Influence of ADRB2 variants on bronchodilator response and asthma control in a mixed population.

IF 3 4区医学 Q2 RESPIRATORY SYSTEM

Jornal Brasileiro De Pneumologia Pub Date : 2025-08-18 eCollection Date: 2025-01-01 DOI:10.36416/1806-3756/e20250066

Pedro Augusto Silva Dos Santos Rodrigues, Álvaro Augusto Souza da Cruz Filho, Helena Mariana Pitangueira Teixeira, Luciano Gama da Silva Gomes, Hatilla Dos Santos Silva, Juliana Lopes Rodrigues, Almirane Lima de Oliveira, Cinthia Vila Nova Santana, Gabriela Pimentel Pinheiro das Chagas, Camila Alexandrina Viana de Figueiredo, Ryan Dos Santos Costa

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Abstract

Objective: Given that b2 agonists constitute the primary treatment for asthma and that treatment response varies as a result of polymorphisms in the ADRB2 gene, we sought to investigate the associations between ADRB2 gene variants and bronchodilator response (BDR) in asthma patients.

Methods: A genetic database comprising 813 individuals was analyzed for variants in the ADRB2 gene. A longitudinal analysis of severe asthma patients was performed to evaluate changes in BDR over time.

Results: The rs1042713, rs1042714, and rs1042717 variants were associated with age-related changes in BDR in patients with severe asthma. The G allele (rs1042714) and the A allele (rs1042717) were associated with uncontrolled asthma, with carriers of the G46/G79/A252 alleles showing a higher risk of difficult-to-control asthma. Notably, no association was found between these variants and ADRB2 expression levels.

Conclusions: Our findings suggest that a genetic panel including ADRB2 variants, as well as age-related differences in BDR, is a useful complementary tool in asthma management.

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ADRB2变异对混合人群支气管扩张剂反应和哮喘控制的影响

鉴于b2激动剂是哮喘的主要治疗药物，而ADRB2基因的多态性会导致治疗反应的变化，我们试图研究ADRB2基因变异与哮喘患者支气管扩张剂反应（BDR）之间的关系。方法：对813例个体的ADRB2基因变异进行分析。对严重哮喘患者进行了纵向分析，以评估BDR随时间的变化。结果：rs1042713、rs1042714和rs1042717变异与重度哮喘患者BDR的年龄相关变化相关。G等位基因（rs1042714）和A等位基因（rs1042717）与哮喘不受控制相关，G46/G79/A252等位基因携带者出现难以控制哮喘的风险更高。值得注意的是，这些变异与ADRB2表达水平之间没有关联。结论：我们的研究结果表明，包括ADRB2变异以及BDR年龄相关差异在内的遗传面板是哮喘管理中有用的补充工具。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Jornal Brasileiro De Pneumologia RESPIRATORY SYSTEM-

CiteScore

3.50

自引率

14.80%

发文量

118

审稿时长

20 weeks

期刊介绍： The Brazilian Journal of Pulmonology publishes scientific articles that contribute to the improvement of knowledge in the field of the lung diseases and related areas.