Journal de mycologie medicale最新文献

{"title":"Letter to the editor - Opinion on \"Epidemiological and Microbiological aspects of Candidozyma auris (Candida auris) in Latin America: A literature review\" by Lanna et al.","authors":"Jeannete Zurita , Ruben Pardo , Gabriela Sevillano , Paulo Freire , Camilo Zurita-Salinas","doi":"10.1016/j.mycmed.2026.101611","DOIUrl":"10.1016/j.mycmed.2026.101611","url":null,"abstract":"","PeriodicalId":14824,"journal":{"name":"Journal de mycologie medicale","volume":"36 2","pages":"Article 101611"},"PeriodicalIF":1.8,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146135653","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrigendum to “Cutaneous and subcutaneous nodular scedosporiosis in a cat” [J Mycol Med (2026) 101609]","authors":"Rita Bitar , Philippe Blumstein , Nicolas Soetart , Pierre Cordier , Maria Dolores Sanchez , Bienvenue Razafimandimby , Faraj Fajloun , Jean-Philippe Bouchara , Jacques Guillot , Emmanuel Bensignor","doi":"10.1016/j.mycmed.2026.101612","DOIUrl":"10.1016/j.mycmed.2026.101612","url":null,"abstract":"","PeriodicalId":14824,"journal":{"name":"Journal de mycologie medicale","volume":"36 2","pages":"Article 101612"},"PeriodicalIF":1.8,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146172814","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Emergent insights on the spread of antifungal-resistant Trichophyton indotineae dermatophyte: Clonal expansion, adaptability dynamics and human–animal host adaptation","authors":"Saleem Ahmad","doi":"10.1016/j.mycmed.2026.101608","DOIUrl":"10.1016/j.mycmed.2026.101608","url":null,"abstract":"<div><div><em>Trichophyton indotineae</em> is an emergent, clonally expanding, multidrug-resistant dermatophyte that emerged from the Indian subcontinent and has disseminated internationally, causing extensive, treatment-refractory tinea. Its phenotypic resemblance to <em>Trichophyton mentagrophytes</em> makes classical identification unreliable, so molecular and proteomic tools such as Internal Transcribed Spacer (ITS) with High Mobility Group (HMG) discrimination, updated MALDI-TOF and Squalene Epoxidase gene (SQLE) sequencing are essential. Resistance is driven by SQLE point mutations (notably Leu393Phe, Phe397Leu and Ala448Thr) that confer high terbinafine Minimum Inhibitory Concentrations (MICs) and have been detected in both human and animal isolates, indicating transmissible, stable resistant clones. The global expansion of <em>Trichophyton indotineae</em> is driven by clonal transmission of terbinafine-resistant strains harboring stable SQLE mutations, compounded by diagnostic ambiguity within the <em>T. mentagrophytes</em> complex and sustained antifungal selection pressure. Its demonstrated ability to persist in the environment and infect both human and animal hosts highlights the pathogen’s adaptive capacity and underscores the need for accurate molecular identification and resistance-guided clinical management.</div></div>","PeriodicalId":14824,"journal":{"name":"Journal de mycologie medicale","volume":"36 2","pages":"Article 101608"},"PeriodicalIF":1.8,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146157251","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pronostic factors for survival in candidemia among onco-hematology patients: a single-center retrospective study during 10 years","authors":"Florian Cardona ,&nbsp;Ferdinand Villetard ,&nbsp;Christophe Zemmour ,&nbsp;Evelyne D'Incan Corda ,&nbsp;Valerio Maisano ,&nbsp;Mariela Catalina Montes de oca ,&nbsp;Robin Noël ,&nbsp;Sabine Fürst ,&nbsp;Faezeh Legrand ,&nbsp;Djamel Mokart ,&nbsp;Antoine Sannini ,&nbsp;Sabine Camiade ,&nbsp;Norbert Vey ,&nbsp;Pierre Berger ,&nbsp;Marie-Anne Hospital","doi":"10.1016/j.mycmed.2026.101605","DOIUrl":"10.1016/j.mycmed.2026.101605","url":null,"abstract":"<div><div>Candidemias are increasing due to an aging and immunocompromised population. The objective of our study is to analyze survival, prognostic factors, and describe the characteristics of candidemias among onco-hematological patient. We conducted a retrospective monocentric study identifying candidemia with at least one positive yeast blood culture among patients with hematological malignancy from January, 1,2010 to December, 31, 2021. We included 135 patients. Mostly lymphoma (47%) and acute leukemia (39%) were the two major disease groups. An active disease was found in 93 patients (69%). <em>Candida albicans</em> (50%) was the most commonly isolated species. Mortality at 30 days after the candidemia was 44% (60/135), reaching 63% (43/68) among patients admitted to the intensive care unit. In the multivariate analysis, severe sepsis (adjusted OR 3.13; 95 % CI 1.09–9.42) and active disease (adjusted OR 4.00; 95% CI 1.41–11.33) were significantly associated with 30-day mortality while acute renal failure (adjusted OR 2.93 95% CI 0.98–8.73) was close to significance. We observed 24 breakthrough infections, with <em>Pichia kudriavzevii</em> being the predominant species among them. The non susceptibility rates to fluconazole and caspofungin were 15.5% (21/135) and 12% (16/135), respectively in the overall population, while reaching 54% (14/24) and 36% (8/24) in the breakthrough infection subgroup. Candidemias in onco-hematology patients are associated with significant mortality. Severe sepsis, active disease, and acute renal failure are adverse prognostic factors at 30 days. Evolving epidemiology of candidemia necessitate prospective monitoring of candidemia epidemiology to adjust prophylaxis. In case of breakthrough infection, we recommend liposomal amphotericin B or voriconazole</div></div>","PeriodicalId":14824,"journal":{"name":"Journal de mycologie medicale","volume":"36 1","pages":"Article 101605"},"PeriodicalIF":1.8,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146034608","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Acknowledging our reviewers","authors":"Alix Coste,&nbsp;Christophe Hennequin,&nbsp;Christine Imbert","doi":"10.1016/j.mycmed.2026.101602","DOIUrl":"10.1016/j.mycmed.2026.101602","url":null,"abstract":"","PeriodicalId":14824,"journal":{"name":"Journal de mycologie medicale","volume":"36 1","pages":"Article 101602"},"PeriodicalIF":1.8,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146188236","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nitroxoline and its combination with antifungals: An alternative for the treatment of fungal biofilm","authors":"Jade André de Souza ,&nbsp;Roger Ferreira Gomes ,&nbsp;Paula Reginatto ,&nbsp;Gabriella da Rosa Monte Machado ,&nbsp;Alexandre Meneghello Fuentefria","doi":"10.1016/j.mycmed.2025.101595","DOIUrl":"10.1016/j.mycmed.2025.101595","url":null,"abstract":"<div><div>Fungal infections represent a significant public health challenge due to their high mortality rates, which can be exacerbated by the ability of fungi, especially <em>Candida</em> species, to form biofilms on medical devices. These opportunistic pathogens are causing candidemia in debilitated patients, contributing to increased hospitalization costs and prolonged recovery times. The existing antifungal therapy has some limitations, including high costs, significant toxicity and the emergence of fungal resistance. In this context, drug repositioning and combined therapy may be an alternative. The 8-hydroxiquinoline's derivatives, like nitroxoline (NTX), have shown biological activities, such as antibacterial and antifungal. This study evaluated the antibiofilm potential of NTX, both in its isolated form and in combination, as a new alternative against yeasts and biofilms of clinical interest. The combinations were tested using the checkerboard technique and the drugs were tested against <em>Candida</em> spp. and <em>Trichosporon</em> spp. biofilms at MIC, MICx2, MICx10 and MICx20. The triple combination of NTX, amphotericin B (AMB) and caspofungin (CSP) showed greater effectiveness, with synergic action, against most of the strains. NTX and its combination with AMB and CSP showed excellent action against <em>Candida</em> spp. and <em>Trichosporon</em> spp, being the most effective in reducing the metabolic activities of the biofilm cells. Hence, NTX and its combination showed a promising antifungal and antibiofilm potential, and its repositioning could represent an immediate and safe alternative in the routine of preventing and treating infections in patients using medical devices.</div></div>","PeriodicalId":14824,"journal":{"name":"Journal de mycologie medicale","volume":"36 1","pages":"Article 101595"},"PeriodicalIF":1.8,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145584335","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Invasive Trichosporon austroamericanum infection following heart transplantation: a case report and literature review of Trichosporon inkin sensu lato infections after thoracic surgery","authors":"Camille Cordier ,&nbsp;Marie Desnos-Ollivier ,&nbsp;Chloë Lemaire ,&nbsp;Céline Goéminne ,&nbsp;Jordan Leroy ,&nbsp;Marjorie Cornu ,&nbsp;Pauline Coulon ,&nbsp;Séverine Loridant ,&nbsp;Ady Assaf ,&nbsp;Fanny Vuotto","doi":"10.1016/j.mycmed.2026.101600","DOIUrl":"10.1016/j.mycmed.2026.101600","url":null,"abstract":"<div><div><em>Trichosporon</em> spp. are ubiquitous basidiomycetous yeast-like fungi, widely distributed in the environment and commonly found in the skin and gastrointestinal microbiota. <em>Trichosporon asahii</em> is the most frequently implicated species in invasive trichosporonosis, usually followed by <em>Trichosporon inkin</em>. In recent years, the incidence of invasive fungal diseases (IFD) caused by rare yeasts of <em>Trichosporon</em> species has increased, predominantly affecting immunocompromised patients.</div><div>Since the late 1990s, several cases of IFD due to <em>Trichosporon inkin sensu lato</em> were reported in European hospitals (France, Spain and UK) in patients with history of thoracic surgery. Recently, <em>Trichosporon austroamericanum</em> has been identified as a new species phylogenetically related to <em>T. inkin</em>.</div><div>Here, we describe a fatal case of disseminated <em>T. austroamericanum</em> infection following heart transplantation, which was initially identified as <em>T. inkin</em>. Given the recent description of <em>T. austroamericanum</em> as a species closely related to <em>T. inkin</em>, we conducted a comprehensive review of all reported <em>T. inkin sensu lato</em> infections occurring after thoracic surgery.</div></div>","PeriodicalId":14824,"journal":{"name":"Journal de mycologie medicale","volume":"36 1","pages":"Article 101600"},"PeriodicalIF":1.8,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145976757","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Antimicrobial susceptibility testing of mixed biofilms formed by Candida spp. and Staphylococcus aureus co-isolated from the sputum of cystic fibrosis patients in Northwest Algeria","authors":"Karima Gourari-Bouzouina ,&nbsp;Zahia Boucherit-Otmani ,&nbsp;Abdelfettah Seghir ,&nbsp;Zahira Zakia Baba Ahmed-Kazi Tani ,&nbsp;Imene Bendoukha ,&nbsp;Abdeselem Benahmed ,&nbsp;Mohammed Aissaoui ,&nbsp;Kebir Boucherit","doi":"10.1016/j.mycmed.2025.101596","DOIUrl":"10.1016/j.mycmed.2025.101596","url":null,"abstract":"<div><div>Cystic fibrosis (CF) is associated with recurring lung infections, which are commonly caused by <em>Staphylococcus aureus</em> and <em>Candida</em> species. These pathogens often form polymicrobial biofilms that are resistant to conventional treatments. Studying their interactions and testing effective therapies is essential for better CF infection control. The current study aimed to examine the antifungal and antibacterial activity of each alone against <em>Candida</em> species and <em>S. aureus</em> co-isolated in both states, planktonic and biofilm (single and polymicrobial biofilm), then in combination for the mixed biofilm of <em>C. tropicalis-S. aureus</em>24. Both <em>Candida</em> spp. and <em>S. aureus</em> isolates were sensitive to the tested antifungals and antibiotics in planktonic mode. However, in biofilm mode, SMICs were up to 32 times higher than SMICs for both species. Thus, all the strains tested are capable of forming biofilms. Treatment of multi-species biofilms (<em>C. tropicalis1/S. aureus24</em>) with combinations of antifungals and antibiotics (AmB/VAN, AmB/AK, AmB/GEN, AmB/CIP) and (Vrc/VAN, Vrc/AK, Vrc/GEN, Vrc/CIP) showed a significant reduction in SMICs compared with those obtained with the two antimicrobials separately. Calculation of the FICIs highlighted two types of interactions, synergistic and indifferent, between the antifungals and the antibiotics tested. The study shows that antifungal-antibiotic combinations can effectively reduce biofilm resistance in CF infections. These synergistic effects may improve treatment outcomes while lowering drug doses and resistance risk.</div></div>","PeriodicalId":14824,"journal":{"name":"Journal de mycologie medicale","volume":"36 1","pages":"Article 101596"},"PeriodicalIF":1.8,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145622684","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The innate immune response to A. fumigatus in alveolar macrophages: Roles of LC3-associated phagocytosis, apoptosis and inflammation","authors":"Yuqing Sun ,&nbsp;Xiao Cui ,&nbsp;Yulin Zhang","doi":"10.1016/j.mycmed.2025.101598","DOIUrl":"10.1016/j.mycmed.2025.101598","url":null,"abstract":"<div><div><em>Aspergillus fumigatus</em> (<em>A. fumigatus</em>) has a life-threatening effect in immunocompromised populations, underscore the vital role played by the interplay between the host immune response and this fungal pathogen. Alveolar macrophage (AM) situated within the alveolar spaces serve as the primal immune cells to engage with inhaled Aspergillus conidia. These AMs deploy various strategies to resist A. fumigatus assaults. Their capacity to eliminate <em>A. fumigatus</em> is contingent upon LC3-associated phagocytosis (LAP), an immunological safeguard against microbial intrusions. Furthermore, the propensity for apoptosis fosters frequent inter-macrophage transfer of <em>A. fumigatus</em>, thereby facilitating control over conidia germination. The activation of inflammasomes and the subsequent release of cytokines and chemokines also constitutes a crucial defensive mechanism employed by AM against <em>A. fumigatus</em> invasions. This review delves into the intricate immune reactions and protective manners mounted by macrophages during <em>A. fumigatus</em> infection. Unraveling the interactions between the host immune system and <em>A. fumigatus</em> could pave the way for innovative therapeutic interventions.</div></div>","PeriodicalId":14824,"journal":{"name":"Journal de mycologie medicale","volume":"36 1","pages":"Article 101598"},"PeriodicalIF":1.8,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145742303","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cutaneous and subcutaneous nodular scedosporiosis in a cat","authors":"Rita Bitar ,&nbsp;Philippe Blumstein ,&nbsp;Nicolas Soetart ,&nbsp;Pierre Cordier ,&nbsp;Maria-dolores Sanchez ,&nbsp;Bienvenue Razafimandimby ,&nbsp;Faraj Fajloun ,&nbsp;Jean-Philippe Bouchara ,&nbsp;Jacques Guillot ,&nbsp;Emmanuel Bensignor","doi":"10.1016/j.mycmed.2026.101609","DOIUrl":"10.1016/j.mycmed.2026.101609","url":null,"abstract":"<div><div>This article reports the clinical, diagnostic, and therapeutic aspects of a rare case of cutaneous and subcutaneous scedosporiosis in a 16-year-old domestic cat. The animal presented with a painful, ulcerated nodule at the base of the tail. Histopathology and fungal culture confirmed a pyogranulomatous dermatitis with hyaline hyphae, and molecular analysis identified <em>Scedosporium sphaerospermum</em>, a soil-dwelling fungus newly described. Despite targeted antifungal treatment with itraconazole and topical ciclopirox olamine, the cat developed systemic complications and died. This case emphasizes the challenges associated with diagnosing and managing opportunistic fungal infections in companion animals. It is, to the authors’ knowledge, the first case of infection caused by <em>S. sphaerospermum</em>.</div></div>","PeriodicalId":14824,"journal":{"name":"Journal de mycologie medicale","volume":"36 1","pages":"Article 101609"},"PeriodicalIF":1.8,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146100290","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}