ISRN Hematology最新文献_第5页

Need for nucleic Acid testing in countries with high prevalence of transfusion-transmitted infections. 在输血传播感染高发国家进行核酸检测的必要性。

ISRN Hematology Pub Date : 2012-01-01 Epub Date: 2012-09-12 DOI: 10.5402/2012/718671

Rohit Jain, Pankaj Aggarwal, Gajendra Nath Gupta

{"title":"Need for nucleic Acid testing in countries with high prevalence of transfusion-transmitted infections.","authors":"Rohit Jain, Pankaj Aggarwal, Gajendra Nath Gupta","doi":"10.5402/2012/718671","DOIUrl":"10.5402/2012/718671","url":null,"abstract":"Introduction. In India, family/replacement donors still provide more than 45% of the collected blood. With increasing voluntary blood donation and the still-prevalent infectious diseases in donors, we need to augment transfusion-transmitted infections (TTIs) testing before use. Our study was aimed to know the seroprevalence of TTIs among the donors of Rajasthan and the need for newer technologies like nucleic acid testing (NAT). Materials and Methods. Enhanced chemiluminescence immunoassay (ECi) was used for detection of HBsAg, anti-HIV, and anti-HCV in donor serum. 50% of the blood units which were negative on ECi were randomly selected and subjected to NAT testing for HBV, HCV, and HIV. Results. The total seroprevalence of TTIs is 2.62%. Of the randomly selected donor units negative by ECi, 8 turned out to be reactive on NAT testing: 4 were voluntary and 4 were family/replacement donors. Combined NAT yield (NAT reactive/seronegative) for HIV, HCV, and HBV was 0.034% (1 in 2972 donations). All the 8 reactive samples were positive for HBV DNA. Conclusion. In countries with a high prevalence of TTIs like India there are likely to be a significant number of window period donations that can be identified by NAT which may be implemented in blood centers allover India with serological testing to provide safe blood and cost alone should not be a deterrent to the government and implementing agencies.","PeriodicalId":14727,"journal":{"name":"ISRN Hematology","volume":"2012 ","pages":"718671"},"PeriodicalIF":0.0,"publicationDate":"2012-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3447329/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"30930218","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cotransduction with MGMT and Ubiquitous or Erythroid-Specific GFP Lentiviruses Allows Enrichment of Dual-Positive Hematopoietic Progenitor Cells In Vivo. 与MGMT和普遍存在的或红细胞特异性GFP慢病毒的协同转导允许在体内富集双阳性造血祖细胞。

ISRN Hematology Pub Date : 2012-01-01 Epub Date: 2012-07-19 DOI: 10.5402/2012/212586

Justin C Roth, Mourad Ismail, Jane S Reese, Karen T Lingas, Giuliana Ferrari, Stanton L Gerson

{"title":"Cotransduction with MGMT and Ubiquitous or Erythroid-Specific GFP Lentiviruses Allows Enrichment of Dual-Positive Hematopoietic Progenitor Cells In Vivo.","authors":"Justin C Roth, Mourad Ismail, Jane S Reese, Karen T Lingas, Giuliana Ferrari, Stanton L Gerson","doi":"10.5402/2012/212586","DOIUrl":"https://doi.org/10.5402/2012/212586","url":null,"abstract":"The P140K point mutant of MGMT allows robust hematopoietic stem cell (HSC) enrichment in vivo. Thus, dual-gene vectors that couple MGMT and therapeutic gene expression have allowed enrichment of gene-corrected HSCs in animal models. However, expression levels from dual-gene vectors are often reduced for one or both genes. Further, it may be desirable to express selection and therapeutic genes at distinct stages of cell differentiation. In this regard, we evaluated whether hematopoietic cells could be efficiently cotransduced using low MOIs of two separate single-gene lentiviruses, including MGMT for dual-positive cell enrichment. Cotransduction efficiencies were evaluated using a range of MGMT : GFP virus ratios, MOIs, and selection stringencies in vitro. Cotransduction was optimal when equal proportions of each virus were used, but low MGMT : GFP virus ratios resulted in the highest proportion of dual-positive cells after selection. This strategy was then evaluated in murine models for in vivo selection of HSCs cotransduced with a ubiquitous MGMT expression vector and an erythroid-specific GFP vector. Although the MGMT and GFP expression percentages were variable among engrafted recipients, drug selection enriched MGMT-positive leukocyte and GFP-positive erythroid cell populations. These data demonstrate cotransduction as a mean to rapidly enrich and evaluate therapeutic lentivectors in vivo.","PeriodicalId":14727,"journal":{"name":"ISRN Hematology","volume":"2012 ","pages":"212586"},"PeriodicalIF":0.0,"publicationDate":"2012-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.5402/2012/212586","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"30830341","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 6

Inhibition of LPS-Induced Activation of Coagulation by p38 MAPK Inhibitor. p38 MAPK抑制剂对lps诱导凝血活化的抑制作用

ISRN Hematology Pub Date : 2012-01-01 Epub Date: 2012-03-05 DOI: 10.5402/2012/762614

Lutz Koch, Stefan Hofer, Markus A Weigand, David Frommhold, Johannes Poeschl, Peter Ruef

{"title":"Inhibition of LPS-Induced Activation of Coagulation by p38 MAPK Inhibitor.","authors":"Lutz Koch, Stefan Hofer, Markus A Weigand, David Frommhold, Johannes Poeschl, Peter Ruef","doi":"10.5402/2012/762614","DOIUrl":"https://doi.org/10.5402/2012/762614","url":null,"abstract":"During Gram-negative sepsis, lipopolysaccharide (LPS) activates toll-like receptor (TLR) 4 and induces complex responses of immune system and coagulation. However, the underlying LPS signalling mechanism on coagulation activation remains complex. To determine the role of the intracellular signalling factors p38 mitogen-activated protein kinase (MAPK), nuclear factor-kappa B (NF-κB), and c-Jun N-terminal kinase (JNK) in the procoagulant response to LPS, coagulation process of human whole blood exposed to specific inhibitors was measured by thrombelastography. Samples were stimulated with LPS (100 μg/mL) after preincubation with BAY117082 (specific NF-κB inhibitor), SP600125 (specific JNK inhibitor), SB203580 (specific p38 MAPK inhibitor), or vehicle. SB203580 strongly inhibited LPS-induced coagulation activation, whereas BAY117082 and SP600125 showed no significant effect. Activation of p38 MAPK, NF-κB, and JNK and respective inhibitory effects were confirmed by Multi-Target Sandwich ELISA. In conclusion, activation of p38 MAPK is crucial for early LPS-induced activation of coagulation.","PeriodicalId":14727,"journal":{"name":"ISRN Hematology","volume":"2012 ","pages":"762614"},"PeriodicalIF":0.0,"publicationDate":"2012-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.5402/2012/762614","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"30541588","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 7

Innate Immunity in Lobsters: Partial Purification and Characterization of a Panulirus cygnus Anti-A Lectin. 龙虾先天免疫:cygnus抗a凝集素的部分纯化和特性。

ISRN Hematology Pub Date : 2012-01-01 Epub Date: 2012-03-05 DOI: 10.5402/2012/964986

Robert L P Flower

引用次数: 1

Detection of common deletional alpha-thalassemia spectrum by molecular technique in kelantan, northeastern malaysia. 用分子技术检测马来西亚东北部吉兰丹常见缺失型-地中海贫血谱。

ISRN Hematology Pub Date : 2012-01-01 Epub Date: 2012-07-19 DOI: 10.5402/2012/462969

B Rosnah, H Rosline, A Wan Zaidah, M N Noor Haslina, R Marini, M Y Shafini, F A Nurul Ain

{"title":"Detection of common deletional alpha-thalassemia spectrum by molecular technique in kelantan, northeastern malaysia.","authors":"B Rosnah, H Rosline, A Wan Zaidah, M N Noor Haslina, R Marini, M Y Shafini, F A Nurul Ain","doi":"10.5402/2012/462969","DOIUrl":"https://doi.org/10.5402/2012/462969","url":null,"abstract":"Thalassemia is a hereditary blood disorder that results from genetic defects causing deficient synthesis of hemoglobin polypeptide chains. Although thalassemia mostly affects developing countries, there is limited knowledge of its accurate frequency and distribution in these regions. Knowing the prevalence of thalassemia and the frequency of responsible mutations is therefore an important step in the prevention and control program as well as treatment strategies. This study was performed to determine the prevalence and to study the spectrum of gene deletions that are responsible in α-thalassemia in Kelantan, located in northeastern Malaysia. A total 400 first-time blood donors from multiple areas of donation centre were chosen randomly. The presence of three types of α-thalassemia gene deletion in southeast Asian population which were -(SEA)deletion, -α(3.7) rightward deletion, and -α(4.2) leftward deletion was detected by using multiplex PCR method. 37 (9.25%) of blood donors were confirmed to have α-thalassemia deletion types. 34 (8%) were heterozygous for α3.7 deletion, 1 (0.25%) was heterozygous for α4.2 deletion, and 2 (0.5%) were heterozygous for SEA type deletion. Alpha-thalassemia-2 with 3.7 deletion was the most common determinant detected in Kelantan Malay compared to other ethnic groups. It has been noted that alpha-thalassemia-2 with 3.7 deletion is the most common type of α-thalassemia throughout the world.","PeriodicalId":14727,"journal":{"name":"ISRN Hematology","volume":"2012 ","pages":"462969"},"PeriodicalIF":0.0,"publicationDate":"2012-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.5402/2012/462969","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"30830343","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 20

Transfusion practices in the management of sickle cell disease: a survey of Florida hematologists/oncologists. 输血实践在镰状细胞病的管理:佛罗里达州血液学家/肿瘤学家的调查。

ISRN Hematology Pub Date : 2012-01-01 Epub Date: 2012-12-12 DOI: 10.5402/2012/524513

Levette N Dunbar, Larae Coleman Brown, Donna R Rivera, Abraham G Hartzema, Richard Lottenberg

{"title":"Transfusion practices in the management of sickle cell disease: a survey of Florida hematologists/oncologists.","authors":"Levette N Dunbar, Larae Coleman Brown, Donna R Rivera, Abraham G Hartzema, Richard Lottenberg","doi":"10.5402/2012/524513","DOIUrl":"https://doi.org/10.5402/2012/524513","url":null,"abstract":"The purpose of this study was to characterize transfusion practices in the management of sickle cell disease and to identify factors attributing to differences in prescribing practices among Florida hematologists/oncologists. A cross-sectional study was performed in 2005-2006 utilizing a mail survey. The survey instrument addressed practice characteristics, sickle cell patient populations, transfusion settings, indications and techniques, red blood cell phenotype specifications/modifications, use of practice guidelines, and educational resource utilization. One hundred fifty two physicians (75% adult-oriented, 25% pediatric) completed the survey. Non-academic practice settings (78 %) were the primary location. Pediatric practices had a larger percentage of patients with overt strokes, and receiving hydroxyurea therapy than adult-oriented practices. The majority of survey respondents did not request limited phenotypically matched red blood cells on a routine basis. The majority of pediatric practices (60%) had individually defined transfusion practice guidelines in contrast to 8% of adult-oriented practices. There were statistically significant differences for pediatric and adult-oriented practices in managing certain acute and chronic transfusion indications. Analysis of clinical vignette data revealed variation among hematologists/oncologists in the transfusion management of common clinical scenarios. The study underscores the need for the development and dissemination of comprehensive sickle cell transfusion guidelines and protocols.","PeriodicalId":14727,"journal":{"name":"ISRN Hematology","volume":"2012 ","pages":"524513"},"PeriodicalIF":0.0,"publicationDate":"2012-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.5402/2012/524513","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"31158976","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 9

Evaluation of X-Chromosome Inactivation Patterns in Patients with Acute Myeloid Leukemia during Remission. 急性髓系白血病缓解期患者x染色体失活模式的评价。

ISRN Hematology Pub Date : 2012-01-01 Epub Date: 2012-10-23 DOI: 10.5402/2012/971493

Yousef Mortazavi, Saeid Kaviani, Fatemeh Mirzamohammadi, Kamran Alimoghaddam, Ali Akbar Pourfathollah, Oveis Salehi

{"title":"Evaluation of X-Chromosome Inactivation Patterns in Patients with Acute Myeloid Leukemia during Remission.","authors":"Yousef Mortazavi, Saeid Kaviani, Fatemeh Mirzamohammadi, Kamran Alimoghaddam, Ali Akbar Pourfathollah, Oveis Salehi","doi":"10.5402/2012/971493","DOIUrl":"https://doi.org/10.5402/2012/971493","url":null,"abstract":"The aim of this study was to evaluate the patterns of X-chromosome inactivation during the remission in acute myeloid leukemia (AML) at the RNA level. Two hundred normal females and 45 female patients with AML entered the study. The frequency of heterozygosity was 48.5% (119/245) for P55, 40% (93/245) for IDS, and only 28.9% (71/245) for G6PD. Some individuals were heterozygous for more than one gene polymorphism. Overall, one hundred normal individuals proved showed to be heterozygous for at least one of the above polymorphisms. 92/100 (92%) normal females showed a polyclonal pattern. Clonal patterns were observed in 44/45 (98%) AML patients at presentation. Of 27 patients who were followed after remission, 23 (85.2%) patients showed a clonal pattern. Ten patients were available for a longer followup (up to 12 months) and the clonal pattern was observed in seven patients. It can be concluded that clonality at remission is a frequent event in AML and does not necessarily mean relapse of the disease. There is also a possibility of conversion of clonality to polyclonality over time.","PeriodicalId":14727,"journal":{"name":"ISRN Hematology","volume":"2012 ","pages":"971493"},"PeriodicalIF":0.0,"publicationDate":"2012-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.5402/2012/971493","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"31048666","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Implications of weight and body mass index for plasma donation and health. 体重和体重指数对血浆捐献和健康的影响。

ISRN Hematology Pub Date : 2012-01-01 Epub Date: 2012-11-14 DOI: 10.5402/2012/937585

Genna A Jerrard, Jing Liu, Rosemary C Case, Mahnaz Motevalli, Stephen G Bolton, Karen E King, John Beigel, J Brooks Jackson

{"title":"Implications of weight and body mass index for plasma donation and health.","authors":"Genna A Jerrard, Jing Liu, Rosemary C Case, Mahnaz Motevalli, Stephen G Bolton, Karen E King, John Beigel, J Brooks Jackson","doi":"10.5402/2012/937585","DOIUrl":"10.5402/2012/937585","url":null,"abstract":"This study determined the percentage of potential plasma donors who could donate plasma in the 3 allowable plasma volume limit categories as specified by the Food and Drug Administration (FDA), as well as the association of the body mass index (BMI) of these individuals with age, blood pressure, oral temperature, and pulse. Of 315 plasma donors analyzed, 107 (34.0%) weighed between 110 and 149 lbs (50.0-67.7 kg), 89 (28.2%) weighed between 150 and174 lbs (68.2-79.1 kg), and 119 (37.8%) weighed >175 lbs (79.5 kg), theoretically allowing collection of an additional 101.4 liters (16% more plasma) from both heavier categories based on FDA standards for plasma donor quantities. BMI was positively associated with age, mean arterial pressure (MAP), and pulse (Pearson's r = 0.36, 0.24, and 0.18, resp., P values <0.05), but not with oral temperature. Average BMI for females was higher than for males (+1.8, P = 0.01), and BMI for African Americans was higher than for White and Asian participants (+2.2 and +5.1, resp., Ps <0.05). A significant association was also found in the sex by race interaction with BMI (P = 0.0004). Follow-up analyses suggested a significant difference in BMI by sex among African Americans, higher BMI among African American females than Asian and White males, and higher BMI among White females than African American males (Ps <0.05).","PeriodicalId":14727,"journal":{"name":"ISRN Hematology","volume":"2012 ","pages":"937585"},"PeriodicalIF":0.0,"publicationDate":"2012-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3504381/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"31096909","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

K(3)EDTA Vacuum Tubes Validation for Routine Hematological Testing. K(3)EDTA真空管常规血液学检测验证。

ISRN Hematology Pub Date : 2012-01-01 Epub Date: 2012-07-24 DOI: 10.5402/2012/875357

Gabriel Lima-Oliveira, Giuseppe Lippi, Gian Luca Salvagno, Martina Montagnana, Giovanni Poli, Giovanni Pietro Solero, Geraldo Picheth, Gian Cesare Guidi

{"title":"K(3)EDTA Vacuum Tubes Validation for Routine Hematological Testing.","authors":"Gabriel Lima-Oliveira, Giuseppe Lippi, Gian Luca Salvagno, Martina Montagnana, Giovanni Poli, Giovanni Pietro Solero, Geraldo Picheth, Gian Cesare Guidi","doi":"10.5402/2012/875357","DOIUrl":"https://doi.org/10.5402/2012/875357","url":null,"abstract":"Background and Objective. Some in vitro diagnostic devices (e.g, blood collection vacuum tubes and syringes for blood analyses) are not validated before the quality laboratory managers decide to start using or to change the brand. Frequently, the laboratory or hospital managers select the vacuum tubes for blood collection based on cost considerations or on relevance of a brand. The aim of this study was to validate two dry K(3)EDTA vacuum tubes of different brands for routine hematological testing. Methods. Blood specimens from 100 volunteers in two different K(3)EDTA vacuum tubes were collected by a single, expert phlebotomist. The routine hematological testing was done on Advia 2120i hematology system. The significance of the differences between samples was assessed by paired Student's t-test after checking for normality. The level of statistical significance was set at P < 0.05. Results and Conclusions. Different brand's tubes evaluated can represent a clinically relevant source of variations only on mean platelet volume (MPV) and platelet distribution width (PDW). Basically, our validation will permit the laboratory or hospital managers to select the brand's vacuum tubes validated according to him/her technical or economical reasons for routine hematological tests.","PeriodicalId":14727,"journal":{"name":"ISRN Hematology","volume":"2012 ","pages":"875357"},"PeriodicalIF":0.0,"publicationDate":"2012-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.5402/2012/875357","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"30830344","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 21

Intermittent iron folate supplementation: impact on hematinic status and growth of school girls. 间歇性补充叶酸铁:对女学生血液状态和生长的影响。

ISRN Hematology Pub Date : 2012-01-01 Epub Date: 2012-07-26 DOI: 10.5402/2012/482153

Aditi Sen, Shubhada Kanani

{"title":"Intermittent iron folate supplementation: impact on hematinic status and growth of school girls.","authors":"Aditi Sen, Shubhada Kanani","doi":"10.5402/2012/482153","DOIUrl":"https://doi.org/10.5402/2012/482153","url":null,"abstract":"Unlabelled: In view of high iron needs for adolescent growth, this paper studied the impact of daily vs. intermittent (once and twice weekly) iron folic acid (IFA) supplementation on hemoglobin levels and pubertal growth among primary school girls in early adolescence (9-13 years) of Vadodara, India. Methods. Hemoglobin (Hb), height and weight of the girls were assessed using standard methods. In three experimental schools (ES) IFA tablets in a dose of 100 mg Fe + 0.5 mg folic acid was given either daily, once weekly or twice weekly for one year. The fourth school (control: CS) did not receive any intervention. Results. Hb levels significantly improved (P < 0.01) in all ES compared to CS. Body Mass Index (BMI) increment in ES vs CS was significant (P < 0.05) in twice weekly IFA and daily IFA. Within ES groups, mean Hb and BMI increments were comparable between twice weekly IFA and daily IFA. Anemic ES girls showed higher Hb and BMI increments vs. non-anemic girls. Better the Hb response, greater was the benefit on BMI.Conclusion: Twice-weekly IFA supplementation was comparable to daily IFA as regards impact on Hb and growth; at less cost and greater feasibility. Once-weekly dose was inadequate to significantly improve growth.","PeriodicalId":14727,"journal":{"name":"ISRN Hematology","volume":"2012 ","pages":"482153"},"PeriodicalIF":0.0,"publicationDate":"2012-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.5402/2012/482153","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"30856179","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 17