Jornal Brasileiro De Pneumologia最新文献

{"title":"Is health-related quality of life significantly different in very elderly patients receiving home mechanical ventilation?","authors":"Teresa Machado, Tiago Sá, Pedro Viegas, Leonor Roseta, Carla Ribeiro","doi":"10.36416/1806-3756/e20250230","DOIUrl":"10.36416/1806-3756/e20250230","url":null,"abstract":"","PeriodicalId":14845,"journal":{"name":"Jornal Brasileiro De Pneumologia","volume":"51 6","pages":"e20250230"},"PeriodicalIF":3.6,"publicationDate":"2026-06-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13209639/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148264681","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The microbiological diagnosis of pediatric tuberculosis: focus on the Ultra test.","authors":"Claudia Stella Pereira Battaglia, Rafaela Baroni Aurilio, Michley Alexandrino Pinheiro, Ana Alice Amaral Ibiapina Parente, Ronir Raggio Luiz, Clemax Couto Sant Anna, Maria de Fatima B Pombo Sant Anna","doi":"10.36416/1806-3756/e20250241","DOIUrl":"10.36416/1806-3756/e20250241","url":null,"abstract":"<p><strong>Introduction: </strong>GeneXpert® MTB/RIF Ultra (Ultra) is a method for detecting the Mycobacterium tuberculosis complex (Mtb) with greater sensitivity compared to GeneXpert® MTB/RIF (Xpert). In Brazil, for children and for extrapulmonary tuberculosis (EPTB), \"traces detected\" results are considered positive for Mtb. Here, we describe the use of Ultra at a reference center for pediatric tuberculosis (TB) in Rio de Janeiro, Brazil.</p><p><strong>Methods: </strong>A cross-sectional study was conducted with children (0-9 years) and adolescents (10-18 years) with presumed EPTB or pulmonary TB (PTB) whose specimens were tested using Ultra. Data were analyzed using descriptive statistics, and Fisher's exact test (significance level p<0.05) was applied when appropriate. The study was approved by the Ethics Committee of IPPMG-UFRJ (CAAE: 02173518.2.0000.5264).</p><p><strong>Results: </strong>Ninety-three patients with presumed TB were included: 44% with PTB and 56% with EPTB. The final diagnoses revealed 63.4% PTB, 40.4% EPTB, and 49.5% other diagnoses. Among the PTB cases, 9/26 (34%) had positive results exclusively by Ultra. As for the EPTB cases, 11/21 (52%) were positive only by Ultra. For PTB, sensitivity was 50% and specificity was 100% (compared to culture). For EPTB, sensitivity was 85.7% and specificity was 100%.</p><p><strong>Conclusion: </strong>Ultra contributed to the diagnosis of both PTB and EPTB, especially in cases with negative culture results. The test demonstrated higher sensitivity in EPTB than in PTB.</p>","PeriodicalId":14845,"journal":{"name":"Jornal Brasileiro De Pneumologia","volume":"51 6","pages":"e20250241"},"PeriodicalIF":3.6,"publicationDate":"2026-06-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13209859/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148264636","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The role of ultrasound of the quadriceps femoris in people with cystic fibrosis: a systematic review and meta-analysis.","authors":"Jorge Eduardo Cortz Sernaglia, Aline Priscila de Souza, Aline Cristina Gonçalves, Daniela de Souza Paiva Borgli, Carla Cristina Souza Gomez, José Dirceu Ribeiro","doi":"10.36416/1806-3756/e20250232","DOIUrl":"10.36416/1806-3756/e20250232","url":null,"abstract":"<p><strong>Objective: </strong>To conduct a systematic review and meta-analysis of the evidence on the use of ultrasound to assess quadriceps morphology in people with cystic fibrosis (PwCF), focusing on muscle thickness, cross-sectional area, and associations with clinical outcomes.</p><p><strong>Methods: </strong>This study followed the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines and was registered on the International Prospective Register of Systematic Reviews platform (ID: CRD42024590549). The PubMed, Embase, Scopus, Web of Science, SciELO, and Cumulative Index to Nursing and Allied Health Literature databases were comprehensively searched without time restrictions. Gray literature and manual reference screening were also included. Observational studies assessing quadriceps morphology via ultrasound in people with CF and reporting quantitative outcomes were eligible. Two reviewers independently conducted study selection, data extraction, and risk of bias assessment using the Joanna Briggs Institute tool. Meta-analysis was performed with Cochrane's Review Manager software.</p><p><strong>Results: </strong>Five studies met the inclusion criteria. People with CF showed reduced quadriceps thickness and cross-sectional area, particularly those who were malnourished. Moderate correlations were observed between ultrasound measurements and clinical parameters such as pulmonary function, fat-free mass index, and muscle strength. Meta-analysis revealed a significant reduction in rectus femoris muscle thickness in people with CF when compared with controls (mean difference: -0.50 cm; 95% CI, -0.78 to -0.22; p = 0.0004), with high heterogeneity (I2 = 94%). Risk of bias was moderate because of small sample sizes and methodological variability.</p><p><strong>Conclusions: </strong>Although the evidence is limited and heterogeneous, people with CF appear to show reduced quadriceps morphology, with associations with nutritional and functional status. Further high-quality studies are needed to confirm our findings and determine the clinical utility of ultrasound in this population.</p>","PeriodicalId":14845,"journal":{"name":"Jornal Brasileiro De Pneumologia","volume":"51 6","pages":"e20250232"},"PeriodicalIF":3.6,"publicationDate":"2026-06-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13268511/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148264653","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of elexacaftor-tezacaftor-ivacaftor therapy on systemic inflammation in people with cystic fibrosis.","authors":"Viviane Mauro Corrêa Meyer, Natália Aranha Netto, Patricia Palmeira, Rodrigo Abensur Athanazio, Luiz Vicente Ribeiro Ferreira da Silva-Filho","doi":"10.36416/1806-3756/e20250285","DOIUrl":"10.36416/1806-3756/e20250285","url":null,"abstract":"","PeriodicalId":14845,"journal":{"name":"Jornal Brasileiro De Pneumologia","volume":"51 6","pages":"e20250285"},"PeriodicalIF":3.6,"publicationDate":"2026-06-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13268464/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148264624","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Screen time and pulmonary function in hospitalized children with cystic fibrosis.","authors":"Vanessa Dos Santos Rodrigues, Caroline Schmidt, Gleice Kelly Medeiros, Guilherme Hoff Affeldt, Bruna Ziegler","doi":"10.36416/1806-3756/e20250284","DOIUrl":"10.36416/1806-3756/e20250284","url":null,"abstract":"<p><strong>Objective: </strong>To evaluate the relationship between screen time (ST) and lung function in hospitalized children and adolescents with cystic fibrosis (CF).</p><p><strong>Methods: </strong>This was a cross-sectional study of 45 children with CF in the 0- to 17-year age bracket admitted to a public hospital in southern Brazil. ST during hospitalization was measured by means of a recall diary. Questionnaires were used in order to collect data on screen use and personal data. Data on lung function, nutrition, bacteriology, and the Shwachman-Kulczycki clinical score were obtained from patient medical records.</p><p><strong>Results: </strong>Of the study participants, 51.1% were male, with a median age of 9 years, and 80% were White. The mean FEV1 (Z-score) was -2.9 ± 1.9, and FEV1 (in % of predicted) was 63.7 ± 22.3. The median ST was 315 min, and 95.5% of the study participants exceeded the recommended ST. The most prevalent reasons for using electronic devices during hospitalization were boredom and lack of other activities. In a multivariate analysis, ST (the dependent variable) was significantly associated with age (b = 26.591; 95% CI, 14.695-38.487), time spent watching television at home (b = 0.686; 95% CI, 0.304-1.069), and FEV1 Z-score (b = -60.631; 95% CI, -115.399 to -5.864).</p><p><strong>Conclusions: </strong>Excess ST appears to be associated with worse lung function in hospitalized children with CF, as do older age and longer periods of time spent watching television at home.</p>","PeriodicalId":14845,"journal":{"name":"Jornal Brasileiro De Pneumologia","volume":"51 6","pages":"e20250284"},"PeriodicalIF":3.6,"publicationDate":"2026-06-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13268466/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148264643","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dissection of the pulmonary artery: a rare complication.","authors":"José Ricardo Bandeira de Oliveira Filho, José Fabrício Macedo, Angela Maria Pontes Bandeira de Oliveira","doi":"10.36416/1806-3756/e2025-0362","DOIUrl":"10.36416/1806-3756/e2025-0362","url":null,"abstract":"","PeriodicalId":14845,"journal":{"name":"Jornal Brasileiro De Pneumologia","volume":"51 6","pages":"e20250362"},"PeriodicalIF":3.6,"publicationDate":"2026-06-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13209827/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148264650","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diagnosis of pulmonary arterial hypertension: a statement from the Brazilian Thoracic Association.","authors":"Jose Leonidas Alves-Jr, Veronica Moreira Amado, Ricardo Amorim Correa, Frederico A F Thadeu Campos, Caio Fernandes, Eloara V M Ferreira, Marcelo B Gazzana, Marcelo Jorge Jacó Rocha, Carlos Jardim, Jaquelina S Ota-Arakaki, Virginia Pacheco Guimarães, Monica Corso Pereira, Roberta P Ramos, William Salibe-Filho, Rogerio Souza, Daniel Waetge, Rudolf K F Oliveira","doi":"10.36416/1806-3756/e20250065","DOIUrl":"10.36416/1806-3756/e20250065","url":null,"abstract":"<p><p>Pulmonary arterial hypertension (PAH) is a condition that predominantly affects the pulmonary arterial bed, leading to pulmonary vascular remodeling, progressive decrease in pulmonary arterial compliance, and increase in pulmonary vascular resistance. The symptoms of PAH are nonspecific, which often contributes to diagnostic challenges and significant delays in establishing the diagnosis. The investigation of PAH is extensive and involves thorough search for potential clinical conditions that may contribute to its development, as well as the exclusion of other causes of pulmonary hypertension. The proper hemodynamic definition of PAH requires right heart catheterization (RHC) and direct measurements of mean pulmonary artery pressure, pulmonary arterial wedge pressure, cardiac output, and pulmonary vascular resistance. Additionally, RHC allows the assessment of the severity of the disease and, in selected cases, the identification of patients with a positive pulmonary vascular vasoreactivity test. RHC also provides valuable longitudinal information for risk stratification and patient follow-up. In the current manuscript, we review the PAH diagnostic workup, including a detailed review of the most up-to-date recommendations for right RHC and patient risk stratification.</p>","PeriodicalId":14845,"journal":{"name":"Jornal Brasileiro De Pneumologia","volume":"51 6","pages":"e20250065"},"PeriodicalIF":3.6,"publicationDate":"2026-06-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13268491/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148264713","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Recognizing and managing deventilation syndrome in patients with COPD.","authors":"Inês Carvalho, Maria Jacob, Anabela Marinho","doi":"10.36416/1806-3756/e20250256","DOIUrl":"10.36416/1806-3756/e20250256","url":null,"abstract":"","PeriodicalId":14845,"journal":{"name":"Jornal Brasileiro De Pneumologia","volume":"51 6","pages":"e20250256"},"PeriodicalIF":3.6,"publicationDate":"2026-06-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13268488/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148264666","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Lung injury following butane inhalation.","authors":"Luciana Volpon Soares Souza, Arthur Soares Souza, Edson Marchiori","doi":"10.36416/1806-3756/e20250364","DOIUrl":"10.36416/1806-3756/e20250364","url":null,"abstract":"","PeriodicalId":14845,"journal":{"name":"Jornal Brasileiro De Pneumologia","volume":"51 6","pages":"e20250364"},"PeriodicalIF":3.6,"publicationDate":"2026-06-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13268463/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148264691","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Expression of angiotensin-converting enzyme 2, transmembrane serine protease 2, and sirtuin 1 proteins in lungs of different age groups.","authors":"Ana Carolina Alves Lamounier, Francisca Carla Lucas Froio, Gabriel Ribeiro Júnior, Natália de Souza Xavier Costa, Jôse Mára de Brito, Luiz Vicente Ribeiro Ferreira da Silva-Filho, Thais Mauad","doi":"10.36416/1806-3756/e20250127","DOIUrl":"10.36416/1806-3756/e20250127","url":null,"abstract":"<p><strong>Objective: </strong>Apart from the counter-regulation of angiotensin II levels in the renin-angiotensin system, angiotensin-converting enzyme 2 (ACE2) acts as a receptor for SARS-CoV-2, which is activated by transmembrane serine protease 2 (TMPRSS2) in target cells. Sirtuin 1 (SIRT1), an aging-related protein, controls ACE2 transcription in energy stress situations. This study aimed to evaluate the protein expression of ACE2, TMPRSS2, and SIRT1 in the lungs of children, adults, and elderly individuals.</p><p><strong>Methods: </strong>We used immunohistochemistry and software-assisted analysis to evaluate ACE2, TMPRSS2, and SIRT1 protein expression in autopsied lung tissue with minimal histological abnormalities and no clinical diagnosis of pulmonary disease or infection. The study population included 25 children (newborn to 19-year-old), 7 adults (20- to 59-year-old), and 11 elderly individuals (60- to 95-year-old). Of those 43 patients, 19 were female and 24 were male.</p><p><strong>Results: </strong>ACE2, TMPRSS2, and SIRT1 proteins were more expressed in the pulmonary parenchyma of children than in that of adults (p = 0.043, p = 0.008, and p = 0.032, respectively). SIRT1 expression was higher in the alveoli of children than in those of elderly patients (p = 0.008). No sex-based differences were observed. Spearman's correlation coefficient showed that ACE2, TMPRSS2, and SIRT1 expression decreased with aging.</p><p><strong>Conclusions: </strong>ACE2, TMPRSS2, and SIRT1 were more expressed in the lung parenchyma (but not in the airways) of children than in that of older individuals. This could contribute to less severe COVID-19 lung disease in children.</p>","PeriodicalId":14845,"journal":{"name":"Jornal Brasileiro De Pneumologia","volume":"51 6","pages":"e20250127"},"PeriodicalIF":3.6,"publicationDate":"2026-06-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13268514/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148264699","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}