Journal de mycologie medicale最新文献

{"title":"A one health perspective on Diutina catenulata: Phenotypic traits, stress sensitivity, and virulence across diverse isolates","authors":"Ianca Karine Prudencio de Albuquerque ,&nbsp;Florent Morio ,&nbsp;Marjorie Albassier ,&nbsp;Luc Baron ,&nbsp;Léa Duchesne ,&nbsp;Patrice Le Pape ,&nbsp;Isabelle Ourliac-Garnier","doi":"10.1016/j.mycmed.2025.101583","DOIUrl":"10.1016/j.mycmed.2025.101583","url":null,"abstract":"<div><div><em>Diutina catenulata</em>, formerly <em>Candida catenulata</em>, is found in diverse substrates, including soil, food, animals, and humans. It is recognized as an emerging human pathogen responsible for various diseases, including invasive infections in susceptible hosts, particularly in immunocompromised individuals. This study aimed to assess the phenotypic profiles, <em>in vitro</em> responses to various stressful conditions, and <em>in vivo</em> virulence of <em>D. catenulata</em> isolates from different origins (human, veterinary, and environmental). <em>In vitro</em> antifungal susceptibility to fluconazole, voriconazole, micafungin and amphotericin B was also determined for all isolates. Most <em>D. catenulata</em> isolates exhibited a light blue coloration on CHROMID® <em>Candida</em> agar. Different profiles were observed on the Spider medium, suggesting different behavior among the isolates. All isolates of <em>D. catenulata</em> were highly sensitive to oxidative and osmotic stress as demonstrated by exposure to H₂O₂ and 1.5 M NaCl, respectively whereas no unique pattern was evidenced concerning the response to cell wall stressors or membrane stressors. In addition to acquired azole resistance for some isolates, these findings provide valuable insights into the strain-dependent responses of <em>D. catenulata</em> to various stress factors. Using <em>Galleria mellonella,</em> we highlighted a wide range of virulence profiles among the isolates. Overall, this research demonstrates that the observed responses are strain-dependent rather than sample-source-dependent.</div></div>","PeriodicalId":14824,"journal":{"name":"Journal de mycologie medicale","volume":"35 4","pages":"Article 101583"},"PeriodicalIF":1.8,"publicationDate":"2025-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145212830","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Tinea capitis in adults: A 14-year retrospective study in central Tunisia","authors":"Hamed Chouaieb ,&nbsp;Mohammad Akhoundi ,&nbsp;Nadia Ghariani Fetoui ,&nbsp;Yasmine Kalboussi ,&nbsp;Samar Ismail ,&nbsp;Imen Khammari ,&nbsp;Sophie Brun ,&nbsp;Mohamed Denguezli ,&nbsp;Akila Fathallah","doi":"10.1016/j.mycmed.2025.101582","DOIUrl":"10.1016/j.mycmed.2025.101582","url":null,"abstract":"<div><h3>Objectives</h3><div>Tinea capitis (TC) is a common fungal infection predominantly affecting school-aged children while being rare among adults. Few studies, particularly in Tunisia, have specifically focused on TC in adults. This retrospective study aimed to assess the epidemiological and mycological profile of adult TC in central Tunisia (North Africa).</div></div><div><h3>Methods</h3><div>A retrospective study of adult TC cases diagnosed at the Farhat Hached University Hospital of Sousse, in Tunisia, has been carried out over a 14-year period (2009–2022). Diagnosis was based on clinical presentation and mycological culture. Of 3711 patients examined, 41 adult patients (24 women and 17 men) were diagnosed with TC. The mean age was 43 years old. Ten patients had a history of corticosteroid therapy. Physical examination revealed associated tinea corporis in 6 cases (14.6 %), onychomycosis in 10 cases (24 %) and both those conditions concomitantly in one patient (2.4 %). Direct examination was positive in 97.5 % of cases. The most prevalent species of dermatophyte were <em>Trichophyton violaceum</em> (46 %) and <em>Microsporum canis</em> (34 %). In the majority of cases, the course of treatment was favorable.</div></div><div><h3>Conclusion</h3><div>We highlight TC as an uncommon condition in adults, with a higher prevalence observed in women, particularly postmenopausal women. Adult TC, though uncommon, should be considered in differential diagnoses for scalp lesions in elderly patients due to potential atypical presentations. <em>Trichophyton violaceum</em> is the most frequent species in central Tunisia. Accurate mycological diagnosis and identification of contributing factors remain crucial.</div></div>","PeriodicalId":14824,"journal":{"name":"Journal de mycologie medicale","volume":"35 4","pages":"Article 101582"},"PeriodicalIF":1.8,"publicationDate":"2025-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145148637","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Disseminated histoplasmosis in erythematosus systemic lupus: A case report and review","authors":"Carlos Solórzano,&nbsp;Johiner Vanegas,&nbsp;Maria Alejandra Caro,&nbsp;Maria Camila Rubio","doi":"10.1016/j.mycmed.2025.101581","DOIUrl":"10.1016/j.mycmed.2025.101581","url":null,"abstract":"<div><div>Histoplasmosis is an endemic mycosis in some regions affecting particularly immunosuppressed individuals. The global prevalence of disseminated histoplasmosis in systemic lupus erythematosus (SLE) patients is &lt;1 %, but rises in endemic areas such as Colombia. Clinical manifestations in those patients are atypical, ranging from non-specific symptoms to severe cases of multi-organ failure. Given its rarity and the nonspecific nature of its symptoms, disseminated histoplasmosis in the context of systemic lupus erythematosus remains a diagnostic challenge.</div><div>A 28-year-old female patient with a history of SLE diagnosed in 2009 presented to our clinic in February 2024. The patient reported an acute onset of non-specific symptoms, with a subsequent treatment for a suspected bacterial lung infection and successfully discharged. However, due to persistent fever and ongoing weight loss, she returned for further evaluation. Initially a thoracic computed tomography and fiberoptic bronchoscopy was performed, with negative results for tuberculosis (TB), however TB treatment was empirically initiated according to imagenological findings. During hospitalization, the patient developed gastrointestinal bleeding, prompting further investigations and confirming <em>Histoplasma capsulatum</em> in a biopsy. Despite the antifungal therapy, the patient’s condition deteriorated, culminating in multiorgan failure and death 10 days later.</div><div>This case underscores the importance of prompt and accurate diagnosis of disseminated histoplasmosis in patients with SLE. The clinical presentation can mimic a lupus flare or other infectious diseases, potentially delaying the initiation of appropriate therapy. In endemic regions such as Latin America, it is critical to include disseminated histoplasmosis in the differential diagnosis of febrile illness in immunosuppressed patients.</div></div>","PeriodicalId":14824,"journal":{"name":"Journal de mycologie medicale","volume":"35 4","pages":"Article 101581"},"PeriodicalIF":1.8,"publicationDate":"2025-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145045653","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Novel antifungal activity of broxyquinoline against ITC-Resistant mutants via inhibition of methionine aminopeptidase in Aspergillus fumigatus","authors":"Peiying Chen ,&nbsp;Siyuan Tao ,&nbsp;Simin Xu ,&nbsp;Yangyang Yong ,&nbsp;Fei Gao ,&nbsp;Yuan Chen ,&nbsp;Chujie Lu ,&nbsp;Wei Lin","doi":"10.1016/j.mycmed.2025.101577","DOIUrl":"10.1016/j.mycmed.2025.101577","url":null,"abstract":"<div><h3>Background</h3><div>A rising public health threat of invasive aspergillosis causing by azole-resistant <em>Aspergillus</em> species necessitates the development of novel antifungal agents. We performed a screening of antifungal compounds against azole-resistant fungi and broxyquinoline was identified. Our aim was to investigate its antifungal activities and antifungal mechanism.</div></div><div><h3>Methods</h3><div>Fungal susceptibility testing for broxyquinoline carried out by the broth-based microdilution methods. Cell viability treated by broxyquinoline was tested by resazurin dye testing. The synergistic effect of broxyquinoline and itraconazole was evaluated using checkboard assay. Enzyme activity was investigated with spectrophotometric methods. The key amino acid residues in the binding of broxyquinoline with <em>A. fumigatus</em> methionine aminopeptidase (<em>Af</em>MetAP) were indicated by structural analyses, site-directed mutagenesis, and microscale thermophoresis (MST) assays.</div></div><div><h3>Results</h3><div>Broxyquinoline has fungicidal activity against azole-resistant <em>A. fumigatus</em> and synergistic effects with itraconazole. Moreover, we discovered that broxyquinoline is strong inhibitor of <em>Af</em>MetAP through interacting with key residues T279A/W280A of <em>Af</em>MetAP1 and Y527A of <em>Af</em>MetAP2, and <em>in vivo,</em> the strains with high expression of <em>Af</em>MetAP are resistant to BQ.</div></div><div><h3>Conclusions</h3><div>Broxyquinoline has antifungal activities against azole-resistant <em>Aspergillus</em> spp. and is also a potentiator of ITC <em>in vitro. Af</em>MetAP may biologically targets to BQ <em>in vivo</em> regulating antifungal activity. T279A/W280A of <em>Af</em>MetAP1 and Y527A of <em>Af</em>MetAP2 are key amino acid sites to maintain stable interactions between broxyquinoline and target enzymes <em>Af</em>MetAP.</div></div>","PeriodicalId":14824,"journal":{"name":"Journal de mycologie medicale","volume":"35 4","pages":"Article 101577"},"PeriodicalIF":1.8,"publicationDate":"2025-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145060681","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Terbinafine-resistant Trichophyton indotineae in two Italian MSM: a new emerging sexually transmissible infection","authors":"Luigi Pisano ,&nbsp;Deborah Cruciani ,&nbsp;Silvia Crotti ,&nbsp;Manuela Papini","doi":"10.1016/j.mycmed.2025.101578","DOIUrl":"10.1016/j.mycmed.2025.101578","url":null,"abstract":"<div><div>We report, to the best of our knowledge, the first two cases of <em>Trichophyton (T.) indotineae</em> infection observed in a couple of Italian engaged men who have sex with men (MSM), potentially acquired through sexual contact with a third man from India.</div><div>This article also provides a narrative review of the most recent existing literature on the potential sexual transmission of genital dermatophytoses. For dermatophytosis sexual transmission is a presumptive diagnosis but some clinical criteria may raise suspicion of sexual transmission, such as the occurrence of genital lesions in individuals with high-risk sexual behavior, without simultaneous involvement of the feet and/or nails, without a history of contact with infected animals, and the presence of similar lesions in sexual partners.</div><div>In recent years, several reports have indicated a potential sexual transmission of genital dermatophytosis, mainly caused by <em>T. mentagrophytes</em> genotype VII (TMVII), first observed in heterosexual individuals and then also in groups of MSM, suggesting a potentially unnoticed epidemic at the European level. From 2020 onwards, the emergence of <em>T. indotineae</em>, a novel strain closely related to TMVII, yet often associated with Terbinafine resistance, has been documented in more than 30 countries worldwide. Laboratory identification requires advanced molecular techniques, as culture-based methods are unable to differentiate <em>T. indotineae</em> from other <em>Trichophyton</em> species. A proper species-level diagnosis is essential to establish the appropriate treatment. Dermatologists should be aware of the international spread of this new strain and its potential sexual transmission and conduct targeted mycological tests in at-risk populations.</div></div>","PeriodicalId":14824,"journal":{"name":"Journal de mycologie medicale","volume":"35 4","pages":"Article 101578"},"PeriodicalIF":1.8,"publicationDate":"2025-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145045651","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Performance of recombinase polymerase amplification-based assay (RPA) for rapid detection of fungal pathogens in clinical samples of patients in Abidjan, Côte d’Ivoire","authors":"David Koffi ,&nbsp;Francis K. Kouadjo ,&nbsp;Stephane T. Koui ,&nbsp;Kader Diarrassouba ,&nbsp;Benjamin Djedji ,&nbsp;Jon Salmanton-García ,&nbsp;Valerie Ira-Bonouman ,&nbsp;Joseph A. Djaman ,&nbsp;Andre O. Toure","doi":"10.1016/j.mycmed.2025.101579","DOIUrl":"10.1016/j.mycmed.2025.101579","url":null,"abstract":"<div><h3>Background</h3><div>The diversity of fungal species involved in medical mycology and the increasing rates of resistances make antifungal therapy increasingly challenging. A strategic approach aims to prevent the spread of resistant fungal pathogens and address the prolonged culture time required for fungal identification. The identification of microscopic fungi in biological samples has gained growing interest in molecular biology. The promising isothermal amplification technique can overcome the shortcomings of conventional methods by offering a short reaction time, as well as high specificity and sensitivity.</div></div><div><h3>Objective</h3><div>This study was initiated to develop a rapid method for identifying fungi from patient biological samples.</div></div><div><h3>Materials.and.Methods</h3><div>Ninety biological samples were collected from patients and various anatomical sites. The samples were cultured, and DNA extraction was performed on the isolates and biological products. The obtained DNA was used for amplification via RPA (Recombinase Polymerase Amplification).</div></div><div><h3>Results</h3><div>The results demonstrated varying sensitivity and specificity depending on the type of biological sample, with high sensitivity and specificity for mucosal samples (100 %, respectively), followed by those of invasive mycoses (80 % and 67 %, respectively), and superficial mycoses (72 % sensitivity).</div></div><div><h3>Conclusion</h3><div>The overall sensitivity and specificity of the RPA method across all sample types were elevated, with 92 % and 100 %, respectively.</div></div>","PeriodicalId":14824,"journal":{"name":"Journal de mycologie medicale","volume":"35 4","pages":"Article 101579"},"PeriodicalIF":1.8,"publicationDate":"2025-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145045652","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Metabolic immune regulation of macrophages by melanized fungus Fonsecaea monophora.","authors":"Qinling Pan, Tengteng Xin, Jing Zhang, Li Lin, Junmin Zhang","doi":"10.1016/j.mycmed.2025.101571","DOIUrl":"10.1016/j.mycmed.2025.101571","url":null,"abstract":"<p><strong>Background: </strong>Glucose metabolism in the host is crucial during microbial infections. Here, we evaluated the effects of Fonsecaea monophora (F. monophora) wild strain and the pigment-knockout strain ΔpksA mutant on glucose metabolism and immune response of macrophages.</p><p><strong>Methods: </strong>Glucose consumption, lactate secretion, genes related to glucose metabolism, and pro-inflammatory cytokines were measured in mouse macrophage J774A.1 cells infected with F. monophora wild strain or ΔpksA. Notably, 2-deoxy-d-glucose (2-DG) and metformin (Glucophage) were used to inhibit glucose metabolism in macrophages.</p><p><strong>Results: </strong>The F. monophora wild strain significantly inhibited the glucose consumption level of macrophages or classically activated macrophages, and significantly inhibited the mRNA and protein levels of the tricarboxylic acid cycle gene IDH1 in macrophages. F. monophora wild strain inhibited the expression of the pro-inflammatory cytokine IL-1β in macrophages, and upregulated the expression of TNF and IL-6. Inhibition of glucose metabolism by 2-DG or metformin (Glucophage) affected the immune response of macrophages to F. monophora wild strain. The production of IL-1β in macrophages was significantly downregulated. Compared with the control group, ΔpksA did not change glucose utilization and IDH1 expression in macrophages. F. monophora wild strain inhibited IL-1β expression in macrophages, while ΔpksA promoted it.</p><p><strong>Conclusion: </strong>Our results suggest that F. monophora wild strain reduces IL-1β expression by inhibiting the IDH1-related tricarboxylic acid cycle in macrophages. F. monophora melanin is a fungal virulence factor that inhibits glucose metabolism and regulates the immune response of macrophages.</p>","PeriodicalId":14824,"journal":{"name":"Journal de mycologie medicale","volume":"35 3","pages":"101571"},"PeriodicalIF":1.8,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144812018","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bone marrow cryptococcosis in an HIV-infected patient: A case report and literature review","authors":"Sirine Chtourou ,&nbsp;Fatma Hammami ,&nbsp;Amal Chakroun ,&nbsp;Ons Boudawara ,&nbsp;Tahia Boudawara ,&nbsp;Makram Koubaa ,&nbsp;Mounir Ben Jemaa","doi":"10.1016/j.mycmed.2025.101572","DOIUrl":"10.1016/j.mycmed.2025.101572","url":null,"abstract":"<div><h3>Background and Purpose</h3><div>Cryptococcosis is a common opportunistic fungal infection in immunocompromised individuals. It is typically isolated from cerebrospinal fluid, sputum, or skin lesions. However, disseminated cryptococcosis involving the bone marrow is an extremely rare occurrence.</div></div><div><h3>Case Report</h3><div>This case describes a 34-year-old male patient living with HIV who developed fever, abdominal pain, and pancytopenia. Diagnostic evaluation, including bone marrow aspiration and biopsy, revealed encapsulated yeasts consistent with <em>Cryptococcus</em> sp. Although blood and cerebrospinal fluid cultures failed to identify fungal agents, the diagnosis of isolated bone marrow cryptococcosis was confirmed. A literature review of 21 previously reported cases (up to October 2024) was conducted, revealing a predominance of immunocompromised patients, with male patients being more frequently affected. Cytopenia was a common finding in all cases, and bone marrow biopsy was essential for diagnosis. Treatment protocols remain unstandardized.</div></div><div><h3>Conclusion</h3><div>Bone marrow cryptococcosis, while rare, should be considered in the differential diagnosis of pancytopenia in immunocompromised patients, particularly those with HIV.</div></div>","PeriodicalId":14824,"journal":{"name":"Journal de mycologie medicale","volume":"35 4","pages":"Article 101572"},"PeriodicalIF":1.8,"publicationDate":"2025-08-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144918136","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Beyond the lungs: a case report of disseminated cutaneous aspergillosis highlighting clinical dilemmas in invasive fungal infections of critically ill patients","authors":"Yao Xu,&nbsp;Jiansan He,&nbsp;Peng Jin,&nbsp;Mingming Fei,&nbsp;Shaohui Cheng","doi":"10.1016/j.mycmed.2025.101573","DOIUrl":"10.1016/j.mycmed.2025.101573","url":null,"abstract":"<div><div>With opportunistic fungal pathogens increasingly recognized as a global public health threat, the population at high risk for invasive fungal infections (IFIs) has expanded beyond traditionally immunocompromised individuals—such as those with malignancies, organ transplantation, diabetes mellitus, or acquired immunodeficiency syndrome (AIDS)—to include critically ill patients in intensive care units (ICUs) receiving invasive support and immunomodulatory therapies. Invasive aspergillosis (IA) is one of the most lethal opportunistic infections in this population, characterized by insidious onset, clinical heterogeneity, and a lack of specific signs, often resulting in delayed diagnosis. Disseminated or breakthrough aspergillosis carries an exceedingly high mortality rate. We report the case of a female patient admitted to the ICU with fulminant myocarditis who required extracorporeal membrane oxygenation (ECMO), continuous renal replacement therapy (CRRT), and immunomodulation. Her hospitalization was complicated by a progressive pulmonary infection, and metagenomic next-generation sequencing (mNGS) of respiratory specimens identified <em>Candida albicans, Aspergillus</em> spp. and <em>Staphylococcus hominis</em>, prompting an adjustment in antimicrobial therapy. Subsequently, the patient developed multiple cutaneous nodules, which tissue biopsy and mNGS confirmed as invasive cutaneous aspergillosis. Despite aggressive antifungal treatment with isavuconazole and amphotericin B, her condition deteriorated rapidly, leading to disseminated cutaneous necrosis, irreversible septic shock and multiorgan failure. This case highlights the clinical importance of recognizing atypical IFI presentations. Heightened clinical suspicion for disseminated fungal disease is warranted in critically ill patients with extrapulmonary lesions. Prompt microbiological diagnosis and antifungal resistance surveillance are essential for effective antifungal therapy.</div></div>","PeriodicalId":14824,"journal":{"name":"Journal de mycologie medicale","volume":"35 4","pages":"Article 101573"},"PeriodicalIF":1.8,"publicationDate":"2025-08-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144907612","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Aspergillus fumigatus lung abscess in two adolescents with cystic fibrosis","authors":"Maria Noni ,&nbsp;Anna Katelari ,&nbsp;Konstantinos Iosifidis ,&nbsp;Christina Kanaka-Gantenbein ,&nbsp;Aristea Velegraki ,&nbsp;Georgia Papaioannou ,&nbsp;Stavros-Eleftherios Doudounakis","doi":"10.1016/j.mycmed.2025.101570","DOIUrl":"10.1016/j.mycmed.2025.101570","url":null,"abstract":"<div><div>Lung abscess is a severe but rare complication among non-transplanted cystic fibrosis (CF) patients. &lt;10 cases have been reported in the international literature so far and bacteria were considered the responsible pathogen. We present two cases of CF adolescent patients who developed lung abscess from <em>A. fumigatus</em>, critically revealed with chest Computed Tomography. In one patient, a thyroid abscess was additionally detected. Both patients presented with fever, not responding to antibiotic therapy. Microbial cultures and molecular testing aided detection of the pathogen. Both patients responded well to antifungal treatment.</div></div>","PeriodicalId":14824,"journal":{"name":"Journal de mycologie medicale","volume":"35 3","pages":"Article 101570"},"PeriodicalIF":2.2,"publicationDate":"2025-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144581379","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}