Journal de mycologie medicale最新文献

{"title":"Corrigendum to “Clinical profile, antifungal susceptibility, and molecular characterization of Candida auris isolated from patients in a South Indian surgical ICU.” [J Mycol Med (2021) 101176]","authors":"S. Umamaheshwari , S.M. Neelambike , S.A. Shankarnarayan , K.S. Kumarswamy , S. Gopal , H. Prakash , S.M. Rudramurthy","doi":"10.1016/j.mycmed.2025.101552","DOIUrl":"10.1016/j.mycmed.2025.101552","url":null,"abstract":"","PeriodicalId":14824,"journal":{"name":"Journal de mycologie medicale","volume":"35 2","pages":"Article 101552"},"PeriodicalIF":2.2,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144069323","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"MP1P antigen detection in urine samples could improve the rapid screening and diagnosis of talaromycosis marneffei","authors":"Yeyang Zhang ,&nbsp;Pengle Guo ,&nbsp;Yaozu He ,&nbsp;Qinzhi Zhang ,&nbsp;Longping Yang ,&nbsp;Yingchun Ke ,&nbsp;Yu Meng ,&nbsp;Feilong Xu ,&nbsp;Xiaopin Tang ,&nbsp;Linghua Li","doi":"10.1016/j.mycmed.2025.101553","DOIUrl":"10.1016/j.mycmed.2025.101553","url":null,"abstract":"<div><h3>Background</h3><div>We evaluated <em>Talaromyces marneffei</em> mannoprotein (Mp1p) antigen in urine to create a practical, rapid diagnostic tool for early treatment and reduced mortality.</div></div><div><h3>Methodology/Principal Findings</h3><div>This prospective cross-sectional study assessed the sensitivity and specificity of Mp1p detection in urine samples from 215 AIDS patients at Guangzhou Eighth People's Hospital, enrolled between March 2022 and January 2023, using ELISA and fluorescence immunochromatography (FIC). In both the Talaromycosis and non-talaromycosis groups, most patients were male, comprising 82.5 % and 88.6 %, respectively. The median age was 42 years for the talaromycosis group and 48 years for the non-talaromycosis group. All patients were HIV-infected, with median CD4+ <em>T</em> cell counts of 47 cells/μL for talaromycosis and 187 cells/μL for non-talaromycosis. Among detection methods, ELISA showed the highest sensitivity (77.5 %, 95 % CI: 61.5–89.2 %) and specificity (97.1 %, 95 % CI: 93.5–99.1 %) for the Mp1p antigen in urine. The Positive Predictive Value (PPV), Negative Predictive Value (NPV), and kappa coefficient were 79.5 % (31/39), 94.9 % (167/176), and 0.739, respectively. The Area Under the Curve (AUC) accuracy for distinguishing patients with talaromycosis was 85.8 % (95 % CI, 76.9–94.9 %). The sensitivity, specificity, PPV, NPV, and kappa value of the Mp1p antigen (Ag) in urine following FIC were 67.5 % (95 % CI: 50.9–81.4 %), 94.9 % (95 % CI: 90.5–97.6 %), 75 % (27/36), 92.7 % (166/179), and 0.649, respectively. Combining urine Mp1p Ag ELISA with serum Mp1p Ag FIC achieved the highest specificity (96 %), PPV (82.1 %), and kappa value (0.767). In contrast, the urine Mp1p Ag ELISA and serum GM Ag pairing showed the highest sensitivity (92.5 %) and NPV (98.1 %).</div></div><div><h3>Conclusions</h3><div>Identification of the Mp1p antigen (Ag) in urine has been shown to be a reliable method for differentiating coinfections in AIDS patients, serving as a supplementary tool for early detection in clinical settings.</div></div>","PeriodicalId":14824,"journal":{"name":"Journal de mycologie medicale","volume":"35 2","pages":"Article 101553"},"PeriodicalIF":2.2,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143927434","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Voriconazole in the management of invasive pulmonary aspergillosis in patients with severe liver disease: balancing efficacy and hepatotoxicity","authors":"Caopei Zheng ,&nbsp;Xin Zhang ,&nbsp;Yingmin Ma ,&nbsp;Yulin Zhang","doi":"10.1016/j.mycmed.2025.101549","DOIUrl":"10.1016/j.mycmed.2025.101549","url":null,"abstract":"<div><div>Patients with severe liver disease (SLD) are prone to developing invasive pulmonary aspergillosis (IPA) due to immunodeficiency and microbial translocation, leading to high mortality rates. Although voriconazole is the first-line treatment for IPA, its use in patients with SLD is challenging due to the risk of hepatotoxicity. In this population, reduced hepatic blood flow and enzyme activity, compromised bile excretion, and increased intestinal permeability collectively affect voriconazole metabolism, resulting in a prolonged half-life, drug accumulation, and higher incidence of adverse events (AEs). Therapeutic drug monitoring (TDM) is essential to optimize voriconazole therapy, ensuring plasma concentrations within the therapeutic range (1.0-5.0 mg/L) while minimizing toxicity risks. This review highlights the risk factors for IPA in patients with SLD, the mechanisms of voriconazole-induced hepatotoxicity, its pharmacokinetics in this population, and current research on dose optimization. We emphasize the necessity of closely monitoring voriconazole plasma concentration, liver function, and inflammatory markers during treatment. For patients with SLD, we recommend a loading dose of 200 mg every 12 hours, with subsequent maintenance doses reduced to 1/4-1/3 of the standard dose, though the evidence remains limited. We call for large-scale clinical trials to define optimal dosing, efficacy, and safety of voriconazole for IPA in patients with SLD, providing clinicians with clearer treatment guidelines and improving patient outcomes.</div></div>","PeriodicalId":14824,"journal":{"name":"Journal de mycologie medicale","volume":"35 2","pages":"Article 101549"},"PeriodicalIF":2.2,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143844234","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Fungal Endocarditis in neonates: Case report and review of 79 cases (1983 to 2024)","authors":"Natália Daiane Garoni Martins ,&nbsp;Beatriz dos Santos Bezerra ,&nbsp;Cinthya Alves Esteves ,&nbsp;Luana Rossato","doi":"10.1016/j.mycmed.2025.101542","DOIUrl":"10.1016/j.mycmed.2025.101542","url":null,"abstract":"<div><h3>Purpose</h3><div>Fungal endocarditis in neonates poses a significant clinical challenge, with limited comprehensive data available. The aim of this study was describe a case report and further characterize demographic and clinical aspects of fungal endocarditis in neonates.</div></div><div><h3>Methods</h3><div>We present, a case report of a very low birth weight infant with fungal endocarditis. We also conducted a thorough analysis of 79 documented clinical cases, exploring demographics, clinical characteristics, treatment strategies, and outcomes.</div></div><div><h3>Results</h3><div>The temporal distribution revealed varied trends over the years. The United States had the highest case count, followed by India, Turkey, and Israel. Prematurity was predominant, with extremely low birth weight neonates being most affected. Congenital malformations were present in 10.2 % of cases. Surgical interventions, particularly for vegetative mass removal, were common. <em>Candida albicans</em> was the primary pathogen, followed by <em>Candida parapsilosis</em>. Catheter use was strongly associated with the majority of cases. The overall mortality rate was 38 %. Higher mortality was observed in neonates receiving monotherapy compared to those on combination therapy. Mortality was also significantly higher in neonates with prior bacteremia or fungemia and in those receiving antibiotic therapy without confirmed bacteremia. Conversely, postoperative mortality associated with surgery was 36.4 %, slightly lower than the overall mortality rate, suggesting that surgery may not represent an increased risk.</div></div><div><h3>Conclusion</h3><div>Our study provides comprehensive insights into fungal endocarditis in neonates, highlighting the need for tailored management strategies to improve outcomes.</div></div>","PeriodicalId":14824,"journal":{"name":"Journal de mycologie medicale","volume":"35 2","pages":"Article 101542"},"PeriodicalIF":2.2,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143746398","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cerebellar abscess caused by Cladophialophora bantiana involving an elderly Japanese woman","authors":"Kenta Nakamoto ,&nbsp;Hideharu Hagiya ,&nbsp;Shinnosuke Fukushima ,&nbsp;Kohei Oguni ,&nbsp;Yukika Yokoyama ,&nbsp;Koji Iio ,&nbsp;Shuichiro Hirano ,&nbsp;Takashi Yaguchi ,&nbsp;Sayaka Ban ,&nbsp;Akira Watanabe ,&nbsp;Hiroki Okunobu ,&nbsp;Atsuhito Suyama ,&nbsp;Marina Kawaguchi ,&nbsp;Yousuke Sazumi ,&nbsp;Fumio Otsuka","doi":"10.1016/j.mycmed.2025.101548","DOIUrl":"10.1016/j.mycmed.2025.101548","url":null,"abstract":"<div><div>Phaeohyphomycosis is a rare fungal infection that presents significant challenges in diagnosis and treatment. Herein, we document a case of a cerebellar abscess caused by Cladophialophora bantiana. A 77-year-old woman with type 2 diabetes mellitus and a previous history of diffuse large B-cell lymphoma gradually developed ataxia and was transferred to an emergency department. Head imaging investigations indicated a cerebellar mass and the patient underwent an emergent endoscopic drainage. Although bacterial cultures of the drainage specimen yielded no growth, a dematiaceous fungus was isolated and subsequently identified as C. bantiana <em>through ITS sequencing analysis. The patient received antifungal combination therapy, initially with</em> liposomal amphotericin B and voriconazole, and finally posaconazole and 5-fluorocytosine. Brain abscesses caused by C. bantiana are rarely documented, and an optimal treatment strategy has yet to be established. Given the high fatality rate, an early surgical intervention is crucial for both diagnosis and treatment. The present case was successfully treated with minimally invasive surgical intervention alongside the antifungal combination therapy.</div></div>","PeriodicalId":14824,"journal":{"name":"Journal de mycologie medicale","volume":"35 2","pages":"Article 101548"},"PeriodicalIF":2.2,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143737803","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The first autochthonous human case of sporotrichosis by Sporothrix brasiliensis in Paraguay","authors":"Mirtha Gabriela Santacruz Silvero ,&nbsp;Carolina Melchior do Prado ,&nbsp;Bram Spruijtenburg ,&nbsp;Federico Augusto Lacarrubba Codas ,&nbsp;Maria Leticia Ojeda ,&nbsp;Bruna Jacomel Favoreto de Souza Lima ,&nbsp;Nancy Segovia Coronel ,&nbsp;José Pereira Brunelli ,&nbsp;Vânia Aparecida Vicente ,&nbsp;Theun de Groot ,&nbsp;Flávio Queiroz-Telles ,&nbsp;Eelco F.J. Meijer","doi":"10.1016/j.mycmed.2025.101536","DOIUrl":"10.1016/j.mycmed.2025.101536","url":null,"abstract":"<div><div>Sporotrichosis by <em>Sporothrix brasiliensis</em> is increasingly reported in South America. Here, we present the first autochthonous human case in Paraguay, transmitted by a local infected cat. After 63 days of clinical signs onset, the patient was correctly diagnosed and antifungal treatment started, highlighting the need to increase awareness for this emerging disease.</div></div>","PeriodicalId":14824,"journal":{"name":"Journal de mycologie medicale","volume":"35 1","pages":"Article 101536"},"PeriodicalIF":2.2,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143350634","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Biliary diffusion and antifungal activity of caspofungin and fluconazole in liver transplant recipients: A pilot study","authors":"Cécile Garnaud ,&nbsp;Thibaut Gelé ,&nbsp;Elodie Gautier-Veyret ,&nbsp;Agnès Bonadona ,&nbsp;Thomas Lefebvre ,&nbsp;Christelle Boglione-Kerrien ,&nbsp;Françoise Stanke-Labesque ,&nbsp;Jean-Pierre Gangneux ,&nbsp;Françoise Botterel ,&nbsp;Anne Hulin ,&nbsp;Muriel Cornet","doi":"10.1016/j.mycmed.2024.101531","DOIUrl":"10.1016/j.mycmed.2024.101531","url":null,"abstract":"<div><div>Invasive candidiasis, including intra-abdominal candidiasis (IAC), is a common complication after liver transplantation. Antifungal drugs such as echinocandins and fluconazole (FCZ) are frequently used to prevent or treat such fungal infections. The diffusion of these antifungals within abdominal body sites has been rarely reported, in particular, in liver transplant recipients. This study aimed to evaluate the biliary diffusion of caspofungin (CAS) and FCZ. CAS and FCZ concentrations were determined in plasma and bile using a validated liquid chromatography-mass spectrometry method. Biliary concentrations of CAS (<em>n</em> = 5) and FCZ (<em>n</em> = 12) ranged from 1.6 to 4.4 and 6.4 to 33.4 mg/L, respectively, with respective medians of 1.9 and 17.7 mg/L. These values are higher than the MICs for yeast species frequently involved in IAC, suggesting that such antifungal exposure is sufficient to prevent/cure these infections. However, yeast was found in bile collected during CAS treatment from 3/5 patients, raising questions about the effective antifungal activity of this echinocandin at this anatomical site. Our pilot study shows that CAS and FCZ diffuse to the bile of liver transplant recipients. However, whether the observed antifungal concentrations are sufficiently high to prevent/cure IAC remains an unanswered question</div></div>","PeriodicalId":14824,"journal":{"name":"Journal de mycologie medicale","volume":"35 1","pages":"Article 101531"},"PeriodicalIF":2.2,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142965014","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Thymol inhibits ergosterol biosynthesis in Nakaseomyces glabratus, but differently from azole antifungals","authors":"Fatemeh Asmiteh ,&nbsp;Milad Lagzian ,&nbsp;Reza Valadan ,&nbsp;Mahdi Abastabar ,&nbsp;Tahereh Shokohi ,&nbsp;Mohammad taghi Hedayati ,&nbsp;Shima Parsay ,&nbsp;Abolfazl Saravani ,&nbsp;Maryam Moazeni","doi":"10.1016/j.mycmed.2024.101530","DOIUrl":"10.1016/j.mycmed.2024.101530","url":null,"abstract":"<div><h3>Introduction</h3><div><em>Nakaseomyces glabratus</em> is considered a high priority of attention according to WHO, and also is an important yeast species due to its high rate of intrinsic/acquired resistance against fluconazole. This study aimed at the possible mechanisms of action of thymol, as the promising new antifungal agent, in <em>N. glabratus.</em></div></div><div><h3>Methods</h3><div>Thirty previously identified <em>N. glabratus</em> isolates were selected for investigation of the thymol susceptibility pattern. The antifungal susceptibility test was performed according to the Clinical and Laboratory Standards protocol published as M27-A2 document. Likely changes in the expression pattern of genes involved in the ergosterol biosynthesis pathway were assessed by Real-time PCR assay. The ultrastructure characteristics of thymol-treated yeasts and also the possible interactive proteins, as targets for thymol binding, were performed by transmission electron microscopy (TEM) and reverse molecular docking, respectively.</div></div><div><h3>Results</h3><div>Minimum inhibitory concentrations ranged between 32–128 µg/mL which were statistically significant between the fluconazole-susceptible and fluconazole-resistant yeast group (P&lt;0. 05). TEM observation results showed that thymol led to peripheral vacuole formation which refers to plasma membrane damage and cell membrane separation from the cell wall. Thymol exhibits antifungal activity against <em>N. glabratus</em> by regulating multiple signaling pathways including ergosterol biosynthesis (<em>ERG1</em>) and <em>HOG</em> (high-osmolarity glycerol) MAPK (mitogen-activated protein kinase) pathways. In consistence with the yielded gene expression patterns, docking evaluation findings also revealed the high affinity of thymol with proteins related to the <em>ERG1</em> gene. Accordingly, thymol's high affinity to chitin synthase and calcineurin subunit B was noteworthy.</div></div><div><h3>Conclusion</h3><div>Thymol might employ its antifungal effect by involving different pathways comprising ergosterol biosynthesis inhibition but not identical to the azole drugs. It is highly suggested that thymol ruins cell membrane function by decreasing the ergosterol/or chitin content. However, studying more ergosterol biosynthesis-related genes and also the yeast apoptotic responses is highly recommended for future investigations.</div></div>","PeriodicalId":14824,"journal":{"name":"Journal de mycologie medicale","volume":"35 1","pages":"Article 101530"},"PeriodicalIF":2.2,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143005732","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Investigation of a dermatophytosis outbreak in a kindergarten in Doubs, France, June 2022","authors":"Sabrina Tessier ,&nbsp;Dominique Cailly ,&nbsp;Anne-Pauline Bellanger ,&nbsp;Emeline Scherer ,&nbsp;Isabelle Lucot ,&nbsp;Lauriane Szpakowski-Perrot ,&nbsp;Rachel Daveau ,&nbsp;Camille Chapulliot ,&nbsp;Evelyne Simon-Rose ,&nbsp;Antoine Journé ,&nbsp;Mélina Renard ,&nbsp;Nadia Gharet ,&nbsp;François Clinard ,&nbsp;Marie Barba-Vasseur","doi":"10.1016/j.mycmed.2025.101537","DOIUrl":"10.1016/j.mycmed.2025.101537","url":null,"abstract":"<div><h3>Background</h3><div><em>Microsporum audouinii</em>, an anthropophilic dermatophyte has recently reemerged in several European countries (such as France).</div></div><div><h3>Aim</h3><div>To describe the epidemiological and microbiological investigations into several reported cases of dermatophytosis to the public health authorities in May 2022 in a kindergarten in the Doubs department (eastern France).</div></div><div><h3>Methods</h3><div>All children with clinical signs underwent a clinical examination and mycological investigation of skin or scalp samples taken onsite at the kindergarten. Several diagnosis methods were used: Wood's lamp examination, classical process (direct examination associated to culture) and molecular techniques. An epidemiological survey by questionnaire was also performed to collect individual exposure data.</div></div><div><h3>Results</h3><div>Fifteen children presented lesions during the clinical examination. Therapy was prescribed for nine children based on the 2021 recommendations of the French Society of Dermatology. <em>Microsporum canis</em> was initially diagnosed by the classical process. This identification was not confirmed by epidemiological information (absence of direct contact with animals) and molecular techniques. Finally, <em>Microsporum audouinii</em> was isolated in six children (two positive Wood's lamp examinations) and one staff member.</div></div><div><h3>Conclusion</h3><div>Species identification allowed us to (1) update the therapeutic strategy (all children were treated successfully) and (2) be more vigilant regarding the risk of human-to-human transmissions. The management of intrafamilial transmissions requires collaboration with healthcare practitioners to clinically examine family members, prescribe laboratory investigations, and reiterate the hygiene measures. This study confirmed the importance of combining field epidemiological investigations and microbiological examinations when managing dermatophytosis outbreaks.</div></div>","PeriodicalId":14824,"journal":{"name":"Journal de mycologie medicale","volume":"35 1","pages":"Article 101537"},"PeriodicalIF":2.2,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143394391","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Species distribution and antifungal susceptibility patterns of Candida involvement in pediatric solid organ transplant recipients: A cross-sectional study from a single transplant center","authors":"Somayeh Yazdanpanah ,&nbsp;Mojtaba Shafiekhani ,&nbsp;Zahra Zare ,&nbsp;Hamed Nikoupour ,&nbsp;Bita Geramizadeh ,&nbsp;Parisa Chamanpara ,&nbsp;Ahmad Jabrodini ,&nbsp;Mohammad Ahmadi ,&nbsp;Zahra Malekizadeh ,&nbsp;Mohammad Hossein Anbardar ,&nbsp;Keyvan Pakshir ,&nbsp;Kamiar Zomorodian","doi":"10.1016/j.mycmed.2024.101522","DOIUrl":"10.1016/j.mycmed.2024.101522","url":null,"abstract":"<div><div>The epidemiology and resistance patterns of <em>Candida</em> infections in pediatric kidney/liver recipients has not been well characterized, recently. In this study, all patients ≤ 18 years old who underwent liver/kidney transplant surgery between September 2021 and 2022 were included. Species identification of isolates recovered from clinical specimens was performed by DNA-sequencing method following amplification of the ITS1–5.8S–ITS2 regions. Antifungal susceptibility patterns of isolates were performed using the micro broth dilution method documented by Clinical &amp; Laboratory Standards Institute (CLSI) guidelines. Of the 117 pediatric recipients enrolled, 16 recipients (13.7 %) had at least one positive <em>Candida</em> culture. Candidemia was detected in 5/89 (5.6 %) of liver and 1/28 (3.6 %) of kidney transplant recipients. Invasive candidiasis was observed in 6/89 (6.7 %) of liver and 2/28 (7.1 %) of kidney transplant recipients. The predominant species was <em>Candida</em> (<em>C</em>.) <em>albicans</em> recovered from 12 of 16 recipients (75 %). In addition to the <em>Pichia kudriavzevii</em> species with inherent resistance to fluconazole, one of <em>C. albicans</em> isolates and one <em>C. tropicalis</em> isolate were also identified as fluconazole-resistant (3/29:10.3 %). Moreover, our findings revealed 13.8 % and 6.8 % resistance to itraconazole and voriconazole, respectively. All <em>Candida</em> spp. were susceptible to caspofungin. Collectively, this study provides valuable insights into the epidemiology and resistance patterns of <em>Candida</em> infections in pediatric kidney and liver recipients. The study also highlights the emergence of fluconazole-resistant strains, which has significant implications for antifungal stewardship efforts in pediatric transplant populations.</div></div>","PeriodicalId":14824,"journal":{"name":"Journal de mycologie medicale","volume":"35 1","pages":"Article 101522"},"PeriodicalIF":2.2,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142780259","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}