 1. CAT scores were 0-10, in 40.2%; 11-20, in 44.6%; 21-30, in 14.1%; and 31-40, in 1.1%. Binary logistic regression showed that sex and age significantly impacted mMRC dyspnea scale predictions, whereas BMI and socioeconomic status influenced CAT predictions. Common comorbidities included hypertension, in 51.3%; depression, in 27.4%; and diabetes, in 24.3%. No association was found between hypertension and obesity or smoking, or between diabetes and obesity or smoking.</p><p><strong>Conclusions: </strong>PHC patients with risk factors such as smoking and exposure to biomass smoke have a high comorbidity burden, with over half experiencing mild to moderate quality-of-life impacts. This study emphasizes the need for targeted preventive measures in PHC settings.</p>","PeriodicalId":14845,"journal":{"name":"Jornal Brasileiro De Pneumologia","volume":"51 3","pages":"e20250001"},"PeriodicalIF":3.0,"publicationDate":"2025-09-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12401088/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145033171","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Indocyanine green used in association with a surgical hemostatic agent as a fiducial marker to reduce overflow during robot-assisted thoracic surgery. 吲哚菁绿与外科止血剂联合使用,作为机器人辅助胸外科手术中减少血流溢出的基准标记物。
IF 3 4区 医学
Jornal Brasileiro De Pneumologia Pub Date : 2025-09-08 DOI: 10.36416/1806-3756/e20250090
Guilherme Falleiros Mendes, Marcelo Froeder Arcuri, Priscila Mina Falsarella, Alberto Rassi Neto, Rodrigo Gobbo Garcia
{"title":"Indocyanine green used in association with a surgical hemostatic agent as a fiducial marker to reduce overflow during robot-assisted thoracic surgery.","authors":"Guilherme Falleiros Mendes, Marcelo Froeder Arcuri, Priscila Mina Falsarella, Alberto Rassi Neto, Rodrigo Gobbo Garcia","doi":"10.36416/1806-3756/e20250090","DOIUrl":"10.36416/1806-3756/e20250090","url":null,"abstract":"","PeriodicalId":14845,"journal":{"name":"Jornal Brasileiro De Pneumologia","volume":"51 3","pages":"e20250090"},"PeriodicalIF":3.0,"publicationDate":"2025-09-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12401154/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145033189","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Inhaler identification: evaluating a potential screening method for adherence in chronic respiratory disease management. 吸入器识别:评估慢性呼吸道疾病管理中依从性的潜在筛查方法。
IF 3 4区 医学
Jornal Brasileiro De Pneumologia Pub Date : 2025-09-08 eCollection Date: 2025-01-01 DOI: 10.36416/1806-3756/e20250393
David Silva Gomes, Carlos Seixas, João Cravo
{"title":"Inhaler identification: evaluating a potential screening method for adherence in chronic respiratory disease management.","authors":"David Silva Gomes, Carlos Seixas, João Cravo","doi":"10.36416/1806-3756/e20250393","DOIUrl":"10.36416/1806-3756/e20250393","url":null,"abstract":"<p><strong>Objectives: </strong>This study explores the relationship between inhaler visual identification, naming, and adherence outcomes, and evaluates the potential of combining these factors into a screening tool for identifying poor adherence.</p><p><strong>Methods: </strong>This observational, prospective study included adult patients with COPD, asthma, or asthma+COPD who had been on chronic inhalation therapy for at least the past year. Data were collected through patient interviews and medical records. Adherence was assessed using the Test of Adherence to Inhalers (TAI) questionnaire and prescription records, calculated as the Proportion of Days Covered (PDC). The patients completed a questionnaire to evaluate their ability to visually identify and name their inhalers.</p><p><strong>Results: </strong>Among the 196 participants, significant differences in adherence levels were observed across the COPD, asthma, and asthma+COPD groups, with COPD patients demonstrating higher adherence rates (p=0.001). Concordance between TAI and PDC was highest in the COPD group (75.0%), compared to the asthma (51.3%) and asthma+COPD (55.5%) groups. Correct naming of inhalers was not significantly correlated with adherence. However, correct inhaler visual identification was associated with better adherence. Incorrect visual identification showed low sensitivity (15.9%) but high specificity (92.6%) for detecting poorly adherent patients.</p><p><strong>Conclusions: </strong>The ability to visually identify inhalers was associated with better adherence, while the ability to name inhalers was not. Although incorrect visual identification has limited utility as a screening tool, it may still serve as a rapid and practical method for identifying poorly adherent patients in clinical practice.</p>","PeriodicalId":14845,"journal":{"name":"Jornal Brasileiro De Pneumologia","volume":"51 3","pages":"e20250393"},"PeriodicalIF":3.0,"publicationDate":"2025-09-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12401153/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145033147","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The staging evolution dilemma: TNM-9 sharpens anatomical precision, but is biology still offstage? 分期进化困境:TNM-9提高了解剖精度,但生物学是否仍处于幕后?
IF 3 4区 医学
Jornal Brasileiro De Pneumologia Pub Date : 2025-09-08 DOI: 10.36416/1806-3756/e20250236
Gustavo Faibischew Prado, Fernanda Kaori Fujiki, João Marcelo Lopes Toscano de Brito
{"title":"The staging evolution dilemma: TNM-9 sharpens anatomical precision, but is biology still offstage?","authors":"Gustavo Faibischew Prado, Fernanda Kaori Fujiki, João Marcelo Lopes Toscano de Brito","doi":"10.36416/1806-3756/e20250236","DOIUrl":"10.36416/1806-3756/e20250236","url":null,"abstract":"","PeriodicalId":14845,"journal":{"name":"Jornal Brasileiro De Pneumologia","volume":"51 3","pages":"e20250236"},"PeriodicalIF":3.0,"publicationDate":"2025-09-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12401150/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145033213","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Post-tuberculosis and postinfected bronchiectasis: data from global registries. 结核后和感染后支气管扩张:来自全球登记的数据。
IF 3 4区 医学
Jornal Brasileiro De Pneumologia Pub Date : 2025-09-08 DOI: 10.36416/1806-3756/e20250153
Grace Oscullo, Miguel-Angel Martinez-García, Rosella Centis, Lia D'Ambrosio, Jose Daniel Gómez-Olivas, Giovanni Battista Migliori
{"title":"Post-tuberculosis and postinfected bronchiectasis: data from global registries.","authors":"Grace Oscullo, Miguel-Angel Martinez-García, Rosella Centis, Lia D'Ambrosio, Jose Daniel Gómez-Olivas, Giovanni Battista Migliori","doi":"10.36416/1806-3756/e20250153","DOIUrl":"10.36416/1806-3756/e20250153","url":null,"abstract":"","PeriodicalId":14845,"journal":{"name":"Jornal Brasileiro De Pneumologia","volume":"51 3","pages":"e20250153"},"PeriodicalIF":3.0,"publicationDate":"2025-09-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12401148/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145033218","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Influence of ADRB2 variants on bronchodilator response and asthma control in a mixed population. ADRB2变异对混合人群支气管扩张剂反应和哮喘控制的影响
IF 3 4区 医学
Jornal Brasileiro De Pneumologia Pub Date : 2025-08-18 eCollection Date: 2025-01-01 DOI: 10.36416/1806-3756/e20250066
Pedro Augusto Silva Dos Santos Rodrigues, Álvaro Augusto Souza da Cruz Filho, Helena Mariana Pitangueira Teixeira, Luciano Gama da Silva Gomes, Hatilla Dos Santos Silva, Juliana Lopes Rodrigues, Almirane Lima de Oliveira, Cinthia Vila Nova Santana, Gabriela Pimentel Pinheiro das Chagas, Camila Alexandrina Viana de Figueiredo, Ryan Dos Santos Costa
{"title":"Influence of ADRB2 variants on bronchodilator response and asthma control in a mixed population.","authors":"Pedro Augusto Silva Dos Santos Rodrigues, Álvaro Augusto Souza da Cruz Filho, Helena Mariana Pitangueira Teixeira, Luciano Gama da Silva Gomes, Hatilla Dos Santos Silva, Juliana Lopes Rodrigues, Almirane Lima de Oliveira, Cinthia Vila Nova Santana, Gabriela Pimentel Pinheiro das Chagas, Camila Alexandrina Viana de Figueiredo, Ryan Dos Santos Costa","doi":"10.36416/1806-3756/e20250066","DOIUrl":"https://doi.org/10.36416/1806-3756/e20250066","url":null,"abstract":"<p><strong>Objective: </strong>Given that b2 agonists constitute the primary treatment for asthma and that treatment response varies as a result of polymorphisms in the ADRB2 gene, we sought to investigate the associations between ADRB2 gene variants and bronchodilator response (BDR) in asthma patients.</p><p><strong>Methods: </strong>A genetic database comprising 813 individuals was analyzed for variants in the ADRB2 gene. A longitudinal analysis of severe asthma patients was performed to evaluate changes in BDR over time.</p><p><strong>Results: </strong>The rs1042713, rs1042714, and rs1042717 variants were associated with age-related changes in BDR in patients with severe asthma. The G allele (rs1042714) and the A allele (rs1042717) were associated with uncontrolled asthma, with carriers of the G46/G79/A252 alleles showing a higher risk of difficult-to-control asthma. Notably, no association was found between these variants and ADRB2 expression levels.</p><p><strong>Conclusions: </strong>Our findings suggest that a genetic panel including ADRB2 variants, as well as age-related differences in BDR, is a useful complementary tool in asthma management.</p>","PeriodicalId":14845,"journal":{"name":"Jornal Brasileiro De Pneumologia","volume":"51 4","pages":"e20250066"},"PeriodicalIF":3.0,"publicationDate":"2025-08-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12401121/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144954961","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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