Journal de mycologie medicale最新文献

{"title":"Aspergillus fumigatus lung abscess in two adolescents with cystic fibrosis","authors":"Maria Noni ,&nbsp;Anna Katelari ,&nbsp;Konstantinos Iosifidis ,&nbsp;Christina Kanaka-Gantenbein ,&nbsp;Aristea Velegraki ,&nbsp;Georgia Papaioannou ,&nbsp;Stavros-Eleftherios Doudounakis","doi":"10.1016/j.mycmed.2025.101570","DOIUrl":"10.1016/j.mycmed.2025.101570","url":null,"abstract":"<div><div>Lung abscess is a severe but rare complication among non-transplanted cystic fibrosis (CF) patients. &lt;10 cases have been reported in the international literature so far and bacteria were considered the responsible pathogen. We present two cases of CF adolescent patients who developed lung abscess from <em>A. fumigatus</em>, critically revealed with chest Computed Tomography. In one patient, a thyroid abscess was additionally detected. Both patients presented with fever, not responding to antibiotic therapy. Microbial cultures and molecular testing aided detection of the pathogen. Both patients responded well to antifungal treatment.</div></div>","PeriodicalId":14824,"journal":{"name":"Journal de mycologie medicale","volume":"35 3","pages":"Article 101570"},"PeriodicalIF":2.2,"publicationDate":"2025-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144581379","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Intraventricular mould infection suggestive of Aspergillosis in a 2-year-old child with successful clinical outcomes","authors":"HCV Tulasi Ram ,&nbsp;Madhivanan Karthigeyan ,&nbsp;Aravind Sekar ,&nbsp;Harsimran Kaur ,&nbsp;Pravin Salunke","doi":"10.1016/j.mycmed.2025.101569","DOIUrl":"10.1016/j.mycmed.2025.101569","url":null,"abstract":"<div><div>Pediatric isolated central nervous system (CNS) mould infections are uncommon but potentially fatal if not promptly diagnosed and treated. Such invasive lesions usually present as abscesses in parenchymal locations. Although the newer azole antifungals have shown improved outcomes, treatment data are limited in the pediatric age group, especially in young children. We report a case of a very young child with an unusual location of mould infection, in the temporal horn of the lateral ventricle, managed successfully. The 2-year-old-male child with prior COVID-19 infection and no other apparent immune dysfunction presented with features of raised intracranial pressure. CT/MRI imaging demonstrated a left temporal horn cystic lesion. Following an initial non-diagnostic aspiration of the cyst contents, the child underwent excision of the lesion. The potassium hydroxide stain of the content revealed hyaline septate hyphae, but the fungal culture was sterile. Histopathology of the specimen was highly suggestive of aspergillosis. The child was adequately treated with voriconazole, and had excellent clinical outcome at 22-month follow up. Rarely, CNS mould infection can manifest as an intraventricular space occupying lesion in children. Such a differential must be borne in mind. In our case, the infection was possibly a COVID-19 sequelae. The case also highlights the potential for successful clinical outcomes with an early and aggressive voriconazole treatment in pediatric intracranial mould infections, most likely aspergillosis.</div></div>","PeriodicalId":14824,"journal":{"name":"Journal de mycologie medicale","volume":"35 3","pages":"Article 101569"},"PeriodicalIF":2.2,"publicationDate":"2025-06-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144614606","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Invasive pulmonary aspergillosis in patients with lung cancer: Risk Factors for in-hospital mortality and Predictors of Clinical Outcomes","authors":"Linling Zhang ,&nbsp;Tingting Wu ,&nbsp;Hongyuan Jia","doi":"10.1016/j.mycmed.2025.101560","DOIUrl":"10.1016/j.mycmed.2025.101560","url":null,"abstract":"<div><h3>Background</h3><div>Invasive pulmonary aspergillosis (IPA) is a common complication in patients with hematological malignancies, and has also been reported in some solid tumors, but IPA in lung cancer patients has not been well described in recent years. This study aims to identify the risk factors for in-hospital mortality, and factors influencing antifungal efficacy in lung cancer patients with IPA.</div></div><div><h3>Methods</h3><div>We retrospectively collected data from all inpatients with positive <em>aspergillus</em> cultures or positive polymerase chain reaction(PCR) for <em>aspergillus</em> DeoxyriboNucleic Acid (DNA) in respiratory samples in the Third People's Hospital of Chengdu from January 2016 to December 2023. A total of 101 lung cancer patients with IPA were identified. Patients were divided into survival (<em>n</em> = 77) and non-survival (<em>n</em> = 24) groups. We analyzed their clinical characteristics, laboratory examination, risk factors for in-hospital mortality, and responses to antifungal treatment.</div></div><div><h3>Results</h3><div>Among 101 lung cancer patients diagnosed with IPA, The most common isolated species was <em>Aspergillus section fumigati</em> (61.39 %). <em>Aspergillus</em> culture were positive in 65 cases (64.36 %), and positive PCR were 41 cases (40.59 %). 86 patients (85.15 %) received treatment containing voriconazole or isavuconazole. The in-hospital mortality rate was 23.76 % (<em>n</em> = 24). Independent risk factors for in-hospital mortality included low albumin level (odds ratio [OR] 0.80, 95 % confidence interval[CI], -0.279–1.881, <em>P</em> = 0.0025), respiratory failure (OR 12.7, 95 % CI, 10.2–15.2,<em>P</em> = 0.0055), and febrile neutropenia (FN) (OR 7.33,95 % CI,5.21–9.45,<em>P</em> = 0.0079). In multivariate analysis of antifungal treatment response, respiratory failure was associated with lower odds of a successful response (OR 13.3, 95 %CI, 9.64–16.92, <em>P</em> = 0.0447), whereas treatment containing voriconazole or isavuconazole was associated with higher odds (OR 7.51, 95 % CI, 5.22–9.79, <em>P</em> = 0.0147).</div></div><div><h3>Conclusion</h3><div>Risk factors for in-hospital mortality in lung cancer patients with IPA included hypoalbuminia, FN, and respiratory failure. In antifungal treatment response, respiratory failure was associated with a lower adds of successful response, whereas treatment containing voriconazole or isavuconazole was associated with a higher odds.</div></div>","PeriodicalId":14824,"journal":{"name":"Journal de mycologie medicale","volume":"35 3","pages":"Article 101560"},"PeriodicalIF":2.2,"publicationDate":"2025-06-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144510691","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Fungal infection does not impair flow cytometry signals induced by nCD64 and mCD169 biomarkers during co-infection with bacteria and viruses","authors":"Sandrine Henri,&nbsp;Adélaïde Chesnay,&nbsp;Inès Ait Belkacem,&nbsp;Loïc Gonzalez,&nbsp;Emilie Barsac,&nbsp;Fabrice Malergue,&nbsp;Guillaume Desoubeaux","doi":"10.1016/j.mycmed.2025.101562","DOIUrl":"10.1016/j.mycmed.2025.101562","url":null,"abstract":"","PeriodicalId":14824,"journal":{"name":"Journal de mycologie medicale","volume":"35 3","pages":"Article 101562"},"PeriodicalIF":2.2,"publicationDate":"2025-06-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144536041","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Fatal pulmonary mycoses by Emergomyces pasteurianus in a renal transplant recipient from India","authors":"Harsimran Kaur ,&nbsp;Stephen Raj ,&nbsp;Kapil Gothwal ,&nbsp;Deepesh Kenwar ,&nbsp;Valliappan Muthu ,&nbsp;Haseen Ahmad ,&nbsp;Parikshaa Gupta ,&nbsp;Sourav Agnihotri ,&nbsp;Ashish Sharma ,&nbsp;Shivaprakash M Rudramurthy","doi":"10.1016/j.mycmed.2025.101561","DOIUrl":"10.1016/j.mycmed.2025.101561","url":null,"abstract":"<div><div>We describe a rare case of pulmonary infection by an emerging dimorphic fungus, <em>Emergomyces pasteurianus</em> in a 73-year-old renal transplant recipient from Northern India. The patient presented with fever and shortness of breath for ten days. The bronchoalveolar lavage revealed yeast cells and grew <em>E. pasteurianus</em> confirmed by sequencing internal transcribed spacer (ITS) region and large subunit of rDNA. He succumbed to the illness despite antifungal therapy comprising of liposomal amphotericin B followed by itraconazole. The case emphasizes the emergence of <em>E. pasteurianus</em> in renal transplant recipients.</div></div>","PeriodicalId":14824,"journal":{"name":"Journal de mycologie medicale","volume":"35 3","pages":"Article 101561"},"PeriodicalIF":2.2,"publicationDate":"2025-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144517152","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Phaeohyphomycosis caused by Exophiala oligosperma in liver transplant recipient: case report and literature review","authors":"Regielly Caroline Raimundo Cognialli ,&nbsp;Bram Spruijtenburg ,&nbsp;Leonardo Filipetto Ferrari ,&nbsp;Denise Semchechen Hnatiuk ,&nbsp;Alcindo Pissaia Junior ,&nbsp;Nubia Leilane Barth Schierling ,&nbsp;Germana Davila dos Santos ,&nbsp;Vânia Aparecida Vicente ,&nbsp;Eelco F.J. Meijer ,&nbsp;Flávio Queiroz-Telles","doi":"10.1016/j.mycmed.2025.101558","DOIUrl":"10.1016/j.mycmed.2025.101558","url":null,"abstract":"<div><div>Phaeohyphomycosis (PHM) is a fungal infection caused by a group of dematiaceous (darkly pigmented) fungi. In this study, we describe a successfully treated case of PHM caused by <em>Exophiala oligosperma</em> in a 68-year-old liver transplant recipient who presented with painful erythematous subcutaneous nodules on his lower left limb. Treatment involved a combination of antifungal drugs and surgical excision. We performed review of 13 cases of PHM in liver transplant recipients reported from 2000 to 2024. Eight patients presented with skin and subcutaneous tissue involvement and limbs were the most frequently affected areas. The median time after liver transplant to the diagnosis of PHM was 6 months. Laboratory diagnosis mainly relied on histopathology. Eleven patients received systemic antifungal therapy and seven underwent surgical excision. Full recovery was observed in eleven cases. Altogether, PHM in solid organ transplant recipients is a rare infection and early diagnosis is critical for a favorable outcome.</div></div>","PeriodicalId":14824,"journal":{"name":"Journal de mycologie medicale","volume":"35 3","pages":"Article 101558"},"PeriodicalIF":2.2,"publicationDate":"2025-06-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144297480","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Coccidioidomycosis Lymphadenitis in a patient with Lupus nephritis: A case report","authors":"Gustavo Abraham Canales-Azcona ,&nbsp;Abraham Castellanos-Maldonado ,&nbsp;Héctor Raúl Ibarra-Sifuentes ,&nbsp;Yadhira María González-Amador","doi":"10.1016/j.mycmed.2025.101559","DOIUrl":"10.1016/j.mycmed.2025.101559","url":null,"abstract":"<div><div>Coccidioidomycosis is a fungal infection endemic to arid regions. Although it usually presents as a pulmonary infection, extrapulmonary dissemination is rare, and cervical lymphadenitis is even more unusual with fewer than five cases reported in the literature. Diagnosis of this disease remains a clinical challenge due to its rarity and similarity to other clinical entities. A 34-year-old woman with lupus nephritis on immunosuppressive therapy presented with a painful cervical mass associated with unquantified fever of six weeks of evolution. The patient is a resident of Coahuila, Mexico, in a region adjacent to the Texas–Mexico border. Diagnostic imaging and excisional biopsy with histopathology and culture confirmed cervical lymphadenitis due to Coccidioides. Treatment with oral fluconazole (Diflucan) was started, achieving complete clinical resolution after 12 months. This case highlights the importance of considering different fungal infections in immunocompromised patients presenting with lymphadenopathy. Early diagnosis by biopsy and culture, as well as specific antifungal treatment are essential to obtain favorable results.</div></div>","PeriodicalId":14824,"journal":{"name":"Journal de mycologie medicale","volume":"35 3","pages":"Article 101559"},"PeriodicalIF":2.2,"publicationDate":"2025-06-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144517151","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrigendum to “Clinical profile, antifungal susceptibility, and molecular characterization of Candida auris isolated from patients in a South Indian surgical ICU.” [J Mycol Med (2021) 101176]","authors":"S. Umamaheshwari ,&nbsp;S.M. Neelambike ,&nbsp;S.A. Shankarnarayan ,&nbsp;K.S. Kumarswamy ,&nbsp;S. Gopal ,&nbsp;H. Prakash ,&nbsp;S.M. Rudramurthy","doi":"10.1016/j.mycmed.2025.101552","DOIUrl":"10.1016/j.mycmed.2025.101552","url":null,"abstract":"","PeriodicalId":14824,"journal":{"name":"Journal de mycologie medicale","volume":"35 2","pages":"Article 101552"},"PeriodicalIF":2.2,"publicationDate":"2025-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144069323","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"MP1P antigen detection in urine samples could improve the rapid screening and diagnosis of talaromycosis marneffei","authors":"Yeyang Zhang ,&nbsp;Pengle Guo ,&nbsp;Yaozu He ,&nbsp;Qinzhi Zhang ,&nbsp;Longping Yang ,&nbsp;Yingchun Ke ,&nbsp;Yu Meng ,&nbsp;Feilong Xu ,&nbsp;Xiaopin Tang ,&nbsp;Linghua Li","doi":"10.1016/j.mycmed.2025.101553","DOIUrl":"10.1016/j.mycmed.2025.101553","url":null,"abstract":"<div><h3>Background</h3><div>We evaluated <em>Talaromyces marneffei</em> mannoprotein (Mp1p) antigen in urine to create a practical, rapid diagnostic tool for early treatment and reduced mortality.</div></div><div><h3>Methodology/Principal Findings</h3><div>This prospective cross-sectional study assessed the sensitivity and specificity of Mp1p detection in urine samples from 215 AIDS patients at Guangzhou Eighth People's Hospital, enrolled between March 2022 and January 2023, using ELISA and fluorescence immunochromatography (FIC). In both the Talaromycosis and non-talaromycosis groups, most patients were male, comprising 82.5 % and 88.6 %, respectively. The median age was 42 years for the talaromycosis group and 48 years for the non-talaromycosis group. All patients were HIV-infected, with median CD4+ <em>T</em> cell counts of 47 cells/μL for talaromycosis and 187 cells/μL for non-talaromycosis. Among detection methods, ELISA showed the highest sensitivity (77.5 %, 95 % CI: 61.5–89.2 %) and specificity (97.1 %, 95 % CI: 93.5–99.1 %) for the Mp1p antigen in urine. The Positive Predictive Value (PPV), Negative Predictive Value (NPV), and kappa coefficient were 79.5 % (31/39), 94.9 % (167/176), and 0.739, respectively. The Area Under the Curve (AUC) accuracy for distinguishing patients with talaromycosis was 85.8 % (95 % CI, 76.9–94.9 %). The sensitivity, specificity, PPV, NPV, and kappa value of the Mp1p antigen (Ag) in urine following FIC were 67.5 % (95 % CI: 50.9–81.4 %), 94.9 % (95 % CI: 90.5–97.6 %), 75 % (27/36), 92.7 % (166/179), and 0.649, respectively. Combining urine Mp1p Ag ELISA with serum Mp1p Ag FIC achieved the highest specificity (96 %), PPV (82.1 %), and kappa value (0.767). In contrast, the urine Mp1p Ag ELISA and serum GM Ag pairing showed the highest sensitivity (92.5 %) and NPV (98.1 %).</div></div><div><h3>Conclusions</h3><div>Identification of the Mp1p antigen (Ag) in urine has been shown to be a reliable method for differentiating coinfections in AIDS patients, serving as a supplementary tool for early detection in clinical settings.</div></div>","PeriodicalId":14824,"journal":{"name":"Journal de mycologie medicale","volume":"35 2","pages":"Article 101553"},"PeriodicalIF":2.2,"publicationDate":"2025-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143927434","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ketoconazole-loaded microspone film coating agent for superficial fungal infection: design, preparation and characterization","authors":"Zhaowei Jin ,&nbsp;Danqing Wu ,&nbsp;Yangnan Chen ,&nbsp;Yanqiu Long ,&nbsp;Yan Liu ,&nbsp;Zhiyun Zheng ,&nbsp;Shuangying Gui ,&nbsp;Yuzhe Huang ,&nbsp;Ning He","doi":"10.1016/j.mycmed.2025.101551","DOIUrl":"10.1016/j.mycmed.2025.101551","url":null,"abstract":"<div><div>Ketoconazole (KCZ), an imidazole antifungal drug, is constrained by its low solubility and poor stability, restricting its effective absorption and bioavailability. This study introduces a KCZ-loaded microsponge based film coating agent (KCZ-MSF), designed to enhance the transdermal absorption and bioavailability of KCZ. The KCZ-MS was prepared by emulsion solvent evaporation method and the composition of the prescription was optimized by Box-Behnken design (BBD). Moreover, characterization of the optimized KCZ-MS was conducted using scanning electron microscopy (SEM), Fourier-transform infrared spectroscopy (FTIR), and differential scanning calorimetry (DSC). The film coating agent's preparation was further optimized through orthogonal experiments, converting the optimized KCZ-MS into a film coating agent suitable for topical skin application. The KCZ-MS showed a spherical porous structure with a mean particle size of 22.42 ± 8.45 μm, a drug loading efficiency of 20.74 %, entrapment efficiency of 92.12 %, and good compatibility between the drug and excipients. The optimized KCZ-MSF displayed good physical properties. <em>In vitro</em> transdermal experiments revealed that the skin retention of KCZ-MSF surpassed that of commercially available KCZ cream at 6, 12, and 24 h. The pharmacokinetic experiment results indicate that the area under the curve (<em>AUC</em>_0–24) of KCZ-MSF 420.71 ± 21.77 μg/(g·h) is 2.05 times that of KCZ film coating agent (KCZ-F) and 1.29 times that of commercially available ketoconazole cream. Therefore, KCZ-MSF presents a more promising platform for the treatment of superficial skin fungal infections.</div></div>","PeriodicalId":14824,"journal":{"name":"Journal de mycologie medicale","volume":"35 2","pages":"Article 101551"},"PeriodicalIF":2.2,"publicationDate":"2025-04-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143874773","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}